Details of the Target

General Information of Target

Target ID LDTP12578
Target Name Keratin, type II cuticular Hb4 (KRT84)
Gene Name KRT84
Gene ID 3890
Synonyms
KRTHB4; Keratin, type II cuticular Hb4; Keratin-84; K84; Type II hair keratin Hb4; Type-II keratin Kb24
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNREGAPGKSPEEMYIQQKVRVLLMLRKMGSNLTASEEEFLRTYAGVVNSQLSQLPPHSI
DQGAEDVVMAFSRSETEDRRQ
Target Bioclass
Other
Family
Intermediate filament family
Uniprot ID
Q9NSB2
Ensemble ID
ENST00000257951.3
HGNC ID
HGNC:6461

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
ONAyne
 Probe Info  		K438(10.00)  LDD0274  [1]
AZ-9
 Probe Info  		E473(0.78); D181(0.99); E187(0.98)  LDD2208  [2]
SAHA-CA-4PAP
 Probe Info  		N.A.  LDD0361  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [4]
HHS-465
 Probe Info  		K191(0.00); K182(0.00)  LDD2240  [5]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		3.80  LDD0136  [6]
STS-2
 Probe Info  		1.00  LDD0139  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0625  F8 Ramos C477(0.80)  LDD2187  [7]
 LDCM0573  Fragment11 Ramos C477(2.08)  LDD2190  [7]
 LDCM0574  Fragment12 Ramos C477(0.91)  LDD2191  [7]
 LDCM0575  Fragment13 Ramos C477(1.33)  LDD2192  [7]
 LDCM0576  Fragment14 Ramos C477(0.60)  LDD2193  [7]
 LDCM0580  Fragment21 Ramos C477(1.07)  LDD2195  [7]
 LDCM0582  Fragment23 Ramos C477(0.84)  LDD2196  [7]
 LDCM0578  Fragment27 Ramos C477(0.66)  LDD2197  [7]
 LDCM0586  Fragment28 Ramos C477(0.64)  LDD2198  [7]
 LDCM0588  Fragment30 Ramos C477(1.02)  LDD2199  [7]
 LDCM0589  Fragment31 Ramos C477(1.19)  LDD2200  [7]
 LDCM0590  Fragment32 Ramos C477(2.62)  LDD2201  [7]
 LDCM0468  Fragment33 Ramos C477(1.28)  LDD2202  [7]
 LDCM0596  Fragment38 Ramos C477(0.67)  LDD2203  [7]
 LDCM0566  Fragment4 Ramos C477(1.14)  LDD2184  [7]
 LDCM0610  Fragment52 Ramos C477(0.56)  LDD2204  [7]
 LDCM0614  Fragment56 Ramos C477(0.50)  LDD2205  [7]
 LDCM0569  Fragment7 Ramos C477(1.64)  LDD2186  [7]
 LDCM0022  KB02 Ramos C477(0.37)  LDD2182  [7]
 LDCM0023  KB03 Ramos C477(0.41)  LDD2183  [7]
 LDCM0024  KB05 Ramos C477(0.32)  LDD2185  [7]
 LDCM0096  SAHA K562 N.A.  LDD0361  [3]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
3 Streamlined Target Deconvolution Approach Utilizing a Single Photoreactive Chloroalkane Capture Tag. ACS Chem Biol. 2021 Feb 19;16(2):404-413. doi: 10.1021/acschembio.0c00987. Epub 2021 Feb 5.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
6 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
7 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578