Details of the Target

General Information of Target

Target ID LDTP09861
Target Name General transcription factor IIH subunit 4 (GTF2H4)
Gene Name GTF2H4
Gene ID 2968
Synonyms
General transcription factor IIH subunit 4; Basic transcription factor 2 52 kDa subunit; BTF2 p52; General transcription factor IIH polypeptide 4; TFIIH basal transcription factor complex p52 subunit
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLWKITDNVKYEEDCEDRHDGSSNGNPRVPHLSSAGQHLYSPAPPLSHTGVAEYQPPPYF
PPPYQQLAYSQSADPYSHLGEAYAAAINPLHQPAPTGSQQQAWPGRQSQEGAGLPSHHGR
PAGLLPHLSGLEAGAVSARRDAYRRSDLLLPHAHALDAAGLAENLGLHDMPHQMDEVQNV
DDQHLLLHDQTVIRKGPISMTKNPLNLPCQKELVGAVMNPTEVFCSVPGRLSLLSSTSKY
KVTVAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRSLREKLDKIGLNLPAGRRKAAHVT
LLTSLVEGEAVHLARDFAYVCEAEFPSKPVAEYLTRPHLGGRNEMAARKNMLLAAQQLCK
EFTELLSQDRTPHGTSRLAPVLETNIQNCLSHFSLITHGFGSQAICAAVSALQNYIKEAL
IVIDKSYMNPGDQSPADSNKTLEKMEKHRK
Target Bioclass
Other
Family
TFB2 family
Subcellular location
Nucleus
Function
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
Uniprot ID
Q92759
Ensemble ID
ENST00000259895.9
HGNC ID
HGNC:4658

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO792 SNV: p.S147F DBIA    Probe Info 
LNCaP clone FGC SNV: p.R274K DBIA    Probe Info 
MCAS SNV: p.R46T DBIA    Probe Info 
MOLT4 SNV: p.M57I IA-alkyne    Probe Info 
OVCAR8 SNV: p.L327F .
SKES1 SNV: p.H366Q DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
BTD
 Probe Info  		C16(0.68)  LDD2089  [2]
Curcusone 37
 Probe Info  		2.54  LDD0188  [3]
AHL-Pu-1
 Probe Info  		C16(2.13)  LDD0168  [4]
DBIA
 Probe Info  		C16(4.74)  LDD0209  [5]
Acrolein
 Probe Info  		C41(0.00); C16(0.00)  LDD0222  [6]
ATP probe
 Probe Info  		N.A.  LDD0199  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [8]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [8]
IPM
 Probe Info  		N.A.  LDD0147  [9]
TFBX
 Probe Info  		N.A.  LDD0148  [9]
AOyne
 Probe Info  		15.00  LDD0443  [10]
NAIA_5
 Probe Info  		C16(0.00); C41(0.00)  LDD2223  [11]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C160
 Probe Info  		7.21  LDD1840  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C16(0.97)  LDD2117  [2]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C16(1.18)  LDD2152  [2]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C16(0.52)  LDD2132  [2]
 LDCM0025  4SU-RNA HEK-293T C16(2.13)  LDD0168  [4]
 LDCM0026  4SU-RNA+native RNA HEK-293T C16(2.45)  LDD0169  [4]
 LDCM0214  AC1 HEK-293T C41(1.02)  LDD1507  [13]
 LDCM0215  AC10 HEK-293T C41(0.94)  LDD1508  [13]
 LDCM0226  AC11 HEK-293T C41(0.97)  LDD1509  [13]
 LDCM0237  AC12 HEK-293T C41(0.98)  LDD1510  [13]
 LDCM0259  AC14 HEK-293T C41(0.93)  LDD1512  [13]
 LDCM0270  AC15 HEK-293T C41(1.00)  LDD1513  [13]
 LDCM0276  AC17 HEK-293T C41(0.96)  LDD1515  [13]
 LDCM0277  AC18 HEK-293T C41(0.94)  LDD1516  [13]
 LDCM0278  AC19 HEK-293T C41(0.91)  LDD1517  [13]
 LDCM0279  AC2 HEK-293T C41(0.99)  LDD1518  [13]
 LDCM0280  AC20 HEK-293T C41(0.97)  LDD1519  [13]
 LDCM0281  AC21 HEK-293T C41(0.84)  LDD1520  [13]
 LDCM0282  AC22 HEK-293T C41(0.96)  LDD1521  [13]
 LDCM0283  AC23 HEK-293T C41(0.93)  LDD1522  [13]
 LDCM0284  AC24 HEK-293T C41(1.14)  LDD1523  [13]
 LDCM0285  AC25 HEK-293T C41(0.98)  LDD1524  [13]
 LDCM0286  AC26 HEK-293T C41(0.92)  LDD1525  [13]
 LDCM0287  AC27 HEK-293T C41(0.92)  LDD1526  [13]
 LDCM0288  AC28 HEK-293T C41(0.92)  LDD1527  [13]
 LDCM0289  AC29 HEK-293T C41(0.79)  LDD1528  [13]
 LDCM0290  AC3 HEK-293T C41(0.97)  LDD1529  [13]
 LDCM0291  AC30 HEK-293T C41(0.79)  LDD1530  [13]
 LDCM0292  AC31 HEK-293T C41(0.96)  LDD1531  [13]
 LDCM0293  AC32 HEK-293T C41(0.86)  LDD1532  [13]
 LDCM0294  AC33 HEK-293T C41(0.93)  LDD1533  [13]
 LDCM0295  AC34 HEK-293T C41(0.95)  LDD1534  [13]
 LDCM0296  AC35 HEK-293T C41(0.99)  LDD1535  [13]
 LDCM0297  AC36 HEK-293T C41(0.88)  LDD1536  [13]
 LDCM0298  AC37 HEK-293T C41(0.99)  LDD1537  [13]
 LDCM0299  AC38 HEK-293T C41(0.92)  LDD1538  [13]
 LDCM0300  AC39 HEK-293T C41(0.95)  LDD1539  [13]
 LDCM0301  AC4 HEK-293T C41(0.93)  LDD1540  [13]
 LDCM0302  AC40 HEK-293T C41(0.85)  LDD1541  [13]
 LDCM0303  AC41 HEK-293T C41(0.97)  LDD1542  [13]
 LDCM0304  AC42 HEK-293T C41(0.93)  LDD1543  [13]
 LDCM0305  AC43 HEK-293T C41(0.99)  LDD1544  [13]
 LDCM0306  AC44 HEK-293T C41(0.99)  LDD1545  [13]
 LDCM0307  AC45 HEK-293T C41(0.88)  LDD1546  [13]
 LDCM0308  AC46 HEK-293T C41(0.95)  LDD1547  [13]
 LDCM0309  AC47 HEK-293T C41(0.92)  LDD1548  [13]
 LDCM0310  AC48 HEK-293T C41(1.17)  LDD1549  [13]
 LDCM0311  AC49 HEK-293T C41(1.01)  LDD1550  [13]
 LDCM0312  AC5 HEK-293T C41(0.98)  LDD1551  [13]
 LDCM0313  AC50 HEK-293T C41(0.99)  LDD1552  [13]
 LDCM0314  AC51 HEK-293T C41(0.97)  LDD1553  [13]
 LDCM0315  AC52 HEK-293T C41(0.99)  LDD1554  [13]
 LDCM0316  AC53 HEK-293T C41(0.93)  LDD1555  [13]
 LDCM0317  AC54 HEK-293T C41(0.94)  LDD1556  [13]
 LDCM0318  AC55 HEK-293T C41(0.95)  LDD1557  [13]
 LDCM0319  AC56 HEK-293T C41(1.12)  LDD1558  [13]
 LDCM0320  AC57 HEK-293T C41(1.03)  LDD1559  [13]
 LDCM0321  AC58 HEK-293T C41(1.02)  LDD1560  [13]
 LDCM0322  AC59 HEK-293T C41(0.96)  LDD1561  [13]
 LDCM0323  AC6 HEK-293T C41(0.98)  LDD1562  [13]
 LDCM0324  AC60 HEK-293T C41(0.86)  LDD1563  [13]
 LDCM0325  AC61 HEK-293T C41(0.94)  LDD1564  [13]
 LDCM0326  AC62 HEK-293T C41(0.90)  LDD1565  [13]
 LDCM0327  AC63 HEK-293T C41(1.05)  LDD1566  [13]
 LDCM0328  AC64 HEK-293T C41(1.07)  LDD1567  [13]
 LDCM0334  AC7 HEK-293T C41(1.10)  LDD1568  [13]
 LDCM0345  AC8 HEK-293T C41(0.74)  LDD1569  [13]
 LDCM0248  AKOS034007472 HEK-293T C41(0.96)  LDD1511  [13]
 LDCM0356  AKOS034007680 HEK-293T C41(0.98)  LDD1570  [13]
 LDCM0275  AKOS034007705 HEK-293T C41(0.87)  LDD1514  [13]
 LDCM0156  Aniline NCI-H1299 8.94  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa C41(0.00); C16(0.00)  LDD0222  [6]
 LDCM0367  CL1 HEK-293T C41(1.02)  LDD1571  [13]
 LDCM0368  CL10 HEK-293T C41(1.21)  LDD1572  [13]
 LDCM0369  CL100 HEK-293T C41(0.95)  LDD1573  [13]
 LDCM0370  CL101 HEK-293T C41(0.99)  LDD1574  [13]
 LDCM0371  CL102 HEK-293T C41(1.11)  LDD1575  [13]
 LDCM0372  CL103 HEK-293T C41(0.83)  LDD1576  [13]
 LDCM0373  CL104 HEK-293T C41(0.89)  LDD1577  [13]
 LDCM0374  CL105 HEK-293T C41(1.14)  LDD1578  [13]
 LDCM0375  CL106 HEK-293T C41(0.99)  LDD1579  [13]
 LDCM0376  CL107 HEK-293T C41(0.98)  LDD1580  [13]
 LDCM0377  CL108 HEK-293T C41(0.98)  LDD1581  [13]
 LDCM0378  CL109 HEK-293T C41(0.93)  LDD1582  [13]
 LDCM0379  CL11 HEK-293T C41(1.15)  LDD1583  [13]
 LDCM0380  CL110 HEK-293T C41(1.03)  LDD1584  [13]
 LDCM0381  CL111 HEK-293T C41(0.88)  LDD1585  [13]
 LDCM0382  CL112 HEK-293T C41(1.11)  LDD1586  [13]
 LDCM0383  CL113 HEK-293T C41(1.10)  LDD1587  [13]
 LDCM0384  CL114 HEK-293T C41(0.94)  LDD1588  [13]
 LDCM0385  CL115 HEK-293T C41(0.91)  LDD1589  [13]
 LDCM0386  CL116 HEK-293T C41(0.94)  LDD1590  [13]
 LDCM0387  CL117 HEK-293T C41(1.02)  LDD1591  [13]
 LDCM0388  CL118 HEK-293T C41(0.90)  LDD1592  [13]
 LDCM0389  CL119 HEK-293T C41(1.03)  LDD1593  [13]
 LDCM0390  CL12 HEK-293T C41(1.15)  LDD1594  [13]
 LDCM0391  CL120 HEK-293T C41(0.94)  LDD1595  [13]
 LDCM0392  CL121 HEK-293T C41(1.08)  LDD1596  [13]
 LDCM0393  CL122 HEK-293T C41(1.04)  LDD1597  [13]
 LDCM0394  CL123 HEK-293T C41(0.97)  LDD1598  [13]
 LDCM0395  CL124 HEK-293T C41(1.04)  LDD1599  [13]
 LDCM0396  CL125 HEK-293T C41(1.08)  LDD1600  [13]
 LDCM0397  CL126 HEK-293T C41(1.00)  LDD1601  [13]
 LDCM0398  CL127 HEK-293T C41(0.95)  LDD1602  [13]
 LDCM0399  CL128 HEK-293T C41(0.97)  LDD1603  [13]
 LDCM0400  CL13 HEK-293T C41(0.97)  LDD1604  [13]
 LDCM0401  CL14 HEK-293T C41(0.97)  LDD1605  [13]
 LDCM0402  CL15 HEK-293T C41(0.93)  LDD1606  [13]
 LDCM0403  CL16 HEK-293T C41(0.96)  LDD1607  [13]
 LDCM0404  CL17 HEK-293T C41(0.96)  LDD1608  [13]
 LDCM0405  CL18 HEK-293T C41(0.96)  LDD1609  [13]
 LDCM0406  CL19 HEK-293T C41(1.01)  LDD1610  [13]
 LDCM0407  CL2 HEK-293T C41(0.97)  LDD1611  [13]
 LDCM0408  CL20 HEK-293T C41(1.12)  LDD1612  [13]
 LDCM0409  CL21 HEK-293T C41(0.95)  LDD1613  [13]
 LDCM0410  CL22 HEK-293T C41(1.30)  LDD1614  [13]
 LDCM0411  CL23 HEK-293T C41(1.30)  LDD1615  [13]
 LDCM0412  CL24 HEK-293T C41(0.89)  LDD1616  [13]
 LDCM0413  CL25 HEK-293T C41(1.07)  LDD1617  [13]
 LDCM0414  CL26 HEK-293T C41(0.97)  LDD1618  [13]
 LDCM0415  CL27 HEK-293T C41(1.00)  LDD1619  [13]
 LDCM0416  CL28 HEK-293T C41(1.01)  LDD1620  [13]
 LDCM0417  CL29 HEK-293T C41(0.94)  LDD1621  [13]
 LDCM0418  CL3 HEK-293T C41(0.95)  LDD1622  [13]
 LDCM0419  CL30 HEK-293T C41(0.91)  LDD1623  [13]
 LDCM0420  CL31 HEK-293T C41(0.96)  LDD1624  [13]
 LDCM0421  CL32 HEK-293T C41(1.19)  LDD1625  [13]
 LDCM0422  CL33 HEK-293T C41(1.30)  LDD1626  [13]
 LDCM0423  CL34 HEK-293T C41(1.19)  LDD1627  [13]
 LDCM0424  CL35 HEK-293T C41(1.09)  LDD1628  [13]
 LDCM0425  CL36 HEK-293T C41(0.98)  LDD1629  [13]
 LDCM0426  CL37 HEK-293T C41(1.28)  LDD1630  [13]
 LDCM0428  CL39 HEK-293T C41(0.91)  LDD1632  [13]
 LDCM0429  CL4 HEK-293T C41(0.95)  LDD1633  [13]
 LDCM0430  CL40 HEK-293T C41(1.06)  LDD1634  [13]
 LDCM0431  CL41 HEK-293T C41(0.90)  LDD1635  [13]
 LDCM0432  CL42 HEK-293T C41(0.98)  LDD1636  [13]
 LDCM0433  CL43 HEK-293T C41(0.95)  LDD1637  [13]
 LDCM0434  CL44 HEK-293T C41(1.15)  LDD1638  [13]
 LDCM0435  CL45 HEK-293T C41(0.87)  LDD1639  [13]
 LDCM0436  CL46 HEK-293T C41(1.22)  LDD1640  [13]
 LDCM0437  CL47 HEK-293T C41(1.24)  LDD1641  [13]
 LDCM0438  CL48 HEK-293T C41(1.03)  LDD1642  [13]
 LDCM0439  CL49 HEK-293T C41(1.02)  LDD1643  [13]
 LDCM0440  CL5 HEK-293T C41(0.99)  LDD1644  [13]
 LDCM0441  CL50 HEK-293T C41(0.92)  LDD1645  [13]
 LDCM0443  CL52 HEK-293T C41(0.95)  LDD1646  [13]
 LDCM0444  CL53 HEK-293T C41(0.88)  LDD1647  [13]
 LDCM0445  CL54 HEK-293T C41(0.95)  LDD1648  [13]
 LDCM0446  CL55 HEK-293T C41(1.04)  LDD1649  [13]
 LDCM0447  CL56 HEK-293T C41(1.02)  LDD1650  [13]
 LDCM0448  CL57 HEK-293T C41(0.73)  LDD1651  [13]
 LDCM0449  CL58 HEK-293T C41(1.21)  LDD1652  [13]
 LDCM0450  CL59 HEK-293T C41(1.21)  LDD1653  [13]
 LDCM0451  CL6 HEK-293T C41(1.03)  LDD1654  [13]
 LDCM0452  CL60 HEK-293T C41(1.07)  LDD1655  [13]
 LDCM0453  CL61 HEK-293T C41(0.90)  LDD1656  [13]
 LDCM0454  CL62 HEK-293T C41(0.98)  LDD1657  [13]
 LDCM0455  CL63 HEK-293T C41(0.97)  LDD1658  [13]
 LDCM0456  CL64 HEK-293T C41(0.94)  LDD1659  [13]
 LDCM0457  CL65 HEK-293T C41(0.90)  LDD1660  [13]
 LDCM0458  CL66 HEK-293T C41(0.94)  LDD1661  [13]
 LDCM0459  CL67 HEK-293T C41(0.93)  LDD1662  [13]
 LDCM0460  CL68 HEK-293T C41(1.03)  LDD1663  [13]
 LDCM0461  CL69 HEK-293T C41(0.87)  LDD1664  [13]
 LDCM0462  CL7 HEK-293T C41(1.04)  LDD1665  [13]
 LDCM0463  CL70 HEK-293T C41(1.17)  LDD1666  [13]
 LDCM0464  CL71 HEK-293T C41(1.24)  LDD1667  [13]
 LDCM0465  CL72 HEK-293T C41(1.05)  LDD1668  [13]
 LDCM0466  CL73 HEK-293T C41(0.96)  LDD1669  [13]
 LDCM0467  CL74 HEK-293T C41(1.05)  LDD1670  [13]
 LDCM0469  CL76 HEK-293T C41(1.00)  LDD1672  [13]
 LDCM0470  CL77 HEK-293T C41(1.04)  LDD1673  [13]
 LDCM0471  CL78 HEK-293T C41(0.98)  LDD1674  [13]
 LDCM0472  CL79 HEK-293T C41(1.00)  LDD1675  [13]
 LDCM0473  CL8 HEK-293T C41(1.71)  LDD1676  [13]
 LDCM0474  CL80 HEK-293T C41(1.24)  LDD1677  [13]
 LDCM0475  CL81 HEK-293T C41(0.95)  LDD1678  [13]
 LDCM0476  CL82 HEK-293T C41(1.13)  LDD1679  [13]
 LDCM0477  CL83 HEK-293T C41(1.12)  LDD1680  [13]
 LDCM0478  CL84 HEK-293T C41(1.15)  LDD1681  [13]
 LDCM0479  CL85 HEK-293T C41(1.02)  LDD1682  [13]
 LDCM0480  CL86 HEK-293T C41(1.05)  LDD1683  [13]
 LDCM0481  CL87 HEK-293T C41(0.96)  LDD1684  [13]
 LDCM0482  CL88 HEK-293T C41(1.01)  LDD1685  [13]
 LDCM0483  CL89 HEK-293T C41(1.06)  LDD1686  [13]
 LDCM0484  CL9 HEK-293T C41(0.77)  LDD1687  [13]
 LDCM0485  CL90 HEK-293T C41(1.14)  LDD1688  [13]
 LDCM0486  CL91 HEK-293T C41(1.00)  LDD1689  [13]
 LDCM0487  CL92 HEK-293T C41(1.04)  LDD1690  [13]
 LDCM0488  CL93 HEK-293T C41(1.18)  LDD1691  [13]
 LDCM0489  CL94 HEK-293T C41(1.11)  LDD1692  [13]
 LDCM0490  CL95 HEK-293T C41(1.10)  LDD1693  [13]
 LDCM0491  CL96 HEK-293T C41(0.95)  LDD1694  [13]
 LDCM0492  CL97 HEK-293T C41(1.28)  LDD1695  [13]
 LDCM0493  CL98 HEK-293T C41(1.01)  LDD1696  [13]
 LDCM0494  CL99 HEK-293T C41(0.92)  LDD1697  [13]
 LDCM0033  Curcusone1d MCF-7 2.54  LDD0188  [3]
 LDCM0495  E2913 HEK-293T C41(0.91)  LDD1698  [13]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C41(14.08)  LDD1702  [2]
 LDCM0625  F8 Ramos C41(0.98)  LDD2187  [14]
 LDCM0573  Fragment11 Ramos C41(0.41)  LDD2190  [14]
 LDCM0574  Fragment12 Ramos C41(2.36)  LDD2191  [14]
 LDCM0575  Fragment13 Ramos C41(1.44)  LDD2192  [14]
 LDCM0576  Fragment14 Ramos C41(1.21)  LDD2193  [14]
 LDCM0579  Fragment20 Ramos C41(2.73)  LDD2194  [14]
 LDCM0580  Fragment21 Ramos C41(0.92)  LDD2195  [14]
 LDCM0578  Fragment27 Ramos C41(1.01)  LDD2197  [14]
 LDCM0586  Fragment28 Ramos C41(1.50)  LDD2198  [14]
 LDCM0588  Fragment30 Ramos C41(1.18)  LDD2199  [14]
 LDCM0589  Fragment31 Ramos C41(1.67)  LDD2200  [14]
 LDCM0590  Fragment32 Ramos C41(2.71)  LDD2201  [14]
 LDCM0468  Fragment33 HEK-293T C41(0.93)  LDD1671  [13]
 LDCM0596  Fragment38 Ramos C41(1.18)  LDD2203  [14]
 LDCM0427  Fragment51 HEK-293T C41(0.95)  LDD1631  [13]
 LDCM0614  Fragment56 Ramos C41(1.58)  LDD2205  [14]
 LDCM0569  Fragment7 Ramos C41(1.45)  LDD2186  [14]
 LDCM0022  KB02 HEK-293T C41(1.00)  LDD1492  [13]
 LDCM0023  KB03 Jurkat C16(4.74)  LDD0209  [5]
 LDCM0024  KB05 HMCB C41(3.85)  LDD3312  [15]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C16(0.66)  LDD2121  [2]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C16(0.68)  LDD2089  [2]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C16(0.93)  LDD2093  [2]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C16(1.08)  LDD2099  [2]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C16(1.00)  LDD2107  [2]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C16(0.94)  LDD2109  [2]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C16(0.94)  LDD2111  [2]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C16(1.84)  LDD2119  [2]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C16(0.95)  LDD2123  [2]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C16(0.84)  LDD2125  [2]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C16(1.18)  LDD2127  [2]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C16(1.20)  LDD2129  [2]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C16(0.24)  LDD2135  [2]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C16(1.57)  LDD2136  [2]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C16(0.98)  LDD2137  [2]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C16(1.38)  LDD2144  [2]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C16(0.86)  LDD2146  [2]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C16(0.60)  LDD2150  [2]
 LDCM0628  OTUB2-COV-1 HEK-293T C16(1.06)  LDD2207  [16]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ELL-associated factor 1 (EAF1) EAF family Q96JC9
Probable RNA-binding protein EIF1AD (EIF1AD) EIF1AD family Q8N9N8
General transcription factor IIH subunit 5 (GTF2H5) TFB5 family Q6ZYL4
Protein SREK1IP1 (SREK1IP1) . Q8N9Q2

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Total Synthesis and Target Identification of the Curcusone Diterpenes. J Am Chem Soc. 2021 Mar 24;143(11):4379-4386. doi: 10.1021/jacs.1c00557. Epub 2021 Mar 11.
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
15 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
16 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.