Details of the Target

General Information of Target

Target ID LDTP04367
Target Name Hsc70-interacting protein (ST13)
Gene Name ST13
Gene ID 6767
Synonyms
AAG2; FAM10A1; HIP; SNC6; Hsc70-interacting protein; Hip; Aging-associated protein 2; Progesterone receptor-associated p48 protein; Protein FAM10A1; Putative tumor suppressor ST13; Renal carcinoma antigen NY-REN-33; Suppression of tumorigenicity 13 protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDPRKVNELRAFVKMCKQDPSVLHTEEMRFLREWVESMGGKVPPATQKAKSEENTKEEKP
DSKKVEEDLKADEPSSEESDLEIDKEGVIEPDTDAPQEMGDENAEITEEMMDQANDKKVA
AIEALNDGELQKAIDLFTDAIKLNPRLAILYAKRASVFVKLQKPNAAIRDCDRAIEINPD
SAQPYKWRGKAHRLLGHWEEAAHDLALACKLDYDEDASAMLKEVQPRAQKIAEHRRKYER
KREEREIKERIERVKKAREEHERAQREEEARRQSGAQYGSFPGGFPGGMPGNFPGGMPGM
GGGMPGMAGMPGLNEILSDPEVLAAMQDPEVMVAFQDVAQNPANMSKYQSNPKVMNLISK
LSAKFGGQA
Target Bioclass
Other
Family
FAM10 family
Subcellular location
Cytoplasm
Function
One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins.
Uniprot ID
P50502
Ensemble ID
ENST00000216218.8
HGNC ID
HGNC:11343

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 34 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		7.69  LDD0402  [1]
C-Sul
 Probe Info  		2.33  LDD0066  [2]
TH214
 Probe Info  		Y213(20.00)  LDD0258  [3]
TH216
 Probe Info  		Y151(20.00); Y348(11.09)  LDD0259  [3]
STPyne
 Probe Info  		K118(6.97); K14(1.07); K153(5.38); K17(4.39)  LDD0277  [4]
AZ-9
 Probe Info  		D135(0.92); E123(0.96)  LDD2208  [5]
ONAyne
 Probe Info  		K230(0.00); K5(0.00); K364(0.00)  LDD0273  [4]
OPA-S-S-alkyne
 Probe Info  		K230(4.87)  LDD3494  [6]
Probe 1
 Probe Info  		Y185(8.80); Y213(27.98)  LDD3495  [7]
BTD
 Probe Info  		C171(0.14)  LDD2151  [8]
HHS-482
 Probe Info  		Y185(0.84); Y213(0.87)  LDD0285  [9]
HHS-475
 Probe Info  		Y185(0.67); Y151(0.91); Y213(1.04)  LDD0264  [10]
HHS-465
 Probe Info  		Y213(10.00)  LDD2237  [11]
DBIA
 Probe Info  		C209(1.03)  LDD0078  [12]
5E-2FA
 Probe Info  		H261(0.00); H203(0.00); H197(0.00); H24(0.00)  LDD2235  [13]
ATP probe
 Probe Info  		K118(0.00); K153(0.00); K186(0.00); K222(0.00)  LDD0199  [14]
N1
 Probe Info  		C209(0.00); D204(0.00); H203(0.00); K210(0.00)  LDD0245  [15]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [16]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [17]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [18]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [18]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [16]
ATP probe
 Probe Info  		K142(0.00); K153(0.00); K17(0.00)  LDD0035  [19]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [20]
NAIA_4
 Probe Info  		C16(0.00); C209(0.00)  LDD2226  [21]
TFBX
 Probe Info  		N.A.  LDD0027  [20]
IPM
 Probe Info  		N.A.  LDD2156  [22]
NHS
 Probe Info  		K118(0.00); K222(0.00); K153(0.00); K360(0.00)  LDD0010  [23]
SF
 Probe Info  		K50(0.00); K59(0.00); K160(0.00); Y213(0.00)  LDD0028  [24]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [25]
1c-yne
 Probe Info  		K160(0.00); K118(0.00); K222(0.00)  LDD0228  [26]
1d-yne
 Probe Info  		N.A.  LDD0357  [26]
AOyne
 Probe Info  		5.30  LDD0443  [27]
NAIA_5
 Probe Info  		C209(0.00); C16(0.00)  LDD2223  [21]
PAL-AfBPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		5.38  LDD0471  [28]
FFF probe12
 Probe Info  		6.20  LDD0473  [28]
FFF probe13
 Probe Info  		6.90  LDD0475  [28]
FFF probe14
 Probe Info  		6.88  LDD0477  [28]
FFF probe2
 Probe Info  		6.08  LDD0463  [28]
FFF probe3
 Probe Info  		5.03  LDD0464  [28]
JN0003
 Probe Info  		9.51  LDD0469  [28]
STS-2
 Probe Info  		N.A.  LDD0139  [29]
VE-P
 Probe Info  		N.A.  LDD0396  [30]
DA-2
 Probe Info  		N.A.  LDD0070  [31]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C209(0.93)  LDD1507  [32]
 LDCM0215  AC10 HEK-293T C209(0.96)  LDD1508  [32]
 LDCM0226  AC11 HEK-293T C209(0.97)  LDD1509  [32]
 LDCM0237  AC12 HEK-293T C209(0.96)  LDD1510  [32]
 LDCM0259  AC14 HEK-293T C209(0.98)  LDD1512  [32]
 LDCM0270  AC15 HEK-293T C209(0.90)  LDD1513  [32]
 LDCM0276  AC17 HEK-293T C209(0.87)  LDD1515  [32]
 LDCM0277  AC18 HEK-293T C209(1.07)  LDD1516  [32]
 LDCM0278  AC19 HEK-293T C209(0.85)  LDD1517  [32]
 LDCM0279  AC2 HEK-293T C209(1.03)  LDD1518  [32]
 LDCM0280  AC20 HEK-293T C209(0.95)  LDD1519  [32]
 LDCM0281  AC21 HEK-293T C209(0.98)  LDD1520  [32]
 LDCM0282  AC22 HEK-293T C209(0.93)  LDD1521  [32]
 LDCM0283  AC23 HEK-293T C209(0.99)  LDD1522  [32]
 LDCM0284  AC24 HEK-293T C209(1.00)  LDD1523  [32]
 LDCM0285  AC25 HEK-293T C209(0.90)  LDD1524  [32]
 LDCM0286  AC26 HEK-293T C209(0.96)  LDD1525  [32]
 LDCM0287  AC27 HEK-293T C209(0.94)  LDD1526  [32]
 LDCM0288  AC28 HEK-293T C209(0.91)  LDD1527  [32]
 LDCM0289  AC29 HEK-293T C209(1.08)  LDD1528  [32]
 LDCM0290  AC3 HEK-293T C209(0.97)  LDD1529  [32]
 LDCM0291  AC30 HEK-293T C209(0.91)  LDD1530  [32]
 LDCM0292  AC31 HEK-293T C209(0.93)  LDD1531  [32]
 LDCM0293  AC32 HEK-293T C209(0.93)  LDD1532  [32]
 LDCM0294  AC33 HEK-293T C209(0.86)  LDD1533  [32]
 LDCM0295  AC34 HEK-293T C209(0.94)  LDD1534  [32]
 LDCM0296  AC35 HEK-293T C209(1.00)  LDD1535  [32]
 LDCM0297  AC36 HEK-293T C209(0.94)  LDD1536  [32]
 LDCM0298  AC37 HEK-293T C209(1.15)  LDD1537  [32]
 LDCM0299  AC38 HEK-293T C209(1.01)  LDD1538  [32]
 LDCM0300  AC39 HEK-293T C209(0.97)  LDD1539  [32]
 LDCM0301  AC4 HEK-293T C209(1.06)  LDD1540  [32]
 LDCM0302  AC40 HEK-293T C209(0.98)  LDD1541  [32]
 LDCM0303  AC41 HEK-293T C209(0.86)  LDD1542  [32]
 LDCM0304  AC42 HEK-293T C209(0.87)  LDD1543  [32]
 LDCM0305  AC43 HEK-293T C209(0.97)  LDD1544  [32]
 LDCM0306  AC44 HEK-293T C209(1.00)  LDD1545  [32]
 LDCM0307  AC45 HEK-293T C209(1.01)  LDD1546  [32]
 LDCM0308  AC46 HEK-293T C209(0.96)  LDD1547  [32]
 LDCM0309  AC47 HEK-293T C209(0.92)  LDD1548  [32]
 LDCM0310  AC48 HEK-293T C209(1.05)  LDD1549  [32]
 LDCM0311  AC49 HEK-293T C209(0.87)  LDD1550  [32]
 LDCM0312  AC5 HEK-293T C209(1.08)  LDD1551  [32]
 LDCM0313  AC50 HEK-293T C209(0.96)  LDD1552  [32]
 LDCM0314  AC51 HEK-293T C209(1.08)  LDD1553  [32]
 LDCM0315  AC52 HEK-293T C209(1.00)  LDD1554  [32]
 LDCM0316  AC53 HEK-293T C209(1.03)  LDD1555  [32]
 LDCM0317  AC54 HEK-293T C209(0.99)  LDD1556  [32]
 LDCM0318  AC55 HEK-293T C209(0.93)  LDD1557  [32]
 LDCM0319  AC56 HEK-293T C209(1.01)  LDD1558  [32]
 LDCM0320  AC57 HEK-293T C209(0.80)  LDD1559  [32]
 LDCM0321  AC58 HEK-293T C209(0.92)  LDD1560  [32]
 LDCM0322  AC59 HEK-293T C209(1.02)  LDD1561  [32]
 LDCM0323  AC6 HEK-293T C209(1.05)  LDD1562  [32]
 LDCM0324  AC60 HEK-293T C209(0.92)  LDD1563  [32]
 LDCM0325  AC61 HEK-293T C209(0.99)  LDD1564  [32]
 LDCM0326  AC62 HEK-293T C209(0.93)  LDD1565  [32]
 LDCM0327  AC63 HEK-293T C209(0.89)  LDD1566  [32]
 LDCM0328  AC64 HEK-293T C209(1.02)  LDD1567  [32]
 LDCM0334  AC7 HEK-293T C209(1.00)  LDD1568  [32]
 LDCM0345  AC8 HEK-293T C209(0.98)  LDD1569  [32]
 LDCM0248  AKOS034007472 HEK-293T C209(1.08)  LDD1511  [32]
 LDCM0356  AKOS034007680 HEK-293T C209(0.94)  LDD1570  [32]
 LDCM0275  AKOS034007705 HEK-293T C209(0.95)  LDD1514  [32]
 LDCM0156  Aniline NCI-H1299 10.20  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C209(1.03)  LDD0078  [12]
 LDCM0632  CL-Sc Hep-G2 C16(1.01)  LDD2227  [21]
 LDCM0367  CL1 HEK-293T C209(0.97)  LDD1571  [32]
 LDCM0368  CL10 HEK-293T C209(0.81)  LDD1572  [32]
 LDCM0369  CL100 HEK-293T C209(0.97)  LDD1573  [32]
 LDCM0370  CL101 HEK-293T C209(0.96)  LDD1574  [32]
 LDCM0371  CL102 HEK-293T C209(0.89)  LDD1575  [32]
 LDCM0372  CL103 HEK-293T C209(0.96)  LDD1576  [32]
 LDCM0373  CL104 HEK-293T C209(0.95)  LDD1577  [32]
 LDCM0374  CL105 HEK-293T C209(0.94)  LDD1578  [32]
 LDCM0375  CL106 HEK-293T C209(0.94)  LDD1579  [32]
 LDCM0376  CL107 HEK-293T C209(0.98)  LDD1580  [32]
 LDCM0377  CL108 HEK-293T C209(0.92)  LDD1581  [32]
 LDCM0378  CL109 HEK-293T C209(0.89)  LDD1582  [32]
 LDCM0379  CL11 HEK-293T C209(0.88)  LDD1583  [32]
 LDCM0380  CL110 HEK-293T C209(0.85)  LDD1584  [32]
 LDCM0381  CL111 HEK-293T C209(1.02)  LDD1585  [32]
 LDCM0382  CL112 HEK-293T C209(0.89)  LDD1586  [32]
 LDCM0383  CL113 HEK-293T C209(1.03)  LDD1587  [32]
 LDCM0384  CL114 HEK-293T C209(0.83)  LDD1588  [32]
 LDCM0385  CL115 HEK-293T C209(0.99)  LDD1589  [32]
 LDCM0386  CL116 HEK-293T C209(0.99)  LDD1590  [32]
 LDCM0387  CL117 HEK-293T C209(0.98)  LDD1591  [32]
 LDCM0388  CL118 HEK-293T C209(0.88)  LDD1592  [32]
 LDCM0389  CL119 HEK-293T C209(1.01)  LDD1593  [32]
 LDCM0390  CL12 HEK-293T C209(0.95)  LDD1594  [32]
 LDCM0391  CL120 HEK-293T C209(0.93)  LDD1595  [32]
 LDCM0392  CL121 HEK-293T C209(0.96)  LDD1596  [32]
 LDCM0393  CL122 HEK-293T C209(0.91)  LDD1597  [32]
 LDCM0394  CL123 HEK-293T C209(0.87)  LDD1598  [32]
 LDCM0395  CL124 HEK-293T C209(0.96)  LDD1599  [32]
 LDCM0396  CL125 HEK-293T C209(0.97)  LDD1600  [32]
 LDCM0397  CL126 HEK-293T C209(0.90)  LDD1601  [32]
 LDCM0398  CL127 HEK-293T C209(1.04)  LDD1602  [32]
 LDCM0399  CL128 HEK-293T C209(0.95)  LDD1603  [32]
 LDCM0400  CL13 HEK-293T C209(0.94)  LDD1604  [32]
 LDCM0401  CL14 HEK-293T C209(0.94)  LDD1605  [32]
 LDCM0402  CL15 HEK-293T C209(0.88)  LDD1606  [32]
 LDCM0403  CL16 HEK-293T C209(0.92)  LDD1607  [32]
 LDCM0404  CL17 HEK-293T C209(0.75)  LDD1608  [32]
 LDCM0405  CL18 HEK-293T C209(0.93)  LDD1609  [32]
 LDCM0406  CL19 HEK-293T C209(0.93)  LDD1610  [32]
 LDCM0407  CL2 HEK-293T C209(0.93)  LDD1611  [32]
 LDCM0408  CL20 HEK-293T C209(0.97)  LDD1612  [32]
 LDCM0409  CL21 HEK-293T C209(0.95)  LDD1613  [32]
 LDCM0410  CL22 HEK-293T C209(0.93)  LDD1614  [32]
 LDCM0411  CL23 HEK-293T C209(0.90)  LDD1615  [32]
 LDCM0412  CL24 HEK-293T C209(0.99)  LDD1616  [32]
 LDCM0413  CL25 HEK-293T C209(0.94)  LDD1617  [32]
 LDCM0414  CL26 HEK-293T C209(0.98)  LDD1618  [32]
 LDCM0415  CL27 HEK-293T C209(0.95)  LDD1619  [32]
 LDCM0416  CL28 HEK-293T C209(0.98)  LDD1620  [32]
 LDCM0417  CL29 HEK-293T C209(1.01)  LDD1621  [32]
 LDCM0418  CL3 HEK-293T C209(0.96)  LDD1622  [32]
 LDCM0419  CL30 HEK-293T C209(1.02)  LDD1623  [32]
 LDCM0420  CL31 HEK-293T C209(1.05)  LDD1624  [32]
 LDCM0421  CL32 HEK-293T C209(0.95)  LDD1625  [32]
 LDCM0422  CL33 HEK-293T C209(0.88)  LDD1626  [32]
 LDCM0423  CL34 HEK-293T C209(0.93)  LDD1627  [32]
 LDCM0424  CL35 HEK-293T C209(0.94)  LDD1628  [32]
 LDCM0425  CL36 HEK-293T C209(0.99)  LDD1629  [32]
 LDCM0426  CL37 HEK-293T C209(0.99)  LDD1630  [32]
 LDCM0428  CL39 HEK-293T C209(0.94)  LDD1632  [32]
 LDCM0429  CL4 HEK-293T C209(1.00)  LDD1633  [32]
 LDCM0430  CL40 HEK-293T C209(1.00)  LDD1634  [32]
 LDCM0431  CL41 HEK-293T C209(0.85)  LDD1635  [32]
 LDCM0432  CL42 HEK-293T C209(1.03)  LDD1636  [32]
 LDCM0433  CL43 HEK-293T C209(1.03)  LDD1637  [32]
 LDCM0434  CL44 HEK-293T C209(0.97)  LDD1638  [32]
 LDCM0435  CL45 HEK-293T C209(0.93)  LDD1639  [32]
 LDCM0436  CL46 HEK-293T C209(0.90)  LDD1640  [32]
 LDCM0437  CL47 HEK-293T C209(0.93)  LDD1641  [32]
 LDCM0438  CL48 HEK-293T C209(0.97)  LDD1642  [32]
 LDCM0439  CL49 HEK-293T C209(1.03)  LDD1643  [32]
 LDCM0440  CL5 HEK-293T C209(0.93)  LDD1644  [32]
 LDCM0441  CL50 HEK-293T C209(0.98)  LDD1645  [32]
 LDCM0443  CL52 HEK-293T C209(1.10)  LDD1646  [32]
 LDCM0444  CL53 HEK-293T C209(0.79)  LDD1647  [32]
 LDCM0445  CL54 HEK-293T C209(0.82)  LDD1648  [32]
 LDCM0446  CL55 HEK-293T C209(0.99)  LDD1649  [32]
 LDCM0447  CL56 HEK-293T C209(0.98)  LDD1650  [32]
 LDCM0448  CL57 HEK-293T C209(0.92)  LDD1651  [32]
 LDCM0449  CL58 HEK-293T C209(0.93)  LDD1652  [32]
 LDCM0450  CL59 HEK-293T C209(0.92)  LDD1653  [32]
 LDCM0451  CL6 HEK-293T C209(0.89)  LDD1654  [32]
 LDCM0452  CL60 HEK-293T C209(0.99)  LDD1655  [32]
 LDCM0453  CL61 HEK-293T C209(1.00)  LDD1656  [32]
 LDCM0454  CL62 HEK-293T C209(0.94)  LDD1657  [32]
 LDCM0455  CL63 HEK-293T C209(1.08)  LDD1658  [32]
 LDCM0456  CL64 HEK-293T C209(0.96)  LDD1659  [32]
 LDCM0457  CL65 HEK-293T C209(0.89)  LDD1660  [32]
 LDCM0458  CL66 HEK-293T C209(0.96)  LDD1661  [32]
 LDCM0459  CL67 HEK-293T C209(0.99)  LDD1662  [32]
 LDCM0460  CL68 HEK-293T C209(0.91)  LDD1663  [32]
 LDCM0461  CL69 HEK-293T C209(1.04)  LDD1664  [32]
 LDCM0462  CL7 HEK-293T C209(1.02)  LDD1665  [32]
 LDCM0463  CL70 HEK-293T C209(0.94)  LDD1666  [32]
 LDCM0464  CL71 HEK-293T C209(0.90)  LDD1667  [32]
 LDCM0465  CL72 HEK-293T C209(0.96)  LDD1668  [32]
 LDCM0466  CL73 HEK-293T C209(1.00)  LDD1669  [32]
 LDCM0467  CL74 HEK-293T C209(0.98)  LDD1670  [32]
 LDCM0469  CL76 HEK-293T C209(1.03)  LDD1672  [32]
 LDCM0470  CL77 HEK-293T C209(0.79)  LDD1673  [32]
 LDCM0471  CL78 HEK-293T C209(1.00)  LDD1674  [32]
 LDCM0472  CL79 HEK-293T C209(1.00)  LDD1675  [32]
 LDCM0473  CL8 HEK-293T C209(0.73)  LDD1676  [32]
 LDCM0474  CL80 HEK-293T C209(1.06)  LDD1677  [32]
 LDCM0475  CL81 HEK-293T C209(1.09)  LDD1678  [32]
 LDCM0476  CL82 HEK-293T C209(0.96)  LDD1679  [32]
 LDCM0477  CL83 HEK-293T C209(0.94)  LDD1680  [32]
 LDCM0478  CL84 HEK-293T C209(0.97)  LDD1681  [32]
 LDCM0479  CL85 HEK-293T C209(0.98)  LDD1682  [32]
 LDCM0480  CL86 HEK-293T C209(0.96)  LDD1683  [32]
 LDCM0481  CL87 HEK-293T C209(0.93)  LDD1684  [32]
 LDCM0482  CL88 HEK-293T C209(0.94)  LDD1685  [32]
 LDCM0483  CL89 HEK-293T C209(0.84)  LDD1686  [32]
 LDCM0484  CL9 HEK-293T C209(0.97)  LDD1687  [32]
 LDCM0485  CL90 HEK-293T C209(0.79)  LDD1688  [32]
 LDCM0486  CL91 HEK-293T C209(1.06)  LDD1689  [32]
 LDCM0487  CL92 HEK-293T C209(0.91)  LDD1690  [32]
 LDCM0488  CL93 HEK-293T C209(1.00)  LDD1691  [32]
 LDCM0489  CL94 HEK-293T C209(0.90)  LDD1692  [32]
 LDCM0490  CL95 HEK-293T C209(0.74)  LDD1693  [32]
 LDCM0491  CL96 HEK-293T C209(0.94)  LDD1694  [32]
 LDCM0492  CL97 HEK-293T C209(1.01)  LDD1695  [32]
 LDCM0493  CL98 HEK-293T C209(0.95)  LDD1696  [32]
 LDCM0494  CL99 HEK-293T C209(1.02)  LDD1697  [32]
 LDCM0495  E2913 HEK-293T C209(1.00)  LDD1698  [32]
 LDCM0625  F8 Ramos C171(1.24)  LDD2187  [33]
 LDCM0572  Fragment10 Ramos C171(0.69)  LDD2189  [33]
 LDCM0574  Fragment12 Ramos C171(0.56)  LDD2191  [33]
 LDCM0575  Fragment13 Ramos C171(0.95)  LDD2192  [33]
 LDCM0576  Fragment14 Ramos C171(0.77)  LDD2193  [33]
 LDCM0579  Fragment20 Ramos C171(0.50)  LDD2194  [33]
 LDCM0580  Fragment21 Ramos C171(0.75)  LDD2195  [33]
 LDCM0582  Fragment23 Ramos C171(1.49)  LDD2196  [33]
 LDCM0578  Fragment27 Ramos C171(1.09)  LDD2197  [33]
 LDCM0586  Fragment28 Ramos C171(0.40)  LDD2198  [33]
 LDCM0588  Fragment30 Ramos C171(1.29)  LDD2199  [33]
 LDCM0589  Fragment31 Ramos C171(1.39)  LDD2200  [33]
 LDCM0590  Fragment32 Ramos C171(0.90)  LDD2201  [33]
 LDCM0468  Fragment33 HEK-293T C209(0.94)  LDD1671  [32]
 LDCM0596  Fragment38 Ramos C171(2.05)  LDD2203  [33]
 LDCM0566  Fragment4 Ramos C171(0.80)  LDD2184  [33]
 LDCM0427  Fragment51 HEK-293T C209(0.94)  LDD1631  [32]
 LDCM0610  Fragment52 Ramos C171(1.40)  LDD2204  [33]
 LDCM0614  Fragment56 Ramos C171(1.42)  LDD2205  [33]
 LDCM0569  Fragment7 Ramos C171(0.69)  LDD2186  [33]
 LDCM0571  Fragment9 Ramos C171(0.46)  LDD2188  [33]
 LDCM0116  HHS-0101 DM93 Y185(0.67); Y151(0.91); Y213(1.04)  LDD0264  [10]
 LDCM0117  HHS-0201 DM93 Y185(0.50); Y151(1.03); Y213(8.33)  LDD0265  [10]
 LDCM0118  HHS-0301 DM93 Y185(0.39); Y151(1.03); Y213(1.71)  LDD0266  [10]
 LDCM0119  HHS-0401 DM93 Y185(0.44); Y213(0.87)  LDD0267  [10]
 LDCM0120  HHS-0701 DM93 Y213(0.96); Y151(0.97)  LDD0268  [10]
 LDCM0123  JWB131 DM93 Y185(0.84); Y213(0.87)  LDD0285  [9]
 LDCM0124  JWB142 DM93 Y151(0.98); Y185(0.64); Y213(1.34)  LDD0286  [9]
 LDCM0125  JWB146 DM93 Y185(0.75); Y213(0.88)  LDD0287  [9]
 LDCM0126  JWB150 DM93 Y151(16.08); Y185(4.20); Y213(2.87)  LDD0288  [9]
 LDCM0127  JWB152 DM93 Y151(9.67); Y185(1.31); Y213(1.78)  LDD0289  [9]
 LDCM0128  JWB198 DM93 Y151(0.07); Y185(0.65); Y213(1.83)  LDD0290  [9]
 LDCM0129  JWB202 DM93 Y151(1.28); Y185(0.96); Y213(0.93)  LDD0291  [9]
 LDCM0130  JWB211 DM93 Y185(0.76); Y213(0.72)  LDD0292  [9]
 LDCM0022  KB02 HCT 116 C209(1.17)  LDD0080  [12]
 LDCM0023  KB03 HCT 116 C209(1.36)  LDD0081  [12]
 LDCM0024  KB05 HCT 116 C209(1.32)  LDD0082  [12]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C171(0.14)  LDD2151  [8]
 LDCM0627  NUDT7-COV-1 HEK-293T C16(0.94)  LDD2206  [34]
 LDCM0628  OTUB2-COV-1 HEK-293T C16(1.02)  LDD2207  [34]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nitric oxide synthase 3 (NOS3) NOS family P29474
Presenilin-1 (PSEN1) Peptidase A22A family P49768
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Apolipoprotein E (APOE) Apolipoprotein A1/A4/E family P02649
Huntingtin (HTT) Huntingtin family P42858

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
6 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
7 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
8 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
9 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
10 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
11 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
12 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
13 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
14 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
15 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
16 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
17 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
18 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
19 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
20 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
21 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
22 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
23 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
24 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
25 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
26 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
27 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
28 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
29 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
30 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
31 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
32 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
33 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
34 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.