Details of the Target

General Information of Target

Target ID LDTP05337
Target Name Dihydroorotate dehydrogenase (quinone), mitochondrial (DHODH)
Gene Name DHODH
Gene ID 1723
Synonyms
Dihydroorotate dehydrogenase; quinone), mitochondrial; DHOdehase; EC 1.3.5.2; Dihydroorotate oxidase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVR
FTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSV
TPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVN
LGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQER
DGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSET
GGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTF
WGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
Target Type
Successful
Target Bioclass
Enzyme
Family
Dihydroorotate dehydrogenase family, Type 2 subfamily
Subcellular location
Mitochondrion inner membrane
Function Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. Required for UMP biosynthesis via de novo pathway.
TTD ID
T61400
Uniprot ID
Q02127
DrugMap ID
TT3UY29
Ensemble ID
ENST00000219240.9
HGNC ID
HGNC:2867
ChEMBL ID
CHEMBL1966

Probe(s) Labeling This Target

PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C094
 Probe Info  		32.67  LDD1785  [1]
C112
 Probe Info  		17.03  LDD1799  [1]
C390
 Probe Info  		26.72  LDD2049  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 ubiquitin-protein ligase RNF19B (RNF19B) RBR family Q6ZMZ0
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Alpha-tocopherol transfer protein (TTPA) . P49638

The Drug(s) Related To This Target

Approved
Click To Hide/Show 4 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Atovaquone Small molecular drug DB01117
Leflunomide Small molecular drug DB01097
Teriflunomide Small molecular drug D07QFP
Flavin Mononucleotide . DB03247
Phase 2
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Brequinar Small molecular drug D0N3XT
Vidofludimus Small molecular drug D00LSI
Phase 1
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Bay2402234 . D08DMH
Las-186323 . D0F1JY
Investigative
Click To Hide/Show 22 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
(2z)-n-biphenyl-4-yl-2-cyano-3-hydroxybut-2-enamide Small molecular drug DB07443
3691215-pentaoxatricosan-1-ol Small molecular drug DB08249
Brequinar Small molecular drug DB03523
Capric Dimethyl Amine Oxide Small molecular drug DB02613
Dodecyldimethylamine N-oxide Small molecular drug DB04147
Orotic Acid Small molecular drug DB02262
Undecylamine-nn-dimethyl-n-oxide Small molecular drug DB07646
(2z)-2-cyano-n-(22'-dichlorobiphenyl-4-yl)-3-hydroxybut-2-enamide . DB07559
(2z)-2-cyano-n-(3'-ethoxybiphenyl-4-yl)-3-hydroxybut-2-enamide . DB07561
(2z)-n-(3-chloro-2'-methoxybiphenyl-4-yl)-2-cyano-3-hydroxybut-2-enamide . DB08172
(2z)-n-biphenyl-4-yl-2-cyano-3-cyclopropyl-3-hydroxyprop-2-enamide . DB08169
2-({[2356-tetrafluoro-3'-(Trifluoromethoxy)Biphenyl-4-yl]Amino}Carbonyl)Cyclopenta-13-diene-1-carboxylic Acid . DB07978
2-({[35-difluoro-3'-(Trifluoromethoxy)Biphenyl-4-yl]Amino}Carbonyl)Cyclopent-1-ene-1-carboxylic Acid . DB07975
2-[4-(4-chlorophenyl)Cyclohexylidene]-34-dihydroxy-1(2h)-naphthalenone . DB04281
3-({[35-difluoro-3'-(Trifluoromethoxy)Biphenyl-4-yl]Amino}Carbonyl)Thiophene-2-carboxylic Acid . DB07977
3-{[(3-fluoro-3'-methoxybiphenyl-4-yl)Amino]Carbonyl}Thiophene-2-carboxylic Acid . DB07976
5-carbamoyl-11':4'1''-terphenyl-3-carboxylic Acid . DB04583
5-methyl-n-[4-(Trifluoromethyl)Phenyl][124]Triazolo[15-a]Pyrimidin-7-amine . DB08008
Brequinar Analog . DB03480
Manitimus . DB06481
N-anthracen-2-yl-5-methyl[124]Triazolo[15-a]Pyrimidin-7-amine . DB08006
Sc12267 . DB05125
Discontinued
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Fk778 Small molecular drug D0X4IA
Hr325 Small molecular drug D0SX4K

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587