Details of the Target

General Information of Target

Target ID LDTP12085
Target Name Damage-control phosphatase ARMT1 (ARMT1)
Gene Name ARMT1
Gene ID 79624
Synonyms
C6orf211; Damage-control phosphatase ARMT1; EC 3.1.3.-; Acidic residue methyltransferase 1; Protein-glutamate O-methyltransferase; EC 2.1.1.-; Sugar phosphate phosphatase ARMT1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MESKPSRIPRRISVQPSSSLSARMMSGSRGSSLNDTYHSRDSSFRLDSEYQSTSASASAS
PFQSAWYSESEITQGARSRSQNQQRDHDSKRPKLSCTNCTTSAGRNVGNGLNTLSDSSWR
HSQVPRSSSMVLGSFGTDLMRERRDLERRTDSSISNLMDYSHRSGDFTTSSYVQDRVPSY
SQGARPKENSMSTLQLNTSSTNHQLPSEHQTILSSRDSRNSLRSNFSSRESESSRSNTQP
GFSYSSSRDEAPIISNSERVVSSQRPFQESSDNEGRRTTRRLLSRIASSMSSTFFSRRSS
QDSLNTRSLNSENSYVSPRILTASQSRSNVPSASEVPDNRASEASQGFRFLRRRWGLSSL
SHNHSSESDSENFNQESEGRNTGPWLSSSLRNRCTPLFSRRRREGRDESSRIPTSDTSSR
SHIFRRESNEVVHLEAQNDPLGAAANRPQASAASSSATTGGSTSDSAQGGRNTGISGILP
GSLFRFAVPPALGSNLTDNVMITVDIIPSGWNSADGKSDKTKSAPSRDPERLQKIKESLL
LEDSEEEEGDLCRICQMAAASSSNLLIEPCKCTGSLQYVHQDCMKKWLQAKINSGSSLEA
VTTCELCKEKLELNLEDFDIHELHRAHANEQAEYEFISSGLYLVVLLHLCEQSFSDMMGN
TNEPSTRVRFINLARTLQAHMEDLETSEDDSEEDGDHNRTFDIA
Target Bioclass
Enzyme
Family
Damage-control phosphatase family, Sugar phosphate phosphatase III subfamily
Function
Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism. Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Possibly methylates PCNA, suggesting it is involved in the DNA damage response.
Uniprot ID
Q9H993
Ensemble ID
ENST00000367294.4
HGNC ID
HGNC:17872

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K40(10.00); K64(7.18); K73(5.03)  LDD0277  [1]
DBIA
 Probe Info  		C343(0.74)  LDD3332  [2]
HHS-475
 Probe Info  		Y94(3.20)  LDD0264  [3]
ATP probe
 Probe Info  		K40(0.00); K46(0.00)  LDD0199  [4]
1d-yne
 Probe Info  		N.A.  LDD0358  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		C315(0.00); C159(0.00); C398(0.00); C343(0.00)  LDD0038  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [7]
IPIAA_H
 Probe Info  		C159(0.00); C315(0.00)  LDD0030  [8]
IPIAA_L
 Probe Info  		C315(0.00); C159(0.00)  LDD0031  [8]
Lodoacetamide azide
 Probe Info  		C315(0.00); C159(0.00); C118(0.00); C343(0.00)  LDD0037  [6]
IPM
 Probe Info  		C315(0.00); C194(0.00)  LDD2156  [9]
NHS
 Probe Info  		N.A.  LDD0010  [10]
SF
 Probe Info  		N.A.  LDD0028  [11]
NAIA_5
 Probe Info  		C315(0.00); C159(0.00); C398(0.00); C118(0.00)  LDD2223  [12]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe12
 Probe Info  		6.59  LDD0473  [13]
FFF probe13
 Probe Info  		12.23  LDD0475  [13]
FFF probe14
 Probe Info  		20.00  LDD0477  [13]
FFF probe3
 Probe Info  		13.74  LDD0465  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C315(0.99); C398(1.10); C159(1.01); C194(0.88)  LDD1507  [14]
 LDCM0215  AC10 HEK-293T C315(1.05); C398(1.02); C159(1.00); C194(0.91)  LDD1508  [14]
 LDCM0226  AC11 HEK-293T C315(1.08); C398(0.97); C159(0.93); C194(1.06)  LDD1509  [14]
 LDCM0237  AC12 HEK-293T C315(1.07); C398(0.97); C159(1.20); C194(0.84)  LDD1510  [14]
 LDCM0259  AC14 HEK-293T C315(1.10); C398(0.98); C159(1.05); C343(0.97)  LDD1512  [14]
 LDCM0263  AC143 PaTu 8988t C315(0.69)  LDD1142  [15]
 LDCM0264  AC144 PaTu 8988t C315(1.27)  LDD1143  [15]
 LDCM0265  AC145 PaTu 8988t C315(0.84)  LDD1144  [15]
 LDCM0266  AC146 PaTu 8988t C315(1.01)  LDD1145  [15]
 LDCM0267  AC147 PaTu 8988t C315(0.86)  LDD1146  [15]
 LDCM0268  AC148 PaTu 8988t C315(0.53)  LDD1147  [15]
 LDCM0269  AC149 PaTu 8988t C315(0.35)  LDD1148  [15]
 LDCM0270  AC15 HEK-293T C315(1.06); C398(0.92); C159(1.10); C194(0.82)  LDD1513  [14]
 LDCM0271  AC150 PaTu 8988t C315(0.63)  LDD1150  [15]
 LDCM0272  AC151 PaTu 8988t C315(0.28)  LDD1151  [15]
 LDCM0273  AC152 PaTu 8988t C315(0.36)  LDD1152  [15]
 LDCM0274  AC153 PaTu 8988t C315(0.23)  LDD1153  [15]
 LDCM0621  AC154 PaTu 8988t C315(0.29)  LDD2166  [15]
 LDCM0622  AC155 PaTu 8988t C315(0.48)  LDD2167  [15]
 LDCM0623  AC156 PaTu 8988t C315(0.64)  LDD2168  [15]
 LDCM0624  AC157 PaTu 8988t C315(0.73)  LDD2169  [15]
 LDCM0276  AC17 PaTu 8988t C315(0.93)  LDD1155  [15]
 LDCM0277  AC18 PaTu 8988t C315(0.32)  LDD1156  [15]
 LDCM0278  AC19 PaTu 8988t C315(0.61)  LDD1157  [15]
 LDCM0279  AC2 HEK-293T C315(1.00); C398(1.24); C159(1.04); C194(0.83)  LDD1518  [14]
 LDCM0280  AC20 PaTu 8988t C315(0.38)  LDD1159  [15]
 LDCM0281  AC21 PaTu 8988t C315(0.24)  LDD1160  [15]
 LDCM0282  AC22 PaTu 8988t C315(0.26)  LDD1161  [15]
 LDCM0283  AC23 PaTu 8988t C315(0.22)  LDD1162  [15]
 LDCM0284  AC24 PaTu 8988t C315(2.12)  LDD1163  [15]
 LDCM0285  AC25 HEK-293T C315(0.96); C398(1.02); C159(0.98); C194(0.82)  LDD1524  [14]
 LDCM0286  AC26 HEK-293T C315(0.99); C398(1.18); C159(1.00); C194(0.81)  LDD1525  [14]
 LDCM0287  AC27 HEK-293T C315(1.06); C398(0.98); C159(0.80); C194(0.93)  LDD1526  [14]
 LDCM0288  AC28 HEK-293T C315(1.15); C398(1.05); C159(1.12); C194(0.90)  LDD1527  [14]
 LDCM0289  AC29 HEK-293T C315(1.03); C398(0.94); C159(1.03); C343(1.07)  LDD1528  [14]
 LDCM0290  AC3 HEK-293T C315(1.04); C398(1.05); C159(0.84); C194(0.95)  LDD1529  [14]
 LDCM0291  AC30 HEK-293T C315(1.03); C398(0.98); C159(1.03); C343(0.99)  LDD1530  [14]
 LDCM0292  AC31 HEK-293T C315(1.01); C398(1.05); C159(0.98); C194(0.81)  LDD1531  [14]
 LDCM0293  AC32 HEK-293T C315(1.02); C398(0.99); C159(0.96); C194(0.86)  LDD1532  [14]
 LDCM0294  AC33 HEK-293T C315(0.92); C398(1.04); C159(1.04); C194(0.83)  LDD1533  [14]
 LDCM0295  AC34 HEK-293T C315(1.01); C398(1.00); C159(1.03); C194(0.89)  LDD1534  [14]
 LDCM0296  AC35 HEK-293T C315(1.05); C398(0.95); C159(0.96); C194(1.01)  LDD1535  [14]
 LDCM0297  AC36 HEK-293T C315(1.03); C398(1.08); C159(1.08); C194(0.80)  LDD1536  [14]
 LDCM0298  AC37 HEK-293T C315(0.95); C398(1.00); C159(0.97); C343(1.12)  LDD1537  [14]
 LDCM0299  AC38 HEK-293T C315(1.12); C398(0.85); C159(1.09); C343(1.04)  LDD1538  [14]
 LDCM0300  AC39 HEK-293T C315(1.00); C398(1.11); C159(1.06); C194(0.95)  LDD1539  [14]
 LDCM0301  AC4 HEK-293T C315(1.01); C398(1.24); C159(1.07); C194(0.84)  LDD1540  [14]
 LDCM0302  AC40 HEK-293T C315(1.04); C398(1.00); C159(0.97); C194(0.92)  LDD1541  [14]
 LDCM0303  AC41 HEK-293T C315(0.98); C398(1.10); C159(1.16); C194(0.99)  LDD1542  [14]
 LDCM0304  AC42 HEK-293T C315(0.95); C398(1.00); C159(1.00); C194(0.79)  LDD1543  [14]
 LDCM0305  AC43 HEK-293T C315(1.04); C398(0.98); C159(0.93); C194(1.00)  LDD1544  [14]
 LDCM0306  AC44 HEK-293T C315(1.13); C398(1.04); C159(1.05); C194(0.87)  LDD1545  [14]
 LDCM0307  AC45 HEK-293T C315(1.07); C398(1.07); C159(0.99); C343(1.02)  LDD1546  [14]
 LDCM0308  AC46 HEK-293T C315(1.02); C398(0.96); C159(1.15); C343(0.98)  LDD1547  [14]
 LDCM0309  AC47 HEK-293T C315(1.03); C398(1.05); C159(1.03); C194(1.19)  LDD1548  [14]
 LDCM0310  AC48 HEK-293T C315(1.08); C398(1.04); C159(1.04); C194(1.07)  LDD1549  [14]
 LDCM0311  AC49 HEK-293T C315(0.98); C398(1.05); C159(1.10); C194(1.00)  LDD1550  [14]
 LDCM0312  AC5 HEK-293T C315(1.03); C398(1.08); C159(1.07); C343(1.16)  LDD1551  [14]
 LDCM0313  AC50 HEK-293T C315(1.03); C398(0.98); C159(0.93); C194(0.89)  LDD1552  [14]
 LDCM0314  AC51 HEK-293T C315(1.04); C398(1.02); C159(0.88); C194(1.02)  LDD1553  [14]
 LDCM0315  AC52 HEK-293T C315(1.05); C398(1.02); C159(1.09); C194(0.84)  LDD1554  [14]
 LDCM0316  AC53 HEK-293T C315(1.03); C398(0.97); C159(1.13); C343(1.06)  LDD1555  [14]
 LDCM0317  AC54 HEK-293T C315(1.06); C398(0.98); C159(1.09); C343(1.20)  LDD1556  [14]
 LDCM0318  AC55 HEK-293T C315(1.10); C398(0.99); C159(1.06); C194(1.03)  LDD1557  [14]
 LDCM0319  AC56 HEK-293T C315(1.06); C398(0.96); C159(1.05); C194(0.96)  LDD1558  [14]
 LDCM0320  AC57 HEK-293T C315(0.92); C398(0.92); C159(1.04); C194(0.91)  LDD1559  [14]
 LDCM0321  AC58 HEK-293T C315(1.03); C398(1.09); C159(1.09); C194(0.87)  LDD1560  [14]
 LDCM0322  AC59 HEK-293T C315(1.04); C398(1.04); C159(0.96); C194(1.11)  LDD1561  [14]
 LDCM0323  AC6 HEK-293T C315(1.17); C398(1.01); C159(1.03); C343(1.03)  LDD1562  [14]
 LDCM0324  AC60 HEK-293T C315(1.05); C398(1.09); C159(1.18); C194(0.85)  LDD1563  [14]
 LDCM0325  AC61 HEK-293T C315(0.98); C398(1.06); C159(0.99); C343(1.01)  LDD1564  [14]
 LDCM0326  AC62 HEK-293T C315(1.09); C398(0.88); C159(0.99); C343(1.08)  LDD1565  [14]
 LDCM0327  AC63 HEK-293T C315(0.98); C398(1.07); C159(1.03); C194(0.87)  LDD1566  [14]
 LDCM0328  AC64 HEK-293T C315(1.05); C398(1.02); C159(1.01); C194(1.00)  LDD1567  [14]
 LDCM0334  AC7 HEK-293T C315(0.98); C398(1.01); C159(1.08); C194(1.12)  LDD1568  [14]
 LDCM0345  AC8 HEK-293T C315(1.03); C398(1.03); C159(0.98); C194(0.90)  LDD1569  [14]
 LDCM0248  AKOS034007472 HEK-293T C315(0.98); C398(0.93); C159(1.03); C343(0.98)  LDD1511  [14]
 LDCM0356  AKOS034007680 HEK-293T C315(1.01); C398(1.03); C159(1.12); C194(0.93)  LDD1570  [14]
 LDCM0275  AKOS034007705 HEK-293T C315(1.10); C398(0.95); C159(0.97); C194(0.97)  LDD1514  [14]
 LDCM0367  CL1 PaTu 8988t C315(1.05)  LDD1246  [15]
 LDCM0368  CL10 PaTu 8988t C315(0.28)  LDD1247  [15]
 LDCM0369  CL100 HEK-293T C315(0.98); C398(1.04); C159(1.03); C194(0.71)  LDD1573  [14]
 LDCM0370  CL101 HEK-293T C315(1.06); C398(0.89); C159(1.06); C194(0.99)  LDD1574  [14]
 LDCM0371  CL102 HEK-293T C315(1.06); C398(0.81); C159(0.95); C194(0.92)  LDD1575  [14]
 LDCM0372  CL103 HEK-293T C315(1.03); C398(0.97); C159(0.97); C194(1.05)  LDD1576  [14]
 LDCM0373  CL104 HEK-293T C315(1.03); C398(1.03); C159(0.93); C194(0.90)  LDD1577  [14]
 LDCM0374  CL105 PaTu 8988t C315(1.19)  LDD1253  [15]
 LDCM0375  CL106 PaTu 8988t C315(1.09)  LDD1254  [15]
 LDCM0376  CL107 PaTu 8988t C315(1.44)  LDD1255  [15]
 LDCM0377  CL108 PaTu 8988t C315(0.76)  LDD1256  [15]
 LDCM0378  CL109 PaTu 8988t C315(0.70)  LDD1257  [15]
 LDCM0379  CL11 PaTu 8988t C315(1.08)  LDD1258  [15]
 LDCM0380  CL110 PaTu 8988t C315(0.66)  LDD1259  [15]
 LDCM0381  CL111 PaTu 8988t C315(0.24)  LDD1260  [15]
 LDCM0382  CL112 HEK-293T C315(0.96); C398(0.99); C159(1.00); C194(0.83)  LDD1586  [14]
 LDCM0383  CL113 HEK-293T C315(1.10); C398(1.03); C159(1.14); C194(1.00)  LDD1587  [14]
 LDCM0384  CL114 HEK-293T C315(1.12); C398(1.13); C159(1.09); C194(0.97)  LDD1588  [14]
 LDCM0385  CL115 HEK-293T C315(1.07); C398(1.10); C159(1.08); C194(1.17)  LDD1589  [14]
 LDCM0386  CL116 HEK-293T C315(0.99); C398(1.08); C159(1.02); C194(0.98)  LDD1590  [14]
 LDCM0387  CL117 HEK-293T C315(1.07); C398(1.09); C159(1.01); C194(1.13)  LDD1591  [14]
 LDCM0388  CL118 HEK-293T C315(1.04); C398(0.99); C159(1.08); C194(1.10)  LDD1592  [14]
 LDCM0389  CL119 HEK-293T C315(0.97); C398(1.09); C159(0.95); C194(1.16)  LDD1593  [14]
 LDCM0390  CL12 PaTu 8988t C315(0.68)  LDD1269  [15]
 LDCM0391  CL120 HEK-293T C315(1.09); C398(1.14); C159(0.98); C194(0.90)  LDD1595  [14]
 LDCM0392  CL121 HEK-293T C315(1.16); C398(0.97); C159(0.99); C194(0.98)  LDD1596  [14]
 LDCM0393  CL122 HEK-293T C315(1.16); C398(1.00); C159(0.86); C194(1.11)  LDD1597  [14]
 LDCM0394  CL123 HEK-293T C315(1.03); C398(1.00); C159(0.96); C194(1.12)  LDD1598  [14]
 LDCM0395  CL124 HEK-293T C315(1.18); C398(1.00); C159(0.93); C194(1.02)  LDD1599  [14]
 LDCM0396  CL125 HEK-293T C315(1.12); C398(1.12); C159(1.13); C194(1.02)  LDD1600  [14]
 LDCM0397  CL126 HEK-293T C315(1.05); C398(1.06); C159(1.22); C194(0.94)  LDD1601  [14]
 LDCM0398  CL127 HEK-293T C315(1.12); C398(1.05); C159(0.96); C194(1.01)  LDD1602  [14]
 LDCM0399  CL128 HEK-293T C315(0.99); C398(1.05); C159(0.98); C194(0.94)  LDD1603  [14]
 LDCM0400  CL13 PaTu 8988t C315(0.33)  LDD1279  [15]
 LDCM0401  CL14 PaTu 8988t C315(0.32)  LDD1280  [15]
 LDCM0402  CL15 PaTu 8988t C315(0.36)  LDD1281  [15]
 LDCM0403  CL16 HEK-293T C315(1.04); C398(1.10); C159(1.19); C194(0.96)  LDD1607  [14]
 LDCM0404  CL17 HEK-293T C315(1.00); C398(0.79); C159(0.95); C194(1.08)  LDD1608  [14]
 LDCM0405  CL18 HEK-293T C315(1.16); C398(0.72); C159(1.05); C194(1.20)  LDD1609  [14]
 LDCM0406  CL19 HEK-293T C315(1.10); C398(0.79); C159(0.96); C194(1.44)  LDD1610  [14]
 LDCM0407  CL2 PaTu 8988t C315(0.82)  LDD1286  [15]
 LDCM0408  CL20 HEK-293T C315(1.17); C398(0.54); C159(1.03); C194(1.66)  LDD1612  [14]
 LDCM0409  CL21 HEK-293T C315(1.11); C398(0.57); C159(1.02); C343(0.93)  LDD1613  [14]
 LDCM0410  CL22 HEK-293T C315(1.20); C398(0.49); C159(1.14); C343(1.06)  LDD1614  [14]
 LDCM0411  CL23 HEK-293T C315(1.19); C398(0.51); C159(1.04); C194(1.74)  LDD1615  [14]
 LDCM0412  CL24 HEK-293T C315(1.12); C398(0.54); C159(1.05); C194(2.04)  LDD1616  [14]
 LDCM0413  CL25 HEK-293T C315(1.19); C398(0.92); C159(0.91); C194(0.98)  LDD1617  [14]
 LDCM0414  CL26 HEK-293T C315(1.18); C398(0.99); C159(1.11); C194(1.07)  LDD1618  [14]
 LDCM0415  CL27 HEK-293T C315(0.93); C398(0.95); C159(1.03); C194(1.19)  LDD1619  [14]
 LDCM0416  CL28 HEK-293T C315(1.03); C398(1.02); C159(1.00); C194(0.97)  LDD1620  [14]
 LDCM0417  CL29 HEK-293T C315(1.07); C398(0.90); C159(1.05); C194(1.04)  LDD1621  [14]
 LDCM0418  CL3 PaTu 8988t C315(1.26)  LDD1297  [15]
 LDCM0419  CL30 HEK-293T C315(1.06); C398(0.78); C159(0.93); C194(1.17)  LDD1623  [14]
 LDCM0420  CL31 HEK-293T C315(1.18); C398(0.73); C159(0.86); C194(1.50)  LDD1624  [14]
 LDCM0421  CL32 HEK-293T C315(1.16); C398(0.63); C159(0.96); C194(1.39)  LDD1625  [14]
 LDCM0422  CL33 HEK-293T C315(1.25); C398(0.56); C159(1.04); C343(0.90)  LDD1626  [14]
 LDCM0423  CL34 HEK-293T C315(1.21); C398(0.46); C159(1.00); C343(1.16)  LDD1627  [14]
 LDCM0424  CL35 HEK-293T C315(1.16); C398(0.45); C159(1.03); C194(1.84)  LDD1628  [14]
 LDCM0425  CL36 HEK-293T C315(1.13); C398(0.53); C159(0.95); C194(2.27)  LDD1629  [14]
 LDCM0426  CL37 HEK-293T C315(1.02); C398(1.11); C159(1.06); C194(1.13)  LDD1630  [14]
 LDCM0428  CL39 HEK-293T C315(0.75); C398(1.04); C159(0.96); C194(1.17)  LDD1632  [14]
 LDCM0429  CL4 PaTu 8988t C315(1.23)  LDD1308  [15]
 LDCM0430  CL40 HEK-293T C315(0.99); C398(0.90); C159(0.97); C194(0.89)  LDD1634  [14]
 LDCM0431  CL41 HEK-293T C315(0.98); C398(0.86); C159(0.99); C194(0.92)  LDD1635  [14]
 LDCM0432  CL42 HEK-293T C315(1.00); C398(0.76); C159(1.03); C194(1.28)  LDD1636  [14]
 LDCM0433  CL43 HEK-293T C315(1.09); C398(0.81); C159(0.89); C194(1.52)  LDD1637  [14]
 LDCM0434  CL44 HEK-293T C315(1.06); C398(0.58); C159(0.90); C194(1.21)  LDD1638  [14]
 LDCM0435  CL45 HEK-293T C315(1.15); C398(0.57); C159(0.96); C343(0.97)  LDD1639  [14]
 LDCM0436  CL46 HEK-293T C315(1.21); C398(0.44); C159(1.11); C343(1.00)  LDD1640  [14]
 LDCM0437  CL47 HEK-293T C315(1.15); C398(0.46); C159(0.98); C194(1.77)  LDD1641  [14]
 LDCM0438  CL48 HEK-293T C315(1.19); C398(0.51); C159(1.03); C194(3.94)  LDD1642  [14]
 LDCM0439  CL49 HEK-293T C315(1.19); C398(1.11); C159(1.16); C194(1.12)  LDD1643  [14]
 LDCM0440  CL5 PaTu 8988t C315(0.35)  LDD1319  [15]
 LDCM0441  CL50 HEK-293T C315(1.02); C398(0.99); C159(1.25); C194(0.99)  LDD1645  [14]
 LDCM0443  CL52 HEK-293T C315(1.04); C398(0.99); C159(1.12); C194(0.92)  LDD1646  [14]
 LDCM0444  CL53 HEK-293T C315(0.95); C398(0.85); C159(1.02); C194(1.01)  LDD1647  [14]
 LDCM0445  CL54 HEK-293T C315(1.02); C398(0.73); C159(0.99); C194(1.19)  LDD1648  [14]
 LDCM0446  CL55 HEK-293T C315(1.08); C398(0.83); C159(0.95); C194(1.59)  LDD1649  [14]
 LDCM0447  CL56 HEK-293T C315(1.18); C398(0.60); C159(0.93); C194(1.30)  LDD1650  [14]
 LDCM0448  CL57 HEK-293T C315(1.08); C398(0.54); C159(0.88); C343(0.91)  LDD1651  [14]
 LDCM0449  CL58 HEK-293T C315(1.24); C398(0.46); C159(1.07); C343(1.12)  LDD1652  [14]
 LDCM0450  CL59 HEK-293T C315(1.23); C398(0.48); C159(1.04); C194(1.93)  LDD1653  [14]
 LDCM0451  CL6 PaTu 8988t C315(0.27)  LDD1330  [15]
 LDCM0452  CL60 HEK-293T C315(1.13); C398(0.52); C159(1.04); C194(2.35)  LDD1655  [14]
 LDCM0453  CL61 PaTu 8988t C315(1.61)  LDD1332  [15]
 LDCM0454  CL62 PaTu 8988t C315(1.41)  LDD1333  [15]
 LDCM0455  CL63 PaTu 8988t C315(1.67)  LDD1334  [15]
 LDCM0456  CL64 PaTu 8988t C315(1.40)  LDD1335  [15]
 LDCM0457  CL65 PaTu 8988t C315(0.88)  LDD1336  [15]
 LDCM0458  CL66 PaTu 8988t C315(0.69)  LDD1337  [15]
 LDCM0459  CL67 PaTu 8988t C315(0.27)  LDD1338  [15]
 LDCM0460  CL68 PaTu 8988t C315(0.33)  LDD1339  [15]
 LDCM0461  CL69 PaTu 8988t C315(0.28)  LDD1340  [15]
 LDCM0462  CL7 PaTu 8988t C315(0.30)  LDD1341  [15]
 LDCM0463  CL70 PaTu 8988t C315(0.30)  LDD1342  [15]
 LDCM0464  CL71 PaTu 8988t C315(2.21)  LDD1343  [15]
 LDCM0465  CL72 PaTu 8988t C315(1.94)  LDD1344  [15]
 LDCM0466  CL73 PaTu 8988t C315(0.27)  LDD1345  [15]
 LDCM0467  CL74 PaTu 8988t C315(1.70)  LDD1346  [15]
 LDCM0469  CL76 PaTu 8988t C315(1.02)  LDD1348  [15]
 LDCM0470  CL77 PaTu 8988t C315(0.88)  LDD1349  [15]
 LDCM0471  CL78 PaTu 8988t C315(0.87)  LDD1350  [15]
 LDCM0472  CL79 PaTu 8988t C315(1.31)  LDD1351  [15]
 LDCM0473  CL8 PaTu 8988t C315(0.73)  LDD1352  [15]
 LDCM0474  CL80 PaTu 8988t C315(1.40)  LDD1353  [15]
 LDCM0475  CL81 PaTu 8988t C315(0.39)  LDD1354  [15]
 LDCM0476  CL82 PaTu 8988t C315(0.76)  LDD1355  [15]
 LDCM0477  CL83 PaTu 8988t C315(0.80)  LDD1356  [15]
 LDCM0478  CL84 PaTu 8988t C315(0.26)  LDD1357  [15]
 LDCM0479  CL85 PaTu 8988t C315(1.09)  LDD1358  [15]
 LDCM0480  CL86 PaTu 8988t C315(1.28)  LDD1359  [15]
 LDCM0481  CL87 PaTu 8988t C315(0.24)  LDD1360  [15]
 LDCM0482  CL88 PaTu 8988t C315(0.35)  LDD1361  [15]
 LDCM0483  CL89 PaTu 8988t C315(0.25)  LDD1362  [15]
 LDCM0484  CL9 PaTu 8988t C315(0.25)  LDD1363  [15]
 LDCM0485  CL90 PaTu 8988t C315(0.24)  LDD1364  [15]
 LDCM0486  CL91 HEK-293T C315(1.11); C398(0.89); C159(0.89); C194(1.51)  LDD1689  [14]
 LDCM0487  CL92 HEK-293T C315(1.13); C398(0.78); C159(1.03); C194(1.07)  LDD1690  [14]
 LDCM0488  CL93 HEK-293T C315(1.14); C398(0.60); C159(1.16); C343(1.07)  LDD1691  [14]
 LDCM0489  CL94 HEK-293T C315(1.11); C398(0.58); C159(1.12); C343(0.99)  LDD1692  [14]
 LDCM0490  CL95 HEK-293T C315(1.16); C398(0.32); C159(1.02); C194(1.18)  LDD1693  [14]
 LDCM0491  CL96 HEK-293T C315(1.08); C398(0.65); C159(1.06); C194(1.21)  LDD1694  [14]
 LDCM0492  CL97 HEK-293T C315(1.00); C398(0.99); C159(0.98); C194(0.92)  LDD1695  [14]
 LDCM0493  CL98 HEK-293T C315(0.99); C398(1.09); C159(1.14); C194(0.87)  LDD1696  [14]
 LDCM0494  CL99 HEK-293T C315(1.08); C398(1.15); C159(0.94); C194(0.91)  LDD1697  [14]
 LDCM0495  E2913 HEK-293T C315(0.93); C398(1.10); C159(0.96); C194(1.42)  LDD1698  [14]
 LDCM0625  F8 Ramos C315(0.86); C398(0.89)  LDD2187  [16]
 LDCM0572  Fragment10 Ramos C315(0.92)  LDD2189  [16]
 LDCM0573  Fragment11 Ramos C315(0.00); C398(0.37)  LDD2190  [16]
 LDCM0574  Fragment12 Ramos C315(1.79)  LDD2191  [16]
 LDCM0575  Fragment13 Ramos C315(1.31)  LDD2192  [16]
 LDCM0576  Fragment14 Ramos C315(1.21); C398(0.84)  LDD2193  [16]
 LDCM0579  Fragment20 Ramos C315(2.34)  LDD2194  [16]
 LDCM0580  Fragment21 Ramos C315(0.64)  LDD2195  [16]
 LDCM0582  Fragment23 Ramos C315(0.96)  LDD2196  [16]
 LDCM0578  Fragment27 Ramos C315(0.91)  LDD2197  [16]
 LDCM0586  Fragment28 Ramos C315(0.74); C398(1.12)  LDD2198  [16]
 LDCM0588  Fragment30 Ramos C315(1.44)  LDD2199  [16]
 LDCM0589  Fragment31 Ramos C315(1.05)  LDD2200  [16]
 LDCM0590  Fragment32 Ramos C315(0.90)  LDD2201  [16]
 LDCM0468  Fragment33 PaTu 8988t C315(0.74)  LDD1347  [15]
 LDCM0596  Fragment38 Ramos C315(1.39)  LDD2203  [16]
 LDCM0566  Fragment4 Ramos C315(0.94); C398(0.60)  LDD2184  [16]
 LDCM0427  Fragment51 HEK-293T C315(1.11); C398(1.12); C159(1.21); C194(0.93)  LDD1631  [14]
 LDCM0610  Fragment52 Ramos C315(1.90)  LDD2204  [16]
 LDCM0614  Fragment56 Ramos C315(1.36)  LDD2205  [16]
 LDCM0569  Fragment7 Ramos C315(1.27); C398(0.80)  LDD2186  [16]
 LDCM0571  Fragment9 Ramos C315(1.68)  LDD2188  [16]
 LDCM0116  HHS-0101 DM93 Y94(3.20)  LDD0264  [3]
 LDCM0117  HHS-0201 DM93 Y94(2.94)  LDD0265  [3]
 LDCM0022  KB02 HEK-293T C315(0.96); C398(1.23); C194(1.15); C343(0.97)  LDD1492  [14]
 LDCM0023  KB03 HEK-293T C315(1.01); C398(0.86); C194(1.08); C343(0.92)  LDD1497  [14]
 LDCM0024  KB05 MKN45 C343(0.74)  LDD3332  [2]

References

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Mass spectrometry data entry: PXD028270
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
4 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
5 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
9 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
14 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
15 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
16 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578