Details of the Target

General Information of Target

Target ID LDTP11292
Target Name BOS complex subunit TMEM147 (TMEM147)
Gene Name TMEM147
Gene ID 10430
Synonyms
BOS complex subunit TMEM147; Protein NIFIE 14; Transmembrane protein 147
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAVELGVLLVRPRPGTGLGRVMRTLLLVLWLATRGSALYFHIGETEKKCFIEEIPDETMV
IGNYRTQLYDKQREEYQPATPGLGMFVEVKDPEDKVILARQYGSEGRFTFTSHTPGEHQI
CLHSNSTKFSLFAGGMLRVHLDIQVGEHANDYAEIAAKDKLSELQLRVRQLVEQVEQIQK
EQNYQRWREERFRQTSESTNQRVLWWSILQTLILVAIGVWQMRHLKSFFEAKKLV
Target Bioclass
Transporter and channel
Family
TMEM147 family
Subcellular location
Endoplasmic reticulum membrane
Function
Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes. The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions. Also acts as a negative regulator of CHRM3 function, most likely by interfering with its trafficking to the cell membrane. Negatively regulates CHRM3-mediated calcium mobilization and activation of RPS6KA1/p90RSK activity. Regulates LBR localization to the nucleus inner membrane.
Uniprot ID
Q9BVK8
Ensemble ID
ENST00000222284.10
HGNC ID
HGNC:30414

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
TOV21G SNV: p.E28Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
EA-probe
 Probe Info  		C23(1.08); C23(1.46)  LDD2210  [1]
DBIA
 Probe Info  		C116(1.17); C23(0.93)  LDD0531  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [3]
TFBX
 Probe Info  		N.A.  LDD0027  [4]
IPM
 Probe Info  		C23(0.00); C116(0.00)  LDD0005  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C116(1.17); C23(0.93)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C116(0.99); C23(1.38)  LDD0532  [2]
 LDCM0216  AC100 HCT 116 C116(0.82); C23(0.61)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C116(0.71); C23(0.60)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C116(0.62); C23(0.55)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C116(0.70); C23(0.56)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C116(0.69); C23(0.61)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C116(0.68); C23(0.58)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C116(0.70); C23(0.56)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C116(0.71); C23(0.55)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C116(0.90); C23(0.65)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C116(0.70); C23(0.69)  LDD0542  [2]
 LDCM0226  AC11 HCT 116 C116(1.05); C23(1.23)  LDD0543  [2]
 LDCM0227  AC110 HCT 116 C116(0.75); C23(0.59)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C116(0.73); C23(0.62)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C116(0.71); C23(0.53)  LDD0546  [2]
 LDCM0230  AC113 HCT 116 C116(0.89); C23(1.08)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C116(0.97); C23(0.80)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C116(1.07); C23(0.89)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C116(0.98); C23(0.84)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C116(1.03); C23(0.97)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C116(1.17); C23(0.89)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C116(1.04); C23(0.96)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C116(1.14); C23(1.17)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C116(0.90); C23(0.93)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C116(1.24); C23(1.03)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C116(1.10); C23(0.98)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C116(1.15); C23(1.71)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C116(1.15); C23(0.97)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C116(0.98); C23(0.90)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C116(0.98); C23(0.89)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C116(1.05); C23(0.96)  LDD0562  [2]
 LDCM0246  AC128 HCT 116 C116(1.24); C23(0.89)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C116(1.28); C23(1.06)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C116(1.21); C23(0.79)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C116(1.15); C23(0.85)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C116(1.35); C23(0.91)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C116(1.41); C23(1.03)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C116(1.30); C23(0.83)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C116(1.28); C23(0.79)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C116(1.09); C23(0.95)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C116(1.26); C23(0.95)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C116(1.28); C23(0.91)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C116(1.23); C23(0.86)  LDD0575  [2]
 LDCM0259  AC14 HCT 116 C116(1.07); C23(1.33)  LDD0576  [2]
 LDCM0260  AC140 HCT 116 C116(1.27); C23(0.82)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C116(1.16); C23(0.91)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C116(1.34); C23(1.10)  LDD0579  [2]
 LDCM0263  AC143 HCT 116 C23(0.82); C116(1.01)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C23(0.60); C116(0.86)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C23(0.62); C116(0.93)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C23(0.57); C116(0.83)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C23(0.58); C116(0.90)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C23(0.61); C116(0.81)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C23(0.57); C116(0.81)  LDD0586  [2]
 LDCM0270  AC15 HCT 116 C116(1.05); C23(1.28)  LDD0587  [2]
 LDCM0271  AC150 HCT 116 C23(0.72); C116(1.06)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C23(0.73); C116(1.05)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C23(0.58); C116(0.88)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C23(0.61); C116(0.79)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C116(0.86); C23(0.55)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C116(0.84); C23(0.50)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C116(0.93); C23(0.77)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C116(0.98); C23(0.77)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C116(1.08)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C116(0.92)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C116(1.02)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C23(1.00); C116(1.15)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C116(1.01)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C116(0.98)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C116(1.16)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C116(1.15)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C116(1.06)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C23(0.89); C116(1.06)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C23(0.87); C116(1.01)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C23(0.75); C116(0.91)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C23(0.84); C116(0.95)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C23(0.74); C116(0.92)  LDD0606  [2]
 LDCM0290  AC3 HCT 116 C23(0.95); C116(1.36)  LDD0607  [2]
 LDCM0291  AC30 HCT 116 C23(0.78); C116(0.92)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C23(0.83); C116(1.02)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C23(0.76); C116(0.97)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C23(0.69); C116(0.90)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C23(0.75); C116(0.84)  LDD0612  [2]
 LDCM0296  AC35 HCT 116 C23(0.83); C116(1.04)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C23(0.47); C116(1.11)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C23(0.49); C116(1.12)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C23(0.68); C116(0.99)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C23(0.46); C116(1.16)  LDD0617  [2]
 LDCM0301  AC4 HCT 116 C23(1.00); C116(1.29)  LDD0618  [2]
 LDCM0302  AC40 HCT 116 C23(0.32); C116(1.08)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C23(0.71); C116(1.10)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C23(0.50); C116(1.09)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C23(0.47); C116(1.13)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C23(0.58); C116(1.05)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C23(0.62); C116(1.16)  LDD0624  [2]
 LDCM0308  AC46 HCT 116 C116(0.90); C23(1.00)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C116(0.88); C23(0.97)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C23(0.91); C116(0.95)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C116(0.81); C23(0.91)  LDD0628  [2]
 LDCM0312  AC5 HCT 116 C23(1.10); C116(1.30)  LDD0629  [2]
 LDCM0313  AC50 HCT 116 C116(0.76); C23(0.92)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C116(0.65); C23(0.94)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C116(0.80); C23(0.99)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C116(0.78); C23(0.83)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C116(0.84); C23(0.93)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C23(0.81); C116(0.83)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C116(0.63); C23(0.83)  LDD0636  [2]
 LDCM0320  AC57 HCT 116 C23(0.71); C116(1.12)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C23(0.65); C116(1.03)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C23(0.70); C116(1.25)  LDD0639  [2]
 LDCM0323  AC6 HCT 116 C116(0.91); C23(1.17)  LDD0640  [2]
 LDCM0324  AC60 HCT 116 C23(0.76); C116(1.13)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C23(0.72); C116(1.24)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C23(0.74); C116(1.14)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C23(0.88); C116(1.30)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C23(0.71); C116(1.13)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C23(1.00); C116(1.56)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C23(1.04); C116(1.55)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C23(0.82); C116(1.32)  LDD0648  [2]
 LDCM0332  AC68 HCT 116 C23(0.96); C116(1.03)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C23(0.77); C116(1.11)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C116(1.09); C23(1.17)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C23(0.59); C116(1.03)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C23(0.97); C116(1.03)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C23(0.73); C116(0.97)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C23(0.71); C116(0.94)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C116(1.02); C23(1.20)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C23(0.63); C116(1.01)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C23(0.82); C116(1.10)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C23(0.71); C116(1.06)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C23(0.63); C116(1.03)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C23(0.73); C116(1.05)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C116(0.98); C23(1.29)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C116(0.99); C23(1.08)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C23(0.71); C116(1.29)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C23(0.92); C116(1.11)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C116(0.73)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C116(0.72)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C116(0.74)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C116(0.88)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C116(0.93)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C116(0.85)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C116(0.90)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C116(1.02)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C116(0.78)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C116(0.80)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C116(0.77)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C116(0.83)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C116(0.94)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C116(0.90)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C116(0.77)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C23(0.52); C116(0.58)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C23(0.60); C116(0.68)  LDD0683  [2]
 LDCM0248  AKOS034007472 HCT 116 C116(1.37); C23(1.56)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C116(1.11); C23(1.21)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C116(1.03); C23(1.34)  LDD0592  [2]
 LDCM0367  CL1 HCT 116 C116(1.31); C23(1.35)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C116(1.05); C23(1.21)  LDD0685  [2]
 LDCM0369  CL100 HCT 116 C23(0.87); C116(1.14)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C116(1.00); C23(1.23)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C116(1.08); C23(1.38)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C116(1.13); C23(1.43)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C116(1.12); C23(1.36)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C116(1.07)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C116(0.94)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C116(0.97)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C116(1.10)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C116(0.99)  LDD0695  [2]
 LDCM0379  CL11 HCT 116 C23(1.02); C116(1.28)  LDD0696  [2]
 LDCM0380  CL110 HCT 116 C116(1.06)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C116(1.01)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C23(0.93); C116(1.07)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C23(0.74); C116(0.81)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C23(0.75); C116(1.03)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C23(0.81); C116(0.88)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C23(0.80); C116(0.94)  LDD0703  [2]
 LDCM0387  CL117 HCT 116 C23(0.51); C116(0.98)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C23(0.52); C116(1.15)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C23(0.50); C116(1.08)  LDD0706  [2]
 LDCM0390  CL12 HCT 116 C23(0.82); C116(1.16)  LDD0707  [2]
 LDCM0391  CL120 HCT 116 C23(0.48); C116(1.18)  LDD0708  [2]
 LDCM0392  CL121 HCT 116 C23(0.73); C116(0.81)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C116(0.81); C23(0.94)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C23(0.82); C116(0.90)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C116(0.79); C23(0.79)  LDD0712  [2]
 LDCM0396  CL125 HCT 116 C23(0.99); C116(1.41)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C23(0.86); C116(1.14)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C23(0.91); C116(1.34)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C23(0.65); C116(1.22)  LDD0716  [2]
 LDCM0400  CL13 HCT 116 C23(0.83); C116(1.21)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C116(1.16); C23(1.26)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C23(0.99); C116(1.15)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C116(0.95); C23(1.00)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C116(1.07); C23(1.17)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C23(0.98); C116(1.12)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C116(0.99); C23(1.28)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C23(1.21); C116(1.31)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C116(0.90); C23(1.11)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C116(0.99); C23(1.23)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C23(1.03); C116(1.08)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C116(0.95); C23(1.01)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C116(1.08); C23(1.15)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C116(1.11); C23(1.01)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C116(0.98); C23(1.02)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C116(1.13); C23(1.26)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C116(1.03); C23(1.08)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C116(1.00); C23(1.38)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C116(1.16); C23(1.18)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C116(1.09); C23(1.13)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C116(0.99); C23(1.39)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C116(0.98); C23(0.91)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C116(0.85); C23(0.85)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C116(0.94); C23(1.14)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C116(0.94); C23(1.02)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C116(0.92); C23(1.17)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C116(0.92); C23(1.11)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C116(0.85); C23(0.99)  LDD0745  [2]
 LDCM0429  CL4 HCT 116 C116(1.15); C23(0.88)  LDD0746  [2]
 LDCM0430  CL40 HCT 116 C116(0.94); C23(1.13)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C116(0.99); C23(1.16)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C116(1.00); C23(0.95)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C116(0.84); C23(1.02)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C116(0.91); C23(1.18)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C116(1.04); C23(1.29)  LDD0752  [2]
 LDCM0436  CL46 HCT 116 C116(1.15)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C116(1.09)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C116(1.07)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C116(1.14)  LDD0756  [2]
 LDCM0440  CL5 HCT 116 C116(1.14); C23(1.02)  LDD0757  [2]
 LDCM0441  CL50 HCT 116 C116(1.09)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C116(1.39)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C116(1.20)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C116(0.96)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C116(1.24)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C116(1.24)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C116(1.08)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C116(1.20)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C116(1.12)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C116(1.08)  LDD0767  [2]
 LDCM0451  CL6 HCT 116 C116(1.23); C23(1.34)  LDD0768  [2]
 LDCM0452  CL60 HCT 116 C116(1.07)  LDD0769  [2]
 LDCM0453  CL61 HCT 116 C116(0.90); C23(1.11)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C116(0.92); C23(0.99)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C116(0.96); C23(0.92)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C116(0.83); C23(0.87)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C116(0.93); C23(0.94)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C116(0.85); C23(1.05)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C116(0.80); C23(0.93)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C116(0.92); C23(0.98)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C116(0.90); C23(1.29)  LDD0778  [2]
 LDCM0462  CL7 HCT 116 C116(1.18); C23(1.15)  LDD0779  [2]
 LDCM0463  CL70 HCT 116 C116(0.90); C23(1.10)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C116(0.78); C23(0.99)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C116(0.96); C23(1.08)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C116(0.91); C23(1.11)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C116(0.83); C23(1.04)  LDD0784  [2]
 LDCM0469  CL76 HCT 116 C116(1.20); C23(1.03)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C116(1.01); C23(0.93)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C116(1.09); C23(1.06)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C116(1.14); C23(0.88)  LDD0789  [2]
 LDCM0473  CL8 HCT 116 C116(1.06); C23(1.05)  LDD0790  [2]
 LDCM0474  CL80 HCT 116 C116(1.27); C23(1.07)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C116(1.31); C23(0.98)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C116(1.25); C23(1.03)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C116(1.14); C23(0.95)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C116(1.16); C23(0.99)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C116(1.16); C23(1.19)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C116(1.13); C23(1.14)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C116(1.29); C23(1.04)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C116(1.30); C23(0.97)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C116(1.20); C23(1.11)  LDD0800  [2]
 LDCM0484  CL9 HCT 116 C116(1.10); C23(1.08)  LDD0801  [2]
 LDCM0485  CL90 HCT 116 C116(1.25); C23(1.22)  LDD0802  [2]
 LDCM0486  CL91 HCT 116 C116(1.03); C23(0.81)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C116(1.00); C23(0.77)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C116(1.09); C23(0.92)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C116(0.97); C23(0.92)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C116(1.13); C23(0.92)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C116(1.18); C23(1.01)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C116(1.12); C23(0.94)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C116(1.07); C23(0.91)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C116(1.24); C23(0.87)  LDD0811  [2]
 LDCM0495  E2913 HEK-293T C116(0.80); C23(1.07)  LDD1698  [6]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C116(1.78)  LDD1702  [7]
 LDCM0175  Ethacrynic acid HeLa C23(1.08); C23(1.46)  LDD2210  [1]
 LDCM0625  F8 Ramos C23(1.26)  LDD2187  [8]
 LDCM0572  Fragment10 Ramos C23(1.42)  LDD2189  [8]
 LDCM0573  Fragment11 Ramos C23(2.14)  LDD2190  [8]
 LDCM0574  Fragment12 Ramos C23(1.65)  LDD2191  [8]
 LDCM0575  Fragment13 Ramos C23(1.36)  LDD2192  [8]
 LDCM0576  Fragment14 Ramos C23(3.09)  LDD2193  [8]
 LDCM0580  Fragment21 Ramos C23(1.34)  LDD2195  [8]
 LDCM0582  Fragment23 Ramos C23(0.72)  LDD2196  [8]
 LDCM0578  Fragment27 Ramos C23(1.12)  LDD2197  [8]
 LDCM0586  Fragment28 Ramos C23(1.22)  LDD2198  [8]
 LDCM0588  Fragment30 Ramos C23(1.50)  LDD2199  [8]
 LDCM0589  Fragment31 Ramos C23(1.50)  LDD2200  [8]
 LDCM0590  Fragment32 Ramos C23(1.35)  LDD2201  [8]
 LDCM0468  Fragment33 HCT 116 C116(0.91); C23(0.98)  LDD0785  [2]
 LDCM0596  Fragment38 Ramos C23(2.46)  LDD2203  [8]
 LDCM0427  Fragment51 HCT 116 C116(1.03); C23(1.73)  LDD0744  [2]
 LDCM0610  Fragment52 Ramos C23(1.48)  LDD2204  [8]
 LDCM0614  Fragment56 Ramos C23(1.07)  LDD2205  [8]
 LDCM0569  Fragment7 Ramos C23(1.85)  LDD2186  [8]
 LDCM0022  KB02 HEK-293T C23(0.85); C116(0.92)  LDD1492  [6]
 LDCM0023  KB03 HEK-293T C23(0.96); C116(1.05)  LDD1497  [6]
 LDCM0024  KB05 G361 C67(3.12)  LDD3311  [9]
 LDCM0627  NUDT7-COV-1 HEK-293T C23(0.71)  LDD2206  [10]
 LDCM0628  OTUB2-COV-1 HEK-293T C23(0.68); C116(0.65)  LDD2207  [10]
 LDCM0131  RA190 MM1.R C23(1.72)  LDD0304  [11]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Phosphatidylserine lipase ABHD16A (ABHD16A) ABHD16 family O95870
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) EBP family Q15125
Bis(5'-adenosyl)-triphosphatase ENPP4 (ENPP4) Nucleotide pyrophosphatase/phosphodiesterase family Q9Y6X5
E3 ubiquitin-protein ligase RNF185 (RNF185) . Q96GF1
Transporter and channel
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hepatic sodium/bile acid cotransporter (SLC10A1) Bile acid:sodium symporter (BASS) family Q14973
Clarin-1 (CLRN1) Clarin family P58418
Claudin-7 (CLDN7) Claudin family O95471
Gap junction alpha-8 protein (GJA8) Connexin family P48165
Proton-activated chloride channel (PACC1) Proton-activated chloride channel family Q9H813
Secretory carrier-associated membrane protein 4 (SCAMP4) SCAMP family Q969E2
Solute carrier family 13 member 4 (SLC13A4) SLC13A/DASS transporter family Q9UKG4
Tetraspanin-12 (TSPAN12) Tetraspanin (TM4SF) family O95859
Transmembrane protein 14B (TMEM14B) TMEM14 family Q9NUH8
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-responsive element-binding protein 3-like protein 1 (CREB3L1) BZIP family Q96BA8
Paired-like homeodomain transcription factor LEUTX (LEUTX) Paired homeobox family A8MZ59
GPCR
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
5-hydroxytryptamine receptor 2C (HTR2C) G-protein coupled receptor 1 family P28335
C-X-C chemokine receptor type 2 (CXCR2) G-protein coupled receptor 1 family P25025
Free fatty acid receptor 2 (FFAR2) G-protein coupled receptor 1 family O15552
G-protein coupled receptor 37-like 1 (GPR37L1) G-protein coupled receptor 1 family O60883
G-protein coupled receptor 42 (GPR42) G-protein coupled receptor 1 family O15529
G-protein coupled receptor 61 (GPR61) G-protein coupled receptor 1 family Q9BZJ8
Probable G-protein coupled receptor 101 (GPR101) G-protein coupled receptor 1 family Q96P66
Substance-P receptor (TACR1) G-protein coupled receptor 1 family P25103
Immunoglobulin
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Junctional adhesion molecule A (F11R) Immunoglobulin superfamily Q9Y624
Programmed cell death 1 ligand 2 (PDCD1LG2) BTN/MOG family Q9BQ51
Poliovirus receptor (PVR) Nectin family P15151
B-cell antigen receptor complex-associated protein alpha chain (CD79A) . P11912
Cytokine and receptor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Interleukin-3 receptor subunit alpha (IL3RA) Type I cytokine receptor family P26951
Tumor necrosis factor receptor superfamily member 5 (CD40) . P25942
Other
Click To Hide/Show 15 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ephrin-A4 (EFNA4) Ephrin family P52798
Golgi membrane protein 1 (GOLM1) GOLM family Q8NBJ4
Translation initiation factor IF-3, mitochondrial (MTIF3) IF-3 family Q9H2K0
Low-density lipoprotein receptor class A domain-containing protein 1 (LDLRAD1) LDLR family Q5T700
LHFPL tetraspan subfamily member 2 protein (LHFPL2) LHFP family Q6ZUX7
Nesprin-4 (SYNE4) Nesprin family Q8N205
Regulator of microtubule dynamics protein 3 (RMDN3) RMDN family Q96TC7
Protein shisa-3 homolog (SHISA3) Shisa family A0PJX4
Transmembrane protein 248 (TMEM248) TMEM248 family Q9NWD8
Protein KASH5 (KASH5) . Q8N6L0
Sushi domain-containing protein 3 (SUSD3) . Q96L08
Testis-expressed protein 29 (TEX29) . Q8N6K0
Transmembrane protein 252 (TMEM252) . Q8N6L7
Transmembrane protein 42 (TMEM42) . Q69YG0
Transmembrane protein 52B (TMEM52B) . Q4KMG9

References

1 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
9 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
10 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
11 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.