Details of the Target

General Information of Target

Target ID LDTP04683
Target Name Peregrin (BRPF1)
Gene Name BRPF1
Gene ID 7862
Synonyms
BR140; Peregrin; Bromodomain and PHD finger-containing protein 1; Protein Br140
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGVDFDVKTFCHNLRATKPPYECPVETCRKVYKSYSGIEYHLYHYDHDNPPPPQQTPLRK
HKKKGRQSRPANKQSPSPSEVSQSPGREVMSYAQAQRMVEVDLHGRVHRISIFDNLDVVS
EDEEAPEEAPENGSNKENTETPAATPKSGKHKNKEKRKDSNHHHHHNVSASTTPKLPEVV
YRELEQDTPDAPPRPTSYYRYIEKSAEELDEEVEYDMDEEDYIWLDIMNERRKTEGVSPI
PQEIFEYLMDRLEKESYFESHNKGDPNALVDEDAVCCICNDGECQNSNVILFCDMCNLAV
HQECYGVPYIPEGQWLCRRCLQSPSRAVDCALCPNKGGAFKQTDDGRWAHVVCALWIPEV
CFANTVFLEPIDSIEHIPPARWKLTCYICKQRGSGACIQCHKANCYTAFHVTCAQQAGLY
MKMEPVRETGANGTSFSVRKTAYCDIHTPPGSARRLPALSHSEGEEDEDEEEDEGKGWSS
EKVKKAKAKSRIKMKKARKILAEKRAAAPVVSVPCIPPHRLSKITNRLTIQRKSQFMQRL
HSYWTLKRQSRNGVPLLRRLQTHLQSQRNCDQVGRDSEDKNWALKEQLKSWQRLRHDLER
ARLLVELIRKREKLKRETIKVQQIAMEMQLTPFLILLRKTLEQLQEKDTGNIFSEPVPLS
EVPDYLDHIKKPMDFFTMKQNLEAYRYLNFDDFEEDFNLIVSNCLKYNAKDTIFYRAAVR
LREQGGAVLRQARRQAEKMGIDFETGMHIPHSLAGDEATHHTEDAAEEERLVLLENQKHL
PVEEQLKLLLERLDEVNASKQSVGRSRRAKMIKKEMTALRRKLAHQRETGRDGPERHGPS
SRGSLTPHPAACDKDGQTDSAAEESSSQETSKGLGPNMSSTPAHEVGRRTSVLFSKKNPK
TAGPPKRPGRPPKNRESQMTPSHGGSPVGPPQLPIMSSLRQRKRGRSPRPSSSSDSDSDK
STEDPPMDLPANGFSGGNQPVKKSFLVYRNDCSLPRSSSDSESSSSSSSSAASDRTSTTP
SKQGRGKPSFSRGTFPEDSSEDTSGTENEAYSVGTGRGVGHSMVRKSLGRGAGWLSEDED
SPLDALDLVWAKCRGYPSYPALIIDPKMPREGMFHHGVPIPVPPLEVLKLGEQMTQEARE
HLYLVLFFDNKRTWQWLPRTKLVPLGVNQDLDKEKMLEGRKSNIRKSVQIAYHRALQHRS
KVQGEQSSETSDSD
Target Type
Literature-reported
Target Bioclass
Transcription factor
Subcellular location
Nucleus
Function
Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, which have a histone H3 acetyltransferase activity. Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac). Some HAT complexes preferentially mediate histone H3 'Lys-23' (H3K23ac) acetylation. Positively regulates the transcription of RUNX1 and RUNX2.
TTD ID
T41145
Uniprot ID
P55201
DrugMap ID
TTT46BN
Ensemble ID
ENST00000383829.7
HGNC ID
HGNC:14255
ChEMBL ID
CHEMBL3132741

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C570(2.96); C11(1.62)  LDD3310  [1]
AHL-Pu-1
 Probe Info  		C852(2.61)  LDD0169  [2]
Acrolein
 Probe Info  		N.A.  LDD0222  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [4]
IPM
 Probe Info  		N.A.  LDD0005  [5]
TFBX
 Probe Info  		N.A.  LDD0148  [6]
VSF
 Probe Info  		N.A.  LDD0007  [5]
Phosphinate-6
 Probe Info  		C852(0.00); C992(0.00)  LDD0018  [7]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C153
 Probe Info  		16.56  LDD1834  [8]
C293
 Probe Info  		18.64  LDD1963  [8]
photo_BS
 Probe Info  		1.60  LDD0414  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C852(2.61)  LDD0169  [2]
 LDCM0214  AC1 HEK-293T C852(0.99); C992(1.05); C570(0.95)  LDD1507  [10]
 LDCM0215  AC10 HEK-293T C852(1.01); C397(1.14)  LDD1508  [10]
 LDCM0226  AC11 HEK-293T C852(0.95); C992(1.08); C11(1.03)  LDD1509  [10]
 LDCM0237  AC12 HEK-293T C852(1.05); C515(1.27); C992(1.17); C570(1.11)  LDD1510  [10]
 LDCM0259  AC14 HEK-293T C852(1.01); C992(1.11)  LDD1512  [10]
 LDCM0270  AC15 HEK-293T C852(1.04); C515(0.94); C992(1.10); C320(1.05)  LDD1513  [10]
 LDCM0276  AC17 HEK-293T C852(0.97); C992(1.12); C570(1.05)  LDD1515  [10]
 LDCM0277  AC18 HEK-293T C852(0.86); C397(1.07)  LDD1516  [10]
 LDCM0278  AC19 HEK-293T C852(1.07); C992(1.40); C11(1.06)  LDD1517  [10]
 LDCM0279  AC2 HEK-293T C852(1.00); C397(0.81)  LDD1518  [10]
 LDCM0280  AC20 HEK-293T C852(0.99); C515(0.92); C992(1.09); C570(1.03)  LDD1519  [10]
 LDCM0281  AC21 HEK-293T C852(0.84); C992(1.02); C570(1.26)  LDD1520  [10]
 LDCM0282  AC22 HEK-293T C852(1.11); C992(1.06)  LDD1521  [10]
 LDCM0283  AC23 HEK-293T C852(1.00); C515(0.89); C992(1.09); C320(1.05)  LDD1522  [10]
 LDCM0284  AC24 HEK-293T C852(1.06); C11(1.10); C570(0.96); C320(1.02)  LDD1523  [10]
 LDCM0285  AC25 HEK-293T C852(1.10); C992(1.05); C570(1.07)  LDD1524  [10]
 LDCM0286  AC26 HEK-293T C852(1.03); C397(0.88)  LDD1525  [10]
 LDCM0287  AC27 HEK-293T C852(1.12); C992(1.08); C11(0.96)  LDD1526  [10]
 LDCM0288  AC28 HEK-293T C852(1.09); C515(1.09); C992(1.08); C570(1.09)  LDD1527  [10]
 LDCM0289  AC29 HEK-293T C852(1.02); C992(1.03); C570(1.12)  LDD1528  [10]
 LDCM0290  AC3 HEK-293T C852(1.07); C992(0.96); C11(0.96)  LDD1529  [10]
 LDCM0291  AC30 HEK-293T C852(0.96); C992(1.14)  LDD1530  [10]
 LDCM0292  AC31 HEK-293T C852(0.96); C515(1.00); C992(1.06); C320(0.92)  LDD1531  [10]
 LDCM0293  AC32 HEK-293T C852(1.10); C11(0.99); C570(1.05); C320(1.11)  LDD1532  [10]
 LDCM0294  AC33 HEK-293T C852(0.89); C992(0.94); C570(1.01)  LDD1533  [10]
 LDCM0295  AC34 HEK-293T C852(0.88); C397(1.13)  LDD1534  [10]
 LDCM0296  AC35 HEK-293T C852(0.99); C992(1.14); C11(0.96)  LDD1535  [10]
 LDCM0297  AC36 HEK-293T C852(1.05); C515(1.02); C992(1.05); C570(1.22)  LDD1536  [10]
 LDCM0298  AC37 HEK-293T C852(0.90); C992(1.01); C570(0.81)  LDD1537  [10]
 LDCM0299  AC38 HEK-293T C852(0.85); C992(1.04)  LDD1538  [10]
 LDCM0300  AC39 HEK-293T C852(0.98); C515(1.16); C992(1.04); C320(1.02)  LDD1539  [10]
 LDCM0301  AC4 HEK-293T C852(1.18); C515(1.06); C992(0.95); C570(1.08)  LDD1540  [10]
 LDCM0302  AC40 HEK-293T C852(0.99); C11(1.02); C570(1.12); C320(0.99)  LDD1541  [10]
 LDCM0303  AC41 HEK-293T C852(0.83); C992(1.08); C570(1.01)  LDD1542  [10]
 LDCM0304  AC42 HEK-293T C852(0.85); C397(0.89)  LDD1543  [10]
 LDCM0305  AC43 HEK-293T C852(1.05); C992(1.12); C11(0.99)  LDD1544  [10]
 LDCM0306  AC44 HEK-293T C852(0.96); C515(1.66); C992(1.02); C570(1.04)  LDD1545  [10]
 LDCM0307  AC45 HEK-293T C852(1.03); C992(1.10); C570(0.95)  LDD1546  [10]
 LDCM0308  AC46 HEK-293T C852(0.86); C992(1.10)  LDD1547  [10]
 LDCM0309  AC47 HEK-293T C852(0.91); C515(1.08); C992(1.10); C320(1.07)  LDD1548  [10]
 LDCM0310  AC48 HEK-293T C852(1.07); C11(1.00); C570(1.07); C320(1.00)  LDD1549  [10]
 LDCM0311  AC49 HEK-293T C852(0.89); C992(1.03); C570(1.04)  LDD1550  [10]
 LDCM0312  AC5 HEK-293T C852(0.88); C992(0.98); C570(1.09)  LDD1551  [10]
 LDCM0313  AC50 HEK-293T C852(0.88); C397(0.95)  LDD1552  [10]
 LDCM0314  AC51 HEK-293T C852(1.09); C992(1.04); C11(1.01)  LDD1553  [10]
 LDCM0315  AC52 HEK-293T C852(0.98); C515(1.49); C992(1.20); C570(1.12)  LDD1554  [10]
 LDCM0316  AC53 HEK-293T C852(0.96); C992(0.99); C570(1.26)  LDD1555  [10]
 LDCM0317  AC54 HEK-293T C852(0.81); C992(1.14)  LDD1556  [10]
 LDCM0318  AC55 HEK-293T C852(0.87); C515(1.07); C992(1.04); C320(1.00)  LDD1557  [10]
 LDCM0319  AC56 HEK-293T C852(1.11); C11(1.00); C570(1.15); C320(1.15)  LDD1558  [10]
 LDCM0320  AC57 HEK-293T C852(0.80); C992(1.17); C570(1.02)  LDD1559  [10]
 LDCM0321  AC58 HEK-293T C852(0.81); C397(0.98)  LDD1560  [10]
 LDCM0322  AC59 HEK-293T C852(0.89); C992(1.00); C11(1.08)  LDD1561  [10]
 LDCM0323  AC6 HEK-293T C852(1.06); C992(1.06)  LDD1562  [10]
 LDCM0324  AC60 HEK-293T C852(1.07); C515(1.31); C992(0.89); C570(1.09)  LDD1563  [10]
 LDCM0325  AC61 HEK-293T C852(0.74); C992(1.04); C570(0.77)  LDD1564  [10]
 LDCM0326  AC62 HEK-293T C852(0.77); C992(1.09)  LDD1565  [10]
 LDCM0327  AC63 HEK-293T C852(0.99); C515(0.94); C992(1.01); C320(1.03)  LDD1566  [10]
 LDCM0328  AC64 HEK-293T C852(0.96); C11(0.99); C570(1.03); C320(1.14)  LDD1567  [10]
 LDCM0334  AC7 HEK-293T C852(0.93); C515(0.88); C992(0.98); C320(1.02)  LDD1568  [10]
 LDCM0345  AC8 HEK-293T C852(1.10); C11(1.05); C570(1.05); C320(1.12)  LDD1569  [10]
 LDCM0248  AKOS034007472 HEK-293T C852(0.95); C992(1.05); C570(1.07)  LDD1511  [10]
 LDCM0356  AKOS034007680 HEK-293T C852(0.99); C992(1.01); C570(1.07)  LDD1570  [10]
 LDCM0275  AKOS034007705 HEK-293T C852(0.97); C11(1.13); C570(1.10); C320(1.11)  LDD1514  [10]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [3]
 LDCM0367  CL1 HEK-293T C852(0.84)  LDD1571  [10]
 LDCM0368  CL10 HEK-293T C852(0.91); C992(1.07)  LDD1572  [10]
 LDCM0369  CL100 HEK-293T C852(0.98)  LDD1573  [10]
 LDCM0370  CL101 HEK-293T C852(1.05)  LDD1574  [10]
 LDCM0371  CL102 HEK-293T C852(0.90); C992(1.03)  LDD1575  [10]
 LDCM0373  CL104 HEK-293T C852(0.96)  LDD1577  [10]
 LDCM0374  CL105 HEK-293T C852(1.04)  LDD1578  [10]
 LDCM0375  CL106 HEK-293T C852(1.04); C992(1.14)  LDD1579  [10]
 LDCM0377  CL108 HEK-293T C852(0.90)  LDD1581  [10]
 LDCM0378  CL109 HEK-293T C852(0.88)  LDD1582  [10]
 LDCM0379  CL11 HEK-293T C852(1.03); C515(1.04); C992(1.05); C320(0.94)  LDD1583  [10]
 LDCM0380  CL110 HEK-293T C852(1.12); C992(0.98)  LDD1584  [10]
 LDCM0382  CL112 HEK-293T C852(0.89)  LDD1586  [10]
 LDCM0383  CL113 HEK-293T C852(0.99)  LDD1587  [10]
 LDCM0384  CL114 HEK-293T C852(1.02); C992(0.92)  LDD1588  [10]
 LDCM0386  CL116 HEK-293T C852(0.91)  LDD1590  [10]
 LDCM0387  CL117 HEK-293T C852(0.88)  LDD1591  [10]
 LDCM0388  CL118 HEK-293T C852(1.16); C992(1.08)  LDD1592  [10]
 LDCM0390  CL12 HEK-293T C852(1.10); C11(1.06); C570(0.87); C320(0.81)  LDD1594  [10]
 LDCM0391  CL120 HEK-293T C852(1.13)  LDD1595  [10]
 LDCM0392  CL121 HEK-293T C852(0.91)  LDD1596  [10]
 LDCM0393  CL122 HEK-293T C852(0.94); C992(1.12)  LDD1597  [10]
 LDCM0395  CL124 HEK-293T C852(0.63)  LDD1599  [10]
 LDCM0396  CL125 HEK-293T C852(0.71)  LDD1600  [10]
 LDCM0397  CL126 HEK-293T C852(0.82); C992(0.94)  LDD1601  [10]
 LDCM0399  CL128 HEK-293T C852(0.69)  LDD1603  [10]
 LDCM0400  CL13 HEK-293T C852(1.12)  LDD1604  [10]
 LDCM0401  CL14 HEK-293T C852(1.10); C992(1.01)  LDD1605  [10]
 LDCM0403  CL16 HEK-293T C852(0.80)  LDD1607  [10]
 LDCM0404  CL17 HEK-293T C852(0.81); C992(1.01); C570(0.97)  LDD1608  [10]
 LDCM0405  CL18 HEK-293T C852(0.86); C397(1.03)  LDD1609  [10]
 LDCM0406  CL19 HEK-293T C852(0.93); C992(1.19); C11(1.11)  LDD1610  [10]
 LDCM0407  CL2 HEK-293T C852(0.91); C992(1.07)  LDD1611  [10]
 LDCM0408  CL20 HEK-293T C852(1.06); C515(1.42); C992(1.15); C570(1.08)  LDD1612  [10]
 LDCM0409  CL21 HEK-293T C852(0.89); C992(1.01); C570(2.63)  LDD1613  [10]
 LDCM0410  CL22 HEK-293T C852(0.95); C992(1.18)  LDD1614  [10]
 LDCM0411  CL23 HEK-293T C852(1.02); C515(1.13); C992(1.07); C320(1.07)  LDD1615  [10]
 LDCM0412  CL24 HEK-293T C852(1.10); C11(1.05); C570(0.99); C320(1.38)  LDD1616  [10]
 LDCM0413  CL25 HEK-293T C852(0.90)  LDD1617  [10]
 LDCM0414  CL26 HEK-293T C852(0.99); C992(1.13)  LDD1618  [10]
 LDCM0416  CL28 HEK-293T C852(1.00)  LDD1620  [10]
 LDCM0417  CL29 HEK-293T C852(0.94); C992(0.99); C570(1.03)  LDD1621  [10]
 LDCM0419  CL30 HEK-293T C852(0.91); C397(0.95)  LDD1623  [10]
 LDCM0420  CL31 HEK-293T C852(1.02); C992(1.18); C11(1.25)  LDD1624  [10]
 LDCM0421  CL32 HEK-293T C852(1.10); C515(2.45); C992(1.10); C570(1.08)  LDD1625  [10]
 LDCM0422  CL33 HEK-293T C852(0.82); C992(1.13); C570(3.39)  LDD1626  [10]
 LDCM0423  CL34 HEK-293T C852(1.08); C992(1.13)  LDD1627  [10]
 LDCM0424  CL35 HEK-293T C852(0.97); C515(1.04); C992(1.10); C320(0.89)  LDD1628  [10]
 LDCM0425  CL36 HEK-293T C852(1.04); C11(1.10); C570(1.03); C320(1.06)  LDD1629  [10]
 LDCM0426  CL37 HEK-293T C852(0.94)  LDD1630  [10]
 LDCM0429  CL4 HEK-293T C852(0.70)  LDD1633  [10]
 LDCM0430  CL40 HEK-293T C852(0.99)  LDD1634  [10]
 LDCM0431  CL41 HEK-293T C852(1.09); C992(1.05); C570(0.94)  LDD1635  [10]
 LDCM0432  CL42 HEK-293T C852(0.87); C397(0.92)  LDD1636  [10]
 LDCM0433  CL43 HEK-293T C852(1.12); C992(0.98); C11(1.12)  LDD1637  [10]
 LDCM0434  CL44 HEK-293T C852(1.20); C515(1.33); C992(0.97); C570(0.93)  LDD1638  [10]
 LDCM0435  CL45 HEK-293T C852(0.96); C992(1.11); C570(1.94)  LDD1639  [10]
 LDCM0436  CL46 HEK-293T C852(1.07); C992(1.17)  LDD1640  [10]
 LDCM0437  CL47 HEK-293T C852(1.08); C515(0.94); C992(1.07); C320(1.03)  LDD1641  [10]
 LDCM0438  CL48 HEK-293T C852(1.00); C11(1.10); C570(1.03); C320(0.97)  LDD1642  [10]
 LDCM0439  CL49 HEK-293T C852(0.74)  LDD1643  [10]
 LDCM0440  CL5 HEK-293T C852(0.69); C992(0.97); C570(0.93)  LDD1644  [10]
 LDCM0441  CL50 HEK-293T C852(1.05); C992(0.99)  LDD1645  [10]
 LDCM0443  CL52 HEK-293T C852(0.88)  LDD1646  [10]
 LDCM0444  CL53 HEK-293T C852(0.99); C992(1.04); C570(0.98)  LDD1647  [10]
 LDCM0445  CL54 HEK-293T C852(0.76); C397(1.02)  LDD1648  [10]
 LDCM0446  CL55 HEK-293T C852(1.08); C992(1.04); C11(1.01)  LDD1649  [10]
 LDCM0447  CL56 HEK-293T C852(1.03); C515(0.87); C992(1.09); C570(1.22)  LDD1650  [10]
 LDCM0448  CL57 HEK-293T C852(0.83); C992(1.11); C570(1.89)  LDD1651  [10]
 LDCM0449  CL58 HEK-293T C852(0.85); C992(1.25)  LDD1652  [10]
 LDCM0450  CL59 HEK-293T C852(1.03); C515(1.07); C992(1.07); C320(1.08)  LDD1653  [10]
 LDCM0451  CL6 HEK-293T C852(0.79); C397(0.90)  LDD1654  [10]
 LDCM0452  CL60 HEK-293T C852(1.01); C11(1.20); C570(1.02); C320(0.95)  LDD1655  [10]
 LDCM0453  CL61 HEK-293T C852(0.92)  LDD1656  [10]
 LDCM0454  CL62 HEK-293T C852(0.98); C992(1.18)  LDD1657  [10]
 LDCM0456  CL64 HEK-293T C852(0.86)  LDD1659  [10]
 LDCM0457  CL65 HEK-293T C852(1.00); C992(0.91); C570(1.17)  LDD1660  [10]
 LDCM0458  CL66 HEK-293T C852(0.88); C397(0.92)  LDD1661  [10]
 LDCM0459  CL67 HEK-293T C852(1.03); C992(1.08); C11(1.13)  LDD1662  [10]
 LDCM0460  CL68 HEK-293T C852(0.89); C515(1.08); C992(0.97); C570(1.00)  LDD1663  [10]
 LDCM0461  CL69 HEK-293T C852(0.68); C992(1.08); C570(2.00)  LDD1664  [10]
 LDCM0462  CL7 HEK-293T C852(0.91); C992(0.96); C11(1.06)  LDD1665  [10]
 LDCM0463  CL70 HEK-293T C852(0.94); C992(1.14)  LDD1666  [10]
 LDCM0464  CL71 HEK-293T C852(0.92); C515(1.05); C992(1.19); C320(1.01)  LDD1667  [10]
 LDCM0465  CL72 HEK-293T C852(1.06); C11(1.14); C570(1.11); C320(1.03)  LDD1668  [10]
 LDCM0466  CL73 HEK-293T C852(0.89)  LDD1669  [10]
 LDCM0467  CL74 HEK-293T C852(0.93); C992(1.03)  LDD1670  [10]
 LDCM0469  CL76 HEK-293T C852(0.88)  LDD1672  [10]
 LDCM0470  CL77 HEK-293T C852(0.73); C992(0.96); C570(1.08)  LDD1673  [10]
 LDCM0471  CL78 HEK-293T C852(0.86); C397(1.01)  LDD1674  [10]
 LDCM0472  CL79 HEK-293T C852(0.92); C992(1.06); C11(1.08)  LDD1675  [10]
 LDCM0473  CL8 HEK-293T C852(0.70); C515(0.75); C992(0.89); C570(0.89)  LDD1676  [10]
 LDCM0474  CL80 HEK-293T C852(1.06); C515(1.08); C992(1.04); C570(1.27)  LDD1677  [10]
 LDCM0475  CL81 HEK-293T C852(0.78); C992(1.12); C570(1.27)  LDD1678  [10]
 LDCM0476  CL82 HEK-293T C852(0.92); C992(1.13)  LDD1679  [10]
 LDCM0477  CL83 HEK-293T C852(0.94); C515(1.28); C992(1.11); C320(1.10)  LDD1680  [10]
 LDCM0478  CL84 HEK-293T C852(0.99); C11(1.03); C570(0.99); C320(0.86)  LDD1681  [10]
 LDCM0479  CL85 HEK-293T C852(0.79)  LDD1682  [10]
 LDCM0480  CL86 HEK-293T C852(0.76); C992(0.89)  LDD1683  [10]
 LDCM0482  CL88 HEK-293T C852(0.80)  LDD1685  [10]
 LDCM0483  CL89 HEK-293T C852(0.63); C992(0.99); C570(0.96)  LDD1686  [10]
 LDCM0484  CL9 HEK-293T C852(0.77); C992(1.01); C570(1.40)  LDD1687  [10]
 LDCM0485  CL90 HEK-293T C852(0.58); C397(1.04)  LDD1688  [10]
 LDCM0486  CL91 HEK-293T C852(0.76); C992(1.03); C11(1.07)  LDD1689  [10]
 LDCM0487  CL92 HEK-293T C852(0.86); C515(1.18); C992(1.02); C570(0.96)  LDD1690  [10]
 LDCM0488  CL93 HEK-293T C852(0.76); C992(1.05); C570(1.73)  LDD1691  [10]
 LDCM0489  CL94 HEK-293T C852(0.78); C992(1.11)  LDD1692  [10]
 LDCM0490  CL95 HEK-293T C852(0.76); C515(0.91); C992(1.18); C320(0.84)  LDD1693  [10]
 LDCM0491  CL96 HEK-293T C852(0.73); C11(0.94); C570(0.87); C320(0.94)  LDD1694  [10]
 LDCM0492  CL97 HEK-293T C852(0.86)  LDD1695  [10]
 LDCM0493  CL98 HEK-293T C852(0.97); C992(1.03)  LDD1696  [10]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C852(1.27)  LDD1702  [11]
 LDCM0427  Fragment51 HEK-293T C852(1.02); C992(1.04)  LDD1631  [10]
 LDCM0161  GSK6853 HEK-293T 1.60  LDD0414  [9]
 LDCM0022  KB02 HEK-293T C570(1.03); C11(1.00); C992(0.87); C515(0.85)  LDD1492  [10]
 LDCM0023  KB03 HEK-293T C570(1.23); C11(1.04); C992(0.97); C515(0.95)  LDD1497  [10]
 LDCM0024  KB05 COLO792 C570(2.96); C11(1.62)  LDD3310  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
N-terminal EF-hand calcium-binding protein 1 (NECAB1) . Q8N987
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone H2A type 1 (H2AC11; H2AC13; H2AC15; H2AC16; H2AC17) Histone H2A family P0C0S8
Histone H4 (H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16) Histone H4 family P62805
Inhibitor of growth protein 5 (ING5) ING family Q8WYH8
Harmonin-binding protein USHBP1 (USHBP1) MCC family Q8N6Y0
Cell division cycle-associated 7-like protein (CDCA7L) . Q96GN5
Centrosomal protein of 70 kDa (CEP70) . Q8NHQ1
Protein moonraker (KIAA0753) . Q2KHM9

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 7 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ni-57 Small molecular drug D0O6XT
Of-1 Small molecular drug D08RDI
Pfi-4 Small molecular drug D0Q7IU
Pmid25408830c1 Small molecular drug D09ZPM
Pmid25408830c2 Small molecular drug D0J6XI
Pmid25408830c3 Small molecular drug D03BTJ
Pmid25974391c34 Small molecular drug D0C2PD

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
8 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
9 Chemical Proteomic Profiling of Bromodomains Enables the Wide-Spectrum Evaluation of Bromodomain Inhibitors in Living Cells. J Am Chem Soc. 2019 Jul 24;141(29):11497-11505. doi: 10.1021/jacs.9b02738. Epub 2019 Jul 9.
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
11 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761