Details of the Target

General Information of Target

Target ID LDTP06067
Target Name Tubulin--tyrosine ligase-like protein 12 (TTLL12)
Gene Name TTLL12
Gene ID 23170
Synonyms
KIAA0153; Tubulin--tyrosine ligase-like protein 12; Inactive tubulin--tyrosine ligase-like protein 12
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEAERGPERRPAERSSPGQTPEEGAQALAEFAALHGPALRASGVPERYWGRLLHKLEHEV
FDAGEVFGIMQVEEVEEEEDEAAREVRKQQPNPGNELCYKVIVTRESGLQAAHPNSIFLI
DHAWTCRVEHARQQLQQVPGLLHRMANLMGIEFHGELPSTEAVALVLEEMWKFNQTYQLA
HGTAEEKMPVWYIMDEFGSRIQHADVPSFATAPFFYMPQQVAYTLLWPLRDLDTGEEVTR
DFAYGETDPLIRKCMLLPWAPTDMLDLSSCTPEPPAEHYQAILEENKEKLPLDINPVVHP
HGHIFKVYTDVQQVASSLTHPRFTLTQSEADADILFNFSHFKDYRKLSQERPGVLLNQFP
CENLLTVKDCLASIARRAGGPEGPPWLPRTFNLRTELPQFVSYFQQRERWGEDNHWICKP
WNLARSLDTHVTKSLHSIIRHRESTPKVVSKYIESPVLFLREDVGKVKFDIRYIVLLRSV
RPLRLFVYDVFWLRFSNRAFALNDLDDYEKHFTVMNYDPDVVLKQVHCEEFIPEFEKQYP
EFPWTDVQAEIFRAFTELFQVACAKPPPLGLCDYPSSRAMYAVDLMLKWDNGPDGRRVMQ
PQILEVNFNPDCERACRYHPTFFNDVFSTLFLDQPGGCHVTCLV
Target Bioclass
Enzyme
Family
Tubulin--tyrosine ligase family
Subcellular location
Cytoplasm
Function
Negatively regulates post-translational modifications of tubulin, including detyrosination of the C-terminus and polyglutamylation of glutamate residues. Also, indirectly promotes histone H4 trimethylation at 'Lys-20' (H4K20me3). Probably by controlling tubulin and/or histone H4 post-translational modifications, plays a role in mitosis and in maintaining chromosome number stability. During RNA virus-mediated infection, acts as a negative regulator of the RIG-I pathway by preventing MAVS binding to TBK1 and IKBKE.
Uniprot ID
Q14166
Ensemble ID
ENST00000216129.7
HGNC ID
HGNC:28974

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 41 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
P3
 Probe Info  		10.00  LDD0450  [2]
P8
 Probe Info  		10.00  LDD0451  [2]
A-EBA
 Probe Info  		4.13  LDD0215  [3]
CY-1
 Probe Info  		100.00  LDD0243  [4]
TH211
 Probe Info  		Y452(17.73); Y473(14.36); Y308(13.93); Y244(9.73)  LDD0257  [5]
TH216
 Probe Info  		Y452(20.00)  LDD0259  [5]
YN-1
 Probe Info  		100.00  LDD0444  [6]
STPyne
 Probe Info  		K368(3.30)  LDD2217  [7]
BTD
 Probe Info  		C370(0.21)  LDD1699  [8]
ONAyne
 Probe Info  		K447(10.00)  LDD0275  [9]
Probe 1
 Probe Info  		Y508(86.10)  LDD3495  [10]
AF-1
 Probe Info  		2.21  LDD0421  [11]
DA-P3
 Probe Info  		11.57  LDD0183  [12]
AHL-Pu-1
 Probe Info  		C361(10.66)  LDD0170  [13]
HHS-482
 Probe Info  		Y403(0.32); Y517(0.05)  LDD0286  [14]
HHS-475
 Probe Info  		Y473(0.79); Y403(0.84); Y452(0.86); Y517(0.93)  LDD0264  [15]
HHS-465
 Probe Info  		Y308(2.54); Y403(10.00); Y452(10.00); Y473(10.00)  LDD2237  [16]
DBIA
 Probe Info  		C528(1.04); C98(1.03)  LDD0078  [17]
5E-2FA
 Probe Info  		H181(0.00); H35(0.00)  LDD2235  [18]
AMP probe
 Probe Info  		N.A.  LDD0200  [19]
ATP probe
 Probe Info  		N.A.  LDD0199  [19]
4-Iodoacetamidophenylacetylene
 Probe Info  		C370(0.00); C126(0.00); C98(0.00); C361(0.00)  LDD0038  [20]
IA-alkyne
 Probe Info  		C126(0.00); C361(0.00); C563(0.00)  LDD0032  [21]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [22]
IPIAA_L
 Probe Info  		C361(0.00); C126(0.00); C418(0.00); C563(0.00)  LDD0031  [22]
Lodoacetamide azide
 Probe Info  		C126(0.00); C98(0.00); C361(0.00); C612(0.00)  LDD0037  [20]
ATP probe
 Probe Info  		K419(0.00); K342(0.00); K368(0.00)  LDD0035  [23]
JW-RF-010
 Probe Info  		C98(0.00); C612(0.00)  LDD0026  [24]
NAIA_4
 Probe Info  		N.A.  LDD2226  [25]
TFBX
 Probe Info  		C98(0.00); C612(0.00)  LDD0027  [24]
KY-26
 Probe Info  		N.A.  LDD0301  [26]
Compound 10
 Probe Info  		C361(0.00); C370(0.00)  LDD2216  [27]
IPM
 Probe Info  		N.A.  LDD0005  [28]
SF
 Probe Info  		Y308(0.00); Y403(0.00); Y473(0.00); Y452(0.00)  LDD0028  [29]
1c-yne
 Probe Info  		K88(0.00); K187(0.00); K342(0.00)  LDD0228  [30]
Acrolein
 Probe Info  		C361(0.00); C98(0.00); C528(0.00); C612(0.00)  LDD0217  [31]
Methacrolein
 Probe Info  		N.A.  LDD0218  [31]
W1
 Probe Info  		C361(0.00); C528(0.00); C612(0.00); C98(0.00)  LDD0236  [32]
AOyne
 Probe Info  		6.00  LDD0443  [33]
NAIA_5
 Probe Info  		C370(0.00); C418(0.00); C126(0.00); C361(0.00)  LDD2223  [25]
PAL-AfBPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C201
 Probe Info  		63.56  LDD1877  [34]
C226
 Probe Info  		6.02  LDD1899  [34]
C285
 Probe Info  		24.93  LDD1955  [34]
C356
 Probe Info  		7.84  LDD2017  [34]
FFF probe11
 Probe Info  		6.53  LDD0472  [35]
FFF probe12
 Probe Info  		5.65  LDD0473  [35]
FFF probe13
 Probe Info  		5.10  LDD0476  [35]
FFF probe3
 Probe Info  		7.58  LDD0465  [35]
FFF probe4
 Probe Info  		20.00  LDD0466  [35]
JN0003
 Probe Info  		20.00  LDD0469  [35]
STS-1
 Probe Info  		N.A.  LDD0136  [36]
STS-2
 Probe Info  		1.19  LDD0139  [36]
VE-P
 Probe Info  		N.A.  LDD0396  [37]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C361(10.66)  LDD0170  [13]
 LDCM0026  4SU-RNA+native RNA DM93 C418(2.34); C361(10.76)  LDD0171  [13]
 LDCM0214  AC1 HCT 116 C361(0.89); C126(1.01); C370(1.23); C528(1.06)  LDD0531  [17]
 LDCM0215  AC10 HCT 116 C361(1.16); C370(0.84); C418(1.19); C528(1.19)  LDD0532  [17]
 LDCM0216  AC100 HCT 116 C572(1.04); C563(1.04); C361(1.81); C126(0.65)  LDD0533  [17]
 LDCM0217  AC101 HCT 116 C572(0.59); C563(0.59); C361(1.09); C126(0.65)  LDD0534  [17]
 LDCM0218  AC102 HCT 116 C572(0.38); C563(0.38); C361(1.27); C126(0.70)  LDD0535  [17]
 LDCM0219  AC103 HCT 116 C572(0.07); C563(0.07); C361(1.27); C126(0.24)  LDD0536  [17]
 LDCM0220  AC104 HCT 116 C572(0.12); C563(0.12); C361(1.45); C126(0.34)  LDD0537  [17]
 LDCM0221  AC105 HCT 116 C572(0.11); C563(0.11); C361(1.23); C126(0.26)  LDD0538  [17]
 LDCM0222  AC106 HCT 116 C572(0.08); C563(0.08); C361(1.70); C126(0.27)  LDD0539  [17]
 LDCM0223  AC107 HCT 116 C572(0.21); C563(0.21); C361(1.46); C126(0.18)  LDD0540  [17]
 LDCM0224  AC108 HCT 116 C572(0.16); C563(0.16); C361(1.32); C126(0.93)  LDD0541  [17]
 LDCM0225  AC109 HCT 116 C572(0.15); C563(0.15); C361(1.42); C126(0.91)  LDD0542  [17]
 LDCM0226  AC11 HCT 116 C361(1.45); C370(0.93); C418(1.88); C528(1.10)  LDD0543  [17]
 LDCM0227  AC110 HCT 116 C572(0.15); C563(0.15); C361(1.21); C126(0.98)  LDD0544  [17]
 LDCM0228  AC111 HCT 116 C572(0.16); C563(0.16); C361(1.09); C126(0.74)  LDD0545  [17]
 LDCM0229  AC112 HCT 116 C572(0.15); C563(0.15); C361(0.91); C126(0.44)  LDD0546  [17]
 LDCM0230  AC113 HCT 116 C572(0.96); C563(0.96); C126(1.22); C370(0.86)  LDD0547  [17]
 LDCM0231  AC114 HCT 116 C572(0.83); C563(0.83); C126(0.78); C370(0.71)  LDD0548  [17]
 LDCM0232  AC115 HCT 116 C572(0.38); C563(0.38); C126(0.56); C370(0.54)  LDD0549  [17]
 LDCM0233  AC116 HCT 116 C572(0.44); C563(0.44); C126(0.54); C370(0.56)  LDD0550  [17]
 LDCM0234  AC117 HCT 116 C572(0.88); C563(0.88); C126(0.96); C370(0.94)  LDD0551  [17]
 LDCM0235  AC118 HCT 116 C572(0.82); C563(0.82); C126(0.89); C370(0.97)  LDD0552  [17]
 LDCM0236  AC119 HCT 116 C572(0.68); C563(0.68); C126(0.77); C370(0.82)  LDD0553  [17]
 LDCM0237  AC12 HCT 116 C361(1.76); C370(1.18); C418(1.92); C528(1.06)  LDD0554  [17]
 LDCM0238  AC120 HCT 116 C572(0.67); C563(0.67); C126(0.75); C370(0.69)  LDD0555  [17]
 LDCM0239  AC121 HCT 116 C572(1.03); C563(1.03); C126(1.22); C370(0.91)  LDD0556  [17]
 LDCM0240  AC122 HCT 116 C572(0.64); C563(0.64); C126(0.76); C370(0.81)  LDD0557  [17]
 LDCM0241  AC123 HCT 116 C572(1.47); C563(1.47); C126(1.23); C370(0.90)  LDD0558  [17]
 LDCM0242  AC124 HCT 116 C572(0.93); C563(0.93); C126(0.95); C370(0.88)  LDD0559  [17]
 LDCM0243  AC125 HCT 116 C572(0.79); C563(0.79); C126(0.96); C370(0.81)  LDD0560  [17]
 LDCM0244  AC126 HCT 116 C572(0.47); C563(0.47); C126(0.73); C370(0.57)  LDD0561  [17]
 LDCM0245  AC127 HCT 116 C572(0.55); C563(0.55); C126(0.71); C370(0.65)  LDD0562  [17]
 LDCM0246  AC128 HCT 116 C572(0.55); C361(0.61); C126(1.15); C370(0.80)  LDD0563  [17]
 LDCM0247  AC129 HCT 116 C572(3.96); C361(5.40); C126(1.57); C370(1.38)  LDD0564  [17]
 LDCM0249  AC130 HCT 116 C572(1.21); C361(0.67); C126(0.72); C370(0.72)  LDD0566  [17]
 LDCM0250  AC131 HCT 116 C572(20.00); C361(1.77); C126(1.57); C370(1.27)  LDD0567  [17]
 LDCM0251  AC132 HCT 116 C572(0.99); C361(2.64); C126(1.37); C370(1.70)  LDD0568  [17]
 LDCM0252  AC133 HCT 116 C572(0.53); C361(0.73); C126(0.82); C370(0.82)  LDD0569  [17]
 LDCM0253  AC134 HCT 116 C572(0.62); C361(0.56); C126(0.78); C370(0.67)  LDD0570  [17]
 LDCM0254  AC135 HCT 116 C572(0.67); C361(0.67); C126(0.76); C370(0.72)  LDD0571  [17]
 LDCM0255  AC136 HCT 116 C572(0.66); C361(1.18); C126(0.90); C370(0.73)  LDD0572  [17]
 LDCM0256  AC137 HCT 116 C572(0.79); C361(1.54); C126(1.29); C370(1.13)  LDD0573  [17]
 LDCM0257  AC138 HCT 116 C572(0.69); C361(0.97); C126(1.05); C370(0.69)  LDD0574  [17]
 LDCM0258  AC139 HCT 116 C572(1.06); C361(0.98); C126(0.78); C370(0.76)  LDD0575  [17]
 LDCM0259  AC14 HCT 116 C361(1.22); C370(0.88); C418(1.37); C528(1.18)  LDD0576  [17]
 LDCM0260  AC140 HCT 116 C572(0.53); C361(0.80); C126(0.72); C370(0.64)  LDD0577  [17]
 LDCM0261  AC141 HCT 116 C572(0.63); C361(1.12); C126(0.98); C370(0.72)  LDD0578  [17]
 LDCM0262  AC142 HCT 116 C572(1.73); C361(2.03); C126(1.37); C370(1.15)  LDD0579  [17]
 LDCM0263  AC143 HCT 116 C572(0.74); C563(0.39); C361(1.02); C126(0.74)  LDD0580  [17]
 LDCM0264  AC144 HCT 116 C563(0.21); C126(0.33); C361(0.46); C612(0.61)  LDD0581  [17]
 LDCM0265  AC145 HCT 116 C563(0.55); C572(0.71); C612(0.78); C126(0.81)  LDD0582  [17]
 LDCM0266  AC146 HCT 116 C563(0.31); C126(0.44); C572(0.59); C361(0.68)  LDD0583  [17]
 LDCM0267  AC147 HCT 116 C563(0.13); C126(0.24); C361(0.43); C572(0.61)  LDD0584  [17]
 LDCM0268  AC148 HCT 116 C563(0.15); C126(0.28); C361(0.41); C572(0.49)  LDD0585  [17]
 LDCM0269  AC149 HCT 116 C563(0.12); C126(0.26); C572(0.42); C361(0.43)  LDD0586  [17]
 LDCM0270  AC15 HCT 116 C370(0.88); C418(0.97); C612(0.98); C361(0.99)  LDD0587  [17]
 LDCM0271  AC150 HCT 116 C563(0.51); C572(0.76); C612(0.81); C361(0.87)  LDD0588  [17]
 LDCM0272  AC151 HCT 116 C126(0.74); C418(0.85); C361(0.90); C612(1.00)  LDD0589  [17]
 LDCM0273  AC152 HCT 116 C563(0.13); C126(0.30); C361(0.38); C572(0.50)  LDD0590  [17]
 LDCM0274  AC153 HCT 116 C563(0.17); C126(0.32); C361(0.40); C572(0.44)  LDD0591  [17]
 LDCM0621  AC154 HCT 116 C572(0.61); C563(0.30); C361(0.53); C126(0.37)  LDD2158  [17]
 LDCM0622  AC155 HCT 116 C572(0.55); C563(0.27); C361(0.53); C126(0.36)  LDD2159  [17]
 LDCM0623  AC156 HCT 116 C572(1.29); C563(1.63); C361(1.04); C126(0.92)  LDD2160  [17]
 LDCM0624  AC157 HCT 116 C572(1.38); C563(1.93); C361(0.98); C126(1.00)  LDD2161  [17]
 LDCM0276  AC17 HCT 116 C418(0.85); C528(0.94); C98(1.02); C126(1.06)  LDD0593  [17]
 LDCM0277  AC18 HCT 116 C563(0.23); C572(0.27); C361(0.56); C418(0.58)  LDD0594  [17]
 LDCM0278  AC19 HCT 116 C418(0.79); C361(0.86); C126(1.00); C528(1.00)  LDD0595  [17]
 LDCM0279  AC2 HCT 116 C126(0.73); C361(0.79); C612(0.98); C528(1.08)  LDD0596  [17]
 LDCM0280  AC20 HCT 116 C418(0.80); C528(0.93); C98(1.07); C370(1.10)  LDD0597  [17]
 LDCM0281  AC21 HCT 116 C418(0.80); C528(0.96); C361(0.96); C563(1.01)  LDD0598  [17]
 LDCM0282  AC22 HCT 116 C418(0.85); C528(0.93); C126(0.94); C361(1.02)  LDD0599  [17]
 LDCM0283  AC23 HCT 116 C418(0.86); C528(0.94); C370(0.95); C572(1.05)  LDD0600  [17]
 LDCM0284  AC24 HCT 116 C418(0.92); C528(0.99); C98(1.04); C370(1.06)  LDD0601  [17]
 LDCM0285  AC25 HCT 116 C528(0.72); C572(0.90); C563(0.90); C126(0.96)  LDD0602  [17]
 LDCM0286  AC26 HCT 116 C126(0.45); C572(0.65); C563(0.65); C528(0.78)  LDD0603  [17]
 LDCM0287  AC27 HCT 116 C572(0.56); C563(0.56); C126(0.72); C612(0.80)  LDD0604  [17]
 LDCM0288  AC28 HCT 116 C126(0.42); C572(0.51); C563(0.51); C528(0.77)  LDD0605  [17]
 LDCM0289  AC29 HCT 116 C126(0.57); C572(0.73); C563(0.73); C612(0.78)  LDD0606  [17]
 LDCM0290  AC3 HCT 116 C126(0.76); C361(0.89); C98(1.06); C528(1.09)  LDD0607  [17]
 LDCM0291  AC30 HCT 116 C572(0.48); C563(0.48); C126(0.59); C418(0.62)  LDD0608  [17]
 LDCM0292  AC31 HCT 116 C572(0.46); C563(0.46); C126(0.47); C612(0.78)  LDD0609  [17]
 LDCM0293  AC32 HCT 116 C572(0.15); C563(0.15); C126(0.42); C418(0.44)  LDD0610  [17]
 LDCM0294  AC33 HCT 116 C572(0.26); C563(0.26); C418(0.54); C370(0.59)  LDD0611  [17]
 LDCM0295  AC34 HCT 116 C572(0.15); C563(0.15); C418(0.43); C612(0.48)  LDD0612  [17]
 LDCM0296  AC35 HCT 116 C98(0.98); C418(1.75); C370(1.76); C612(1.96)  LDD0613  [17]
 LDCM0297  AC36 HCT 116 C98(0.60); C370(1.53); C612(1.67); C572(1.78)  LDD0614  [17]
 LDCM0298  AC37 HCT 116 C98(0.74); C370(1.42); C612(1.49); C572(1.61)  LDD0615  [17]
 LDCM0299  AC38 HCT 116 C98(0.92); C418(1.22); C572(1.36); C612(1.43)  LDD0616  [17]
 LDCM0300  AC39 HCT 116 C563(0.73); C98(0.83); C612(0.94); C572(0.95)  LDD0617  [17]
 LDCM0301  AC4 HCT 116 C126(0.95); C361(1.00); C612(1.04); C528(1.08)  LDD0618  [17]
 LDCM0302  AC40 HCT 116 C563(0.55); C572(0.77); C98(0.81); C361(0.85)  LDD0619  [17]
 LDCM0303  AC41 HCT 116 C98(0.74); C418(1.02); C572(1.10); C563(1.14)  LDD0620  [17]
 LDCM0304  AC42 HCT 116 C572(0.46); C563(0.65); C370(0.86); C612(0.90)  LDD0621  [17]
 LDCM0305  AC43 HCT 116 C98(0.84); C572(1.15); C612(1.17); C563(1.22)  LDD0622  [17]
 LDCM0306  AC44 HCT 116 C563(0.58); C572(0.81); C98(0.87); C370(0.93)  LDD0623  [17]
 LDCM0307  AC45 HCT 116 C563(0.57); C98(0.79); C370(0.79); C572(0.82)  LDD0624  [17]
 LDCM0308  AC46 HCT 116 C361(0.47); C418(0.71); C126(0.87); C370(0.89)  LDD0625  [17]
 LDCM0309  AC47 HCT 116 C361(0.60); C126(0.63); C572(0.67); C563(0.67)  LDD0626  [17]
 LDCM0310  AC48 HCT 116 C361(0.48); C126(0.71); C418(0.83); C612(0.87)  LDD0627  [17]
 LDCM0311  AC49 HCT 116 C572(0.49); C563(0.49); C361(0.55); C126(0.65)  LDD0628  [17]
 LDCM0312  AC5 HCT 116 C126(0.82); C361(0.93); C612(0.94); C98(1.09)  LDD0629  [17]
 LDCM0313  AC50 HCT 116 C361(0.48); C572(0.51); C563(0.51); C126(0.55)  LDD0630  [17]
 LDCM0314  AC51 HCT 116 C361(0.60); C418(0.77); C98(0.84); C528(1.00)  LDD0631  [17]
 LDCM0315  AC52 HCT 116 C361(0.55); C572(0.63); C563(0.63); C126(0.67)  LDD0632  [17]
 LDCM0316  AC53 HCT 116 C572(0.46); C563(0.46); C126(0.62); C612(0.68)  LDD0633  [17]
 LDCM0317  AC54 HCT 116 C572(0.50); C563(0.50); C361(0.55); C126(0.64)  LDD0634  [17]
 LDCM0318  AC55 HCT 116 C572(0.56); C563(0.56); C370(0.66); C612(0.73)  LDD0635  [17]
 LDCM0319  AC56 HCT 116 C361(0.60); C572(0.66); C563(0.66); C418(0.68)  LDD0636  [17]
 LDCM0320  AC57 HCT 116 C572(0.12); C563(0.12); C612(0.48); C418(0.67)  LDD0637  [17]
 LDCM0321  AC58 HCT 116 C572(0.12); C563(0.12); C612(0.58); C418(0.61)  LDD0638  [17]
 LDCM0322  AC59 HCT 116 C572(0.08); C563(0.08); C612(0.41); C370(0.56)  LDD0639  [17]
 LDCM0323  AC6 HCT 116 C361(0.80); C370(0.81); C418(0.83); C612(0.87)  LDD0640  [17]
 LDCM0324  AC60 HCT 116 C572(0.15); C563(0.15); C612(0.47); C361(0.71)  LDD0641  [17]
 LDCM0325  AC61 HCT 116 C572(0.18); C563(0.18); C612(0.51); C418(0.66)  LDD0642  [17]
 LDCM0326  AC62 HCT 116 C572(0.13); C563(0.13); C612(0.44); C370(0.61)  LDD0643  [17]
 LDCM0327  AC63 HCT 116 C572(0.12); C563(0.12); C612(0.52); C370(0.77)  LDD0644  [17]
 LDCM0328  AC64 HCT 116 C572(0.08); C563(0.08); C612(0.41); C370(0.60)  LDD0645  [17]
 LDCM0329  AC65 HCT 116 C572(0.07); C563(0.07); C612(0.37); C418(0.54)  LDD0646  [17]
 LDCM0330  AC66 HCT 116 C572(0.11); C563(0.11); C612(0.49); C370(0.61)  LDD0647  [17]
 LDCM0331  AC67 HCT 116 C572(0.07); C563(0.07); C612(0.36); C418(0.54)  LDD0648  [17]
 LDCM0332  AC68 HCT 116 C572(0.29); C563(0.29); C370(0.60); C612(0.64)  LDD0649  [17]
 LDCM0333  AC69 HCT 116 C572(0.37); C563(0.37); C370(0.61); C126(0.68)  LDD0650  [17]
 LDCM0334  AC7 HCT 116 C361(0.87); C612(0.90); C418(0.95); C370(0.96)  LDD0651  [17]
 LDCM0335  AC70 HCT 116 C572(0.20); C563(0.20); C612(0.52); C370(0.53)  LDD0652  [17]
 LDCM0336  AC71 HCT 116 C572(0.63); C563(0.63); C612(0.83); C370(0.87)  LDD0653  [17]
 LDCM0337  AC72 HCT 116 C572(0.26); C563(0.26); C370(0.53); C612(0.55)  LDD0654  [17]
 LDCM0338  AC73 HCT 116 C572(0.29); C563(0.29); C361(0.66); C370(0.57)  LDD0655  [17]
 LDCM0339  AC74 HCT 116 C572(0.27); C563(0.27); C370(0.64); C612(0.70)  LDD0656  [17]
 LDCM0340  AC75 HCT 116 C572(0.34); C563(0.34); C370(0.60); C361(0.61)  LDD0657  [17]
 LDCM0341  AC76 HCT 116 C572(0.21); C563(0.21); C370(0.59); C612(0.65)  LDD0658  [17]
 LDCM0342  AC77 HCT 116 C572(0.24); C563(0.24); C370(0.50); C612(0.58)  LDD0659  [17]
 LDCM0343  AC78 HCT 116 C572(0.80); C563(0.80); C528(0.91); C612(0.91)  LDD0660  [17]
 LDCM0344  AC79 HCT 116 C572(0.34); C563(0.34); C361(0.62); C370(0.62)  LDD0661  [17]
 LDCM0345  AC8 HCT 116 C370(0.80); C612(0.83); C418(0.92); C98(0.97)  LDD0662  [17]
 LDCM0346  AC80 HCT 116 C572(0.24); C563(0.24); C370(0.51); C612(0.59)  LDD0663  [17]
 LDCM0347  AC81 HCT 116 C418(0.66); C572(0.75); C563(0.75); C126(0.91)  LDD0664  [17]
 LDCM0348  AC82 HCT 116 C572(0.32); C563(0.32); C612(0.59); C370(0.74)  LDD0665  [17]
 LDCM0349  AC83 HCT 116 C572(0.11); C563(0.11); C126(0.46); C612(0.53)  LDD0666  [17]
 LDCM0350  AC84 HCT 116 C572(0.12); C563(0.12); C126(0.45); C612(0.48)  LDD0667  [17]
 LDCM0351  AC85 HCT 116 C572(0.37); C563(0.37); C361(0.59); C126(0.67)  LDD0668  [17]
 LDCM0352  AC86 HCT 116 C572(0.40); C563(0.40); C126(0.70); C370(0.70)  LDD0669  [17]
 LDCM0353  AC87 HCT 116 C572(0.67); C563(0.67); C418(0.81); C370(0.83)  LDD0670  [17]
 LDCM0354  AC88 HCT 116 C370(0.69); C418(0.72); C126(0.76); C612(0.88)  LDD0671  [17]
 LDCM0355  AC89 HCT 116 C572(0.22); C563(0.22); C126(0.45); C370(0.46)  LDD0672  [17]
 LDCM0357  AC90 HCT 116 C418(0.71); C98(0.96); C361(1.04); C528(1.13)  LDD0674  [17]
 LDCM0358  AC91 HCT 116 C572(0.12); C563(0.12); C126(0.48); C612(0.57)  LDD0675  [17]
 LDCM0359  AC92 HCT 116 C572(0.12); C563(0.12); C126(0.43); C612(0.53)  LDD0676  [17]
 LDCM0360  AC93 HCT 116 C572(0.59); C563(0.59); C126(0.66); C612(0.69)  LDD0677  [17]
 LDCM0361  AC94 HCT 116 C361(0.69); C126(0.94); C612(0.97); C98(0.98)  LDD0678  [17]
 LDCM0362  AC95 HCT 116 C572(0.39); C563(0.39); C126(0.66); C418(0.68)  LDD0679  [17]
 LDCM0363  AC96 HCT 116 C572(0.34); C563(0.34); C126(0.64); C612(0.66)  LDD0680  [17]
 LDCM0364  AC97 HCT 116 C572(0.15); C563(0.15); C126(0.44); C612(0.47)  LDD0681  [17]
 LDCM0365  AC98 HCT 116 C572(0.06); C563(0.06); C126(0.28); C612(0.39)  LDD0682  [17]
 LDCM0366  AC99 HCT 116 C612(0.67); C126(0.82); C370(0.91); C572(0.98)  LDD0683  [17]
 LDCM0166  Afatinib A431 2.21  LDD0421  [11]
 LDCM0248  AKOS034007472 HCT 116 C361(1.17); C370(1.05); C418(1.22); C528(1.09)  LDD0565  [17]
 LDCM0356  AKOS034007680 HCT 116 C370(0.89); C612(0.89); C98(1.08); C528(1.16)  LDD0673  [17]
 LDCM0275  AKOS034007705 HCT 116 C612(0.55); C98(0.62); C370(0.65); C418(0.79)  LDD0592  [17]
 LDCM0156  Aniline NCI-H1299 11.41  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C528(1.04); C98(1.03)  LDD0078  [17]
 LDCM0108  Chloroacetamide HeLa C361(0.00); C98(0.00); C528(0.00); C612(0.00)  LDD0222  [31]
 LDCM0632  CL-Sc Hep-G2 C126(0.95)  LDD2227  [25]
 LDCM0367  CL1 HCT 116 C528(0.90); C361(0.93); C98(0.93); C126(0.98)  LDD0684  [17]
 LDCM0368  CL10 HCT 116 C563(0.32); C361(0.46); C612(0.47); C126(0.49)  LDD0685  [17]
 LDCM0369  CL100 HCT 116 C361(0.79); C126(0.86); C612(0.90); C98(1.03)  LDD0686  [17]
 LDCM0370  CL101 HCT 116 C370(0.69); C612(0.82); C361(0.86); C418(0.94)  LDD0687  [17]
 LDCM0371  CL102 HCT 116 C361(0.89); C98(0.99); C418(0.99); C370(1.00)  LDD0688  [17]
 LDCM0372  CL103 HCT 116 C98(0.87); C370(1.00); C612(1.08); C528(1.10)  LDD0689  [17]
 LDCM0373  CL104 HCT 116 C361(0.87); C370(0.93); C418(0.94); C612(1.04)  LDD0690  [17]
 LDCM0374  CL105 HCT 116 C563(0.47); C572(0.52); C418(0.69); C361(0.74)  LDD0691  [17]
 LDCM0375  CL106 HCT 116 C563(0.23); C572(0.27); C361(0.61); C418(0.64)  LDD0692  [17]
 LDCM0376  CL107 HCT 116 C563(0.18); C572(0.20); C361(0.47); C418(0.54)  LDD0693  [17]
 LDCM0377  CL108 HCT 116 C563(0.18); C572(0.21); C370(0.59); C418(0.59)  LDD0694  [17]
 LDCM0378  CL109 HCT 116 C361(0.57); C418(0.58); C563(0.64); C572(0.65)  LDD0695  [17]
 LDCM0379  CL11 HCT 116 C563(0.34); C572(0.47); C612(0.50); C361(0.54)  LDD0696  [17]
 LDCM0380  CL110 HCT 116 C563(0.40); C572(0.41); C418(0.56); C361(0.76)  LDD0697  [17]
 LDCM0381  CL111 HCT 116 C418(0.58); C361(0.71); C563(0.74); C126(0.83)  LDD0698  [17]
 LDCM0382  CL112 HCT 116 C572(0.73); C563(0.73); C528(0.76); C126(0.85)  LDD0699  [17]
 LDCM0383  CL113 HCT 116 C572(0.26); C563(0.26); C418(0.58); C612(0.59)  LDD0700  [17]
 LDCM0384  CL114 HCT 116 C528(0.73); C572(0.80); C563(0.80); C612(0.80)  LDD0701  [17]
 LDCM0385  CL115 HCT 116 C572(0.63); C563(0.63); C370(0.71); C528(0.76)  LDD0702  [17]
 LDCM0386  CL116 HCT 116 C572(0.44); C563(0.44); C418(0.74); C528(0.76)  LDD0703  [17]
 LDCM0387  CL117 HCT 116 C563(0.70); C418(0.83); C572(0.91); C98(0.93)  LDD0704  [17]
 LDCM0388  CL118 HCT 116 C563(0.66); C612(0.88); C98(0.92); C572(0.94)  LDD0705  [17]
 LDCM0389  CL119 HCT 116 C563(0.68); C98(0.70); C612(0.78); C361(0.80)  LDD0706  [17]
 LDCM0390  CL12 HCT 116 C563(0.29); C126(0.40); C612(0.50); C361(0.53)  LDD0707  [17]
 LDCM0391  CL120 HCT 116 C98(0.92); C563(1.01); C612(1.06); C572(1.08)  LDD0708  [17]
 LDCM0392  CL121 HCT 116 C126(0.64); C361(0.66); C418(0.66); C370(0.67)  LDD0709  [17]
 LDCM0393  CL122 HCT 116 C361(0.58); C418(0.65); C572(0.82); C563(0.82)  LDD0710  [17]
 LDCM0394  CL123 HCT 116 C572(0.42); C563(0.42); C361(0.51); C126(0.54)  LDD0711  [17]
 LDCM0395  CL124 HCT 116 C572(0.45); C563(0.45); C361(0.56); C126(0.58)  LDD0712  [17]
 LDCM0396  CL125 HCT 116 C572(0.61); C563(0.61); C612(0.76); C126(0.77)  LDD0713  [17]
 LDCM0397  CL126 HCT 116 C572(0.51); C563(0.51); C612(0.73); C361(0.83)  LDD0714  [17]
 LDCM0398  CL127 HCT 116 C418(0.70); C126(0.73); C612(0.74); C361(0.83)  LDD0715  [17]
 LDCM0399  CL128 HCT 116 C572(0.08); C563(0.08); C612(0.41); C418(0.59)  LDD0716  [17]
 LDCM0400  CL13 HCT 116 C563(0.44); C612(0.60); C572(0.64); C361(0.65)  LDD0717  [17]
 LDCM0401  CL14 HCT 116 C612(0.65); C563(0.72); C361(0.78); C572(0.79)  LDD0718  [17]
 LDCM0402  CL15 HCT 116 C563(0.58); C572(0.72); C528(0.76); C361(0.76)  LDD0719  [17]
 LDCM0403  CL16 HCT 116 C361(0.60); C418(0.74); C370(0.79); C572(0.83)  LDD0720  [17]
 LDCM0404  CL17 HCT 116 C361(0.51); C126(0.52); C563(0.62); C572(0.72)  LDD0721  [17]
 LDCM0405  CL18 HCT 116 C361(0.28); C563(0.34); C126(0.50); C572(0.57)  LDD0722  [17]
 LDCM0406  CL19 HCT 116 C361(0.40); C563(0.54); C572(0.66); C126(0.68)  LDD0723  [17]
 LDCM0407  CL2 HCT 116 C361(0.87); C98(0.95); C528(0.98); C126(1.03)  LDD0724  [17]
 LDCM0408  CL20 HCT 116 C361(0.21); C563(0.22); C126(0.33); C572(0.52)  LDD0725  [17]
 LDCM0409  CL21 HCT 116 C361(0.17); C563(0.18); C126(0.33); C572(0.42)  LDD0726  [17]
 LDCM0410  CL22 HCT 116 C361(0.21); C563(0.23); C572(0.55); C612(0.70)  LDD0727  [17]
 LDCM0411  CL23 HCT 116 C361(0.23); C563(0.26); C572(0.48); C612(0.57)  LDD0728  [17]
 LDCM0412  CL24 HCT 116 C361(0.18); C563(0.20); C572(0.45); C126(0.43)  LDD0729  [17]
 LDCM0413  CL25 HCT 116 C572(0.39); C563(0.16); C361(0.17); C126(0.44)  LDD0730  [17]
 LDCM0414  CL26 HCT 116 C572(0.51); C563(0.32); C361(0.27); C126(0.53)  LDD0731  [17]
 LDCM0415  CL27 HCT 116 C572(0.49); C563(0.28); C361(0.29); C126(0.58)  LDD0732  [17]
 LDCM0416  CL28 HCT 116 C572(0.50); C563(0.30); C361(0.24); C126(0.42)  LDD0733  [17]
 LDCM0417  CL29 HCT 116 C572(0.51); C563(0.21); C361(0.23); C126(0.40)  LDD0734  [17]
 LDCM0418  CL3 HCT 116 C572(0.97); C563(0.95); C361(1.26); C126(0.84)  LDD0735  [17]
 LDCM0419  CL30 HCT 116 C572(0.83); C563(0.69); C361(0.49); C126(0.76)  LDD0736  [17]
 LDCM0420  CL31 HCT 116 C572(0.66); C563(0.52); C361(0.82); C126(0.80)  LDD0737  [17]
 LDCM0421  CL32 HCT 116 C572(0.25); C563(0.25); C361(0.63); C126(0.65)  LDD0738  [17]
 LDCM0422  CL33 HCT 116 C572(0.42); C563(0.42); C361(0.54); C126(0.71)  LDD0739  [17]
 LDCM0423  CL34 HCT 116 C572(0.15); C563(0.15); C361(0.37); C126(0.53)  LDD0740  [17]
 LDCM0424  CL35 HCT 116 C572(0.22); C563(0.22); C361(0.43); C126(0.62)  LDD0741  [17]
 LDCM0425  CL36 HCT 116 C572(0.20); C563(0.20); C361(0.38); C126(0.64)  LDD0742  [17]
 LDCM0426  CL37 HCT 116 C572(0.19); C563(0.19); C361(0.46); C126(0.60)  LDD0743  [17]
 LDCM0428  CL39 HCT 116 C572(0.15); C563(0.15); C361(0.49); C126(0.59)  LDD0745  [17]
 LDCM0429  CL4 HCT 116 C572(0.87); C563(0.89); C361(0.88); C126(1.00)  LDD0746  [17]
 LDCM0430  CL40 HCT 116 C572(0.18); C563(0.18); C361(0.49); C126(0.55)  LDD0747  [17]
 LDCM0431  CL41 HCT 116 C572(0.17); C563(0.17); C361(0.52); C126(0.65)  LDD0748  [17]
 LDCM0432  CL42 HCT 116 C572(0.22); C563(0.22); C361(0.59); C126(0.78)  LDD0749  [17]
 LDCM0433  CL43 HCT 116 C572(0.21); C563(0.21); C361(0.57); C126(0.66)  LDD0750  [17]
 LDCM0434  CL44 HCT 116 C572(0.28); C563(0.28); C361(0.56); C126(0.66)  LDD0751  [17]
 LDCM0435  CL45 HCT 116 C572(0.18); C563(0.18); C361(0.39); C126(0.50)  LDD0752  [17]
 LDCM0436  CL46 HCT 116 C572(4.25); C563(4.25); C361(0.57); C126(1.05)  LDD0753  [17]
 LDCM0437  CL47 HCT 116 C572(3.82); C563(3.82); C361(0.65); C126(1.19)  LDD0754  [17]
 LDCM0438  CL48 HCT 116 C572(6.15); C563(6.15); C361(0.76); C126(1.22)  LDD0755  [17]
 LDCM0439  CL49 HCT 116 C572(2.79); C563(2.79); C361(0.84); C126(1.08)  LDD0756  [17]
 LDCM0440  CL5 HCT 116 C572(0.84); C563(0.71); C361(0.81); C126(1.15)  LDD0757  [17]
 LDCM0441  CL50 HCT 116 C572(3.41); C563(3.41); C361(0.96); C126(1.27)  LDD0758  [17]
 LDCM0442  CL51 HCT 116 C572(3.14); C563(3.14); C361(0.72); C126(1.07)  LDD0759  [17]
 LDCM0443  CL52 HCT 116 C572(2.25); C563(2.25); C361(0.70); C126(0.99)  LDD0760  [17]
 LDCM0444  CL53 HCT 116 C572(4.50); C563(4.50); C361(0.76); C126(1.53)  LDD0761  [17]
 LDCM0445  CL54 HCT 116 C572(3.15); C563(3.15); C361(0.63); C126(0.95)  LDD0762  [17]
 LDCM0446  CL55 HCT 116 C572(3.19); C563(3.19); C361(0.71); C126(1.36)  LDD0763  [17]
 LDCM0447  CL56 HCT 116 C572(1.35); C563(1.35); C361(0.72); C126(1.07)  LDD0764  [17]
 LDCM0448  CL57 HCT 116 C572(3.14); C563(3.14); C361(0.75); C126(1.38)  LDD0765  [17]
 LDCM0449  CL58 HCT 116 C572(5.43); C563(5.43); C361(0.74); C126(1.15)  LDD0766  [17]
 LDCM0450  CL59 HCT 116 C572(1.59); C563(1.59); C361(0.80); C126(1.08)  LDD0767  [17]
 LDCM0451  CL6 HCT 116 C572(0.81); C563(0.69); C361(0.66); C126(0.79)  LDD0768  [17]
 LDCM0452  CL60 HCT 116 C572(2.82); C563(2.82); C361(0.69); C126(0.95)  LDD0769  [17]
 LDCM0453  CL61 HCT 116 C572(0.88); C563(0.88); C361(0.89); C126(0.63)  LDD0770  [17]
 LDCM0454  CL62 HCT 116 C572(0.80); C563(0.80); C361(0.85); C126(0.64)  LDD0771  [17]
 LDCM0455  CL63 HCT 116 C572(0.37); C563(0.37); C361(0.68); C126(0.77)  LDD0772  [17]
 LDCM0456  CL64 HCT 116 C572(0.22); C563(0.22); C361(0.50); C126(0.66)  LDD0773  [17]
 LDCM0457  CL65 HCT 116 C572(0.61); C563(0.61); C361(0.86); C126(1.09)  LDD0774  [17]
 LDCM0458  CL66 HCT 116 C572(0.12); C563(0.12); C361(0.47); C126(0.85)  LDD0775  [17]
 LDCM0459  CL67 HCT 116 C572(0.19); C563(0.19); C361(0.66); C126(1.26)  LDD0776  [17]
 LDCM0460  CL68 HCT 116 C572(0.29); C563(0.29); C361(0.65); C126(1.62)  LDD0777  [17]
 LDCM0461  CL69 HCT 116 C572(0.53); C563(0.53); C361(0.53); C126(0.64)  LDD0778  [17]
 LDCM0462  CL7 HCT 116 C572(0.61); C563(0.28); C361(0.54); C126(0.80)  LDD0779  [17]
 LDCM0463  CL70 HCT 116 C572(0.55); C563(0.55); C361(0.69); C126(0.79)  LDD0780  [17]
 LDCM0464  CL71 HCT 116 C572(0.30); C563(0.30); C361(0.69); C126(0.89)  LDD0781  [17]
 LDCM0465  CL72 HCT 116 C572(0.64); C563(0.64); C361(0.88); C126(0.71)  LDD0782  [17]
 LDCM0466  CL73 HCT 116 C572(0.39); C563(0.39); C361(0.67); C126(0.97)  LDD0783  [17]
 LDCM0467  CL74 HCT 116 C572(0.28); C563(0.28); C361(0.73); C126(1.28)  LDD0784  [17]
 LDCM0469  CL76 HCT 116 C572(0.40); C563(0.40); C361(0.76); C126(1.44)  LDD0786  [17]
 LDCM0470  CL77 HCT 116 C572(0.77); C563(0.77); C361(0.90); C126(1.78)  LDD0787  [17]
 LDCM0471  CL78 HCT 116 C572(0.40); C563(0.40); C361(0.83); C126(1.44)  LDD0788  [17]
 LDCM0472  CL79 HCT 116 C572(0.13); C563(0.13); C361(0.51); C126(1.25)  LDD0789  [17]
 LDCM0473  CL8 HCT 116 C572(0.45); C563(0.29); C361(0.49); C126(0.91)  LDD0790  [17]
 LDCM0474  CL80 HCT 116 C572(0.66); C563(0.66); C361(0.79); C126(1.20)  LDD0791  [17]
 LDCM0475  CL81 HCT 116 C572(0.30); C563(0.30); C361(0.70); C126(0.98)  LDD0792  [17]
 LDCM0476  CL82 HCT 116 C572(0.13); C563(0.13); C361(0.51); C126(1.07)  LDD0793  [17]
 LDCM0477  CL83 HCT 116 C572(0.12); C563(0.12); C361(0.45); C126(0.93)  LDD0794  [17]
 LDCM0478  CL84 HCT 116 C572(0.14); C563(0.14); C361(0.45); C126(0.90)  LDD0795  [17]
 LDCM0479  CL85 HCT 116 C572(0.34); C563(0.34); C361(0.65); C126(1.14)  LDD0796  [17]
 LDCM0480  CL86 HCT 116 C572(0.72); C563(0.72); C361(0.95); C126(1.35)  LDD0797  [17]
 LDCM0481  CL87 HCT 116 C572(0.22); C563(0.22); C361(0.66); C126(1.23)  LDD0798  [17]
 LDCM0482  CL88 HCT 116 C572(0.11); C563(0.11); C361(0.52); C126(1.71)  LDD0799  [17]
 LDCM0483  CL89 HCT 116 C572(0.17); C563(0.17); C361(0.69); C126(1.47)  LDD0800  [17]
 LDCM0484  CL9 HCT 116 C572(0.54); C563(0.43); C361(0.58); C126(0.98)  LDD0801  [17]
 LDCM0485  CL90 HCT 116 C572(1.24); C563(1.24); C361(0.98); C126(1.26)  LDD0802  [17]
 LDCM0486  CL91 HCT 116 C361(0.86); C126(0.87); C370(1.83); C528(1.09)  LDD0803  [17]
 LDCM0487  CL92 HCT 116 C361(0.96); C126(1.12); C370(1.18); C528(1.07)  LDD0804  [17]
 LDCM0488  CL93 HCT 116 C361(1.06); C126(1.20); C370(1.04); C528(0.94)  LDD0805  [17]
 LDCM0489  CL94 HCT 116 C361(0.96); C126(1.15); C370(1.14); C528(1.01)  LDD0806  [17]
 LDCM0490  CL95 HCT 116 C361(1.02); C126(1.05); C370(1.59); C528(1.05)  LDD0807  [17]
 LDCM0491  CL96 HCT 116 C361(0.91); C126(0.86); C370(1.69); C528(0.97)  LDD0808  [17]
 LDCM0492  CL97 HCT 116 C361(0.77); C126(0.81); C370(1.22); C528(1.12)  LDD0809  [17]
 LDCM0493  CL98 HCT 116 C361(0.73); C126(0.65); C370(0.90); C528(1.13)  LDD0810  [17]
 LDCM0494  CL99 HCT 116 C361(0.73); C126(0.74); C370(2.01); C528(1.15)  LDD0811  [17]
 LDCM0495  E2913 HEK-293T C98(0.91); C370(1.02); C418(0.92); C612(1.23)  LDD1698  [38]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C370(2.35); C528(1.62); C98(1.10); C361(0.89)  LDD1702  [8]
 LDCM0031  Epigallocatechin gallate HEK-293T 11.57  LDD0183  [12]
 LDCM0625  F8 Ramos C370(1.66); C612(1.18); C361(0.68); C98(1.63)  LDD2187  [39]
 LDCM0572  Fragment10 Ramos C370(0.37); C612(1.41); C361(0.58); C98(0.49)  LDD2189  [39]
 LDCM0573  Fragment11 Ramos C370(0.54); C612(0.13); C361(0.09); C98(0.12)  LDD2190  [39]
 LDCM0574  Fragment12 Ramos C370(0.60); C612(0.72); C361(0.98); C98(0.44)  LDD2191  [39]
 LDCM0575  Fragment13 Ramos C370(0.95); C612(1.01); C361(1.74); C98(0.88)  LDD2192  [39]
 LDCM0576  Fragment14 Ramos C370(0.64); C612(0.74); C361(0.77); C98(0.45)  LDD2193  [39]
 LDCM0579  Fragment20 Ramos C370(0.68); C612(0.57); C361(0.72); C98(0.36)  LDD2194  [39]
 LDCM0580  Fragment21 Ramos C370(1.01); C612(0.90); C361(1.69); C98(0.75)  LDD2195  [39]
 LDCM0582  Fragment23 Ramos C370(0.33); C612(0.64); C361(0.53); C98(0.50)  LDD2196  [39]
 LDCM0578  Fragment27 Ramos C370(0.87); C612(0.96); C361(1.61); C98(0.78)  LDD2197  [39]
 LDCM0586  Fragment28 Ramos C370(1.28); C612(0.93); C361(0.36); C98(0.65)  LDD2198  [39]
 LDCM0588  Fragment30 Ramos C370(0.93); C612(0.94); C361(1.37); C98(1.00)  LDD2199  [39]
 LDCM0589  Fragment31 Ramos C370(0.90); C612(0.93); C361(1.49); C98(0.77)  LDD2200  [39]
 LDCM0590  Fragment32 Ramos C370(0.43); C612(0.64); C361(0.85); C98(0.50)  LDD2201  [39]
 LDCM0468  Fragment33 HCT 116 C572(0.30); C563(0.30); C361(0.57); C126(0.62)  LDD0785  [17]
 LDCM0596  Fragment38 Ramos C370(0.65); C612(0.69); C361(3.22); C98(0.78)  LDD2203  [39]
 LDCM0566  Fragment4 Ramos C370(0.64); C612(3.01); C361(0.35); C98(0.70)  LDD2184  [39]
 LDCM0427  Fragment51 HCT 116 C572(0.20); C563(0.20); C361(0.47); C126(0.67)  LDD0744  [17]
 LDCM0610  Fragment52 Ramos C370(1.23); C612(0.90); C361(3.13); C98(1.08)  LDD2204  [39]
 LDCM0614  Fragment56 Ramos C370(1.34); C612(0.97); C361(1.48); C98(1.11)  LDD2205  [39]
 LDCM0569  Fragment7 Ramos C370(0.54); C612(0.50); C361(0.55); C98(0.52)  LDD2186  [39]
 LDCM0571  Fragment9 Ramos C370(0.55); C612(0.53); C361(0.84); C98(0.41)  LDD2188  [39]
 LDCM0116  HHS-0101 DM93 Y473(0.79); Y403(0.84); Y452(0.86); Y517(0.93)  LDD0264  [15]
 LDCM0117  HHS-0201 DM93 Y308(0.61); Y517(0.62); Y473(0.68); Y403(0.87)  LDD0265  [15]
 LDCM0118  HHS-0301 DM93 Y473(0.65); Y403(0.68); Y308(0.71); Y517(0.92)  LDD0266  [15]
 LDCM0119  HHS-0401 DM93 Y308(0.55); Y473(0.65); Y403(0.73); Y517(0.74)  LDD0267  [15]
 LDCM0120  HHS-0701 DM93 Y473(0.52); Y308(0.74); Y517(0.91); Y452(0.98)  LDD0268  [15]
 LDCM0107  IAA HeLa H35(0.00); H320(0.00); C361(0.00); C98(0.00)  LDD0221  [31]
 LDCM0124  JWB142 DM93 Y403(0.32); Y517(0.05)  LDD0286  [14]
 LDCM0125  JWB146 DM93 Y403(0.71); Y517(0.45)  LDD0287  [14]
 LDCM0126  JWB150 DM93 Y403(0.46); Y517(2.72)  LDD0288  [14]
 LDCM0127  JWB152 DM93 Y403(0.79); Y517(0.16)  LDD0289  [14]
 LDCM0128  JWB198 DM93 Y517(0.05)  LDD0290  [14]
 LDCM0129  JWB202 DM93 Y403(0.53); Y517(0.05)  LDD0291  [14]
 LDCM0130  JWB211 DM93 Y403(0.74); Y517(0.05)  LDD0292  [14]
 LDCM0022  KB02 HCT 116 C370(1.49); C528(1.17); C98(1.10); C612(1.14)  LDD0080  [17]
 LDCM0023  KB03 HCT 116 C370(1.20); C528(1.20); C98(1.12); C612(1.22)  LDD0081  [17]
 LDCM0024  KB05 HCT 116 C370(1.65); C528(1.13); C98(0.97); C612(0.95)  LDD0082  [17]
 LDCM0109  NEM HeLa H181(0.00); H35(0.00); H320(0.00); H143(0.00)  LDD0223  [31]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C370(1.56)  LDD2099  [8]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C370(1.11)  LDD2107  [8]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C370(1.14)  LDD2137  [8]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C370(1.11)  LDD2140  [8]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C370(1.11)  LDD2144  [8]
 LDCM0628  OTUB2-COV-1 HEK-293T C612(0.89)  LDD2207  [40]
 LDCM0131  RA190 MM1.R C612(1.00)  LDD0304  [41]
 LDCM0021  THZ1 HCT 116 C98(1.00); C418(0.98)  LDD2173  [17]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Elongation factor 1-alpha 1 (EEF1A1) Classic translation factor GTPase family P68104
Elongation factor 1-alpha 2 (EEF1A2) Classic translation factor GTPase family Q05639
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein FAM222B (FAM222B) FAM222 family Q8WU58
DnaJ homolog subfamily B member 1 (DNAJB1) . P25685
Proline-rich protein 35 (PRR35) . P0CG20

References

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2 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
3 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
4 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
5 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
6 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
7 Global profiling of lysine reactivity and ligandability in the human proteome. Nat Chem. 2017 Dec;9(12):1181-1190. doi: 10.1038/nchem.2826. Epub 2017 Jul 31.
8 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
9 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
10 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
11 Minimalist linkers suitable for irreversible inhibitors in simultaneous proteome profiling, live-cell imaging and drug screening. Chem Commun (Camb). 2019 Jan 15;55(6):834-837. doi: 10.1039/c8cc08685k.
12 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
13 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
14 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
15 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
16 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
17 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
18 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
19 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
20 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
21 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
22 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
23 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
24 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
25 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
26 Direct Target Site Identification of a Sulfonyl-Triazole Covalent Kinase Probe by LC-MS Chemical Proteomics. Anal Chem. 2021 Sep 7;93(35):11946-11955. doi: 10.1021/acs.analchem.1c01591. Epub 2021 Aug 25.
27 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
28 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
29 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
30 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
31 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
32 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
33 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
34 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
35 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
36 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
37 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
38 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
39 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
40 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
41 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.