Details of the Target

General Information of Target

Target ID LDTP15741
Target Name Cytochrome c oxidase assembly protein COX14 (COX14)
Gene Name COX14
Gene ID 84987
Synonyms
C12orf62; Cytochrome c oxidase assembly protein COX14
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPEQSNDYRVAVFGAGGVGKSSLVLRFVKGTFRESYIPTVEDTYRQVISCDKSICTLQIT
DTTGSHQFPAMQRLSISKGHAFILVYSITSRQSLEELKPIYEQICEIKGDVESIPIMLVG
NKCDESPSREVQSSEAEALARTWKCAFMETSAKLNHNVKELFQELLNLEKRRTVSLQIDG
KKSKQQKRKEKLKGKCVIM
Target Bioclass
Other
Subcellular location
Mitochondrion membrane
Function
Core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. Requires for coordination of the early steps of cytochrome c oxidase assembly with the synthesis of MT-CO1.
Uniprot ID
Q96I36
Ensemble ID
ENST00000317943.6
HGNC ID
HGNC:28216

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TFBX
 Probe Info  		N.A.  LDD0027  [1]
PAL-AfBPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C055
 Probe Info  		14.83  LDD1752  [2]
C056
 Probe Info  		25.11  LDD1753  [2]
C106
 Probe Info  		16.45  LDD1793  [2]
C112
 Probe Info  		24.08  LDD1799  [2]
C252
 Probe Info  		11.31  LDD1925  [2]
C278
 Probe Info  		77.71  LDD1948  [2]
C293
 Probe Info  		24.25  LDD1963  [2]
C388
 Probe Info  		83.29  LDD2047  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
LRP chaperone MESD (MESD) MESD family Q14696

References

1 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
2 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587