Details of the Target

General Information of Target

Target ID LDTP10071
Target Name Protein mago nashi homolog 2 (MAGOHB)
Gene Name MAGOHB
Gene ID 55110
Synonyms
MAGOH2; Protein mago nashi homolog 2
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAGYLSESDFVMVEEGFSTRDLLKELTLGASQATTDEVAAFFVADLGAIVRKHFCFLKCL
PRVRPFYAVKCNSSPGVLKVLAQLGLGFSCANKAEMELVQHIGIPASKIICANPCKQIAQ
IKYAAKHGIQLLSFDNEMELAKVVKSHPSAKMVLCIATDDSHSLSCLSLKFGVSLKSCRH
LLENAKKHHVEVVGVSFHIGSGCPDPQAYAQSIADARLVFEMGTELGHKMHVLDLGGGFP
GTEGAKVRFEEIASVINSALDLYFPEGCGVDIFAELGRYYVTSAFTVAVSIIAKKEVLLD
QPGREEENGSTSKTIVYHLDEGVYGIFNSVLFDNICPTPILQKKPSTEQPLYSSSLWGPA
VDGCDCVAEGLWLPQLHVGDWLVFDNMGAYTVGMGSPFWGTQACHITYAMSRVAWEALRR
QLMAAEQEDDVEGVCKPLSCGWEITDTLCVGPVFTPASIM
Target Bioclass
Other
Family
Mago nashi family
Subcellular location
Nucleus
Function Required for pre-mRNA splicing as component of the spliceosome. Plays a redundant role with MAGOH in the exon junction complex and in the nonsense-mediated decay (NMD) pathway.
Uniprot ID
Q96A72
Ensemble ID
ENST00000320756.7
HGNC ID
HGNC:25504

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
TH211
 Probe Info  		Y42(5.36); Y53(16.07)  LDD0260  [2]
ONAyne
 Probe Info  		K16(1.19)  LDD0274  [3]
STPyne
 Probe Info  		K16(8.56); K43(9.72); K50(3.81)  LDD0277  [3]
IA-alkyne
 Probe Info  		C133(6.78)  LDD2157  [4]
EA-probe
 Probe Info  		C133(0.81)  LDD2210  [5]
HHS-482
 Probe Info  		Y42(0.84)  LDD0285  [6]
HHS-475
 Probe Info  		Y42(0.96); Y36(1.84)  LDD0264  [7]
HHS-465
 Probe Info  		Y53(4.44)  LDD2237  [8]
DBIA
 Probe Info  		C133(1.12)  LDD0078  [9]
Acrolein
 Probe Info  		N.A.  LDD0217  [10]
Crotonaldehyde
 Probe Info  		H55(0.00); H15(0.00)  LDD0219  [10]
AOyne
 Probe Info  		15.00  LDD0443  [11]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		20.00  LDD0475  [12]
FFF probe3
 Probe Info  		12.73  LDD0464  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C133(1.25)  LDD0531  [9]
 LDCM0215  AC10 HCT 116 C133(1.25)  LDD0532  [9]
 LDCM0216  AC100 HCT 116 C133(0.88)  LDD0533  [9]
 LDCM0217  AC101 HCT 116 C133(0.92)  LDD0534  [9]
 LDCM0218  AC102 HCT 116 C133(0.99)  LDD0535  [9]
 LDCM0219  AC103 HCT 116 C133(1.12)  LDD0536  [9]
 LDCM0220  AC104 HCT 116 C133(1.21)  LDD0537  [9]
 LDCM0221  AC105 HCT 116 C133(1.15)  LDD0538  [9]
 LDCM0222  AC106 HCT 116 C133(1.12)  LDD0539  [9]
 LDCM0223  AC107 HCT 116 C133(1.19)  LDD0540  [9]
 LDCM0224  AC108 HCT 116 C133(0.83)  LDD0541  [9]
 LDCM0225  AC109 HCT 116 C133(0.86)  LDD0542  [9]
 LDCM0226  AC11 HCT 116 C133(1.42)  LDD0543  [9]
 LDCM0227  AC110 HCT 116 C133(0.89)  LDD0544  [9]
 LDCM0228  AC111 HCT 116 C133(0.93)  LDD0545  [9]
 LDCM0229  AC112 HCT 116 C133(1.08)  LDD0546  [9]
 LDCM0230  AC113 HCT 116 C133(1.01)  LDD0547  [9]
 LDCM0231  AC114 HCT 116 C133(1.14)  LDD0548  [9]
 LDCM0232  AC115 HCT 116 C133(1.35)  LDD0549  [9]
 LDCM0233  AC116 HCT 116 C133(1.31)  LDD0550  [9]
 LDCM0234  AC117 HCT 116 C133(1.20)  LDD0551  [9]
 LDCM0235  AC118 HCT 116 C133(1.18)  LDD0552  [9]
 LDCM0236  AC119 HCT 116 C133(1.21)  LDD0553  [9]
 LDCM0237  AC12 HCT 116 C133(1.14)  LDD0554  [9]
 LDCM0238  AC120 HCT 116 C133(1.38)  LDD0555  [9]
 LDCM0239  AC121 HCT 116 C133(1.13)  LDD0556  [9]
 LDCM0240  AC122 HCT 116 C133(1.27)  LDD0557  [9]
 LDCM0241  AC123 HCT 116 C133(1.08)  LDD0558  [9]
 LDCM0242  AC124 HCT 116 C133(1.05)  LDD0559  [9]
 LDCM0243  AC125 HCT 116 C133(1.13)  LDD0560  [9]
 LDCM0244  AC126 HCT 116 C133(1.36)  LDD0561  [9]
 LDCM0245  AC127 HCT 116 C133(1.21)  LDD0562  [9]
 LDCM0246  AC128 HCT 116 C133(1.29)  LDD0563  [9]
 LDCM0247  AC129 HCT 116 C133(0.78)  LDD0564  [9]
 LDCM0249  AC130 HCT 116 C133(1.00)  LDD0566  [9]
 LDCM0250  AC131 HCT 116 C133(0.88)  LDD0567  [9]
 LDCM0251  AC132 HCT 116 C133(1.07)  LDD0568  [9]
 LDCM0252  AC133 HCT 116 C133(0.99)  LDD0569  [9]
 LDCM0253  AC134 HCT 116 C133(1.00)  LDD0570  [9]
 LDCM0254  AC135 HCT 116 C133(1.12)  LDD0571  [9]
 LDCM0255  AC136 HCT 116 C133(1.12)  LDD0572  [9]
 LDCM0256  AC137 HCT 116 C133(1.04)  LDD0573  [9]
 LDCM0257  AC138 HCT 116 C133(1.04)  LDD0574  [9]
 LDCM0258  AC139 HCT 116 C133(0.97)  LDD0575  [9]
 LDCM0259  AC14 HCT 116 C133(1.17)  LDD0576  [9]
 LDCM0260  AC140 HCT 116 C133(1.06)  LDD0577  [9]
 LDCM0261  AC141 HCT 116 C133(0.98)  LDD0578  [9]
 LDCM0262  AC142 HCT 116 C133(0.83)  LDD0579  [9]
 LDCM0263  AC143 HCT 116 C133(1.11)  LDD0580  [9]
 LDCM0264  AC144 HCT 116 C133(1.27)  LDD0581  [9]
 LDCM0265  AC145 HCT 116 C133(1.17)  LDD0582  [9]
 LDCM0266  AC146 HCT 116 C133(1.30)  LDD0583  [9]
 LDCM0267  AC147 HCT 116 C133(1.45)  LDD0584  [9]
 LDCM0268  AC148 HCT 116 C133(1.76)  LDD0585  [9]
 LDCM0269  AC149 HCT 116 C133(1.48)  LDD0586  [9]
 LDCM0270  AC15 HCT 116 C133(1.42)  LDD0587  [9]
 LDCM0271  AC150 HCT 116 C133(1.20)  LDD0588  [9]
 LDCM0272  AC151 HCT 116 C133(1.11)  LDD0589  [9]
 LDCM0273  AC152 HCT 116 C133(1.56)  LDD0590  [9]
 LDCM0274  AC153 HCT 116 C133(1.81)  LDD0591  [9]
 LDCM0621  AC154 HCT 116 C133(1.27)  LDD2158  [9]
 LDCM0622  AC155 HCT 116 C133(1.23)  LDD2159  [9]
 LDCM0623  AC156 HCT 116 C133(1.00)  LDD2160  [9]
 LDCM0624  AC157 HCT 116 C133(0.94)  LDD2161  [9]
 LDCM0276  AC17 HCT 116 C133(1.11)  LDD0593  [9]
 LDCM0277  AC18 HCT 116 C133(1.51)  LDD0594  [9]
 LDCM0278  AC19 HCT 116 C133(1.05)  LDD0595  [9]
 LDCM0279  AC2 HCT 116 C133(1.10)  LDD0596  [9]
 LDCM0280  AC20 HCT 116 C133(1.15)  LDD0597  [9]
 LDCM0281  AC21 HCT 116 C133(1.08)  LDD0598  [9]
 LDCM0282  AC22 HCT 116 C133(1.07)  LDD0599  [9]
 LDCM0283  AC23 HCT 116 C133(0.98)  LDD0600  [9]
 LDCM0284  AC24 HCT 116 C133(1.07)  LDD0601  [9]
 LDCM0285  AC25 HCT 116 C133(1.19)  LDD0602  [9]
 LDCM0286  AC26 HCT 116 C133(1.28)  LDD0603  [9]
 LDCM0287  AC27 HCT 116 C133(1.27)  LDD0604  [9]
 LDCM0288  AC28 HCT 116 C133(1.48)  LDD0605  [9]
 LDCM0289  AC29 HCT 116 C133(1.16)  LDD0606  [9]
 LDCM0290  AC3 HCT 116 C133(1.19)  LDD0607  [9]
 LDCM0291  AC30 HCT 116 C133(1.35)  LDD0608  [9]
 LDCM0292  AC31 HCT 116 C133(1.26)  LDD0609  [9]
 LDCM0293  AC32 HCT 116 C133(1.48)  LDD0610  [9]
 LDCM0294  AC33 HCT 116 C133(1.43)  LDD0611  [9]
 LDCM0295  AC34 HCT 116 C133(1.86)  LDD0612  [9]
 LDCM0296  AC35 HCT 116 C133(0.90)  LDD0613  [9]
 LDCM0297  AC36 HCT 116 C133(0.98)  LDD0614  [9]
 LDCM0298  AC37 HCT 116 C133(0.94)  LDD0615  [9]
 LDCM0299  AC38 HCT 116 C133(1.05)  LDD0616  [9]
 LDCM0300  AC39 HCT 116 C133(1.10)  LDD0617  [9]
 LDCM0301  AC4 HCT 116 C133(1.37)  LDD0618  [9]
 LDCM0302  AC40 HCT 116 C133(1.15)  LDD0619  [9]
 LDCM0303  AC41 HCT 116 C133(0.95)  LDD0620  [9]
 LDCM0304  AC42 HCT 116 C133(1.14)  LDD0621  [9]
 LDCM0305  AC43 HCT 116 C133(1.09)  LDD0622  [9]
 LDCM0306  AC44 HCT 116 C133(1.14)  LDD0623  [9]
 LDCM0307  AC45 HCT 116 C133(1.14)  LDD0624  [9]
 LDCM0308  AC46 HCT 116 C133(1.01)  LDD0625  [9]
 LDCM0309  AC47 HCT 116 C133(1.13)  LDD0626  [9]
 LDCM0310  AC48 HCT 116 C133(1.22)  LDD0627  [9]
 LDCM0311  AC49 HCT 116 C133(1.54)  LDD0628  [9]
 LDCM0312  AC5 HCT 116 C133(1.30)  LDD0629  [9]
 LDCM0313  AC50 HCT 116 C133(1.40)  LDD0630  [9]
 LDCM0314  AC51 HCT 116 C133(1.04)  LDD0631  [9]
 LDCM0315  AC52 HCT 116 C133(1.18)  LDD0632  [9]
 LDCM0316  AC53 HCT 116 C133(1.37)  LDD0633  [9]
 LDCM0317  AC54 HCT 116 C133(1.36)  LDD0634  [9]
 LDCM0318  AC55 HCT 116 C133(1.51)  LDD0635  [9]
 LDCM0319  AC56 HCT 116 C133(1.79)  LDD0636  [9]
 LDCM0320  AC57 HCT 116 C133(1.50)  LDD0637  [9]
 LDCM0321  AC58 HCT 116 C133(1.61)  LDD0638  [9]
 LDCM0322  AC59 HCT 116 C133(1.67)  LDD0639  [9]
 LDCM0323  AC6 HCT 116 C133(1.16)  LDD0640  [9]
 LDCM0324  AC60 HCT 116 C133(1.57)  LDD0641  [9]
 LDCM0325  AC61 HCT 116 C133(1.75)  LDD0642  [9]
 LDCM0326  AC62 HCT 116 C133(1.94)  LDD0643  [9]
 LDCM0327  AC63 HCT 116 C133(1.47)  LDD0644  [9]
 LDCM0328  AC64 HCT 116 C133(1.91)  LDD0645  [9]
 LDCM0329  AC65 HCT 116 C133(1.76)  LDD0646  [9]
 LDCM0330  AC66 HCT 116 C133(1.74)  LDD0647  [9]
 LDCM0331  AC67 HCT 116 C133(1.85)  LDD0648  [9]
 LDCM0332  AC68 HCT 116 C133(1.10)  LDD0649  [9]
 LDCM0333  AC69 HCT 116 C133(1.24)  LDD0650  [9]
 LDCM0334  AC7 HCT 116 C133(1.19)  LDD0651  [9]
 LDCM0335  AC70 HCT 116 C133(0.91)  LDD0652  [9]
 LDCM0336  AC71 HCT 116 C133(1.13)  LDD0653  [9]
 LDCM0337  AC72 HCT 116 C133(1.05)  LDD0654  [9]
 LDCM0338  AC73 HCT 116 C133(1.40)  LDD0655  [9]
 LDCM0339  AC74 HCT 116 C133(1.66)  LDD0656  [9]
 LDCM0340  AC75 HCT 116 C133(1.84)  LDD0657  [9]
 LDCM0341  AC76 HCT 116 C133(1.24)  LDD0658  [9]
 LDCM0342  AC77 HCT 116 C133(1.23)  LDD0659  [9]
 LDCM0343  AC78 HCT 116 C133(1.13)  LDD0660  [9]
 LDCM0344  AC79 HCT 116 C133(1.14)  LDD0661  [9]
 LDCM0345  AC8 HCT 116 C133(1.20)  LDD0662  [9]
 LDCM0346  AC80 HCT 116 C133(1.10)  LDD0663  [9]
 LDCM0347  AC81 HCT 116 C133(1.09)  LDD0664  [9]
 LDCM0348  AC82 HCT 116 C133(1.59)  LDD0665  [9]
 LDCM0349  AC83 HCT 116 C133(1.94)  LDD0666  [9]
 LDCM0350  AC84 HCT 116 C133(1.91)  LDD0667  [9]
 LDCM0351  AC85 HCT 116 C133(1.38)  LDD0668  [9]
 LDCM0352  AC86 HCT 116 C133(1.27)  LDD0669  [9]
 LDCM0353  AC87 HCT 116 C133(1.24)  LDD0670  [9]
 LDCM0354  AC88 HCT 116 C133(1.24)  LDD0671  [9]
 LDCM0355  AC89 HCT 116 C133(1.36)  LDD0672  [9]
 LDCM0357  AC90 HCT 116 C133(1.01)  LDD0674  [9]
 LDCM0358  AC91 HCT 116 C133(1.82)  LDD0675  [9]
 LDCM0359  AC92 HCT 116 C133(1.50)  LDD0676  [9]
 LDCM0360  AC93 HCT 116 C133(1.17)  LDD0677  [9]
 LDCM0361  AC94 HCT 116 C133(1.31)  LDD0678  [9]
 LDCM0362  AC95 HCT 116 C133(1.16)  LDD0679  [9]
 LDCM0363  AC96 HCT 116 C133(1.26)  LDD0680  [9]
 LDCM0364  AC97 HCT 116 C133(1.46)  LDD0681  [9]
 LDCM0365  AC98 HCT 116 C133(1.31)  LDD0682  [9]
 LDCM0366  AC99 HCT 116 C133(0.88)  LDD0683  [9]
 LDCM0248  AKOS034007472 HCT 116 C133(1.20)  LDD0565  [9]
 LDCM0356  AKOS034007680 HCT 116 C133(1.20)  LDD0673  [9]
 LDCM0275  AKOS034007705 HCT 116 C133(1.78)  LDD0592  [9]
 LDCM0156  Aniline NCI-H1299 12.21  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C133(1.12)  LDD0078  [9]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [10]
 LDCM0367  CL1 HCT 116 C133(0.84)  LDD0684  [9]
 LDCM0368  CL10 HCT 116 C133(1.31)  LDD0685  [9]
 LDCM0369  CL100 HCT 116 C133(1.17)  LDD0686  [9]
 LDCM0370  CL101 HCT 116 C133(1.21)  LDD0687  [9]
 LDCM0371  CL102 HCT 116 C133(1.11)  LDD0688  [9]
 LDCM0372  CL103 HCT 116 C133(1.06)  LDD0689  [9]
 LDCM0373  CL104 HCT 116 C133(1.05)  LDD0690  [9]
 LDCM0374  CL105 HCT 116 C133(1.25)  LDD0691  [9]
 LDCM0375  CL106 HCT 116 C133(1.55)  LDD0692  [9]
 LDCM0376  CL107 HCT 116 C133(1.36)  LDD0693  [9]
 LDCM0377  CL108 HCT 116 C133(1.71)  LDD0694  [9]
 LDCM0378  CL109 HCT 116 C133(1.02)  LDD0695  [9]
 LDCM0379  CL11 HCT 116 C133(1.27)  LDD0696  [9]
 LDCM0380  CL110 HCT 116 C133(1.21)  LDD0697  [9]
 LDCM0381  CL111 HCT 116 C133(1.20)  LDD0698  [9]
 LDCM0382  CL112 HCT 116 C133(1.20)  LDD0699  [9]
 LDCM0383  CL113 HCT 116 C133(1.32)  LDD0700  [9]
 LDCM0384  CL114 HCT 116 C133(1.15)  LDD0701  [9]
 LDCM0385  CL115 HCT 116 C133(1.41)  LDD0702  [9]
 LDCM0386  CL116 HCT 116 C133(1.24)  LDD0703  [9]
 LDCM0387  CL117 HCT 116 C133(1.65)  LDD0704  [9]
 LDCM0388  CL118 HCT 116 C133(1.16)  LDD0705  [9]
 LDCM0389  CL119 HCT 116 C133(1.08)  LDD0706  [9]
 LDCM0390  CL12 HCT 116 C133(1.21)  LDD0707  [9]
 LDCM0391  CL120 HCT 116 C133(1.01)  LDD0708  [9]
 LDCM0392  CL121 HCT 116 C133(1.23)  LDD0709  [9]
 LDCM0393  CL122 HCT 116 C133(1.26)  LDD0710  [9]
 LDCM0394  CL123 HCT 116 C133(1.30)  LDD0711  [9]
 LDCM0395  CL124 HCT 116 C133(1.34)  LDD0712  [9]
 LDCM0396  CL125 HCT 116 C133(1.09)  LDD0713  [9]
 LDCM0397  CL126 HCT 116 C133(1.27)  LDD0714  [9]
 LDCM0398  CL127 HCT 116 C133(1.27)  LDD0715  [9]
 LDCM0399  CL128 HCT 116 C133(1.51)  LDD0716  [9]
 LDCM0400  CL13 HCT 116 C133(1.17)  LDD0717  [9]
 LDCM0401  CL14 HCT 116 C133(0.89)  LDD0718  [9]
 LDCM0402  CL15 HCT 116 C133(1.08)  LDD0719  [9]
 LDCM0403  CL16 HCT 116 C133(1.12)  LDD0720  [9]
 LDCM0404  CL17 HCT 116 C133(1.08)  LDD0721  [9]
 LDCM0405  CL18 HCT 116 C133(1.36)  LDD0722  [9]
 LDCM0406  CL19 HCT 116 C133(1.23)  LDD0723  [9]
 LDCM0407  CL2 HCT 116 C133(0.87)  LDD0724  [9]
 LDCM0408  CL20 HCT 116 C133(1.15)  LDD0725  [9]
 LDCM0409  CL21 HCT 116 C133(1.32)  LDD0726  [9]
 LDCM0410  CL22 HCT 116 C133(2.06)  LDD0727  [9]
 LDCM0411  CL23 HCT 116 C133(1.31)  LDD0728  [9]
 LDCM0412  CL24 HCT 116 C133(1.61)  LDD0729  [9]
 LDCM0413  CL25 HCT 116 C133(1.40)  LDD0730  [9]
 LDCM0414  CL26 HCT 116 C133(1.24)  LDD0731  [9]
 LDCM0415  CL27 HCT 116 C133(1.17)  LDD0732  [9]
 LDCM0416  CL28 HCT 116 C133(1.32)  LDD0733  [9]
 LDCM0417  CL29 HCT 116 C133(1.37)  LDD0734  [9]
 LDCM0418  CL3 HCT 116 C133(0.88)  LDD0735  [9]
 LDCM0419  CL30 HCT 116 C133(1.29)  LDD0736  [9]
 LDCM0420  CL31 HEK-293T C133(0.64)  LDD1018  [9]
 LDCM0421  CL32 HCT 116 C133(1.31)  LDD0738  [9]
 LDCM0422  CL33 HCT 116 C133(0.70)  LDD0739  [9]
 LDCM0423  CL34 HCT 116 C133(1.23)  LDD0740  [9]
 LDCM0424  CL35 HCT 116 C133(1.11)  LDD0741  [9]
 LDCM0425  CL36 HCT 116 C133(1.27)  LDD0742  [9]
 LDCM0426  CL37 HCT 116 C133(1.17)  LDD0743  [9]
 LDCM0428  CL39 HCT 116 C133(1.18)  LDD0745  [9]
 LDCM0429  CL4 HCT 116 C133(0.88)  LDD0746  [9]
 LDCM0430  CL40 HCT 116 C133(0.99)  LDD0747  [9]
 LDCM0431  CL41 HCT 116 C133(1.22)  LDD0748  [9]
 LDCM0432  CL42 HCT 116 C133(1.03)  LDD0749  [9]
 LDCM0433  CL43 HCT 116 C133(1.16)  LDD0750  [9]
 LDCM0434  CL44 HCT 116 C133(1.10)  LDD0751  [9]
 LDCM0435  CL45 HCT 116 C133(1.08)  LDD0752  [9]
 LDCM0436  CL46 HCT 116 C133(0.85)  LDD0753  [9]
 LDCM0437  CL47 HCT 116 C133(0.94)  LDD0754  [9]
 LDCM0438  CL48 HCT 116 C133(0.81)  LDD0755  [9]
 LDCM0439  CL49 HCT 116 C133(0.91)  LDD0756  [9]
 LDCM0440  CL5 HCT 116 C133(0.99)  LDD0757  [9]
 LDCM0441  CL50 HCT 116 C133(0.88)  LDD0758  [9]
 LDCM0442  CL51 HCT 116 C133(0.78)  LDD0759  [9]
 LDCM0443  CL52 HCT 116 C133(0.88)  LDD0760  [9]
 LDCM0444  CL53 HCT 116 C133(0.80)  LDD0761  [9]
 LDCM0445  CL54 HCT 116 C133(0.69)  LDD0762  [9]
 LDCM0446  CL55 HCT 116 C133(0.89)  LDD0763  [9]
 LDCM0447  CL56 HCT 116 C133(0.97)  LDD0764  [9]
 LDCM0448  CL57 HCT 116 C133(0.97)  LDD0765  [9]
 LDCM0449  CL58 HCT 116 C133(0.88)  LDD0766  [9]
 LDCM0450  CL59 HCT 116 C133(0.86)  LDD0767  [9]
 LDCM0451  CL6 HCT 116 C133(1.22)  LDD0768  [9]
 LDCM0452  CL60 HCT 116 C133(0.93)  LDD0769  [9]
 LDCM0453  CL61 HCT 116 C133(1.07)  LDD0770  [9]
 LDCM0454  CL62 HCT 116 C133(1.01)  LDD0771  [9]
 LDCM0455  CL63 HCT 116 C133(1.29)  LDD0772  [9]
 LDCM0456  CL64 HCT 116 C133(1.37)  LDD0773  [9]
 LDCM0457  CL65 HCT 116 C133(1.21)  LDD0774  [9]
 LDCM0458  CL66 HCT 116 C133(1.50)  LDD0775  [9]
 LDCM0459  CL67 HCT 116 C133(1.27)  LDD0776  [9]
 LDCM0460  CL68 HCT 116 C133(1.24)  LDD0777  [9]
 LDCM0461  CL69 HCT 116 C133(1.02)  LDD0778  [9]
 LDCM0462  CL7 HCT 116 C133(1.26)  LDD0779  [9]
 LDCM0463  CL70 HCT 116 C133(1.28)  LDD0780  [9]
 LDCM0464  CL71 HCT 116 C133(1.24)  LDD0781  [9]
 LDCM0465  CL72 HCT 116 C133(1.00)  LDD0782  [9]
 LDCM0466  CL73 HCT 116 C133(1.27)  LDD0783  [9]
 LDCM0467  CL74 HCT 116 C133(1.11)  LDD0784  [9]
 LDCM0469  CL76 HCT 116 C133(1.20)  LDD0786  [9]
 LDCM0470  CL77 HCT 116 C133(1.22)  LDD0787  [9]
 LDCM0471  CL78 HCT 116 C133(1.03)  LDD0788  [9]
 LDCM0472  CL79 HCT 116 C133(1.35)  LDD0789  [9]
 LDCM0473  CL8 HCT 116 C133(1.14)  LDD0790  [9]
 LDCM0474  CL80 HCT 116 C133(1.26)  LDD0791  [9]
 LDCM0475  CL81 HCT 116 C133(1.25)  LDD0792  [9]
 LDCM0476  CL82 HCT 116 C133(1.67)  LDD0793  [9]
 LDCM0477  CL83 HCT 116 C133(1.58)  LDD0794  [9]
 LDCM0478  CL84 HCT 116 C133(1.91)  LDD0795  [9]
 LDCM0479  CL85 HCT 116 C133(1.22)  LDD0796  [9]
 LDCM0480  CL86 HCT 116 C133(1.20)  LDD0797  [9]
 LDCM0481  CL87 HCT 116 C133(1.26)  LDD0798  [9]
 LDCM0482  CL88 HCT 116 C133(1.41)  LDD0799  [9]
 LDCM0483  CL89 HCT 116 C133(2.18)  LDD0800  [9]
 LDCM0484  CL9 HCT 116 C133(1.09)  LDD0801  [9]
 LDCM0485  CL90 HCT 116 C133(0.91)  LDD0802  [9]
 LDCM0486  CL91 HCT 116 C133(1.09)  LDD0803  [9]
 LDCM0487  CL92 HCT 116 C133(1.09)  LDD0804  [9]
 LDCM0488  CL93 HCT 116 C133(1.02)  LDD0805  [9]
 LDCM0489  CL94 HCT 116 C133(1.15)  LDD0806  [9]
 LDCM0490  CL95 HCT 116 C133(1.19)  LDD0807  [9]
 LDCM0491  CL96 HCT 116 C133(1.21)  LDD0808  [9]
 LDCM0492  CL97 HCT 116 C133(1.08)  LDD0809  [9]
 LDCM0493  CL98 HCT 116 C133(1.20)  LDD0810  [9]
 LDCM0494  CL99 HCT 116 C133(1.14)  LDD0811  [9]
 LDCM0495  E2913 HEK-293T C133(1.05)  LDD1698  [13]
 LDCM0175  Ethacrynic acid HeLa C133(0.81)  LDD2210  [5]
 LDCM0625  F8 Ramos C133(1.30)  LDD2187  [14]
 LDCM0573  Fragment11 Ramos C133(0.15)  LDD2190  [14]
 LDCM0576  Fragment14 Ramos C133(0.92)  LDD2193  [14]
 LDCM0586  Fragment28 Ramos C133(1.89)  LDD2198  [14]
 LDCM0468  Fragment33 HCT 116 C133(1.10)  LDD0785  [9]
 LDCM0566  Fragment4 Ramos C133(0.39)  LDD2184  [14]
 LDCM0427  Fragment51 HCT 116 C133(1.07)  LDD0744  [9]
 LDCM0569  Fragment7 Ramos C133(0.15)  LDD2186  [14]
 LDCM0116  HHS-0101 DM93 Y42(0.96); Y36(1.84)  LDD0264  [7]
 LDCM0117  HHS-0201 DM93 Y42(0.87); Y36(11.65)  LDD0265  [7]
 LDCM0118  HHS-0301 DM93 Y42(0.93); Y36(1.57)  LDD0266  [7]
 LDCM0119  HHS-0401 DM93 Y42(0.74); Y36(0.97)  LDD0267  [7]
 LDCM0120  HHS-0701 DM93 Y42(1.00); Y36(1.81)  LDD0268  [7]
 LDCM0123  JWB131 DM93 Y42(0.84)  LDD0285  [6]
 LDCM0124  JWB142 DM93 Y42(0.81)  LDD0286  [6]
 LDCM0125  JWB146 DM93 Y42(0.77)  LDD0287  [6]
 LDCM0126  JWB150 DM93 Y42(3.41)  LDD0288  [6]
 LDCM0127  JWB152 DM93 Y42(1.91)  LDD0289  [6]
 LDCM0128  JWB198 DM93 Y42(1.17)  LDD0290  [6]
 LDCM0129  JWB202 DM93 Y42(0.81)  LDD0291  [6]
 LDCM0130  JWB211 DM93 Y42(1.03)  LDD0292  [6]
 LDCM0022  KB02 HCT 116 C133(4.76)  LDD0080  [9]
 LDCM0023  KB03 HCT 116 C133(1.03)  LDD0081  [9]
 LDCM0024  KB05 HCT 116 C133(0.42)  LDD0082  [9]
 LDCM0109  NEM HeLa N.A.  LDD0223  [10]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
NADH dehydrogenase 1 beta subcomplex subunit 7 (NDUFB7) Complex I NDUFB7 subunit family P17568
Tyrosine-protein phosphatase non-receptor type 21 (PTPN21) Protein-tyrosine phosphatase family Q16825
Phosphoribosyl pyrophosphate synthase-associated protein 1 (PRPSAP1) Ribose-phosphate pyrophosphokinase family Q14558
Tripartite motif-containing protein 42 (TRIM42) TRIM/RBCC family Q8IWZ5
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
RNA-binding protein 8A (RBM8A) RBM8A family Q9Y5S9
Transcription factor
Click To Hide/Show 22 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein Aiolos (IKZF3) Ikaros C2H2-type zinc-finger protein family Q9UKT9
RB-associated KRAB zinc finger protein (RBAK) Krueppel C2H2-type zinc-finger protein family Q9NYW8
Zinc finger protein 14 homolog (ZFP14) Krueppel C2H2-type zinc-finger protein family Q9HCL3
Zinc finger protein 19 (ZNF19) Krueppel C2H2-type zinc-finger protein family P17023
Zinc finger protein 398 (ZNF398) Krueppel C2H2-type zinc-finger protein family Q8TD17
Zinc finger protein 438 (ZNF438) Krueppel C2H2-type zinc-finger protein family Q7Z4V0
Zinc finger protein 449 (ZNF449) Krueppel C2H2-type zinc-finger protein family Q6P9G9
Zinc finger protein 547 (ZNF547) Krueppel C2H2-type zinc-finger protein family Q8IVP9
Zinc finger protein 566 (ZNF566) Krueppel C2H2-type zinc-finger protein family Q969W8
Zinc finger protein 57 (ZNF57) Krueppel C2H2-type zinc-finger protein family Q68EA5
Zinc finger protein 620 (ZNF620) Krueppel C2H2-type zinc-finger protein family Q6ZNG0
Zinc finger protein 774 (ZNF774) Krueppel C2H2-type zinc-finger protein family Q6NX45
Zinc finger protein 835 (ZNF835) Krueppel C2H2-type zinc-finger protein family Q9Y2P0
Zinc finger and BTB domain-containing protein 42 (ZBTB42) Krueppel C2H2-type zinc-finger protein family B2RXF5
Telomeric repeat-binding factor 2-interacting protein 1 (TERF2IP) RAP1 family Q9NYB0
Pre-B-cell leukemia transcription factor 4 (PBX4) TALE/PBX homeobox family Q9BYU1
High mobility group protein 20A (HMG20A) . Q9NP66
Proto-oncogene c-Rel (REL) . Q04864
THAP domain-containing protein 7 (THAP7) . Q9BT49
Transcription factor 4 (TCF4) . P15884
Transcriptional adapter 2-alpha (TADA2A) . O75478
Zinc finger protein 426 (ZNF426) . Q9BUY5
Other
Click To Hide/Show 29 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Angiomotin-like protein 2 (AMOTL2) Angiomotin family Q9Y2J4
Calcium-binding and coiled-coil domain-containing protein 2 (CALCOCO2) CALCOCO family Q13137
Segment polarity protein dishevelled homolog DVL-3 (DVL3) DSH family Q92997
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Protein INCA1 (INCA1) INCA family Q0VD86
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Keratin, type II cytoskeletal 75 (KRT75) Intermediate filament family O95678
Peripherin (PRPH) Intermediate filament family P41219
Keratin-associated protein 1-1 (KRTAP1-1) KRTAP type 1 family Q07627
Partitioning defective 6 homolog beta (PARD6B) PAR6 family Q9BYG5
Keratin-associated protein 13-2 (KRTAP13-2) PMG family Q52LG2
RUN domain-containing protein 3A (RUNDC3A) RUNDC3 family Q59EK9
SNW domain-containing protein 1 (SNW1) SNW family Q13573
Speedy protein E4 (SPDYE4) Speedy/Ringo family A6NLX3
Transformer-2 protein homolog alpha (TRA2A) Splicing factor SR family Q13595
Transformer-2 protein homolog beta (TRA2B) Splicing factor SR family P62995
Syntaxin-11 (STX11) Syntaxin family O75558
TLE family member 5 (TLE5) WD repeat Groucho/TLE family Q08117
Caspase recruitment domain-containing protein 10 (CARD10) . Q9BWT7
Coiled-coil domain-containing protein 102B (CCDC102B) . Q68D86
Coiled-coil domain-containing protein 106 (CCDC106) . Q9BWC9
EF-hand domain-containing family member C2 (EFHC2) . Q5JST6
Four and a half LIM domains protein 5 (FHL5) . Q5TD97
G patch domain and ankyrin repeat-containing protein 1 (GPANK1) . O95872
Heat shock factor 2-binding protein (HSF2BP) . O75031
Interactor of HORMAD1 protein 1 (IHO1) . Q8IYA8
Lung adenoma susceptibility protein 2 (LAS2) . Q8IYD9
RNA-binding motif protein, X chromosome (RBMX) . P38159
Zinc finger FYVE domain-containing protein 1 (ZFYVE1) . Q9HBF4

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 From chemoproteomic-detected amino acids to genomic coordinates: insights into precise multi-omic data integration. Mol Syst Biol. 2021 Feb;17(2):e9840. doi: 10.15252/msb.20209840.
Mass spectrometry data entry: PXD022151
5 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
6 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
7 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
8 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
9 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
10 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
11 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
12 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578