Details of the Target

General Information of Target

Target ID LDTP09788
Target Name Sorting nexin-19 (SNX19)
Gene Name SNX19
Gene ID 399979
Synonyms
KIAA0254; Sorting nexin-19
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MATAGGGSGADPGSRGLLRLLSFCVLLAGLCRGNSVERKIYIPLNKTAPCVRLLNATHQI
GCQSSISGDTGVIHVVEKEEDLQWVLTDGPNPPYMVLLESKHFTRDLMEKLKGRTSRIAG
LAVSLTKPSPASGFSPSVQCPNDGFGVYSNSYGPEFAHCREIQWNSLGNGLAYEDFSFPI
FLLEDENETKVIKQCYQDHNLSQNGSAPTFPLCAMQLFSHMHAVISTATCMRRSSIQSTF
SINPEIVCDPLSDYNVWSMLKPINTTGTLKPDDRVVVAATRLDSRSFFWNVAPGAESAVA
SFVTQLAAAEALQKAPDVTTLPRNVMFVFFQGETFDYIGSSRMVYDMEKGKFPVQLENVD
SFVELGQVALRTSLELWMHTDPVSQKNESVRNQVEDLLATLEKSGAGVPAVILRRPNQSQ
PLPPSSLQRFLRARNISGVVLADHSGAFHNKYYQSIYDTAENINVSYPEWLSPEEDLNFV
TDTAKALADVATVLGRALYELAGGTNFSDTVQADPQTVTRLLYGFLIKANNSWFQSILRQ
DLRSYLGDGPLQHYIAVSSPTNTTYVVQYALANLTGTVVNLTREQCQDPSKVPSENKDLY
EYSWVQGPLHSNETDRLPRCVRSTARLARALSPAFELSQWSSTEYSTWTESRWKDIRARI
FLIASKELELITLTVGFGILIFSLIVTYCINAKADVLFIAPREPGAVSY
Target Bioclass
Transporter and channel
Family
Sorting nexin family
Subcellular location
Early endosome membrane
Function
Plays a role in intracellular vesicle trafficking and exocytosis. May play a role in maintaining insulin-containing dense core vesicles in pancreatic beta-cells and in preventing their degradation. May play a role in insulin secretion. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)).
Uniprot ID
Q92543
Ensemble ID
ENST00000265909.9
HGNC ID
HGNC:21532

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
EFO21 SNV: p.T231I .
HT SNV: p.V239G .
HT115 SNV: p.L926F .
HUH1 SNV: p.E907Ter .
IGR37 SNV: p.E80Q .
IGR39 SNV: p.E80Q .
KYSE150 SNV: p.F893C .
MFE319 SNV: p.K454N .
NUGC3 Deletion: p.D786IfsTer35 .
OVK18 SNV: p.R119H .
RKO SNV: p.A821P .
SW403 SNV: p.V265M .
VMRCRCW SNV: p.L632F .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
CHEMBL5175495
 Probe Info  		7.27  LDD0196  [1]
ONAyne
 Probe Info  		K903(6.67)  LDD0275  [2]
AHL-Pu-1
 Probe Info  		C91(2.23)  LDD0168  [3]
IA-alkyne
 Probe Info  		C91(9.46)  LDD1703  [4]
DBIA
 Probe Info  		C476(1.19); C482(1.19)  LDD0078  [5]
NAIA_5
 Probe Info  		N.A.  LDD2225  [6]
IPM
 Probe Info  		N.A.  LDD2156  [7]
PAL-AfBPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C064
 Probe Info  		8.00  LDD1761  [8]
C091
 Probe Info  		23.59  LDD1782  [8]
C092
 Probe Info  		43.41  LDD1783  [8]
C094
 Probe Info  		41.07  LDD1785  [8]
C112
 Probe Info  		19.97  LDD1799  [8]
C134
 Probe Info  		28.64  LDD1816  [8]
C201
 Probe Info  		33.59  LDD1877  [8]
C206
 Probe Info  		16.00  LDD1881  [8]
C228
 Probe Info  		20.53  LDD1901  [8]
C264
 Probe Info  		26.35  LDD1935  [8]
C265
 Probe Info  		13.64  LDD1936  [8]
C266
 Probe Info  		8.28  LDD1937  [8]
C270
 Probe Info  		6.15  LDD1940  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C91(2.23)  LDD0168  [3]
 LDCM0026  4SU-RNA+native RNA HEK-293T C91(2.08); C368(2.64)  LDD0169  [3]
 LDCM0214  AC1 HCT 116 C88(1.22); C91(1.22); C476(0.87); C482(0.87)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C88(1.16); C91(1.16)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C88(1.05); C91(1.05); C476(0.84); C482(0.84)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C88(1.08); C91(1.08); C476(0.99); C482(0.99)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C88(0.94); C91(0.94); C476(1.08); C482(1.08)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C88(1.04); C91(1.04); C476(1.13); C482(1.13)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C88(0.97); C91(0.97); C476(1.08); C482(1.08)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C88(1.16); C91(1.16); C476(1.02); C482(1.02)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C88(1.12); C91(1.12); C476(0.96); C482(0.96)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C88(1.06); C91(1.28); C476(1.04); C482(1.04)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C88(1.03); C91(0.98); C476(1.15); C482(1.15)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C88(0.88); C91(0.90); C476(1.06); C482(1.06)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C88(1.44); C91(1.44)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C88(0.97); C91(0.92); C476(1.17); C482(1.17)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C88(1.05); C91(0.99); C476(1.13); C482(1.13)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C88(1.18); C91(1.16); C476(1.35); C482(1.35)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C88(1.05); C91(1.05); C476(0.76); C482(0.76)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C88(0.95); C91(0.95); C476(1.12); C482(1.12)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C88(0.93); C91(0.93); C476(1.10); C482(1.06)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C88(0.91); C91(0.91); C476(1.16); C482(0.98)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C88(0.95); C91(0.95); C476(0.93); C482(0.85)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C88(0.84); C91(0.84); C476(0.95); C482(0.79)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C88(0.86); C91(0.86); C476(1.36); C482(0.75)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C88(1.11); C91(1.11)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C88(0.83); C91(0.83); C476(1.06); C482(0.77)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C88(0.99); C91(0.99); C476(1.07); C482(0.85)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C88(0.99); C91(0.99); C476(1.02); C482(1.05)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C88(1.03); C91(1.03); C476(0.93); C482(0.91)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C88(0.94); C91(0.94); C476(1.05); C482(0.92)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C88(0.92); C91(0.92); C476(1.18); C482(1.01)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C88(0.99); C91(0.99); C476(1.11); C482(0.93)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C88(0.95); C91(0.95); C476(0.94); C482(0.92)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C88(1.15); C91(1.15)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C88(1.12); C91(1.12)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C88(1.19); C91(1.19)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C88(1.05); C91(1.05)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C88(1.27); C91(1.27)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C88(1.29); C91(1.29)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C88(1.37); C91(1.37)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C88(1.32); C91(1.32)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C88(1.34); C91(1.34)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C88(1.12); C91(1.12)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C88(1.40); C91(1.40)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C88(1.59); C91(1.59)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C88(1.16); C91(1.16)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C88(1.50); C91(1.50)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C88(1.37); C91(1.37)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C88(1.32); C91(1.32)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C88(0.94); C91(0.94); C476(1.20); C482(1.20)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C91(0.91); C88(1.02); C482(1.07); C476(1.33)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C482(0.88); C88(0.94); C91(1.01); C476(1.30)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C482(0.89); C88(1.02); C91(1.04); C476(1.05)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C88(1.00); C482(1.00); C476(1.05); C91(1.05)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C482(0.73); C476(1.12); C91(1.21); C88(1.63)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C482(0.79); C476(1.10); C91(1.19); C88(1.39)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C88(1.21); C91(1.21)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C476(0.87); C482(0.98); C88(1.13); C91(1.18)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C482(0.80); C476(0.90); C91(1.03); C88(1.29)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C482(0.91); C476(0.95); C91(1.03); C88(1.09)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C91(0.92); C88(0.95); C482(1.03); C476(1.38)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C88(0.87); C91(1.03); C476(1.00); C482(0.95)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C88(1.00); C91(1.05); C476(0.98); C482(0.93)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C88(0.96); C91(0.91); C476(1.00); C482(0.98)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C88(1.06); C91(0.99); C476(1.15); C482(0.96)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C476(0.94); C482(0.94); C88(0.99); C91(0.99)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C476(1.04); C482(1.04); C88(1.18); C91(1.18)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C476(0.98); C482(0.98); C88(0.99); C91(0.99)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C476(0.91); C482(0.91); C88(1.24); C91(1.24)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C88(0.96); C91(0.96); C476(1.08); C482(1.08)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C88(1.03); C91(1.03); C476(1.06); C482(1.06)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C88(0.83); C91(0.83); C476(1.06); C482(1.06)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C476(1.06); C482(1.06); C88(1.19); C91(1.19)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C88(1.02); C91(1.02); C476(1.06); C482(1.06)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C88(1.07); C91(1.07); C476(1.09); C482(1.09)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C88(1.12); C91(1.12); C476(1.22); C482(1.22)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C88(1.16); C91(1.16); C476(1.26); C482(1.26)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C88(1.01); C91(1.01); C476(1.23); C482(1.23)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C88(1.16); C91(1.16); C476(1.50); C482(1.50)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C476(1.04); C482(1.04); C88(1.14); C91(1.14)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C88(1.32); C91(1.32); C476(1.40); C482(1.40)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C88(1.04); C91(1.04); C476(1.21); C482(1.21)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C88(1.35); C91(1.35); C476(1.38); C482(1.38)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C476(1.13); C482(1.13); C88(1.29); C91(1.29)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C88(1.53); C91(1.53); C476(1.57); C482(1.57)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C88(0.91); C91(0.91); C476(1.15); C482(1.15)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C88(1.04); C91(1.04); C476(1.10); C482(1.10)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C88(1.10); C91(1.10); C476(1.24); C482(1.24)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C476(1.04); C482(1.04); C88(1.13); C91(1.13)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C476(1.05); C482(1.05); C88(1.07); C91(1.07)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C476(0.94); C482(0.94); C88(1.23); C91(1.23)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C88(1.33); C91(1.33); C476(1.49); C482(1.49)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C88(1.09); C91(1.09); C476(1.48); C482(1.48)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C476(1.21); C482(1.21); C88(1.21); C91(1.21)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C88(1.26); C91(1.26); C476(1.57); C482(1.57)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C88(1.21); C91(1.21); C476(1.71); C482(1.71)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C88(1.42); C91(1.42); C476(1.66); C482(1.66)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C476(1.23); C482(1.23)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C476(1.03); C482(1.03)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C476(1.21); C482(1.21)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C476(1.29); C482(1.29)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C476(1.25); C482(1.25); C88(1.30); C91(1.30)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C476(1.45); C482(1.45)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C476(1.34); C482(1.34)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C476(1.41); C482(1.41)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C476(1.37); C482(1.37)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C476(1.22); C482(1.22)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C476(1.04); C482(1.04)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C476(1.45); C482(1.45)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C476(0.49); C482(0.49); C88(1.26); C91(1.26)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C476(0.54); C482(0.54); C88(1.31); C91(1.31)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C476(0.67); C482(0.67); C88(1.17); C91(1.17)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C88(1.20); C91(1.20)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C476(0.63); C482(0.63); C88(1.29); C91(1.29)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C476(0.52); C482(0.52); C88(1.29); C91(1.29)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C476(0.50); C482(0.50); C88(1.28); C91(1.28)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C476(0.58); C482(0.58); C88(1.30); C91(1.30)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C476(0.50); C482(0.50); C88(1.35); C91(1.35)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C476(0.50); C482(0.50); C88(1.52); C91(1.52)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C476(0.57); C482(0.57); C88(1.34); C91(1.34)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C476(0.65); C482(0.65); C88(1.65); C91(1.65)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C476(1.01); C482(1.01); C88(1.05); C91(1.05)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C476(0.98); C482(0.98); C88(1.12); C91(1.12)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C88(1.08); C91(1.08)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C476(1.03); C482(1.03); C88(1.04); C91(1.04)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C476(0.83); C482(0.83); C88(0.99); C91(0.99)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C476(1.04); C482(1.04); C88(1.14); C91(1.14)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C88(1.51); C91(1.51); C476(1.07); C482(1.07)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C476(0.83); C482(0.83); C88(1.29); C91(1.29)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C476(1.07); C482(1.07); C88(1.70); C91(1.70)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C476(0.80); C482(0.80); C88(1.21); C91(1.21)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C476(1.12); C482(1.12); C88(1.14); C91(1.14)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C88(1.03); C91(1.03); C476(1.07); C482(1.07)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C476(1.13); C482(1.13); C88(1.14); C91(1.14)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C88(1.18); C91(1.18)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C476(0.86); C482(0.86); C88(1.07); C91(1.07)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C88(1.00); C91(1.00); C476(1.32); C482(1.32)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C476(0.98); C482(0.98); C88(1.46); C91(1.46)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C476(0.90); C482(0.90); C88(1.00); C91(1.00)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C476(0.94); C482(0.94); C88(1.11); C91(1.11)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C88(0.94); C91(0.94); C476(0.96); C482(0.96)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C476(1.20); C482(1.20); C88(1.35); C91(1.35)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C476(1.15); C482(1.15); C88(1.34); C91(1.34)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C88(1.23); C91(1.23); C476(1.26); C482(1.26)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C88(1.20); C91(1.20); C476(1.31); C482(1.31)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C88(1.15); C91(1.15); C476(1.23); C482(1.23)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C476(0.94); C482(0.94); C88(1.04); C91(1.04)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C476(1.00); C482(1.00); C88(1.13); C91(1.13)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C476(1.09); C482(1.09); C88(1.29); C91(1.29)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C88(0.81); C91(0.81); C476(0.84); C482(0.84)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C88(1.31); C91(1.31); C476(1.35); C482(1.35)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C476(0.88); C482(0.88); C88(0.98); C91(0.98)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C476(1.60); C482(1.60); C88(1.82); C91(1.82)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C476(1.09); C482(1.09); C88(1.32); C91(1.32)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C476(0.91); C482(0.91); C88(1.07); C91(1.07)  LDD0683  [5]
 LDCM0248  AKOS034007472 HCT 116 C88(1.12); C91(1.12)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C88(1.36); C91(1.36)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C88(1.67); C91(1.67)  LDD0592  [5]
 LDCM0020  ARS-1620 HCC44 C476(1.19); C482(1.19)  LDD0078  [5]
 LDCM0367  CL1 HCT 116 C476(0.45); C482(0.45)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C476(0.70); C482(0.70)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C476(0.97); C482(0.97); C88(1.40); C91(1.40)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C88(1.49); C91(1.49)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C88(1.37); C91(1.37)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C88(1.49); C91(1.49)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C88(1.50); C91(1.50)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C476(0.82); C482(0.82); C88(1.69); C91(1.69)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C476(0.77); C482(0.77); C88(1.60); C91(1.60)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C476(0.79); C482(0.79); C88(1.36); C91(1.36)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C476(0.98); C482(0.98); C88(1.95); C91(1.95)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C476(1.07); C482(1.07); C88(1.52); C91(1.52)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C476(0.73); C482(0.73)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C476(1.06); C482(1.06); C88(2.31); C91(2.31)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C476(1.29); C482(1.29); C88(1.78); C91(1.78)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C476(1.42); C482(1.42); C88(1.64); C91(1.64)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C88(1.25); C91(1.25); C476(1.42); C482(1.42)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C476(1.59); C482(1.59); C88(2.06); C91(2.06)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C476(1.32); C482(1.32); C88(1.92); C91(1.92)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C476(1.10); C482(1.10); C88(1.42); C91(1.42)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C476(1.44); C482(1.44); C88(2.51); C91(2.51)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C476(1.12); C482(1.12); C88(1.26); C91(1.26)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C88(1.16); C91(1.16); C476(1.25); C482(1.25)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C476(0.96); C482(0.96)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C88(1.14); C91(1.14); C476(1.17); C482(1.17)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C476(1.08); C482(1.08)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C476(1.08); C482(1.08)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C476(1.33); C482(1.33)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C476(1.29); C482(1.29)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C476(0.70); C482(0.70); C88(1.51); C91(1.51)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C476(1.08); C482(1.08); C88(1.57); C91(1.57)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C476(0.71); C482(0.71); C88(1.26); C91(1.26)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C476(0.76); C482(0.76); C88(1.35); C91(1.35)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C476(0.88); C482(0.88)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C476(0.70); C482(0.70)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C476(1.08); C482(1.08)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C88(1.40); C91(1.40)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C88(1.34); C91(1.34)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C88(1.04); C91(1.04)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C88(1.27); C91(1.27)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C476(0.77); C482(0.77)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C88(0.99); C91(0.99)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C88(3.17); C91(3.17)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C88(1.29); C91(1.29)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C88(1.22); C91(1.22)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C88(1.01); C91(1.01)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C88(1.39); C91(1.39)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C88(1.16); C91(1.16)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C88(1.27); C91(1.27)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C88(1.46); C91(1.46)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C88(1.00); C91(1.00)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C476(0.34); C482(0.34)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C88(1.01); C91(1.01)  LDD0736  [5]
 LDCM0420  CL31 PaTu 8988t C88(1.81); C91(1.81)  LDD1299  [5]
 LDCM0421  CL32 PaTu 8988t C88(1.71); C91(1.71)  LDD1300  [5]
 LDCM0422  CL33 PaTu 8988t C88(7.39); C91(7.39)  LDD1301  [5]
 LDCM0423  CL34 PaTu 8988t C88(3.15); C91(3.15)  LDD1302  [5]
 LDCM0424  CL35 PaTu 8988t C88(2.09); C91(2.09)  LDD1303  [5]
 LDCM0425  CL36 PaTu 8988t C88(3.45); C91(3.45)  LDD1304  [5]
 LDCM0426  CL37 PaTu 8988t C88(1.97); C91(1.97)  LDD1305  [5]
 LDCM0428  CL39 PaTu 8988t C88(2.37); C91(2.37)  LDD1307  [5]
 LDCM0429  CL4 HCT 116 C476(0.59); C482(0.59)  LDD0746  [5]
 LDCM0430  CL40 PaTu 8988t C88(1.41); C91(1.41)  LDD1309  [5]
 LDCM0431  CL41 PaTu 8988t C88(4.53); C91(4.53)  LDD1310  [5]
 LDCM0432  CL42 PaTu 8988t C88(2.00); C91(2.00)  LDD1311  [5]
 LDCM0433  CL43 PaTu 8988t C88(2.41); C91(2.41)  LDD1312  [5]
 LDCM0434  CL44 PaTu 8988t C88(1.69); C91(1.69)  LDD1313  [5]
 LDCM0435  CL45 PaTu 8988t C88(4.82); C91(4.82)  LDD1314  [5]
 LDCM0436  CL46 HCT 116 C88(1.00); C91(1.00); C476(0.96); C482(0.96)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C88(1.00); C91(1.00); C476(1.13); C482(1.13)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C88(0.79); C91(0.79); C476(0.92); C482(0.92)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C88(0.99); C91(0.99); C476(0.89); C482(0.89)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C476(0.52); C482(0.52)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C88(0.98); C91(0.98); C476(0.83); C482(0.83)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C88(0.80); C91(0.80); C476(1.04); C482(1.04)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C88(0.75); C91(0.75); C476(1.16); C482(1.16)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C88(1.79); C91(1.79); C476(1.11); C482(1.11)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C88(1.08); C91(1.08); C476(0.97); C482(0.97)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C88(0.78); C91(0.78); C476(0.89); C482(0.89)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C88(1.13); C91(1.13); C476(0.92); C482(0.92)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C88(1.13); C91(1.13); C476(1.11); C482(1.11)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C88(0.80); C91(0.80); C476(0.98); C482(0.98)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C88(0.87); C91(0.87); C476(0.89); C482(0.89)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C476(0.61); C482(0.61)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C88(1.57); C91(1.57); C476(0.88); C482(0.88)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C88(1.28); C91(1.28); C476(0.92); C482(0.92)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C88(1.65); C91(1.65); C476(0.85); C482(0.85)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C88(1.67); C91(1.67); C476(1.39); C482(1.39)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C88(2.82); C91(2.82); C476(2.03); C482(2.03)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C88(1.17); C91(1.17); C476(0.98); C482(0.98)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C88(4.05); C91(4.05); C476(2.36); C482(2.36)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C88(1.52); C91(1.52); C476(1.01); C482(1.01)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C88(3.00); C91(3.00); C476(0.90); C482(0.90)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C88(3.03); C91(3.03); C476(1.34); C482(1.34)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C476(0.61); C482(0.61)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C88(1.30); C91(1.30); C476(1.18); C482(1.18)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C88(1.90); C91(1.90); C476(1.77); C482(1.77)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C88(1.28); C91(1.28); C476(1.07); C482(1.07)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C88(1.84); C91(1.84); C476(0.93); C482(0.93)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C88(1.78); C91(1.78); C476(0.66); C482(0.66)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C88(0.86); C91(0.86)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C88(1.11); C91(1.11)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C88(0.87); C91(0.87)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C88(0.95); C91(0.95)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C476(1.16); C482(1.16)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C88(0.91); C91(0.91)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C88(1.03); C91(1.03)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C88(1.02); C91(1.02)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C88(1.29); C91(1.29)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C88(1.09); C91(1.09)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C88(1.01); C91(1.01)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C88(0.88); C91(0.88)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C88(1.11); C91(1.11)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C88(0.88); C91(0.88)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C88(0.96); C91(0.96)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C476(0.53); C482(0.53)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C88(1.24); C91(1.24)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C88(1.23); C91(1.23); C476(0.93); C482(0.93)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C88(2.29); C91(2.29); C476(1.05); C482(1.05)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C88(1.22); C91(1.22); C476(0.88); C482(0.88)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C88(2.14); C91(2.14); C476(1.05); C482(1.05)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C88(2.13); C91(2.13); C476(1.02); C482(1.02)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C88(1.47); C91(1.47); C476(1.11); C482(1.11)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C88(1.31); C91(1.31); C476(1.03); C482(1.03)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C88(1.78); C91(1.78); C476(0.92); C482(0.92)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C88(1.53); C91(1.53); C476(1.01); C482(1.01)  LDD0811  [5]
 LDCM0495  E2913 HEK-293T C368(1.22)  LDD1698  [9]
 LDCM0468  Fragment33 HCT 116 C88(1.68); C91(1.68); C476(1.04); C482(1.04)  LDD0785  [5]
 LDCM0427  Fragment51 PaTu 8988t C88(1.81); C91(1.81)  LDD1306  [5]
 LDCM0022  KB02 HCT 116 C476(3.51); C482(3.51)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C476(2.23); C482(2.23)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C476(2.74); C482(2.74)  LDD0082  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Receptor-type tyrosine-protein phosphatase-like N (PTPRN) Protein-tyrosine phosphatase family Q16849

References

1 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
8 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402