Details of the Target

General Information of Target

Target ID LDTP06184
Target Name Genetic suppressor element 1 (GSE1)
Gene Name GSE1
Gene ID 23199
Synonyms
KIAA0182; Genetic suppressor element 1
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MKGMSHEPKSPSLGMLSTATRTTATVNPLTPSPLNGALVPSGSPATSSALSAQAAPSSSF
AAALRKLAKQAEEPRGSSLSSESSPVSSPATNHSSPASTPKRVPMGPIIVPPGGHSVPST
PPVVTIAPTKTVNGVWRSESRQDAGSRSSSGGRERLIVEPPLPQEKAGGPAIPSHLLSTP
YPFGLSPSSVVQDSRFPPLNLQRPVHHVVPPSTVTEDYLRSFRPYHTTDDLRMSSLPPLG
LDPATAAAYYHPSYLAPHPFPHPAFRMDDSYCLSALRSPFYPIPTPGSLPPLHPSAMHLH
LSGVRYPPELSHSSLAALHSERMSGLSAERLQMDEELRREREREREREREREADREREKE
REREREKEREQEKEREREKERERELERQREQRAREKELLAAKALEPSFLPVAELHGLRGH
ATEERGKPSEQLTPTRAEKLKDAGLQAPKPVQHPLHPVPTPHHTVPSLISNHGIFSLPSS
SAATALLIQRTNEEEKWLARQRRLRQEKEDRQSQVSEFRQQVLEQHLDMGRPPVPAEAEH
RPESTTRPGPNRHEPGGRDPPQHFGGPPPLISPKPQLHAAPTALWNPVSLMDNTLETRRA
ESHSLHSHPAAFEPSRQAAVPLVKVERVFCPEKAEEGPRKREPAPLDKYQPPPPPPREGG
SLEHQPFLPGPGPFLAELEKSTQTILGQQRASLPQAATFGELSGPLKPGSPYRPPVPRAP
DPAYIYDEFLQQRRRLVSKLDLEERRRREAQEKGYYYDLDDSYDESDEEEVRAHLRCVAE
QPPLKLDTSSEKLEFLQLFGLTTQQQKEELVAQKRRKRRRMLRERSPSPPTIQSKRQTPS
PRLALSTRYSPDEMNNSPNFEEKKKFLTIFNLTHISAEKRKDKERLVEMLRAMKQKALSA
AVADSLTNSPRDSPAVSLSEPATQQASLDVEKPVGVAASLSDIPKAAEPGKLEQVRPQEL
SRVQELAPASGEKARLSEAPGGKKSLSMLHYIRGAAPKDIPVPLSHSTNGKSKPWEPFVA
EEFAHQFHESVLQSTQKALQKHKGSVAVLSAEQNHKVDTSVHYNIPELQSSSRAPPPQHN
GQQEPPTARKGPPTQELDRDSEEEEEEDDEDGEDEEEVPKRKWQGIEAVFEAYQEHIEEQ
NLERQVLQTQCRRLEARHYSLSLTAEQLSHSVAELRSQKQKMVSERERLQAELDHLRKCL
ALPAMHWPRGYLKGYPR
Target Bioclass
Other
Uniprot ID
Q14687
Ensemble ID
ENST00000253458.12
HGNC ID
HGNC:28979

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
BT549 SNV: p.A482P DBIA    Probe Info 
HCT15 SNV: p.G303V .
IM95 SNV: p.N492S DBIA    Probe Info 
JURKAT SNV: p.P112L .
LS123 SNV: p.D721A .
LS180 SNV: p.G687C .
MCAS SNV: p.S913N .
MCC13 SNV: p.Q164Ter .
MELJUSO Substitution: p.L742R .
MFE319 SNV: p.Q512Ter; p.Q520R .
NCIH1155 SNV: p.Y712Ter .
P31FUJ SNV: p.Y755H .
REH SNV: p.A996T .
SKMEL2 SNV: p.P715L .
SKMEL3 SNV: p.P575H .
SUPT1 SNV: p.S467N DBIA    Probe Info 
SW480 Insertion: p.R641delinsQLEENSRGC; p.E642AfsTer47 .
TOV21G SNV: p.L668M; p.P671T DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Probe 1
 Probe Info  		Y724(6.78); Y849(15.87)  LDD3495  [1]
Curcusone 37
 Probe Info  		2.31  LDD0188  [2]
HPAP
 Probe Info  		3.33  LDD0062  [3]
DBIA
 Probe Info  		C272(0.84)  LDD0078  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		C1151(0.00); C1199(0.00)  LDD0038  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [5]
IPM
 Probe Info  		N.A.  LDD0025  [6]
NAIA_5
 Probe Info  		C1199(0.00); C630(0.00)  LDD2224  [7]
TFBX
 Probe Info  		N.A.  LDD0027  [6]
AOyne
 Probe Info  		13.70  LDD0443  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C272(3.04)  LDD0372  [9]
 LDCM0214  AC1 PaTu 8988t C1151(0.51)  LDD1093  [4]
 LDCM0215  AC10 PaTu 8988t C1151(1.30)  LDD1094  [4]
 LDCM0216  AC100 HCT 116 C1151(0.73)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C1151(0.83)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C1151(0.81)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C1151(1.01)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C1151(0.91)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C1151(0.80)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C1151(0.94)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C1151(1.17)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C1151(0.73)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C1151(0.71)  LDD0542  [4]
 LDCM0226  AC11 PaTu 8988t C1151(1.29)  LDD1105  [4]
 LDCM0227  AC110 HCT 116 C1151(0.66)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C1151(0.83)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C1151(0.70)  LDD0546  [4]
 LDCM0230  AC113 HCT 116 C1151(0.97)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C1151(0.96)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C1151(1.16)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C1151(1.19)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C1151(1.03)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C1151(1.12)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C1151(1.05)  LDD0553  [4]
 LDCM0237  AC12 PaTu 8988t C1151(1.73)  LDD1116  [4]
 LDCM0238  AC120 HCT 116 C1151(0.98)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C1151(1.09)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C1151(1.67)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C1151(1.19)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C1151(0.88)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C1151(1.03)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C1151(1.19)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C1151(1.38)  LDD0562  [4]
 LDCM0246  AC128 PaTu 8988t C1151(1.18)  LDD1125  [4]
 LDCM0247  AC129 PaTu 8988t C1151(1.12)  LDD1126  [4]
 LDCM0249  AC130 PaTu 8988t C1151(0.91)  LDD1128  [4]
 LDCM0250  AC131 PaTu 8988t C1151(1.12)  LDD1129  [4]
 LDCM0251  AC132 PaTu 8988t C1151(1.14)  LDD1130  [4]
 LDCM0252  AC133 PaTu 8988t C1151(1.29)  LDD1131  [4]
 LDCM0253  AC134 PaTu 8988t C1151(1.28)  LDD1132  [4]
 LDCM0254  AC135 PaTu 8988t C1151(1.62)  LDD1133  [4]
 LDCM0255  AC136 PaTu 8988t C1151(1.49)  LDD1134  [4]
 LDCM0256  AC137 PaTu 8988t C1151(1.51)  LDD1135  [4]
 LDCM0257  AC138 PaTu 8988t C1151(1.05)  LDD1136  [4]
 LDCM0258  AC139 PaTu 8988t C1151(1.11)  LDD1137  [4]
 LDCM0259  AC14 PaTu 8988t C1151(1.39)  LDD1138  [4]
 LDCM0260  AC140 PaTu 8988t C1151(1.28)  LDD1139  [4]
 LDCM0261  AC141 PaTu 8988t C1151(1.13)  LDD1140  [4]
 LDCM0262  AC142 PaTu 8988t C1151(1.12)  LDD1141  [4]
 LDCM0270  AC15 PaTu 8988t C1151(1.54)  LDD1149  [4]
 LDCM0276  AC17 PaTu 8988t C1151(1.11)  LDD1155  [4]
 LDCM0277  AC18 PaTu 8988t C1151(1.10)  LDD1156  [4]
 LDCM0278  AC19 PaTu 8988t C1151(0.96)  LDD1157  [4]
 LDCM0279  AC2 PaTu 8988t C1151(0.49)  LDD1158  [4]
 LDCM0280  AC20 PaTu 8988t C1151(1.05)  LDD1159  [4]
 LDCM0281  AC21 PaTu 8988t C1151(1.20)  LDD1160  [4]
 LDCM0282  AC22 PaTu 8988t C1151(1.41)  LDD1161  [4]
 LDCM0283  AC23 PaTu 8988t C1151(1.63)  LDD1162  [4]
 LDCM0284  AC24 PaTu 8988t C1151(1.33)  LDD1163  [4]
 LDCM0285  AC25 HEK-293T C777(1.26); C1151(0.90)  LDD1524  [10]
 LDCM0286  AC26 HEK-293T C777(1.07); C1151(1.04)  LDD1525  [10]
 LDCM0287  AC27 HEK-293T C777(0.96); C1151(1.01)  LDD1526  [10]
 LDCM0288  AC28 HEK-293T C777(1.07); C1151(1.03)  LDD1527  [10]
 LDCM0289  AC29 HEK-293T C777(1.00); C1151(1.09); C1199(1.04)  LDD1528  [10]
 LDCM0290  AC3 PaTu 8988t C1151(0.42)  LDD1169  [4]
 LDCM0291  AC30 HEK-293T C777(1.05); C1151(0.86)  LDD1530  [10]
 LDCM0292  AC31 HEK-293T C777(0.99); C1151(0.99)  LDD1531  [10]
 LDCM0293  AC32 HEK-293T C777(0.96)  LDD1532  [10]
 LDCM0294  AC33 HEK-293T C777(1.07); C1151(0.98)  LDD1533  [10]
 LDCM0295  AC34 HEK-293T C777(1.09); C1151(0.97)  LDD1534  [10]
 LDCM0296  AC35 HEK-293T C777(0.94); C1151(1.07)  LDD1535  [10]
 LDCM0297  AC36 HEK-293T C777(1.14); C1151(1.00)  LDD1536  [10]
 LDCM0298  AC37 HEK-293T C777(1.01); C1151(0.99); C1199(1.04)  LDD1537  [10]
 LDCM0299  AC38 HEK-293T C777(1.06); C1151(0.90)  LDD1538  [10]
 LDCM0300  AC39 HEK-293T C777(1.06); C1151(1.07)  LDD1539  [10]
 LDCM0301  AC4 PaTu 8988t C1151(0.34)  LDD1180  [4]
 LDCM0302  AC40 HEK-293T C777(0.95)  LDD1541  [10]
 LDCM0303  AC41 HEK-293T C777(1.02); C1151(1.01)  LDD1542  [10]
 LDCM0304  AC42 HEK-293T C777(1.12); C1151(1.11)  LDD1543  [10]
 LDCM0305  AC43 HEK-293T C777(0.93); C1151(0.98)  LDD1544  [10]
 LDCM0306  AC44 HEK-293T C777(1.08); C1151(1.05)  LDD1545  [10]
 LDCM0307  AC45 HEK-293T C777(1.04); C1151(1.05); C1199(1.02)  LDD1546  [10]
 LDCM0308  AC46 HCT 116 C1151(1.02)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C1151(1.29)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C1151(1.49)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C1151(1.60)  LDD0628  [4]
 LDCM0312  AC5 PaTu 8988t C1151(0.50)  LDD1191  [4]
 LDCM0313  AC50 HCT 116 C1151(1.75)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C1151(1.25)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C1151(1.13)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C1151(1.18)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C1151(1.47)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C1151(1.45)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C1151(2.01)  LDD0636  [4]
 LDCM0320  AC57 HEK-293T C777(1.05); C1151(1.02)  LDD1559  [10]
 LDCM0321  AC58 HEK-293T C777(1.09); C1151(0.98)  LDD1560  [10]
 LDCM0322  AC59 HEK-293T C777(1.02); C1151(1.05)  LDD1561  [10]
 LDCM0323  AC6 PaTu 8988t C1151(1.11)  LDD1202  [4]
 LDCM0324  AC60 HEK-293T C777(1.09); C1151(1.03)  LDD1563  [10]
 LDCM0325  AC61 HEK-293T C777(1.07); C1151(1.13); C1199(1.09)  LDD1564  [10]
 LDCM0326  AC62 HEK-293T C777(1.10); C1151(1.00)  LDD1565  [10]
 LDCM0327  AC63 HEK-293T C777(1.05); C1151(1.01)  LDD1566  [10]
 LDCM0328  AC64 HEK-293T C777(0.95)  LDD1567  [10]
 LDCM0332  AC68 HCT 116 C1151(1.11)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C1151(1.43)  LDD0650  [4]
 LDCM0334  AC7 PaTu 8988t C1151(0.83)  LDD1213  [4]
 LDCM0335  AC70 HCT 116 C1151(1.35)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C1151(1.07)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C1151(1.24)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C1151(2.13)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C1151(1.90)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C1151(2.06)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C1151(1.33)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C1151(1.55)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C1151(1.24)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C1151(1.38)  LDD0661  [4]
 LDCM0345  AC8 PaTu 8988t C1151(1.16)  LDD1224  [4]
 LDCM0346  AC80 HCT 116 C1151(1.39)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C1151(1.81)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C1151(2.48)  LDD0665  [4]
 LDCM0365  AC98 HCT 116 C1151(1.53)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C1151(0.84)  LDD0683  [4]
 LDCM0248  AKOS034007472 PaTu 8988t C1151(1.70)  LDD1127  [4]
 LDCM0356  AKOS034007680 PaTu 8988t C1151(1.17)  LDD1235  [4]
 LDCM0275  AKOS034007705 PaTu 8988t C1151(1.55)  LDD1154  [4]
 LDCM0020  ARS-1620 HCC44 C272(0.84)  LDD0078  [4]
 LDCM0632  CL-Sc Hep-G2 C1199(1.95)  LDD2227  [7]
 LDCM0367  CL1 HEK-293T C777(0.94); C1151(1.04)  LDD1571  [10]
 LDCM0368  CL10 HEK-293T C777(0.76); C1151(0.98)  LDD1572  [10]
 LDCM0369  CL100 PaTu 8988t C1151(0.37)  LDD1248  [4]
 LDCM0370  CL101 PaTu 8988t C1151(1.07)  LDD1249  [4]
 LDCM0371  CL102 PaTu 8988t C1151(1.14)  LDD1250  [4]
 LDCM0372  CL103 PaTu 8988t C1151(1.54)  LDD1251  [4]
 LDCM0373  CL104 PaTu 8988t C1151(1.29)  LDD1252  [4]
 LDCM0374  CL105 PaTu 8988t C1151(1.18)  LDD1253  [4]
 LDCM0375  CL106 PaTu 8988t C1151(1.23)  LDD1254  [4]
 LDCM0376  CL107 PaTu 8988t C1151(1.64)  LDD1255  [4]
 LDCM0377  CL108 PaTu 8988t C1151(1.10)  LDD1256  [4]
 LDCM0378  CL109 PaTu 8988t C1151(1.22)  LDD1257  [4]
 LDCM0379  CL11 HEK-293T C777(0.94); C1151(1.00)  LDD1583  [10]
 LDCM0380  CL110 PaTu 8988t C1151(1.41)  LDD1259  [4]
 LDCM0381  CL111 PaTu 8988t C1151(1.54)  LDD1260  [4]
 LDCM0382  CL112 HEK-293T C777(1.08); C1151(0.97)  LDD1586  [10]
 LDCM0383  CL113 HEK-293T C777(0.89); C1151(1.07)  LDD1587  [10]
 LDCM0384  CL114 HEK-293T C777(1.08); C1151(1.01)  LDD1588  [10]
 LDCM0385  CL115 HEK-293T C777(1.09); C1151(1.05)  LDD1589  [10]
 LDCM0386  CL116 HEK-293T C777(1.06); C1151(1.03)  LDD1590  [10]
 LDCM0387  CL117 HEK-293T C777(0.97); C1151(0.98)  LDD1591  [10]
 LDCM0388  CL118 HEK-293T C777(1.17); C1151(1.06)  LDD1592  [10]
 LDCM0389  CL119 HEK-293T C777(1.02); C1151(1.06)  LDD1593  [10]
 LDCM0390  CL12 HEK-293T C777(0.78)  LDD1594  [10]
 LDCM0391  CL120 HEK-293T C777(1.08); C1151(1.05)  LDD1595  [10]
 LDCM0392  CL121 HCT 116 C1151(1.14)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C1151(1.51)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C1151(1.34)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C1151(1.55)  LDD0712  [4]
 LDCM0396  CL125 HEK-293T C777(0.79); C1151(1.05)  LDD1600  [10]
 LDCM0397  CL126 HEK-293T C777(1.07); C1151(1.05)  LDD1601  [10]
 LDCM0398  CL127 HEK-293T C777(1.14); C1151(1.13)  LDD1602  [10]
 LDCM0399  CL128 HEK-293T C777(1.04); C1151(1.12)  LDD1603  [10]
 LDCM0400  CL13 HEK-293T C777(1.04); C1151(1.25)  LDD1604  [10]
 LDCM0401  CL14 HEK-293T C777(1.22); C1151(0.97)  LDD1605  [10]
 LDCM0402  CL15 HEK-293T C777(1.00); C1151(1.06)  LDD1606  [10]
 LDCM0403  CL16 PaTu 8988t C1151(0.98)  LDD1282  [4]
 LDCM0404  CL17 PaTu 8988t C1151(0.93)  LDD1283  [4]
 LDCM0405  CL18 PaTu 8988t C1151(1.30)  LDD1284  [4]
 LDCM0406  CL19 PaTu 8988t C1151(1.28)  LDD1285  [4]
 LDCM0407  CL2 HEK-293T C777(1.21); C1151(1.03)  LDD1611  [10]
 LDCM0408  CL20 PaTu 8988t C1151(1.64)  LDD1287  [4]
 LDCM0409  CL21 PaTu 8988t C1151(2.27)  LDD1288  [4]
 LDCM0410  CL22 PaTu 8988t C1151(1.66)  LDD1289  [4]
 LDCM0411  CL23 PaTu 8988t C1151(1.23)  LDD1290  [4]
 LDCM0412  CL24 PaTu 8988t C1151(1.13)  LDD1291  [4]
 LDCM0413  CL25 PaTu 8988t C1151(0.97)  LDD1292  [4]
 LDCM0414  CL26 PaTu 8988t C1151(1.11)  LDD1293  [4]
 LDCM0415  CL27 PaTu 8988t C1151(0.91)  LDD1294  [4]
 LDCM0416  CL28 PaTu 8988t C1151(1.51)  LDD1295  [4]
 LDCM0417  CL29 PaTu 8988t C1151(1.62)  LDD1296  [4]
 LDCM0418  CL3 HEK-293T C777(1.16); C1151(1.05)  LDD1622  [10]
 LDCM0419  CL30 PaTu 8988t C1151(1.22)  LDD1298  [4]
 LDCM0420  CL31 HEK-293T C777(1.02); C1151(0.96)  LDD1624  [10]
 LDCM0421  CL32 HEK-293T C777(0.81); C1151(1.07)  LDD1625  [10]
 LDCM0422  CL33 HEK-293T C777(0.74); C1151(1.01); C1199(1.13)  LDD1626  [10]
 LDCM0423  CL34 HEK-293T C777(0.62); C1151(1.06)  LDD1627  [10]
 LDCM0424  CL35 HEK-293T C777(0.87); C1151(1.12)  LDD1628  [10]
 LDCM0425  CL36 HEK-293T C777(0.81)  LDD1629  [10]
 LDCM0426  CL37 HEK-293T C777(1.05); C1151(1.02)  LDD1630  [10]
 LDCM0428  CL39 HEK-293T C777(1.04); C1151(1.06)  LDD1632  [10]
 LDCM0429  CL4 HEK-293T C777(1.05); C1151(1.13)  LDD1633  [10]
 LDCM0430  CL40 HEK-293T C777(1.01); C1151(0.93)  LDD1634  [10]
 LDCM0431  CL41 HEK-293T C777(0.87); C1151(0.99)  LDD1635  [10]
 LDCM0432  CL42 HEK-293T C777(0.74); C1151(1.08)  LDD1636  [10]
 LDCM0433  CL43 HEK-293T C777(0.97); C1151(0.97)  LDD1637  [10]
 LDCM0434  CL44 HEK-293T C777(0.89); C1151(1.03)  LDD1638  [10]
 LDCM0435  CL45 HEK-293T C777(0.80); C1151(1.05); C1199(0.99)  LDD1639  [10]
 LDCM0436  CL46 PaTu 8988t C1151(1.03)  LDD1315  [4]
 LDCM0437  CL47 PaTu 8988t C1151(1.26)  LDD1316  [4]
 LDCM0438  CL48 PaTu 8988t C1151(1.10)  LDD1317  [4]
 LDCM0439  CL49 PaTu 8988t C1151(1.42)  LDD1318  [4]
 LDCM0440  CL5 HEK-293T C777(1.02); C1151(0.99)  LDD1644  [10]
 LDCM0441  CL50 PaTu 8988t C1151(1.11)  LDD1320  [4]
 LDCM0442  CL51 PaTu 8988t C1151(1.40)  LDD1321  [4]
 LDCM0443  CL52 PaTu 8988t C1151(1.31)  LDD1322  [4]
 LDCM0444  CL53 PaTu 8988t C1151(1.47)  LDD1323  [4]
 LDCM0445  CL54 PaTu 8988t C1151(1.07)  LDD1324  [4]
 LDCM0446  CL55 PaTu 8988t C1151(1.31)  LDD1325  [4]
 LDCM0447  CL56 PaTu 8988t C1151(1.18)  LDD1326  [4]
 LDCM0448  CL57 PaTu 8988t C1151(1.46)  LDD1327  [4]
 LDCM0449  CL58 PaTu 8988t C1151(1.12)  LDD1328  [4]
 LDCM0450  CL59 PaTu 8988t C1151(0.97)  LDD1329  [4]
 LDCM0451  CL6 HEK-293T C777(1.07); C1151(1.08)  LDD1654  [10]
 LDCM0452  CL60 PaTu 8988t C1151(1.46)  LDD1331  [4]
 LDCM0453  CL61 HEK-293T C777(0.88); C1151(1.04)  LDD1656  [10]
 LDCM0454  CL62 HEK-293T C777(1.33); C1151(0.97)  LDD1657  [10]
 LDCM0455  CL63 HEK-293T C777(1.09); C1151(1.12)  LDD1658  [10]
 LDCM0456  CL64 HEK-293T C777(1.06); C1151(1.06)  LDD1659  [10]
 LDCM0457  CL65 HEK-293T C777(0.94); C1151(1.04)  LDD1660  [10]
 LDCM0458  CL66 HEK-293T C777(0.90); C1151(1.04)  LDD1661  [10]
 LDCM0459  CL67 HEK-293T C777(1.00); C1151(1.07)  LDD1662  [10]
 LDCM0460  CL68 HEK-293T C777(0.86); C1151(1.14)  LDD1663  [10]
 LDCM0461  CL69 HEK-293T C777(0.85); C1151(1.03); C1199(0.99)  LDD1664  [10]
 LDCM0462  CL7 HEK-293T C777(1.09); C1151(1.02)  LDD1665  [10]
 LDCM0463  CL70 HEK-293T C777(0.79); C1151(0.98)  LDD1666  [10]
 LDCM0464  CL71 HEK-293T C777(0.94); C1151(1.02)  LDD1667  [10]
 LDCM0465  CL72 HEK-293T C777(0.91)  LDD1668  [10]
 LDCM0466  CL73 HEK-293T C777(0.85); C1151(1.06)  LDD1669  [10]
 LDCM0467  CL74 HEK-293T C777(1.15); C1151(1.02)  LDD1670  [10]
 LDCM0469  CL76 HEK-293T C777(0.98); C1151(0.99)  LDD1672  [10]
 LDCM0470  CL77 HEK-293T C777(0.45); C1151(0.84)  LDD1673  [10]
 LDCM0471  CL78 HEK-293T C777(0.93); C1151(1.02)  LDD1674  [10]
 LDCM0472  CL79 HEK-293T C777(1.00); C1151(1.05)  LDD1675  [10]
 LDCM0473  CL8 HEK-293T C777(0.74); C1151(0.88)  LDD1676  [10]
 LDCM0474  CL80 HEK-293T C777(0.90); C1151(1.10)  LDD1677  [10]
 LDCM0475  CL81 HEK-293T C777(0.86); C1151(1.02); C1199(0.93)  LDD1678  [10]
 LDCM0476  CL82 HEK-293T C777(0.80); C1151(0.92)  LDD1679  [10]
 LDCM0477  CL83 HEK-293T C777(1.00); C1151(0.97)  LDD1680  [10]
 LDCM0478  CL84 HEK-293T C777(0.84)  LDD1681  [10]
 LDCM0479  CL85 HEK-293T C777(0.94); C1151(1.17)  LDD1682  [10]
 LDCM0480  CL86 HEK-293T C777(1.25); C1151(1.00)  LDD1683  [10]
 LDCM0481  CL87 HEK-293T C777(1.00); C1151(1.17)  LDD1684  [10]
 LDCM0482  CL88 HEK-293T C777(0.99); C1151(1.18)  LDD1685  [10]
 LDCM0483  CL89 HEK-293T C777(1.07); C1151(1.01)  LDD1686  [10]
 LDCM0484  CL9 HEK-293T C777(0.81); C1151(1.10); C1199(0.94)  LDD1687  [10]
 LDCM0485  CL90 HEK-293T C777(0.89); C1151(1.07)  LDD1688  [10]
 LDCM0486  CL91 PaTu 8988t C1151(0.46)  LDD1365  [4]
 LDCM0487  CL92 PaTu 8988t C1151(0.39)  LDD1366  [4]
 LDCM0488  CL93 PaTu 8988t C1151(0.35)  LDD1367  [4]
 LDCM0489  CL94 PaTu 8988t C1151(0.35)  LDD1368  [4]
 LDCM0490  CL95 PaTu 8988t C1151(0.43)  LDD1369  [4]
 LDCM0491  CL96 PaTu 8988t C1151(0.38)  LDD1370  [4]
 LDCM0492  CL97 PaTu 8988t C1151(0.35)  LDD1371  [4]
 LDCM0493  CL98 PaTu 8988t C1151(0.54)  LDD1372  [4]
 LDCM0494  CL99 PaTu 8988t C1151(0.47)  LDD1373  [4]
 LDCM0033  Curcusone1d MCF-7 2.31  LDD0188  [2]
 LDCM0495  E2913 HEK-293T C777(1.12); C1151(1.00)  LDD1698  [10]
 LDCM0468  Fragment33 HEK-293T C777(1.16); C1151(1.08)  LDD1671  [10]
 LDCM0427  Fragment51 HEK-293T C777(1.11); C1151(1.16)  LDD1631  [10]
 LDCM0022  KB02 HEK-293T C1151(1.01); C777(1.01)  LDD1492  [10]
 LDCM0023  KB03 HEK-293T C1151(1.06); C777(0.99)  LDD1497  [10]
 LDCM0024  KB05 COLO792 C1151(1.64)  LDD3310  [11]
 LDCM0014  Panhematin HEK-293T 3.33  LDD0062  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
TNF receptor-associated factor 2 (TRAF2) TNF receptor-associated factor family Q12933
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
RalA-binding protein 1 (RALBP1) . Q15311
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
REST corepressor 3 (RCOR3) CoREST family Q9P2K3
Other
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cilia- and flagella-associated protein 206 (CFAP206) CFAP206 family Q8IYR0
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Tektin-4 (TEKT4) Tektin family Q8WW24
Tuftelin-interacting protein 11 (TFIP11) TFP11/STIP family Q9UBB9
Thyroid receptor-interacting protein 6 (TRIP6) Zyxin/ajuba family Q15654
Caspase recruitment domain-containing protein 10 (CARD10) . Q9BWT7
Leukocyte receptor cluster member 8 (LENG8) . Q96PV6
RNA-binding protein with multiple splicing (RBPMS) . Q93062
Uncharacterized protein C1orf94 (C1orf94) . Q6P1W5
Zinc finger MYND domain-containing protein 19 (ZMYND19) . Q96E35

References

1 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
2 Total Synthesis and Target Identification of the Curcusone Diterpenes. J Am Chem Soc. 2021 Mar 24;143(11):4379-4386. doi: 10.1021/jacs.1c00557. Epub 2021 Mar 11.
3 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
11 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840