Details of the Target

General Information of Target

Target ID LDTP02096
Target Name Propionyl-CoA carboxylase beta chain, mitochondrial (PCCB)
Gene Name PCCB
Gene ID 5096
Synonyms
Propionyl-CoA carboxylase beta chain, mitochondrial; PCCase subunit beta; EC 6.4.1.3; Propanoyl-CoA:carbon dioxide ligase subunit beta
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAALRVAAVGARLSVLASGLRAAVRSLCSQATSVNERIENKRRTALLGGGQRRIDAQHK
RGKLTARERISLLLDPGSFVESDMFVEHRCADFGMAADKNKFPGDSVVTGRGRINGRLVY
VFSQDFTVFGGSLSGAHAQKICKIMDQAITVGAPVIGLNDSGGARIQEGVESLAGYADIF
LRNVTASGVIPQISLIMGPCAGGAVYSPALTDFTFMVKDTSYLFITGPDVVKSVTNEDVT
QEELGGAKTHTTMSGVAHRAFENDVDALCNLRDFFNYLPLSSQDPAPVRECHDPSDRLVP
ELDTIVPLESTKAYNMVDIIHSVVDEREFFEIMPNYAKNIIVGFARMNGRTVGIVGNQPK
VASGCLDINSSVKGARFVRFCDAFNIPLITFVDVPGFLPGTAQEYGGIIRHGAKLLYAFA
EATVPKVTVITRKAYGGAYDVMSSKHLCGDTNYAWPTAEIAVMGAKGAVEIIFKGHENVE
AAQAEYIEKFANPFPAAVRGFVDDIIQPSSTRARICCDLDVLASKKVQRPWRKHANIPL
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
AccD/PCCB family
Subcellular location
Mitochondrion matrix
Function
This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and valine and other metabolites. Propionyl-CoA carboxylase catalyzes the carboxylation of propionyl-CoA/propanoyl-CoA to D-methylmalonyl-CoA/(S)-methylmalonyl-CoA. Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain, while the beta subunit then transfers the carboxyl group from carboxylated biotin to propionyl-CoA. Propionyl-CoA carboxylase also significantly acts on butyryl-CoA/butanoyl-CoA, which is converted to ethylmalonyl-CoA/(2S)-ethylmalonyl-CoA at a much lower rate. Other alternative minor substrates include (2E)-butenoyl-CoA/crotonoyl-CoA.
TTD ID
T63213
Uniprot ID
P05166
DrugMap ID
TT5LURU
Ensemble ID
ENST00000251654.9
HGNC ID
HGNC:8654

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A2780 SNV: p.R376G DBIA    Probe Info 
MFE296 Insertion: p.L210SfsTer21 DBIA    Probe Info 
SBC5 SNV: p.P287S DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 22 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		11.36  LDD0402  [1]
YN-1
 Probe Info  		100.00  LDD0444  [2]
BTD
 Probe Info  		C517(4.14)  LDD1699  [3]
DBIA
 Probe Info  		C311(1.84)  LDD3310  [4]
Curcusone 37
 Probe Info  		2.01  LDD0188  [5]
Jackson_14
 Probe Info  		2.08  LDD0123  [6]
AHL-Pu-1
 Probe Info  		C269(4.13)  LDD0170  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		C269(0.00); C365(0.00); C448(0.00); C90(0.00)  LDD0038  [8]
IA-alkyne
 Probe Info  		C269(0.00); C381(0.00); C448(0.00); C200(0.00)  LDD0036  [8]
Lodoacetamide azide
 Probe Info  		C269(0.00); C448(0.00); C90(0.00); C381(0.00)  LDD0037  [8]
IPM
 Probe Info  		N.A.  LDD0025  [9]
JW-RF-010
 Probe Info  		C516(0.00); C517(0.00)  LDD0026  [9]
TFBX
 Probe Info  		N.A.  LDD0027  [9]
WYneO
 Probe Info  		N.A.  LDD0022  [10]
Compound 10
 Probe Info  		C269(0.00); C365(0.00)  LDD2216  [11]
Compound 11
 Probe Info  		N.A.  LDD2213  [11]
VSF
 Probe Info  		N.A.  LDD0007  [10]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [12]
Acrolein
 Probe Info  		C269(0.00); C517(0.00); C365(0.00)  LDD0217  [13]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [13]
AOyne
 Probe Info  		15.00  LDD0443  [14]
NAIA_5
 Probe Info  		C381(0.00); C365(0.00)  LDD2223  [15]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C050
 Probe Info  		6.77  LDD1748  [16]
STS-1
 Probe Info  		N.A.  LDD0068  [17]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C269(0.67)  LDD2142  [3]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C365(0.90); C269(0.83)  LDD2112  [3]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C365(1.17)  LDD2130  [3]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C365(0.78)  LDD2103  [3]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C365(0.63)  LDD2132  [3]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C365(0.89)  LDD2131  [3]
 LDCM0025  4SU-RNA DM93 C269(4.13)  LDD0170  [7]
 LDCM0214  AC1 HEK-293T C269(0.93); C90(1.01); C448(0.95); C291(0.96)  LDD1507  [18]
 LDCM0215  AC10 HEK-293T C365(0.96); C269(0.97); C90(1.01); C448(0.93)  LDD1508  [18]
 LDCM0226  AC11 HEK-293T C365(0.93); C269(1.03); C90(1.06); C448(0.93)  LDD1509  [18]
 LDCM0237  AC12 HEK-293T C365(0.83); C269(0.97); C90(1.07); C448(1.03)  LDD1510  [18]
 LDCM0259  AC14 HEK-293T C365(1.03); C269(0.99); C90(1.13); C291(0.95)  LDD1512  [18]
 LDCM0270  AC15 HEK-293T C365(1.03); C269(0.86); C90(1.11); C448(0.98)  LDD1513  [18]
 LDCM0276  AC17 HEK-293T C269(0.87); C90(1.05); C448(1.05); C291(0.93)  LDD1515  [18]
 LDCM0277  AC18 HEK-293T C365(0.93); C269(0.95); C90(0.98); C448(1.07)  LDD1516  [18]
 LDCM0278  AC19 HEK-293T C365(1.09); C269(0.98); C90(1.08); C448(0.84)  LDD1517  [18]
 LDCM0279  AC2 HEK-293T C365(1.01); C269(0.96); C90(1.03); C448(1.04)  LDD1518  [18]
 LDCM0280  AC20 HEK-293T C365(0.90); C269(0.99); C90(1.00); C448(0.98)  LDD1519  [18]
 LDCM0281  AC21 HEK-293T C365(1.04); C269(0.99); C90(1.10); C291(1.07)  LDD1520  [18]
 LDCM0282  AC22 HEK-293T C365(0.93); C269(1.10); C90(1.09); C291(0.99)  LDD1521  [18]
 LDCM0283  AC23 HEK-293T C365(0.96); C269(0.91); C90(1.05); C448(1.02)  LDD1522  [18]
 LDCM0284  AC24 HEK-293T C365(1.03); C269(0.99); C90(0.99); C291(1.00)  LDD1523  [18]
 LDCM0285  AC25 HEK-293T C269(0.90); C90(1.06); C448(0.94); C291(1.02)  LDD1524  [18]
 LDCM0286  AC26 HEK-293T C365(0.96); C269(0.89); C90(1.04); C448(0.90)  LDD1525  [18]
 LDCM0287  AC27 HEK-293T C365(0.94); C269(0.99); C90(1.04); C448(0.89)  LDD1526  [18]
 LDCM0288  AC28 HEK-293T C365(0.89); C269(1.03); C90(1.05); C448(0.98)  LDD1527  [18]
 LDCM0289  AC29 HEK-293T C365(1.07); C269(0.96); C90(1.16); C291(1.09)  LDD1528  [18]
 LDCM0290  AC3 HEK-293T C365(0.92); C269(0.98); C90(0.94); C448(0.91)  LDD1529  [18]
 LDCM0291  AC30 HEK-293T C365(1.02); C269(1.10); C90(1.07); C291(0.93)  LDD1530  [18]
 LDCM0292  AC31 HEK-293T C365(0.69); C269(0.75); C90(1.01); C448(0.89)  LDD1531  [18]
 LDCM0293  AC32 HEK-293T C365(1.04); C269(1.09); C90(0.97); C291(1.06)  LDD1532  [18]
 LDCM0294  AC33 HEK-293T C269(0.99); C90(1.01); C448(0.88); C291(0.99)  LDD1533  [18]
 LDCM0295  AC34 HEK-293T C365(1.04); C269(0.96); C90(1.04); C448(0.95)  LDD1534  [18]
 LDCM0296  AC35 HEK-293T C365(0.85); C269(0.98); C90(1.00); C448(0.90)  LDD1535  [18]
 LDCM0297  AC36 HEK-293T C365(0.91); C269(1.00); C90(1.21); C448(0.92)  LDD1536  [18]
 LDCM0298  AC37 HEK-293T C365(1.12); C269(1.05); C90(0.99); C291(1.15)  LDD1537  [18]
 LDCM0299  AC38 HEK-293T C365(1.07); C269(1.00); C90(1.09); C291(0.99)  LDD1538  [18]
 LDCM0300  AC39 HEK-293T C365(1.02); C269(0.88); C90(1.17); C448(0.96)  LDD1539  [18]
 LDCM0301  AC4 HEK-293T C365(1.03); C269(0.96); C90(1.10); C448(1.03)  LDD1540  [18]
 LDCM0302  AC40 HEK-293T C365(1.10); C269(0.98); C90(0.97); C291(1.02)  LDD1541  [18]
 LDCM0303  AC41 HEK-293T C269(0.95); C90(1.02); C448(1.00); C291(0.96)  LDD1542  [18]
 LDCM0304  AC42 HEK-293T C365(1.00); C269(0.91); C90(1.07); C448(0.98)  LDD1543  [18]
 LDCM0305  AC43 HEK-293T C365(0.91); C269(1.06); C90(0.99); C448(0.87)  LDD1544  [18]
 LDCM0306  AC44 HEK-293T C365(0.83); C269(1.05); C90(1.05); C448(0.97)  LDD1545  [18]
 LDCM0307  AC45 HEK-293T C365(0.92); C269(0.96); C90(1.14); C291(1.01)  LDD1546  [18]
 LDCM0308  AC46 HEK-293T C365(0.98); C269(0.99); C90(1.09); C291(0.95)  LDD1547  [18]
 LDCM0309  AC47 HEK-293T C365(1.04); C269(0.96); C90(1.10); C448(0.92)  LDD1548  [18]
 LDCM0310  AC48 HEK-293T C365(1.06); C269(0.95); C90(1.01); C291(1.02)  LDD1549  [18]
 LDCM0311  AC49 HEK-293T C269(0.98); C90(1.03); C448(0.93); C291(0.95)  LDD1550  [18]
 LDCM0312  AC5 HEK-293T C365(1.00); C269(0.95); C90(1.02); C291(1.02)  LDD1551  [18]
 LDCM0313  AC50 HEK-293T C365(1.05); C269(0.96); C90(0.97); C448(0.97)  LDD1552  [18]
 LDCM0314  AC51 HEK-293T C365(1.08); C269(1.03); C90(0.93); C448(0.94)  LDD1553  [18]
 LDCM0315  AC52 HEK-293T C365(0.87); C269(0.94); C90(1.09); C448(0.94)  LDD1554  [18]
 LDCM0316  AC53 HEK-293T C365(1.00); C269(0.88); C90(1.06); C291(1.09)  LDD1555  [18]
 LDCM0317  AC54 HEK-293T C365(0.94); C269(1.05); C90(1.20); C291(0.96)  LDD1556  [18]
 LDCM0318  AC55 HEK-293T C365(0.99); C269(0.90); C90(1.16); C448(0.91)  LDD1557  [18]
 LDCM0319  AC56 HEK-293T C365(1.14); C269(0.98); C90(0.92); C291(0.99)  LDD1558  [18]
 LDCM0320  AC57 HEK-293T C269(0.96); C90(1.04); C448(0.92); C291(0.91)  LDD1559  [18]
 LDCM0321  AC58 HEK-293T C365(0.99); C269(0.91); C90(0.98); C448(0.90)  LDD1560  [18]
 LDCM0322  AC59 HEK-293T C365(0.93); C269(0.90); C90(1.03); C448(0.93)  LDD1561  [18]
 LDCM0323  AC6 HEK-293T C365(0.96); C269(1.02); C90(1.01); C291(1.00)  LDD1562  [18]
 LDCM0324  AC60 HEK-293T C365(0.88); C269(1.00); C90(1.06); C448(1.03)  LDD1563  [18]
 LDCM0325  AC61 HEK-293T C365(1.08); C269(0.96); C90(1.02); C291(1.00)  LDD1564  [18]
 LDCM0326  AC62 HEK-293T C365(0.98); C269(1.03); C90(1.06); C291(0.94)  LDD1565  [18]
 LDCM0327  AC63 HEK-293T C365(1.06); C269(0.98); C90(1.05); C448(0.99)  LDD1566  [18]
 LDCM0328  AC64 HEK-293T C365(1.12); C269(0.99); C90(0.94); C291(0.98)  LDD1567  [18]
 LDCM0334  AC7 HEK-293T C365(0.77); C269(0.88); C90(1.05); C448(0.98)  LDD1568  [18]
 LDCM0345  AC8 HEK-293T C365(1.08); C269(1.03); C90(0.99); C291(1.06)  LDD1569  [18]
 LDCM0520  AKOS000195272 MDA-MB-231 C365(0.81)  LDD2113  [3]
 LDCM0248  AKOS034007472 HEK-293T C365(1.01); C269(0.94); C90(1.07); C291(1.16)  LDD1511  [18]
 LDCM0356  AKOS034007680 HEK-293T C269(1.00); C90(1.03); C448(1.01); C291(0.94)  LDD1570  [18]
 LDCM0275  AKOS034007705 HEK-293T C365(1.02); C269(1.00); C90(1.00); C291(1.04)  LDD1514  [18]
 LDCM0108  Chloroacetamide HeLa C269(0.00); C517(0.00)  LDD0222  [13]
 LDCM0367  CL1 HEK-293T C365(0.97); C269(0.96); C90(0.94); C448(0.96)  LDD1571  [18]
 LDCM0368  CL10 HEK-293T C365(1.41); C269(1.22); C90(1.13); C291(0.90)  LDD1572  [18]
 LDCM0369  CL100 HEK-293T C365(1.07); C269(0.91); C90(1.11); C448(1.19)  LDD1573  [18]
 LDCM0370  CL101 HEK-293T C365(0.90); C269(1.04); C90(0.99); C448(1.01)  LDD1574  [18]
 LDCM0371  CL102 HEK-293T C269(1.02); C90(1.01); C448(0.99); C291(0.95)  LDD1575  [18]
 LDCM0372  CL103 HEK-293T C269(1.00); C90(0.99); C291(1.03); C200(1.01)  LDD1576  [18]
 LDCM0373  CL104 HEK-293T C365(1.01); C269(1.03); C90(1.05); C448(1.03)  LDD1577  [18]
 LDCM0374  CL105 HEK-293T C365(1.10); C269(1.08); C90(0.99); C448(1.02)  LDD1578  [18]
 LDCM0375  CL106 HEK-293T C269(1.00); C90(1.05); C448(0.94); C291(1.00)  LDD1579  [18]
 LDCM0376  CL107 HEK-293T C269(0.99); C90(1.04); C291(0.99); C200(1.16)  LDD1580  [18]
 LDCM0377  CL108 HEK-293T C365(0.95); C269(1.01); C90(1.06); C448(0.95)  LDD1581  [18]
 LDCM0378  CL109 HEK-293T C365(0.96); C269(0.97); C90(0.97); C448(0.98)  LDD1582  [18]
 LDCM0379  CL11 HEK-293T C365(0.96); C269(0.99); C90(1.23); C448(0.95)  LDD1583  [18]
 LDCM0380  CL110 HEK-293T C269(0.86); C90(1.14); C448(0.92); C291(0.98)  LDD1584  [18]
 LDCM0381  CL111 HEK-293T C269(0.91); C90(1.04); C291(0.93); C200(0.86)  LDD1585  [18]
 LDCM0382  CL112 HEK-293T C365(0.97); C269(0.95); C90(1.09); C448(1.01)  LDD1586  [18]
 LDCM0383  CL113 HEK-293T C365(0.94); C269(0.99); C90(0.95); C448(1.01)  LDD1587  [18]
 LDCM0384  CL114 HEK-293T C269(0.88); C90(1.16); C448(0.95); C291(0.91)  LDD1588  [18]
 LDCM0385  CL115 HEK-293T C269(0.95); C90(1.04); C291(0.93); C200(1.00)  LDD1589  [18]
 LDCM0386  CL116 HEK-293T C365(1.06); C269(1.08); C90(1.06); C448(0.98)  LDD1590  [18]
 LDCM0387  CL117 HEK-293T C365(0.93); C269(0.94); C90(1.01); C448(1.05)  LDD1591  [18]
 LDCM0388  CL118 HEK-293T C269(0.99); C90(1.00); C448(1.00); C291(1.06)  LDD1592  [18]
 LDCM0389  CL119 HEK-293T C269(0.97); C90(1.08); C291(0.98); C200(1.06)  LDD1593  [18]
 LDCM0390  CL12 HEK-293T C365(1.16); C269(0.94); C90(0.90); C291(1.00)  LDD1594  [18]
 LDCM0391  CL120 HEK-293T C365(0.99); C269(1.06); C90(1.05); C448(0.92)  LDD1595  [18]
 LDCM0392  CL121 HEK-293T C365(0.98); C269(0.96); C90(1.00); C448(0.98)  LDD1596  [18]
 LDCM0393  CL122 HEK-293T C269(1.03); C90(1.06); C448(0.98); C291(0.89)  LDD1597  [18]
 LDCM0394  CL123 HEK-293T C269(1.01); C90(1.02); C291(0.87); C200(0.93)  LDD1598  [18]
 LDCM0395  CL124 HEK-293T C365(1.06); C269(0.98); C90(0.95); C448(1.06)  LDD1599  [18]
 LDCM0396  CL125 HEK-293T C365(0.97); C269(0.97); C90(0.92); C448(0.92)  LDD1600  [18]
 LDCM0397  CL126 HEK-293T C269(0.92); C90(0.98); C448(0.94); C291(0.92)  LDD1601  [18]
 LDCM0398  CL127 HEK-293T C269(0.91); C90(1.04); C291(0.96); C200(1.20)  LDD1602  [18]
 LDCM0399  CL128 HEK-293T C365(1.03); C269(0.95); C90(1.01); C448(1.05)  LDD1603  [18]
 LDCM0400  CL13 HEK-293T C365(0.98); C269(0.98); C90(0.94); C448(0.98)  LDD1604  [18]
 LDCM0401  CL14 HEK-293T C269(1.10); C90(1.04); C448(0.93); C291(1.00)  LDD1605  [18]
 LDCM0402  CL15 HEK-293T C269(1.00); C90(0.96); C291(0.99); C200(1.02)  LDD1606  [18]
 LDCM0403  CL16 HEK-293T C365(1.07); C269(0.95); C90(1.03); C448(1.09)  LDD1607  [18]
 LDCM0404  CL17 HEK-293T C269(0.97); C90(1.10); C448(0.91); C291(0.80)  LDD1608  [18]
 LDCM0405  CL18 HEK-293T C365(0.97); C269(0.99); C90(0.99); C448(1.06)  LDD1609  [18]
 LDCM0406  CL19 HEK-293T C365(1.10); C269(0.97); C90(1.03); C448(0.95)  LDD1610  [18]
 LDCM0407  CL2 HEK-293T C269(1.15); C90(1.02); C448(0.97); C291(1.03)  LDD1611  [18]
 LDCM0408  CL20 HEK-293T C365(0.92); C269(1.01); C90(1.24); C448(1.06)  LDD1612  [18]
 LDCM0409  CL21 HEK-293T C365(1.55); C269(0.95); C90(1.05); C291(0.94)  LDD1613  [18]
 LDCM0410  CL22 HEK-293T C365(1.00); C269(1.04); C90(1.16); C291(1.03)  LDD1614  [18]
 LDCM0411  CL23 HEK-293T C365(1.28); C269(0.91); C90(1.27); C448(1.09)  LDD1615  [18]
 LDCM0412  CL24 HEK-293T C365(1.24); C269(1.03); C90(1.02); C291(1.04)  LDD1616  [18]
 LDCM0413  CL25 HEK-293T C365(1.06); C269(1.06); C90(0.96); C448(0.92)  LDD1617  [18]
 LDCM0414  CL26 HEK-293T C269(1.02); C90(1.00); C448(1.09); C291(1.04)  LDD1618  [18]
 LDCM0415  CL27 HEK-293T C269(0.91); C90(1.02); C291(1.13); C200(0.79)  LDD1619  [18]
 LDCM0416  CL28 HEK-293T C365(1.03); C269(0.93); C90(1.02); C448(0.99)  LDD1620  [18]
 LDCM0417  CL29 HEK-293T C269(0.88); C90(0.98); C448(0.93); C291(0.99)  LDD1621  [18]
 LDCM0418  CL3 HEK-293T C269(1.07); C90(1.15); C291(1.01); C200(0.92)  LDD1622  [18]
 LDCM0419  CL30 HEK-293T C365(0.92); C269(1.01); C90(1.06); C448(1.03)  LDD1623  [18]
 LDCM0420  CL31 HEK-293T C365(0.87); C269(1.04); C90(1.15); C448(0.93)  LDD1624  [18]
 LDCM0421  CL32 HEK-293T C365(0.95); C269(0.90); C90(1.12); C448(0.96)  LDD1625  [18]
 LDCM0422  CL33 HEK-293T C365(1.68); C269(0.84); C90(1.30); C291(1.06)  LDD1626  [18]
 LDCM0423  CL34 HEK-293T C365(1.03); C269(1.07); C90(1.07); C291(0.96)  LDD1627  [18]
 LDCM0424  CL35 HEK-293T C365(1.20); C269(0.98); C90(1.20); C448(1.00)  LDD1628  [18]
 LDCM0425  CL36 HEK-293T C365(1.40); C269(0.95); C90(0.97); C291(1.01)  LDD1629  [18]
 LDCM0426  CL37 HEK-293T C365(1.17); C269(1.02); C90(0.97); C448(0.99)  LDD1630  [18]
 LDCM0428  CL39 HEK-293T C269(0.93); C90(1.02); C291(0.95); C200(1.29)  LDD1632  [18]
 LDCM0429  CL4 HEK-293T C365(1.15); C269(0.98); C90(1.04); C448(1.14)  LDD1633  [18]
 LDCM0430  CL40 HEK-293T C365(0.91); C269(1.08); C90(1.11); C448(1.11)  LDD1634  [18]
 LDCM0431  CL41 HEK-293T C269(0.93); C90(1.07); C448(0.89); C291(0.90)  LDD1635  [18]
 LDCM0432  CL42 HEK-293T C365(0.94); C269(0.95); C90(1.05); C448(1.00)  LDD1636  [18]
 LDCM0433  CL43 HEK-293T C365(0.95); C269(1.03); C90(0.99); C448(0.95)  LDD1637  [18]
 LDCM0434  CL44 HEK-293T C365(0.85); C269(0.95); C90(1.10); C448(1.06)  LDD1638  [18]
 LDCM0435  CL45 HEK-293T C365(1.20); C269(1.02); C90(1.11); C291(1.02)  LDD1639  [18]
 LDCM0436  CL46 HEK-293T C365(1.03); C269(1.10); C90(1.19); C291(1.02)  LDD1640  [18]
 LDCM0437  CL47 HEK-293T C365(0.94); C269(0.97); C90(1.09); C448(1.03)  LDD1641  [18]
 LDCM0438  CL48 HEK-293T C365(1.15); C269(1.01); C90(1.03); C291(1.03)  LDD1642  [18]
 LDCM0439  CL49 HEK-293T C365(1.13); C269(1.05); C90(0.98); C448(0.99)  LDD1643  [18]
 LDCM0440  CL5 HEK-293T C269(0.92); C90(1.12); C448(1.09); C291(0.93)  LDD1644  [18]
 LDCM0441  CL50 HEK-293T C269(0.93); C90(1.06); C448(0.96); C291(0.99)  LDD1645  [18]
 LDCM0443  CL52 HEK-293T C365(1.04); C269(1.07); C90(1.03); C448(1.12)  LDD1646  [18]
 LDCM0444  CL53 HEK-293T C269(0.89); C90(1.10); C448(0.95); C291(0.86)  LDD1647  [18]
 LDCM0445  CL54 HEK-293T C365(1.53); C269(1.03); C90(1.04); C448(1.07)  LDD1648  [18]
 LDCM0446  CL55 HEK-293T C365(1.09); C269(0.99); C90(0.94); C448(0.90)  LDD1649  [18]
 LDCM0447  CL56 HEK-293T C365(0.99); C269(1.00); C90(1.09); C448(1.05)  LDD1650  [18]
 LDCM0448  CL57 HEK-293T C365(1.63); C269(0.92); C90(1.02); C291(1.18)  LDD1651  [18]
 LDCM0449  CL58 HEK-293T C365(1.06); C269(1.03); C90(1.11); C291(0.97)  LDD1652  [18]
 LDCM0450  CL59 HEK-293T C365(1.07); C269(0.89); C90(1.23); C448(1.00)  LDD1653  [18]
 LDCM0451  CL6 HEK-293T C365(1.32); C269(0.87); C90(1.05); C448(1.17)  LDD1654  [18]
 LDCM0452  CL60 HEK-293T C365(1.30); C269(0.95); C90(1.08); C291(1.01)  LDD1655  [18]
 LDCM0453  CL61 HEK-293T C365(1.15); C269(1.01); C90(0.91); C448(0.95)  LDD1656  [18]
 LDCM0454  CL62 HEK-293T C269(0.98); C90(1.03); C448(0.96); C291(1.01)  LDD1657  [18]
 LDCM0455  CL63 HEK-293T C269(1.05); C90(1.17); C291(1.02); C200(1.22)  LDD1658  [18]
 LDCM0456  CL64 HEK-293T C365(1.26); C269(0.93); C90(1.05); C448(0.98)  LDD1659  [18]
 LDCM0457  CL65 HEK-293T C269(0.92); C90(1.09); C448(0.87); C291(0.98)  LDD1660  [18]
 LDCM0458  CL66 HEK-293T C365(0.95); C269(0.94); C90(1.08); C448(1.01)  LDD1661  [18]
 LDCM0459  CL67 HEK-293T C365(0.92); C269(1.13); C90(1.08); C448(0.92)  LDD1662  [18]
 LDCM0460  CL68 HEK-293T C365(0.95); C269(1.03); C90(1.15); C448(1.04)  LDD1663  [18]
 LDCM0461  CL69 HEK-293T C365(1.11); C269(0.93); C90(1.05); C291(1.05)  LDD1664  [18]
 LDCM0462  CL7 HEK-293T C365(1.07); C269(1.02); C90(0.96); C448(0.99)  LDD1665  [18]
 LDCM0463  CL70 HEK-293T C365(1.00); C269(1.10); C90(1.14); C291(1.00)  LDD1666  [18]
 LDCM0464  CL71 HEK-293T C365(0.99); C269(0.95); C90(1.24); C448(1.08)  LDD1667  [18]
 LDCM0465  CL72 HEK-293T C365(1.22); C269(1.01); C90(0.98); C291(1.02)  LDD1668  [18]
 LDCM0466  CL73 HEK-293T C365(1.06); C269(0.80); C90(0.93); C448(0.94)  LDD1669  [18]
 LDCM0467  CL74 HEK-293T C269(0.95); C90(0.98); C448(0.98); C291(1.00)  LDD1670  [18]
 LDCM0469  CL76 HEK-293T C365(1.04); C269(1.06); C90(0.98); C448(0.94)  LDD1672  [18]
 LDCM0470  CL77 HEK-293T C269(0.85); C90(1.10); C448(0.95); C291(0.86)  LDD1673  [18]
 LDCM0471  CL78 HEK-293T C365(1.03); C269(0.97); C90(1.06); C448(1.02)  LDD1674  [18]
 LDCM0472  CL79 HEK-293T C365(1.15); C269(0.95); C90(1.09); C448(1.00)  LDD1675  [18]
 LDCM0473  CL8 HEK-293T C365(1.59); C269(0.85); C90(1.24); C448(0.78)  LDD1676  [18]
 LDCM0474  CL80 HEK-293T C365(0.90); C269(0.95); C90(1.07); C448(1.10)  LDD1677  [18]
 LDCM0475  CL81 HEK-293T C365(1.01); C269(0.97); C90(1.04); C291(1.11)  LDD1678  [18]
 LDCM0476  CL82 HEK-293T C365(1.01); C269(1.19); C90(1.09); C291(0.96)  LDD1679  [18]
 LDCM0477  CL83 HEK-293T C365(1.03); C269(0.98); C90(1.17); C448(1.00)  LDD1680  [18]
 LDCM0478  CL84 HEK-293T C365(1.31); C269(0.97); C90(1.02); C291(1.01)  LDD1681  [18]
 LDCM0479  CL85 HEK-293T C365(0.94); C269(0.96); C90(0.95); C448(0.86)  LDD1682  [18]
 LDCM0480  CL86 HEK-293T C269(1.02); C90(1.00); C448(0.95); C291(1.05)  LDD1683  [18]
 LDCM0481  CL87 HEK-293T C269(0.94); C90(1.01); C291(0.99); C200(1.08)  LDD1684  [18]
 LDCM0482  CL88 HEK-293T C365(1.02); C269(1.03); C90(1.02); C448(1.01)  LDD1685  [18]
 LDCM0483  CL89 HEK-293T C269(0.96); C90(1.04); C448(1.01); C291(1.04)  LDD1686  [18]
 LDCM0484  CL9 HEK-293T C365(1.31); C269(0.99); C90(0.98); C291(1.16)  LDD1687  [18]
 LDCM0485  CL90 HEK-293T C365(1.89); C269(0.84); C90(1.00); C448(0.92)  LDD1688  [18]
 LDCM0486  CL91 HEK-293T C365(1.00); C269(1.07); C90(0.95); C448(0.97)  LDD1689  [18]
 LDCM0487  CL92 HEK-293T C365(0.97); C269(0.88); C90(1.02); C448(1.02)  LDD1690  [18]
 LDCM0488  CL93 HEK-293T C365(1.17); C269(0.95); C90(1.08); C291(0.95)  LDD1691  [18]
 LDCM0489  CL94 HEK-293T C365(0.98); C269(1.01); C90(1.12); C291(0.95)  LDD1692  [18]
 LDCM0490  CL95 HEK-293T C365(1.02); C269(0.85); C90(1.18); C448(0.84)  LDD1693  [18]
 LDCM0491  CL96 HEK-293T C365(1.41); C269(0.92); C90(0.97); C291(0.95)  LDD1694  [18]
 LDCM0492  CL97 HEK-293T C365(1.01); C269(0.96); C90(1.01); C448(0.98)  LDD1695  [18]
 LDCM0493  CL98 HEK-293T C269(0.93); C90(0.96); C448(1.06); C291(0.94)  LDD1696  [18]
 LDCM0494  CL99 HEK-293T C269(1.01); C90(1.00); C291(0.95); C200(1.06)  LDD1697  [18]
 LDCM0033  Curcusone1d MCF-7 2.01  LDD0188  [5]
 LDCM0495  E2913 HEK-293T C269(0.97); C90(0.95); C291(1.15); C200(0.82)  LDD1698  [18]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C365(2.33); C269(1.16); C517(0.83)  LDD1702  [3]
 LDCM0468  Fragment33 HEK-293T C269(0.99); C90(1.04); C291(1.01); C200(1.06)  LDD1671  [18]
 LDCM0427  Fragment51 HEK-293T C269(0.94); C90(0.95); C448(0.88); C291(0.99)  LDD1631  [18]
 LDCM0107  IAA HeLa N.A.  LDD0221  [13]
 LDCM0022  KB02 HEK-293T C291(1.07); C269(0.96); C448(0.91); C517(1.06)  LDD1492  [18]
 LDCM0023  KB03 HEK-293T C291(1.03); C269(0.95); C448(1.02); C517(0.95)  LDD1497  [18]
 LDCM0024  KB05 COLO792 C311(1.84)  LDD3310  [4]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C365(1.07)  LDD2102  [3]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C365(0.94)  LDD2121  [3]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C365(1.56)  LDD2090  [3]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C365(1.01)  LDD2092  [3]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C365(1.31)  LDD2094  [3]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C365(0.82)  LDD2097  [3]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C365(1.00)  LDD2098  [3]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C365(0.58); C269(0.52)  LDD2100  [3]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C365(0.64)  LDD2101  [3]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C365(0.73); C269(1.08)  LDD2104  [3]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C365(1.38)  LDD2105  [3]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C365(0.45); C269(0.53)  LDD2106  [3]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C365(0.51); C269(0.77)  LDD2108  [3]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C269(0.54)  LDD2110  [3]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C365(0.89); C269(0.74)  LDD2114  [3]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C365(0.56)  LDD2115  [3]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C365(0.48)  LDD2124  [3]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C365(0.53)  LDD2126  [3]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C365(0.60)  LDD2133  [3]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C365(0.57); C269(0.80)  LDD2141  [3]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C365(1.00); C269(1.83)  LDD2145  [3]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C365(0.52)  LDD2148  [3]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C365(0.39)  LDD2150  [3]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C365(1.69)  LDD2153  [3]
 LDCM0016  Ranjitkar_cp1 MDA-MB-231 2.08  LDD0123  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Propionyl-CoA carboxylase alpha chain, mitochondrial (PCCA) . P05165
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Alpha-actinin-3 (ACTN3) Alpha-actinin family Q08043

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Biotin Small molecular drug DB00121
Valine Small molecular drug DB00161

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 Total Synthesis and Target Identification of the Curcusone Diterpenes. J Am Chem Soc. 2021 Mar 24;143(11):4379-4386. doi: 10.1021/jacs.1c00557. Epub 2021 Mar 11.
6 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
7 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
12 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
13 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
14 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
15 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
16 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
17 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
18 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402