Details of the Target

General Information of Target

Target ID LDTP12526
Target Name Oligosaccharyltransferase complex subunit OSTC (OSTC)
Gene Name OSTC
Gene ID 58505
Synonyms
Oligosaccharyltransferase complex subunit OSTC; Hydrophobic protein HSF-28
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKKVRLKELESRLQQVDGFEKPKLLLEQYPTRPHIAACMLYTIHNTYDDIENKVVADLGC
GCGVLSIGTAMLGAGLCVGFDIDEDALEIFNRNAEEFELTNIDMVQCDVCLLSNRMSKSF
DTVIMNPPFGTKNNKGTDMAFLKTALEMARTAVYSLHKSSTREHVQKKAAEWKIKIDIIA
ELRYDLPASYKFHKKKSVDIEVDLIRFSF
Target Bioclass
Transporter and channel
Family
OSTC family
Subcellular location
Endoplasmic reticulum
Function
Specific component of the STT3A-containing form of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1.
Uniprot ID
Q9NRP0
Ensemble ID
ENST00000361564.9
HGNC ID
HGNC:24448

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCC1395 SNV: p.F9L DBIA    Probe Info 
KYM1 SNV: p.P23L DBIA    Probe Info 
MSTO211H SNV: p.F9L DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 22 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C14(3.96)  LDD3311  [1]
BTD
 Probe Info  		C14(1.62)  LDD1700  [2]
Jackson_14
 Probe Info  		3.45  LDD0123  [3]
AHL-Pu-1
 Probe Info  		C14(2.02)  LDD0172  [4]
EA-probe
 Probe Info  		C14(1.05); C14(1.13)  LDD2210  [5]
ATP probe
 Probe Info  		K18(0.00); K20(0.00)  LDD0199  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [7]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [7]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [8]
WYneN
 Probe Info  		N.A.  LDD0021  [9]
WYneO
 Probe Info  		N.A.  LDD0022  [9]
Compound 10
 Probe Info  		N.A.  LDD2216  [10]
Compound 11
 Probe Info  		N.A.  LDD2213  [10]
IPM
 Probe Info  		N.A.  LDD0005  [9]
NHS
 Probe Info  		N.A.  LDD0010  [9]
PF-06672131
 Probe Info  		N.A.  LDD0017  [11]
STPyne
 Probe Info  		N.A.  LDD0009  [9]
Acrolein
 Probe Info  		N.A.  LDD0217  [12]
Methacrolein
 Probe Info  		N.A.  LDD0218  [12]
W1
 Probe Info  		N.A.  LDD0236  [13]
NAIA_5
 Probe Info  		N.A.  LDD2223  [14]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-2
 Probe Info  		N.A.  LDD0138  [15]
OEA-DA
 Probe Info  		5.80  LDD0046  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C14(1.11)  LDD2142  [2]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C14(1.12)  LDD2112  [2]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C14(1.12)  LDD2117  [2]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C14(0.84)  LDD2152  [2]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C14(0.83)  LDD2103  [2]
 LDCM0025  4SU-RNA HEK-293T C14(2.02)  LDD0172  [4]
 LDCM0214  AC1 HEK-293T C14(0.89)  LDD1507  [17]
 LDCM0215  AC10 HEK-293T C14(1.04)  LDD1508  [17]
 LDCM0226  AC11 HEK-293T C14(0.92)  LDD1509  [17]
 LDCM0237  AC12 HEK-293T C14(0.89)  LDD1510  [17]
 LDCM0259  AC14 HEK-293T C14(0.85)  LDD1512  [17]
 LDCM0270  AC15 HEK-293T C14(0.87)  LDD1513  [17]
 LDCM0276  AC17 HEK-293T C14(0.93)  LDD1515  [17]
 LDCM0277  AC18 HEK-293T C14(0.98)  LDD1516  [17]
 LDCM0278  AC19 HEK-293T C14(0.97)  LDD1517  [17]
 LDCM0279  AC2 HEK-293T C14(0.99)  LDD1518  [17]
 LDCM0280  AC20 HEK-293T C14(0.97)  LDD1519  [17]
 LDCM0281  AC21 HEK-293T C14(0.98)  LDD1520  [17]
 LDCM0282  AC22 HEK-293T C14(0.92)  LDD1521  [17]
 LDCM0283  AC23 HEK-293T C14(0.94)  LDD1522  [17]
 LDCM0284  AC24 HEK-293T C14(0.96)  LDD1523  [17]
 LDCM0285  AC25 HEK-293T C14(0.93)  LDD1524  [17]
 LDCM0286  AC26 HEK-293T C14(0.99)  LDD1525  [17]
 LDCM0287  AC27 HEK-293T C14(1.03)  LDD1526  [17]
 LDCM0288  AC28 HEK-293T C14(1.02)  LDD1527  [17]
 LDCM0289  AC29 HEK-293T C14(0.99)  LDD1528  [17]
 LDCM0290  AC3 HEK-293T C14(0.93)  LDD1529  [17]
 LDCM0291  AC30 HEK-293T C14(0.93)  LDD1530  [17]
 LDCM0292  AC31 HEK-293T C14(0.96)  LDD1531  [17]
 LDCM0293  AC32 HEK-293T C14(0.96)  LDD1532  [17]
 LDCM0294  AC33 HEK-293T C14(0.90)  LDD1533  [17]
 LDCM0295  AC34 HEK-293T C14(0.93)  LDD1534  [17]
 LDCM0296  AC35 HEK-293T C14(0.88)  LDD1535  [17]
 LDCM0297  AC36 HEK-293T C14(0.88)  LDD1536  [17]
 LDCM0298  AC37 HEK-293T C14(0.95)  LDD1537  [17]
 LDCM0299  AC38 HEK-293T C14(0.94)  LDD1538  [17]
 LDCM0300  AC39 HEK-293T C14(0.90)  LDD1539  [17]
 LDCM0301  AC4 HEK-293T C14(0.95)  LDD1540  [17]
 LDCM0302  AC40 HEK-293T C14(0.91)  LDD1541  [17]
 LDCM0303  AC41 HEK-293T C14(0.86)  LDD1542  [17]
 LDCM0304  AC42 HEK-293T C14(0.93)  LDD1543  [17]
 LDCM0305  AC43 HEK-293T C14(0.92)  LDD1544  [17]
 LDCM0306  AC44 HEK-293T C14(0.93)  LDD1545  [17]
 LDCM0307  AC45 HEK-293T C14(0.94)  LDD1546  [17]
 LDCM0308  AC46 HEK-293T C14(0.91)  LDD1547  [17]
 LDCM0309  AC47 HEK-293T C14(0.88)  LDD1548  [17]
 LDCM0310  AC48 HEK-293T C14(0.91)  LDD1549  [17]
 LDCM0311  AC49 HEK-293T C14(0.90)  LDD1550  [17]
 LDCM0312  AC5 HEK-293T C14(0.98)  LDD1551  [17]
 LDCM0313  AC50 HEK-293T C14(0.96)  LDD1552  [17]
 LDCM0314  AC51 HEK-293T C14(1.00)  LDD1553  [17]
 LDCM0315  AC52 HEK-293T C14(0.91)  LDD1554  [17]
 LDCM0316  AC53 HEK-293T C14(0.96)  LDD1555  [17]
 LDCM0317  AC54 HEK-293T C14(0.96)  LDD1556  [17]
 LDCM0318  AC55 HEK-293T C14(0.87)  LDD1557  [17]
 LDCM0319  AC56 HEK-293T C14(0.93)  LDD1558  [17]
 LDCM0320  AC57 HEK-293T C14(0.98)  LDD1559  [17]
 LDCM0321  AC58 HEK-293T C14(0.93)  LDD1560  [17]
 LDCM0322  AC59 HEK-293T C14(0.96)  LDD1561  [17]
 LDCM0323  AC6 HEK-293T C14(0.94)  LDD1562  [17]
 LDCM0324  AC60 HEK-293T C14(0.90)  LDD1563  [17]
 LDCM0325  AC61 HEK-293T C14(1.00)  LDD1564  [17]
 LDCM0326  AC62 HEK-293T C14(0.94)  LDD1565  [17]
 LDCM0327  AC63 HEK-293T C14(0.89)  LDD1566  [17]
 LDCM0328  AC64 HEK-293T C14(0.92)  LDD1567  [17]
 LDCM0334  AC7 HEK-293T C14(0.89)  LDD1568  [17]
 LDCM0345  AC8 HEK-293T C14(0.88)  LDD1569  [17]
 LDCM0248  AKOS034007472 HEK-293T C14(0.98)  LDD1511  [17]
 LDCM0356  AKOS034007680 HEK-293T C14(0.88)  LDD1570  [17]
 LDCM0275  AKOS034007705 HEK-293T C14(0.93)  LDD1514  [17]
 LDCM0498  BS-3668 MDA-MB-231 C14(0.73)  LDD2091  [2]
 LDCM0630  CCW28-3 231MFP C14(2.55)  LDD2214  [18]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [12]
 LDCM0632  CL-Sc Hep-G2 C14(1.18)  LDD2227  [14]
 LDCM0367  CL1 HEK-293T C14(1.28)  LDD1571  [17]
 LDCM0368  CL10 HEK-293T C14(1.63)  LDD1572  [17]
 LDCM0369  CL100 HEK-293T C14(1.11)  LDD1573  [17]
 LDCM0370  CL101 HEK-293T C14(1.02)  LDD1574  [17]
 LDCM0371  CL102 HEK-293T C14(1.41)  LDD1575  [17]
 LDCM0372  CL103 HEK-293T C14(0.98)  LDD1576  [17]
 LDCM0373  CL104 HEK-293T C14(1.03)  LDD1577  [17]
 LDCM0374  CL105 HEK-293T C14(1.16)  LDD1578  [17]
 LDCM0375  CL106 HEK-293T C14(1.46)  LDD1579  [17]
 LDCM0376  CL107 HEK-293T C14(1.04)  LDD1580  [17]
 LDCM0377  CL108 HEK-293T C14(0.97)  LDD1581  [17]
 LDCM0378  CL109 HEK-293T C14(1.33)  LDD1582  [17]
 LDCM0379  CL11 HEK-293T C14(1.04)  LDD1583  [17]
 LDCM0380  CL110 HEK-293T C14(1.88)  LDD1584  [17]
 LDCM0381  CL111 HEK-293T C14(1.35)  LDD1585  [17]
 LDCM0382  CL112 HEK-293T C14(1.06)  LDD1586  [17]
 LDCM0383  CL113 HEK-293T C14(0.85)  LDD1587  [17]
 LDCM0384  CL114 HEK-293T C14(1.68)  LDD1588  [17]
 LDCM0385  CL115 HEK-293T C14(0.97)  LDD1589  [17]
 LDCM0386  CL116 HEK-293T C14(0.89)  LDD1590  [17]
 LDCM0387  CL117 HEK-293T C14(0.87)  LDD1591  [17]
 LDCM0388  CL118 HEK-293T C14(0.88)  LDD1592  [17]
 LDCM0389  CL119 HEK-293T C14(0.95)  LDD1593  [17]
 LDCM0390  CL12 HEK-293T C14(0.99)  LDD1594  [17]
 LDCM0391  CL120 HEK-293T C14(0.84)  LDD1595  [17]
 LDCM0392  CL121 HEK-293T C14(1.02)  LDD1596  [17]
 LDCM0393  CL122 HEK-293T C14(1.13)  LDD1597  [17]
 LDCM0394  CL123 HEK-293T C14(1.75)  LDD1598  [17]
 LDCM0395  CL124 HEK-293T C14(1.07)  LDD1599  [17]
 LDCM0396  CL125 HEK-293T C14(0.96)  LDD1600  [17]
 LDCM0397  CL126 HEK-293T C14(1.10)  LDD1601  [17]
 LDCM0398  CL127 HEK-293T C14(1.06)  LDD1602  [17]
 LDCM0399  CL128 HEK-293T C14(0.97)  LDD1603  [17]
 LDCM0400  CL13 HEK-293T C14(0.94)  LDD1604  [17]
 LDCM0401  CL14 HEK-293T C14(1.03)  LDD1605  [17]
 LDCM0402  CL15 HEK-293T C14(1.61)  LDD1606  [17]
 LDCM0403  CL16 HEK-293T C14(0.97)  LDD1607  [17]
 LDCM0404  CL17 HEK-293T C14(1.45)  LDD1608  [17]
 LDCM0405  CL18 HEK-293T C14(0.93)  LDD1609  [17]
 LDCM0406  CL19 HEK-293T C14(0.90)  LDD1610  [17]
 LDCM0407  CL2 HEK-293T C14(1.02)  LDD1611  [17]
 LDCM0408  CL20 HEK-293T C14(0.86)  LDD1612  [17]
 LDCM0409  CL21 HEK-293T C14(1.53)  LDD1613  [17]
 LDCM0410  CL22 HEK-293T C14(0.94)  LDD1614  [17]
 LDCM0411  CL23 HEK-293T C14(0.90)  LDD1615  [17]
 LDCM0412  CL24 HEK-293T C14(0.89)  LDD1616  [17]
 LDCM0413  CL25 HEK-293T C14(1.55)  LDD1617  [17]
 LDCM0414  CL26 HEK-293T C14(0.99)  LDD1618  [17]
 LDCM0415  CL27 HEK-293T C14(0.94)  LDD1619  [17]
 LDCM0416  CL28 HEK-293T C14(0.98)  LDD1620  [17]
 LDCM0417  CL29 HEK-293T C14(0.89)  LDD1621  [17]
 LDCM0418  CL3 HEK-293T C14(1.21)  LDD1622  [17]
 LDCM0419  CL30 HEK-293T C14(1.01)  LDD1623  [17]
 LDCM0420  CL31 HEK-293T C14(1.01)  LDD1624  [17]
 LDCM0421  CL32 HEK-293T C14(0.96)  LDD1625  [17]
 LDCM0422  CL33 HEK-293T C14(1.77)  LDD1626  [17]
 LDCM0423  CL34 HEK-293T C14(1.19)  LDD1627  [17]
 LDCM0424  CL35 HEK-293T C14(0.90)  LDD1628  [17]
 LDCM0425  CL36 HEK-293T C14(1.08)  LDD1629  [17]
 LDCM0426  CL37 HEK-293T C14(1.15)  LDD1630  [17]
 LDCM0428  CL39 HEK-293T C14(0.66)  LDD1632  [17]
 LDCM0429  CL4 HEK-293T C14(1.20)  LDD1633  [17]
 LDCM0430  CL40 HEK-293T C14(0.85)  LDD1634  [17]
 LDCM0431  CL41 HEK-293T C14(1.24)  LDD1635  [17]
 LDCM0432  CL42 HEK-293T C14(0.94)  LDD1636  [17]
 LDCM0433  CL43 HEK-293T C14(0.97)  LDD1637  [17]
 LDCM0434  CL44 HEK-293T C14(0.93)  LDD1638  [17]
 LDCM0435  CL45 HEK-293T C14(1.22)  LDD1639  [17]
 LDCM0436  CL46 HEK-293T C14(0.97)  LDD1640  [17]
 LDCM0437  CL47 HEK-293T C14(0.90)  LDD1641  [17]
 LDCM0438  CL48 HEK-293T C14(1.11)  LDD1642  [17]
 LDCM0439  CL49 HEK-293T C14(1.05)  LDD1643  [17]
 LDCM0440  CL5 HEK-293T C14(0.92)  LDD1644  [17]
 LDCM0441  CL50 HEK-293T C14(1.21)  LDD1645  [17]
 LDCM0443  CL52 HEK-293T C14(0.87)  LDD1646  [17]
 LDCM0444  CL53 HEK-293T C14(1.32)  LDD1647  [17]
 LDCM0445  CL54 HEK-293T C14(1.50)  LDD1648  [17]
 LDCM0446  CL55 HEK-293T C14(0.92)  LDD1649  [17]
 LDCM0447  CL56 HEK-293T C14(0.86)  LDD1650  [17]
 LDCM0448  CL57 HEK-293T C14(1.22)  LDD1651  [17]
 LDCM0449  CL58 HEK-293T C14(0.96)  LDD1652  [17]
 LDCM0450  CL59 HEK-293T C14(0.92)  LDD1653  [17]
 LDCM0451  CL6 HEK-293T C14(1.56)  LDD1654  [17]
 LDCM0452  CL60 HEK-293T C14(0.95)  LDD1655  [17]
 LDCM0453  CL61 HEK-293T C14(0.83)  LDD1656  [17]
 LDCM0454  CL62 HEK-293T C14(0.94)  LDD1657  [17]
 LDCM0455  CL63 HEK-293T C14(0.89)  LDD1658  [17]
 LDCM0456  CL64 HEK-293T C14(1.57)  LDD1659  [17]
 LDCM0457  CL65 HEK-293T C14(0.85)  LDD1660  [17]
 LDCM0458  CL66 HEK-293T C14(1.08)  LDD1661  [17]
 LDCM0459  CL67 HEK-293T C14(0.91)  LDD1662  [17]
 LDCM0460  CL68 HEK-293T C14(1.02)  LDD1663  [17]
 LDCM0461  CL69 HEK-293T C14(1.22)  LDD1664  [17]
 LDCM0462  CL7 HEK-293T C14(0.96)  LDD1665  [17]
 LDCM0463  CL70 HEK-293T C14(0.87)  LDD1666  [17]
 LDCM0464  CL71 HEK-293T C14(1.03)  LDD1667  [17]
 LDCM0465  CL72 HEK-293T C14(0.86)  LDD1668  [17]
 LDCM0466  CL73 HEK-293T C14(1.39)  LDD1669  [17]
 LDCM0467  CL74 HEK-293T C14(0.96)  LDD1670  [17]
 LDCM0469  CL76 HEK-293T C14(0.85)  LDD1672  [17]
 LDCM0470  CL77 HEK-293T C14(1.46)  LDD1673  [17]
 LDCM0471  CL78 HEK-293T C14(0.89)  LDD1674  [17]
 LDCM0472  CL79 HEK-293T C14(0.93)  LDD1675  [17]
 LDCM0473  CL8 HEK-293T C14(1.48)  LDD1676  [17]
 LDCM0474  CL80 HEK-293T C14(0.92)  LDD1677  [17]
 LDCM0475  CL81 HEK-293T C14(0.99)  LDD1678  [17]
 LDCM0476  CL82 HEK-293T C14(0.95)  LDD1679  [17]
 LDCM0477  CL83 HEK-293T C14(1.11)  LDD1680  [17]
 LDCM0478  CL84 HEK-293T C14(1.38)  LDD1681  [17]
 LDCM0479  CL85 HEK-293T C14(0.87)  LDD1682  [17]
 LDCM0480  CL86 HEK-293T C14(1.00)  LDD1683  [17]
 LDCM0481  CL87 HEK-293T C14(1.07)  LDD1684  [17]
 LDCM0482  CL88 HEK-293T C14(0.86)  LDD1685  [17]
 LDCM0483  CL89 HEK-293T C14(0.86)  LDD1686  [17]
 LDCM0484  CL9 HEK-293T C14(1.19)  LDD1687  [17]
 LDCM0485  CL90 HEK-293T C14(1.73)  LDD1688  [17]
 LDCM0486  CL91 HEK-293T C14(0.95)  LDD1689  [17]
 LDCM0487  CL92 HEK-293T C14(1.18)  LDD1690  [17]
 LDCM0488  CL93 HEK-293T C14(1.34)  LDD1691  [17]
 LDCM0489  CL94 HEK-293T C14(0.92)  LDD1692  [17]
 LDCM0490  CL95 HEK-293T C14(1.31)  LDD1693  [17]
 LDCM0491  CL96 HEK-293T C14(1.40)  LDD1694  [17]
 LDCM0492  CL97 HEK-293T C14(1.58)  LDD1695  [17]
 LDCM0493  CL98 HEK-293T C14(1.17)  LDD1696  [17]
 LDCM0494  CL99 HEK-293T C14(1.08)  LDD1697  [17]
 LDCM0495  E2913 HEK-293T C14(1.19)  LDD1698  [17]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C14(34.80)  LDD1702  [2]
 LDCM0175  Ethacrynic acid HeLa C14(1.05); C14(1.13)  LDD2210  [5]
 LDCM0625  F8 Ramos C14(0.60)  LDD2187  [19]
 LDCM0572  Fragment10 Ramos C14(1.69)  LDD2189  [19]
 LDCM0573  Fragment11 Ramos C14(0.05)  LDD2190  [19]
 LDCM0574  Fragment12 Ramos C14(1.79)  LDD2191  [19]
 LDCM0575  Fragment13 Ramos C14(1.10)  LDD2192  [19]
 LDCM0576  Fragment14 Ramos C14(1.59)  LDD2193  [19]
 LDCM0579  Fragment20 Ramos C14(3.01)  LDD2194  [19]
 LDCM0580  Fragment21 Ramos C14(1.07)  LDD2195  [19]
 LDCM0582  Fragment23 Ramos C14(0.77)  LDD2196  [19]
 LDCM0578  Fragment27 Ramos C14(0.88)  LDD2197  [19]
 LDCM0586  Fragment28 Ramos C14(1.30)  LDD2198  [19]
 LDCM0588  Fragment30 Ramos C14(1.49)  LDD2199  [19]
 LDCM0589  Fragment31 Ramos C14(0.88)  LDD2200  [19]
 LDCM0590  Fragment32 Ramos C14(1.27)  LDD2201  [19]
 LDCM0468  Fragment33 HEK-293T C14(1.06)  LDD1671  [17]
 LDCM0596  Fragment38 Ramos C14(0.80)  LDD2203  [19]
 LDCM0566  Fragment4 Ramos C14(1.36)  LDD2184  [19]
 LDCM0427  Fragment51 HEK-293T C14(0.93)  LDD1631  [17]
 LDCM0610  Fragment52 Ramos C14(1.50)  LDD2204  [19]
 LDCM0614  Fragment56 Ramos C14(0.86)  LDD2205  [19]
 LDCM0569  Fragment7 Ramos C14(1.18)  LDD2186  [19]
 LDCM0571  Fragment9 Ramos C14(2.96)  LDD2188  [19]
 LDCM0107  IAA HeLa N.A.  LDD0221  [12]
 LDCM0022  KB02 HEK-293T C14(0.78)  LDD1492  [17]
 LDCM0023  KB03 HEK-293T C14(0.80)  LDD1497  [17]
 LDCM0024  KB05 G361 C14(3.96)  LDD3311  [1]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C14(0.93)  LDD2102  [2]
 LDCM0109  NEM HeLa N.A.  LDD0227  [12]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C14(0.81)  LDD2089  [2]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C14(1.22)  LDD2090  [2]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C14(0.96)  LDD2092  [2]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C14(0.94)  LDD2094  [2]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C14(1.03)  LDD2098  [2]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C14(1.13)  LDD2099  [2]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C14(0.79)  LDD2101  [2]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C14(0.95)  LDD2104  [2]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C14(0.65)  LDD2105  [2]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C14(1.48)  LDD2106  [2]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C14(1.03)  LDD2107  [2]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C14(0.91)  LDD2108  [2]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C14(1.39)  LDD2110  [2]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C14(1.07)  LDD2111  [2]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C14(0.85)  LDD2114  [2]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C14(1.15)  LDD2123  [2]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C14(0.47)  LDD2126  [2]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C14(1.00)  LDD2129  [2]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C14(0.35)  LDD2134  [2]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C14(1.41)  LDD2135  [2]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C14(1.70)  LDD2136  [2]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C14(1.11)  LDD2137  [2]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C14(1.62)  LDD1700  [2]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C14(0.90)  LDD2140  [2]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C14(1.21)  LDD2141  [2]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C14(2.17)  LDD2144  [2]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C14(1.11)  LDD2146  [2]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C14(0.49)  LDD2148  [2]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C14(0.86)  LDD2150  [2]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C14(1.28)  LDD2153  [2]
 LDCM0628  OTUB2-COV-1 HEK-293T C14(0.88)  LDD2207  [20]
 LDCM0131  RA190 MM1.R C14(1.21)  LDD0304  [21]
 LDCM0016  Ranjitkar_cp1 MDA-MB-231 3.45  LDD0123  [3]
 LDCM0110  W12 Hep-G2 C14(2.24)  LDD0237  [13]
 LDCM0111  W14 Hep-G2 C14(0.61)  LDD0238  [13]
 LDCM0112  W16 Hep-G2 C14(1.41)  LDD0239  [13]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ectodysplasin-A (EDA) Tumor necrosis factor family Q92838

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
6 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
11 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
12 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
13 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
14 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
15 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
16 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
17 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
18 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
19 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
20 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
21 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.