Details of the Target

General Information of Target

Target ID LDTP02683
Target Name Translationally-controlled tumor protein (TPT1)
Gene Name TPT1
Gene ID 7178
Synonyms
Translationally-controlled tumor protein; TCTP; Fortilin; Histamine-releasing factor; HRF; p23
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MIIYRDLISHDEMFSDIYKIREIADGLCLEVEGKMVSRTEGNIDDSLIGGNASAEGPEGE
GTESTVITGVDIVMNHHLQETSFTKEAYKKYIKDYMKSIKGKLEEQRPERVKPFMTGAAE
QIKHILANFKNYQFFIGENMNPDGMVALLDYREDGVTPYMIFFKDGLEMEKC
Target Type
Discontinued
Target Bioclass
Other
Family
TCTP family
Subcellular location
Cytoplasm
Function Involved in calcium binding and microtubule stabilization. Acts as a negative regulator of TSC22D1-mediated apoptosis, via interaction with and destabilization of TSC22D1 protein.
TTD ID
T77473
Uniprot ID
P13693
DrugMap ID
TT3PTB6
Ensemble ID
ENST00000379055.5
HGNC ID
HGNC:12022

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
JURKAT SNV: p.A119T .
LU65 SNV: p.H76Y DBIA    Probe Info 
MCAS SNV: p.K100N .
MFE319 SNV: p.R38G .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 37 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
P3
 Probe Info  		10.00  LDD0450  [2]
P8
 Probe Info  		10.00  LDD0451  [2]
TH211
 Probe Info  		Y18(6.81)  LDD0260  [3]
STPyne
 Probe Info  		K112(5.88); K19(3.29); K90(3.63); K93(7.63)  LDD0277  [4]
ONAyne
 Probe Info  		N.A.  LDD0273  [4]
DBIA
 Probe Info  		C28(0.80)  LDD3310  [5]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [6]
THZ1-DTB
 Probe Info  		C28(1.02)  LDD0460  [6]
BTD
 Probe Info  		C172(2.14)  LDD1700  [7]
Jackson_14
 Probe Info  		2.00  LDD0123  [8]
AHL-Pu-1
 Probe Info  		C172(2.40)  LDD0169  [9]
HHS-482
 Probe Info  		Y91(1.86); Y95(0.88)  LDD0285  [10]
HHS-475
 Probe Info  		Y91(0.84)  LDD0264  [11]
5E-2FA
 Probe Info  		H10(0.00); H124(0.00)  LDD2235  [12]
ATP probe
 Probe Info  		K19(0.00); K112(0.00)  LDD0199  [13]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [14]
IA-alkyne
 Probe Info  		C28(0.00); C172(0.00)  LDD0032  [15]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [16]
IPIAA_L
 Probe Info  		C28(0.00); C172(0.00)  LDD0031  [16]
Lodoacetamide azide
 Probe Info  		C172(0.00); C28(0.00)  LDD0037  [14]
ATP probe
 Probe Info  		N.A.  LDD0035  [17]
IPM
 Probe Info  		N.A.  LDD0025  [18]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [18]
TFBX
 Probe Info  		N.A.  LDD0027  [18]
WYneO
 Probe Info  		N.A.  LDD0022  [19]
ENE
 Probe Info  		N.A.  LDD0006  [19]
1c-yne
 Probe Info  		K112(0.00); K164(0.00)  LDD0228  [20]
Acrolein
 Probe Info  		C28(0.00); K171(0.00); H77(0.00)  LDD0217  [21]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [21]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [21]
Methacrolein
 Probe Info  		C28(0.00); K171(0.00)  LDD0218  [21]
AOyne
 Probe Info  		7.40  LDD0443  [22]
MPP-AC
 Probe Info  		N.A.  LDD0428  [23]
NAIA_5
 Probe Info  		C172(0.00); C28(0.00)  LDD2223  [24]
TER-AC
 Probe Info  		N.A.  LDD0426  [23]
HHS-465
 Probe Info  		K93(0.00); Y91(0.00); K112(0.00)  LDD2240  [25]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe12
 Probe Info  		5.24  LDD0473  [26]
FFF probe3
 Probe Info  		20.00  LDD0464  [26]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C172(0.67); C28(0.93)  LDD2142  [7]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C172(0.74)  LDD2112  [7]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C172(0.85); C28(0.54)  LDD2095  [7]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C172(0.82); C28(0.77)  LDD2130  [7]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C172(1.46); C28(2.25)  LDD2117  [7]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C172(1.79); C28(2.23)  LDD2152  [7]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C172(0.90)  LDD2103  [7]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C172(0.63); C28(0.62)  LDD2132  [7]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C172(0.79); C28(0.82)  LDD2131  [7]
 LDCM0025  4SU-RNA HEK-293T C172(2.01)  LDD0371  [9]
 LDCM0026  4SU-RNA+native RNA HEK-293T C172(2.40)  LDD0169  [9]
 LDCM0214  AC1 HEK-293T C28(0.95)  LDD1507  [27]
 LDCM0215  AC10 HEK-293T C28(1.00)  LDD1508  [27]
 LDCM0226  AC11 HEK-293T C28(1.00)  LDD1509  [27]
 LDCM0237  AC12 HEK-293T C28(1.02)  LDD1510  [27]
 LDCM0259  AC14 HEK-293T C28(1.10)  LDD1512  [27]
 LDCM0270  AC15 HEK-293T C28(0.99)  LDD1513  [27]
 LDCM0276  AC17 HEK-293T C28(1.02)  LDD1515  [27]
 LDCM0277  AC18 HEK-293T C28(1.01)  LDD1516  [27]
 LDCM0278  AC19 HEK-293T C28(0.91)  LDD1517  [27]
 LDCM0279  AC2 HEK-293T C28(1.03)  LDD1518  [27]
 LDCM0280  AC20 HEK-293T C28(1.01)  LDD1519  [27]
 LDCM0281  AC21 HEK-293T C28(1.02)  LDD1520  [27]
 LDCM0282  AC22 HEK-293T C28(1.11)  LDD1521  [27]
 LDCM0283  AC23 HEK-293T C28(0.99)  LDD1522  [27]
 LDCM0284  AC24 HEK-293T C28(1.04)  LDD1523  [27]
 LDCM0285  AC25 HEK-293T C28(0.97)  LDD1524  [27]
 LDCM0286  AC26 HEK-293T C28(0.99)  LDD1525  [27]
 LDCM0287  AC27 HEK-293T C28(1.03)  LDD1526  [27]
 LDCM0288  AC28 HEK-293T C28(1.01)  LDD1527  [27]
 LDCM0289  AC29 HEK-293T C28(1.01)  LDD1528  [27]
 LDCM0290  AC3 HEK-293T C28(1.06)  LDD1529  [27]
 LDCM0291  AC30 HEK-293T C28(1.10)  LDD1530  [27]
 LDCM0292  AC31 HEK-293T C28(0.92)  LDD1531  [27]
 LDCM0293  AC32 HEK-293T C28(1.10)  LDD1532  [27]
 LDCM0294  AC33 HEK-293T C28(0.98)  LDD1533  [27]
 LDCM0295  AC34 HEK-293T C28(0.99)  LDD1534  [27]
 LDCM0296  AC35 HEK-293T C28(1.03)  LDD1535  [27]
 LDCM0297  AC36 HEK-293T C28(0.98)  LDD1536  [27]
 LDCM0298  AC37 HEK-293T C28(1.16)  LDD1537  [27]
 LDCM0299  AC38 HEK-293T C28(1.10)  LDD1538  [27]
 LDCM0300  AC39 HEK-293T C28(0.91)  LDD1539  [27]
 LDCM0301  AC4 HEK-293T C28(1.00)  LDD1540  [27]
 LDCM0302  AC40 HEK-293T C28(1.15)  LDD1541  [27]
 LDCM0303  AC41 HEK-293T C28(0.94)  LDD1542  [27]
 LDCM0304  AC42 HEK-293T C28(0.93)  LDD1543  [27]
 LDCM0305  AC43 HEK-293T C28(1.02)  LDD1544  [27]
 LDCM0306  AC44 HEK-293T C28(1.03)  LDD1545  [27]
 LDCM0307  AC45 HEK-293T C28(1.13)  LDD1546  [27]
 LDCM0308  AC46 HEK-293T C28(1.01)  LDD1547  [27]
 LDCM0309  AC47 HEK-293T C28(0.96)  LDD1548  [27]
 LDCM0310  AC48 HEK-293T C28(1.10)  LDD1549  [27]
 LDCM0311  AC49 HEK-293T C28(0.98)  LDD1550  [27]
 LDCM0312  AC5 HEK-293T C28(1.08)  LDD1551  [27]
 LDCM0313  AC50 HEK-293T C28(1.02)  LDD1552  [27]
 LDCM0314  AC51 HEK-293T C28(1.04)  LDD1553  [27]
 LDCM0315  AC52 HEK-293T C28(0.98)  LDD1554  [27]
 LDCM0316  AC53 HEK-293T C28(1.08)  LDD1555  [27]
 LDCM0317  AC54 HEK-293T C28(1.06)  LDD1556  [27]
 LDCM0318  AC55 HEK-293T C28(0.91)  LDD1557  [27]
 LDCM0319  AC56 HEK-293T C28(1.06)  LDD1558  [27]
 LDCM0320  AC57 HEK-293T C28(1.01)  LDD1559  [27]
 LDCM0321  AC58 HEK-293T C28(1.05)  LDD1560  [27]
 LDCM0322  AC59 HEK-293T C28(1.02)  LDD1561  [27]
 LDCM0323  AC6 HEK-293T C28(1.02)  LDD1562  [27]
 LDCM0324  AC60 HEK-293T C28(0.98)  LDD1563  [27]
 LDCM0325  AC61 HEK-293T C28(1.10)  LDD1564  [27]
 LDCM0326  AC62 HEK-293T C28(1.12)  LDD1565  [27]
 LDCM0327  AC63 HEK-293T C28(0.95)  LDD1566  [27]
 LDCM0328  AC64 HEK-293T C28(1.07)  LDD1567  [27]
 LDCM0334  AC7 HEK-293T C28(1.00)  LDD1568  [27]
 LDCM0345  AC8 HEK-293T C28(1.08)  LDD1569  [27]
 LDCM0545  Acetamide MDA-MB-231 C172(0.59); C28(0.94)  LDD2138  [7]
 LDCM0520  AKOS000195272 MDA-MB-231 C172(0.84); C28(0.85)  LDD2113  [7]
 LDCM0248  AKOS034007472 HEK-293T C28(1.07)  LDD1511  [27]
 LDCM0356  AKOS034007680 HEK-293T C28(0.96)  LDD1570  [27]
 LDCM0275  AKOS034007705 HEK-293T C28(1.11)  LDD1514  [27]
 LDCM0156  Aniline NCI-H1299 11.19  LDD0403  [1]
 LDCM0498  BS-3668 MDA-MB-231 C172(0.58); C28(0.94)  LDD2091  [7]
 LDCM0108  Chloroacetamide HeLa C28(0.00); K171(0.00); H10(0.00)  LDD0222  [21]
 LDCM0367  CL1 HEK-293T C28(1.12)  LDD1571  [27]
 LDCM0368  CL10 HEK-293T C28(1.15)  LDD1572  [27]
 LDCM0369  CL100 HEK-293T C28(1.00)  LDD1573  [27]
 LDCM0370  CL101 HEK-293T C28(1.02)  LDD1574  [27]
 LDCM0371  CL102 HEK-293T C28(0.96)  LDD1575  [27]
 LDCM0372  CL103 HEK-293T C28(1.02)  LDD1576  [27]
 LDCM0373  CL104 HEK-293T C28(1.03)  LDD1577  [27]
 LDCM0374  CL105 HEK-293T C28(1.02)  LDD1578  [27]
 LDCM0375  CL106 HEK-293T C28(0.93)  LDD1579  [27]
 LDCM0376  CL107 HEK-293T C28(1.03)  LDD1580  [27]
 LDCM0377  CL108 HEK-293T C28(1.05)  LDD1581  [27]
 LDCM0378  CL109 HEK-293T C28(0.89)  LDD1582  [27]
 LDCM0379  CL11 HEK-293T C28(1.08)  LDD1583  [27]
 LDCM0380  CL110 HEK-293T C28(0.92)  LDD1584  [27]
 LDCM0381  CL111 HEK-293T C28(1.00)  LDD1585  [27]
 LDCM0382  CL112 HEK-293T C28(1.01)  LDD1586  [27]
 LDCM0383  CL113 HEK-293T C28(1.09)  LDD1587  [27]
 LDCM0384  CL114 HEK-293T C28(0.93)  LDD1588  [27]
 LDCM0385  CL115 HEK-293T C28(1.06)  LDD1589  [27]
 LDCM0386  CL116 HEK-293T C28(0.99)  LDD1590  [27]
 LDCM0387  CL117 HEK-293T C28(1.06)  LDD1591  [27]
 LDCM0388  CL118 HEK-293T C28(1.06)  LDD1592  [27]
 LDCM0389  CL119 HEK-293T C28(1.14)  LDD1593  [27]
 LDCM0390  CL12 HEK-293T C28(1.30)  LDD1594  [27]
 LDCM0391  CL120 HEK-293T C28(1.03)  LDD1595  [27]
 LDCM0392  CL121 HEK-293T C28(1.02)  LDD1596  [27]
 LDCM0393  CL122 HEK-293T C28(0.95)  LDD1597  [27]
 LDCM0394  CL123 HEK-293T C28(0.97)  LDD1598  [27]
 LDCM0395  CL124 HEK-293T C28(1.01)  LDD1599  [27]
 LDCM0396  CL125 HEK-293T C28(1.11)  LDD1600  [27]
 LDCM0397  CL126 HEK-293T C28(1.00)  LDD1601  [27]
 LDCM0398  CL127 HEK-293T C28(1.00)  LDD1602  [27]
 LDCM0399  CL128 HEK-293T C28(0.97)  LDD1603  [27]
 LDCM0400  CL13 HEK-293T C28(1.05)  LDD1604  [27]
 LDCM0401  CL14 HEK-293T C28(1.15)  LDD1605  [27]
 LDCM0402  CL15 HEK-293T C28(0.99)  LDD1606  [27]
 LDCM0403  CL16 HEK-293T C28(1.11)  LDD1607  [27]
 LDCM0404  CL17 HEK-293T C28(0.91)  LDD1608  [27]
 LDCM0405  CL18 HEK-293T C28(1.17)  LDD1609  [27]
 LDCM0406  CL19 HEK-293T C28(1.17)  LDD1610  [27]
 LDCM0407  CL2 HEK-293T C28(1.00)  LDD1611  [27]
 LDCM0408  CL20 HEK-293T C28(1.22)  LDD1612  [27]
 LDCM0409  CL21 HEK-293T C28(1.13)  LDD1613  [27]
 LDCM0410  CL22 HEK-293T C28(1.34)  LDD1614  [27]
 LDCM0411  CL23 HEK-293T C28(1.26)  LDD1615  [27]
 LDCM0412  CL24 HEK-293T C28(1.21)  LDD1616  [27]
 LDCM0413  CL25 HEK-293T C28(0.93)  LDD1617  [27]
 LDCM0414  CL26 HEK-293T C28(0.88)  LDD1618  [27]
 LDCM0415  CL27 HEK-293T C28(1.16)  LDD1619  [27]
 LDCM0416  CL28 HEK-293T C28(1.04)  LDD1620  [27]
 LDCM0417  CL29 HEK-293T C28(1.03)  LDD1621  [27]
 LDCM0418  CL3 HEK-293T C28(1.00)  LDD1622  [27]
 LDCM0419  CL30 HEK-293T C28(1.06)  LDD1623  [27]
 LDCM0420  CL31 HEK-293T C28(1.06)  LDD1624  [27]
 LDCM0421  CL32 HEK-293T C28(1.20)  LDD1625  [27]
 LDCM0422  CL33 HEK-293T C28(1.12)  LDD1626  [27]
 LDCM0423  CL34 HEK-293T C28(1.38)  LDD1627  [27]
 LDCM0424  CL35 HEK-293T C28(1.27)  LDD1628  [27]
 LDCM0425  CL36 HEK-293T C28(1.22)  LDD1629  [27]
 LDCM0426  CL37 HEK-293T C28(0.93)  LDD1630  [27]
 LDCM0428  CL39 HEK-293T C28(1.03)  LDD1632  [27]
 LDCM0429  CL4 HEK-293T C28(1.07)  LDD1633  [27]
 LDCM0430  CL40 HEK-293T C28(1.07)  LDD1634  [27]
 LDCM0431  CL41 HEK-293T C28(0.97)  LDD1635  [27]
 LDCM0432  CL42 HEK-293T C28(1.09)  LDD1636  [27]
 LDCM0433  CL43 HEK-293T C28(1.14)  LDD1637  [27]
 LDCM0434  CL44 HEK-293T C28(1.14)  LDD1638  [27]
 LDCM0435  CL45 HEK-293T C28(1.15)  LDD1639  [27]
 LDCM0436  CL46 HEK-293T C28(1.42)  LDD1640  [27]
 LDCM0437  CL47 HEK-293T C28(1.27)  LDD1641  [27]
 LDCM0438  CL48 HEK-293T C28(1.06)  LDD1642  [27]
 LDCM0439  CL49 HEK-293T C28(1.10)  LDD1643  [27]
 LDCM0440  CL5 HEK-293T C28(1.02)  LDD1644  [27]
 LDCM0441  CL50 HEK-293T C28(1.00)  LDD1645  [27]
 LDCM0443  CL52 HEK-293T C28(1.08)  LDD1646  [27]
 LDCM0444  CL53 HEK-293T C28(1.02)  LDD1647  [27]
 LDCM0445  CL54 HEK-293T C28(0.93)  LDD1648  [27]
 LDCM0446  CL55 HEK-293T C28(1.16)  LDD1649  [27]
 LDCM0447  CL56 HEK-293T C28(1.08)  LDD1650  [27]
 LDCM0448  CL57 HEK-293T C28(1.22)  LDD1651  [27]
 LDCM0449  CL58 HEK-293T C28(1.31)  LDD1652  [27]
 LDCM0450  CL59 HEK-293T C28(1.18)  LDD1653  [27]
 LDCM0451  CL6 HEK-293T C28(0.99)  LDD1654  [27]
 LDCM0452  CL60 HEK-293T C28(1.27)  LDD1655  [27]
 LDCM0453  CL61 HEK-293T C28(1.08)  LDD1656  [27]
 LDCM0454  CL62 HEK-293T C28(0.94)  LDD1657  [27]
 LDCM0455  CL63 HEK-293T C28(1.08)  LDD1658  [27]
 LDCM0456  CL64 HEK-293T C28(0.99)  LDD1659  [27]
 LDCM0457  CL65 HEK-293T C28(1.04)  LDD1660  [27]
 LDCM0458  CL66 HEK-293T C28(1.02)  LDD1661  [27]
 LDCM0459  CL67 HEK-293T C28(1.03)  LDD1662  [27]
 LDCM0460  CL68 HEK-293T C28(1.11)  LDD1663  [27]
 LDCM0461  CL69 HEK-293T C28(0.66)  LDD1664  [27]
 LDCM0462  CL7 HEK-293T C28(1.14)  LDD1665  [27]
 LDCM0463  CL70 HEK-293T C28(1.26)  LDD1666  [27]
 LDCM0464  CL71 HEK-293T C28(1.21)  LDD1667  [27]
 LDCM0465  CL72 HEK-293T C28(1.40)  LDD1668  [27]
 LDCM0466  CL73 HEK-293T C28(1.02)  LDD1669  [27]
 LDCM0467  CL74 HEK-293T C28(1.00)  LDD1670  [27]
 LDCM0469  CL76 HEK-293T C28(1.01)  LDD1672  [27]
 LDCM0470  CL77 HEK-293T C28(0.92)  LDD1673  [27]
 LDCM0471  CL78 HEK-293T C28(1.08)  LDD1674  [27]
 LDCM0472  CL79 HEK-293T C28(1.09)  LDD1675  [27]
 LDCM0473  CL8 HEK-293T C28(1.02)  LDD1676  [27]
 LDCM0474  CL80 HEK-293T C28(1.13)  LDD1677  [27]
 LDCM0475  CL81 HEK-293T C28(1.25)  LDD1678  [27]
 LDCM0476  CL82 HEK-293T C28(1.30)  LDD1679  [27]
 LDCM0477  CL83 HEK-293T C28(1.12)  LDD1680  [27]
 LDCM0478  CL84 HEK-293T C28(1.19)  LDD1681  [27]
 LDCM0479  CL85 HEK-293T C28(1.04)  LDD1682  [27]
 LDCM0480  CL86 HEK-293T C28(0.97)  LDD1683  [27]
 LDCM0481  CL87 HEK-293T C28(1.10)  LDD1684  [27]
 LDCM0482  CL88 HEK-293T C28(1.12)  LDD1685  [27]
 LDCM0483  CL89 HEK-293T C28(1.01)  LDD1686  [27]
 LDCM0484  CL9 HEK-293T C28(1.18)  LDD1687  [27]
 LDCM0485  CL90 HEK-293T C28(0.91)  LDD1688  [27]
 LDCM0486  CL91 HEK-293T C28(1.08)  LDD1689  [27]
 LDCM0487  CL92 HEK-293T C28(0.99)  LDD1690  [27]
 LDCM0488  CL93 HEK-293T C28(1.17)  LDD1691  [27]
 LDCM0489  CL94 HEK-293T C28(1.21)  LDD1692  [27]
 LDCM0490  CL95 HEK-293T C28(0.91)  LDD1693  [27]
 LDCM0491  CL96 HEK-293T C28(1.08)  LDD1694  [27]
 LDCM0492  CL97 HEK-293T C28(0.97)  LDD1695  [27]
 LDCM0493  CL98 HEK-293T C28(0.98)  LDD1696  [27]
 LDCM0494  CL99 HEK-293T C28(1.00)  LDD1697  [27]
 LDCM0495  E2913 HEK-293T C28(1.06)  LDD1698  [27]
 LDCM0572  Fragment10 Ramos C28(0.85)  LDD2189  [28]
 LDCM0574  Fragment12 Ramos C28(1.00)  LDD2191  [28]
 LDCM0575  Fragment13 Ramos C28(1.10)  LDD2192  [28]
 LDCM0579  Fragment20 Ramos C28(0.93)  LDD2194  [28]
 LDCM0580  Fragment21 Ramos C28(1.36)  LDD2195  [28]
 LDCM0582  Fragment23 Ramos C28(1.59)  LDD2196  [28]
 LDCM0578  Fragment27 Ramos C28(1.27)  LDD2197  [28]
 LDCM0586  Fragment28 Ramos C28(0.52)  LDD2198  [28]
 LDCM0588  Fragment30 Ramos C28(1.34)  LDD2199  [28]
 LDCM0589  Fragment31 Ramos C28(1.37)  LDD2200  [28]
 LDCM0590  Fragment32 Ramos C28(0.90)  LDD2201  [28]
 LDCM0468  Fragment33 HEK-293T C28(1.10)  LDD1671  [27]
 LDCM0596  Fragment38 Ramos C28(0.98)  LDD2203  [28]
 LDCM0566  Fragment4 Ramos C28(0.84)  LDD2184  [28]
 LDCM0427  Fragment51 HEK-293T C28(0.97)  LDD1631  [27]
 LDCM0610  Fragment52 Ramos C28(0.57)  LDD2204  [28]
 LDCM0614  Fragment56 Ramos C28(0.90)  LDD2205  [28]
 LDCM0569  Fragment7 Ramos C28(0.80)  LDD2186  [28]
 LDCM0571  Fragment9 Ramos C28(0.75)  LDD2188  [28]
 LDCM0116  HHS-0101 DM93 Y91(0.84)  LDD0264  [11]
 LDCM0117  HHS-0201 DM93 Y91(0.64)  LDD0265  [11]
 LDCM0118  HHS-0301 DM93 Y91(0.88)  LDD0266  [11]
 LDCM0119  HHS-0401 DM93 Y91(0.65)  LDD0267  [11]
 LDCM0120  HHS-0701 DM93 Y91(0.61)  LDD0268  [11]
 LDCM0107  IAA HeLa C28(0.00); H10(0.00)  LDD0221  [21]
 LDCM0123  JWB131 DM93 Y91(1.86); Y95(0.88)  LDD0285  [10]
 LDCM0124  JWB142 DM93 Y95(0.60)  LDD0286  [10]
 LDCM0125  JWB146 DM93 Y91(0.92); Y95(1.09)  LDD0287  [10]
 LDCM0126  JWB150 DM93 Y91(7.01); Y95(1.94)  LDD0288  [10]
 LDCM0127  JWB152 DM93 Y91(3.43); Y95(1.48)  LDD0289  [10]
 LDCM0128  JWB198 DM93 Y91(2.00); Y95(0.47)  LDD0290  [10]
 LDCM0129  JWB202 DM93 Y91(0.45); Y95(0.62)  LDD0291  [10]
 LDCM0130  JWB211 DM93 Y91(0.81); Y95(0.47)  LDD0292  [10]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [6]
 LDCM0022  KB02 HEK-293T C28(0.96)  LDD1492  [27]
 LDCM0023  KB03 HEK-293T C28(1.00)  LDD1497  [27]
 LDCM0024  KB05 COLO792 C28(0.80)  LDD3310  [5]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C172(1.02); C28(0.74)  LDD2102  [7]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C172(0.53); C28(0.80)  LDD2121  [7]
 LDCM0109  NEM HeLa C28(0.00); H10(0.00)  LDD0223  [21]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C172(0.71); C28(0.99)  LDD2089  [7]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C28(1.44)  LDD2090  [7]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C172(0.92)  LDD2092  [7]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C172(1.16); C28(1.70)  LDD2093  [7]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C172(1.04)  LDD2094  [7]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C28(0.34)  LDD2096  [7]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C172(0.98)  LDD2097  [7]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C172(0.89); C28(1.13)  LDD2098  [7]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C172(1.23); C28(1.35)  LDD2099  [7]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C172(0.58); C28(0.85)  LDD2100  [7]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C172(0.87); C28(1.03)  LDD2101  [7]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C172(0.70); C28(0.71)  LDD2104  [7]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C172(1.01); C28(1.24)  LDD2105  [7]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C172(0.79); C28(0.69)  LDD2106  [7]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C172(1.09)  LDD2107  [7]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C172(0.70); C28(0.94)  LDD2108  [7]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C172(0.78); C28(0.80)  LDD2109  [7]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C172(0.67)  LDD2110  [7]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C172(1.63); C28(2.04)  LDD2111  [7]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C172(0.63); C28(1.04)  LDD2114  [7]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C172(0.49); C28(0.33)  LDD2115  [7]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C172(0.89); C28(0.67)  LDD2116  [7]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C28(0.72)  LDD2118  [7]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C172(3.11); C28(1.98)  LDD2119  [7]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C172(0.76); C28(0.90)  LDD2120  [7]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C172(1.03); C28(0.63)  LDD2122  [7]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C172(1.10); C28(1.26)  LDD2123  [7]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C28(0.87)  LDD2124  [7]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C172(1.13)  LDD2125  [7]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C172(0.94); C28(1.15)  LDD2126  [7]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C172(1.30); C28(1.53)  LDD2127  [7]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C172(1.02); C28(1.21)  LDD2128  [7]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C172(1.45)  LDD2129  [7]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C172(0.46); C28(0.81)  LDD2133  [7]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C172(0.41); C28(0.43)  LDD2134  [7]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C172(1.52); C28(3.19)  LDD2135  [7]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C172(1.36); C28(1.42)  LDD2136  [7]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C172(1.07); C28(1.14)  LDD2137  [7]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C172(2.14)  LDD1700  [7]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C172(1.04); C28(1.70)  LDD2140  [7]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C172(0.84); C28(1.05)  LDD2141  [7]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C172(1.01); C28(1.02)  LDD2143  [7]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C172(2.81); C28(1.75)  LDD2144  [7]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C172(0.77)  LDD2145  [7]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C172(1.17); C28(1.72)  LDD2146  [7]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C172(3.10); C28(1.97)  LDD2147  [7]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C172(0.42); C28(0.42)  LDD2148  [7]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C172(1.25); C28(0.38)  LDD2149  [7]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C172(0.56); C28(0.80)  LDD2150  [7]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C172(0.76)  LDD2151  [7]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C172(1.31); C28(2.07)  LDD2153  [7]
 LDCM0131  RA190 MM1.R C28(1.21); C172(0.91)  LDD0304  [29]
 LDCM0016  Ranjitkar_cp1 MDA-MB-231 2.00  LDD0123  [8]
 LDCM0021  THZ1 HeLa S3 C28(1.02)  LDD0460  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Pachytene checkpoint protein 2 homolog (TRIP13) AAA ATPase family Q15645
Actin, cytoplasmic 1 (ACTB) Actin family P60709
Sodium/potassium-transporting ATPase subunit alpha-1 (ATP1A1) Cation transport ATPase (P-type) (TC 3.A.3) family P05023
X-ray repair cross-complementing protein 6 (XRCC6) Ku70 family P12956
X-ray repair cross-complementing protein 5 (XRCC5) Ku80 family P13010
Peroxiredoxin-1 (PRDX1) Peroxiredoxin family Q06830
GTP-binding protein Rheb (RHEB) Rheb family Q15382
Tubulin alpha-1C chain (TUBA1C) Tubulin family Q9BQE3
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cellular tumor antigen p53 (TP53) P53 family P04637
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
TSC22 domain family protein 1 (TSC22D1) TSC-22/Dip/Bun family Q15714
Y-box-binding protein 1 (YBX1) YBX1 family P67809
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Elongation factor 1-delta (EEF1D) EF-1-beta/EF-1-delta family P29692
Stress-70 protein, mitochondrial (HSPA9) Heat shock protein 70 family P38646
Heat shock protein beta-1 (HSPB1) Small heat shock protein (HSP20) family P04792

The Drug(s) Related To This Target

Approved
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Calcium Phosphate Small molecular drug DB11348
Calcium Phosphate Dihydrate Small molecular drug DB14481
Calcium Citrate . DB11093
Discontinued
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Cer-227185 . D01CEQ

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
6 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
9 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
10 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
11 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
12 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
13 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
14 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
15 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
16 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
17 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
18 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
19 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
20 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
21 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
22 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
23 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
24 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
25 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
26 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
27 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
28 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
29 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.