Details of the Target

General Information of Target

Target ID LDTP09811
Target Name Heat shock protein 105 kDa (HSPH1)
Gene Name HSPH1
Gene ID 10808
Synonyms
HSP105; HSP110; KIAA0201; Heat shock protein 105 kDa; Antigen NY-CO-25; Heat shock 110 kDa protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSREMQDVDLAEVKPLVEKGETITGLLQEFDVQEQDIETLHGSVHVTLCGTPKGNRPVIL
TYHDIGMNHKTCYNPLFNYEDMQEITQHFAVCHVDAPGQQDGAASFPAGYMYPSMDQLAE
MLPGVLQQFGLKSIIGMGTGAGAYILTRFALNNPEMVEGLVLINVNPCAEGWMDWAASKI
SGWTQALPDMVVSHLFGKEEMQSNVEVVHTYRQHIVNDMNPGNLHLFINAYNSRRDLEIE
RPMPGTHTVTLQCPALLVVGDSSPAVDAVVECNSKLDPTKTTLLKMADCGGLPQISQPAK
LAEAFKYFVQGMGYMPSASMTRLMRSRTASGSSVTSLDGTRSRSHTSEGTRSRSHTSEGT
RSRSHTSEGAHLDITPNSGAAGNSAGPKSMEVSC
Target Bioclass
Other
Family
Heat shock protein 70 family
Subcellular location
Cytoplasm
Function
Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release. Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities.
Uniprot ID
Q92598
Ensemble ID
ENST00000320027.10
HGNC ID
HGNC:16969
ChEMBL ID
CHEMBL3706560

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 Deletion: p.E630KfsTer37 DBIA    Probe Info 
HCT15 SNV: p.R265C DBIA    Probe Info 
HG3 SNV: p.P439S DBIA    Probe Info 
IM95 SNV: p.H662R DBIA    Probe Info 
MFE319 SNV: p.A129V DBIA    Probe Info 
NCIH1993 SNV: p.K577N ATP probe    Probe Info 
PANC0403 SNV: p.Q776R DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 50 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
A-EBA
 Probe Info  		3.73  LDD0215  [2]
CY-1
 Probe Info  		100.00  LDD0243  [3]
CY4
 Probe Info  		100.00  LDD0244  [3]
N1
 Probe Info  		100.00  LDD0242  [3]
TH211
 Probe Info  		Y643(8.14)  LDD0257  [4]
TH216
 Probe Info  		Y89(20.00)  LDD0259  [4]
YN-1
 Probe Info  		100.00  LDD0444  [5]
STPyne
 Probe Info  		K221(8.19); K295(2.02); K351(2.38); K356(5.54)  LDD0277  [6]
ONAyne
 Probe Info  		K351(0.00); K703(0.00); K786(0.00)  LDD0273  [6]
Probe 1
 Probe Info  		Y89(136.82); Y184(10.22); Y446(14.81); Y454(11.68)  LDD3495  [7]
AHL-Pu-1
 Probe Info  		C290(3.46)  LDD0168  [8]
EA-probe
 Probe Info  		C34(0.72)  LDD2210  [9]
HHS-482
 Probe Info  		Y184(1.16); Y726(1.13)  LDD0285  [10]
HHS-475
 Probe Info  		Y846(0.76); Y677(0.79); Y322(0.80); Y184(0.87)  LDD0264  [11]
HHS-465
 Probe Info  		Y184(9.39); Y267(10.00)  LDD2237  [12]
DBIA
 Probe Info  		C658(1.14); C650(1.06); C845(1.01); C516(0.98)  LDD0078  [13]
5E-2FA
 Probe Info  		H662(0.00); H329(0.00); H243(0.00); H59(0.00)  LDD2235  [14]
ATP probe
 Probe Info  		K471(0.00); K475(0.00); K655(0.00); K648(0.00)  LDD0199  [15]
4-Iodoacetamidophenylacetylene
 Probe Info  		C34(0.00); C650(0.00); C796(0.00); C658(0.00)  LDD0038  [16]
IA-alkyne
 Probe Info  		C245(0.00); C140(0.00); C290(0.00); C376(0.00)  LDD0032  [17]
IPIAA_H
 Probe Info  		C140(0.00); C270(0.00); C310(0.00)  LDD0030  [18]
IPIAA_L
 Probe Info  		C796(0.00); C845(0.00); C650(0.00); C270(0.00)  LDD0031  [18]
Lodoacetamide azide
 Probe Info  		C34(0.00); C650(0.00); C845(0.00); C796(0.00)  LDD0037  [16]
ATP probe
 Probe Info  		N.A.  LDD0035  [19]
BTD
 Probe Info  		N.A.  LDD0004  [20]
JW-RF-010
 Probe Info  		C380(0.00); C34(0.00); C376(0.00); C13(0.00)  LDD0026  [21]
NAIA_4
 Probe Info  		C380(0.00); C376(0.00); C34(0.00); C167(0.00)  LDD2226  [22]
TFBX
 Probe Info  		C167(0.00); C270(0.00); C376(0.00); C13(0.00)  LDD0027  [21]
WYneN
 Probe Info  		C140(0.00); C658(0.00); C167(0.00); C516(0.00)  LDD0021  [20]
WYneO
 Probe Info  		N.A.  LDD0022  [20]
Compound 10
 Probe Info  		C140(0.00); C167(0.00); C270(0.00); C34(0.00)  LDD2216  [23]
Compound 11
 Probe Info  		C376(0.00); C380(0.00)  LDD2213  [23]
ENE
 Probe Info  		C380(0.00); C658(0.00)  LDD0006  [20]
IPM
 Probe Info  		C845(0.00); C658(0.00)  LDD0005  [20]
NHS
 Probe Info  		K471(0.00); K221(0.00); K194(0.00)  LDD0010  [20]
NPM
 Probe Info  		N.A.  LDD0016  [20]
PF-06672131
 Probe Info  		C167(0.00); C290(0.00)  LDD0017  [24]
SF
 Probe Info  		K430(0.00); Y322(0.00)  LDD0028  [25]
VSF
 Probe Info  		C34(0.00); C516(0.00); C845(0.00)  LDD0007  [20]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [26]
Ox-W18
 Probe Info  		N.A.  LDD2175  [27]
1c-yne
 Probe Info  		K68(0.00); K790(0.00); K53(0.00); K84(0.00)  LDD0228  [28]
1d-yne
 Probe Info  		N.A.  LDD0357  [28]
Acrolein
 Probe Info  		C310(0.00); C845(0.00); C290(0.00); C34(0.00)  LDD0217  [29]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [29]
Methacrolein
 Probe Info  		C658(0.00); C245(0.00); C845(0.00); C796(0.00)  LDD0218  [29]
W1
 Probe Info  		N.A.  LDD0236  [30]
AOyne
 Probe Info  		13.40  LDD0443  [31]
NAIA_5
 Probe Info  		C34(0.00); C650(0.00); C845(0.00); C796(0.00)  LDD2223  [22]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe3
 Probe Info  		5.64  LDD0465  [32]
STS-1
 Probe Info  		N.A.  LDD0136  [33]
STS-2
 Probe Info  		N.A.  LDD0138  [33]
VE-P
 Probe Info  		N.A.  LDD0396  [34]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C796(0.38); C650(0.57); C658(0.65); C845(1.02)  LDD2142  [35]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C796(1.28); C650(0.72); C658(1.00); C845(1.06)  LDD2112  [35]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C796(0.75); C245(0.72); C650(0.62)  LDD2095  [35]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C796(0.93); C650(0.82)  LDD2130  [35]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C796(1.20); C650(0.94); C270(1.60); C658(1.14)  LDD2117  [35]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C245(1.69); C650(1.17); C270(0.89); C658(1.29)  LDD2152  [35]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C650(0.90); C658(0.98); C845(0.96)  LDD2103  [35]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C796(0.55); C245(0.57); C650(0.51); C658(0.38)  LDD2132  [35]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C796(0.71); C650(0.62); C270(0.71)  LDD2131  [35]
 LDCM0025  4SU-RNA HEK-293T C290(3.46)  LDD0168  [8]
 LDCM0026  4SU-RNA+native RNA HEK-293T C650(2.06); C380(2.18); C845(3.30)  LDD0169  [8]
 LDCM0214  AC1 HCT 116 C140(1.57); C167(1.22); C245(0.97); C270(1.50)  LDD0531  [13]
 LDCM0215  AC10 HCT 116 C140(0.69); C167(1.54); C245(0.87); C270(1.17)  LDD0532  [13]
 LDCM0216  AC100 HCT 116 C167(1.01); C245(0.86); C270(0.57); C290(0.87)  LDD0533  [13]
 LDCM0217  AC101 HCT 116 C167(0.78); C245(0.79); C270(0.79); C290(0.96)  LDD0534  [13]
 LDCM0218  AC102 HCT 116 C167(0.73); C245(0.77); C270(0.69); C290(0.88)  LDD0535  [13]
 LDCM0219  AC103 HCT 116 C167(0.66); C245(0.64); C270(0.62); C290(0.83)  LDD0536  [13]
 LDCM0220  AC104 HCT 116 C167(0.74); C245(0.71); C270(0.63); C290(0.83)  LDD0537  [13]
 LDCM0221  AC105 HCT 116 C167(0.74); C245(0.63); C270(0.50); C290(0.78)  LDD0538  [13]
 LDCM0222  AC106 HCT 116 C167(0.71); C245(0.68); C270(0.61); C290(0.83)  LDD0539  [13]
 LDCM0223  AC107 HCT 116 C167(0.63); C245(0.98); C270(0.49); C290(0.93)  LDD0540  [13]
 LDCM0224  AC108 HCT 116 C167(0.61); C245(0.75); C270(0.60); C290(0.77)  LDD0541  [13]
 LDCM0225  AC109 HCT 116 C167(0.73); C245(0.81); C270(1.02); C290(0.76)  LDD0542  [13]
 LDCM0226  AC11 HCT 116 C140(0.75); C167(1.67); C245(0.80); C270(1.25)  LDD0543  [13]
 LDCM0227  AC110 HCT 116 C167(0.65); C245(0.83); C270(0.80); C290(0.78)  LDD0544  [13]
 LDCM0228  AC111 HCT 116 C167(0.64); C245(0.82); C270(0.66); C290(0.79)  LDD0545  [13]
 LDCM0229  AC112 HCT 116 C167(0.66); C245(0.93); C270(0.54); C290(0.85)  LDD0546  [13]
 LDCM0230  AC113 HCT 116 C167(1.97); C245(1.10); C270(1.28); C290(1.08)  LDD0547  [13]
 LDCM0231  AC114 HCT 116 C167(2.07); C245(0.96); C270(0.86); C290(0.95)  LDD0548  [13]
 LDCM0232  AC115 HCT 116 C167(2.00); C245(0.87); C270(0.81); C290(1.06)  LDD0549  [13]
 LDCM0233  AC116 HCT 116 C167(1.86); C245(0.88); C270(0.77); C290(1.08)  LDD0550  [13]
 LDCM0234  AC117 HCT 116 C167(1.91); C245(0.88); C270(0.87); C290(1.13)  LDD0551  [13]
 LDCM0235  AC118 HCT 116 C167(1.99); C245(0.99); C270(0.95); C290(1.07)  LDD0552  [13]
 LDCM0236  AC119 HCT 116 C167(1.90); C245(0.86); C270(0.84); C290(1.01)  LDD0553  [13]
 LDCM0237  AC12 HCT 116 C140(1.05); C167(1.45); C245(1.12); C270(1.28)  LDD0554  [13]
 LDCM0238  AC120 HCT 116 C167(2.17); C245(0.88); C270(0.96); C290(1.03)  LDD0555  [13]
 LDCM0239  AC121 HCT 116 C167(1.97); C245(0.91); C270(0.90); C290(1.12)  LDD0556  [13]
 LDCM0240  AC122 HCT 116 C167(2.01); C245(0.99); C270(1.08); C290(1.06)  LDD0557  [13]
 LDCM0241  AC123 HCT 116 C167(2.06); C245(0.84); C270(1.20); C290(0.95)  LDD0558  [13]
 LDCM0242  AC124 HCT 116 C167(2.05); C245(0.94); C270(0.79); C290(1.06)  LDD0559  [13]
 LDCM0243  AC125 HCT 116 C167(1.93); C245(0.97); C270(0.83); C290(1.01)  LDD0560  [13]
 LDCM0244  AC126 HCT 116 C167(1.74); C245(0.94); C270(0.79); C290(1.08)  LDD0561  [13]
 LDCM0245  AC127 HCT 116 C167(1.95); C245(0.80); C270(0.85); C290(0.99)  LDD0562  [13]
 LDCM0246  AC128 HCT 116 C140(0.42); C167(0.46); C245(0.55); C270(0.51)  LDD0563  [13]
 LDCM0247  AC129 HCT 116 C140(0.73); C167(1.03); C245(1.03); C270(1.25)  LDD0564  [13]
 LDCM0249  AC130 HCT 116 C140(0.75); C167(1.00); C245(0.94); C270(0.94)  LDD0566  [13]
 LDCM0250  AC131 HCT 116 C140(1.86); C167(1.22); C245(1.01); C270(0.99)  LDD0567  [13]
 LDCM0251  AC132 HCT 116 C140(1.23); C167(1.10); C245(1.17); C270(1.26)  LDD0568  [13]
 LDCM0252  AC133 HCT 116 C140(1.25); C167(1.06); C245(1.01); C270(1.12)  LDD0569  [13]
 LDCM0253  AC134 HCT 116 C140(0.90); C167(0.85); C245(0.87); C270(0.99)  LDD0570  [13]
 LDCM0254  AC135 HCT 116 C140(0.85); C167(0.79); C245(0.95); C270(0.94)  LDD0571  [13]
 LDCM0255  AC136 HCT 116 C140(0.82); C167(1.00); C245(1.02); C270(1.09)  LDD0572  [13]
 LDCM0256  AC137 HCT 116 C140(1.31); C167(1.15); C245(1.14); C270(1.36)  LDD0573  [13]
 LDCM0257  AC138 HCT 116 C140(0.95); C167(1.01); C245(1.07); C270(1.11)  LDD0574  [13]
 LDCM0258  AC139 HCT 116 C140(0.94); C167(1.04); C245(1.01); C270(1.19)  LDD0575  [13]
 LDCM0259  AC14 HCT 116 C140(0.80); C167(0.95); C245(0.96); C270(1.26)  LDD0576  [13]
 LDCM0260  AC140 HCT 116 C140(0.85); C167(0.83); C245(0.98); C270(1.11)  LDD0577  [13]
 LDCM0261  AC141 HCT 116 C140(0.89); C167(0.96); C245(0.98); C270(1.20)  LDD0578  [13]
 LDCM0262  AC142 HCT 116 C140(1.65); C167(1.34); C245(1.29); C270(1.67)  LDD0579  [13]
 LDCM0263  AC143 HCT 116 C140(1.08); C245(1.09); C270(0.54); C290(0.83)  LDD0580  [13]
 LDCM0264  AC144 HCT 116 C140(0.54); C270(0.54); C290(0.67); C245(0.89)  LDD0581  [13]
 LDCM0265  AC145 HCT 116 C290(0.79); C140(0.85); C376(0.96); C270(0.98)  LDD0582  [13]
 LDCM0266  AC146 HCT 116 C270(0.64); C658(0.91); C290(0.94); C140(1.07)  LDD0583  [13]
 LDCM0267  AC147 HCT 116 C270(0.61); C290(0.72); C140(0.74); C245(0.92)  LDD0584  [13]
 LDCM0268  AC148 HCT 116 C140(0.19); C270(0.20); C290(0.51); C245(0.56)  LDD0585  [13]
 LDCM0269  AC149 HCT 116 C270(0.46); C140(0.55); C290(0.79); C245(0.88)  LDD0586  [13]
 LDCM0270  AC15 HCT 116 C376(0.78); C245(0.78); C380(0.80); C140(0.82)  LDD0587  [13]
 LDCM0271  AC150 HCT 116 C270(0.64); C658(0.90); C290(0.97); C845(1.02)  LDD0588  [13]
 LDCM0272  AC151 HCT 116 C270(0.70); C140(0.79); C290(0.80); C380(1.00)  LDD0589  [13]
 LDCM0273  AC152 HCT 116 C270(0.44); C140(0.53); C290(0.74); C245(0.76)  LDD0590  [13]
 LDCM0274  AC153 HCT 116 C270(0.15); C140(0.18); C290(0.58); C245(0.59)  LDD0591  [13]
 LDCM0621  AC154 HCT 116 C140(0.67); C245(0.95); C270(0.70); C290(0.80)  LDD2158  [13]
 LDCM0622  AC155 HCT 116 C140(0.80); C245(0.96); C270(0.66); C290(0.91)  LDD2159  [13]
 LDCM0623  AC156 HCT 116 C140(1.35); C245(1.02); C270(0.92); C290(0.83)  LDD2160  [13]
 LDCM0624  AC157 HCT 116 C140(1.12); C245(1.09); C270(1.03); C290(0.74)  LDD2161  [13]
 LDCM0276  AC17 HCT 116 C140(0.79); C270(0.93); C290(0.95); C245(0.95)  LDD0593  [13]
 LDCM0277  AC18 HCT 116 C140(0.59); C380(0.75); C376(0.87); C245(0.89)  LDD0594  [13]
 LDCM0278  AC19 HCT 116 C140(0.71); C270(0.85); C245(0.88); C290(1.05)  LDD0595  [13]
 LDCM0279  AC2 HCT 116 C380(0.81); C376(0.85); C245(0.90); C34(0.91)  LDD0596  [13]
 LDCM0280  AC20 HCT 116 C167(0.72); C140(0.74); C270(0.87); C245(0.92)  LDD0597  [13]
 LDCM0281  AC21 HCT 116 C140(0.68); C270(0.90); C380(0.93); C245(0.95)  LDD0598  [13]
 LDCM0282  AC22 HCT 116 C270(0.88); C140(0.90); C167(0.93); C245(0.95)  LDD0599  [13]
 LDCM0283  AC23 HCT 116 C140(0.66); C167(0.77); C245(0.84); C270(0.85)  LDD0600  [13]
 LDCM0284  AC24 HCT 116 C270(0.72); C140(0.85); C167(0.89); C245(0.95)  LDD0601  [13]
 LDCM0285  AC25 HCT 116 C376(0.78); C167(0.83); C290(0.94); C245(0.95)  LDD0602  [13]
 LDCM0286  AC26 HCT 116 C167(0.76); C376(0.78); C140(0.92); C270(0.95)  LDD0603  [13]
 LDCM0287  AC27 HCT 116 C167(0.81); C270(0.81); C376(0.82); C245(0.95)  LDD0604  [13]
 LDCM0288  AC28 HCT 116 C376(0.72); C167(0.74); C270(0.82); C245(0.91)  LDD0605  [13]
 LDCM0289  AC29 HCT 116 C376(0.72); C270(0.83); C167(0.84); C140(0.87)  LDD0606  [13]
 LDCM0290  AC3 HCT 116 C380(0.84); C376(0.86); C34(0.89); C140(0.89)  LDD0607  [13]
 LDCM0291  AC30 HCT 116 C167(0.76); C376(0.76); C140(0.77); C270(0.87)  LDD0608  [13]
 LDCM0292  AC31 HCT 116 C376(0.83); C167(0.85); C270(0.98); C140(1.01)  LDD0609  [13]
 LDCM0293  AC32 HCT 116 C167(0.73); C140(0.73); C270(0.75); C376(0.82)  LDD0610  [13]
 LDCM0294  AC33 HCT 116 C270(0.69); C245(0.86); C376(0.87); C167(0.90)  LDD0611  [13]
 LDCM0295  AC34 HCT 116 C270(0.62); C245(0.75); C376(0.85); C290(0.94)  LDD0612  [13]
 LDCM0296  AC35 HCT 116 C34(0.77); C516(0.80); C650(0.85); C845(0.86)  LDD0613  [13]
 LDCM0297  AC36 HCT 116 C34(0.81); C516(0.90); C658(0.93); C650(0.93)  LDD0614  [13]
 LDCM0298  AC37 HCT 116 C376(0.81); C516(0.83); C650(0.85); C34(0.86)  LDD0615  [13]
 LDCM0299  AC38 HCT 116 C658(0.89); C34(0.91); C845(0.93); C380(0.93)  LDD0616  [13]
 LDCM0300  AC39 HCT 116 C376(0.65); C380(0.80); C34(0.82); C140(0.88)  LDD0617  [13]
 LDCM0301  AC4 HCT 116 C380(0.75); C376(0.78); C34(0.91); C140(0.92)  LDD0618  [13]
 LDCM0302  AC40 HCT 116 C376(0.62); C140(0.63); C245(0.75); C380(0.80)  LDD0619  [13]
 LDCM0303  AC41 HCT 116 C376(0.82); C34(0.86); C516(0.91); C140(0.92)  LDD0620  [13]
 LDCM0304  AC42 HCT 116 C376(0.85); C140(0.85); C380(0.86); C34(0.88)  LDD0621  [13]
 LDCM0305  AC43 HCT 116 C34(0.89); C380(0.93); C376(0.95); C516(1.00)  LDD0622  [13]
 LDCM0306  AC44 HCT 116 C376(0.75); C140(0.77); C34(0.89); C516(0.90)  LDD0623  [13]
 LDCM0307  AC45 HCT 116 C140(0.51); C376(0.56); C245(0.71); C380(0.83)  LDD0624  [13]
 LDCM0308  AC46 HCT 116 C658(0.99); C167(1.02); C245(1.03); C270(1.04)  LDD0625  [13]
 LDCM0309  AC47 HCT 116 C140(0.86); C376(0.87); C380(0.93); C845(1.00)  LDD0626  [13]
 LDCM0310  AC48 HCT 116 C167(1.01); C845(1.01); C34(1.12); C658(1.12)  LDD0627  [13]
 LDCM0311  AC49 HCT 116 C140(0.27); C270(0.45); C245(0.56); C376(0.64)  LDD0628  [13]
 LDCM0312  AC5 HCT 116 C380(0.72); C376(0.76); C140(0.86); C34(0.86)  LDD0629  [13]
 LDCM0313  AC50 HCT 116 C140(0.32); C270(0.52); C245(0.61); C290(0.77)  LDD0630  [13]
 LDCM0314  AC51 HCT 116 C658(0.87); C845(0.90); C516(0.91); C34(1.03)  LDD0631  [13]
 LDCM0315  AC52 HCT 116 C376(0.85); C245(0.88); C140(0.90); C380(0.95)  LDD0632  [13]
 LDCM0316  AC53 HCT 116 C140(0.58); C270(0.71); C245(0.74); C376(0.84)  LDD0633  [13]
 LDCM0317  AC54 HCT 116 C140(0.52); C270(0.71); C245(0.72); C376(0.78)  LDD0634  [13]
 LDCM0318  AC55 HCT 116 C140(0.28); C245(0.56); C376(0.61); C380(0.66)  LDD0635  [13]
 LDCM0319  AC56 HCT 116 C140(0.21); C270(0.47); C245(0.49); C376(0.61)  LDD0636  [13]
 LDCM0320  AC57 HCT 116 C140(0.67); C167(0.84); C376(0.88); C380(0.92)  LDD0637  [13]
 LDCM0321  AC58 HCT 116 C270(0.77); C167(0.78); C140(0.89); C380(0.91)  LDD0638  [13]
 LDCM0322  AC59 HCT 116 C140(0.47); C167(0.55); C376(0.66); C380(0.72)  LDD0639  [13]
 LDCM0323  AC6 HCT 116 C380(0.82); C376(0.82); C140(0.83); C270(0.86)  LDD0640  [13]
 LDCM0324  AC60 HCT 116 C245(0.90); C140(0.93); C167(0.95); C376(0.96)  LDD0641  [13]
 LDCM0325  AC61 HCT 116 C245(1.03); C376(1.11); C34(1.11); C270(1.16)  LDD0642  [13]
 LDCM0326  AC62 HCT 116 C140(0.40); C167(0.42); C376(0.63); C380(0.66)  LDD0643  [13]
 LDCM0327  AC63 HCT 116 C167(0.78); C140(0.81); C245(0.93); C380(0.93)  LDD0644  [13]
 LDCM0328  AC64 HCT 116 C140(0.48); C167(0.52); C376(0.66); C380(0.69)  LDD0645  [13]
 LDCM0329  AC65 HCT 116 C140(0.73); C167(0.78); C376(0.79); C380(0.81)  LDD0646  [13]
 LDCM0330  AC66 HCT 116 C270(0.96); C376(0.96); C140(0.97); C380(0.99)  LDD0647  [13]
 LDCM0331  AC67 HCT 116 C140(0.20); C167(0.25); C376(0.45); C380(0.46)  LDD0648  [13]
 LDCM0332  AC68 HCT 116 C167(0.83); C376(0.86); C650(0.88); C140(0.91)  LDD0649  [13]
 LDCM0333  AC69 HCT 116 C140(0.67); C650(0.91); C290(0.92); C376(0.93)  LDD0650  [13]
 LDCM0334  AC7 HCT 116 C376(0.76); C380(0.77); C245(0.92); C34(0.94)  LDD0651  [13]
 LDCM0335  AC70 HCT 116 C140(0.22); C270(0.40); C376(0.47); C245(0.49)  LDD0652  [13]
 LDCM0336  AC71 HCT 116 C34(0.81); C650(0.82); C270(0.93); C140(1.00)  LDD0653  [13]
 LDCM0337  AC72 HCT 116 C140(0.65); C270(0.82); C245(0.86); C380(0.87)  LDD0654  [13]
 LDCM0338  AC73 HCT 116 C140(0.19); C270(0.27); C245(0.37); C376(0.49)  LDD0655  [13]
 LDCM0339  AC74 HCT 116 C140(0.23); C270(0.28); C245(0.43); C376(0.47)  LDD0656  [13]
 LDCM0340  AC75 HCT 116 C140(0.18); C270(0.29); C245(0.36); C376(0.49)  LDD0657  [13]
 LDCM0341  AC76 HCT 116 C140(0.40); C270(0.44); C376(0.60); C167(0.65)  LDD0658  [13]
 LDCM0342  AC77 HCT 116 C140(0.37); C270(0.49); C245(0.63); C376(0.70)  LDD0659  [13]
 LDCM0343  AC78 HCT 116 C140(0.97); C34(1.03); C650(1.03); C290(1.08)  LDD0660  [13]
 LDCM0344  AC79 HCT 116 C140(0.63); C376(0.85); C34(0.91); C380(0.96)  LDD0661  [13]
 LDCM0345  AC8 HCT 116 C380(0.72); C376(0.74); C140(0.80); C167(0.86)  LDD0662  [13]
 LDCM0346  AC80 HCT 116 C140(0.58); C376(0.71); C270(0.72); C380(0.77)  LDD0663  [13]
 LDCM0347  AC81 HCT 116 C140(0.74); C380(0.83); C34(0.85); C290(0.93)  LDD0664  [13]
 LDCM0348  AC82 HCT 116 C140(0.17); C270(0.35); C245(0.38); C376(0.47)  LDD0665  [13]
 LDCM0349  AC83 HCT 116 C140(0.23); C245(0.38); C376(0.52); C380(0.58)  LDD0666  [13]
 LDCM0350  AC84 HCT 116 C140(0.36); C245(0.54); C380(0.59); C270(0.61)  LDD0667  [13]
 LDCM0351  AC85 HCT 116 C140(0.83); C380(0.83); C245(0.84); C270(0.85)  LDD0668  [13]
 LDCM0352  AC86 HCT 116 C140(0.62); C270(0.71); C380(0.78); C245(0.79)  LDD0669  [13]
 LDCM0353  AC87 HCT 116 C290(0.89); C380(0.91); C140(0.93); C270(0.97)  LDD0670  [13]
 LDCM0354  AC88 HCT 116 C380(0.75); C245(0.76); C376(0.79); C270(0.86)  LDD0671  [13]
 LDCM0355  AC89 HCT 116 C140(0.58); C245(0.62); C380(0.71); C270(0.72)  LDD0672  [13]
 LDCM0357  AC90 HCT 116 C380(0.80); C290(0.89); C845(0.90); C140(0.95)  LDD0674  [13]
 LDCM0358  AC91 HCT 116 C140(0.23); C245(0.32); C376(0.54); C270(0.57)  LDD0675  [13]
 LDCM0359  AC92 HCT 116 C140(0.30); C245(0.43); C270(0.49); C376(0.50)  LDD0676  [13]
 LDCM0360  AC93 HCT 116 C140(0.59); C245(0.74); C270(0.82); C380(0.84)  LDD0677  [13]
 LDCM0361  AC94 HCT 116 C245(0.93); C290(0.96); C140(0.98); C270(0.99)  LDD0678  [13]
 LDCM0362  AC95 HCT 116 C290(0.89); C380(1.02); C650(1.08); C845(1.09)  LDD0679  [13]
 LDCM0363  AC96 HCT 116 C140(0.61); C245(0.77); C270(0.79); C376(0.89)  LDD0680  [13]
 LDCM0364  AC97 HCT 116 C140(0.47); C245(0.51); C270(0.70); C380(0.70)  LDD0681  [13]
 LDCM0365  AC98 HCT 116 C167(0.24); C376(0.34); C380(0.37); C270(0.37)  LDD0682  [13]
 LDCM0366  AC99 HCT 116 C270(0.65); C380(0.65); C376(0.68); C167(0.76)  LDD0683  [13]
 LDCM0545  Acetamide MDA-MB-231 C796(0.68); C650(0.62); C658(0.66)  LDD2138  [35]
 LDCM0520  AKOS000195272 MDA-MB-231 C796(0.88); C650(0.85); C270(0.86); C845(0.83)  LDD2113  [35]
 LDCM0248  AKOS034007472 HCT 116 C140(1.07); C167(1.42); C245(0.98); C270(1.38)  LDD0565  [13]
 LDCM0356  AKOS034007680 HCT 116 C140(0.72); C376(0.76); C380(0.80); C34(0.91)  LDD0673  [13]
 LDCM0275  AKOS034007705 HCT 116 C140(0.34); C245(0.53); C376(0.53); C380(0.56)  LDD0592  [13]
 LDCM0156  Aniline NCI-H1299 13.40  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C658(1.14); C650(1.06); C845(1.01); C516(0.98)  LDD0078  [13]
 LDCM0498  BS-3668 MDA-MB-231 C796(0.60); C650(0.64); C270(1.14); C140(0.83)  LDD2091  [35]
 LDCM0630  CCW28-3 231MFP C34(1.74); C658(1.36)  LDD2214  [36]
 LDCM0108  Chloroacetamide HeLa C167(0.00); C310(0.00); C245(0.00); C658(0.00)  LDD0222  [29]
 LDCM0632  CL-Sc Hep-G2 C34(20.00); C845(1.91); C845(1.52); C658(0.96)  LDD2227  [22]
 LDCM0367  CL1 HCT 116 C167(0.68); C140(0.84); C845(0.85); C658(0.86)  LDD0684  [13]
 LDCM0368  CL10 HCT 116 C270(0.74); C245(0.75); C140(0.76); C376(0.79)  LDD0685  [13]
 LDCM0369  CL100 HCT 116 C380(0.78); C376(0.81); C140(0.93); C658(0.95)  LDD0686  [13]
 LDCM0370  CL101 HCT 116 C140(0.81); C245(0.85); C270(0.87); C380(0.90)  LDD0687  [13]
 LDCM0371  CL102 HCT 116 C380(0.83); C34(0.94); C376(0.95); C140(0.96)  LDD0688  [13]
 LDCM0372  CL103 HCT 116 C245(0.79); C140(0.88); C380(0.89); C650(0.91)  LDD0689  [13]
 LDCM0373  CL104 HCT 116 C245(0.85); C140(0.88); C34(0.99); C845(1.00)  LDD0690  [13]
 LDCM0374  CL105 HCT 116 C140(0.60); C167(0.88); C245(0.98); C270(1.00)  LDD0691  [13]
 LDCM0375  CL106 HCT 116 C167(0.55); C140(0.71); C376(0.98); C380(0.98)  LDD0692  [13]
 LDCM0376  CL107 HCT 116 C140(0.48); C270(0.88); C245(0.89); C167(0.90)  LDD0693  [13]
 LDCM0377  CL108 HCT 116 C140(0.42); C270(0.55); C380(0.73); C376(0.75)  LDD0694  [13]
 LDCM0378  CL109 HCT 116 C140(0.58); C270(0.69); C167(0.86); C245(0.86)  LDD0695  [13]
 LDCM0379  CL11 HCT 116 C140(0.53); C167(0.60); C376(0.61); C270(0.62)  LDD0696  [13]
 LDCM0380  CL110 HCT 116 C140(0.56); C270(0.67); C167(0.68); C245(0.78)  LDD0697  [13]
 LDCM0381  CL111 HCT 116 C140(0.61); C270(0.74); C245(0.90); C290(1.03)  LDD0698  [13]
 LDCM0382  CL112 HCT 116 C167(0.72); C376(0.78); C140(0.88); C380(0.90)  LDD0699  [13]
 LDCM0383  CL113 HCT 116 C140(0.76); C167(0.79); C376(0.84); C270(0.87)  LDD0700  [13]
 LDCM0384  CL114 HCT 116 C140(0.73); C167(0.76); C376(0.82); C270(0.95)  LDD0701  [13]
 LDCM0385  CL115 HCT 116 C376(0.71); C140(0.80); C270(0.80); C167(0.82)  LDD0702  [13]
 LDCM0386  CL116 HCT 116 C376(0.80); C167(0.85); C270(0.90); C140(0.98)  LDD0703  [13]
 LDCM0387  CL117 HCT 116 C140(0.24); C245(0.34); C376(0.44); C270(0.55)  LDD0704  [13]
 LDCM0388  CL118 HCT 116 C376(0.83); C380(0.87); C34(0.87); C140(0.88)  LDD0705  [13]
 LDCM0389  CL119 HCT 116 C376(0.75); C140(0.76); C380(0.83); C34(0.90)  LDD0706  [13]
 LDCM0390  CL12 HCT 116 C167(0.35); C140(0.40); C376(0.56); C270(0.57)  LDD0707  [13]
 LDCM0391  CL120 HCT 116 C34(0.82); C376(0.83); C290(0.91); C380(0.92)  LDD0708  [13]
 LDCM0392  CL121 HCT 116 C380(0.80); C290(0.92); C245(0.97); C376(0.98)  LDD0709  [13]
 LDCM0393  CL122 HCT 116 C376(0.99); C167(1.00); C270(1.00); C380(1.03)  LDD0710  [13]
 LDCM0394  CL123 HCT 116 C140(0.52); C270(0.61); C245(0.63); C380(0.73)  LDD0711  [13]
 LDCM0395  CL124 HCT 116 C140(0.36); C245(0.55); C270(0.56); C376(0.64)  LDD0712  [13]
 LDCM0396  CL125 HCT 116 C34(0.95); C140(0.97); C376(1.00); C845(1.01)  LDD0713  [13]
 LDCM0397  CL126 HCT 116 C167(0.82); C140(0.87); C270(0.89); C376(0.89)  LDD0714  [13]
 LDCM0398  CL127 HCT 116 C140(0.92); C376(1.00); C34(1.02); C380(1.03)  LDD0715  [13]
 LDCM0399  CL128 HCT 116 C167(0.51); C140(0.57); C376(0.70); C380(0.75)  LDD0716  [13]
 LDCM0400  CL13 HCT 116 C245(0.77); C270(0.86); C167(1.01); C376(1.04)  LDD0717  [13]
 LDCM0401  CL14 HCT 116 C167(0.70); C245(0.74); C140(0.87); C270(0.95)  LDD0718  [13]
 LDCM0402  CL15 HCT 116 C245(0.56); C270(0.74); C140(0.76); C167(0.83)  LDD0719  [13]
 LDCM0403  CL16 HCT 116 C140(0.72); C380(0.88); C376(0.91); C290(0.98)  LDD0720  [13]
 LDCM0404  CL17 HCT 116 C140(0.92); C376(1.00); C845(1.02); C380(1.04)  LDD0721  [13]
 LDCM0405  CL18 HCT 116 C516(1.07); C658(1.16); C650(1.25); C290(1.36)  LDD0722  [13]
 LDCM0406  CL19 HCT 116 C140(0.93); C270(1.07); C34(1.08); C167(1.11)  LDD0723  [13]
 LDCM0407  CL2 HCT 116 C658(0.90); C516(0.93); C34(0.97); C167(0.97)  LDD0724  [13]
 LDCM0408  CL20 HCT 116 C140(0.47); C270(0.61); C167(0.73); C245(0.80)  LDD0725  [13]
 LDCM0409  CL21 HCT 116 C140(0.36); C270(0.42); C167(0.53); C245(0.70)  LDD0726  [13]
 LDCM0410  CL22 HCT 116 C140(0.17); C270(0.22); C167(0.22); C245(0.32)  LDD0727  [13]
 LDCM0411  CL23 HCT 116 C167(0.72); C140(0.78); C270(0.79); C245(0.90)  LDD0728  [13]
 LDCM0412  CL24 HCT 116 C140(0.27); C270(0.38); C167(0.45); C245(0.56)  LDD0729  [13]
 LDCM0413  CL25 HCT 116 C140(0.38); C167(0.54); C245(0.65); C270(0.51)  LDD0730  [13]
 LDCM0414  CL26 HCT 116 C140(0.67); C167(0.82); C245(1.11); C270(0.86)  LDD0731  [13]
 LDCM0415  CL27 HCT 116 C140(0.82); C167(0.81); C245(1.04); C270(0.95)  LDD0732  [13]
 LDCM0416  CL28 HCT 116 C140(0.53); C167(0.76); C245(0.91); C270(0.75)  LDD0733  [13]
 LDCM0417  CL29 HCT 116 C140(0.58); C167(0.72); C245(0.99); C270(0.66)  LDD0734  [13]
 LDCM0418  CL3 HCT 116 C140(0.97); C167(0.93); C245(0.76); C270(0.98)  LDD0735  [13]
 LDCM0419  CL30 HCT 116 C140(0.82); C167(1.11); C245(1.07); C270(0.95)  LDD0736  [13]
 LDCM0420  CL31 HCT 116 C140(0.85); C167(0.79); C245(1.12); C270(0.72)  LDD0737  [13]
 LDCM0421  CL32 HCT 116 C140(2.10); C167(1.30); C245(1.56); C270(0.83)  LDD0738  [13]
 LDCM0422  CL33 HCT 116 C140(0.91); C167(0.86); C245(1.06); C270(0.47)  LDD0739  [13]
 LDCM0423  CL34 HCT 116 C140(0.46); C167(0.62); C245(0.69); C270(0.47)  LDD0740  [13]
 LDCM0424  CL35 HCT 116 C140(0.37); C167(0.63); C245(0.65); C270(0.27)  LDD0741  [13]
 LDCM0425  CL36 HCT 116 C140(0.47); C167(0.59); C245(0.84); C270(0.39)  LDD0742  [13]
 LDCM0426  CL37 HCT 116 C140(0.29); C167(0.53); C245(0.58); C270(0.27)  LDD0743  [13]
 LDCM0428  CL39 HCT 116 C140(0.39); C167(0.65); C245(0.72); C270(0.42)  LDD0745  [13]
 LDCM0429  CL4 HCT 116 C140(1.05); C167(0.89); C245(0.73); C270(0.87)  LDD0746  [13]
 LDCM0430  CL40 HCT 116 C140(0.52); C167(0.62); C245(0.99); C270(0.57)  LDD0747  [13]
 LDCM0431  CL41 HCT 116 C140(0.52); C167(0.81); C245(0.85); C270(0.52)  LDD0748  [13]
 LDCM0432  CL42 HCT 116 C140(0.15); C167(0.52); C245(0.36); C270(0.21)  LDD0749  [13]
 LDCM0433  CL43 HCT 116 C140(0.25); C167(0.55); C245(0.49); C270(0.27)  LDD0750  [13]
 LDCM0434  CL44 HCT 116 C140(0.83); C167(0.70); C245(1.06); C270(0.54)  LDD0751  [13]
 LDCM0435  CL45 HCT 116 C140(0.64); C167(0.59); C245(0.89); C270(0.44)  LDD0752  [13]
 LDCM0436  CL46 HCT 116 C140(1.27); C167(1.11); C245(0.94); C270(1.02)  LDD0753  [13]
 LDCM0437  CL47 HCT 116 C140(1.12); C167(0.97); C245(0.94); C270(0.95)  LDD0754  [13]
 LDCM0438  CL48 HCT 116 C140(1.42); C167(1.08); C245(0.96); C270(0.98)  LDD0755  [13]
 LDCM0439  CL49 HCT 116 C140(1.12); C167(0.96); C245(0.76); C270(1.04)  LDD0756  [13]
 LDCM0440  CL5 HCT 116 C140(1.16); C167(1.07); C245(0.92); C270(1.06)  LDD0757  [13]
 LDCM0441  CL50 HCT 116 C140(1.03); C167(0.96); C245(0.84); C270(0.91)  LDD0758  [13]
 LDCM0442  CL51 HCT 116 C140(1.09); C167(0.95); C245(0.90); C270(1.01)  LDD0759  [13]
 LDCM0443  CL52 HCT 116 C140(1.07); C167(1.01); C245(0.86); C270(0.90)  LDD0760  [13]
 LDCM0444  CL53 HCT 116 C140(1.13); C167(0.88); C245(0.90); C270(0.73)  LDD0761  [13]
 LDCM0445  CL54 HCT 116 C140(1.30); C167(0.97); C245(0.87); C270(0.86)  LDD0762  [13]
 LDCM0446  CL55 HCT 116 C140(1.12); C167(1.04); C245(0.84); C270(0.96)  LDD0763  [13]
 LDCM0447  CL56 HCT 116 C140(0.87); C167(0.83); C245(0.87); C270(0.92)  LDD0764  [13]
 LDCM0448  CL57 HCT 116 C140(0.96); C167(1.02); C245(0.85); C270(0.94)  LDD0765  [13]
 LDCM0449  CL58 HCT 116 C140(1.16); C167(1.11); C245(0.85); C270(0.95)  LDD0766  [13]
 LDCM0450  CL59 HCT 116 C140(0.96); C167(1.01); C245(0.82); C270(0.87)  LDD0767  [13]
 LDCM0451  CL6 HCT 116 C140(1.05); C167(0.88); C245(0.84); C270(1.26)  LDD0768  [13]
 LDCM0452  CL60 HCT 116 C140(1.05); C167(1.01); C245(0.81); C270(0.79)  LDD0769  [13]
 LDCM0453  CL61 HCT 116 C140(0.90); C167(1.64); C245(1.00); C270(1.01)  LDD0770  [13]
 LDCM0454  CL62 HCT 116 C140(0.91); C167(1.03); C245(0.99); C270(0.89)  LDD0771  [13]
 LDCM0455  CL63 HCT 116 C140(0.80); C167(1.00); C245(0.91); C270(0.86)  LDD0772  [13]
 LDCM0456  CL64 HCT 116 C140(0.68); C167(1.29); C245(0.87); C270(0.83)  LDD0773  [13]
 LDCM0457  CL65 HCT 116 C140(0.87); C167(1.28); C245(1.01); C270(0.97)  LDD0774  [13]
 LDCM0458  CL66 HCT 116 C140(0.44); C167(1.19); C245(0.76); C270(0.68)  LDD0775  [13]
 LDCM0459  CL67 HCT 116 C140(0.72); C167(1.56); C245(0.84); C270(0.85)  LDD0776  [13]
 LDCM0460  CL68 HCT 116 C140(0.98); C167(1.49); C245(1.00); C270(0.98)  LDD0777  [13]
 LDCM0461  CL69 HCT 116 C140(1.85); C167(1.42); C245(1.25); C270(1.31)  LDD0778  [13]
 LDCM0462  CL7 HCT 116 C140(1.24); C167(0.93); C245(0.81); C270(0.87)  LDD0779  [13]
 LDCM0463  CL70 HCT 116 C140(1.04); C167(1.39); C245(1.03); C270(0.99)  LDD0780  [13]
 LDCM0464  CL71 HCT 116 C140(0.83); C167(1.09); C245(0.79); C270(0.85)  LDD0781  [13]
 LDCM0465  CL72 HCT 116 C140(0.96); C167(1.06); C245(0.95); C270(0.96)  LDD0782  [13]
 LDCM0466  CL73 HCT 116 C140(1.65); C167(1.29); C245(0.84); C270(0.82)  LDD0783  [13]
 LDCM0467  CL74 HCT 116 C140(1.06); C167(1.22); C245(0.79); C270(0.83)  LDD0784  [13]
 LDCM0469  CL76 HCT 116 C167(1.04); C245(1.15); C270(1.17); C290(1.06)  LDD0786  [13]
 LDCM0470  CL77 HCT 116 C167(0.63); C245(0.56); C270(0.69); C290(1.02)  LDD0787  [13]
 LDCM0471  CL78 HCT 116 C167(0.82); C245(0.88); C270(0.91); C290(0.96)  LDD0788  [13]
 LDCM0472  CL79 HCT 116 C167(0.76); C245(1.04); C270(0.68); C290(0.92)  LDD0789  [13]
 LDCM0473  CL8 HCT 116 C140(0.99); C167(0.64); C245(0.65); C270(0.56)  LDD0790  [13]
 LDCM0474  CL80 HCT 116 C167(1.68); C245(0.88); C270(1.20); C290(1.12)  LDD0791  [13]
 LDCM0475  CL81 HCT 116 C167(0.81); C245(0.99); C270(0.83); C290(1.03)  LDD0792  [13]
 LDCM0476  CL82 HCT 116 C167(0.69); C245(0.91); C270(0.51); C290(0.80)  LDD0793  [13]
 LDCM0477  CL83 HCT 116 C167(0.62); C245(0.74); C270(0.55); C290(0.86)  LDD0794  [13]
 LDCM0478  CL84 HCT 116 C167(0.60); C245(0.77); C270(0.41); C290(0.71)  LDD0795  [13]
 LDCM0479  CL85 HCT 116 C167(0.94); C245(0.86); C270(0.87); C290(1.10)  LDD0796  [13]
 LDCM0480  CL86 HCT 116 C167(0.99); C245(0.75); C270(1.41); C290(1.05)  LDD0797  [13]
 LDCM0481  CL87 HCT 116 C167(0.93); C245(0.83); C270(0.88); C290(0.98)  LDD0798  [13]
 LDCM0482  CL88 HCT 116 C167(0.72); C245(0.87); C270(0.58); C290(0.89)  LDD0799  [13]
 LDCM0483  CL89 HCT 116 C167(0.54); C245(0.81); C270(0.46); C290(0.72)  LDD0800  [13]
 LDCM0484  CL9 HCT 116 C140(0.89); C167(0.85); C245(0.72); C270(0.77)  LDD0801  [13]
 LDCM0485  CL90 HCT 116 C167(0.74); C245(0.53); C270(0.74); C290(0.93)  LDD0802  [13]
 LDCM0486  CL91 HCT 116 C140(0.99); C167(0.71); C245(0.97); C270(1.02)  LDD0803  [13]
 LDCM0487  CL92 HCT 116 C140(0.92); C167(1.13); C245(0.78); C270(0.89)  LDD0804  [13]
 LDCM0488  CL93 HCT 116 C140(1.10); C167(0.90); C245(0.88); C270(1.05)  LDD0805  [13]
 LDCM0489  CL94 HCT 116 C140(0.75); C167(1.14); C245(1.17); C270(1.09)  LDD0806  [13]
 LDCM0490  CL95 HCT 116 C140(0.77); C167(0.92); C245(0.78); C270(0.88)  LDD0807  [13]
 LDCM0491  CL96 HCT 116 C140(0.83); C167(1.21); C245(0.85); C270(0.95)  LDD0808  [13]
 LDCM0492  CL97 HCT 116 C140(1.07); C167(1.27); C245(0.93); C270(0.94)  LDD0809  [13]
 LDCM0493  CL98 HCT 116 C140(0.80); C167(1.08); C245(1.09); C270(1.10)  LDD0810  [13]
 LDCM0494  CL99 HCT 116 C140(0.83); C167(1.23); C245(0.97); C270(1.32)  LDD0811  [13]
 LDCM0634  CY-0357 Hep-G2 C658(50.00); C845(0.84); C34(0.37); C516(0.21)  LDD2228  [22]
 LDCM0495  E2913 HEK-293T C845(0.96); C270(0.89); C516(0.98); C650(0.85)  LDD1698  [37]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C140(7.25); C245(1.44); C650(1.29); C167(1.27)  LDD1702  [35]
 LDCM0175  Ethacrynic acid HeLa C34(0.72)  LDD2210  [9]
 LDCM0625  F8 Ramos C270(0.87); C34(1.57); C658(1.09); C167(0.44)  LDD2187  [38]
 LDCM0572  Fragment10 Ramos C270(0.69); C34(0.64); C658(0.89); C167(0.64)  LDD2189  [38]
 LDCM0573  Fragment11 Ramos C270(5.51); C34(0.58); C658(0.20); C167(1.40)  LDD2190  [38]
 LDCM0574  Fragment12 Ramos C270(0.61); C34(0.55); C658(0.83); C167(0.67)  LDD2191  [38]
 LDCM0575  Fragment13 Ramos C270(0.90); C34(0.89); C658(1.06); C167(0.86)  LDD2192  [38]
 LDCM0576  Fragment14 Ramos C270(1.42); C34(0.66); C658(0.79); C167(0.79)  LDD2193  [38]
 LDCM0579  Fragment20 Ramos C270(0.51); C34(0.45); C658(0.75); C167(0.72)  LDD2194  [38]
 LDCM0580  Fragment21 Ramos C270(0.95); C34(0.86); C658(1.10); C167(0.79)  LDD2195  [38]
 LDCM0582  Fragment23 Ramos C270(0.94); C34(0.98); C658(1.19); C167(1.15)  LDD2196  [38]
 LDCM0578  Fragment27 Ramos C270(0.92); C34(0.76); C658(0.99); C167(1.06)  LDD2197  [38]
 LDCM0586  Fragment28 Ramos C270(0.81); C34(0.65); C658(0.78); C167(0.65)  LDD2198  [38]
 LDCM0588  Fragment30 Ramos C270(1.22); C34(0.87); C658(1.15); C167(0.92)  LDD2199  [38]
 LDCM0589  Fragment31 Ramos C270(1.02); C34(0.73); C658(1.01); C167(1.31)  LDD2200  [38]
 LDCM0590  Fragment32 Ramos C270(0.51); C34(0.59); C658(1.12); C167(0.55)  LDD2201  [38]
 LDCM0468  Fragment33 HCT 116 C140(0.68); C167(1.45); C245(0.87); C270(0.86)  LDD0785  [13]
 LDCM0596  Fragment38 Ramos C270(0.98); C34(0.71); C658(0.89); C167(0.49)  LDD2203  [38]
 LDCM0566  Fragment4 Ramos C270(0.63); C34(0.96); C658(0.82); C167(0.67)  LDD2184  [38]
 LDCM0427  Fragment51 HCT 116 C140(0.19); C167(0.38); C245(0.37); C270(0.21)  LDD0744  [13]
 LDCM0610  Fragment52 Ramos C270(1.17); C34(0.65); C658(0.90); C167(0.72)  LDD2204  [38]
 LDCM0614  Fragment56 Ramos C270(1.36); C34(1.13); C658(1.19); C167(0.66)  LDD2205  [38]
 LDCM0569  Fragment7 Ramos C270(0.63); C34(0.55); C658(0.70); C167(0.52)  LDD2186  [38]
 LDCM0571  Fragment9 Ramos C270(0.62); C34(0.59); C658(0.79); C167(0.58)  LDD2188  [38]
 LDCM0116  HHS-0101 DM93 Y846(0.76); Y677(0.79); Y322(0.80); Y184(0.87)  LDD0264  [11]
 LDCM0117  HHS-0201 DM93 Y846(0.65); Y184(0.80); Y322(0.85); Y677(1.08)  LDD0265  [11]
 LDCM0118  HHS-0301 DM93 Y322(0.66); Y846(0.69); Y184(0.80); Y181(2.07)  LDD0266  [11]
 LDCM0119  HHS-0401 DM93 Y322(0.74); Y846(0.84); Y184(0.91); Y181(1.95)  LDD0267  [11]
 LDCM0120  HHS-0701 DM93 Y846(0.64); Y322(0.77); Y184(0.83); Y677(1.03)  LDD0268  [11]
 LDCM0107  IAA HeLa C310(0.00); C796(0.00); H329(0.00); C245(0.00)  LDD0221  [29]
 LDCM0123  JWB131 DM93 Y184(1.16); Y726(1.13)  LDD0285  [10]
 LDCM0124  JWB142 DM93 Y184(0.61); Y726(0.34)  LDD0286  [10]
 LDCM0125  JWB146 DM93 Y184(1.68); Y726(0.80)  LDD0287  [10]
 LDCM0126  JWB150 DM93 Y184(2.89); Y726(3.64)  LDD0288  [10]
 LDCM0127  JWB152 DM93 Y184(1.74); Y726(2.72)  LDD0289  [10]
 LDCM0128  JWB198 DM93 Y184(1.22); Y726(1.18)  LDD0290  [10]
 LDCM0129  JWB202 DM93 Y184(1.57); Y726(0.49)  LDD0291  [10]
 LDCM0130  JWB211 DM93 Y184(0.89); Y726(0.74)  LDD0292  [10]
 LDCM0022  KB02 HCT 116 C376(5.13); C380(2.29); C290(0.96); C845(1.18)  LDD0080  [13]
 LDCM0023  KB03 HCT 116 C376(20.00); C380(3.07); C290(1.51); C845(0.94)  LDD0081  [13]
 LDCM0024  KB05 HCT 116 C376(4.83); C380(2.48); C290(1.41); C845(1.13)  LDD0082  [13]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C650(0.99); C658(1.00); C845(0.93)  LDD2102  [35]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C796(0.75); C650(0.74); C270(0.75)  LDD2121  [35]
 LDCM0109  NEM HeLa C310(0.00); C167(0.00); H329(0.00); H742(0.00)  LDD0223  [29]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C796(0.69); C650(1.08); C270(0.91); C140(1.13)  LDD2089  [35]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C796(1.03); C650(1.00); C658(1.20); C845(1.09)  LDD2090  [35]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C650(0.98); C658(0.76); C845(0.75)  LDD2092  [35]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C796(0.97); C245(1.22); C650(1.04); C270(1.23)  LDD2093  [35]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C650(1.33); C658(1.01); C845(0.93)  LDD2094  [35]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C796(0.04); C650(0.80); C658(0.07)  LDD2096  [35]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C245(0.71); C650(1.04); C270(0.91); C658(1.40)  LDD2097  [35]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C650(0.69); C658(0.80); C845(0.60)  LDD2098  [35]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C796(1.17); C245(2.55); C650(0.95); C658(0.98)  LDD2099  [35]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C796(0.55); C650(0.49); C658(0.86); C845(1.06)  LDD2100  [35]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C796(0.89); C650(1.13); C270(0.99)  LDD2101  [35]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C796(0.51); C650(0.59); C658(0.76); C845(0.96)  LDD2104  [35]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C650(1.54); C658(1.45); C845(0.70)  LDD2105  [35]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C796(0.89); C650(0.46); C270(0.50); C658(0.88)  LDD2106  [35]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C796(0.84); C650(0.83); C658(1.07); C845(1.03)  LDD2107  [35]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C796(0.46); C650(0.55); C658(0.86); C845(0.94)  LDD2108  [35]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C796(0.73); C650(0.58); C270(0.82); C658(1.09)  LDD2109  [35]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C796(0.50); C650(0.79); C658(1.15); C140(0.72)  LDD2110  [35]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C796(1.00); C245(1.74); C650(1.01); C658(1.12)  LDD2111  [35]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C796(0.56); C650(0.66); C845(1.00); C140(0.68)  LDD2114  [35]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C796(0.62); C270(0.35); C658(0.55); C845(0.86)  LDD2115  [35]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C650(0.78); C658(0.10)  LDD2116  [35]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C796(0.75); C650(0.92); C845(1.07)  LDD2118  [35]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C796(1.73); C245(1.49); C650(2.49); C658(2.64)  LDD2119  [35]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C796(0.84); C650(0.86)  LDD2120  [35]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C650(1.10); C270(0.31); C658(0.15)  LDD2122  [35]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C796(0.96); C245(1.49); C650(0.86); C658(1.05)  LDD2123  [35]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C796(0.80); C650(0.92)  LDD2124  [35]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C796(1.04); C650(0.70); C658(1.14); C845(1.03)  LDD2125  [35]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C796(0.72); C650(0.88)  LDD2126  [35]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C796(1.30); C245(1.71); C650(0.97); C658(1.33)  LDD2127  [35]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C796(0.60); C650(0.95); C658(0.59)  LDD2128  [35]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C245(1.52); C650(0.97); C270(1.40); C658(1.05)  LDD2129  [35]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C796(0.70); C245(0.61); C650(0.85); C270(0.34)  LDD2133  [35]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C796(0.62); C650(0.56); C658(0.56)  LDD2134  [35]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C796(0.90); C245(1.86); C650(1.07); C658(1.02)  LDD2135  [35]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C796(1.32); C245(0.90); C650(1.18); C658(1.30)  LDD2136  [35]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C796(1.15); C245(1.07); C650(0.85); C658(1.28)  LDD2137  [35]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C270(4.59); C650(1.88); C658(1.84); C796(1.29)  LDD1700  [35]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C796(0.90); C245(1.98); C650(0.73); C270(1.24)  LDD2140  [35]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C796(0.83); C245(0.54); C650(0.55); C658(0.77)  LDD2141  [35]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C796(0.69); C650(0.94); C658(0.60)  LDD2143  [35]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C796(2.83); C245(1.73); C650(3.16); C658(2.58)  LDD2144  [35]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C796(0.76); C650(2.42); C270(1.20); C658(9.23)  LDD2145  [35]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C245(1.36); C650(0.81); C270(0.96); C658(1.29)  LDD2146  [35]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C796(1.65); C650(3.03); C658(1.22)  LDD2147  [35]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C796(1.03); C245(0.42); C650(0.56); C658(0.53)  LDD2148  [35]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C796(0.10); C650(0.98); C658(0.15)  LDD2149  [35]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C796(0.53); C245(1.11); C650(0.54); C140(0.60)  LDD2150  [35]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C650(0.99)  LDD2151  [35]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C245(2.49); C650(1.70); C658(1.54); C845(1.00)  LDD2153  [35]
 LDCM0627  NUDT7-COV-1 HEK-293T C658(2.52); C34(2.22)  LDD2206  [39]
 LDCM0628  OTUB2-COV-1 HEK-293T C376(1.39); C658(1.23); C34(0.97)  LDD2207  [39]
 LDCM0131  RA190 MM1.R C290(1.05)  LDD0304  [40]
 LDCM0021  THZ1 HCT 116 C290(1.41); C270(1.23); C845(1.16); C516(1.01)  LDD2173  [13]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Phenethyl Isothiocyanate Small molecular drug DB12695

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
6 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
7 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
8 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
9 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
10 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
11 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
12 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
13 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
14 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
15 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
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Mass spectrometry data entry: PXD028853
17 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
18 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
19 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
20 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
21 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
22 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
23 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
24 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
25 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
26 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
27 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
28 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
29 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
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32 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
33 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
34 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
35 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
36 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
37 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
38 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
39 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
40 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.