Details of the Target

General Information of Target

Target ID LDTP00397
Target Name Golgi SNAP receptor complex member 2 (GOSR2)
Gene Name GOSR2
Gene ID 9570
Synonyms
GS27; Golgi SNAP receptor complex member 2; 27 kDa Golgi SNARE protein; Membrin
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDPLFQQTHKQVHEIQSCMGRLETADKQSVHIVENEIQASIDQIFSRLERLEILSSKEPP
NKRQNARLRVDQLKYDVQHLQTALRNFQHRRHAREQQERQREELLSRTFTTNDSDTTIPM
DESLQFNSSLQKVHNGMDDLILDGHNILDGLRTQRLTLKGTQKKILDIANMLGLSNTVMR
LIEKRAFQDKYFMIGGMLLTCVVMFLVVQYLT
Target Bioclass
Other
Family
GOSR2 family
Subcellular location
Golgi apparatus, cis-Golgi network membrane
Function Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.
Uniprot ID
O14653
Ensemble ID
ENST00000225567.9
HGNC ID
HGNC:4431

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HLF SNV: p.T24K .
HT115 SNV: p.H134N DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K159(5.60); K164(10.00); K57(0.69)  LDD0277  [1]
IPM
 Probe Info  		N.A.  LDD0241  [2]
m-APA
 Probe Info  		14.07  LDD0403  [3]
DBIA
 Probe Info  		C18(1.26)  LDD3310  [4]
BTD
 Probe Info  		C18(1.07)  LDD2093  [5]
Acrolein
 Probe Info  		N.A.  LDD0223  [6]
5E-2FA
 Probe Info  		N.A.  LDD2235  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [8]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [8]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [8]
SF
 Probe Info  		N.A.  LDD0028  [9]
W1
 Probe Info  		N.A.  LDD0236  [2]
NAIA_5
 Probe Info  		N.A.  LDD2223  [10]
PAL-AfBPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C056
 Probe Info  		18.90  LDD1753  [11]
C091
 Probe Info  		23.10  LDD1782  [11]
C092
 Probe Info  		44.02  LDD1783  [11]
C094
 Probe Info  		61.39  LDD1785  [11]
C106
 Probe Info  		17.75  LDD1793  [11]
C112
 Probe Info  		19.97  LDD1799  [11]
C169
 Probe Info  		20.11  LDD1849  [11]
C178
 Probe Info  		15.67  LDD1857  [11]
C278
 Probe Info  		61.82  LDD1948  [11]
C285
 Probe Info  		21.11  LDD1955  [11]
C287
 Probe Info  		9.06  LDD1957  [11]
C289
 Probe Info  		48.50  LDD1959  [11]
C362
 Probe Info  		45.89  LDD2023  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C18(0.86)  LDD2117  [5]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C18(1.00)  LDD2152  [5]
 LDCM0214  AC1 HEK-293T C18(1.01)  LDD1507  [12]
 LDCM0215  AC10 HEK-293T C18(0.97)  LDD1508  [12]
 LDCM0226  AC11 HEK-293T C18(0.96)  LDD1509  [12]
 LDCM0237  AC12 HEK-293T C18(0.98)  LDD1510  [12]
 LDCM0259  AC14 HEK-293T C18(0.94)  LDD1512  [12]
 LDCM0270  AC15 HEK-293T C18(0.86)  LDD1513  [12]
 LDCM0276  AC17 HEK-293T C18(1.00)  LDD1515  [12]
 LDCM0277  AC18 HEK-293T C18(1.01)  LDD1516  [12]
 LDCM0278  AC19 HEK-293T C18(0.95)  LDD1517  [12]
 LDCM0279  AC2 HEK-293T C18(1.02)  LDD1518  [12]
 LDCM0280  AC20 HEK-293T C18(1.03)  LDD1519  [12]
 LDCM0281  AC21 HEK-293T C18(1.08)  LDD1520  [12]
 LDCM0282  AC22 HEK-293T C18(0.98)  LDD1521  [12]
 LDCM0283  AC23 HEK-293T C18(0.88)  LDD1522  [12]
 LDCM0284  AC24 HEK-293T C18(0.98)  LDD1523  [12]
 LDCM0285  AC25 HEK-293T C18(0.96)  LDD1524  [12]
 LDCM0286  AC26 HEK-293T C18(1.02)  LDD1525  [12]
 LDCM0287  AC27 HEK-293T C18(1.04)  LDD1526  [12]
 LDCM0288  AC28 HEK-293T C18(0.96)  LDD1527  [12]
 LDCM0289  AC29 HEK-293T C18(1.04)  LDD1528  [12]
 LDCM0290  AC3 HEK-293T C18(0.89)  LDD1529  [12]
 LDCM0291  AC30 HEK-293T C18(0.94)  LDD1530  [12]
 LDCM0292  AC31 HEK-293T C18(0.94)  LDD1531  [12]
 LDCM0293  AC32 HEK-293T C18(0.94)  LDD1532  [12]
 LDCM0294  AC33 HEK-293T C18(1.01)  LDD1533  [12]
 LDCM0295  AC34 HEK-293T C18(0.99)  LDD1534  [12]
 LDCM0296  AC35 HEK-293T C18(1.09)  LDD1535  [12]
 LDCM0297  AC36 HEK-293T C18(1.05)  LDD1536  [12]
 LDCM0298  AC37 HEK-293T C18(1.08)  LDD1537  [12]
 LDCM0299  AC38 HEK-293T C18(0.94)  LDD1538  [12]
 LDCM0300  AC39 HEK-293T C18(0.91)  LDD1539  [12]
 LDCM0301  AC4 HEK-293T C18(0.95)  LDD1540  [12]
 LDCM0302  AC40 HEK-293T C18(0.96)  LDD1541  [12]
 LDCM0303  AC41 HEK-293T C18(1.05)  LDD1542  [12]
 LDCM0304  AC42 HEK-293T C18(1.06)  LDD1543  [12]
 LDCM0305  AC43 HEK-293T C18(1.01)  LDD1544  [12]
 LDCM0306  AC44 HEK-293T C18(1.01)  LDD1545  [12]
 LDCM0307  AC45 HEK-293T C18(1.00)  LDD1546  [12]
 LDCM0308  AC46 HEK-293T C18(1.06)  LDD1547  [12]
 LDCM0309  AC47 HEK-293T C18(0.83)  LDD1548  [12]
 LDCM0310  AC48 HEK-293T C18(0.97)  LDD1549  [12]
 LDCM0311  AC49 HEK-293T C18(1.04)  LDD1550  [12]
 LDCM0312  AC5 HEK-293T C18(1.03)  LDD1551  [12]
 LDCM0313  AC50 HEK-293T C18(1.00)  LDD1552  [12]
 LDCM0314  AC51 HEK-293T C18(1.00)  LDD1553  [12]
 LDCM0315  AC52 HEK-293T C18(1.02)  LDD1554  [12]
 LDCM0316  AC53 HEK-293T C18(1.07)  LDD1555  [12]
 LDCM0317  AC54 HEK-293T C18(0.98)  LDD1556  [12]
 LDCM0318  AC55 HEK-293T C18(0.84)  LDD1557  [12]
 LDCM0319  AC56 HEK-293T C18(0.93)  LDD1558  [12]
 LDCM0320  AC57 HEK-293T C18(1.03)  LDD1559  [12]
 LDCM0321  AC58 HEK-293T C18(1.02)  LDD1560  [12]
 LDCM0322  AC59 HEK-293T C18(0.89)  LDD1561  [12]
 LDCM0323  AC6 HEK-293T C18(0.93)  LDD1562  [12]
 LDCM0324  AC60 HEK-293T C18(0.98)  LDD1563  [12]
 LDCM0325  AC61 HEK-293T C18(1.03)  LDD1564  [12]
 LDCM0326  AC62 HEK-293T C18(1.05)  LDD1565  [12]
 LDCM0327  AC63 HEK-293T C18(0.86)  LDD1566  [12]
 LDCM0328  AC64 HEK-293T C18(0.96)  LDD1567  [12]
 LDCM0334  AC7 HEK-293T C18(0.78)  LDD1568  [12]
 LDCM0345  AC8 HEK-293T C18(0.94)  LDD1569  [12]
 LDCM0520  AKOS000195272 MDA-MB-231 C18(0.68)  LDD2113  [5]
 LDCM0248  AKOS034007472 HEK-293T C18(1.11)  LDD1511  [12]
 LDCM0356  AKOS034007680 HEK-293T C18(1.01)  LDD1570  [12]
 LDCM0275  AKOS034007705 HEK-293T C18(0.98)  LDD1514  [12]
 LDCM0156  Aniline NCI-H1299 14.07  LDD0403  [3]
 LDCM0367  CL1 HEK-293T C18(0.77)  LDD1571  [12]
 LDCM0368  CL10 HEK-293T C18(0.89)  LDD1572  [12]
 LDCM0369  CL100 HEK-293T C18(1.04)  LDD1573  [12]
 LDCM0370  CL101 HEK-293T C18(0.80)  LDD1574  [12]
 LDCM0371  CL102 HEK-293T C18(0.96)  LDD1575  [12]
 LDCM0372  CL103 HEK-293T C18(1.02)  LDD1576  [12]
 LDCM0373  CL104 HEK-293T C18(0.98)  LDD1577  [12]
 LDCM0374  CL105 HEK-293T C18(0.75)  LDD1578  [12]
 LDCM0375  CL106 HEK-293T C18(0.94)  LDD1579  [12]
 LDCM0376  CL107 HEK-293T C18(1.01)  LDD1580  [12]
 LDCM0377  CL108 HEK-293T C18(1.11)  LDD1581  [12]
 LDCM0378  CL109 HEK-293T C18(0.98)  LDD1582  [12]
 LDCM0379  CL11 HEK-293T C18(0.75)  LDD1583  [12]
 LDCM0380  CL110 HEK-293T C18(0.98)  LDD1584  [12]
 LDCM0381  CL111 HEK-293T C18(1.03)  LDD1585  [12]
 LDCM0382  CL112 HEK-293T C18(1.24)  LDD1586  [12]
 LDCM0383  CL113 HEK-293T C18(1.11)  LDD1587  [12]
 LDCM0384  CL114 HEK-293T C18(0.86)  LDD1588  [12]
 LDCM0385  CL115 HEK-293T C18(0.95)  LDD1589  [12]
 LDCM0386  CL116 HEK-293T C18(1.03)  LDD1590  [12]
 LDCM0387  CL117 HEK-293T C18(0.86)  LDD1591  [12]
 LDCM0388  CL118 HEK-293T C18(0.95)  LDD1592  [12]
 LDCM0389  CL119 HEK-293T C18(1.00)  LDD1593  [12]
 LDCM0390  CL12 HEK-293T C18(0.93)  LDD1594  [12]
 LDCM0391  CL120 HEK-293T C18(0.99)  LDD1595  [12]
 LDCM0392  CL121 HEK-293T C18(0.69)  LDD1596  [12]
 LDCM0393  CL122 HEK-293T C18(0.93)  LDD1597  [12]
 LDCM0394  CL123 HEK-293T C18(0.86)  LDD1598  [12]
 LDCM0395  CL124 HEK-293T C18(0.99)  LDD1599  [12]
 LDCM0396  CL125 HEK-293T C18(0.94)  LDD1600  [12]
 LDCM0397  CL126 HEK-293T C18(0.94)  LDD1601  [12]
 LDCM0398  CL127 HEK-293T C18(1.06)  LDD1602  [12]
 LDCM0399  CL128 HEK-293T C18(1.03)  LDD1603  [12]
 LDCM0400  CL13 HEK-293T C18(0.91)  LDD1604  [12]
 LDCM0401  CL14 HEK-293T C18(0.95)  LDD1605  [12]
 LDCM0402  CL15 HEK-293T C18(0.89)  LDD1606  [12]
 LDCM0403  CL16 HEK-293T C18(1.02)  LDD1607  [12]
 LDCM0404  CL17 HEK-293T C18(1.01)  LDD1608  [12]
 LDCM0405  CL18 HEK-293T C18(0.98)  LDD1609  [12]
 LDCM0406  CL19 HEK-293T C18(0.97)  LDD1610  [12]
 LDCM0407  CL2 HEK-293T C18(0.89)  LDD1611  [12]
 LDCM0408  CL20 HEK-293T C18(1.04)  LDD1612  [12]
 LDCM0409  CL21 HEK-293T C18(1.03)  LDD1613  [12]
 LDCM0410  CL22 HEK-293T C18(0.96)  LDD1614  [12]
 LDCM0411  CL23 HEK-293T C18(0.94)  LDD1615  [12]
 LDCM0412  CL24 HEK-293T C18(0.88)  LDD1616  [12]
 LDCM0413  CL25 HEK-293T C18(0.99)  LDD1617  [12]
 LDCM0414  CL26 HEK-293T C18(0.89)  LDD1618  [12]
 LDCM0415  CL27 HEK-293T C18(1.00)  LDD1619  [12]
 LDCM0416  CL28 HEK-293T C18(1.10)  LDD1620  [12]
 LDCM0417  CL29 HEK-293T C18(0.98)  LDD1621  [12]
 LDCM0418  CL3 HEK-293T C18(0.87)  LDD1622  [12]
 LDCM0419  CL30 HEK-293T C18(0.98)  LDD1623  [12]
 LDCM0420  CL31 HEK-293T C18(1.01)  LDD1624  [12]
 LDCM0421  CL32 HEK-293T C18(1.00)  LDD1625  [12]
 LDCM0422  CL33 HEK-293T C18(0.89)  LDD1626  [12]
 LDCM0423  CL34 HEK-293T C18(0.96)  LDD1627  [12]
 LDCM0424  CL35 HEK-293T C18(0.91)  LDD1628  [12]
 LDCM0425  CL36 HEK-293T C18(0.96)  LDD1629  [12]
 LDCM0426  CL37 HEK-293T C18(0.93)  LDD1630  [12]
 LDCM0428  CL39 HEK-293T C18(0.94)  LDD1632  [12]
 LDCM0429  CL4 HEK-293T C18(1.09)  LDD1633  [12]
 LDCM0430  CL40 HEK-293T C18(1.02)  LDD1634  [12]
 LDCM0431  CL41 HEK-293T C18(0.97)  LDD1635  [12]
 LDCM0432  CL42 HEK-293T C18(1.07)  LDD1636  [12]
 LDCM0433  CL43 HEK-293T C18(1.04)  LDD1637  [12]
 LDCM0434  CL44 HEK-293T C18(1.01)  LDD1638  [12]
 LDCM0435  CL45 HEK-293T C18(1.00)  LDD1639  [12]
 LDCM0436  CL46 HEK-293T C18(0.90)  LDD1640  [12]
 LDCM0437  CL47 HEK-293T C18(0.91)  LDD1641  [12]
 LDCM0438  CL48 HEK-293T C18(0.97)  LDD1642  [12]
 LDCM0439  CL49 HEK-293T C18(0.75)  LDD1643  [12]
 LDCM0440  CL5 HEK-293T C18(1.03)  LDD1644  [12]
 LDCM0441  CL50 HEK-293T C18(0.96)  LDD1645  [12]
 LDCM0443  CL52 HEK-293T C18(1.01)  LDD1646  [12]
 LDCM0444  CL53 HEK-293T C18(0.96)  LDD1647  [12]
 LDCM0445  CL54 HEK-293T C18(0.89)  LDD1648  [12]
 LDCM0446  CL55 HEK-293T C18(1.05)  LDD1649  [12]
 LDCM0447  CL56 HEK-293T C18(1.03)  LDD1650  [12]
 LDCM0448  CL57 HEK-293T C18(0.95)  LDD1651  [12]
 LDCM0449  CL58 HEK-293T C18(0.88)  LDD1652  [12]
 LDCM0450  CL59 HEK-293T C18(0.92)  LDD1653  [12]
 LDCM0451  CL6 HEK-293T C18(0.88)  LDD1654  [12]
 LDCM0452  CL60 HEK-293T C18(0.93)  LDD1655  [12]
 LDCM0453  CL61 HEK-293T C18(0.99)  LDD1656  [12]
 LDCM0454  CL62 HEK-293T C18(1.09)  LDD1657  [12]
 LDCM0455  CL63 HEK-293T C18(0.96)  LDD1658  [12]
 LDCM0456  CL64 HEK-293T C18(0.97)  LDD1659  [12]
 LDCM0457  CL65 HEK-293T C18(1.04)  LDD1660  [12]
 LDCM0458  CL66 HEK-293T C18(1.03)  LDD1661  [12]
 LDCM0459  CL67 HEK-293T C18(0.98)  LDD1662  [12]
 LDCM0460  CL68 HEK-293T C18(0.99)  LDD1663  [12]
 LDCM0461  CL69 HEK-293T C18(0.94)  LDD1664  [12]
 LDCM0462  CL7 HEK-293T C18(1.01)  LDD1665  [12]
 LDCM0463  CL70 HEK-293T C18(0.93)  LDD1666  [12]
 LDCM0464  CL71 HEK-293T C18(0.91)  LDD1667  [12]
 LDCM0465  CL72 HEK-293T C18(1.01)  LDD1668  [12]
 LDCM0466  CL73 HEK-293T C18(0.87)  LDD1669  [12]
 LDCM0467  CL74 HEK-293T C18(0.94)  LDD1670  [12]
 LDCM0469  CL76 HEK-293T C18(0.99)  LDD1672  [12]
 LDCM0470  CL77 HEK-293T C18(1.01)  LDD1673  [12]
 LDCM0471  CL78 HEK-293T C18(0.96)  LDD1674  [12]
 LDCM0472  CL79 HEK-293T C18(0.88)  LDD1675  [12]
 LDCM0473  CL8 HEK-293T C18(0.85)  LDD1676  [12]
 LDCM0474  CL80 HEK-293T C18(0.95)  LDD1677  [12]
 LDCM0475  CL81 HEK-293T C18(0.98)  LDD1678  [12]
 LDCM0476  CL82 HEK-293T C18(0.94)  LDD1679  [12]
 LDCM0477  CL83 HEK-293T C18(0.80)  LDD1680  [12]
 LDCM0478  CL84 HEK-293T C18(0.93)  LDD1681  [12]
 LDCM0479  CL85 HEK-293T C18(0.82)  LDD1682  [12]
 LDCM0480  CL86 HEK-293T C18(0.85)  LDD1683  [12]
 LDCM0481  CL87 HEK-293T C18(0.98)  LDD1684  [12]
 LDCM0482  CL88 HEK-293T C18(0.97)  LDD1685  [12]
 LDCM0483  CL89 HEK-293T C18(1.02)  LDD1686  [12]
 LDCM0484  CL9 HEK-293T C18(1.01)  LDD1687  [12]
 LDCM0485  CL90 HEK-293T C18(0.78)  LDD1688  [12]
 LDCM0486  CL91 HEK-293T C18(0.89)  LDD1689  [12]
 LDCM0487  CL92 HEK-293T C18(1.01)  LDD1690  [12]
 LDCM0488  CL93 HEK-293T C18(1.01)  LDD1691  [12]
 LDCM0489  CL94 HEK-293T C18(0.93)  LDD1692  [12]
 LDCM0490  CL95 HEK-293T C18(0.70)  LDD1693  [12]
 LDCM0491  CL96 HEK-293T C18(0.93)  LDD1694  [12]
 LDCM0492  CL97 HEK-293T C18(0.97)  LDD1695  [12]
 LDCM0493  CL98 HEK-293T C18(0.88)  LDD1696  [12]
 LDCM0494  CL99 HEK-293T C18(0.99)  LDD1697  [12]
 LDCM0495  E2913 HEK-293T C18(1.00)  LDD1698  [12]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C18(1.02)  LDD1702  [5]
 LDCM0625  F8 Ramos C18(2.16)  LDD2187  [13]
 LDCM0572  Fragment10 Ramos C18(0.58)  LDD2189  [13]
 LDCM0573  Fragment11 Ramos C18(0.16)  LDD2190  [13]
 LDCM0574  Fragment12 Ramos C18(0.24)  LDD2191  [13]
 LDCM0575  Fragment13 Ramos C18(0.31)  LDD2192  [13]
 LDCM0576  Fragment14 Ramos C18(0.38)  LDD2193  [13]
 LDCM0579  Fragment20 Ramos C18(0.30)  LDD2194  [13]
 LDCM0580  Fragment21 Ramos C18(0.39)  LDD2195  [13]
 LDCM0582  Fragment23 Ramos C18(0.36)  LDD2196  [13]
 LDCM0578  Fragment27 Ramos C18(1.01)  LDD2197  [13]
 LDCM0586  Fragment28 Ramos C18(0.84)  LDD2198  [13]
 LDCM0588  Fragment30 Ramos C18(0.75)  LDD2199  [13]
 LDCM0589  Fragment31 Ramos C18(0.32)  LDD2200  [13]
 LDCM0590  Fragment32 Ramos C18(0.61)  LDD2201  [13]
 LDCM0468  Fragment33 HEK-293T C18(1.02)  LDD1671  [12]
 LDCM0596  Fragment38 Ramos C18(0.13)  LDD2203  [13]
 LDCM0566  Fragment4 Ramos C18(0.55)  LDD2184  [13]
 LDCM0427  Fragment51 HEK-293T C18(0.99)  LDD1631  [12]
 LDCM0610  Fragment52 Ramos C18(0.58)  LDD2204  [13]
 LDCM0614  Fragment56 Ramos C18(0.66)  LDD2205  [13]
 LDCM0569  Fragment7 Ramos C18(0.45)  LDD2186  [13]
 LDCM0571  Fragment9 Ramos C18(0.64)  LDD2188  [13]
 LDCM0022  KB02 HEK-293T C18(1.06)  LDD1492  [12]
 LDCM0023  KB03 HEK-293T C18(1.04)  LDD1497  [12]
 LDCM0024  KB05 COLO792 C18(1.26)  LDD3310  [4]
 LDCM0109  NEM HeLa N.A.  LDD0223  [6]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C18(1.07)  LDD2093  [5]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C18(1.23)  LDD2094  [5]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C18(0.95)  LDD2097  [5]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C18(0.75)  LDD2098  [5]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C18(0.85)  LDD2099  [5]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C18(0.67)  LDD2100  [5]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C18(1.45)  LDD2105  [5]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C18(1.28)  LDD2111  [5]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C18(2.87)  LDD2119  [5]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C18(0.56)  LDD2123  [5]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C18(0.88)  LDD2127  [5]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C18(0.75)  LDD2137  [5]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C18(0.56)  LDD2141  [5]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C18(2.39)  LDD2144  [5]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C18(1.21)  LDD2146  [5]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C18(0.48)  LDD2148  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 13 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) EBP family Q15125
Very long chain fatty acid elongase 4 (ELOVL4) ELO family Q9GZR5
Very long chain fatty acid elongase 5 (ELOVL5) ELO family Q9NYP7
Probable glutathione peroxidase 8 (GPX8) Glutathione peroxidase family Q8TED1
3-hydroxyisobutyrate dehydrogenase, mitochondrial (HIBADH) HIBADH-related family P31937
E3 ubiquitin-protein ligase pellino homolog 1 (PELI1) Pellino family Q96FA3
E3 ubiquitin-protein ligase RNF19B (RNF19B) RBR family Q6ZMZ0
17-beta-hydroxysteroid dehydrogenase 13 (HSD17B13) Short-chain dehydrogenases/reductases (SDR) family Q7Z5P4
ADP-ribosylation factor-like protein 13B (ARL13B) Arf family Q3SXY8
TLC domain-containing protein 4 (TLCD4) TLCD4 family Q96MV1
E3 ubiquitin-protein ligase MARCHF8 (MARCHF8) . Q5T0T0
Plasma membrane ascorbate-dependent reductase CYBRD1 (CYBRD1) . Q53TN4
Transmembrane ascorbate-dependent reductase CYB561 (CYB561) . P49447
Transporter and channel
Click To Hide/Show 15 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hepatic sodium/bile acid cotransporter (SLC10A1) Bile acid:sodium symporter (BASS) family Q14973
Sodium-dependent organic anion transporter (SLC10A6) Bile acid:sodium symporter (BASS) family Q3KNW5
Novel acetylcholine receptor chaperone (TMEM35A) DoxX family Q53FP2
Transmembrane 4 L6 family member 19 (TM4SF19) L6 tetraspanin family Q96DZ7
Hippocampus abundant transcript-like protein 1 (MFSD14B) Major facilitator superfamily Q5SR56
Molybdate-anion transporter (MFSD5) Major facilitator superfamily Q6N075
ER membrane protein complex subunit 5 (MMGT1) Membrane magnesium transporter (TC 1.A.67) family Q8N4V1
Aquaporin-6 (AQP6) MIP/aquaporin (TC 1.A.8) family Q13520
Syntaxin-1A (STX1A) Syntaxin family Q16623
Syntaxin-4 (STX4) Syntaxin family Q12846
Syntaxin-5 (STX5) Syntaxin family Q13190
Syntaxin-6 (STX6) Syntaxin family O43752
Transmembrane protein 106A (TMEM106A) TMEM106 family Q96A25
Transmembrane protein 106C (TMEM106C) TMEM106 family Q9BVX2
Transmembrane protein 205 (TMEM205) TMEM205 family Q6UW68
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-responsive element-binding protein 3-like protein 1 (CREB3L1) BZIP family Q96BA8
Paired-like homeodomain transcription factor LEUTX (LEUTX) Paired homeobox family A8MZ59
GPCR
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
G-protein coupled receptor 42 (GPR42) G-protein coupled receptor 1 family O15529
Probable G-protein coupled receptor 152 (GPR152) G-protein coupled receptor 1 family Q8TDT2
Other
Click To Hide/Show 14 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
BET1 homolog (BET1) BET1 family O15155
Bladder cancer-associated protein (BLCAP) BLCAP family P62952
Membrane protein FAM174A (FAM174A) FAM174 family Q8TBP5
Protein FAM209A (FAM209A) FAM209 family Q5JX71
. GOLGA8 family Q08AF8
Putative golgin subfamily A member 8D (GOLGA8DP) GOLGA8 family Q0D2H9
Protein jagunal homolog 1 (JAGN1) Jagunal family Q8N5M9
Reticulophagy regulator 3 (RETREG3) RETREG family Q86VR2
Transmembrane and coiled-coil domain-containing protein 5A (TMCO5A) TMCO5 family Q8N6Q1
Immediate early response 3-interacting protein 1 (IER3IP1) YOS1 family Q9Y5U9
Fetal and adult testis-expressed transcript protein (FATE1) . Q969F0
Lck-interacting transmembrane adapter 1 (LIME1) . Q9H400
Protein KASH5 (KASH5) . Q8N6L0
Sperm-associated antigen 4 protein (SPAG4) . Q9NPE6

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
13 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578