Details of the Target

General Information of Target

Target ID LDTP09278
Target Name Multiple coagulation factor deficiency protein 2 (MCFD2)
Gene Name MCFD2
Gene ID 90411
Synonyms
SDNSF; Multiple coagulation factor deficiency protein 2; Neural stem cell-derived neuronal survival protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTMRSLLRTPFLCGLLWAFCAPGARAEEPAASFSQPGSMGLDKNTVHDQEHIMEHLEGVI
NKPEAEMSPQELQLHYFKMHDYDGNNLLDGLELSTAITHVHKEEGSEQAPLMSEDELINI
IDGVLRDDDKNNDGYIDYAEFAKSLQ
Target Bioclass
Transporter and channel
Subcellular location
Endoplasmic reticulum-Golgi intermediate compartment
Function The MCFD2-LMAN1 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins. Plays a role in the secretion of coagulation factors.
Uniprot ID
Q8NI22
Ensemble ID
ENST00000319466.9
HGNC ID
HGNC:18451

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
MM1S SNV: p.H101P .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Jackson_1
 Probe Info  		12.53  LDD0121  [2]
PAL-AfBPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C017
 Probe Info  		14.83  LDD1725  [3]
C055
 Probe Info  		19.03  LDD1752  [3]
C056
 Probe Info  		33.59  LDD1753  [3]
C112
 Probe Info  		30.91  LDD1799  [3]
FFF probe11
 Probe Info  		20.00  LDD0472  [4]
FFF probe14
 Probe Info  		20.00  LDD0477  [4]
BD-F
 Probe Info  		S113(0.00); E104(0.00); E103(0.00); A109(0.00)  LDD0024  [5]
LD-F
 Probe Info  		D115(0.00); E104(0.00); A109(0.00)  LDD0015  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0071  Cisar_cp14 MDA-MB-231 12.53  LDD0121  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Inactive pancreatic lipase-related protein 1 (PNLIPRP1) Lipase family P54315
Stearoyl-CoA desaturase (SCD) Fatty acid desaturase type 1 family O00767
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Endophilin-B1 (SH3GLB1) Endophilin family Q9Y371
CMP-sialic acid transporter (SLC35A1) Nucleotide-sugar transporter family P78382
Protein ERGIC-53 (LMAN1) . P49257
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
P2Y purinoceptor 6 (P2RY6) G-protein coupled receptor 1 family Q15077
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cholecystokinin (CCK) Gastrin/cholecystokinin family P06307
Protein SYS1 homolog (SYS1) SYS1 family Q8N2H4

The Drug(s) Related To This Target

Approved
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Antihemophilic Factor Human Recombinant BiotechDrug DB00025
Lonoctocog Alfa . DB13998
Moroctocog Alfa . DB13999

References

1 Labeling Preferences of Diazirines with Protein Biomolecules. J Am Chem Soc. 2021 May 5;143(17):6691-6700. doi: 10.1021/jacs.1c02509. Epub 2021 Apr 20.
Mass spectrometry data entry: PXD025140
2 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
3 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
4 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
5 Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.
Mass spectrometry data entry: PXD025652