Details of the Target

General Information of Target

Target ID LDTP16008
Target Name Transmembrane protein 134 (TMEM134)
Gene Name TMEM134
Gene ID 80194
Synonyms
Transmembrane protein 134
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDSELKEEIPVHEEFILCGGAETQVLKCGPWTDLFHDQSVKRPKLLIFIIPGNPGFSAFY
VPFAKALYSLTNRRFPVWTISHAGHALAPKDKKILTTSEDSNAQEIKDIYGLNGQIEHKL
AFLRTHVPKDMKLVLIGHSIGSYFTLQMLKRVPELPVIRAFLLFPTIERMSESPNGRIAT
PLLCWFRYVLYVTGYLLLKPCPETIKSLLIRRGLQVMNLENEFSPLNILEPFCLANAAYL
GGQEMMEVVKRDDETIKEHLCKLTFYYGTIDPWCPKEYYEDIKKDFPEGDIRLCEKNIPH
AFITHFNQEMADMIADSLKDDLSKM
Target Bioclass
Transporter and channel
Family
TMEM134/TMEM230 family
Subcellular location
Membrane
Uniprot ID
Q9H6X4
Ensemble ID
ENST00000308022.7
HGNC ID
HGNC:26142

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
TE10 SNV: p.A4V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C-Sul
 Probe Info  		11.80  LDD0066  [1]
Curcusone 37
 Probe Info  		2.50  LDD0188  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0033  Curcusone1d MCF-7 2.50  LDD0188  [2]

References

1 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
2 Total Synthesis and Target Identification of the Curcusone Diterpenes. J Am Chem Soc. 2021 Mar 24;143(11):4379-4386. doi: 10.1021/jacs.1c00557. Epub 2021 Mar 11.