Details of the Target

General Information of Target

Target ID LDTP01202
Target Name Serine/threonine-protein kinase ULK1 (ULK1)
Gene Name ULK1
Gene ID 8408
Synonyms
KIAA0722; Serine/threonine-protein kinase ULK1; EC 2.7.11.1; Autophagy-related protein 1 homolog; ATG1; hATG1; Unc-51-like kinase 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEPGRGGTETVGKFEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLL
GKEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQ
QIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAAT
LCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLV
PTIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFLDASPSVRKSPPVPVPSYPSSGS
GSSSSSSSTSHLASPPSLGEMQQLQKTLASPADTAGFLHSSRDSGGSKDSSCDTDDFVMV
PAQFPGDLVAEAPSAKPPPDSLMCSGSSLVASAGLESHGRTPSPSPPCSSSPSPSGRAGP
FSSSRCGASVPIPVPTQVQNYQRIERNLQSPTQFQTPRSSAIRRSGSTSPLGFARASPSP
PAHAEHGGVLARKMSLGGGRPYTPSPQVGTIPERPGWSGTPSPQGAEMRGGRSPRPGSSA
PEHSPRTSGLGCRLHSAPNLSDLHVVRPKLPKPPTDPLGAVFSPPQASPPQPSHGLQSCR
NLRGSPKLPDFLQRNPLPPILGSPTKAVPSFDFPKTPSSQNLLALLARQGVVMTPPRNRT
LPDLSEVGPFHGQPLGPGLRPGEDPKGPFGRSFSTSRLTDLLLKAAFGTQAPDPGSTESL
QEKPMEIAPSAGFGGSLHPGARAGGTSSPSPVVFTVGSPPSGSTPPQGPRTRMFSAGPTG
SASSSARHLVPGPCSEAPAPELPAPGHGCSFADPITANLEGAVTFEAPDLPEETLMEQEH
TEILRGLRFTLLFVQHVLEIAALKGSASEAAGGPEYQLQESVVADQISLLSREWGFAEQL
VLYLKVAELLSSGLQSAIDQIRAGKLCLSSTVKQVVRRLNELYKASVVSCQGLSLRLQRF
FLDKQRLLDRIHSITAERLIFSHAVQMVQSAALDEMFQHREGCVPRYHKALLLLEGLQHM
LSDQADIENVTKCKLCIERRLSALLTGICA
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
Protein kinase superfamily, Ser/Thr protein kinase family, APG1/unc-51/ULK1 subfamily
Subcellular location
Cytoplasm, cytosol
Function
Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation. Also phosphorylates SESN2 and SQSTM1 to regulate autophagy. Phosphorylates FLCN, promoting autophagy. Phosphorylates AMBRA1 in response to autophagy induction, releasing AMBRA1 from the cytoskeletal docking site to induce autophagosome nucleation. Phosphorylates ATG4B, leading to inhibit autophagy by decreasing both proteolytic activation and delipidation activities of ATG4B.
TTD ID
T79307
Uniprot ID
O75385
DrugMap ID
TT4D7MJ
Ensemble ID
ENST00000321867.6
HGNC ID
HGNC:12558
ChEMBL ID
CHEMBL6006

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Curcusone 37
 Probe Info  		2.98  LDD0188  [1]
DBIA
 Probe Info  		C552(4.21)  LDD0080  [2]
ATP probe
 Probe Info  		N.A.  LDD0199  [3]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [4]
NAIA_5
 Probe Info  		N.A.  LDD2224  [5]
IPM
 Probe Info  		N.A.  LDD0147  [6]
TFBX
 Probe Info  		N.A.  LDD0148  [6]
W1
 Probe Info  		N.A.  LDD0236  [7]
AOyne
 Probe Info  		13.80  LDD0443  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C1049(0.96)  LDD1093  [2]
 LDCM0215  AC10 HEK-293T C927(1.04); C426(1.10); C1049(0.84); C552(1.26)  LDD1508  [9]
 LDCM0226  AC11 HEK-293T C927(1.03); C426(1.03); C1049(0.78)  LDD1509  [9]
 LDCM0237  AC12 HEK-293T C927(1.02); C426(1.20); C1049(1.11)  LDD1510  [9]
 LDCM0259  AC14 HEK-293T C927(1.01); C426(1.10); C1049(0.64); C552(1.07)  LDD1512  [9]
 LDCM0270  AC15 HEK-293T C927(1.10); C426(1.17); C1049(0.91)  LDD1513  [9]
 LDCM0276  AC17 HEK-293T C927(1.08); C426(0.94); C1049(0.77); C552(1.04)  LDD1515  [9]
 LDCM0277  AC18 HEK-293T C927(0.93); C426(0.97); C1049(0.92); C552(1.18)  LDD1516  [9]
 LDCM0278  AC19 HEK-293T C927(1.03); C426(1.28); C1049(1.09)  LDD1517  [9]
 LDCM0279  AC2 PaTu 8988t C1049(1.40)  LDD1158  [2]
 LDCM0280  AC20 HEK-293T C927(0.92); C426(1.14); C1049(0.95)  LDD1519  [9]
 LDCM0281  AC21 HEK-293T C927(0.92); C426(1.22); C1049(0.64); C552(1.07)  LDD1520  [9]
 LDCM0282  AC22 HEK-293T C927(0.93); C426(1.01); C1049(0.90); C552(1.02)  LDD1521  [9]
 LDCM0283  AC23 HEK-293T C927(1.02); C426(0.98); C1049(0.91)  LDD1522  [9]
 LDCM0284  AC24 HEK-293T C927(0.94); C426(0.88); C1049(0.97); C552(0.96)  LDD1523  [9]
 LDCM0285  AC25 PaTu 8988t C1049(0.68)  LDD1164  [2]
 LDCM0286  AC26 PaTu 8988t C1049(0.88)  LDD1165  [2]
 LDCM0287  AC27 PaTu 8988t C1049(1.22)  LDD1166  [2]
 LDCM0288  AC28 PaTu 8988t C1049(1.18)  LDD1167  [2]
 LDCM0289  AC29 PaTu 8988t C1049(0.72)  LDD1168  [2]
 LDCM0290  AC3 PaTu 8988t C1049(1.42)  LDD1169  [2]
 LDCM0291  AC30 PaTu 8988t C1049(0.67)  LDD1170  [2]
 LDCM0292  AC31 PaTu 8988t C1049(0.63)  LDD1171  [2]
 LDCM0293  AC32 PaTu 8988t C1049(0.70)  LDD1172  [2]
 LDCM0294  AC33 PaTu 8988t C1049(0.92)  LDD1173  [2]
 LDCM0295  AC34 PaTu 8988t C1049(0.82)  LDD1174  [2]
 LDCM0296  AC35 HEK-293T C927(1.04); C426(1.06); C1049(1.02)  LDD1535  [9]
 LDCM0297  AC36 HEK-293T C927(1.02); C426(1.28); C1049(0.78)  LDD1536  [9]
 LDCM0298  AC37 HEK-293T C927(1.05); C426(1.02); C1049(0.81); C552(1.04)  LDD1537  [9]
 LDCM0299  AC38 HEK-293T C927(1.16); C426(1.07); C1049(0.95); C552(1.03)  LDD1538  [9]
 LDCM0300  AC39 HEK-293T C927(1.07); C426(1.18); C1049(1.25)  LDD1539  [9]
 LDCM0301  AC4 PaTu 8988t C1049(0.96)  LDD1180  [2]
 LDCM0302  AC40 HEK-293T C927(1.02); C426(0.88); C1049(0.89); C552(1.04)  LDD1541  [9]
 LDCM0303  AC41 HEK-293T C927(1.12); C426(1.11); C1049(0.75); C552(1.15)  LDD1542  [9]
 LDCM0304  AC42 HEK-293T C927(1.03); C426(1.02); C1049(0.80); C552(1.21)  LDD1543  [9]
 LDCM0305  AC43 HEK-293T C927(1.01); C426(0.96); C1049(1.20)  LDD1544  [9]
 LDCM0306  AC44 HEK-293T C927(0.97); C426(1.18); C1049(1.03)  LDD1545  [9]
 LDCM0307  AC45 HEK-293T C927(0.96); C426(1.16); C1049(0.84); C552(1.12)  LDD1546  [9]
 LDCM0308  AC46 PaTu 8988t C1049(1.07)  LDD1187  [2]
 LDCM0309  AC47 PaTu 8988t C1049(1.23)  LDD1188  [2]
 LDCM0310  AC48 PaTu 8988t C1049(1.15)  LDD1189  [2]
 LDCM0311  AC49 PaTu 8988t C1049(1.05)  LDD1190  [2]
 LDCM0312  AC5 PaTu 8988t C1049(1.22)  LDD1191  [2]
 LDCM0313  AC50 PaTu 8988t C1049(1.23)  LDD1192  [2]
 LDCM0314  AC51 PaTu 8988t C1049(1.20)  LDD1193  [2]
 LDCM0315  AC52 PaTu 8988t C1049(1.28)  LDD1194  [2]
 LDCM0316  AC53 PaTu 8988t C1049(1.07)  LDD1195  [2]
 LDCM0317  AC54 PaTu 8988t C1049(1.72)  LDD1196  [2]
 LDCM0318  AC55 PaTu 8988t C1049(1.03)  LDD1197  [2]
 LDCM0319  AC56 PaTu 8988t C1049(1.25)  LDD1198  [2]
 LDCM0320  AC57 HEK-293T C927(1.12); C426(1.11); C1049(0.64); C552(1.15)  LDD1559  [9]
 LDCM0321  AC58 HEK-293T C927(1.06); C426(0.95); C1049(0.88); C552(1.22)  LDD1560  [9]
 LDCM0322  AC59 HEK-293T C927(0.94); C426(0.94); C1049(1.09)  LDD1561  [9]
 LDCM0323  AC6 HEK-293T C927(1.10); C426(1.01); C1049(0.63); C552(1.11)  LDD1562  [9]
 LDCM0324  AC60 HEK-293T C927(1.07); C426(1.05); C1049(1.07)  LDD1563  [9]
 LDCM0325  AC61 HEK-293T C927(0.88); C426(1.11); C1049(0.70); C552(1.09)  LDD1564  [9]
 LDCM0326  AC62 HEK-293T C927(1.10); C426(1.12); C1049(0.81); C552(1.10)  LDD1565  [9]
 LDCM0327  AC63 HEK-293T C927(1.15); C426(0.92); C1049(1.19)  LDD1566  [9]
 LDCM0328  AC64 HEK-293T C927(0.98); C426(0.82); C1049(0.94); C552(0.98)  LDD1567  [9]
 LDCM0332  AC68 PaTu 8988t C1049(1.10)  LDD1211  [2]
 LDCM0333  AC69 PaTu 8988t C1049(0.98)  LDD1212  [2]
 LDCM0334  AC7 HEK-293T C927(0.98); C426(0.98); C1049(0.90)  LDD1568  [9]
 LDCM0335  AC70 PaTu 8988t C1049(0.90)  LDD1214  [2]
 LDCM0336  AC71 PaTu 8988t C1049(0.97)  LDD1215  [2]
 LDCM0337  AC72 PaTu 8988t C1049(0.85)  LDD1216  [2]
 LDCM0338  AC73 PaTu 8988t C1049(0.99)  LDD1217  [2]
 LDCM0339  AC74 PaTu 8988t C1049(1.05)  LDD1218  [2]
 LDCM0340  AC75 PaTu 8988t C1049(1.08)  LDD1219  [2]
 LDCM0341  AC76 PaTu 8988t C1049(0.97)  LDD1220  [2]
 LDCM0342  AC77 PaTu 8988t C1049(0.87)  LDD1221  [2]
 LDCM0343  AC78 PaTu 8988t C1049(0.83)  LDD1222  [2]
 LDCM0344  AC79 PaTu 8988t C1049(0.94)  LDD1223  [2]
 LDCM0345  AC8 HEK-293T C927(0.94); C426(0.95); C1049(0.98); C552(1.00)  LDD1569  [9]
 LDCM0346  AC80 PaTu 8988t C1049(0.86)  LDD1225  [2]
 LDCM0347  AC81 PaTu 8988t C1049(1.02)  LDD1226  [2]
 LDCM0348  AC82 PaTu 8988t C1049(0.81)  LDD1227  [2]
 LDCM0248  AKOS034007472 HEK-293T C927(0.99); C426(1.00); C1049(0.78); C552(1.09)  LDD1511  [9]
 LDCM0356  AKOS034007680 HEK-293T C927(1.14); C426(1.13); C1049(0.79); C552(1.06)  LDD1570  [9]
 LDCM0275  AKOS034007705 HEK-293T C927(0.92); C426(1.00); C1049(1.15); C552(1.06)  LDD1514  [9]
 LDCM0367  CL1 HEK-293T C927(1.32); C426(0.95); C1049(0.71); C408(0.97)  LDD1571  [9]
 LDCM0368  CL10 HEK-293T C927(2.10); C426(1.03); C1049(0.54); C552(1.31)  LDD1572  [9]
 LDCM0369  CL100 PaTu 8988t C1049(1.03)  LDD1248  [2]
 LDCM0370  CL101 HEK-293T C927(1.17); C426(0.93); C1049(0.71); C408(0.86)  LDD1574  [9]
 LDCM0371  CL102 HEK-293T C927(1.16); C426(0.87); C1049(0.67); C408(0.96)  LDD1575  [9]
 LDCM0372  CL103 HEK-293T C927(1.02); C426(1.10); C1049(0.70); C950(1.05)  LDD1576  [9]
 LDCM0373  CL104 HEK-293T C927(0.95); C426(0.90); C1049(0.82); C408(1.10)  LDD1577  [9]
 LDCM0374  CL105 HEK-293T C927(0.88); C426(1.16); C1049(0.76); C408(0.96)  LDD1578  [9]
 LDCM0375  CL106 HEK-293T C927(1.14); C426(1.03); C1049(0.81); C408(0.72)  LDD1579  [9]
 LDCM0376  CL107 HEK-293T C927(0.95); C426(0.99); C1049(0.75); C950(0.98)  LDD1580  [9]
 LDCM0377  CL108 HEK-293T C927(1.00); C426(0.95); C1049(0.76); C408(0.79)  LDD1581  [9]
 LDCM0378  CL109 HEK-293T C927(0.92); C426(0.91); C1049(0.84); C408(0.90)  LDD1582  [9]
 LDCM0379  CL11 HEK-293T C927(1.29); C426(1.12); C1049(1.29)  LDD1583  [9]
 LDCM0380  CL110 HEK-293T C927(1.16); C426(0.95); C1049(0.79); C408(1.09)  LDD1584  [9]
 LDCM0381  CL111 HEK-293T C927(1.07); C426(1.00); C1049(0.76); C950(0.86)  LDD1585  [9]
 LDCM0382  CL112 PaTu 8988t C1049(0.82)  LDD1261  [2]
 LDCM0383  CL113 PaTu 8988t C1049(0.86)  LDD1262  [2]
 LDCM0384  CL114 PaTu 8988t C1049(0.86)  LDD1263  [2]
 LDCM0385  CL115 PaTu 8988t C1049(0.94)  LDD1264  [2]
 LDCM0386  CL116 PaTu 8988t C1049(1.01)  LDD1265  [2]
 LDCM0387  CL117 HEK-293T C927(1.14); C426(0.91); C1049(0.86); C408(1.09)  LDD1591  [9]
 LDCM0388  CL118 HEK-293T C927(1.05); C426(1.27); C1049(0.80); C408(0.81)  LDD1592  [9]
 LDCM0389  CL119 HEK-293T C927(0.98); C426(1.04); C1049(0.74); C950(0.93)  LDD1593  [9]
 LDCM0390  CL12 HEK-293T C927(1.23); C426(1.13); C1049(1.05); C552(0.90)  LDD1594  [9]
 LDCM0391  CL120 HEK-293T C927(0.99); C426(1.06); C1049(0.82); C408(0.86)  LDD1595  [9]
 LDCM0392  CL121 PaTu 8988t C1049(1.46)  LDD1271  [2]
 LDCM0393  CL122 PaTu 8988t C1049(0.95)  LDD1272  [2]
 LDCM0394  CL123 PaTu 8988t C1049(1.56)  LDD1273  [2]
 LDCM0395  CL124 PaTu 8988t C1049(1.22)  LDD1274  [2]
 LDCM0396  CL125 HEK-293T C927(0.93); C426(0.93); C1049(0.70); C408(0.85)  LDD1600  [9]
 LDCM0397  CL126 HEK-293T C927(1.17); C426(0.92); C1049(0.53); C408(1.10)  LDD1601  [9]
 LDCM0398  CL127 HEK-293T C927(1.02); C426(1.07); C1049(0.74); C950(1.11)  LDD1602  [9]
 LDCM0399  CL128 HEK-293T C927(1.05); C426(0.93); C1049(0.90); C408(0.86)  LDD1603  [9]
 LDCM0400  CL13 HEK-293T C927(1.13); C426(0.87); C1049(0.76); C408(0.97)  LDD1604  [9]
 LDCM0401  CL14 HEK-293T C927(1.18); C426(0.99); C1049(0.83); C408(0.92)  LDD1605  [9]
 LDCM0402  CL15 HEK-293T C927(1.20); C426(1.02); C1049(0.68); C950(0.94)  LDD1606  [9]
 LDCM0403  CL16 HEK-293T C927(0.95); C426(0.93); C1049(0.76); C408(1.18)  LDD1607  [9]
 LDCM0404  CL17 HEK-293T C927(1.44); C426(1.12); C1049(0.66); C552(1.19)  LDD1608  [9]
 LDCM0405  CL18 HEK-293T C927(1.08); C426(1.05); C1049(1.05); C552(1.21)  LDD1609  [9]
 LDCM0406  CL19 HEK-293T C927(1.05); C426(1.06); C1049(1.57)  LDD1610  [9]
 LDCM0407  CL2 HEK-293T C927(1.14); C426(1.02); C1049(0.80); C408(0.91)  LDD1611  [9]
 LDCM0408  CL20 HEK-293T C927(1.09); C426(1.16); C1049(0.71)  LDD1612  [9]
 LDCM0409  CL21 HEK-293T C927(1.70); C426(0.99); C1049(0.83); C552(1.14)  LDD1613  [9]
 LDCM0410  CL22 HEK-293T C927(1.39); C426(1.12); C1049(1.14); C552(1.13)  LDD1614  [9]
 LDCM0411  CL23 HEK-293T C927(1.31); C426(1.25); C1049(1.41)  LDD1615  [9]
 LDCM0412  CL24 HEK-293T C927(1.19); C426(1.23); C1049(1.01); C552(0.94)  LDD1616  [9]
 LDCM0413  CL25 HEK-293T C927(1.69); C426(0.84); C1049(0.65); C408(0.94)  LDD1617  [9]
 LDCM0414  CL26 HEK-293T C927(0.98); C426(1.11); C1049(0.80); C408(1.02)  LDD1618  [9]
 LDCM0415  CL27 HEK-293T C927(0.90); C426(1.01); C1049(0.62); C950(0.89)  LDD1619  [9]
 LDCM0416  CL28 HEK-293T C927(0.98); C426(1.01); C1049(0.70); C408(1.00)  LDD1620  [9]
 LDCM0417  CL29 HEK-293T C927(1.05); C426(0.98); C1049(0.70); C552(1.06)  LDD1621  [9]
 LDCM0418  CL3 HEK-293T C927(1.08); C426(0.88); C1049(0.61); C950(0.98)  LDD1622  [9]
 LDCM0419  CL30 HEK-293T C927(1.01); C426(1.01); C1049(0.92); C552(0.96)  LDD1623  [9]
 LDCM0420  CL31 HEK-293T C927(1.02); C426(0.92); C1049(0.72)  LDD1624  [9]
 LDCM0421  CL32 HEK-293T C927(1.07); C426(1.14); C1049(0.90)  LDD1625  [9]
 LDCM0422  CL33 HEK-293T C927(1.80); C426(1.08); C1049(0.72); C552(1.14)  LDD1626  [9]
 LDCM0423  CL34 HEK-293T C927(1.60); C426(1.12); C1049(0.84); C552(1.07)  LDD1627  [9]
 LDCM0424  CL35 HEK-293T C927(1.28); C426(1.00); C1049(0.85)  LDD1628  [9]
 LDCM0425  CL36 HEK-293T C927(1.26); C426(0.93); C1049(1.00); C552(0.92)  LDD1629  [9]
 LDCM0426  CL37 HEK-293T C927(0.90); C426(0.98); C1049(0.87); C408(0.94)  LDD1630  [9]
 LDCM0428  CL39 HEK-293T C927(1.03); C426(1.23); C1049(0.71); C950(0.94)  LDD1632  [9]
 LDCM0429  CL4 HEK-293T C927(1.11); C426(1.08); C1049(0.79); C408(0.96)  LDD1633  [9]
 LDCM0430  CL40 HEK-293T C927(0.99); C426(1.07); C1049(0.80); C408(1.02)  LDD1634  [9]
 LDCM0431  CL41 HEK-293T C927(1.18); C426(1.10); C1049(0.63); C552(1.02)  LDD1635  [9]
 LDCM0432  CL42 HEK-293T C927(1.02); C426(1.07); C1049(0.86); C552(1.20)  LDD1636  [9]
 LDCM0433  CL43 HEK-293T C927(1.00); C426(0.98); C1049(1.27)  LDD1637  [9]
 LDCM0434  CL44 HEK-293T C927(1.15); C426(1.21); C1049(0.95)  LDD1638  [9]
 LDCM0435  CL45 HEK-293T C927(1.32); C426(1.02); C1049(1.02); C552(1.14)  LDD1639  [9]
 LDCM0436  CL46 HEK-293T C927(1.16); C426(1.02); C1049(1.07); C552(1.05)  LDD1640  [9]
 LDCM0437  CL47 HEK-293T C927(1.24); C426(0.98); C1049(1.14)  LDD1641  [9]
 LDCM0438  CL48 HEK-293T C927(1.27); C426(1.18); C1049(1.15); C552(0.97)  LDD1642  [9]
 LDCM0439  CL49 HEK-293T C927(0.84); C426(0.95); C1049(0.82); C408(0.98)  LDD1643  [9]
 LDCM0440  CL5 HEK-293T C927(1.08); C426(1.13); C1049(0.73); C552(1.02)  LDD1644  [9]
 LDCM0441  CL50 HEK-293T C927(1.22); C426(1.01); C1049(0.81); C408(0.92)  LDD1645  [9]
 LDCM0443  CL52 HEK-293T C927(0.98); C426(0.92); C1049(0.85); C408(1.29)  LDD1646  [9]
 LDCM0444  CL53 HEK-293T C927(1.41); C426(1.06); C1049(0.63); C552(1.30)  LDD1647  [9]
 LDCM0445  CL54 HEK-293T C927(1.58); C426(1.01); C1049(0.69); C552(1.18)  LDD1648  [9]
 LDCM0446  CL55 HEK-293T C927(1.23); C426(0.94); C1049(0.88)  LDD1649  [9]
 LDCM0447  CL56 HEK-293T C927(1.23); C426(1.35); C1049(0.86)  LDD1650  [9]
 LDCM0448  CL57 HEK-293T C927(1.52); C426(1.10); C1049(0.98); C552(1.22)  LDD1651  [9]
 LDCM0449  CL58 HEK-293T C927(1.50); C426(1.31); C1049(0.75); C552(1.29)  LDD1652  [9]
 LDCM0450  CL59 HEK-293T C927(1.42); C426(1.06); C1049(1.18)  LDD1653  [9]
 LDCM0451  CL6 HEK-293T C927(1.23); C426(0.98); C1049(0.86); C552(1.12)  LDD1654  [9]
 LDCM0452  CL60 HEK-293T C927(1.08); C426(0.82); C1049(1.16); C552(0.99)  LDD1655  [9]
 LDCM0453  CL61 HEK-293T C927(0.91); C426(0.91); C1049(0.72); C408(1.11)  LDD1656  [9]
 LDCM0454  CL62 HEK-293T C927(0.98); C426(1.01); C1049(0.82); C408(0.73)  LDD1657  [9]
 LDCM0455  CL63 HEK-293T C927(1.05); C426(0.89); C1049(0.54); C950(0.94)  LDD1658  [9]
 LDCM0456  CL64 HEK-293T C927(1.10); C426(0.96); C1049(0.62); C408(0.83)  LDD1659  [9]
 LDCM0457  CL65 HEK-293T C927(1.19); C426(1.15); C1049(0.82); C552(1.17)  LDD1660  [9]
 LDCM0458  CL66 HEK-293T C927(1.09); C426(1.05); C1049(0.96); C552(1.15)  LDD1661  [9]
 LDCM0459  CL67 HEK-293T C927(1.04); C426(0.86); C1049(0.87)  LDD1662  [9]
 LDCM0460  CL68 HEK-293T C927(1.38); C426(0.99); C1049(0.74)  LDD1663  [9]
 LDCM0461  CL69 HEK-293T C927(1.41); C426(1.07); C1049(0.67); C552(1.11)  LDD1664  [9]
 LDCM0462  CL7 HEK-293T C927(1.30); C426(1.04); C1049(0.95)  LDD1665  [9]
 LDCM0463  CL70 HEK-293T C927(1.14); C426(1.08); C1049(0.96); C552(1.09)  LDD1666  [9]
 LDCM0464  CL71 HEK-293T C927(1.21); C426(1.09); C1049(1.14)  LDD1667  [9]
 LDCM0465  CL72 HEK-293T C927(1.12); C426(0.80); C1049(1.13); C552(1.04)  LDD1668  [9]
 LDCM0466  CL73 HEK-293T C927(0.93); C426(0.83); C1049(0.69); C408(0.86)  LDD1669  [9]
 LDCM0467  CL74 HEK-293T C927(1.03); C426(0.85); C1049(0.88); C408(0.70)  LDD1670  [9]
 LDCM0469  CL76 HEK-293T C927(0.99); C426(0.95); C1049(0.87); C408(0.91)  LDD1672  [9]
 LDCM0470  CL77 HEK-293T C927(1.28); C426(1.06); C1049(0.59); C552(1.17)  LDD1673  [9]
 LDCM0471  CL78 HEK-293T C927(1.06); C426(1.12); C1049(0.96); C552(1.14)  LDD1674  [9]
 LDCM0472  CL79 HEK-293T C927(1.12); C426(0.89); C1049(1.00)  LDD1675  [9]
 LDCM0473  CL8 HEK-293T C927(1.62); C426(1.14); C1049(0.58)  LDD1676  [9]
 LDCM0474  CL80 HEK-293T C927(1.05); C426(1.15); C1049(0.83)  LDD1677  [9]
 LDCM0475  CL81 HEK-293T C927(1.03); C426(1.12); C1049(0.86); C552(1.14)  LDD1678  [9]
 LDCM0476  CL82 HEK-293T C927(1.08); C426(0.99); C1049(0.83); C552(1.10)  LDD1679  [9]
 LDCM0477  CL83 HEK-293T C927(1.25); C426(1.09); C1049(1.08)  LDD1680  [9]
 LDCM0478  CL84 HEK-293T C927(1.14); C426(0.86); C1049(1.04); C552(1.05)  LDD1681  [9]
 LDCM0479  CL85 HEK-293T C927(0.91); C426(1.08); C1049(0.78); C408(0.78)  LDD1682  [9]
 LDCM0480  CL86 HEK-293T C927(0.99); C426(1.06); C1049(0.91); C408(0.87)  LDD1683  [9]
 LDCM0481  CL87 HEK-293T C927(1.09); C426(1.11); C1049(0.73); C950(1.08)  LDD1684  [9]
 LDCM0482  CL88 HEK-293T C927(1.03); C426(1.03); C1049(0.68); C408(1.48)  LDD1685  [9]
 LDCM0483  CL89 HEK-293T C927(1.19); C426(1.10); C1049(0.63); C552(1.11)  LDD1686  [9]
 LDCM0484  CL9 HEK-293T C927(1.40); C426(1.30); C1049(0.92); C552(1.10)  LDD1687  [9]
 LDCM0485  CL90 HEK-293T C927(1.36); C426(0.96); C1049(0.45); C552(1.43)  LDD1688  [9]
 LDCM0486  CL91 PaTu 8988t C1049(0.95)  LDD1365  [2]
 LDCM0487  CL92 PaTu 8988t C1049(0.97)  LDD1366  [2]
 LDCM0488  CL93 PaTu 8988t C1049(1.14)  LDD1367  [2]
 LDCM0489  CL94 PaTu 8988t C1049(1.11)  LDD1368  [2]
 LDCM0490  CL95 PaTu 8988t C1049(1.04)  LDD1369  [2]
 LDCM0491  CL96 PaTu 8988t C1049(0.76)  LDD1370  [2]
 LDCM0492  CL97 PaTu 8988t C1049(1.07)  LDD1371  [2]
 LDCM0493  CL98 PaTu 8988t C1049(1.18)  LDD1372  [2]
 LDCM0494  CL99 PaTu 8988t C1049(1.19)  LDD1373  [2]
 LDCM0033  Curcusone1d MCF-7 2.98  LDD0188  [1]
 LDCM0634  CY-0357 Hep-G2 C426(1.07)  LDD2228  [5]
 LDCM0495  E2913 HEK-293T C927(1.11); C426(0.82); C1049(0.69); C950(0.83)  LDD1698  [9]
 LDCM0468  Fragment33 HEK-293T C927(1.13); C426(1.03); C1049(0.68); C950(0.97)  LDD1671  [9]
 LDCM0427  Fragment51 HEK-293T C927(1.01); C426(0.99); C1049(0.84); C408(0.90)  LDD1631  [9]
 LDCM0022  KB02 HCT 116 C552(4.21)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C552(3.18)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C552(9.63)  LDD0082  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
5'-AMP-activated protein kinase subunit beta-1 (PRKAB1) 5'-AMP-activated protein kinase beta subunit family Q9Y478
Serine/threonine-protein kinase mTOR (MTOR) PI3/PI4-kinase family P42345
3-phosphoinositide-dependent protein kinase 1 (PDPK1) AGC Ser/Thr protein kinase family O15530
5'-AMP-activated protein kinase catalytic subunit alpha-2 (PRKAA2) CAMK Ser/Thr protein kinase family P54646
Serine/threonine-protein kinase ULK1 (ULK1) Ser/Thr protein kinase family O75385
High affinity nerve growth factor receptor (NTRK1) Tyr protein kinase family P04629
TNF receptor-associated factor 6 (TRAF6) TNF receptor-associated factor family Q9Y4K3
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Autophagy-related protein 13 (ATG13) ATG13 family O75143
Huntingtin (HTT) Huntingtin family P42858
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
RB1-inducible coiled-coil protein 1 (RB1CC1) ATG17 family Q8TDY2
Gamma-aminobutyric acid receptor-associated protein-like 1 (GABARAPL1) ATG8 family Q9H0R8
Gamma-aminobutyric acid receptor-associated protein-like 2 (GABARAPL2) ATG8 family P60520
Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) ATG8 family Q9GZQ8
Microtubule-associated proteins 1A/1B light chain 3C (MAP1LC3C) ATG8 family Q9BXW4
Activating molecule in BECN1-regulated autophagy protein 1 (AMBRA1) WD repeat AMBRA1 family Q9C0C7
Regulatory-associated protein of mTOR (RPTOR) WD repeat RAPTOR family Q8N122
TBC1 domain family member 14 (TBC1D14) . Q9P2M4

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Fostamatinib Small molecular drug DB12010
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pmid21967808cr-16 Small molecular drug D00EMH

References

1 Total Synthesis and Target Identification of the Curcusone Diterpenes. J Am Chem Soc. 2021 Mar 24;143(11):4379-4386. doi: 10.1021/jacs.1c00557. Epub 2021 Mar 11.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402