Details of the Target

General Information of Target

Target ID LDTP09624
Target Name Protein POF1B (POF1B)
Gene Name POF1B
Gene ID 79983
Synonyms
Protein POF1B; Premature ovarian failure protein 1B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSSSYWSETSSSSCGTQQLPEVLQCQPQHYHCYHQSSQAQQPPEKNVVYERVRTYSGPMN
KVVQALDPFNSREVLSPLKTTSSYQNLVWSDHSQELHSPTLKISTCAPSTLHITQNTEQE
LHSPTVKLTTYPQTTIRKYVVQNPEQEPLSQFLRGSHFFPGNNVIYEKTIRKVEKLNTDQ
GCHPQAQCHHHIIQQPQVIHSAHWQQPDSSQQIQAITGNNPISTHIGNELCHSGSSQICE
QVIIQDDGPEKLDPRYFGELLADLSRKNTDLYHCLLEHLQRIGGSKQDFESTDESEDIES
LIPKGLSEFTKQQIRYILQMRGMSDKSLRLVLSTFSNIREELGHLQNDMTSLENDKMRLE
KDLSFKDTQLKEYEELLASVRANNHQQQQGLQDSSSKCQALEENNLSLRHTLSDMEYRLK
ELEYCKRNLEQENQNLRMQVSETCTGPMLQAKMDEIGNHYTEMVKNLRMEKDREICRLRS
QLNQYHKDVSKREGSCSDFQFKLHELTSLLEEKDSLIKRQSEELSKLRQEIYSSHNQPST
GGRTTITTKKYRTQYPILGLLYDDYEYIPPGSETQTIVIEKTEDKYTCP
Target Bioclass
Other
Subcellular location
Cell junction, tight junction
Function Plays a key role in the organization of epithelial monolayers by regulating the actin cytoskeleton. May be involved in ovary development.
Uniprot ID
Q8WVV4
Ensemble ID
ENST00000262753.9
HGNC ID
HGNC:13711

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C496(1.68)  LDD3314  [1]
Curcusone 37
 Probe Info  		2.17  LDD0188  [2]
Acrolein
 Probe Info  		N.A.  LDD0232  [3]
IA-alkyne
 Probe Info  		C425(0.00); C274(0.00)  LDD0162  [4]
NAIA_5
 Probe Info  		C398(0.00); C106(0.00); C274(0.00); C425(0.00)  LDD2223  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0632  CL-Sc Hep-G2 C106(1.82); C444(1.75); C274(0.92); C425(0.79)  LDD2227  [5]
 LDCM0033  Curcusone1d MCF-7 2.17  LDD0188  [2]
 LDCM0022  KB02 769-P C496(2.57)  LDD2246  [1]
 LDCM0023  KB03 769-P C496(2.60)  LDD2663  [1]
 LDCM0024  KB05 IGR37 C496(1.68)  LDD3314  [1]
 LDCM0109  NEM HeLa N.A.  LDD0232  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ADP-ribosylation factor-like protein 4A (ARL4A) Arf family P40617
GTP-binding protein GEM (GEM) RGK family P55040
Ret finger protein-like 3 (RFPL3) . O75679
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
B-cell lymphoma 6 protein (BCL6) . P41182
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein FAM90A1 (FAM90A1) FAM90 family Q86YD7
Periplakin (PPL) Plakin or cytolinker family O60437
Synaptotagmin-17 (SYT17) Synaptotagmin family Q9BSW7
BTB/POZ domain-containing protein KCTD9 (KCTD9) . Q7L273
Collagen alpha-1(VIII) chain (COL8A1) . P27658
Fibroblast growth factor receptor substrate 3 (FRS3) . O43559
Kelch-like protein 38 (KLHL38) . Q2WGJ6
Placental protein 13-like (LGALS14) . Q8TCE9

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Total Synthesis and Target Identification of the Curcusone Diterpenes. J Am Chem Soc. 2021 Mar 24;143(11):4379-4386. doi: 10.1021/jacs.1c00557. Epub 2021 Mar 11.
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264