Details of the Target

General Information of Target

Target ID LDTP05017
Target Name Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (GNB1)
Gene Name GNB1
Gene ID 2782
Synonyms
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Transducin beta chain 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYA
MHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNI
CSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTF
TGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNA
FATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDAL
KADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN
Target Bioclass
Transporter and channel
Family
WD repeat G protein beta family
Function
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Uniprot ID
P62873
Ensemble ID
ENST00000378609.9
HGNC ID
HGNC:4396
ChEMBL ID
CHEMBL3883319

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HGC27 SNV: p.Y59H DBIA    Probe Info 
JURKAT SNV: p.T243I Compound 10    Probe Info 
KARPAS422 SNV: p.I80T DBIA    Probe Info 
LNCaP clone FGC SNV: p.Y289H DBIA    Probe Info 
LS180 SNV: p.S316G DBIA    Probe Info 
MOLT4 SNV: p.R214Ter; p.E226K IA-alkyne    Probe Info 
SUDHL4 SNV: p.R219Q DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 38 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		10.47  LDD0402  [1]
N1
 Probe Info  		100.00  LDD0242  [2]
TH211
 Probe Info  		Y85(20.00); Y111(5.65)  LDD0260  [3]
TH216
 Probe Info  		Y59(10.25)  LDD0259  [3]
ONAyne
 Probe Info  		K15(1.93)  LDD0274  [4]
OPA-S-S-alkyne
 Probe Info  		K15(3.12)  LDD3494  [5]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [6]
BTD
 Probe Info  		C25(1.82); C204(1.78)  LDD1700  [7]
Curcusone 37
 Probe Info  		2.28  LDD0188  [8]
AHL-Pu-1
 Probe Info  		C233(2.03)  LDD0170  [9]
DBIA
 Probe Info  		C148(1.02); C149(1.02); C204(0.90)  LDD0078  [10]
5E-2FA
 Probe Info  		H266(0.00); H142(0.00); H62(0.00)  LDD2235  [11]
ATP probe
 Probe Info  		N.A.  LDD0199  [12]
4-Iodoacetamidophenylacetylene
 Probe Info  		C25(0.00); C271(0.00); C204(0.00); C294(0.00)  LDD0038  [13]
IA-alkyne
 Probe Info  		C148(0.00); C204(0.00); C233(0.00); C294(0.00)  LDD0032  [14]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [15]
IPIAA_L
 Probe Info  		C25(0.00); C271(0.00); C233(0.00)  LDD0031  [15]
Lodoacetamide azide
 Probe Info  		C25(0.00); C271(0.00); C148(0.00); C149(0.00)  LDD0037  [13]
ATP probe
 Probe Info  		N.A.  LDD0035  [16]
IPM
 Probe Info  		C25(0.00); C204(0.00)  LDD0025  [17]
JW-RF-010
 Probe Info  		C204(0.00); C25(0.00)  LDD0026  [17]
NAIA_4
 Probe Info  		C25(0.00); C148(0.00); C149(0.00); C204(0.00)  LDD2226  [18]
TFBX
 Probe Info  		N.A.  LDD0027  [17]
WYneO
 Probe Info  		N.A.  LDD0022  [19]
Compound 10
 Probe Info  		C204(0.00); C25(0.00)  LDD2216  [20]
Compound 11
 Probe Info  		N.A.  LDD2213  [20]
NHS
 Probe Info  		N.A.  LDD0010  [19]
PF-06672131
 Probe Info  		N.A.  LDD0017  [21]
STPyne
 Probe Info  		N.A.  LDD0009  [19]
Phosphinate-6
 Probe Info  		C294(0.00); C204(0.00)  LDD0018  [22]
Ox-W18
 Probe Info  		N.A.  LDD2175  [23]
1c-yne
 Probe Info  		K15(0.00); K23(0.00)  LDD0228  [24]
Acrolein
 Probe Info  		C25(0.00); C204(0.00)  LDD0217  [25]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [25]
Crotonaldehyde
 Probe Info  		C204(0.00); C25(0.00); C149(0.00); C148(0.00)  LDD0219  [25]
Methacrolein
 Probe Info  		C25(0.00); C204(0.00)  LDD0218  [25]
AOyne
 Probe Info  		9.50  LDD0443  [26]
NAIA_5
 Probe Info  		C25(0.00); C149(0.00); C148(0.00); C204(0.00)  LDD2223  [18]
PAL-AfBPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		11.91  LDD0472  [27]
FFF probe13
 Probe Info  		9.36  LDD0475  [27]
FFF probe3
 Probe Info  		7.71  LDD0465  [27]
STS-1
 Probe Info  		N.A.  LDD0136  [28]
STS-2
 Probe Info  		N.A.  LDD0138  [28]
DA-2
 Probe Info  		N.A.  LDD0071  [29]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C204(0.63); C148(0.46); C149(0.51)  LDD2142  [7]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C204(0.59); C148(0.63); C25(0.65); C149(0.60)  LDD2112  [7]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C204(0.60)  LDD2095  [7]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C204(0.84); C25(0.50)  LDD2130  [7]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C204(0.98); C25(0.92); C149(1.22)  LDD2117  [7]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C204(1.10); C148(1.71); C25(1.07); C149(1.34)  LDD2152  [7]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C204(1.02); C148(0.91); C25(1.23); C149(2.49)  LDD2103  [7]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C204(0.46)  LDD2132  [7]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C204(0.78)  LDD2131  [7]
 LDCM0025  4SU-RNA DM93 C233(2.03)  LDD0170  [9]
 LDCM0214  AC1 HCT 116 C103(0.62); C114(0.62); C121(0.62); C148(0.79)  LDD0531  [10]
 LDCM0215  AC10 HCT 116 C204(0.97); C25(0.97); C271(0.66); C294(0.84)  LDD0532  [10]
 LDCM0216  AC100 HCT 116 C103(1.19); C114(1.19); C121(1.19); C148(0.92)  LDD0533  [10]
 LDCM0217  AC101 HCT 116 C103(0.90); C114(0.90); C121(0.90); C148(0.77)  LDD0534  [10]
 LDCM0218  AC102 HCT 116 C103(0.85); C114(0.85); C121(0.85); C148(0.91)  LDD0535  [10]
 LDCM0219  AC103 HCT 116 C103(1.07); C114(1.07); C121(1.07); C148(0.68)  LDD0536  [10]
 LDCM0220  AC104 HCT 116 C103(1.15); C114(1.15); C121(1.15); C148(0.89)  LDD0537  [10]
 LDCM0221  AC105 HCT 116 C103(0.75); C114(0.75); C121(0.75); C148(0.67)  LDD0538  [10]
 LDCM0222  AC106 HCT 116 C103(1.31); C114(1.31); C121(1.31); C148(0.57)  LDD0539  [10]
 LDCM0223  AC107 HCT 116 C103(0.98); C114(0.92); C121(1.03); C148(0.66)  LDD0540  [10]
 LDCM0224  AC108 HCT 116 C103(0.73); C114(0.76); C121(0.74); C148(0.69)  LDD0541  [10]
 LDCM0225  AC109 HCT 116 C103(0.73); C114(0.75); C121(0.66); C148(0.92)  LDD0542  [10]
 LDCM0226  AC11 HCT 116 C204(0.99); C25(1.03); C271(0.56); C294(0.81)  LDD0543  [10]
 LDCM0227  AC110 HCT 116 C103(0.90); C114(0.88); C121(0.96); C148(0.74)  LDD0544  [10]
 LDCM0228  AC111 HCT 116 C103(0.63); C114(0.62); C121(0.65); C148(0.71)  LDD0545  [10]
 LDCM0229  AC112 HCT 116 C103(0.86); C114(0.80); C121(0.86); C148(0.73)  LDD0546  [10]
 LDCM0230  AC113 HCT 116 C204(1.29); C271(1.16); C294(1.14)  LDD0547  [10]
 LDCM0231  AC114 HCT 116 C204(1.15); C271(0.99); C294(1.06)  LDD0548  [10]
 LDCM0232  AC115 HCT 116 C204(1.11); C271(1.23); C294(0.93)  LDD0549  [10]
 LDCM0233  AC116 HCT 116 C204(1.19); C271(1.32); C294(1.06)  LDD0550  [10]
 LDCM0234  AC117 HCT 116 C204(1.17); C271(1.11); C294(1.25)  LDD0551  [10]
 LDCM0235  AC118 HCT 116 C204(1.15); C271(1.04); C294(1.30)  LDD0552  [10]
 LDCM0236  AC119 HCT 116 C204(1.18); C271(0.97); C294(1.00)  LDD0553  [10]
 LDCM0237  AC12 HCT 116 C204(1.13); C25(1.17); C271(0.55); C294(0.98)  LDD0554  [10]
 LDCM0238  AC120 HCT 116 C204(1.20); C271(1.31); C294(1.06)  LDD0555  [10]
 LDCM0239  AC121 HCT 116 C204(1.12); C271(1.01); C294(1.25)  LDD0556  [10]
 LDCM0240  AC122 HCT 116 C204(1.05); C271(0.87); C294(0.94)  LDD0557  [10]
 LDCM0241  AC123 HCT 116 C204(1.10); C271(0.93); C294(1.00)  LDD0558  [10]
 LDCM0242  AC124 HCT 116 C204(1.13); C271(0.99); C294(1.32)  LDD0559  [10]
 LDCM0243  AC125 HCT 116 C204(1.07); C271(1.42); C294(1.14)  LDD0560  [10]
 LDCM0244  AC126 HCT 116 C204(1.25); C271(1.19); C294(0.98)  LDD0561  [10]
 LDCM0245  AC127 HCT 116 C204(1.05); C271(1.16); C294(0.86)  LDD0562  [10]
 LDCM0246  AC128 HCT 116 C103(0.65); C114(0.65); C121(0.65); C148(0.62)  LDD0563  [10]
 LDCM0247  AC129 HCT 116 C103(1.68); C114(1.68); C121(1.68); C148(0.74)  LDD0564  [10]
 LDCM0249  AC130 HCT 116 C103(0.77); C114(0.77); C121(0.77); C148(0.60)  LDD0566  [10]
 LDCM0250  AC131 HCT 116 C103(0.91); C114(0.91); C121(0.91); C148(0.88)  LDD0567  [10]
 LDCM0251  AC132 HCT 116 C103(0.62); C114(0.62); C121(0.62); C148(0.69)  LDD0568  [10]
 LDCM0252  AC133 HCT 116 C103(0.69); C114(0.69); C121(0.69); C148(0.73)  LDD0569  [10]
 LDCM0253  AC134 HCT 116 C103(0.94); C114(0.94); C121(0.94); C148(0.65)  LDD0570  [10]
 LDCM0254  AC135 HCT 116 C103(0.53); C114(0.53); C121(0.53); C148(0.59)  LDD0571  [10]
 LDCM0255  AC136 HCT 116 C103(0.59); C114(0.59); C121(0.59); C148(0.79)  LDD0572  [10]
 LDCM0256  AC137 HCT 116 C103(0.75); C114(0.75); C121(0.75); C148(0.74)  LDD0573  [10]
 LDCM0257  AC138 HCT 116 C103(0.61); C114(0.61); C121(0.61); C148(0.63)  LDD0574  [10]
 LDCM0258  AC139 HCT 116 C103(0.76); C114(0.76); C121(0.76); C148(0.55)  LDD0575  [10]
 LDCM0259  AC14 HCT 116 C204(0.89); C25(0.95); C271(0.77); C294(0.77)  LDD0576  [10]
 LDCM0260  AC140 HCT 116 C103(0.88); C114(0.88); C121(0.88); C148(0.52)  LDD0577  [10]
 LDCM0261  AC141 HCT 116 C103(0.67); C114(0.67); C121(0.67); C148(0.55)  LDD0578  [10]
 LDCM0262  AC142 HCT 116 C103(0.78); C114(0.78); C121(0.78); C148(0.71)  LDD0579  [10]
 LDCM0263  AC143 HCT 116 C103(1.25); C114(1.25); C148(0.93); C149(0.93)  LDD0580  [10]
 LDCM0264  AC144 HCT 116 C149(0.80); C148(0.82); C204(0.86); C103(1.49)  LDD0581  [10]
 LDCM0265  AC145 HCT 116 C148(0.83); C149(0.90); C204(0.93); C271(1.32)  LDD0582  [10]
 LDCM0266  AC146 HCT 116 C204(0.79); C148(0.89); C103(0.89); C114(0.89)  LDD0583  [10]
 LDCM0267  AC147 HCT 116 C149(0.80); C204(0.84); C148(0.88); C103(1.17)  LDD0584  [10]
 LDCM0268  AC148 HCT 116 C103(0.49); C114(0.49); C148(0.66); C204(0.78)  LDD0585  [10]
 LDCM0269  AC149 HCT 116 C204(0.69); C148(0.70); C103(0.82); C114(0.82)  LDD0586  [10]
 LDCM0270  AC15 HCT 116 C271(0.86); C294(0.89); C204(1.02); C25(1.02)  LDD0587  [10]
 LDCM0271  AC150 HCT 116 C148(0.85); C149(0.88); C204(0.97); C271(1.12)  LDD0588  [10]
 LDCM0272  AC151 HCT 116 C149(0.92); C204(0.92); C148(0.99); C103(1.21)  LDD0589  [10]
 LDCM0273  AC152 HCT 116 C148(0.72); C204(0.82); C149(0.84); C103(1.08)  LDD0590  [10]
 LDCM0274  AC153 HCT 116 C103(0.42); C114(0.42); C204(0.54); C148(0.61)  LDD0591  [10]
 LDCM0621  AC154 HCT 116 C103(0.96); C114(0.96); C148(0.96); C149(0.75)  LDD2158  [10]
 LDCM0622  AC155 HCT 116 C103(1.33); C114(1.33); C148(0.90); C149(0.95)  LDD2159  [10]
 LDCM0623  AC156 HCT 116 C103(1.44); C114(1.44); C148(1.08); C149(0.96)  LDD2160  [10]
 LDCM0624  AC157 HCT 116 C103(2.61); C114(2.61); C148(0.90); C149(0.99)  LDD2161  [10]
 LDCM0276  AC17 HCT 116 C204(1.06); C271(1.14); C294(1.39)  LDD0593  [10]
 LDCM0277  AC18 HCT 116 C294(1.07); C204(1.15); C271(1.15)  LDD0594  [10]
 LDCM0278  AC19 HCT 116 C204(1.08); C294(1.09); C271(1.15)  LDD0595  [10]
 LDCM0279  AC2 HCT 116 C103(0.83); C114(0.83); C121(0.83); C204(1.03)  LDD0596  [10]
 LDCM0280  AC20 HCT 116 C204(0.91); C271(0.94); C294(1.17)  LDD0597  [10]
 LDCM0281  AC21 HCT 116 C204(0.95); C271(0.96); C294(1.13)  LDD0598  [10]
 LDCM0282  AC22 HCT 116 C271(0.95); C204(0.96); C294(1.46)  LDD0599  [10]
 LDCM0283  AC23 HCT 116 C204(0.73); C271(0.87); C294(0.88)  LDD0600  [10]
 LDCM0284  AC24 HCT 116 C204(1.10); C271(1.11); C294(1.33)  LDD0601  [10]
 LDCM0285  AC25 HCT 116 C148(0.88); C271(0.94); C25(1.02)  LDD0602  [10]
 LDCM0286  AC26 HCT 116 C148(0.72); C271(0.89); C25(1.24)  LDD0603  [10]
 LDCM0287  AC27 HCT 116 C148(0.75); C271(0.99); C25(1.02)  LDD0604  [10]
 LDCM0288  AC28 HCT 116 C148(0.58); C25(0.88); C271(0.90)  LDD0605  [10]
 LDCM0289  AC29 HCT 116 C148(0.55); C25(0.74); C271(1.16)  LDD0606  [10]
 LDCM0290  AC3 HCT 116 C103(0.71); C114(0.71); C121(0.71); C204(0.99)  LDD0607  [10]
 LDCM0291  AC30 HCT 116 C148(0.55); C25(0.69); C271(1.49)  LDD0608  [10]
 LDCM0292  AC31 HCT 116 C148(0.76); C25(1.00); C271(1.27)  LDD0609  [10]
 LDCM0293  AC32 HCT 116 C148(0.57); C25(0.69); C271(1.10)  LDD0610  [10]
 LDCM0294  AC33 HCT 116 C148(0.84); C25(0.97); C271(1.08)  LDD0611  [10]
 LDCM0295  AC34 HCT 116 C148(0.66); C25(0.96); C271(1.22)  LDD0612  [10]
 LDCM0296  AC35 HEK-293T C25(0.99)  LDD0894  [10]
 LDCM0297  AC36 HEK-293T C25(0.99)  LDD0895  [10]
 LDCM0298  AC37 HEK-293T C25(0.88)  LDD0896  [10]
 LDCM0299  AC38 HEK-293T C25(1.12)  LDD0897  [10]
 LDCM0300  AC39 HEK-293T C25(1.38)  LDD0898  [10]
 LDCM0301  AC4 HCT 116 C103(0.69); C114(0.69); C121(0.69); C148(0.98)  LDD0618  [10]
 LDCM0302  AC40 HEK-293T C25(0.84)  LDD0900  [10]
 LDCM0303  AC41 HEK-293T C25(1.26)  LDD0901  [10]
 LDCM0304  AC42 HEK-293T C25(1.23)  LDD0902  [10]
 LDCM0305  AC43 HEK-293T C25(1.17)  LDD0903  [10]
 LDCM0306  AC44 HEK-293T C25(1.12)  LDD0904  [10]
 LDCM0307  AC45 HEK-293T C25(1.31)  LDD0905  [10]
 LDCM0308  AC46 HCT 116 C204(0.78); C148(0.90); C149(0.90); C294(0.94)  LDD0625  [10]
 LDCM0309  AC47 HCT 116 C294(0.76); C148(0.84); C149(0.84); C204(0.95)  LDD0626  [10]
 LDCM0310  AC48 HCT 116 C148(0.51); C149(0.51); C294(0.72); C204(0.80)  LDD0627  [10]
 LDCM0311  AC49 HCT 116 C294(0.60); C204(0.68); C148(0.85); C149(0.85)  LDD0628  [10]
 LDCM0312  AC5 HCT 116 C103(0.52); C114(0.52); C121(0.52); C204(1.00)  LDD0629  [10]
 LDCM0313  AC50 HCT 116 C294(0.57); C148(0.64); C149(0.64); C204(0.68)  LDD0630  [10]
 LDCM0314  AC51 HCT 116 C148(0.68); C149(0.68); C271(0.70); C204(0.72)  LDD0631  [10]
 LDCM0315  AC52 HCT 116 C204(0.79); C294(0.91); C271(0.92); C148(1.02)  LDD0632  [10]
 LDCM0316  AC53 HCT 116 C294(0.74); C148(0.81); C149(0.81); C204(0.91)  LDD0633  [10]
 LDCM0317  AC54 HCT 116 C204(0.78); C294(0.81); C148(0.89); C149(0.89)  LDD0634  [10]
 LDCM0318  AC55 HCT 116 C148(0.49); C149(0.49); C294(0.51); C204(1.14)  LDD0635  [10]
 LDCM0319  AC56 HCT 116 C294(0.21); C148(0.22); C149(0.22); C204(0.84)  LDD0636  [10]
 LDCM0320  AC57 HCT 116 C148(0.67); C149(0.67); C103(0.72); C121(0.72)  LDD0637  [10]
 LDCM0321  AC58 HCT 116 C148(0.49); C149(0.49); C204(0.60); C103(1.30)  LDD0638  [10]
 LDCM0322  AC59 HCT 116 C204(0.70); C148(0.71); C149(0.71); C103(0.89)  LDD0639  [10]
 LDCM0323  AC6 HCT 116 C271(0.85); C294(0.87); C204(0.91); C25(0.98)  LDD0640  [10]
 LDCM0324  AC60 HCT 116 C204(0.60); C148(0.70); C149(0.70); C103(1.39)  LDD0641  [10]
 LDCM0325  AC61 HCT 116 C103(0.46); C121(0.46); C204(0.54); C148(0.55)  LDD0642  [10]
 LDCM0326  AC62 HCT 116 C148(0.48); C149(0.48); C204(0.57); C103(0.90)  LDD0643  [10]
 LDCM0327  AC63 HCT 116 C148(0.74); C149(0.74); C103(0.81); C121(0.81)  LDD0644  [10]
 LDCM0328  AC64 HCT 116 C148(0.52); C149(0.52); C204(0.56); C103(0.64)  LDD0645  [10]
 LDCM0329  AC65 HCT 116 C103(0.54); C121(0.54); C148(0.57); C149(0.57)  LDD0646  [10]
 LDCM0330  AC66 HCT 116 C148(0.58); C149(0.58); C103(0.66); C121(0.66)  LDD0647  [10]
 LDCM0331  AC67 HCT 116 C103(0.18); C121(0.18); C148(0.21); C149(0.21)  LDD0648  [10]
 LDCM0332  AC68 HCT 116 C148(0.85); C149(0.85); C25(0.92); C204(1.09)  LDD0649  [10]
 LDCM0333  AC69 HCT 116 C25(0.55); C204(0.71); C148(0.75); C149(0.75)  LDD0650  [10]
 LDCM0334  AC7 HCT 116 C271(0.70); C204(0.95); C294(0.99); C25(1.07)  LDD0651  [10]
 LDCM0335  AC70 HCT 116 C25(0.44); C204(0.60); C148(0.73); C149(0.73)  LDD0652  [10]
 LDCM0336  AC71 HCT 116 C148(0.83); C149(0.83); C25(1.09); C204(1.14)  LDD0653  [10]
 LDCM0337  AC72 HCT 116 C25(0.77); C204(0.85); C148(0.93); C149(0.93)  LDD0654  [10]
 LDCM0338  AC73 HCT 116 C25(0.43); C204(0.46); C148(0.66); C149(0.66)  LDD0655  [10]
 LDCM0339  AC74 HCT 116 C25(0.35); C204(0.38); C148(0.63); C149(0.63)  LDD0656  [10]
 LDCM0340  AC75 HCT 116 C25(0.23); C204(0.28); C148(0.46); C149(0.46)  LDD0657  [10]
 LDCM0341  AC76 HCT 116 C148(0.85); C149(0.85); C25(0.86); C204(1.04)  LDD0658  [10]
 LDCM0342  AC77 HCT 116 C148(0.77); C149(0.77); C25(0.78); C204(0.97)  LDD0659  [10]
 LDCM0343  AC78 HCT 116 C148(0.72); C149(0.72); C25(0.79); C204(0.91)  LDD0660  [10]
 LDCM0344  AC79 HCT 116 C148(0.84); C149(0.84); C204(0.94); C25(1.09)  LDD0661  [10]
 LDCM0345  AC8 HCT 116 C204(0.83); C271(0.87); C294(0.92); C25(0.95)  LDD0662  [10]
 LDCM0346  AC80 HCT 116 C148(0.83); C149(0.83); C204(0.87); C25(0.93)  LDD0663  [10]
 LDCM0347  AC81 HCT 116 C25(0.82); C148(1.15); C149(1.15); C204(1.30)  LDD0664  [10]
 LDCM0348  AC82 HCT 116 C25(0.13); C204(0.19); C148(0.40); C149(0.40)  LDD0665  [10]
 LDCM0349  AC83 HCT 116 C148(0.66); C149(0.66); C204(0.81)  LDD0666  [10]
 LDCM0350  AC84 HCT 116 C148(0.79); C149(0.79); C204(0.86)  LDD0667  [10]
 LDCM0351  AC85 HCT 116 C148(0.82); C149(0.82); C204(1.01)  LDD0668  [10]
 LDCM0352  AC86 HCT 116 C148(0.82); C149(0.82); C204(1.08)  LDD0669  [10]
 LDCM0353  AC87 HCT 116 C148(0.92); C149(0.92); C204(1.09)  LDD0670  [10]
 LDCM0354  AC88 HCT 116 C148(0.91); C149(0.91); C204(0.93)  LDD0671  [10]
 LDCM0355  AC89 HCT 116 C148(0.75); C149(0.75); C204(0.96)  LDD0672  [10]
 LDCM0357  AC90 HCT 116 C148(0.75); C149(0.75); C204(1.15)  LDD0674  [10]
 LDCM0358  AC91 HCT 116 C148(0.65); C149(0.65); C204(0.89)  LDD0675  [10]
 LDCM0359  AC92 HCT 116 C148(0.72); C149(0.72); C204(0.97)  LDD0676  [10]
 LDCM0360  AC93 HCT 116 C148(0.94); C149(0.94); C204(1.13)  LDD0677  [10]
 LDCM0361  AC94 HCT 116 C148(0.84); C149(0.84); C204(0.97)  LDD0678  [10]
 LDCM0362  AC95 HCT 116 C148(0.69); C149(0.69); C204(1.05)  LDD0679  [10]
 LDCM0363  AC96 HCT 116 C148(0.77); C149(0.77); C204(0.95)  LDD0680  [10]
 LDCM0364  AC97 HCT 116 C148(0.75); C149(0.75); C204(0.89)  LDD0681  [10]
 LDCM0365  AC98 HCT 116 C25(0.09); C103(0.10); C114(0.10); C121(0.10)  LDD0682  [10]
 LDCM0366  AC99 HCT 116 C294(0.74); C204(0.81); C103(0.85); C114(0.85)  LDD0683  [10]
 LDCM0545  Acetamide MDA-MB-231 C204(0.68); C25(0.44)  LDD2138  [7]
 LDCM0520  AKOS000195272 MDA-MB-231 C148(1.08); C149(1.05)  LDD2113  [7]
 LDCM0248  AKOS034007472 HCT 116 C204(1.24); C25(1.22); C271(0.67); C294(0.96)  LDD0565  [10]
 LDCM0356  AKOS034007680 HCT 116 C271(0.75); C294(0.97); C204(1.06); C25(1.25)  LDD0673  [10]
 LDCM0275  AKOS034007705 HCT 116 C294(0.63); C25(0.87); C271(0.88); C204(0.93)  LDD0592  [10]
 LDCM0156  Aniline NCI-H1299 11.46  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C148(1.02); C149(1.02); C204(0.90)  LDD0078  [10]
 LDCM0498  BS-3668 MDA-MB-231 C204(0.75); C25(0.60)  LDD2091  [7]
 LDCM0108  Chloroacetamide HeLa C25(0.00); C204(0.00)  LDD0222  [25]
 LDCM0632  CL-Sc Hep-G2 C204(0.65)  LDD2227  [18]
 LDCM0367  CL1 HCT 116 C148(0.66); C149(0.66); C25(0.72); C204(0.97)  LDD0684  [10]
 LDCM0368  CL10 HCT 116 C25(0.46); C103(0.51); C114(0.51); C121(0.51)  LDD0685  [10]
 LDCM0369  CL100 HCT 116 C103(0.79); C114(0.79); C121(0.79); C148(0.92)  LDD0686  [10]
 LDCM0370  CL101 HCT 116 C294(0.74); C271(0.80); C25(0.87); C204(1.01)  LDD0687  [10]
 LDCM0371  CL102 HCT 116 C271(0.62); C294(0.88); C25(1.04); C204(1.22)  LDD0688  [10]
 LDCM0372  CL103 HCT 116 C271(0.58); C294(0.68); C25(0.78); C204(0.81)  LDD0689  [10]
 LDCM0373  CL104 HCT 116 C271(0.73); C204(0.85); C294(0.91); C25(1.00)  LDD0690  [10]
 LDCM0374  CL105 HCT 116 C294(0.85); C204(0.96); C271(0.98)  LDD0691  [10]
 LDCM0375  CL106 HCT 116 C294(0.49); C204(0.84); C271(1.42)  LDD0692  [10]
 LDCM0376  CL107 HCT 116 C294(0.94); C204(0.95); C271(1.20)  LDD0693  [10]
 LDCM0377  CL108 HCT 116 C294(0.90); C204(1.01); C271(1.58)  LDD0694  [10]
 LDCM0378  CL109 HCT 116 C204(0.78); C294(0.80); C271(1.09)  LDD0695  [10]
 LDCM0379  CL11 HCT 116 C148(0.48); C149(0.48); C103(0.62); C114(0.62)  LDD0696  [10]
 LDCM0380  CL110 HCT 116 C294(0.71); C204(0.80); C271(1.22)  LDD0697  [10]
 LDCM0381  CL111 HCT 116 C204(0.75); C294(0.75); C271(1.07)  LDD0698  [10]
 LDCM0382  CL112 HCT 116 C25(0.73); C148(0.85); C271(0.93)  LDD0699  [10]
 LDCM0383  CL113 HCT 116 C148(0.63); C25(0.75); C271(1.17)  LDD0700  [10]
 LDCM0384  CL114 HCT 116 C148(0.65); C25(0.65); C271(1.29)  LDD0701  [10]
 LDCM0385  CL115 HCT 116 C148(0.74); C25(0.77); C271(1.13)  LDD0702  [10]
 LDCM0386  CL116 HCT 116 C148(0.68); C271(1.01); C25(1.08)  LDD0703  [10]
 LDCM0387  CL117 HEK-293T C25(0.94)  LDD0985  [10]
 LDCM0388  CL118 HEK-293T C25(0.83)  LDD0986  [10]
 LDCM0389  CL119 HEK-293T C25(1.16)  LDD0987  [10]
 LDCM0390  CL12 HCT 116 C148(0.62); C149(0.62); C103(0.71); C114(0.71)  LDD0707  [10]
 LDCM0391  CL120 HEK-293T C25(1.44)  LDD0989  [10]
 LDCM0392  CL121 HCT 116 C294(0.63); C204(0.89); C148(1.16); C149(1.16)  LDD0709  [10]
 LDCM0393  CL122 HCT 116 C148(0.53); C149(0.53); C294(0.54); C204(0.90)  LDD0710  [10]
 LDCM0394  CL123 HCT 116 C294(0.66); C148(0.75); C149(0.75); C204(0.76)  LDD0711  [10]
 LDCM0395  CL124 HCT 116 C294(0.56); C148(0.64); C149(0.64); C204(0.74)  LDD0712  [10]
 LDCM0396  CL125 HCT 116 C148(0.60); C149(0.60); C103(0.78); C121(0.78)  LDD0713  [10]
 LDCM0397  CL126 HCT 116 C204(0.94); C103(1.12); C121(1.12); C148(1.17)  LDD0714  [10]
 LDCM0398  CL127 HCT 116 C204(0.70); C148(0.83); C149(0.83); C103(2.28)  LDD0715  [10]
 LDCM0399  CL128 HCT 116 C103(0.76); C121(0.76); C148(0.79); C149(0.79)  LDD0716  [10]
 LDCM0400  CL13 HCT 116 C25(0.54); C148(0.56); C149(0.56); C103(0.72)  LDD0717  [10]
 LDCM0401  CL14 HCT 116 C25(0.75); C148(0.82); C149(0.82); C103(1.22)  LDD0718  [10]
 LDCM0402  CL15 HCT 116 C25(0.40); C148(0.47); C149(0.47); C204(0.75)  LDD0719  [10]
 LDCM0403  CL16 HCT 116 C204(0.76); C294(0.78)  LDD0720  [10]
 LDCM0404  CL17 HCT 116 C294(0.62); C204(0.71)  LDD0721  [10]
 LDCM0405  CL18 HCT 116 C294(0.62); C204(0.71)  LDD0722  [10]
 LDCM0406  CL19 HCT 116 C294(0.56); C204(0.76)  LDD0723  [10]
 LDCM0407  CL2 HCT 116 C148(0.75); C149(0.75); C25(0.86); C204(0.98)  LDD0724  [10]
 LDCM0408  CL20 HCT 116 C294(0.64); C204(0.69)  LDD0725  [10]
 LDCM0409  CL21 HCT 116 C294(0.41); C204(0.49)  LDD0726  [10]
 LDCM0410  CL22 HCT 116 C294(0.26); C204(0.31)  LDD0727  [10]
 LDCM0411  CL23 HCT 116 C294(0.64); C204(0.76)  LDD0728  [10]
 LDCM0412  CL24 HCT 116 C204(0.62); C294(0.65)  LDD0729  [10]
 LDCM0413  CL25 HCT 116 C204(0.60); C294(0.60)  LDD0730  [10]
 LDCM0414  CL26 HCT 116 C204(0.70); C294(0.69)  LDD0731  [10]
 LDCM0415  CL27 HCT 116 C204(0.83); C294(0.78)  LDD0732  [10]
 LDCM0416  CL28 HCT 116 C204(0.57); C294(0.59)  LDD0733  [10]
 LDCM0417  CL29 HCT 116 C204(0.59); C294(0.56)  LDD0734  [10]
 LDCM0418  CL3 HCT 116 C103(0.81); C114(0.81); C121(0.81); C148(0.87)  LDD0735  [10]
 LDCM0419  CL30 HCT 116 C204(0.75); C294(0.73)  LDD0736  [10]
 LDCM0420  CL31 HCT 116 C148(0.73); C149(0.73); C204(0.74); C25(0.94)  LDD0737  [10]
 LDCM0421  CL32 HCT 116 C148(0.70); C149(0.70); C204(0.68); C25(0.78)  LDD0738  [10]
 LDCM0422  CL33 HCT 116 C148(0.87); C149(0.87); C204(0.71); C25(0.76)  LDD0739  [10]
 LDCM0423  CL34 HCT 116 C148(0.59); C149(0.59); C204(0.41); C25(0.48)  LDD0740  [10]
 LDCM0424  CL35 HCT 116 C148(0.70); C149(0.70); C204(0.59); C25(0.65)  LDD0741  [10]
 LDCM0425  CL36 HCT 116 C148(0.80); C149(0.80); C204(0.67); C25(0.71)  LDD0742  [10]
 LDCM0426  CL37 HCT 116 C148(0.55); C149(0.55); C204(0.53); C25(0.61)  LDD0743  [10]
 LDCM0428  CL39 HCT 116 C148(0.90); C149(0.90); C204(0.59); C25(0.84)  LDD0745  [10]
 LDCM0429  CL4 HCT 116 C103(0.89); C114(0.89); C121(0.89); C148(1.10)  LDD0746  [10]
 LDCM0430  CL40 HCT 116 C148(0.72); C149(0.72); C204(0.77); C25(0.73)  LDD0747  [10]
 LDCM0431  CL41 HCT 116 C148(0.71); C149(0.71); C204(0.72); C25(0.96)  LDD0748  [10]
 LDCM0432  CL42 HCT 116 C148(0.35); C149(0.35); C204(0.28); C25(0.29)  LDD0749  [10]
 LDCM0433  CL43 HCT 116 C148(0.77); C149(0.77); C204(0.51); C25(0.51)  LDD0750  [10]
 LDCM0434  CL44 HCT 116 C148(0.64); C149(0.64); C204(0.52); C25(0.53)  LDD0751  [10]
 LDCM0435  CL45 HCT 116 C148(0.52); C149(0.52); C204(0.37); C25(0.41)  LDD0752  [10]
 LDCM0436  CL46 HCT 116 C148(0.81); C149(0.81); C204(1.07); C25(0.88)  LDD0753  [10]
 LDCM0437  CL47 HCT 116 C148(0.76); C149(0.76); C204(1.30); C25(0.77)  LDD0754  [10]
 LDCM0438  CL48 HCT 116 C148(0.76); C149(0.76); C204(1.52); C25(0.97)  LDD0755  [10]
 LDCM0439  CL49 HCT 116 C148(0.66); C149(0.66); C204(1.24); C25(1.06)  LDD0756  [10]
 LDCM0440  CL5 HCT 116 C103(1.07); C114(1.07); C121(1.07); C148(0.60)  LDD0757  [10]
 LDCM0441  CL50 HCT 116 C148(0.80); C149(0.80); C204(1.24); C25(0.90)  LDD0758  [10]
 LDCM0442  CL51 HCT 116 C148(0.60); C149(0.60); C204(1.40); C25(1.05)  LDD0759  [10]
 LDCM0443  CL52 HCT 116 C148(0.84); C149(0.84); C204(1.44); C25(0.92)  LDD0760  [10]
 LDCM0444  CL53 HCT 116 C148(1.61); C149(1.61); C204(1.04); C25(0.83)  LDD0761  [10]
 LDCM0445  CL54 HCT 116 C148(0.77); C149(0.77); C204(1.01); C25(0.82)  LDD0762  [10]
 LDCM0446  CL55 HCT 116 C148(1.02); C149(1.02); C204(1.39); C25(0.95)  LDD0763  [10]
 LDCM0447  CL56 HCT 116 C148(1.11); C149(1.11); C204(1.19); C25(0.85)  LDD0764  [10]
 LDCM0448  CL57 HCT 116 C148(0.80); C149(0.80); C204(1.25); C25(0.74)  LDD0765  [10]
 LDCM0449  CL58 HCT 116 C148(0.83); C149(0.83); C204(1.38); C25(1.21)  LDD0766  [10]
 LDCM0450  CL59 HCT 116 C148(0.97); C149(0.97); C204(1.33); C25(1.11)  LDD0767  [10]
 LDCM0451  CL6 HCT 116 C103(0.49); C114(0.49); C121(0.49); C148(0.51)  LDD0768  [10]
 LDCM0452  CL60 HCT 116 C148(0.73); C149(0.73); C204(1.15); C25(0.89)  LDD0769  [10]
 LDCM0453  CL61 HCT 116 C148(1.05); C149(1.05); C204(0.92); C271(1.04)  LDD0770  [10]
 LDCM0454  CL62 HCT 116 C148(0.91); C149(0.91); C204(0.80); C271(0.88)  LDD0771  [10]
 LDCM0455  CL63 HCT 116 C148(0.94); C149(0.94); C204(1.06); C271(0.96)  LDD0772  [10]
 LDCM0456  CL64 HCT 116 C148(0.94); C149(0.94); C204(0.72); C271(0.90)  LDD0773  [10]
 LDCM0457  CL65 HCT 116 C148(1.11); C149(1.11); C204(0.98); C271(0.92)  LDD0774  [10]
 LDCM0458  CL66 HCT 116 C148(0.66); C149(0.66); C204(0.64); C271(0.89)  LDD0775  [10]
 LDCM0459  CL67 HCT 116 C148(1.28); C149(1.28); C204(0.84); C271(0.95)  LDD0776  [10]
 LDCM0460  CL68 HCT 116 C148(1.18); C149(1.18); C204(0.78); C271(1.53)  LDD0777  [10]
 LDCM0461  CL69 HCT 116 C148(0.87); C149(0.87); C204(0.88); C271(1.07)  LDD0778  [10]
 LDCM0462  CL7 HCT 116 C103(0.71); C114(0.71); C121(0.71); C148(0.53)  LDD0779  [10]
 LDCM0463  CL70 HCT 116 C148(1.00); C149(1.00); C204(0.77); C271(1.03)  LDD0780  [10]
 LDCM0464  CL71 HCT 116 C148(0.97); C149(0.97); C204(0.84); C271(0.99)  LDD0781  [10]
 LDCM0465  CL72 HCT 116 C148(1.14); C149(1.14); C204(1.06); C271(1.04)  LDD0782  [10]
 LDCM0466  CL73 HCT 116 C148(0.92); C149(0.92); C204(0.74); C271(1.09)  LDD0783  [10]
 LDCM0467  CL74 HCT 116 C148(0.93); C149(0.93); C204(0.80); C271(0.96)  LDD0784  [10]
 LDCM0469  CL76 HCT 116 C103(0.82); C114(0.82); C121(0.82); C148(0.94)  LDD0786  [10]
 LDCM0470  CL77 HCT 116 C103(0.96); C114(0.96); C121(0.96); C148(1.12)  LDD0787  [10]
 LDCM0471  CL78 HCT 116 C103(0.60); C114(0.60); C121(0.60); C148(0.78)  LDD0788  [10]
 LDCM0472  CL79 HCT 116 C103(0.94); C114(0.94); C121(0.94); C148(1.06)  LDD0789  [10]
 LDCM0473  CL8 HCT 116 C103(0.58); C114(0.58); C121(0.58); C148(0.65)  LDD0790  [10]
 LDCM0474  CL80 HCT 116 C103(1.27); C114(1.27); C121(1.27); C148(1.03)  LDD0791  [10]
 LDCM0475  CL81 HCT 116 C103(1.02); C114(1.02); C121(1.02); C148(1.14)  LDD0792  [10]
 LDCM0476  CL82 HCT 116 C103(0.54); C114(0.54); C121(0.54); C148(1.00)  LDD0793  [10]
 LDCM0477  CL83 HCT 116 C103(0.87); C114(0.87); C121(0.87); C148(1.06)  LDD0794  [10]
 LDCM0478  CL84 HCT 116 C103(0.79); C114(0.79); C121(0.79); C148(0.80)  LDD0795  [10]
 LDCM0479  CL85 HCT 116 C103(0.93); C114(0.93); C121(0.93); C148(0.91)  LDD0796  [10]
 LDCM0480  CL86 HCT 116 C103(0.82); C114(0.82); C121(0.82); C148(1.02)  LDD0797  [10]
 LDCM0481  CL87 HCT 116 C103(1.03); C114(1.03); C121(1.03); C148(0.72)  LDD0798  [10]
 LDCM0482  CL88 HCT 116 C103(0.87); C114(0.87); C121(0.87); C148(1.19)  LDD0799  [10]
 LDCM0483  CL89 HCT 116 C103(0.51); C114(0.51); C121(0.51); C148(1.10)  LDD0800  [10]
 LDCM0484  CL9 HCT 116 C103(1.03); C114(1.03); C121(1.03); C148(0.57)  LDD0801  [10]
 LDCM0485  CL90 HCT 116 C103(0.87); C114(0.87); C121(0.87); C148(1.12)  LDD0802  [10]
 LDCM0486  CL91 HCT 116 C103(0.46); C114(0.46); C121(0.46); C148(0.84)  LDD0803  [10]
 LDCM0487  CL92 HCT 116 C103(0.90); C114(0.90); C121(0.90); C148(1.00)  LDD0804  [10]
 LDCM0488  CL93 HCT 116 C103(0.74); C114(0.74); C121(0.74); C148(0.75)  LDD0805  [10]
 LDCM0489  CL94 HCT 116 C103(0.80); C114(0.80); C121(0.80); C148(0.88)  LDD0806  [10]
 LDCM0490  CL95 HCT 116 C103(0.63); C114(0.63); C121(0.63); C148(1.03)  LDD0807  [10]
 LDCM0491  CL96 HCT 116 C103(0.52); C114(0.52); C121(0.52); C148(0.95)  LDD0808  [10]
 LDCM0492  CL97 HCT 116 C103(1.05); C114(1.05); C121(1.05); C148(0.69)  LDD0809  [10]
 LDCM0493  CL98 HCT 116 C103(0.54); C114(0.54); C121(0.54); C148(0.86)  LDD0810  [10]
 LDCM0494  CL99 HCT 116 C103(0.58); C114(0.58); C121(0.58); C148(0.80)  LDD0811  [10]
 LDCM0033  Curcusone1d MCF-7 2.28  LDD0188  [8]
 LDCM0495  E2913 HEK-293T C204(0.96); C25(1.07); C271(0.96); C294(0.96)  LDD1698  [30]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C149(2.65); C148(1.91); C204(1.65)  LDD1702  [7]
 LDCM0625  F8 Ramos C25(0.67); C204(0.62)  LDD2187  [31]
 LDCM0572  Fragment10 Ramos C25(0.71); C204(0.83)  LDD2189  [31]
 LDCM0573  Fragment11 Ramos C25(0.50); C204(0.88)  LDD2190  [31]
 LDCM0574  Fragment12 Ramos C25(0.72); C204(1.01)  LDD2191  [31]
 LDCM0575  Fragment13 Ramos C25(0.85); C204(0.91)  LDD2192  [31]
 LDCM0576  Fragment14 Ramos C25(0.78)  LDD2193  [31]
 LDCM0579  Fragment20 Ramos C25(0.67); C204(0.83)  LDD2194  [31]
 LDCM0580  Fragment21 Ramos C25(1.04); C204(0.98)  LDD2195  [31]
 LDCM0582  Fragment23 Ramos C25(1.13); C204(1.09)  LDD2196  [31]
 LDCM0578  Fragment27 Ramos C25(1.01); C204(0.77)  LDD2197  [31]
 LDCM0586  Fragment28 Ramos C25(0.67); C204(1.09)  LDD2198  [31]
 LDCM0588  Fragment30 Ramos C25(0.97); C204(1.06)  LDD2199  [31]
 LDCM0589  Fragment31 Ramos C25(1.01); C204(1.10)  LDD2200  [31]
 LDCM0590  Fragment32 Ramos C25(0.70); C204(0.78)  LDD2201  [31]
 LDCM0468  Fragment33 HCT 116 C148(0.88); C149(0.88); C204(0.84); C271(1.01)  LDD0785  [10]
 LDCM0596  Fragment38 Ramos C25(0.94); C204(0.89)  LDD2203  [31]
 LDCM0566  Fragment4 Ramos C25(0.82); C204(0.82)  LDD2184  [31]
 LDCM0427  Fragment51 HCT 116 C148(0.44); C149(0.44); C204(0.40); C25(0.45)  LDD0744  [10]
 LDCM0610  Fragment52 Ramos C25(0.99); C204(1.15)  LDD2204  [31]
 LDCM0614  Fragment56 Ramos C25(1.10); C204(0.99)  LDD2205  [31]
 LDCM0569  Fragment7 Ramos C25(0.74); C204(1.01)  LDD2186  [31]
 LDCM0571  Fragment9 Ramos C25(0.66); C204(0.83)  LDD2188  [31]
 LDCM0107  IAA HeLa C25(0.00); C204(0.00); C149(0.00); C148(0.00)  LDD0221  [25]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [6]
 LDCM0022  KB02 HCT 116 C204(1.80); C271(1.17)  LDD0080  [10]
 LDCM0023  KB03 HCT 116 C204(2.15); C271(1.26)  LDD0081  [10]
 LDCM0024  KB05 HCT 116 C204(1.98); C271(1.35)  LDD0082  [10]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C204(1.39)  LDD2102  [7]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C204(0.82)  LDD2121  [7]
 LDCM0109  NEM HeLa N.A.  LDD0224  [25]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C204(0.75); C25(0.51); C149(1.53)  LDD2089  [7]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C204(0.79)  LDD2090  [7]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C148(1.16)  LDD2092  [7]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C204(1.12); C148(1.74); C25(0.93)  LDD2093  [7]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C25(2.27); C149(1.83)  LDD2094  [7]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C25(0.18)  LDD2096  [7]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C148(1.05); C149(0.94)  LDD2097  [7]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C204(0.82); C149(1.35)  LDD2098  [7]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C204(1.06); C148(0.99); C149(1.27)  LDD2099  [7]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C204(0.41); C148(0.95); C25(0.41)  LDD2100  [7]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C204(1.02); C148(1.51); C149(1.74)  LDD2101  [7]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C204(0.68); C148(0.60); C25(0.35); C149(0.48)  LDD2104  [7]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C204(1.57); C25(2.11); C149(2.56)  LDD2105  [7]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C204(0.65); C149(0.41)  LDD2106  [7]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C204(0.96); C148(1.12); C25(0.95)  LDD2107  [7]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C204(0.45); C148(0.56); C25(0.45); C149(0.58)  LDD2108  [7]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C204(0.77); C148(0.78); C149(1.06)  LDD2109  [7]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C204(1.34); C148(0.53); C149(0.96)  LDD2110  [7]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C148(1.21); C25(0.93); C149(1.28)  LDD2111  [7]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C204(1.15); C148(0.59); C25(0.87); C149(0.60)  LDD2114  [7]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C148(0.57); C25(0.36); C149(0.90)  LDD2115  [7]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C25(0.45)  LDD2118  [7]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C204(1.67); C148(1.85)  LDD2119  [7]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C204(0.96); C148(0.96); C25(0.87)  LDD2120  [7]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C25(0.37)  LDD2122  [7]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C204(1.17); C148(0.93); C25(0.72); C149(1.09)  LDD2123  [7]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C25(0.32)  LDD2124  [7]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C204(0.92); C25(0.67); C149(0.89)  LDD2125  [7]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C148(0.21); C25(0.26)  LDD2126  [7]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C204(0.91); C148(0.95); C25(0.81); C149(0.99)  LDD2127  [7]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C148(1.16)  LDD2128  [7]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C204(1.12); C148(1.16); C25(1.16); C149(1.13)  LDD2129  [7]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C148(0.84)  LDD2133  [7]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C148(0.88); C25(0.47); C149(0.81)  LDD2134  [7]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C204(1.38); C148(1.11); C25(1.32); C149(1.28)  LDD2135  [7]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C204(1.04); C25(1.15)  LDD2136  [7]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C204(0.89); C148(0.97); C25(0.76)  LDD2137  [7]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C25(1.82); C204(1.78)  LDD1700  [7]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C204(0.78); C148(1.47); C149(1.46)  LDD2140  [7]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C204(0.37); C148(0.64); C25(0.50)  LDD2141  [7]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C204(1.04); C148(0.58); C25(0.99)  LDD2143  [7]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C204(2.10); C148(1.99); C25(2.78); C149(2.01)  LDD2144  [7]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C204(0.34); C149(0.74)  LDD2145  [7]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C204(1.00); C148(1.40); C149(1.34)  LDD2146  [7]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C204(1.45); C25(1.88)  LDD2147  [7]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C148(0.57); C25(0.57); C149(0.75)  LDD2148  [7]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C25(0.53)  LDD2149  [7]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C204(0.58); C25(0.37)  LDD2150  [7]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C204(1.88); C148(3.74)  LDD2153  [7]
 LDCM0627  NUDT7-COV-1 HEK-293T C204(1.10)  LDD2206  [32]
 LDCM0628  OTUB2-COV-1 HEK-293T C204(1.49)  LDD2207  [32]
 LDCM0131  RA190 MM1.R C204(1.84); C294(1.70); C25(1.40); C233(1.22)  LDD0304  [33]
 LDCM0021  THZ1 HCT 116 C25(1.13); C294(0.87); C148(1.06); C149(1.06)  LDD2173  [10]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein disulfide-isomerase (P4HB) Protein disulfide isomerase family P07237
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 (GNG2) G protein gamma family P59768
Neutrophil cytosol factor 2 (NCF2) NCF2/NOXA1 family P19878
Protein VAC14 homolog (VAC14) VAC14 family Q08AM6

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
6 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 Total Synthesis and Target Identification of the Curcusone Diterpenes. J Am Chem Soc. 2021 Mar 24;143(11):4379-4386. doi: 10.1021/jacs.1c00557. Epub 2021 Mar 11.
9 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
10 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
11 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
12 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
13 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
14 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
15 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
16 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
17 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
18 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
19 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
20 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
21 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
22 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
23 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
24 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
25 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
26 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
27 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
28 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
29 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
30 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
31 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
32 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
33 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.