Details of the Target

General Information of Target

Target ID LDTP10069
Target Name Exocyst complex component 4 (EXOC4)
Gene Name EXOC4
Gene ID 60412
Synonyms
KIAA1699; SEC8; SEC8L1; Exocyst complex component 4; Exocyst complex component Sec8
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAGYATTPSPMQTLQEEAVCAICLDYFKDPVSISCGHNFCRGCVTQLWSKEDEEDQNEEE
DEWEEEEDEEAVGAMDGWDGSIREVLYRGNADEELFQDQDDDELWLGDSGITNWDNVDYM
WDEEEEEEEEDQDYYLGGLRPDLRIDVYREEEILEAYDEDEDEELYPDIHPPPSLPLPGQ
FTCPQCRKSFTRRSFRPNLQLANMVQIIRQMCPTPYRGNRSNDQGMCFKHQEALKLFCEV
DKEAICVVCRESRSHKQHSVLPLEEVVQEYQEIKLETTLVGILQIEQESIHSKAYNQ
Target Bioclass
Transporter and channel
Family
SEC8 family
Subcellular location
Midbody, Midbody ring
Function Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Uniprot ID
Q96A65
Ensemble ID
ENST00000253861.5
HGNC ID
HGNC:30389

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.A800D DBIA    Probe Info 
CCK81 SNV: p.N259H DBIA    Probe Info 
DU145 SNV: p.K836E .
HCT15 SNV: p.S183N DBIA    Probe Info 
KYSE410 SNV: p.P750L DBIA    Probe Info 
LS180 SNV: p.S705G DBIA    Probe Info 
LU65 SNV: p.D643N DBIA    Probe Info 
MEWO SNV: p.P293S DBIA    Probe Info 
NCIH82 Deletion: p.V367SfsTer14 .
NUGC3 SNV: p.R624M .
SG231 SNV: p.L242F .
SKMEL2 Deletion: p.P751QfsTer32 .
SNGM SNV: p.E445K DBIA    Probe Info 
SNU869 SNV: p.A427S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 18 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K16(10.00); K18(10.00); K431(10.00); K490(1.10)  LDD0277  [1]
Probe 1
 Probe Info  		Y323(12.91); Y418(13.83)  LDD3495  [2]
BTD
 Probe Info  		C957(1.11)  LDD2099  [3]
AHL-Pu-1
 Probe Info  		C957(3.23)  LDD0168  [4]
HHS-475
 Probe Info  		Y247(0.88)  LDD0264  [5]
Acrolein
 Probe Info  		N.A.  LDD0225  [6]
DBIA
 Probe Info  		C957(1.14)  LDD0078  [7]
ATP probe
 Probe Info  		N.A.  LDD0199  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		C54(0.00); C619(0.00); C957(0.00); C144(0.00)  LDD0038  [9]
IA-alkyne
 Probe Info  		C957(0.00); C489(0.00)  LDD0036  [9]
Lodoacetamide azide
 Probe Info  		C619(0.00); C957(0.00); C144(0.00); C54(0.00)  LDD0037  [9]
WYneN
 Probe Info  		C619(0.00); C957(0.00)  LDD0021  [10]
IPM
 Probe Info  		C957(0.00); C144(0.00)  LDD0005  [10]
TFBX
 Probe Info  		C489(0.00); C957(0.00); C100(0.00); C106(0.00)  LDD0148  [11]
VSF
 Probe Info  		C144(0.00); C957(0.00)  LDD0007  [10]
W1
 Probe Info  		N.A.  LDD0236  [12]
NAIA_5
 Probe Info  		C54(0.00); C957(0.00); C619(0.00); C106(0.00)  LDD2223  [13]
HHS-482
 Probe Info  		Y247(0.63)  LDD2239  [14]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		10.01  LDD0472  [15]
FFF probe12
 Probe Info  		20.00  LDD0473  [15]
FFF probe13
 Probe Info  		8.34  LDD0476  [15]
VE-P
 Probe Info  		N.A.  LDD0396  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C144(1.00)  LDD2117  [3]
 LDCM0025  4SU-RNA HEK-293T C957(3.23)  LDD0168  [4]
 LDCM0026  4SU-RNA+native RNA HEK-293T C957(4.59)  LDD0169  [4]
 LDCM0214  AC1 HCT 116 C144(0.95)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C144(0.92)  LDD0532  [7]
 LDCM0216  AC100 HEK-293T C144(1.72); C619(0.77); C957(0.94)  LDD0814  [7]
 LDCM0217  AC101 HEK-293T C144(1.58); C619(0.67); C957(0.98)  LDD0815  [7]
 LDCM0218  AC102 HEK-293T C144(1.23); C619(0.90); C957(0.99)  LDD0816  [7]
 LDCM0219  AC103 HEK-293T C144(1.35); C619(0.68); C957(1.02)  LDD0817  [7]
 LDCM0220  AC104 HEK-293T C144(1.32); C619(0.88); C957(0.93)  LDD0818  [7]
 LDCM0221  AC105 HEK-293T C144(1.19); C619(0.92); C957(0.82)  LDD0819  [7]
 LDCM0222  AC106 HEK-293T C144(0.86); C619(1.05); C957(1.09)  LDD0820  [7]
 LDCM0223  AC107 HEK-293T C144(0.92); C619(0.89); C957(0.92)  LDD0821  [7]
 LDCM0224  AC108 HEK-293T C144(1.44); C619(0.96); C957(1.05)  LDD0822  [7]
 LDCM0225  AC109 HEK-293T C144(1.24); C619(1.00); C957(0.89)  LDD0823  [7]
 LDCM0226  AC11 HCT 116 C144(0.90)  LDD0543  [7]
 LDCM0227  AC110 HEK-293T C144(1.88); C619(0.94); C957(1.01)  LDD0825  [7]
 LDCM0228  AC111 HEK-293T C144(1.86); C619(0.90); C957(1.06)  LDD0826  [7]
 LDCM0229  AC112 HEK-293T C144(1.68); C619(0.89); C957(1.05)  LDD0827  [7]
 LDCM0230  AC113 HEK-293T C144(0.98); C619(0.71)  LDD0828  [7]
 LDCM0231  AC114 HEK-293T C144(0.89); C619(0.78)  LDD0829  [7]
 LDCM0232  AC115 HEK-293T C144(1.04); C619(0.85)  LDD0830  [7]
 LDCM0233  AC116 HEK-293T C144(1.05); C619(0.85)  LDD0831  [7]
 LDCM0234  AC117 HEK-293T C144(0.97); C619(0.91)  LDD0832  [7]
 LDCM0235  AC118 HEK-293T C144(1.07); C619(0.79)  LDD0833  [7]
 LDCM0236  AC119 HEK-293T C144(1.18); C619(0.71)  LDD0834  [7]
 LDCM0237  AC12 HCT 116 C144(0.77)  LDD0554  [7]
 LDCM0238  AC120 HEK-293T C144(0.91); C619(1.09)  LDD0836  [7]
 LDCM0239  AC121 HEK-293T C144(1.31); C619(0.79)  LDD0837  [7]
 LDCM0240  AC122 HEK-293T C144(1.27); C619(0.73)  LDD0838  [7]
 LDCM0241  AC123 HEK-293T C144(1.39); C619(0.91)  LDD0839  [7]
 LDCM0242  AC124 HEK-293T C144(0.98); C619(0.87)  LDD0840  [7]
 LDCM0243  AC125 HEK-293T C144(1.09); C619(0.86)  LDD0841  [7]
 LDCM0244  AC126 HEK-293T C144(1.02); C619(0.88)  LDD0842  [7]
 LDCM0245  AC127 HEK-293T C144(1.48); C619(1.34)  LDD0843  [7]
 LDCM0246  AC128 HEK-293T C144(0.84); C619(1.44)  LDD0844  [7]
 LDCM0247  AC129 HEK-293T C144(0.87); C619(1.00)  LDD0845  [7]
 LDCM0249  AC130 HEK-293T C144(0.75); C619(1.24)  LDD0847  [7]
 LDCM0250  AC131 HEK-293T C144(0.89); C619(0.85)  LDD0848  [7]
 LDCM0251  AC132 HEK-293T C144(0.81); C619(1.19)  LDD0849  [7]
 LDCM0252  AC133 HEK-293T C144(0.90); C619(1.33)  LDD0850  [7]
 LDCM0253  AC134 HEK-293T C144(1.00); C619(1.05)  LDD0851  [7]
 LDCM0254  AC135 HEK-293T C144(1.15); C619(1.09)  LDD0852  [7]
 LDCM0255  AC136 HEK-293T C144(1.15); C619(0.90)  LDD0853  [7]
 LDCM0256  AC137 HEK-293T C144(0.95); C619(1.31)  LDD0854  [7]
 LDCM0257  AC138 HEK-293T C144(0.95); C619(1.21)  LDD0855  [7]
 LDCM0258  AC139 HEK-293T C144(0.81); C619(1.21)  LDD0856  [7]
 LDCM0259  AC14 HCT 116 C144(0.87)  LDD0576  [7]
 LDCM0260  AC140 HEK-293T C144(0.89); C619(1.11)  LDD0858  [7]
 LDCM0261  AC141 HEK-293T C144(1.05); C619(1.12)  LDD0859  [7]
 LDCM0262  AC142 HEK-293T C144(1.06); C619(1.39)  LDD0860  [7]
 LDCM0263  AC143 HEK-293T C619(0.88)  LDD0861  [7]
 LDCM0264  AC144 HEK-293T C619(1.10)  LDD0862  [7]
 LDCM0265  AC145 HEK-293T C619(1.27)  LDD0863  [7]
 LDCM0266  AC146 HEK-293T C619(1.01)  LDD0864  [7]
 LDCM0267  AC147 HEK-293T C619(0.98)  LDD0865  [7]
 LDCM0268  AC148 HEK-293T C619(1.09)  LDD0866  [7]
 LDCM0269  AC149 HEK-293T C619(1.21)  LDD0867  [7]
 LDCM0270  AC15 HCT 116 C144(1.05)  LDD0587  [7]
 LDCM0271  AC150 HEK-293T C619(1.07)  LDD0869  [7]
 LDCM0272  AC151 HEK-293T C619(1.32)  LDD0870  [7]
 LDCM0273  AC152 HEK-293T C619(1.15)  LDD0871  [7]
 LDCM0274  AC153 HEK-293T C619(1.22)  LDD0872  [7]
 LDCM0621  AC154 HEK-293T C619(1.16)  LDD2162  [7]
 LDCM0622  AC155 HEK-293T C619(1.26)  LDD2163  [7]
 LDCM0623  AC156 HEK-293T C619(1.23)  LDD2164  [7]
 LDCM0624  AC157 HEK-293T C619(1.09)  LDD2165  [7]
 LDCM0276  AC17 HCT 116 C144(1.03)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C144(0.74)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C144(0.63)  LDD0595  [7]
 LDCM0279  AC2 HCT 116 C144(1.34)  LDD0596  [7]
 LDCM0280  AC20 HCT 116 C144(0.98)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C144(0.92)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C144(0.94)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C144(0.79)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C144(0.90)  LDD0601  [7]
 LDCM0285  AC25 HEK-293T C144(0.86)  LDD0883  [7]
 LDCM0286  AC26 HEK-293T C144(1.07)  LDD0884  [7]
 LDCM0287  AC27 HEK-293T C144(1.18)  LDD0885  [7]
 LDCM0288  AC28 HEK-293T C144(0.69)  LDD0886  [7]
 LDCM0289  AC29 HEK-293T C144(0.95)  LDD0887  [7]
 LDCM0290  AC3 HCT 116 C144(1.41)  LDD0607  [7]
 LDCM0291  AC30 HEK-293T C144(0.84)  LDD0889  [7]
 LDCM0292  AC31 HEK-293T C144(0.77)  LDD0890  [7]
 LDCM0293  AC32 HEK-293T C144(1.11)  LDD0891  [7]
 LDCM0294  AC33 HEK-293T C144(1.36)  LDD0892  [7]
 LDCM0295  AC34 HEK-293T C144(0.79)  LDD0893  [7]
 LDCM0296  AC35 HCT 116 C144(1.00)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C144(0.96)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C144(0.90)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C144(1.10)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C144(1.18)  LDD0617  [7]
 LDCM0301  AC4 HCT 116 C144(1.63)  LDD0618  [7]
 LDCM0302  AC40 HCT 116 C144(1.71)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C144(0.97)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C144(1.13)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C144(1.16)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C144(1.15)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C144(1.23)  LDD0624  [7]
 LDCM0308  AC46 HEK-293T C144(0.96)  LDD0906  [7]
 LDCM0309  AC47 HEK-293T C144(1.00)  LDD0907  [7]
 LDCM0310  AC48 HEK-293T C144(1.08)  LDD0908  [7]
 LDCM0311  AC49 HEK-293T C144(1.10)  LDD0909  [7]
 LDCM0312  AC5 HCT 116 C144(1.42)  LDD0629  [7]
 LDCM0313  AC50 HEK-293T C144(1.12)  LDD0911  [7]
 LDCM0314  AC51 HEK-293T C144(1.35)  LDD0912  [7]
 LDCM0315  AC52 HEK-293T C144(1.30)  LDD0913  [7]
 LDCM0316  AC53 HEK-293T C144(1.19)  LDD0914  [7]
 LDCM0317  AC54 HEK-293T C144(1.19)  LDD0915  [7]
 LDCM0318  AC55 HEK-293T C144(1.04)  LDD0916  [7]
 LDCM0319  AC56 HEK-293T C144(1.13)  LDD0917  [7]
 LDCM0320  AC57 HEK-293T C144(0.99); C619(1.35)  LDD0918  [7]
 LDCM0321  AC58 HEK-293T C144(1.09); C619(1.11)  LDD0919  [7]
 LDCM0322  AC59 HEK-293T C144(0.95); C619(1.19)  LDD0920  [7]
 LDCM0323  AC6 HCT 116 C144(1.74)  LDD0640  [7]
 LDCM0324  AC60 HEK-293T C144(1.00); C619(0.92)  LDD0922  [7]
 LDCM0325  AC61 HEK-293T C144(1.36); C619(1.07)  LDD0923  [7]
 LDCM0326  AC62 HEK-293T C144(1.00); C619(0.95)  LDD0924  [7]
 LDCM0327  AC63 HEK-293T C144(1.03); C619(1.22)  LDD0925  [7]
 LDCM0328  AC64 HEK-293T C144(0.86); C619(1.21)  LDD0926  [7]
 LDCM0329  AC65 HEK-293T C144(1.00); C619(1.14)  LDD0927  [7]
 LDCM0330  AC66 HEK-293T C144(0.91); C619(1.35)  LDD0928  [7]
 LDCM0331  AC67 HEK-293T C144(1.11); C619(1.02)  LDD0929  [7]
 LDCM0332  AC68 HCT 116 C957(0.77)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C957(0.74)  LDD0650  [7]
 LDCM0334  AC7 HCT 116 C144(1.38)  LDD0651  [7]
 LDCM0335  AC70 HCT 116 C957(0.81)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C957(0.79)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C957(0.85)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C957(0.97)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C957(0.93)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C957(0.82)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C957(0.82)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C957(0.86)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C957(0.87)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C957(0.95)  LDD0661  [7]
 LDCM0345  AC8 HCT 116 C144(1.30)  LDD0662  [7]
 LDCM0346  AC80 HCT 116 C957(1.02)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C957(0.84)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C957(0.83)  LDD0665  [7]
 LDCM0349  AC83 HEK-293T C144(0.85); C619(1.29); C957(0.66)  LDD0947  [7]
 LDCM0350  AC84 HEK-293T C144(1.26); C619(1.08); C957(0.61)  LDD0948  [7]
 LDCM0351  AC85 HEK-293T C144(1.10); C619(1.06); C957(0.47)  LDD0949  [7]
 LDCM0352  AC86 HEK-293T C144(1.14); C619(1.13); C957(0.60)  LDD0950  [7]
 LDCM0353  AC87 HEK-293T C144(1.25); C619(1.49); C957(0.78)  LDD0951  [7]
 LDCM0354  AC88 HEK-293T C144(1.32); C619(1.26); C957(0.83)  LDD0952  [7]
 LDCM0355  AC89 HEK-293T C144(1.30); C619(1.26); C957(0.87)  LDD0953  [7]
 LDCM0357  AC90 HEK-293T C144(1.18); C619(1.19); C957(0.60)  LDD0955  [7]
 LDCM0358  AC91 HEK-293T C144(1.04); C619(1.22); C957(0.67)  LDD0956  [7]
 LDCM0359  AC92 HEK-293T C144(1.06); C619(1.42); C957(0.59)  LDD0957  [7]
 LDCM0360  AC93 HEK-293T C144(1.36); C619(1.18); C957(1.11)  LDD0958  [7]
 LDCM0361  AC94 HEK-293T C144(1.12); C619(1.21); C957(0.61)  LDD0959  [7]
 LDCM0362  AC95 HEK-293T C144(1.20); C619(1.17); C957(0.52)  LDD0960  [7]
 LDCM0363  AC96 HEK-293T C144(1.20); C619(1.63); C957(1.06)  LDD0961  [7]
 LDCM0364  AC97 HEK-293T C144(1.64); C619(1.30); C957(0.88)  LDD0962  [7]
 LDCM0365  AC98 HEK-293T C144(0.85); C619(0.81); C957(0.99)  LDD0963  [7]
 LDCM0366  AC99 HEK-293T C144(0.97); C619(0.75); C957(0.88)  LDD0964  [7]
 LDCM0248  AKOS034007472 HCT 116 C144(0.84)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C144(0.82)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C144(0.81)  LDD0592  [7]
 LDCM0020  ARS-1620 HCC44 C957(1.14)  LDD0078  [7]
 LDCM0632  CL-Sc Hep-G2 C957(1.31); C957(0.92)  LDD2227  [13]
 LDCM0367  CL1 HCT 116 C957(1.06)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C957(1.02)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C144(1.43)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C144(1.47)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C144(1.46)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C144(0.85)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C144(0.91)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C144(1.19)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C144(1.11)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C144(1.41)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C144(1.60)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C144(0.74)  LDD0695  [7]
 LDCM0379  CL11 HCT 116 C957(0.81)  LDD0696  [7]
 LDCM0380  CL110 HCT 116 C144(0.95)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C144(1.00)  LDD0698  [7]
 LDCM0382  CL112 HEK-293T C144(0.95)  LDD0980  [7]
 LDCM0383  CL113 HEK-293T C144(0.96)  LDD0981  [7]
 LDCM0384  CL114 HEK-293T C144(1.36)  LDD0982  [7]
 LDCM0385  CL115 HEK-293T C144(0.97)  LDD0983  [7]
 LDCM0386  CL116 HEK-293T C144(1.15)  LDD0984  [7]
 LDCM0387  CL117 HCT 116 C144(1.66)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C144(1.22)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C144(1.30)  LDD0706  [7]
 LDCM0390  CL12 HCT 116 C957(1.00)  LDD0707  [7]
 LDCM0391  CL120 HCT 116 C144(1.11)  LDD0708  [7]
 LDCM0392  CL121 HEK-293T C144(1.11)  LDD0990  [7]
 LDCM0393  CL122 HEK-293T C144(1.15)  LDD0991  [7]
 LDCM0394  CL123 HEK-293T C144(1.30)  LDD0992  [7]
 LDCM0395  CL124 HEK-293T C144(1.33)  LDD0993  [7]
 LDCM0396  CL125 HEK-293T C144(1.21); C619(1.11)  LDD0994  [7]
 LDCM0397  CL126 HEK-293T C144(1.42); C619(1.10)  LDD0995  [7]
 LDCM0398  CL127 HEK-293T C144(1.06); C619(1.18)  LDD0996  [7]
 LDCM0399  CL128 HEK-293T C144(0.76); C619(1.13)  LDD0997  [7]
 LDCM0400  CL13 HCT 116 C957(0.98)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C957(1.01)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C957(0.95)  LDD0719  [7]
 LDCM0403  CL16 HEK-293T C144(0.93); C619(0.70)  LDD1001  [7]
 LDCM0404  CL17 HEK-293T C144(1.26); C619(0.73)  LDD1002  [7]
 LDCM0405  CL18 HEK-293T C144(1.03); C619(0.58)  LDD1003  [7]
 LDCM0406  CL19 HEK-293T C144(1.16); C619(0.71)  LDD1004  [7]
 LDCM0407  CL2 HCT 116 C957(0.91)  LDD0724  [7]
 LDCM0408  CL20 HEK-293T C144(0.99); C619(0.87)  LDD1006  [7]
 LDCM0409  CL21 HEK-293T C144(1.49); C619(1.18)  LDD1007  [7]
 LDCM0410  CL22 HEK-293T C144(1.03); C619(1.07)  LDD1008  [7]
 LDCM0411  CL23 HEK-293T C144(1.01); C619(0.93)  LDD1009  [7]
 LDCM0412  CL24 HEK-293T C144(0.93); C619(0.86)  LDD1010  [7]
 LDCM0413  CL25 HEK-293T C144(1.03); C619(0.59)  LDD1011  [7]
 LDCM0414  CL26 HEK-293T C144(0.95); C619(0.60)  LDD1012  [7]
 LDCM0415  CL27 HEK-293T C144(1.07); C619(0.71)  LDD1013  [7]
 LDCM0416  CL28 HEK-293T C144(1.11); C619(20.00)  LDD1014  [7]
 LDCM0417  CL29 HEK-293T C144(0.99); C619(0.77)  LDD1015  [7]
 LDCM0418  CL3 HCT 116 C957(0.84)  LDD0735  [7]
 LDCM0419  CL30 HEK-293T C144(1.20); C619(1.02)  LDD1017  [7]
 LDCM0420  CL31 HCT 116 C144(1.15)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C144(1.22)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C144(0.94)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C144(1.08)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C144(1.18)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C144(1.11)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C144(1.20)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C144(1.28)  LDD0745  [7]
 LDCM0429  CL4 HCT 116 C957(1.19)  LDD0746  [7]
 LDCM0430  CL40 HCT 116 C144(1.08)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C144(1.30)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C144(1.17)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C144(1.55)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C144(1.24)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C144(1.63)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C957(1.10)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C957(1.03)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C957(0.91)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C957(0.92)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C957(0.94)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C957(0.87)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C957(0.99)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C957(1.04)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C957(1.01)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C957(1.02)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C957(0.98)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C957(1.08)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C957(0.94)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C957(0.97)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C957(1.00)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C957(0.87)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C957(0.97)  LDD0769  [7]
 LDCM0453  CL61 HCT 116 C957(1.18)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C957(1.08)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C957(1.07)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C957(1.23)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C957(0.95)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C957(1.18)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C957(1.02)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C957(1.08)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C957(1.20)  LDD0778  [7]
 LDCM0462  CL7 HCT 116 C957(0.97)  LDD0779  [7]
 LDCM0463  CL70 HCT 116 C957(1.05)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C957(1.12)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C957(1.32)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C957(1.02)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C957(1.07)  LDD0784  [7]
 LDCM0469  CL76 HEK-293T C144(0.85); C619(0.92)  LDD1067  [7]
 LDCM0470  CL77 HEK-293T C144(1.11); C619(0.62)  LDD1068  [7]
 LDCM0471  CL78 HEK-293T C144(0.70); C619(0.58)  LDD1069  [7]
 LDCM0472  CL79 HEK-293T C144(0.88); C619(0.64)  LDD1070  [7]
 LDCM0473  CL8 HCT 116 C957(0.98)  LDD0790  [7]
 LDCM0474  CL80 HEK-293T C144(0.79); C619(1.22)  LDD1072  [7]
 LDCM0475  CL81 HEK-293T C144(1.07); C619(0.97)  LDD1073  [7]
 LDCM0476  CL82 HEK-293T C144(1.21); C619(0.80)  LDD1074  [7]
 LDCM0477  CL83 HEK-293T C144(1.32); C619(0.81)  LDD1075  [7]
 LDCM0478  CL84 HEK-293T C144(0.90); C619(0.73)  LDD1076  [7]
 LDCM0479  CL85 HEK-293T C144(0.84); C619(0.64)  LDD1077  [7]
 LDCM0480  CL86 HEK-293T C144(0.68); C619(0.98)  LDD1078  [7]
 LDCM0481  CL87 HEK-293T C144(0.81); C619(0.84)  LDD1079  [7]
 LDCM0482  CL88 HEK-293T C144(0.94); C619(1.17)  LDD1080  [7]
 LDCM0483  CL89 HEK-293T C144(0.76); C619(0.79)  LDD1081  [7]
 LDCM0484  CL9 HCT 116 C957(0.99)  LDD0801  [7]
 LDCM0485  CL90 HEK-293T C144(1.71); C619(0.83)  LDD1083  [7]
 LDCM0486  CL91 HCT 116 C144(0.92)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C144(0.66)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C144(0.99)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C144(1.02)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C144(1.22)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C144(0.99)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C144(1.28)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C144(1.11)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C144(1.24)  LDD0811  [7]
 LDCM0495  E2913 HEK-293T C619(0.94); C144(1.00); C100(1.17); C957(1.01)  LDD1698  [17]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C106(1.39); C489(0.92)  LDD1702  [3]
 LDCM0625  F8 Ramos C489(1.19); C957(0.99)  LDD2187  [18]
 LDCM0572  Fragment10 Ramos C489(2.40)  LDD2189  [18]
 LDCM0573  Fragment11 Ramos C489(0.17); C957(1.81)  LDD2190  [18]
 LDCM0576  Fragment14 Ramos C489(1.06); C957(0.95)  LDD2193  [18]
 LDCM0580  Fragment21 Ramos C489(0.60)  LDD2195  [18]
 LDCM0582  Fragment23 Ramos C489(0.93)  LDD2196  [18]
 LDCM0586  Fragment28 Ramos C489(0.91)  LDD2198  [18]
 LDCM0588  Fragment30 Ramos C489(1.14); C957(12.97)  LDD2199  [18]
 LDCM0468  Fragment33 HCT 116 C957(1.12)  LDD0785  [7]
 LDCM0427  Fragment51 HCT 116 C144(1.46)  LDD0744  [7]
 LDCM0610  Fragment52 Ramos C957(7.10)  LDD2204  [18]
 LDCM0614  Fragment56 Ramos C957(3.95)  LDD2205  [18]
 LDCM0569  Fragment7 Ramos C489(1.81); C957(0.90)  LDD2186  [18]
 LDCM0116  HHS-0101 DM93 Y247(0.88)  LDD0264  [5]
 LDCM0117  HHS-0201 DM93 Y247(0.70)  LDD0265  [5]
 LDCM0118  HHS-0301 DM93 Y247(0.91)  LDD0266  [5]
 LDCM0119  HHS-0401 DM93 Y247(1.24)  LDD0267  [5]
 LDCM0120  HHS-0701 DM93 Y247(1.65)  LDD0268  [5]
 LDCM0022  KB02 HCT 116 C144(2.46); C957(1.27)  LDD0080  [7]
 LDCM0023  KB03 HCT 116 C144(2.83); C957(1.11)  LDD0081  [7]
 LDCM0024  KB05 HCT 116 C144(2.43); C957(1.22)  LDD0082  [7]
 LDCM0109  NEM HeLa N.A.  LDD0225  [6]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C957(1.11)  LDD2099  [3]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C144(0.79)  LDD2109  [3]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C144(0.93)  LDD2123  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C144(0.80)  LDD2125  [3]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C144(1.10)  LDD2127  [3]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C144(1.23)  LDD2136  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C144(1.03)  LDD2137  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C144(0.85)  LDD2140  [3]
 LDCM0021  THZ1 HCT 116 C619(0.91)  LDD2173  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Epidermal growth factor receptor (EGFR) Tyr protein kinase family P00533
Myotubularin (MTM1) Protein-tyrosine phosphatase family Q13496
Baculoviral IAP repeat-containing protein 6 (BIRC6) Ubiquitin-conjugating enzyme family Q9NR09
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Exocyst complex component 8 (EXOC8) EXO84 family Q8IYI6
Lysosomal-associated transmembrane protein 4B (LAPTM4B) LAPTM4/LAPTM5 transporter family Q86VI4
Exocyst complex component 1 (EXOC1) SEC3 family Q9NV70
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 (SMARCE1) . Q969G3
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
C-Jun-amino-terminal kinase-interacting protein 4 (SPAG9) JIP scaffold family O60271
Golgin subfamily A member 1 (GOLGA1) . Q92805

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
12 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
13 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
14 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
15 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
16 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
17 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
18 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578