Details of the Target

General Information of Target

Target ID LDTP13532
Target Name Malignant T-cell-amplified sequence 1 (MCTS1)
Gene Name MCTS1
Gene ID 28985
Synonyms
MCT1; Malignant T-cell-amplified sequence 1; MCT-1; Multiple copies T-cell malignancies
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLEEDMEVAIKMVVVGNGAVGKSSMIQRYCKGIFTKDYKKTIGVDFLERQIQVNDEDVRL
MLWDTAGQEEFDAITKAYYRGAQACVLVFSTTDRESFEAVSSWREKVVAEVGDIPTVLVQ
NKIDLLDDSCIKNEEAEALAKRLKLRFYRTSVKEDLNVNEVFKYLAEKYLQKLKQQIAED
PELTHSSSNKIGVFNTSGGSHSGQNSGTLNGGDVINLRPNKQRTKKNRNPFSSCSIP
Target Bioclass
Other
Family
MCTS1 family
Subcellular location
Cytoplasm
Function
Anti-oncogene that plays a role in cell cycle regulation; decreases cell doubling time and anchorage-dependent growth; shortens the duration of G1 transit time and G1/S transition. When constitutively expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Involved in translation initiation; promotes recruitment of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role as translation enhancer; recruits the density-regulated protein/DENR and binds to the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile; up-regulates protein levels of BCL2L2, TFDP1, MRE11, CCND1 and E2F1, while mRNA levels remains constant. Hyperactivates DNA damage signaling pathway; increased gamma-irradiation-induced phosphorylation of histone H2AX, and induces damage foci formation. Increases the overall number of chromosomal abnormalities such as larger chromosomes formation and multiple chromosomal fusions when overexpressed in gamma-irradiated cells. May play a role in promoting lymphoid tumor development: lymphoid cell lines overexpressing MCTS1 exhibit increased growth rates and display increased protection against apoptosis. May contribute to the pathogenesis and progression of breast cancer via promotion of angiogenesis through the decline of inhibitory THBS1/thrombospondin-1, and inhibition of apoptosis. Involved in the process of proteasome degradation to down-regulate Tumor suppressor p53/TP53 in breast cancer cell; Positively regulates phosphorylation of MAPK1 and MAPK3. Involved in translation initiation; promotes aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits.
Uniprot ID
Q9ULC4
Ensemble ID
ENST00000371315.3
HGNC ID
HGNC:23357

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HUH28 SNV: p.H86Y DBIA    Probe Info 
NCIH1155 SNV: p.E7K DBIA    Probe Info 
RL952 SNV: p.I111V DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 34 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y124(20.00); Y88(20.00); Y169(6.82)  LDD0260  [1]
STPyne
 Probe Info  		K23(10.00); K51(5.28)  LDD0277  [2]
AZ-9
 Probe Info  		E75(1.58)  LDD2208  [3]
ONAyne
 Probe Info  		N.A.  LDD0273  [2]
Probe 1
 Probe Info  		Y79(14.15)  LDD3495  [4]
DBIA
 Probe Info  		C114(1.23)  LDD3310  [5]
BTD
 Probe Info  		C14(1.43); C144(1.02)  LDD1700  [6]
Jackson_14
 Probe Info  		2.56  LDD0123  [7]
AHL-Pu-1
 Probe Info  		C144(7.94)  LDD0168  [8]
HHS-465
 Probe Info  		Y169(10.00)  LDD2237  [9]
5E-2FA
 Probe Info  		H58(0.00); H176(0.00); H94(0.00)  LDD2235  [10]
ATP probe
 Probe Info  		K23(0.00); K4(0.00); K8(0.00); K99(0.00)  LDD0199  [11]
m-APA
 Probe Info  		H58(0.00); H94(0.00); H176(0.00)  LDD2231  [10]
4-Iodoacetamidophenylacetylene
 Probe Info  		C55(0.00); C14(0.00); C113(0.00); C144(0.00)  LDD0038  [12]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [13]
Lodoacetamide azide
 Probe Info  		C55(0.00); C14(0.00); C113(0.00); C144(0.00)  LDD0037  [12]
JW-RF-010
 Probe Info  		C14(0.00); C113(0.00)  LDD0026  [14]
TFBX
 Probe Info  		N.A.  LDD0027  [14]
WYneN
 Probe Info  		N.A.  LDD0021  [15]
WYneO
 Probe Info  		N.A.  LDD0022  [15]
Compound 10
 Probe Info  		N.A.  LDD2216  [16]
Compound 11
 Probe Info  		N.A.  LDD2213  [16]
ENE
 Probe Info  		N.A.  LDD0006  [15]
IPM
 Probe Info  		N.A.  LDD0005  [15]
PF-06672131
 Probe Info  		N.A.  LDD0152  [17]
VSF
 Probe Info  		N.A.  LDD0007  [15]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [18]
1c-yne
 Probe Info  		N.A.  LDD0228  [19]
1d-yne
 Probe Info  		N.A.  LDD0357  [19]
Acrolein
 Probe Info  		C113(0.00); C14(0.00); K8(0.00); C144(0.00)  LDD0217  [20]
Methacrolein
 Probe Info  		N.A.  LDD0218  [20]
W1
 Probe Info  		C113(0.00); C14(0.00); C144(0.00)  LDD0236  [21]
AOyne
 Probe Info  		15.00  LDD0443  [22]
NAIA_5
 Probe Info  		C55(0.00); C14(0.00); C113(0.00); C144(0.00)  LDD2223  [23]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe14
 Probe Info  		11.79  LDD0477  [24]
FFF probe3
 Probe Info  		20.00  LDD0464  [24]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C14(0.73)  LDD2095  [6]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C144(1.11); C113(0.94)  LDD2117  [6]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C14(1.29)  LDD2152  [6]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C144(0.47)  LDD2132  [6]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C144(0.74)  LDD2131  [6]
 LDCM0025  4SU-RNA HEK-293T C144(7.94)  LDD0168  [8]
 LDCM0026  4SU-RNA+native RNA HEK-293T C144(5.79); C14(2.12)  LDD0169  [8]
 LDCM0214  AC1 HEK-293T C144(1.02); C14(0.92); C113(0.92); C55(1.19)  LDD1507  [25]
 LDCM0215  AC10 HEK-293T C144(0.98); C14(0.99); C113(0.94)  LDD1508  [25]
 LDCM0226  AC11 HEK-293T C144(0.94); C14(0.94); C113(0.92)  LDD1509  [25]
 LDCM0237  AC12 HEK-293T C144(0.95); C14(0.90); C113(0.83)  LDD1510  [25]
 LDCM0259  AC14 HEK-293T C14(0.93); C113(0.98)  LDD1512  [25]
 LDCM0270  AC15 HEK-293T C14(0.92); C113(0.84)  LDD1513  [25]
 LDCM0276  AC17 HEK-293T C144(0.96); C14(0.90); C113(0.92); C55(0.97)  LDD1515  [25]
 LDCM0277  AC18 HEK-293T C144(0.97); C14(0.98); C113(1.02)  LDD1516  [25]
 LDCM0278  AC19 HEK-293T C144(0.79); C14(0.78); C113(0.81)  LDD1517  [25]
 LDCM0279  AC2 HEK-293T C144(1.11); C14(1.08); C113(0.94)  LDD1518  [25]
 LDCM0280  AC20 HEK-293T C144(0.98); C14(0.94); C113(0.89)  LDD1519  [25]
 LDCM0281  AC21 HEK-293T C144(1.05); C14(0.94); C113(0.94)  LDD1520  [25]
 LDCM0282  AC22 HEK-293T C14(0.93); C113(1.03)  LDD1521  [25]
 LDCM0283  AC23 HEK-293T C14(1.02); C113(0.85)  LDD1522  [25]
 LDCM0284  AC24 HEK-293T C144(0.91); C14(1.08); C113(0.98)  LDD1523  [25]
 LDCM0285  AC25 HEK-293T C144(1.01); C14(0.91); C113(0.97); C55(0.82)  LDD1524  [25]
 LDCM0286  AC26 HEK-293T C144(1.05); C14(0.95); C113(0.92)  LDD1525  [25]
 LDCM0287  AC27 HEK-293T C144(0.91); C14(0.95); C113(0.95)  LDD1526  [25]
 LDCM0288  AC28 HEK-293T C144(0.96); C14(0.93); C113(0.96)  LDD1527  [25]
 LDCM0289  AC29 HEK-293T C144(1.09); C14(0.94); C113(1.06)  LDD1528  [25]
 LDCM0290  AC3 HEK-293T C144(0.97); C14(0.91); C113(0.95)  LDD1529  [25]
 LDCM0291  AC30 HEK-293T C14(0.95); C113(1.03)  LDD1530  [25]
 LDCM0292  AC31 HEK-293T C14(1.00); C113(0.88)  LDD1531  [25]
 LDCM0293  AC32 HEK-293T C144(0.90); C14(1.09); C113(0.98)  LDD1532  [25]
 LDCM0294  AC33 HEK-293T C144(0.93); C14(0.91); C113(0.90); C55(0.93)  LDD1533  [25]
 LDCM0295  AC34 HEK-293T C144(1.02); C14(0.99); C113(0.94)  LDD1534  [25]
 LDCM0296  AC35 HEK-293T C144(0.97); C14(0.86); C113(0.89)  LDD1535  [25]
 LDCM0297  AC36 HEK-293T C144(0.94); C14(0.85); C113(0.85)  LDD1536  [25]
 LDCM0298  AC37 HEK-293T C144(0.93); C14(0.98); C113(1.01)  LDD1537  [25]
 LDCM0299  AC38 HEK-293T C14(0.87); C113(1.11)  LDD1538  [25]
 LDCM0300  AC39 HEK-293T C14(0.84); C113(0.90)  LDD1539  [25]
 LDCM0301  AC4 HEK-293T C144(1.04); C14(0.90); C113(0.90)  LDD1540  [25]
 LDCM0302  AC40 HEK-293T C144(0.89); C14(1.19); C113(1.03)  LDD1541  [25]
 LDCM0303  AC41 HEK-293T C144(0.92); C14(0.92); C113(0.91); C55(1.08)  LDD1542  [25]
 LDCM0304  AC42 HEK-293T C144(0.95); C14(0.97); C113(0.94)  LDD1543  [25]
 LDCM0305  AC43 HEK-293T C144(0.94); C14(0.86); C113(0.95)  LDD1544  [25]
 LDCM0306  AC44 HEK-293T C144(0.95); C14(0.95); C113(0.92)  LDD1545  [25]
 LDCM0307  AC45 HEK-293T C144(0.99); C14(0.89); C113(0.98)  LDD1546  [25]
 LDCM0308  AC46 HEK-293T C14(0.87); C113(1.06)  LDD1547  [25]
 LDCM0309  AC47 HEK-293T C14(0.85); C113(0.87)  LDD1548  [25]
 LDCM0310  AC48 HEK-293T C144(0.91); C14(1.21); C113(0.98)  LDD1549  [25]
 LDCM0311  AC49 HEK-293T C144(0.92); C14(0.93); C113(0.81); C55(0.83)  LDD1550  [25]
 LDCM0312  AC5 HEK-293T C144(1.22); C14(0.98); C113(1.04)  LDD1551  [25]
 LDCM0313  AC50 HEK-293T C144(1.02); C14(1.02); C113(1.01)  LDD1552  [25]
 LDCM0314  AC51 HEK-293T C144(1.01); C14(0.92); C113(1.00)  LDD1553  [25]
 LDCM0315  AC52 HEK-293T C144(0.96); C14(0.92); C113(0.84)  LDD1554  [25]
 LDCM0316  AC53 HEK-293T C144(1.03); C14(0.94); C113(0.95)  LDD1555  [25]
 LDCM0317  AC54 HEK-293T C14(0.86); C113(1.10)  LDD1556  [25]
 LDCM0318  AC55 HEK-293T C14(0.88); C113(0.81)  LDD1557  [25]
 LDCM0319  AC56 HEK-293T C144(0.86); C14(1.14); C113(0.96)  LDD1558  [25]
 LDCM0320  AC57 HEK-293T C144(0.96); C14(0.94); C113(0.86); C55(1.23)  LDD1559  [25]
 LDCM0321  AC58 HEK-293T C144(1.04); C14(1.03); C113(0.95)  LDD1560  [25]
 LDCM0322  AC59 HEK-293T C144(0.96); C14(0.92); C113(0.96)  LDD1561  [25]
 LDCM0323  AC6 HEK-293T C14(0.89); C113(1.11)  LDD1562  [25]
 LDCM0324  AC60 HEK-293T C144(0.98); C14(0.91); C113(0.82)  LDD1563  [25]
 LDCM0325  AC61 HEK-293T C144(1.01); C14(0.91); C113(1.01)  LDD1564  [25]
 LDCM0326  AC62 HEK-293T C14(0.92); C113(1.07)  LDD1565  [25]
 LDCM0327  AC63 HEK-293T C14(0.86); C113(0.88)  LDD1566  [25]
 LDCM0328  AC64 HEK-293T C144(1.02); C14(1.10); C113(0.99)  LDD1567  [25]
 LDCM0334  AC7 HEK-293T C14(0.99); C113(0.88)  LDD1568  [25]
 LDCM0345  AC8 HEK-293T C144(0.96); C14(1.21); C113(0.99)  LDD1569  [25]
 LDCM0520  AKOS000195272 MDA-MB-231 C14(1.08)  LDD2113  [6]
 LDCM0248  AKOS034007472 HEK-293T C144(1.04); C14(0.99); C113(0.95)  LDD1511  [25]
 LDCM0356  AKOS034007680 HEK-293T C144(0.97); C14(0.93); C113(0.88); C55(1.00)  LDD1570  [25]
 LDCM0275  AKOS034007705 HEK-293T C144(0.92); C14(1.07); C113(0.99)  LDD1514  [25]
 LDCM0498  BS-3668 MDA-MB-231 C144(0.78); C113(0.87)  LDD2091  [6]
 LDCM0108  Chloroacetamide HeLa C113(0.00); C14(0.00)  LDD0222  [20]
 LDCM0632  CL-Sc Hep-G2 C113(3.07); C14(1.10); C14(0.98)  LDD2227  [23]
 LDCM0367  CL1 HEK-293T C144(1.14); C14(0.90); C113(1.07)  LDD1571  [25]
 LDCM0368  CL10 HEK-293T C14(0.75); C113(1.01)  LDD1572  [25]
 LDCM0369  CL100 HEK-293T C144(0.99); C14(0.91); C113(0.93)  LDD1573  [25]
 LDCM0370  CL101 HEK-293T C144(1.01); C14(0.95); C113(0.98)  LDD1574  [25]
 LDCM0371  CL102 HEK-293T C144(1.01); C14(0.85); C113(0.92)  LDD1575  [25]
 LDCM0372  CL103 HEK-293T C144(0.99); C14(0.95); C113(0.95)  LDD1576  [25]
 LDCM0373  CL104 HEK-293T C144(1.04); C14(0.90); C113(0.92)  LDD1577  [25]
 LDCM0374  CL105 HEK-293T C144(1.05); C14(0.95); C113(0.85)  LDD1578  [25]
 LDCM0375  CL106 HEK-293T C144(1.06); C14(0.85); C113(0.93)  LDD1579  [25]
 LDCM0376  CL107 HEK-293T C144(0.97); C14(1.01); C113(0.99)  LDD1580  [25]
 LDCM0377  CL108 HEK-293T C144(1.01); C14(0.92); C113(0.91)  LDD1581  [25]
 LDCM0378  CL109 HEK-293T C144(1.03); C14(0.92); C113(0.99)  LDD1582  [25]
 LDCM0379  CL11 HEK-293T C14(0.93); C113(1.00)  LDD1583  [25]
 LDCM0380  CL110 HEK-293T C144(1.01); C14(0.81); C113(0.90)  LDD1584  [25]
 LDCM0381  CL111 HEK-293T C144(0.91); C14(0.99); C113(0.93)  LDD1585  [25]
 LDCM0382  CL112 HEK-293T C144(1.01); C14(0.84); C113(0.90)  LDD1586  [25]
 LDCM0383  CL113 HEK-293T C144(0.99); C14(0.97); C113(1.00)  LDD1587  [25]
 LDCM0384  CL114 HEK-293T C144(1.05); C14(0.76); C113(0.90)  LDD1588  [25]
 LDCM0385  CL115 HEK-293T C144(0.95); C14(0.94); C113(0.96)  LDD1589  [25]
 LDCM0386  CL116 HEK-293T C144(0.95); C14(0.82); C113(0.95)  LDD1590  [25]
 LDCM0387  CL117 HEK-293T C144(1.00); C14(0.92); C113(0.93)  LDD1591  [25]
 LDCM0388  CL118 HEK-293T C144(1.00); C14(0.83); C113(0.89)  LDD1592  [25]
 LDCM0389  CL119 HEK-293T C144(0.98); C14(0.96); C113(1.03)  LDD1593  [25]
 LDCM0390  CL12 HEK-293T C144(0.82); C14(1.07); C113(0.91)  LDD1594  [25]
 LDCM0391  CL120 HEK-293T C144(0.96); C14(0.84); C113(0.88)  LDD1595  [25]
 LDCM0392  CL121 HEK-293T C144(1.04); C14(0.95); C113(0.91)  LDD1596  [25]
 LDCM0393  CL122 HEK-293T C144(1.03); C14(0.89); C113(0.92)  LDD1597  [25]
 LDCM0394  CL123 HEK-293T C144(0.89); C14(0.91); C113(0.98)  LDD1598  [25]
 LDCM0395  CL124 HEK-293T C144(0.97); C14(0.85); C113(0.86)  LDD1599  [25]
 LDCM0396  CL125 HEK-293T C144(1.15); C14(0.94); C113(1.00)  LDD1600  [25]
 LDCM0397  CL126 HEK-293T C144(0.96); C14(0.84); C113(0.93)  LDD1601  [25]
 LDCM0398  CL127 HEK-293T C144(0.97); C14(0.98); C113(0.93)  LDD1602  [25]
 LDCM0399  CL128 HEK-293T C144(0.99); C14(0.86); C113(0.96)  LDD1603  [25]
 LDCM0400  CL13 HEK-293T C144(1.13); C14(0.92); C113(0.98)  LDD1604  [25]
 LDCM0401  CL14 HEK-293T C144(1.05); C14(0.97); C113(0.98)  LDD1605  [25]
 LDCM0402  CL15 HEK-293T C144(0.89); C14(0.94); C113(0.94)  LDD1606  [25]
 LDCM0403  CL16 HEK-293T C144(1.04); C14(1.02); C113(0.95)  LDD1607  [25]
 LDCM0404  CL17 HEK-293T C144(0.93); C14(0.82); C113(0.93); C55(0.86)  LDD1608  [25]
 LDCM0405  CL18 HEK-293T C144(0.95); C14(1.06); C113(0.97)  LDD1609  [25]
 LDCM0406  CL19 HEK-293T C144(1.00); C14(0.94); C113(0.94)  LDD1610  [25]
 LDCM0407  CL2 HEK-293T C144(1.15); C14(1.01); C113(0.99)  LDD1611  [25]
 LDCM0408  CL20 HEK-293T C144(0.91); C14(0.91); C113(0.84)  LDD1612  [25]
 LDCM0409  CL21 HEK-293T C144(0.87); C14(0.89); C113(0.91)  LDD1613  [25]
 LDCM0410  CL22 HEK-293T C14(0.99); C113(1.10)  LDD1614  [25]
 LDCM0411  CL23 HEK-293T C14(1.02); C113(1.00)  LDD1615  [25]
 LDCM0412  CL24 HEK-293T C144(0.78); C14(1.16); C113(1.05)  LDD1616  [25]
 LDCM0413  CL25 HEK-293T C144(1.06); C14(0.90); C113(1.05)  LDD1617  [25]
 LDCM0414  CL26 HEK-293T C144(1.06); C14(0.93); C113(0.99)  LDD1618  [25]
 LDCM0415  CL27 HEK-293T C144(0.97); C14(0.99); C113(0.96)  LDD1619  [25]
 LDCM0416  CL28 HEK-293T C144(1.00); C14(0.97); C113(0.88)  LDD1620  [25]
 LDCM0417  CL29 HEK-293T C144(1.03); C14(0.96); C113(0.92); C55(1.00)  LDD1621  [25]
 LDCM0418  CL3 HEK-293T C144(1.00); C14(1.04); C113(0.95)  LDD1622  [25]
 LDCM0419  CL30 HEK-293T C144(1.00); C14(1.07); C113(1.00)  LDD1623  [25]
 LDCM0420  CL31 HEK-293T C144(0.91); C14(0.92); C113(0.90)  LDD1624  [25]
 LDCM0421  CL32 HEK-293T C144(0.92); C14(0.97); C113(0.87)  LDD1625  [25]
 LDCM0422  CL33 HEK-293T C144(1.00); C14(0.82); C113(1.02)  LDD1626  [25]
 LDCM0423  CL34 HEK-293T C14(0.95); C113(1.03)  LDD1627  [25]
 LDCM0424  CL35 HEK-293T C14(0.96); C113(0.85)  LDD1628  [25]
 LDCM0425  CL36 HEK-293T C144(0.78); C14(1.08); C113(0.95)  LDD1629  [25]
 LDCM0426  CL37 HEK-293T C144(1.11); C14(0.98); C113(1.02)  LDD1630  [25]
 LDCM0428  CL39 HEK-293T C144(1.03); C14(0.96); C113(1.03)  LDD1632  [25]
 LDCM0429  CL4 HEK-293T C144(1.02); C14(0.94); C113(0.91)  LDD1633  [25]
 LDCM0430  CL40 HEK-293T C144(1.04); C14(0.94); C113(0.93)  LDD1634  [25]
 LDCM0431  CL41 HEK-293T C144(1.02); C14(0.90); C113(0.92); C55(0.85)  LDD1635  [25]
 LDCM0432  CL42 HEK-293T C144(1.07); C14(1.01); C113(1.00)  LDD1636  [25]
 LDCM0433  CL43 HEK-293T C144(1.01); C14(1.02); C113(0.96)  LDD1637  [25]
 LDCM0434  CL44 HEK-293T C144(0.93); C14(0.97); C113(0.92)  LDD1638  [25]
 LDCM0435  CL45 HEK-293T C144(1.02); C14(0.91); C113(1.06)  LDD1639  [25]
 LDCM0436  CL46 HEK-293T C14(0.96); C113(1.07)  LDD1640  [25]
 LDCM0437  CL47 HEK-293T C14(1.01); C113(0.85)  LDD1641  [25]
 LDCM0438  CL48 HEK-293T C144(0.86); C14(1.08); C113(0.98)  LDD1642  [25]
 LDCM0439  CL49 HEK-293T C144(1.16); C14(0.96); C113(1.05)  LDD1643  [25]
 LDCM0440  CL5 HEK-293T C144(0.95); C14(1.03); C113(0.96); C55(1.20)  LDD1644  [25]
 LDCM0441  CL50 HEK-293T C144(1.04); C14(0.87); C113(0.98)  LDD1645  [25]
 LDCM0443  CL52 HEK-293T C144(0.94); C14(0.87); C113(0.90)  LDD1646  [25]
 LDCM0444  CL53 HEK-293T C144(0.89); C14(0.82); C113(0.89); C55(0.87)  LDD1647  [25]
 LDCM0445  CL54 HEK-293T C144(0.98); C14(0.87); C113(0.91)  LDD1648  [25]
 LDCM0446  CL55 HEK-293T C144(0.96); C14(0.87); C113(0.94)  LDD1649  [25]
 LDCM0447  CL56 HEK-293T C144(0.93); C14(0.87); C113(0.83)  LDD1650  [25]
 LDCM0448  CL57 HEK-293T C144(0.91); C14(0.77); C113(1.06)  LDD1651  [25]
 LDCM0449  CL58 HEK-293T C14(0.84); C113(1.03)  LDD1652  [25]
 LDCM0450  CL59 HEK-293T C14(0.91); C113(0.86)  LDD1653  [25]
 LDCM0451  CL6 HEK-293T C144(0.96); C14(0.97); C113(1.01)  LDD1654  [25]
 LDCM0452  CL60 HEK-293T C144(0.82); C14(1.17); C113(1.01)  LDD1655  [25]
 LDCM0453  CL61 HEK-293T C144(1.18); C14(0.99); C113(1.12)  LDD1656  [25]
 LDCM0454  CL62 HEK-293T C144(1.10); C14(0.91); C113(0.99)  LDD1657  [25]
 LDCM0455  CL63 HEK-293T C144(0.94); C14(1.01); C113(0.96)  LDD1658  [25]
 LDCM0456  CL64 HEK-293T C144(0.95); C14(0.85); C113(0.95)  LDD1659  [25]
 LDCM0457  CL65 HEK-293T C144(0.99); C14(0.93); C113(0.87); C55(0.98)  LDD1660  [25]
 LDCM0458  CL66 HEK-293T C144(0.98); C14(1.02); C113(0.98)  LDD1661  [25]
 LDCM0459  CL67 HEK-293T C144(0.94); C14(0.90); C113(0.88)  LDD1662  [25]
 LDCM0460  CL68 HEK-293T C144(0.93); C14(0.91); C113(0.89)  LDD1663  [25]
 LDCM0461  CL69 HEK-293T C144(0.85); C14(0.91); C113(1.04)  LDD1664  [25]
 LDCM0462  CL7 HEK-293T C144(1.05); C14(0.94); C113(1.04)  LDD1665  [25]
 LDCM0463  CL70 HEK-293T C14(0.96); C113(1.05)  LDD1666  [25]
 LDCM0464  CL71 HEK-293T C14(0.94); C113(0.83)  LDD1667  [25]
 LDCM0465  CL72 HEK-293T C144(0.82); C14(1.19); C113(1.00)  LDD1668  [25]
 LDCM0466  CL73 HEK-293T C144(1.10); C14(0.94); C113(1.08)  LDD1669  [25]
 LDCM0467  CL74 HEK-293T C144(1.04); C14(0.92); C113(0.99)  LDD1670  [25]
 LDCM0469  CL76 HEK-293T C144(0.99); C14(0.93); C113(0.90)  LDD1672  [25]
 LDCM0470  CL77 HEK-293T C144(0.92); C14(0.85); C113(0.94); C55(1.31)  LDD1673  [25]
 LDCM0471  CL78 HEK-293T C144(0.97); C14(1.04); C113(1.02)  LDD1674  [25]
 LDCM0472  CL79 HEK-293T C144(1.02); C14(0.98); C113(0.97)  LDD1675  [25]
 LDCM0473  CL8 HEK-293T C144(0.91); C14(0.65); C113(0.79)  LDD1676  [25]
 LDCM0474  CL80 HEK-293T C144(0.96); C14(0.93); C113(0.94)  LDD1677  [25]
 LDCM0475  CL81 HEK-293T C144(0.88); C14(0.98); C113(0.96)  LDD1678  [25]
 LDCM0476  CL82 HEK-293T C14(0.92); C113(1.04)  LDD1679  [25]
 LDCM0477  CL83 HEK-293T C14(0.90); C113(0.79)  LDD1680  [25]
 LDCM0478  CL84 HEK-293T C144(0.91); C14(1.08); C113(0.95)  LDD1681  [25]
 LDCM0479  CL85 HEK-293T C144(1.31); C14(1.02); C113(1.08)  LDD1682  [25]
 LDCM0480  CL86 HEK-293T C144(1.25); C14(0.88); C113(0.97)  LDD1683  [25]
 LDCM0481  CL87 HEK-293T C144(0.99); C14(0.97); C113(0.94)  LDD1684  [25]
 LDCM0482  CL88 HEK-293T C144(1.01); C14(0.92); C113(0.93)  LDD1685  [25]
 LDCM0483  CL89 HEK-293T C144(0.98); C14(0.97); C113(0.93); C55(1.28)  LDD1686  [25]
 LDCM0484  CL9 HEK-293T C144(0.84); C14(0.93); C113(1.09)  LDD1687  [25]
 LDCM0485  CL90 HEK-293T C144(0.95); C14(0.79); C113(0.90)  LDD1688  [25]
 LDCM0486  CL91 HEK-293T C144(1.08); C14(1.00); C113(0.97)  LDD1689  [25]
 LDCM0487  CL92 HEK-293T C144(0.95); C14(0.87); C113(0.84)  LDD1690  [25]
 LDCM0488  CL93 HEK-293T C144(1.18); C14(0.86); C113(0.99)  LDD1691  [25]
 LDCM0489  CL94 HEK-293T C14(0.86); C113(1.08)  LDD1692  [25]
 LDCM0490  CL95 HEK-293T C14(0.76); C113(0.83)  LDD1693  [25]
 LDCM0491  CL96 HEK-293T C144(1.26); C14(1.10); C113(0.99)  LDD1694  [25]
 LDCM0492  CL97 HEK-293T C144(1.04); C14(0.89); C113(0.95)  LDD1695  [25]
 LDCM0493  CL98 HEK-293T C144(1.00); C14(0.88); C113(0.89)  LDD1696  [25]
 LDCM0494  CL99 HEK-293T C144(1.03); C14(1.04); C113(0.99)  LDD1697  [25]
 LDCM0191  Compound 21 HEK-293T 10.10  LDD0508  [24]
 LDCM0192  Compound 35 HEK-293T 6.35  LDD0509  [24]
 LDCM0193  Compound 36 HEK-293T 8.20  LDD0511  [24]
 LDCM0634  CY-0357 Hep-G2 C14(1.09); C14(0.65)  LDD2228  [23]
 LDCM0495  E2913 HEK-293T C144(1.06); C14(0.96); C113(0.97)  LDD1698  [25]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C113(2.06); C14(1.32)  LDD1702  [6]
 LDCM0625  F8 Ramos C14(2.24); C113(0.71)  LDD2187  [26]
 LDCM0572  Fragment10 Ramos C14(0.82); C113(0.57)  LDD2189  [26]
 LDCM0573  Fragment11 Ramos C14(0.02); C113(0.25)  LDD2190  [26]
 LDCM0574  Fragment12 Ramos C14(0.78); C113(0.59)  LDD2191  [26]
 LDCM0575  Fragment13 Ramos C14(0.85); C113(1.29)  LDD2192  [26]
 LDCM0576  Fragment14 Ramos C14(0.89); C113(0.73)  LDD2193  [26]
 LDCM0579  Fragment20 Ramos C14(0.68); C113(0.55)  LDD2194  [26]
 LDCM0580  Fragment21 Ramos C14(0.86); C113(0.95)  LDD2195  [26]
 LDCM0582  Fragment23 Ramos C14(0.87); C113(1.06)  LDD2196  [26]
 LDCM0578  Fragment27 Ramos C14(0.87); C113(1.01)  LDD2197  [26]
 LDCM0586  Fragment28 Ramos C14(0.81); C113(1.22)  LDD2198  [26]
 LDCM0588  Fragment30 Ramos C14(0.89); C113(1.18)  LDD2199  [26]
 LDCM0589  Fragment31 Ramos C14(0.83); C113(1.58)  LDD2200  [26]
 LDCM0590  Fragment32 Ramos C14(0.68); C113(0.51)  LDD2201  [26]
 LDCM0468  Fragment33 HEK-293T C144(1.00); C14(0.99); C113(0.97)  LDD1671  [25]
 LDCM0596  Fragment38 Ramos C14(0.75); C113(0.85)  LDD2203  [26]
 LDCM0566  Fragment4 Ramos C14(0.82); C113(0.87)  LDD2184  [26]
 LDCM0427  Fragment51 HEK-293T C144(1.07); C14(0.94); C113(0.94)  LDD1631  [25]
 LDCM0610  Fragment52 Ramos C14(1.12); C113(1.14)  LDD2204  [26]
 LDCM0614  Fragment56 Ramos C14(0.93); C113(1.01)  LDD2205  [26]
 LDCM0569  Fragment7 Ramos C14(0.74); C113(0.46)  LDD2186  [26]
 LDCM0571  Fragment9 Ramos C14(0.60); C113(0.43)  LDD2188  [26]
 LDCM0107  IAA HeLa N.A.  LDD0221  [20]
 LDCM0022  KB02 HEK-293T C14(1.00); C113(0.99); C144(1.01)  LDD1492  [25]
 LDCM0023  KB03 HEK-293T C14(0.99); C113(1.10); C144(0.97)  LDD1497  [25]
 LDCM0024  KB05 COLO792 C114(1.23)  LDD3310  [5]
 LDCM0109  NEM HeLa N.A.  LDD0225  [20]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C14(0.20); C113(0.93)  LDD2089  [6]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C14(2.89)  LDD2090  [6]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C14(0.92)  LDD2093  [6]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C144(2.67)  LDD2094  [6]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C14(1.22)  LDD2097  [6]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C144(1.01)  LDD2098  [6]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C144(1.77); C113(0.94)  LDD2099  [6]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C14(1.31)  LDD2101  [6]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C113(0.70)  LDD2106  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C14(0.91); C144(1.04); C113(0.88)  LDD2107  [6]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C14(0.59); C144(0.70)  LDD2109  [6]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C14(1.01); C144(1.76)  LDD2111  [6]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C14(0.94)  LDD2115  [6]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C144(1.16)  LDD2119  [6]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C144(0.63)  LDD2120  [6]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C113(0.92)  LDD2123  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C14(0.93); C144(1.01)  LDD2125  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C14(0.94)  LDD2127  [6]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C113(0.83)  LDD2128  [6]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C14(0.76)  LDD2129  [6]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C14(0.78); C144(0.62)  LDD2133  [6]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C14(0.77)  LDD2134  [6]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C14(0.97); C144(0.65)  LDD2135  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C14(1.02); C144(1.17); C113(0.81)  LDD2136  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C144(0.98); C113(0.94)  LDD2137  [6]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C14(1.43); C144(1.02)  LDD1700  [6]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C14(1.02); C144(1.19)  LDD2140  [6]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C14(3.00)  LDD2143  [6]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C144(1.18)  LDD2144  [6]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C14(0.84); C144(0.80)  LDD2146  [6]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C14(0.85)  LDD2148  [6]
 LDCM0627  NUDT7-COV-1 HEK-293T C14(0.97)  LDD2206  [27]
 LDCM0628  OTUB2-COV-1 HEK-293T C14(0.68); C14(0.11)  LDD2207  [27]
 LDCM0131  RA190 MM1.R C14(1.30)  LDD0304  [28]
 LDCM0016  Ranjitkar_cp1 MDA-MB-231 2.56  LDD0123  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Density-regulated protein (DENR) DENR family O43583

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
8 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
9 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
10 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
11 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
12 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
13 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
14 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
15 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
16 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
17 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
18 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
19 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
20 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
21 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
22 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
23 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
24 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
25 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
26 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
27 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
28 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.