Details of the Target

General Information of Target

Target ID LDTP02697
Target Name cAMP-dependent protein kinase type II-alpha regulatory subunit (PRKAR2A)
Gene Name PRKAR2A
Gene ID 5576
Synonyms
PKR2; PRKAR2; cAMP-dependent protein kinase type II-alpha regulatory subunit
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSHIQIPPGLTELLQGYTVEVLRQQPPDLVEFAVEYFTRLREARAPASVLPAATPRQSLG
HPPPEPGPDRVADAKGDSESEEDEDLEVPVPSRFNRRVSVCAETYNPDEEEEDTDPRVIH
PKTDEQRCRLQEACKDILLFKNLDQEQLSQVLDAMFERIVKADEHVIDQGDDGDNFYVIE
RGTYDILVTKDNQTRSVGQYDNRGSFGELALMYNTPRAATIVATSEGSLWGLDRVTFRRI
IVKNNAKKRKMFESFIESVPLLKSLEVSERMKIVDVIGEKIYKDGERIITQGEKADSFYI
IESGEVSILIRSRTKSNKDGGNQEVEIARCHKGQYFGELALVTNKPRAASAYAVGDVKCL
VMDVQAFERLLGPCMDIMKRNISHYEEQLVKMFGSSVDLGNLGQ
Target Bioclass
Other
Family
CAMP-dependent kinase regulatory chain family
Subcellular location
Cytoplasm
Function
Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.
Uniprot ID
P13861
Ensemble ID
ENST00000265563.13
HGNC ID
HGNC:9391
ChEMBL ID
CHEMBL2221

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HEC1 SNV: p.V100F DBIA    Probe Info 
Ishikawa (Heraklio) 02 ER SNV: p.M1? DBIA    Probe Info 
MELHO SNV: p.P55Q DBIA    Probe Info 
SW480 SNV: p.Q193P .
SW756 SNV: p.S228C DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 25 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
TH211
 Probe Info  		Y335(11.32); Y385(10.91)  LDD0257  [2]
TH216
 Probe Info  		Y385(5.26)  LDD0259  [2]
STPyne
 Probe Info  		K243(2.61); K272(4.41); K345(4.21); K379(7.27)  LDD0277  [3]
BTD
 Probe Info  		C128(8.55)  LDD1699  [4]
Probe 1
 Probe Info  		Y177(9.65); Y200(14.90); Y352(112.70)  LDD3495  [5]
AHL-Pu-1
 Probe Info  		C101(6.78)  LDD0168  [6]
HHS-482
 Probe Info  		Y385(0.69)  LDD0285  [7]
DBIA
 Probe Info  		C101(1.27)  LDD0531  [8]
5E-2FA
 Probe Info  		H384(0.00); H61(0.00)  LDD2235  [9]
ATP probe
 Probe Info  		N.A.  LDD0199  [10]
4-Iodoacetamidophenylacetylene
 Probe Info  		C374(0.00); C359(0.00)  LDD0038  [11]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [12]
Lodoacetamide azide
 Probe Info  		C359(0.00); C374(0.00)  LDD0037  [11]
NAIA_4
 Probe Info  		C101(0.00); C134(0.00); C374(0.00)  LDD2226  [13]
IPM
 Probe Info  		N.A.  LDD0005  [14]
NHS
 Probe Info  		K345(0.00); K190(0.00)  LDD0010  [14]
TFBX
 Probe Info  		N.A.  LDD0148  [15]
Phosphinate-6
 Probe Info  		C374(0.00); C101(0.00)  LDD0018  [16]
Acrolein
 Probe Info  		C101(0.00); H384(0.00); C374(0.00); C134(0.00)  LDD0217  [17]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [17]
Methacrolein
 Probe Info  		C101(0.00); C134(0.00)  LDD0218  [17]
W1
 Probe Info  		N.A.  LDD0236  [18]
AOyne
 Probe Info  		15.00  LDD0443  [19]
NAIA_5
 Probe Info  		C330(0.00); C374(0.00); C134(0.00)  LDD2223  [13]
PAL-AfBPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C158
 Probe Info  		9.25  LDD1838  [20]
FFF probe12
 Probe Info  		5.45  LDD0473  [21]
FFF probe13
 Probe Info  		5.38  LDD0475  [21]
FFF probe3
 Probe Info  		7.44  LDD0465  [21]
JN0003
 Probe Info  		20.00  LDD0469  [21]
VE-P
 Probe Info  		N.A.  LDD0396  [22]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C128(0.68)  LDD2142  [4]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C128(0.97)  LDD2112  [4]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C134(1.28); C128(1.02); C374(1.18)  LDD2117  [4]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C128(1.38)  LDD2152  [4]
 LDCM0025  4SU-RNA HEK-293T C101(6.78)  LDD0168  [6]
 LDCM0026  4SU-RNA+native RNA HEK-293T C134(2.61)  LDD0169  [6]
 LDCM0214  AC1 HCT 116 C101(1.27)  LDD0531  [8]
 LDCM0215  AC10 HCT 116 C101(0.73); C359(1.02)  LDD0532  [8]
 LDCM0216  AC100 HCT 116 C101(0.63)  LDD0533  [8]
 LDCM0217  AC101 HCT 116 C101(1.27)  LDD0534  [8]
 LDCM0218  AC102 HCT 116 C101(0.78)  LDD0535  [8]
 LDCM0219  AC103 HCT 116 C101(1.24)  LDD0536  [8]
 LDCM0220  AC104 HCT 116 C101(0.73)  LDD0537  [8]
 LDCM0221  AC105 HCT 116 C101(1.25)  LDD0538  [8]
 LDCM0222  AC106 HCT 116 C101(1.17)  LDD0539  [8]
 LDCM0223  AC107 HCT 116 C101(0.70)  LDD0540  [8]
 LDCM0224  AC108 HCT 116 C101(1.43)  LDD0541  [8]
 LDCM0225  AC109 HCT 116 C101(0.80)  LDD0542  [8]
 LDCM0226  AC11 HCT 116 C101(1.30); C359(0.82)  LDD0543  [8]
 LDCM0227  AC110 HCT 116 C101(1.10)  LDD0544  [8]
 LDCM0228  AC111 HCT 116 C101(1.84)  LDD0545  [8]
 LDCM0229  AC112 HCT 116 C101(0.66)  LDD0546  [8]
 LDCM0230  AC113 HCT 116 C101(0.87); C374(1.36)  LDD0547  [8]
 LDCM0231  AC114 HCT 116 C101(1.01); C374(1.30)  LDD0548  [8]
 LDCM0232  AC115 HCT 116 C101(1.04); C374(1.31)  LDD0549  [8]
 LDCM0233  AC116 HCT 116 C101(1.02); C374(0.93)  LDD0550  [8]
 LDCM0234  AC117 HCT 116 C101(1.03); C374(0.94)  LDD0551  [8]
 LDCM0235  AC118 HCT 116 C101(0.90); C374(0.95)  LDD0552  [8]
 LDCM0236  AC119 HCT 116 C101(1.54); C374(1.00)  LDD0553  [8]
 LDCM0237  AC12 HCT 116 C101(1.00); C359(0.95)  LDD0554  [8]
 LDCM0238  AC120 HCT 116 C101(0.92); C374(1.19)  LDD0555  [8]
 LDCM0239  AC121 HCT 116 C101(0.80); C374(1.08)  LDD0556  [8]
 LDCM0240  AC122 HCT 116 C101(0.88); C374(1.10)  LDD0557  [8]
 LDCM0241  AC123 HCT 116 C101(1.13); C374(1.03)  LDD0558  [8]
 LDCM0242  AC124 HCT 116 C101(0.96); C374(1.01)  LDD0559  [8]
 LDCM0243  AC125 HCT 116 C101(1.04); C374(1.14)  LDD0560  [8]
 LDCM0244  AC126 HCT 116 C101(1.17); C374(1.25)  LDD0561  [8]
 LDCM0245  AC127 HCT 116 C101(1.13); C374(1.19)  LDD0562  [8]
 LDCM0246  AC128 HEK-293T C101(0.94); C359(1.06)  LDD0844  [8]
 LDCM0247  AC129 HEK-293T C101(1.00); C359(1.08)  LDD0845  [8]
 LDCM0249  AC130 HEK-293T C101(0.92); C359(1.15)  LDD0847  [8]
 LDCM0250  AC131 HEK-293T C101(0.79); C359(1.15)  LDD0848  [8]
 LDCM0251  AC132 HEK-293T C101(1.15); C359(1.20)  LDD0849  [8]
 LDCM0252  AC133 HEK-293T C101(0.90); C359(1.23)  LDD0850  [8]
 LDCM0253  AC134 HEK-293T C101(0.82); C359(1.09)  LDD0851  [8]
 LDCM0254  AC135 HEK-293T C101(0.87); C359(1.11)  LDD0852  [8]
 LDCM0255  AC136 HEK-293T C101(1.20); C359(1.38)  LDD0853  [8]
 LDCM0256  AC137 HEK-293T C101(1.10); C359(1.06)  LDD0854  [8]
 LDCM0257  AC138 HEK-293T C101(0.98); C359(1.09)  LDD0855  [8]
 LDCM0258  AC139 HEK-293T C101(1.14); C359(1.07)  LDD0856  [8]
 LDCM0259  AC14 HCT 116 C101(0.81); C359(1.04)  LDD0576  [8]
 LDCM0260  AC140 HEK-293T C101(0.97); C359(1.17)  LDD0858  [8]
 LDCM0261  AC141 HEK-293T C101(0.94); C359(1.13)  LDD0859  [8]
 LDCM0262  AC142 HEK-293T C101(1.06); C359(0.97)  LDD0860  [8]
 LDCM0263  AC143 HCT 116 C374(0.82); C101(1.30)  LDD0580  [8]
 LDCM0264  AC144 HCT 116 C374(1.03); C101(1.43)  LDD0581  [8]
 LDCM0265  AC145 HCT 116 C374(1.00); C101(1.15)  LDD0582  [8]
 LDCM0266  AC146 HCT 116 C101(1.11); C374(1.19)  LDD0583  [8]
 LDCM0267  AC147 HCT 116 C374(0.99); C101(1.46)  LDD0584  [8]
 LDCM0268  AC148 HCT 116 C374(1.12); C101(1.45)  LDD0585  [8]
 LDCM0269  AC149 HCT 116 C374(1.18); C101(1.47)  LDD0586  [8]
 LDCM0270  AC15 HCT 116 C101(0.89); C359(0.89)  LDD0587  [8]
 LDCM0271  AC150 HCT 116 C374(1.00); C101(1.22)  LDD0588  [8]
 LDCM0272  AC151 HCT 116 C374(1.13); C101(1.31)  LDD0589  [8]
 LDCM0273  AC152 HCT 116 C374(1.14); C101(1.17)  LDD0590  [8]
 LDCM0274  AC153 HCT 116 C374(1.61); C101(1.61)  LDD0591  [8]
 LDCM0621  AC154 HCT 116 C101(1.51); C374(1.12)  LDD2158  [8]
 LDCM0622  AC155 HCT 116 C101(1.21); C374(1.30)  LDD2159  [8]
 LDCM0623  AC156 HCT 116 C101(1.74); C374(1.08)  LDD2160  [8]
 LDCM0624  AC157 HCT 116 C101(1.00); C374(1.21)  LDD2161  [8]
 LDCM0276  AC17 HCT 116 C359(0.49); C101(0.97)  LDD0593  [8]
 LDCM0277  AC18 HCT 116 C359(0.50); C101(1.26)  LDD0594  [8]
 LDCM0278  AC19 HCT 116 C359(0.79); C101(1.05)  LDD0595  [8]
 LDCM0279  AC2 HCT 116 C101(1.50)  LDD0596  [8]
 LDCM0280  AC20 HCT 116 C101(0.80); C359(0.98)  LDD0597  [8]
 LDCM0281  AC21 HCT 116 C101(0.91); C359(1.25)  LDD0598  [8]
 LDCM0282  AC22 HCT 116 C359(0.66); C101(0.77)  LDD0599  [8]
 LDCM0283  AC23 HCT 116 C101(0.74); C359(0.85)  LDD0600  [8]
 LDCM0284  AC24 HCT 116 C101(0.87); C359(0.89)  LDD0601  [8]
 LDCM0285  AC25 HCT 116 C101(0.67); C359(0.68); C374(0.72)  LDD0602  [8]
 LDCM0286  AC26 HCT 116 C374(0.54); C359(0.81); C101(0.95)  LDD0603  [8]
 LDCM0287  AC27 HCT 116 C374(0.49); C359(0.75); C101(1.46)  LDD0604  [8]
 LDCM0288  AC28 HCT 116 C374(0.49); C359(0.65); C101(1.15)  LDD0605  [8]
 LDCM0289  AC29 HCT 116 C374(0.57); C359(0.82); C101(1.04)  LDD0606  [8]
 LDCM0290  AC3 HCT 116 C101(1.63)  LDD0607  [8]
 LDCM0291  AC30 HCT 116 C374(0.46); C359(0.71); C101(0.89)  LDD0608  [8]
 LDCM0292  AC31 HCT 116 C374(0.50); C359(0.72); C101(1.19)  LDD0609  [8]
 LDCM0293  AC32 HCT 116 C374(0.41); C359(0.60); C101(1.56)  LDD0610  [8]
 LDCM0294  AC33 HCT 116 C374(0.41); C359(0.63); C101(1.20)  LDD0611  [8]
 LDCM0295  AC34 HCT 116 C374(0.39); C359(0.56); C101(1.47)  LDD0612  [8]
 LDCM0296  AC35 HCT 116 C359(0.78); C374(0.98); C101(1.29)  LDD0613  [8]
 LDCM0297  AC36 HCT 116 C374(0.91); C101(1.16); C359(1.24)  LDD0614  [8]
 LDCM0298  AC37 HCT 116 C374(0.89); C101(0.98); C359(1.17)  LDD0615  [8]
 LDCM0299  AC38 HCT 116 C359(0.92); C101(0.98); C374(1.13)  LDD0616  [8]
 LDCM0300  AC39 HCT 116 C359(0.93); C374(1.17); C101(1.34)  LDD0617  [8]
 LDCM0301  AC4 HCT 116 C101(1.43)  LDD0618  [8]
 LDCM0302  AC40 HCT 116 C359(1.03); C374(1.03); C101(1.30)  LDD0619  [8]
 LDCM0303  AC41 HCT 116 C374(0.71); C359(0.86); C101(1.37)  LDD0620  [8]
 LDCM0304  AC42 HCT 116 C374(0.84); C359(0.95); C101(1.12)  LDD0621  [8]
 LDCM0305  AC43 HCT 116 C374(0.83); C359(0.99); C101(1.07)  LDD0622  [8]
 LDCM0306  AC44 HCT 116 C374(0.88); C359(0.96); C101(1.51)  LDD0623  [8]
 LDCM0307  AC45 HCT 116 C374(0.85); C359(0.98); C101(1.43)  LDD0624  [8]
 LDCM0308  AC46 HCT 116 C101(0.81); C359(0.81)  LDD0625  [8]
 LDCM0309  AC47 HCT 116 C359(0.83); C101(1.10)  LDD0626  [8]
 LDCM0310  AC48 HCT 116 C359(0.88); C101(0.97)  LDD0627  [8]
 LDCM0311  AC49 HCT 116 C359(0.80); C101(1.66)  LDD0628  [8]
 LDCM0312  AC5 HCT 116 C101(1.64)  LDD0629  [8]
 LDCM0313  AC50 HCT 116 C359(0.81); C101(1.65)  LDD0630  [8]
 LDCM0314  AC51 HCT 116 C101(0.68); C359(1.30)  LDD0631  [8]
 LDCM0315  AC52 HCT 116 C359(0.78); C101(0.82)  LDD0632  [8]
 LDCM0316  AC53 HCT 116 C359(0.88); C101(1.42)  LDD0633  [8]
 LDCM0317  AC54 HCT 116 C359(0.76); C101(1.32)  LDD0634  [8]
 LDCM0318  AC55 HCT 116 C359(0.88); C101(1.95)  LDD0635  [8]
 LDCM0319  AC56 HCT 116 C359(0.96); C101(2.10)  LDD0636  [8]
 LDCM0320  AC57 HCT 116 C359(0.70); C101(2.04)  LDD0637  [8]
 LDCM0321  AC58 HCT 116 C359(0.78); C101(2.59)  LDD0638  [8]
 LDCM0322  AC59 HCT 116 C359(0.82); C101(2.94)  LDD0639  [8]
 LDCM0323  AC6 HCT 116 C101(0.82); C359(1.01)  LDD0640  [8]
 LDCM0324  AC60 HCT 116 C359(0.73); C101(2.16)  LDD0641  [8]
 LDCM0325  AC61 HCT 116 C359(0.79); C101(1.73)  LDD0642  [8]
 LDCM0326  AC62 HCT 116 C359(0.76); C101(2.46)  LDD0643  [8]
 LDCM0327  AC63 HCT 116 C359(0.69); C101(1.78)  LDD0644  [8]
 LDCM0328  AC64 HCT 116 C359(0.75); C101(3.38)  LDD0645  [8]
 LDCM0329  AC65 HCT 116 C359(0.91); C101(1.97)  LDD0646  [8]
 LDCM0330  AC66 HCT 116 C359(0.77); C101(1.93)  LDD0647  [8]
 LDCM0331  AC67 HCT 116 C359(0.67); C101(1.98)  LDD0648  [8]
 LDCM0332  AC68 HCT 116 C101(0.79); C359(0.89)  LDD0649  [8]
 LDCM0333  AC69 HCT 116 C359(0.79); C101(1.15)  LDD0650  [8]
 LDCM0334  AC7 HCT 116 C101(0.93); C359(1.16)  LDD0651  [8]
 LDCM0335  AC70 HCT 116 C359(0.67); C101(0.71)  LDD0652  [8]
 LDCM0336  AC71 HCT 116 C359(1.04); C101(1.09)  LDD0653  [8]
 LDCM0337  AC72 HCT 116 C359(0.77); C101(1.44)  LDD0654  [8]
 LDCM0338  AC73 HCT 116 C359(0.81); C101(1.16)  LDD0655  [8]
 LDCM0339  AC74 HCT 116 C359(0.87); C101(1.10)  LDD0656  [8]
 LDCM0340  AC75 HCT 116 C359(0.96); C101(1.41)  LDD0657  [8]
 LDCM0341  AC76 HCT 116 C359(0.62); C101(1.12)  LDD0658  [8]
 LDCM0342  AC77 HCT 116 C359(0.79); C101(1.08)  LDD0659  [8]
 LDCM0343  AC78 HCT 116 C101(1.03); C359(1.08)  LDD0660  [8]
 LDCM0344  AC79 HCT 116 C359(0.77); C101(1.33)  LDD0661  [8]
 LDCM0345  AC8 HCT 116 C359(0.77); C101(1.15)  LDD0662  [8]
 LDCM0346  AC80 HCT 116 C359(0.79); C101(1.09)  LDD0663  [8]
 LDCM0347  AC81 HCT 116 C101(1.01); C359(1.18)  LDD0664  [8]
 LDCM0348  AC82 HCT 116 C359(0.84); C101(1.13)  LDD0665  [8]
 LDCM0349  AC83 HCT 116 C101(1.46)  LDD0666  [8]
 LDCM0350  AC84 HCT 116 C101(1.38)  LDD0667  [8]
 LDCM0351  AC85 HCT 116 C101(1.74)  LDD0668  [8]
 LDCM0352  AC86 HCT 116 C101(1.59)  LDD0669  [8]
 LDCM0353  AC87 HCT 116 C101(1.12)  LDD0670  [8]
 LDCM0354  AC88 HCT 116 C101(1.58)  LDD0671  [8]
 LDCM0355  AC89 HCT 116 C101(1.41)  LDD0672  [8]
 LDCM0357  AC90 HCT 116 C101(1.39)  LDD0674  [8]
 LDCM0358  AC91 HCT 116 C101(1.34)  LDD0675  [8]
 LDCM0359  AC92 HCT 116 C101(1.66)  LDD0676  [8]
 LDCM0360  AC93 HCT 116 C101(1.16)  LDD0677  [8]
 LDCM0361  AC94 HCT 116 C101(0.95)  LDD0678  [8]
 LDCM0362  AC95 HCT 116 C101(1.41)  LDD0679  [8]
 LDCM0363  AC96 HCT 116 C101(0.99)  LDD0680  [8]
 LDCM0364  AC97 HCT 116 C101(1.24)  LDD0681  [8]
 LDCM0365  AC98 HCT 116 C101(1.44)  LDD0682  [8]
 LDCM0366  AC99 HCT 116 C101(1.19)  LDD0683  [8]
 LDCM0520  AKOS000195272 MDA-MB-231 C134(0.74); C128(0.61)  LDD2113  [4]
 LDCM0248  AKOS034007472 HCT 116 C101(0.88); C359(1.20)  LDD0565  [8]
 LDCM0356  AKOS034007680 HCT 116 C101(0.97); C359(1.14)  LDD0673  [8]
 LDCM0275  AKOS034007705 HCT 116 C359(0.80); C101(0.97)  LDD0592  [8]
 LDCM0156  Aniline NCI-H1299 12.15  LDD0403  [1]
 LDCM0498  BS-3668 MDA-MB-231 C134(0.70)  LDD2091  [4]
 LDCM0630  CCW28-3 231MFP C101(2.05)  LDD2214  [23]
 LDCM0108  Chloroacetamide HeLa C101(0.00); C374(0.00)  LDD0222  [17]
 LDCM0367  CL1 HEK-293T C101(1.04); C359(1.02); C374(1.04)  LDD0965  [8]
 LDCM0368  CL10 HEK-293T C101(1.70); C359(0.86); C374(1.70)  LDD0966  [8]
 LDCM0369  CL100 HCT 116 C101(1.72)  LDD0686  [8]
 LDCM0370  CL101 HCT 116 C101(0.69); C359(0.90)  LDD0687  [8]
 LDCM0371  CL102 HCT 116 C101(0.77); C359(0.88)  LDD0688  [8]
 LDCM0372  CL103 HCT 116 C101(0.94); C359(1.11)  LDD0689  [8]
 LDCM0373  CL104 HCT 116 C101(0.88); C359(0.95)  LDD0690  [8]
 LDCM0374  CL105 HCT 116 C359(0.81); C101(1.08)  LDD0691  [8]
 LDCM0375  CL106 HCT 116 C359(0.72); C101(1.46)  LDD0692  [8]
 LDCM0376  CL107 HCT 116 C359(1.10); C101(1.27)  LDD0693  [8]
 LDCM0377  CL108 HCT 116 C359(0.77); C101(1.28)  LDD0694  [8]
 LDCM0378  CL109 HCT 116 C359(0.73); C101(1.10)  LDD0695  [8]
 LDCM0379  CL11 HEK-293T C101(1.58); C359(1.23); C374(1.58)  LDD0977  [8]
 LDCM0380  CL110 HCT 116 C359(0.66); C101(1.45)  LDD0697  [8]
 LDCM0381  CL111 HCT 116 C359(0.67); C101(1.17)  LDD0698  [8]
 LDCM0382  CL112 HCT 116 C359(0.66); C101(0.74); C374(0.87)  LDD0699  [8]
 LDCM0383  CL113 HCT 116 C374(0.44); C359(0.61); C101(1.32)  LDD0700  [8]
 LDCM0384  CL114 HCT 116 C374(0.62); C359(0.89); C101(0.94)  LDD0701  [8]
 LDCM0385  CL115 HCT 116 C374(0.56); C359(0.74); C101(1.19)  LDD0702  [8]
 LDCM0386  CL116 HCT 116 C374(0.60); C359(0.75); C101(1.06)  LDD0703  [8]
 LDCM0387  CL117 HCT 116 C359(1.03); C374(1.21); C101(1.52)  LDD0704  [8]
 LDCM0388  CL118 HCT 116 C359(0.96); C374(1.01); C101(1.31)  LDD0705  [8]
 LDCM0389  CL119 HCT 116 C359(0.82); C374(0.94); C101(1.38)  LDD0706  [8]
 LDCM0390  CL12 HEK-293T C101(1.35); C359(1.42); C374(1.35)  LDD0988  [8]
 LDCM0391  CL120 HCT 116 C374(0.78); C359(0.96); C101(1.02)  LDD0708  [8]
 LDCM0392  CL121 HCT 116 C359(0.70); C101(0.94)  LDD0709  [8]
 LDCM0393  CL122 HCT 116 C359(0.84); C101(1.07)  LDD0710  [8]
 LDCM0394  CL123 HCT 116 C359(0.77); C101(1.21)  LDD0711  [8]
 LDCM0395  CL124 HCT 116 C359(0.77); C101(1.36)  LDD0712  [8]
 LDCM0396  CL125 HCT 116 C359(0.97); C101(1.37)  LDD0713  [8]
 LDCM0397  CL126 HCT 116 C359(0.75); C101(2.48)  LDD0714  [8]
 LDCM0398  CL127 HCT 116 C359(1.02); C101(2.09)  LDD0715  [8]
 LDCM0399  CL128 HCT 116 C359(0.73); C101(3.22)  LDD0716  [8]
 LDCM0400  CL13 HEK-293T C101(1.40); C359(1.37); C374(1.40)  LDD0998  [8]
 LDCM0401  CL14 HEK-293T C101(1.61); C359(1.17); C374(1.61)  LDD0999  [8]
 LDCM0402  CL15 HEK-293T C101(2.70); C359(1.05); C374(2.70)  LDD1000  [8]
 LDCM0403  CL16 HCT 116 C374(1.09); C101(1.53)  LDD0720  [8]
 LDCM0404  CL17 HCT 116 C101(0.94)  LDD0721  [8]
 LDCM0405  CL18 HCT 116 C101(1.28)  LDD0722  [8]
 LDCM0406  CL19 HCT 116 C101(1.13)  LDD0723  [8]
 LDCM0407  CL2 HEK-293T C101(1.02); C359(1.04); C374(1.02)  LDD1005  [8]
 LDCM0408  CL20 HCT 116 C101(1.27)  LDD0725  [8]
 LDCM0409  CL21 HCT 116 C101(1.05)  LDD0726  [8]
 LDCM0410  CL22 HCT 116 C101(1.46)  LDD0727  [8]
 LDCM0411  CL23 HCT 116 C101(1.17)  LDD0728  [8]
 LDCM0412  CL24 HCT 116 C101(1.37)  LDD0729  [8]
 LDCM0413  CL25 HCT 116 C101(1.45)  LDD0730  [8]
 LDCM0414  CL26 HCT 116 C101(1.33)  LDD0731  [8]
 LDCM0415  CL27 HCT 116 C101(1.14)  LDD0732  [8]
 LDCM0416  CL28 HCT 116 C101(1.82)  LDD0733  [8]
 LDCM0417  CL29 HCT 116 C101(1.31)  LDD0734  [8]
 LDCM0418  CL3 HEK-293T C101(1.00); C359(1.38); C374(1.00)  LDD1016  [8]
 LDCM0419  CL30 HCT 116 C101(1.21)  LDD0736  [8]
 LDCM0420  CL31 HCT 116 C359(0.91)  LDD0737  [8]
 LDCM0421  CL32 HCT 116 C359(0.92); C374(0.94)  LDD0738  [8]
 LDCM0422  CL33 HCT 116 C359(0.86); C374(0.97)  LDD0739  [8]
 LDCM0423  CL34 HCT 116 C359(0.69); C374(1.10)  LDD0740  [8]
 LDCM0424  CL35 HCT 116 C359(0.85); C374(1.25)  LDD0741  [8]
 LDCM0425  CL36 HCT 116 C359(0.91); C374(1.25)  LDD0742  [8]
 LDCM0426  CL37 HCT 116 C359(0.78); C374(1.25)  LDD0743  [8]
 LDCM0428  CL39 HCT 116 C359(0.80); C374(1.14)  LDD0745  [8]
 LDCM0429  CL4 HEK-293T C101(0.95); C359(0.99); C374(0.95)  LDD1027  [8]
 LDCM0430  CL40 HCT 116 C359(0.73); C374(1.11)  LDD0747  [8]
 LDCM0431  CL41 HCT 116 C359(0.81); C374(1.00)  LDD0748  [8]
 LDCM0432  CL42 HCT 116 C359(0.83); C374(1.26)  LDD0749  [8]
 LDCM0433  CL43 HCT 116 C359(0.79); C374(1.10)  LDD0750  [8]
 LDCM0434  CL44 HCT 116 C359(0.83); C374(1.23)  LDD0751  [8]
 LDCM0435  CL45 HCT 116 C359(0.92); C374(1.19)  LDD0752  [8]
 LDCM0436  CL46 HEK-293T C101(1.16); C374(1.04)  LDD1034  [8]
 LDCM0437  CL47 HEK-293T C101(1.46); C374(1.18)  LDD1035  [8]
 LDCM0438  CL48 HEK-293T C101(1.44); C374(0.99)  LDD1036  [8]
 LDCM0439  CL49 HEK-293T C101(1.09); C374(1.13)  LDD1037  [8]
 LDCM0440  CL5 HEK-293T C101(1.08); C359(1.16); C374(1.08)  LDD1038  [8]
 LDCM0441  CL50 HEK-293T C101(1.25); C374(1.55)  LDD1039  [8]
 LDCM0442  CL51 HEK-293T C101(1.42); C374(1.53)  LDD1040  [8]
 LDCM0443  CL52 HEK-293T C101(1.15); C374(0.94)  LDD1041  [8]
 LDCM0444  CL53 HEK-293T C101(1.09); C374(1.21)  LDD1042  [8]
 LDCM0445  CL54 HEK-293T C101(1.22); C374(1.37)  LDD1043  [8]
 LDCM0446  CL55 HEK-293T C101(0.92); C374(1.05)  LDD1044  [8]
 LDCM0447  CL56 HEK-293T C101(1.01); C374(1.02)  LDD1045  [8]
 LDCM0448  CL57 HEK-293T C101(1.19); C374(1.28)  LDD1046  [8]
 LDCM0449  CL58 HEK-293T C101(1.46); C374(1.35)  LDD1047  [8]
 LDCM0450  CL59 HEK-293T C101(1.24); C374(1.20)  LDD1048  [8]
 LDCM0451  CL6 HEK-293T C101(1.00); C359(1.24); C374(1.00)  LDD1049  [8]
 LDCM0452  CL60 HEK-293T C101(1.60); C374(1.38)  LDD1050  [8]
 LDCM0453  CL61 HEK-293T C101(1.13); C374(1.13)  LDD1051  [8]
 LDCM0454  CL62 HEK-293T C101(0.97); C374(0.97)  LDD1052  [8]
 LDCM0455  CL63 HEK-293T C101(1.00); C374(1.00)  LDD1053  [8]
 LDCM0456  CL64 HEK-293T C101(0.93); C374(0.93)  LDD1054  [8]
 LDCM0457  CL65 HEK-293T C101(0.84); C374(0.84)  LDD1055  [8]
 LDCM0458  CL66 HEK-293T C101(1.04); C374(1.04)  LDD1056  [8]
 LDCM0459  CL67 HEK-293T C101(0.98); C374(0.98)  LDD1057  [8]
 LDCM0460  CL68 HEK-293T C101(1.19); C374(1.19)  LDD1058  [8]
 LDCM0461  CL69 HEK-293T C101(1.00); C374(1.00)  LDD1059  [8]
 LDCM0462  CL7 HEK-293T C101(2.32); C359(1.24); C374(2.32)  LDD1060  [8]
 LDCM0463  CL70 HEK-293T C101(1.02); C374(1.02)  LDD1061  [8]
 LDCM0464  CL71 HEK-293T C101(1.25); C374(1.25)  LDD1062  [8]
 LDCM0465  CL72 HEK-293T C101(0.86); C374(0.86)  LDD1063  [8]
 LDCM0466  CL73 HEK-293T C101(1.19); C374(1.19)  LDD1064  [8]
 LDCM0467  CL74 HEK-293T C101(1.50); C374(1.50)  LDD1065  [8]
 LDCM0469  CL76 HCT 116 C374(0.69)  LDD0786  [8]
 LDCM0470  CL77 HCT 116 C374(0.67)  LDD0787  [8]
 LDCM0471  CL78 HCT 116 C374(0.57)  LDD0788  [8]
 LDCM0472  CL79 HCT 116 C374(0.47)  LDD0789  [8]
 LDCM0473  CL8 HEK-293T C101(1.82); C359(1.87)  LDD1071  [8]
 LDCM0474  CL80 HCT 116 C374(0.79)  LDD0791  [8]
 LDCM0475  CL81 HCT 116 C374(0.58)  LDD0792  [8]
 LDCM0476  CL82 HCT 116 C374(0.45)  LDD0793  [8]
 LDCM0477  CL83 HCT 116 C374(0.47)  LDD0794  [8]
 LDCM0478  CL84 HCT 116 C374(0.44)  LDD0795  [8]
 LDCM0479  CL85 HCT 116 C374(0.53)  LDD0796  [8]
 LDCM0480  CL86 HCT 116 C374(0.69)  LDD0797  [8]
 LDCM0481  CL87 HCT 116 C374(0.54)  LDD0798  [8]
 LDCM0482  CL88 HCT 116 C374(0.47)  LDD0799  [8]
 LDCM0483  CL89 HCT 116 C374(0.49)  LDD0800  [8]
 LDCM0484  CL9 HEK-293T C101(1.18); C359(1.49)  LDD1082  [8]
 LDCM0485  CL90 HCT 116 C374(1.10)  LDD0802  [8]
 LDCM0486  CL91 HCT 116 C101(0.94)  LDD0803  [8]
 LDCM0487  CL92 HCT 116 C101(0.96)  LDD0804  [8]
 LDCM0488  CL93 HCT 116 C101(1.38)  LDD0805  [8]
 LDCM0489  CL94 HCT 116 C101(1.40)  LDD0806  [8]
 LDCM0490  CL95 HCT 116 C101(1.09)  LDD0807  [8]
 LDCM0491  CL96 HCT 116 C101(1.37)  LDD0808  [8]
 LDCM0492  CL97 HCT 116 C101(1.46)  LDD0809  [8]
 LDCM0493  CL98 HCT 116 C101(1.27)  LDD0810  [8]
 LDCM0494  CL99 HCT 116 C101(1.32)  LDD0811  [8]
 LDCM0495  E2913 HEK-293T C101(0.88); C374(0.95); C359(1.09)  LDD1698  [24]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C374(3.22); C134(1.85)  LDD1702  [4]
 LDCM0625  F8 Ramos C374(1.16); C101(1.71); C359(0.63)  LDD2187  [25]
 LDCM0572  Fragment10 Ramos C374(1.20); C101(2.26); C359(1.26)  LDD2189  [25]
 LDCM0573  Fragment11 Ramos C374(1.10); C101(0.95); C359(0.30)  LDD2190  [25]
 LDCM0574  Fragment12 Ramos C374(1.12); C101(0.96); C359(3.46)  LDD2191  [25]
 LDCM0575  Fragment13 Ramos C374(1.05); C101(0.91); C359(0.86)  LDD2192  [25]
 LDCM0576  Fragment14 Ramos C374(1.05); C101(1.71); C359(1.76)  LDD2193  [25]
 LDCM0579  Fragment20 Ramos C374(1.60); C101(1.51); C359(2.79)  LDD2194  [25]
 LDCM0580  Fragment21 Ramos C374(0.79); C101(1.34); C359(0.94)  LDD2195  [25]
 LDCM0582  Fragment23 Ramos C374(1.54); C101(1.79); C359(0.98)  LDD2196  [25]
 LDCM0578  Fragment27 Ramos C374(0.97); C101(1.13); C359(0.81)  LDD2197  [25]
 LDCM0586  Fragment28 Ramos C374(1.12); C101(1.02); C359(0.29)  LDD2198  [25]
 LDCM0588  Fragment30 Ramos C374(1.25); C101(1.15); C359(1.38)  LDD2199  [25]
 LDCM0589  Fragment31 Ramos C374(1.47); C101(1.62); C359(0.92)  LDD2200  [25]
 LDCM0590  Fragment32 Ramos C374(0.88); C101(2.81); C359(1.62)  LDD2201  [25]
 LDCM0468  Fragment33 HEK-293T C101(1.53); C374(1.53)  LDD1066  [8]
 LDCM0596  Fragment38 Ramos C374(1.04); C101(1.20); C359(1.41)  LDD2203  [25]
 LDCM0566  Fragment4 Ramos C374(1.77); C101(1.67); C359(0.78)  LDD2184  [25]
 LDCM0427  Fragment51 HCT 116 C359(0.72); C374(1.24)  LDD0744  [8]
 LDCM0610  Fragment52 Ramos C374(1.16); C101(1.05); C359(0.85)  LDD2204  [25]
 LDCM0614  Fragment56 Ramos C374(1.26); C101(1.43); C359(0.52)  LDD2205  [25]
 LDCM0569  Fragment7 Ramos C374(1.43); C101(1.55); C359(1.24)  LDD2186  [25]
 LDCM0571  Fragment9 Ramos C374(1.56); C101(2.44); C359(2.09)  LDD2188  [25]
 LDCM0107  IAA HeLa C374(0.00); H384(0.00)  LDD0221  [17]
 LDCM0123  JWB131 DM93 Y385(0.69)  LDD0285  [7]
 LDCM0124  JWB142 DM93 Y385(1.11)  LDD0286  [7]
 LDCM0126  JWB150 DM93 Y385(1.72)  LDD0288  [7]
 LDCM0127  JWB152 DM93 Y385(1.30)  LDD0289  [7]
 LDCM0128  JWB198 DM93 Y385(0.18)  LDD0290  [7]
 LDCM0129  JWB202 DM93 Y385(1.65)  LDD0291  [7]
 LDCM0130  JWB211 DM93 Y385(0.05)  LDD0292  [7]
 LDCM0022  KB02 HEK-293T C101(1.02); C374(1.03); C359(1.09)  LDD1492  [24]
 LDCM0023  KB03 HEK-293T C101(1.15); C374(1.01); C359(0.90)  LDD1497  [24]
 LDCM0024  KB05 COLO792 C374(2.36)  LDD3310  [26]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C128(0.91)  LDD2102  [4]
 LDCM0109  NEM HeLa H384(0.00); H165(0.00)  LDD0223  [17]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C128(0.51)  LDD2089  [4]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C128(0.99)  LDD2090  [4]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C128(0.64)  LDD2093  [4]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C128(0.89)  LDD2094  [4]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C134(0.88); C128(0.41)  LDD2096  [4]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C128(0.93)  LDD2098  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C128(0.58)  LDD2099  [4]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C134(0.58); C128(1.15)  LDD2100  [4]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C128(0.66)  LDD2101  [4]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C128(1.27)  LDD2104  [4]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C128(1.57)  LDD2105  [4]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C128(0.90)  LDD2106  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C134(1.24); C128(0.87); C374(1.91)  LDD2107  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C128(0.61); C374(0.96)  LDD2109  [4]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C128(2.61)  LDD2110  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C374(1.69)  LDD2111  [4]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C128(0.90)  LDD2114  [4]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C128(0.53)  LDD2116  [4]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C128(0.57)  LDD2118  [4]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C128(2.75)  LDD2119  [4]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C128(1.00)  LDD2120  [4]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C134(0.63); C128(0.52)  LDD2122  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C134(0.63); C128(0.55); C374(1.19)  LDD2123  [4]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C134(0.91); C128(0.50)  LDD2124  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C128(0.61); C374(1.27)  LDD2125  [4]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C128(0.45)  LDD2126  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C134(1.25); C128(0.86); C374(1.46)  LDD2127  [4]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C128(0.85)  LDD2128  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C134(0.78); C128(0.47)  LDD2129  [4]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C134(0.46); C128(1.48)  LDD2134  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C128(0.38)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C128(0.79)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C134(1.04); C128(0.81); C374(0.99)  LDD2137  [4]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C128(0.91)  LDD1700  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C134(0.73); C128(0.52); C374(1.40)  LDD2140  [4]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C128(0.76)  LDD2141  [4]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C128(1.25)  LDD2143  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C128(4.26)  LDD2144  [4]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C128(10.75)  LDD2145  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C128(0.57); C374(0.99)  LDD2146  [4]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C134(0.53); C128(1.06)  LDD2148  [4]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C128(0.50)  LDD2149  [4]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C128(0.42)  LDD2150  [4]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C128(0.83)  LDD2151  [4]
 LDCM0131  RA190 MM1.R C101(2.18)  LDD0304  [27]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
A-kinase anchor protein 5 (AKAP5) . P24588
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
A-kinase anchor protein 3 (AKAP3) AKAP110 family O75969
A-kinase anchor protein 8 (AKAP8) AKAP95 family O43823
Ligand-dependent nuclear receptor-interacting factor 1 (LRIF1) LRIF1 family Q5T3J3
A-kinase anchor protein 1, mitochondrial (AKAP1) . Q92667
A-kinase anchor protein 14 (AKAP14) . Q86UN6

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Gem-231 . DB05798

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
10 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
11 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
12 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
13 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
14 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
15 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
16 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
17 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
18 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
19 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
20 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
21 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
22 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
23 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
24 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
25 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
26 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
27 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.