Details of the Target

General Information of Target

Target ID LDTP07573
Target Name Proline/serine-rich coiled-coil protein 1 (PSRC1)
Gene Name PSRC1
Gene ID 84722
Synonyms
DDA3; Proline/serine-rich coiled-coil protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEDLEEDVRFIVDETLDFGGLSPSDSREEEDITVLVTPEKPLRRGLSHRSDPNAVAPAPQ
GVRLSLGPLSPEKLEEILDEANRLAAQLEQCALQDRESAGEGLGPRRVKPSPRRETFVLK
DSPVRDLLPTVNSLTRSTPSPSSLTPRLRSNDRKGSVRALRATSGKRPSNMKRESPTCNL
FPASKSPASSPLTRSTPPVRGRAGPSGRAAASEETRAAKLRVSGSGEFVGLTLKFLHPSP
PGPPTPIRSVLAPQPSTSNSQRLPRPQGAAAKSSSQLPIPSAIPRPASRMPLTSRSVPPG
RGALPPDSLSTRKGLPRPSTAGHRVRESGHKVPVSQRLNLPVMGATRSNLQPPRKVAVPG
PTR
Target Bioclass
Other
Family
PSRC1 family
Subcellular location
Cytoplasm
Function
Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A and ANKRD53 to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression.
Uniprot ID
Q6PGN9
Ensemble ID
ENST00000369903.6
HGNC ID
HGNC:24472

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Curcusone 37
 Probe Info  		3.31  LDD0188  [1]
IA-alkyne
 Probe Info  		C91(4.39)  LDD0371  [2]
DBIA
 Probe Info  		C91(1.68)  LDD0080  [3]
IPM
 Probe Info  		N.A.  LDD0025  [4]
NAIA_5
 Probe Info  		N.A.  LDD2225  [5]
TFBX
 Probe Info  		N.A.  LDD0027  [4]
VSF
 Probe Info  		N.A.  LDD0007  [6]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [7]
Methacrolein
 Probe Info  		N.A.  LDD0218  [8]
W1
 Probe Info  		N.A.  LDD0236  [9]
AOyne
 Probe Info  		13.80  LDD0443  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C91(4.39)  LDD0371  [2]
 LDCM0026  4SU-RNA+native RNA HEK-293T C91(4.75)  LDD0372  [2]
 LDCM0215  AC10 HEK-293T C178(1.11)  LDD1508  [11]
 LDCM0277  AC18 HEK-293T C178(1.14)  LDD1516  [11]
 LDCM0279  AC2 HEK-293T C178(1.16)  LDD1518  [11]
 LDCM0284  AC24 HEK-293T C178(1.03)  LDD1523  [11]
 LDCM0286  AC26 HEK-293T C178(1.18)  LDD1525  [11]
 LDCM0293  AC32 HEK-293T C178(1.02)  LDD1532  [11]
 LDCM0295  AC34 HEK-293T C178(1.20)  LDD1534  [11]
 LDCM0302  AC40 HEK-293T C178(1.03)  LDD1541  [11]
 LDCM0304  AC42 HEK-293T C178(1.08)  LDD1543  [11]
 LDCM0310  AC48 HEK-293T C178(1.02)  LDD1549  [11]
 LDCM0313  AC50 HEK-293T C178(1.07)  LDD1552  [11]
 LDCM0319  AC56 HEK-293T C178(1.07)  LDD1558  [11]
 LDCM0321  AC58 HEK-293T C178(1.18)  LDD1560  [11]
 LDCM0328  AC64 HEK-293T C178(0.98)  LDD1567  [11]
 LDCM0345  AC8 HEK-293T C178(1.04)  LDD1569  [11]
 LDCM0275  AKOS034007705 HEK-293T C178(1.01)  LDD1514  [11]
 LDCM0367  CL1 HEK-293T C178(1.32)  LDD1571  [11]
 LDCM0369  CL100 HEK-293T C178(1.04)  LDD1573  [11]
 LDCM0370  CL101 HEK-293T C178(1.15)  LDD1574  [11]
 LDCM0372  CL103 HEK-293T C178(1.34)  LDD1576  [11]
 LDCM0373  CL104 HEK-293T C178(1.06)  LDD1577  [11]
 LDCM0374  CL105 HEK-293T C178(1.32)  LDD1578  [11]
 LDCM0376  CL107 HEK-293T C178(1.13)  LDD1580  [11]
 LDCM0377  CL108 HEK-293T C178(1.11)  LDD1581  [11]
 LDCM0378  CL109 HEK-293T C178(1.03)  LDD1582  [11]
 LDCM0381  CL111 HEK-293T C178(1.12)  LDD1585  [11]
 LDCM0382  CL112 HEK-293T C178(1.07)  LDD1586  [11]
 LDCM0383  CL113 HEK-293T C178(1.17)  LDD1587  [11]
 LDCM0385  CL115 HEK-293T C178(1.15)  LDD1589  [11]
 LDCM0386  CL116 HEK-293T C178(1.06)  LDD1590  [11]
 LDCM0387  CL117 HEK-293T C178(1.15)  LDD1591  [11]
 LDCM0389  CL119 HEK-293T C178(1.03)  LDD1593  [11]
 LDCM0390  CL12 HEK-293T C178(0.88)  LDD1594  [11]
 LDCM0391  CL120 HEK-293T C178(1.06)  LDD1595  [11]
 LDCM0392  CL121 HEK-293T C178(1.07)  LDD1596  [11]
 LDCM0394  CL123 HEK-293T C178(0.94)  LDD1598  [11]
 LDCM0395  CL124 HEK-293T C178(1.04)  LDD1599  [11]
 LDCM0396  CL125 HEK-293T C178(1.11)  LDD1600  [11]
 LDCM0398  CL127 HEK-293T C178(1.18)  LDD1602  [11]
 LDCM0399  CL128 HEK-293T C178(1.03)  LDD1603  [11]
 LDCM0400  CL13 HEK-293T C178(1.22)  LDD1604  [11]
 LDCM0402  CL15 HEK-293T C178(1.07)  LDD1606  [11]
 LDCM0403  CL16 HEK-293T C178(1.03)  LDD1607  [11]
 LDCM0405  CL18 HEK-293T C178(1.06)  LDD1609  [11]
 LDCM0412  CL24 HEK-293T C178(0.88)  LDD1616  [11]
 LDCM0413  CL25 HEK-293T C178(1.07)  LDD1617  [11]
 LDCM0415  CL27 HEK-293T C178(1.04)  LDD1619  [11]
 LDCM0416  CL28 HEK-293T C178(0.98)  LDD1620  [11]
 LDCM0418  CL3 HEK-293T C178(1.27)  LDD1622  [11]
 LDCM0419  CL30 HEK-293T C178(1.16)  LDD1623  [11]
 LDCM0425  CL36 HEK-293T C178(0.87)  LDD1629  [11]
 LDCM0426  CL37 HEK-293T C178(1.13)  LDD1630  [11]
 LDCM0428  CL39 HEK-293T C178(1.05)  LDD1632  [11]
 LDCM0429  CL4 HEK-293T C178(0.99)  LDD1633  [11]
 LDCM0430  CL40 HEK-293T C178(1.07)  LDD1634  [11]
 LDCM0432  CL42 HEK-293T C178(1.05)  LDD1636  [11]
 LDCM0438  CL48 HEK-293T C178(0.71)  LDD1642  [11]
 LDCM0439  CL49 HEK-293T C178(1.03)  LDD1643  [11]
 LDCM0443  CL52 HEK-293T C178(1.07)  LDD1646  [11]
 LDCM0445  CL54 HEK-293T C178(1.06)  LDD1648  [11]
 LDCM0451  CL6 HEK-293T C178(1.13)  LDD1654  [11]
 LDCM0452  CL60 HEK-293T C178(0.81)  LDD1655  [11]
 LDCM0453  CL61 HEK-293T C178(1.02)  LDD1656  [11]
 LDCM0455  CL63 HEK-293T C178(1.15)  LDD1658  [11]
 LDCM0456  CL64 HEK-293T C178(1.11)  LDD1659  [11]
 LDCM0458  CL66 HEK-293T C178(0.93)  LDD1661  [11]
 LDCM0465  CL72 HEK-293T C178(0.93)  LDD1668  [11]
 LDCM0466  CL73 HEK-293T C178(1.14)  LDD1669  [11]
 LDCM0469  CL76 HEK-293T C178(1.16)  LDD1672  [11]
 LDCM0471  CL78 HEK-293T C178(1.21)  LDD1674  [11]
 LDCM0478  CL84 HEK-293T C178(0.90)  LDD1681  [11]
 LDCM0479  CL85 HEK-293T C178(1.17)  LDD1682  [11]
 LDCM0481  CL87 HEK-293T C178(1.06)  LDD1684  [11]
 LDCM0482  CL88 HEK-293T C178(1.14)  LDD1685  [11]
 LDCM0485  CL90 HEK-293T C178(1.04)  LDD1688  [11]
 LDCM0491  CL96 HEK-293T C178(0.88)  LDD1694  [11]
 LDCM0492  CL97 HEK-293T C178(1.21)  LDD1695  [11]
 LDCM0494  CL99 HEK-293T C178(1.09)  LDD1697  [11]
 LDCM0033  Curcusone1d MCF-7 3.31  LDD0188  [1]
 LDCM0495  E2913 HEK-293T C178(1.21)  LDD1698  [11]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C91(2.06)  LDD1702  [12]
 LDCM0468  Fragment33 HEK-293T C178(1.08)  LDD1671  [11]
 LDCM0022  KB02 HCT 116 C91(1.68)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C91(1.44)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C91(1.73)  LDD0082  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Microtubule-associated protein RP/EB family member 3 (MAPRE3) MAPRE family Q9UPY8

References

1 Total Synthesis and Target Identification of the Curcusone Diterpenes. J Am Chem Soc. 2021 Mar 24;143(11):4379-4386. doi: 10.1021/jacs.1c00557. Epub 2021 Mar 11.
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
8 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
9 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761