Details of the Target

General Information of Target

Target ID LDTP11438
Target Name Signal peptidase complex catalytic subunit SEC11C (SEC11C)
Gene Name SEC11C
Gene ID 90701
Synonyms
SEC11L3; SPC21; SPCS4C; Signal peptidase complex catalytic subunit SEC11C; EC 3.4.21.89; Microsomal signal peptidase 21 kDa subunit; SPase 21 kDa subunit; SEC11 homolog C; SEC11-like protein 3; SPC21
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASWAKGRSYLAPGLLQGQVAIVTGGATGIGKAIVKELLELGSNVVIASRKLERLKSAAD
ELQANLPPTKQARVIPIQCNIRNEEEVNNLVKSTLDTFGKINFLVNNGGGQFLSPAEHIS
SKGWHAVLETNLTGTFYMCKAVYSSWMKEHGGSIVNIIVPTKAGFPLAVHSGAARAGVYN
LTKSLALEWACSGIRINCVAPGVIYSQTAVENYGSWGQSFFEGSFQKIPAKRIGVPEEVS
SVVCFLLSPAASFITGQSVDVDGGRSLYTHSYEVPDHDNWPKGAGDLSVVKKMKETFKEK
AKL
Target Bioclass
Enzyme
Family
Peptidase S26B family
Subcellular location
Endoplasmic reticulum membrane
Function
Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids.
Uniprot ID
Q9BY50
Ensemble ID
ENST00000587834.6
HGNC ID
HGNC:23400

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K23(2.22)  LDD0277  [1]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C112
 Probe Info  		51.63  LDD1799  [2]
C186
 Probe Info  		8.28  LDD1864  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Stearoyl-CoA desaturase (SCD) Fatty acid desaturase type 1 family O00767
Heme oxygenase 1 (HMOX1) Heme oxygenase family P09601
Polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6 (PLPP6) PA-phosphatase related phosphoesterase family Q8IY26
Complement C2 (C2) Peptidase S1 family P06681
Serine protease 23 (PRSS23) Peptidase S1 family O95084
Signal peptidase complex subunit 3 (SPCS3) SPCS3 family P61009
Ubiquitin-conjugating enzyme E2 J1 (UBE2J1) Ubiquitin-conjugating enzyme family Q9Y385
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Vesicle-associated membrane protein-associated protein A (VAPA) VAMP-associated protein (VAP) (TC 9.B.17) family Q9P0L0
Immunoglobulin
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Butyrophilin subfamily 2 member A2 (BTN2A2) BTN/MOG family Q8WVV5
Cell adhesion molecule 3 (CADM3) Nectin family Q8N126
Other
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Stress-associated endoplasmic reticulum protein 1 (SERP1) RAMP4 family Q9Y6X1
Selenoprotein M (SELENOM) Selenoprotein M/F family Q8WWX9
Vesicle-associated membrane protein 4 (VAMP4) Synaptobrevin family O75379
Vesicle-associated membrane protein 5 (VAMP5) Synaptobrevin family O95183
Syntaxin-12 (STX12) Syntaxin family Q86Y82
Transmembrane protein 243 (TMEM243) TMEM243 family Q9BU79
Receptor-transporting protein 2 (RTP2) TMEM7 family Q5QGT7
Transmembrane protein 254 (TMEM254) . Q8TBM7
Transmembrane protein 42 (TMEM42) . Q69YG0

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587