Details of the Target

General Information of Target

Target ID LDTP10398
Target Name Receptor expression-enhancing protein 6 (REEP6)
Gene Name REEP6
Gene ID 92840
Synonyms
C19orf32; DP1L1; Receptor expression-enhancing protein 6; Polyposis locus protein 1-like 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEVVEAAAAQLETLKFNGTDFGVGEGPAAPSPGSAPVPGTQPPLQSFEGSPDAGQTVEVK
PAGEQPLQPVLNAVAAGTPAPQPQPPAESPACGDCVTSPGAAEPARAPDSLETSDSDSDS
DSETDSDSSSSSSSSSSSSSSSSSSCISLPPVLSDGDDDLQIEKENKNFPLKTKDELLLN
ELPSVEELTIILPEDIELKPLGMVSSIIEQLVIIESMTNLPPVNEETVIFKSDRQAAGKI
FEIFGPVAHPFYVLRFNSSDHIESKGIKIKETMYFAPSMKDFTQYIFTEKLKQDKGSDAS
WKNDQEPPPEALDFSDDEKEKEAKQRKKSQIQGRKKLKSEFNEPGEDFTEVHQNWNAHSS
ASEHAKGYRNREFTRGFSRARYPRSCHGRPPPQHFYNSEHMVSQETSGFPSQRQNNPIMP
QYPFPLPVFDMHNFPLRPPPPPPPPPVNMGWATPNMAAHPLLNLPYSLPPPPPPPPLPPP
PSSGDSNSHFGPYY
Target Bioclass
Transporter and channel
Family
DP1 family
Subcellular location
Endoplasmic reticulum membrane
Function
Required for correct function and survival of retinal photoreceptors. Required for retinal development. In rod photoreceptors, facilitates stability and/or trafficking of guanylate cyclases and is required to maintain endoplasmic reticulum and mitochondrial homeostasis. May play a role in clathrin-coated intracellular vesicle trafficking of proteins from the endoplasmic reticulum to the retinal rod plasma membrane.
Uniprot ID
Q96HR9
Ensemble ID
ENST00000233596.8
HGNC ID
HGNC:30078

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
YN-1
 Probe Info  		100.00  LDD0444  [1]
AOyne
 Probe Info  		13.60  LDD0443  [2]
NAIA_5
 Probe Info  		C123(0.00); C117(0.00)  LDD2223  [3]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C094
 Probe Info  		29.86  LDD1785  [4]
C112
 Probe Info  		29.45  LDD1799  [4]
C134
 Probe Info  		21.71  LDD1816  [4]
C388
 Probe Info  		74.03  LDD2047  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 13 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Maspardin (SPG21) AB hydrolase superfamily Q9NZD8
Peroxisomal bifunctional enzyme (EHHADH) Enoyl-CoA hydratase/isomerase family; 3-hydroxyacyl-CoA dehydrogenase family Q08426
Transmembrane protein with metallophosphoesterase domain (TMPPE) LOC643853 family Q6ZT21
MYG1 exonuclease (MYG1) MYG1 family Q9HB07
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
Atypical kinase COQ8A, mitochondrial (COQ8A) ADCK protein kinase family Q8NI60
Tyrosine-protein phosphatase non-receptor type 9 (PTPN9) Protein-tyrosine phosphatase family P43378
Tensin-2 (TNS2) PTEN phosphatase protein family Q63HR2
17-beta-hydroxysteroid dehydrogenase 13 (HSD17B13) Short-chain dehydrogenases/reductases (SDR) family Q7Z5P4
Thioredoxin, mitochondrial (TXN2) Thioredoxin family Q99757
TLC domain-containing protein 4 (TLCD4) TLCD4 family Q96MV1
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Transmembrane ascorbate-dependent reductase CYB561 (CYB561) . P49447
Transporter and channel
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Proton-coupled zinc antiporter SLC30A8 (SLC30A8) Cation diffusion facilitator (CDF) transporter (TC 2.A.4) family Q8IWU4
Hsp90 co-chaperone Cdc37 (CDC37) CDC37 family Q16543
Gap junction alpha-8 protein (GJA8) Connexin family P48165
Endophilin-B1 (SH3GLB1) Endophilin family Q9Y371
ATP synthase-coupling factor 6, mitochondrial (ATP5PF) Eukaryotic ATPase subunit F6 family P18859
Sorting nexin-1 (SNX1) Sorting nexin family Q13596
Sorting nexin-11 (SNX11) Sorting nexin family Q9Y5W9
Sorting nexin-15 (SNX15) Sorting nexin family Q9NRS6
Sorting nexin-8 (SNX8) Sorting nexin family Q9Y5X2
Stimulator of interferon genes protein (STING1) STING family Q86WV6
Syntenin-1 (SDCBP) . O00560
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox-containing protein 1 (HMBOX1) . Q6NT76
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable G-protein coupled receptor 152 (GPR152) G-protein coupled receptor 1 family Q8TDT2
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
B-cell antigen receptor complex-associated protein alpha chain (CD79A) . P11912
Other
Click To Hide/Show 14 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ADP-ribosylation factor-like protein 6-interacting protein 1 (ARL6IP1) ARL6ip family Q15041
Lipopolysaccharide-induced tumor necrosis factor-alpha factor (LITAF) CDIP1/LITAF family Q99732
FHF complex subunit HOOK-interacting protein 1B (FHIP1B) FHIP family Q8N612
Cholecystokinin (CCK) Gastrin/cholecystokinin family P06307
Keratin-associated protein 3-1 (KRTAP3-1) KRTAP type 3 family Q9BYR8
Leptin receptor overlapping transcript-like 1 (LEPROTL1) OB-RGRP/VPS55 family O95214
Reticulophagy regulator 3 (RETREG3) RETREG family Q86VR2
Mitochondrial dynamics protein MIEF1 (MIEF1) SMCR7 family Q9NQG6
Synaptotagmin-16 (SYT16) Synaptotagmin family Q17RD7
PRKCA-binding protein (PICK1) . Q9NRD5
Protein TMED8 (TMED8) . Q6PL24
Receptor-binding cancer antigen expressed on SiSo cells (EBAG9) . O00559
Transmembrane protein 143 (TMEM143) . Q96AN5
Zinc finger FYVE domain-containing protein 21 (ZFYVE21) . Q9BQ24

References

1 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
2 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587