Details of the Target

General Information of Target

Target ID LDTP08855
Target Name D-2-hydroxyglutarate dehydrogenase, mitochondrial (D2HGDH)
Gene Name D2HGDH
Gene ID 728294
Synonyms
D2HGD; D-2-hydroxyglutarate dehydrogenase, mitochondrial; EC 1.1.99.39
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MLPRRPLAWPAWLLRGAPGAAGSWGRPVGPLARRGCCSAPGTPEVPLTRERYPVRRLPFS
TVSKQDLAAFERIVPGGVVTDPEALQAPNVDWLRTLRGCSKVLLRPRTSEEVSHILRHCH
ERNLAVNPQGGNTGMVGGSVPVFDEIILSTARMNRVLSFHSVSGILVCQAGCVLEELSRY
VEERDFIMPLDLGAKGSCHIGGNVATNAGGLRFLRYGSLHGTVLGLEVVLADGTVLDCLT
SLRKDNTGYDLKQLFIGSEGTLGIITTVSILCPPKPRAVNVAFLGCPGFAEVLQTFSTCK
GMLGEILSAFEFMDAVCMQLVGRHLHLASPVQESPFYVLIETSGSNAGHDAEKLGHFLEH
ALGSGLVTDGTMATDQRKVKMLWALRERITEALSRDGYVYKYDLSLPVERLYDIVTDLRA
RLGPHAKHVVGYGHLGDGNLHLNVTAEAFSPSLLAALEPHVYEWTAGQQGSVSAEHGVGF
RKRDVLGYSKPPGALQLMQQLKALLDPKGILNPYKTLPSQA
Target Bioclass
Enzyme
Family
FAD-binding oxidoreductase/transferase type 4 family
Subcellular location
Mitochondrion
Function
Catalyzes the oxidation of D-2-hydroxyglutarate (D-2-HG) to alpha-ketoglutarate. Also catalyzes the oxidation of other D-2-hydroxyacids, such as D-malate (D-MAL) and D-lactate (D-LAC). Exhibits high activities towards D-2-HG and D-MAL but a very weak activity towards D-LAC.
Uniprot ID
Q8N465
Ensemble ID
ENST00000321264.9
HGNC ID
HGNC:28358

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CHL1 SNV: p.P141L .
JEKO1 SNV: p.S343L .
KELLY SNV: p.R4S .
KYSE30 SNV: p.F70V .
KYSE510 SNV: p.H220N .
LNCaP clone FGC SNV: p.A205S .
SNU1 SNV: p.V228A .
SNU1196 SNV: p.V102L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
Curcusone 37
 Probe Info  		2.62  LDD0188  [2]
DBIA
 Probe Info  		C286(1.26); C299(1.26)  LDD1095  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [4]
IPM
 Probe Info  		N.A.  LDD2156  [5]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [6]
NAIA_5
 Probe Info  		N.A.  LDD2223  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C198(1.07)  LDD1508  [8]
 LDCM0216  AC100 PaTu 8988t C286(1.26); C299(1.26)  LDD1095  [3]
 LDCM0217  AC101 PaTu 8988t C286(1.21); C299(1.21)  LDD1096  [3]
 LDCM0218  AC102 PaTu 8988t C286(1.07); C299(1.07)  LDD1097  [3]
 LDCM0219  AC103 PaTu 8988t C286(1.18); C299(1.18)  LDD1098  [3]
 LDCM0220  AC104 PaTu 8988t C286(1.20); C299(1.20)  LDD1099  [3]
 LDCM0221  AC105 PaTu 8988t C286(1.25); C299(1.25)  LDD1100  [3]
 LDCM0222  AC106 PaTu 8988t C286(1.09); C299(1.09)  LDD1101  [3]
 LDCM0223  AC107 PaTu 8988t C286(1.22); C299(1.22)  LDD1102  [3]
 LDCM0224  AC108 PaTu 8988t C286(1.17); C299(1.17)  LDD1103  [3]
 LDCM0225  AC109 PaTu 8988t C286(1.10); C299(1.10)  LDD1104  [3]
 LDCM0226  AC11 HEK-293T C299(0.93)  LDD1509  [8]
 LDCM0227  AC110 PaTu 8988t C286(2.05); C299(2.05)  LDD1106  [3]
 LDCM0228  AC111 PaTu 8988t C286(1.09); C299(1.09)  LDD1107  [3]
 LDCM0229  AC112 PaTu 8988t C286(1.47); C299(1.47)  LDD1108  [3]
 LDCM0230  AC113 PaTu 8988t C286(0.83); C299(0.83)  LDD1109  [3]
 LDCM0231  AC114 PaTu 8988t C286(0.85); C299(0.85)  LDD1110  [3]
 LDCM0232  AC115 PaTu 8988t C286(0.88); C299(0.88)  LDD1111  [3]
 LDCM0233  AC116 PaTu 8988t C286(0.77); C299(0.77)  LDD1112  [3]
 LDCM0234  AC117 PaTu 8988t C286(0.78); C299(0.78)  LDD1113  [3]
 LDCM0235  AC118 PaTu 8988t C286(1.16); C299(1.16)  LDD1114  [3]
 LDCM0236  AC119 PaTu 8988t C286(0.98); C299(0.98)  LDD1115  [3]
 LDCM0237  AC12 HEK-293T C198(1.03)  LDD1510  [8]
 LDCM0238  AC120 PaTu 8988t C286(0.98); C299(0.98)  LDD1117  [3]
 LDCM0239  AC121 PaTu 8988t C286(0.74); C299(0.74)  LDD1118  [3]
 LDCM0240  AC122 PaTu 8988t C286(1.14); C299(1.14)  LDD1119  [3]
 LDCM0241  AC123 PaTu 8988t C286(1.27); C299(1.27)  LDD1120  [3]
 LDCM0242  AC124 PaTu 8988t C286(1.89); C299(1.89)  LDD1121  [3]
 LDCM0243  AC125 PaTu 8988t C286(1.46); C299(1.46)  LDD1122  [3]
 LDCM0244  AC126 PaTu 8988t C286(1.23); C299(1.23)  LDD1123  [3]
 LDCM0245  AC127 PaTu 8988t C286(1.00); C299(1.00)  LDD1124  [3]
 LDCM0259  AC14 HEK-293T C198(0.96)  LDD1512  [8]
 LDCM0263  AC143 PaTu 8988t C286(1.25); C299(1.12)  LDD1142  [3]
 LDCM0264  AC144 PaTu 8988t C286(1.32); C299(1.13)  LDD1143  [3]
 LDCM0265  AC145 PaTu 8988t C286(1.07); C299(1.03)  LDD1144  [3]
 LDCM0266  AC146 PaTu 8988t C286(2.39); C299(3.16)  LDD1145  [3]
 LDCM0267  AC147 PaTu 8988t C286(1.18); C299(1.13)  LDD1146  [3]
 LDCM0268  AC148 PaTu 8988t C286(1.75); C299(1.28)  LDD1147  [3]
 LDCM0269  AC149 PaTu 8988t C286(1.72); C299(1.23)  LDD1148  [3]
 LDCM0270  AC15 HEK-293T C198(1.19)  LDD1513  [8]
 LDCM0271  AC150 PaTu 8988t C286(1.11); C299(0.85)  LDD1150  [3]
 LDCM0272  AC151 PaTu 8988t C286(1.65); C299(1.32)  LDD1151  [3]
 LDCM0273  AC152 PaTu 8988t C286(1.56); C299(1.02)  LDD1152  [3]
 LDCM0274  AC153 PaTu 8988t C286(1.34); C299(1.06)  LDD1153  [3]
 LDCM0621  AC154 PaTu 8988t C286(1.59); C299(1.04)  LDD2166  [3]
 LDCM0622  AC155 PaTu 8988t C286(1.40); C299(1.07)  LDD2167  [3]
 LDCM0623  AC156 PaTu 8988t C286(1.68); C299(1.21)  LDD2168  [3]
 LDCM0624  AC157 PaTu 8988t C286(1.61); C299(1.23)  LDD2169  [3]
 LDCM0277  AC18 HEK-293T C198(1.00)  LDD1516  [8]
 LDCM0278  AC19 HEK-293T C299(0.74)  LDD1517  [8]
 LDCM0279  AC2 HEK-293T C198(1.06)  LDD1518  [8]
 LDCM0280  AC20 HEK-293T C198(0.98)  LDD1519  [8]
 LDCM0282  AC22 HEK-293T C198(1.10)  LDD1521  [8]
 LDCM0283  AC23 HEK-293T C198(1.04)  LDD1522  [8]
 LDCM0284  AC24 HEK-293T C198(0.98)  LDD1523  [8]
 LDCM0285  AC25 PaTu 8988t C286(1.09); C299(1.09)  LDD1164  [3]
 LDCM0286  AC26 PaTu 8988t C286(0.91); C299(0.91)  LDD1165  [3]
 LDCM0287  AC27 PaTu 8988t C286(0.92); C299(0.92)  LDD1166  [3]
 LDCM0288  AC28 PaTu 8988t C286(1.15); C299(1.15)  LDD1167  [3]
 LDCM0289  AC29 PaTu 8988t C286(0.95); C299(0.95)  LDD1168  [3]
 LDCM0290  AC3 HEK-293T C299(1.04)  LDD1529  [8]
 LDCM0291  AC30 PaTu 8988t C286(0.97); C299(0.97)  LDD1170  [3]
 LDCM0292  AC31 PaTu 8988t C286(0.96); C299(0.96)  LDD1171  [3]
 LDCM0293  AC32 PaTu 8988t C286(1.05); C299(1.05)  LDD1172  [3]
 LDCM0294  AC33 PaTu 8988t C286(1.10); C299(1.10)  LDD1173  [3]
 LDCM0295  AC34 PaTu 8988t C286(1.05); C299(1.05)  LDD1174  [3]
 LDCM0296  AC35 HEK-293T C299(0.71)  LDD1535  [8]
 LDCM0297  AC36 HEK-293T C198(1.22)  LDD1536  [8]
 LDCM0299  AC38 HEK-293T C198(1.05)  LDD1538  [8]
 LDCM0300  AC39 HEK-293T C198(1.15)  LDD1539  [8]
 LDCM0301  AC4 HEK-293T C198(1.15)  LDD1540  [8]
 LDCM0302  AC40 HEK-293T C198(0.99)  LDD1541  [8]
 LDCM0304  AC42 HEK-293T C198(1.08)  LDD1543  [8]
 LDCM0305  AC43 HEK-293T C299(1.01)  LDD1544  [8]
 LDCM0306  AC44 HEK-293T C198(1.07)  LDD1545  [8]
 LDCM0308  AC46 PaTu 8988t C286(1.13); C299(1.13)  LDD1187  [3]
 LDCM0309  AC47 PaTu 8988t C286(1.05); C299(1.05)  LDD1188  [3]
 LDCM0310  AC48 PaTu 8988t C286(1.10); C299(1.10)  LDD1189  [3]
 LDCM0311  AC49 PaTu 8988t C286(1.19); C299(1.19)  LDD1190  [3]
 LDCM0313  AC50 PaTu 8988t C286(1.28); C299(1.28)  LDD1192  [3]
 LDCM0314  AC51 PaTu 8988t C286(2.06); C299(2.06)  LDD1193  [3]
 LDCM0315  AC52 PaTu 8988t C286(1.28); C299(1.28)  LDD1194  [3]
 LDCM0316  AC53 PaTu 8988t C286(1.41); C299(1.41)  LDD1195  [3]
 LDCM0317  AC54 PaTu 8988t C286(1.53); C299(1.53)  LDD1196  [3]
 LDCM0318  AC55 PaTu 8988t C286(1.14); C299(1.14)  LDD1197  [3]
 LDCM0319  AC56 PaTu 8988t C286(1.44); C299(1.44)  LDD1198  [3]
 LDCM0320  AC57 PaTu 8988t C286(1.18); C299(1.16)  LDD1199  [3]
 LDCM0321  AC58 PaTu 8988t C286(0.99); C299(1.02)  LDD1200  [3]
 LDCM0322  AC59 PaTu 8988t C286(1.17); C299(1.23)  LDD1201  [3]
 LDCM0323  AC6 HEK-293T C198(0.91)  LDD1562  [8]
 LDCM0324  AC60 PaTu 8988t C286(1.31); C299(1.27)  LDD1203  [3]
 LDCM0325  AC61 PaTu 8988t C286(1.03); C299(1.10)  LDD1204  [3]
 LDCM0326  AC62 PaTu 8988t C286(1.16); C299(1.20)  LDD1205  [3]
 LDCM0327  AC63 PaTu 8988t C286(1.15); C299(1.13)  LDD1206  [3]
 LDCM0328  AC64 PaTu 8988t C286(1.17); C299(1.04)  LDD1207  [3]
 LDCM0329  AC65 PaTu 8988t C286(1.08); C299(1.17)  LDD1208  [3]
 LDCM0330  AC66 PaTu 8988t C286(1.05); C299(1.06)  LDD1209  [3]
 LDCM0331  AC67 PaTu 8988t C286(1.13); C299(1.09)  LDD1210  [3]
 LDCM0332  AC68 PaTu 8988t C286(0.93); C299(0.93)  LDD1211  [3]
 LDCM0333  AC69 PaTu 8988t C286(0.91); C299(0.91)  LDD1212  [3]
 LDCM0334  AC7 HEK-293T C198(0.91)  LDD1568  [8]
 LDCM0335  AC70 PaTu 8988t C286(0.85); C299(0.85)  LDD1214  [3]
 LDCM0336  AC71 PaTu 8988t C286(0.97); C299(0.97)  LDD1215  [3]
 LDCM0337  AC72 PaTu 8988t C286(0.94); C299(0.94)  LDD1216  [3]
 LDCM0338  AC73 PaTu 8988t C286(0.93); C299(0.93)  LDD1217  [3]
 LDCM0339  AC74 PaTu 8988t C286(0.87); C299(0.87)  LDD1218  [3]
 LDCM0340  AC75 PaTu 8988t C286(0.86); C299(0.86)  LDD1219  [3]
 LDCM0341  AC76 PaTu 8988t C286(0.93); C299(0.93)  LDD1220  [3]
 LDCM0342  AC77 PaTu 8988t C286(0.83); C299(0.83)  LDD1221  [3]
 LDCM0343  AC78 PaTu 8988t C286(0.91); C299(0.91)  LDD1222  [3]
 LDCM0344  AC79 PaTu 8988t C286(0.84); C299(0.84)  LDD1223  [3]
 LDCM0345  AC8 HEK-293T C198(1.03)  LDD1569  [8]
 LDCM0346  AC80 PaTu 8988t C286(0.77); C299(0.77)  LDD1225  [3]
 LDCM0347  AC81 PaTu 8988t C286(0.95); C299(0.95)  LDD1226  [3]
 LDCM0348  AC82 PaTu 8988t C286(0.92); C299(0.92)  LDD1227  [3]
 LDCM0365  AC98 PaTu 8988t C286(1.35); C299(1.35)  LDD1244  [3]
 LDCM0366  AC99 PaTu 8988t C286(1.11); C299(1.11)  LDD1245  [3]
 LDCM0275  AKOS034007705 HEK-293T C198(1.00)  LDD1514  [8]
 LDCM0156  Aniline NCI-H1299 12.02  LDD0403  [1]
 LDCM0367  CL1 HEK-293T C198(1.00); C286(0.94)  LDD1571  [8]
 LDCM0368  CL10 HEK-293T C198(1.40)  LDD1572  [8]
 LDCM0369  CL100 HEK-293T C198(1.01)  LDD1573  [8]
 LDCM0370  CL101 HEK-293T C198(0.99); C286(0.91)  LDD1574  [8]
 LDCM0371  CL102 HEK-293T C198(0.80)  LDD1575  [8]
 LDCM0372  CL103 HEK-293T C198(1.05)  LDD1576  [8]
 LDCM0373  CL104 HEK-293T C198(1.08)  LDD1577  [8]
 LDCM0374  CL105 HEK-293T C198(0.96); C286(0.98)  LDD1578  [8]
 LDCM0375  CL106 HEK-293T C198(0.82)  LDD1579  [8]
 LDCM0376  CL107 HEK-293T C198(1.00)  LDD1580  [8]
 LDCM0377  CL108 HEK-293T C198(1.10)  LDD1581  [8]
 LDCM0378  CL109 HEK-293T C198(0.98); C286(0.90)  LDD1582  [8]
 LDCM0379  CL11 HEK-293T C198(1.11)  LDD1583  [8]
 LDCM0380  CL110 HEK-293T C198(0.80)  LDD1584  [8]
 LDCM0381  CL111 HEK-293T C198(1.17)  LDD1585  [8]
 LDCM0382  CL112 PaTu 8988t C286(1.07); C299(1.07)  LDD1261  [3]
 LDCM0383  CL113 PaTu 8988t C286(1.12); C299(1.12)  LDD1262  [3]
 LDCM0384  CL114 PaTu 8988t C286(1.62); C299(1.62)  LDD1263  [3]
 LDCM0385  CL115 PaTu 8988t C286(1.14); C299(1.14)  LDD1264  [3]
 LDCM0386  CL116 PaTu 8988t C286(0.99); C299(0.99)  LDD1265  [3]
 LDCM0387  CL117 HEK-293T C198(1.01); C286(0.94)  LDD1591  [8]
 LDCM0388  CL118 HEK-293T C198(0.94)  LDD1592  [8]
 LDCM0389  CL119 HEK-293T C198(1.11)  LDD1593  [8]
 LDCM0390  CL12 HEK-293T C198(0.93)  LDD1594  [8]
 LDCM0391  CL120 HEK-293T C198(1.40)  LDD1595  [8]
 LDCM0392  CL121 PaTu 8988t C286(1.37); C299(1.37)  LDD1271  [3]
 LDCM0393  CL122 PaTu 8988t C286(1.67); C299(1.67)  LDD1272  [3]
 LDCM0394  CL123 PaTu 8988t C286(3.45); C299(3.45)  LDD1273  [3]
 LDCM0395  CL124 PaTu 8988t C286(2.09); C299(2.09)  LDD1274  [3]
 LDCM0396  CL125 PaTu 8988t C286(1.15); C299(1.24)  LDD1275  [3]
 LDCM0397  CL126 PaTu 8988t C286(1.25); C299(1.57)  LDD1276  [3]
 LDCM0398  CL127 PaTu 8988t C286(1.36); C299(1.39)  LDD1277  [3]
 LDCM0399  CL128 PaTu 8988t C286(1.29); C299(1.25)  LDD1278  [3]
 LDCM0400  CL13 HEK-293T C198(0.97); C286(0.89)  LDD1604  [8]
 LDCM0401  CL14 HEK-293T C198(0.92)  LDD1605  [8]
 LDCM0402  CL15 HEK-293T C198(1.07)  LDD1606  [8]
 LDCM0403  CL16 HEK-293T C198(1.10)  LDD1607  [8]
 LDCM0405  CL18 HEK-293T C198(1.06)  LDD1609  [8]
 LDCM0406  CL19 HEK-293T C299(0.89)  LDD1610  [8]
 LDCM0407  CL2 HEK-293T C198(0.84)  LDD1611  [8]
 LDCM0408  CL20 HEK-293T C198(0.98)  LDD1612  [8]
 LDCM0410  CL22 HEK-293T C198(1.15)  LDD1614  [8]
 LDCM0411  CL23 HEK-293T C198(1.13)  LDD1615  [8]
 LDCM0412  CL24 HEK-293T C198(1.05)  LDD1616  [8]
 LDCM0413  CL25 HEK-293T C198(0.92); C286(0.93)  LDD1617  [8]
 LDCM0414  CL26 HEK-293T C198(0.86)  LDD1618  [8]
 LDCM0415  CL27 HEK-293T C198(1.06)  LDD1619  [8]
 LDCM0416  CL28 HEK-293T C198(1.05)  LDD1620  [8]
 LDCM0418  CL3 HEK-293T C198(1.07)  LDD1622  [8]
 LDCM0419  CL30 HEK-293T C198(1.15)  LDD1623  [8]
 LDCM0420  CL31 PaTu 8988t C286(1.44); C299(1.44)  LDD1299  [3]
 LDCM0421  CL32 PaTu 8988t C286(1.44); C299(1.44)  LDD1300  [3]
 LDCM0422  CL33 PaTu 8988t C286(1.39); C299(1.39)  LDD1301  [3]
 LDCM0423  CL34 PaTu 8988t C286(1.70); C299(1.70)  LDD1302  [3]
 LDCM0424  CL35 PaTu 8988t C286(1.51); C299(1.51)  LDD1303  [3]
 LDCM0425  CL36 PaTu 8988t C286(0.59); C299(0.59)  LDD1304  [3]
 LDCM0426  CL37 PaTu 8988t C286(1.85); C299(1.85)  LDD1305  [3]
 LDCM0428  CL39 PaTu 8988t C286(1.45); C299(1.45)  LDD1307  [3]
 LDCM0429  CL4 HEK-293T C198(1.10)  LDD1633  [8]
 LDCM0430  CL40 PaTu 8988t C286(1.35); C299(1.35)  LDD1309  [3]
 LDCM0431  CL41 PaTu 8988t C286(1.65); C299(1.65)  LDD1310  [3]
 LDCM0432  CL42 PaTu 8988t C286(1.44); C299(1.44)  LDD1311  [3]
 LDCM0433  CL43 PaTu 8988t C286(1.60); C299(1.60)  LDD1312  [3]
 LDCM0434  CL44 PaTu 8988t C286(1.65); C299(1.65)  LDD1313  [3]
 LDCM0435  CL45 PaTu 8988t C286(1.75); C299(1.75)  LDD1314  [3]
 LDCM0436  CL46 HEK-293T C198(1.10)  LDD1640  [8]
 LDCM0437  CL47 HEK-293T C198(0.97)  LDD1641  [8]
 LDCM0438  CL48 HEK-293T C198(1.04)  LDD1642  [8]
 LDCM0439  CL49 HEK-293T C198(1.01); C286(1.09)  LDD1643  [8]
 LDCM0441  CL50 HEK-293T C198(0.76)  LDD1645  [8]
 LDCM0443  CL52 HEK-293T C198(1.22)  LDD1646  [8]
 LDCM0445  CL54 HEK-293T C198(1.06)  LDD1648  [8]
 LDCM0446  CL55 HEK-293T C299(0.84)  LDD1649  [8]
 LDCM0447  CL56 HEK-293T C198(1.05)  LDD1650  [8]
 LDCM0449  CL58 HEK-293T C198(1.04)  LDD1652  [8]
 LDCM0450  CL59 HEK-293T C198(1.04)  LDD1653  [8]
 LDCM0451  CL6 HEK-293T C198(1.19)  LDD1654  [8]
 LDCM0452  CL60 HEK-293T C198(1.08)  LDD1655  [8]
 LDCM0453  CL61 PaTu 8988t C286(1.06); C299(1.06)  LDD1332  [3]
 LDCM0454  CL62 PaTu 8988t C286(1.17); C299(1.17)  LDD1333  [3]
 LDCM0455  CL63 PaTu 8988t C286(1.10); C299(1.10)  LDD1334  [3]
 LDCM0456  CL64 PaTu 8988t C286(2.73); C299(2.73)  LDD1335  [3]
 LDCM0457  CL65 PaTu 8988t C286(1.08); C299(1.08)  LDD1336  [3]
 LDCM0458  CL66 PaTu 8988t C286(1.80); C299(1.80)  LDD1337  [3]
 LDCM0459  CL67 PaTu 8988t C286(1.51); C299(1.51)  LDD1338  [3]
 LDCM0460  CL68 PaTu 8988t C286(1.71); C299(1.71)  LDD1339  [3]
 LDCM0461  CL69 PaTu 8988t C286(1.81); C299(1.81)  LDD1340  [3]
 LDCM0462  CL7 HEK-293T C299(1.22)  LDD1665  [8]
 LDCM0463  CL70 PaTu 8988t C286(0.96); C299(0.96)  LDD1342  [3]
 LDCM0464  CL71 PaTu 8988t C286(1.17); C299(1.17)  LDD1343  [3]
 LDCM0465  CL72 PaTu 8988t C286(1.07); C299(1.07)  LDD1344  [3]
 LDCM0466  CL73 PaTu 8988t C286(1.78); C299(1.78)  LDD1345  [3]
 LDCM0467  CL74 PaTu 8988t C286(1.31); C299(1.31)  LDD1346  [3]
 LDCM0469  CL76 HEK-293T C198(1.11)  LDD1672  [8]
 LDCM0471  CL78 HEK-293T C198(1.06)  LDD1674  [8]
 LDCM0472  CL79 HEK-293T C299(0.84)  LDD1675  [8]
 LDCM0473  CL8 HEK-293T C198(1.16)  LDD1676  [8]
 LDCM0474  CL80 HEK-293T C198(0.89)  LDD1677  [8]
 LDCM0476  CL82 HEK-293T C198(1.16)  LDD1679  [8]
 LDCM0477  CL83 HEK-293T C198(1.18)  LDD1680  [8]
 LDCM0478  CL84 HEK-293T C198(1.03)  LDD1681  [8]
 LDCM0479  CL85 HEK-293T C198(0.84); C286(0.88)  LDD1682  [8]
 LDCM0480  CL86 HEK-293T C198(0.77)  LDD1683  [8]
 LDCM0481  CL87 HEK-293T C198(0.93)  LDD1684  [8]
 LDCM0482  CL88 HEK-293T C198(1.03)  LDD1685  [8]
 LDCM0485  CL90 HEK-293T C198(1.28)  LDD1688  [8]
 LDCM0486  CL91 HEK-293T C299(0.92)  LDD1689  [8]
 LDCM0487  CL92 HEK-293T C198(1.05)  LDD1690  [8]
 LDCM0489  CL94 HEK-293T C198(1.03)  LDD1692  [8]
 LDCM0490  CL95 HEK-293T C198(1.24)  LDD1693  [8]
 LDCM0491  CL96 HEK-293T C198(0.89)  LDD1694  [8]
 LDCM0492  CL97 HEK-293T C198(0.95); C286(0.93)  LDD1695  [8]
 LDCM0493  CL98 HEK-293T C198(0.79)  LDD1696  [8]
 LDCM0494  CL99 HEK-293T C198(1.07)  LDD1697  [8]
 LDCM0033  Curcusone1d MCF-7 2.62  LDD0188  [2]
 LDCM0495  E2913 HEK-293T C198(1.10)  LDD1698  [8]
 LDCM0468  Fragment33 PaTu 8988t C286(1.55); C299(1.55)  LDD1347  [3]
 LDCM0427  Fragment51 PaTu 8988t C286(1.71); C299(1.71)  LDD1306  [3]
 LDCM0022  KB02 HEK-293T C198(0.95)  LDD1492  [8]
 LDCM0023  KB03 HEK-293T C198(1.02)  LDD1497  [8]
 LDCM0024  KB05 HEK-293T C198(1.03)  LDD1502  [8]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Total Synthesis and Target Identification of the Curcusone Diterpenes. J Am Chem Soc. 2021 Mar 24;143(11):4379-4386. doi: 10.1021/jacs.1c00557. Epub 2021 Mar 11.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
6 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402