Details of the Target

General Information of Target

Target ID LDTP03493
Target Name Serpin B3 (SERPINB3)
Gene Name SERPINB3
Gene ID 6317
Synonyms
SCCA; SCCA1; Serpin B3; Protein T4-A; Squamous cell carcinoma antigen 1; SCCA-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNSLSEANTKFMFDLFQQFRKSKENNIFYSPISITSALGMVLLGAKDNTAQQIKKVLHFD
QVTENTTGKAATYHVDRSGNVHHQFQKLLTEFNKSTDAYELKIANKLFGEKTYLFLQEYL
DAIKKFYQTSVESVDFANAPEESRKKINSWVESQTNEKIKNLIPEGNIGSNTTLVLVNAI
YFKGQWEKKFNKEDTKEEKFWPNKNTYKSIQMMRQYTSFHFASLEDVQAKVLEIPYKGKD
LSMIVLLPNEIDGLQKLEEKLTAEKLMEWTSLQNMRETRVDLHLPRFKVEESYDLKDTLR
TMGMVDIFNGDADLSGMTGSRGLVLSGVLHKAFVEVTEEGAEAAAATAVVGFGSSPTSTN
EEFHCNHPFLFFIRQNKTNSILFYGRFSSP
Target Bioclass
Other
Family
Serpin family, Ov-serpin subfamily
Subcellular location
Cytoplasm
Function
May act as a papain-like cysteine protease inhibitor to modulate the host immune response against tumor cells. Also functions as an inhibitor of UV-induced apoptosis via suppression of the activity of c-Jun NH(2)-terminal kinase (JNK1).
Uniprot ID
P29508
Ensemble ID
ENST00000283752.10
HGNC ID
HGNC:10569

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CHL1 SNV: p.G340R .
HCT15 SNV: p.K183N .
HS839T SNV: p.G303E .
HT SNV: p.V231A; p.H367R .
IGR1 SNV: p.E250K; p.S354L .
MCC13 SNV: p.E198K
Substitution: p.V134T		 .
MDAMB436 Substitution: p.V134T .
MELJUSO SNV: p.G109E .
NCIH1650 Substitution: p.V134T .
NCIH1793 SNV: p.K296T .
NCIH2286 SNV: p.N65K .
OAW42 SNV: p.G303R .
RPMI7951 SNV: p.D121Y .
SAOS2 SNV: p.T359N .
SF295 Substitution: p.V134T .

Probe(s) Labeling This Target

PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe12
 Probe Info  		20.00  LDD0474  [1]
FFF probe15
 Probe Info  		20.00  LDD0478  [1]
STS-1
 Probe Info  		N.A.  LDD0137  [2]
SAHA-CA-8PAP
 Probe Info  		N.A.  LDD0362  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0096  SAHA K562 N.A.  LDD0362  [3]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
D-serine Small molecular drug DB03929
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Dexfosfoserine Small molecular drug DB04522

References

1 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
2 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
3 Streamlined Target Deconvolution Approach Utilizing a Single Photoreactive Chloroalkane Capture Tag. ACS Chem Biol. 2021 Feb 19;16(2):404-413. doi: 10.1021/acschembio.0c00987. Epub 2021 Feb 5.