Details of the Target

General Information of Target

Target ID LDTP14716
Target Name ATP synthase subunit ATP5MJ, mitochondrial (ATP5MJ)
Gene Name ATP5MJ
Gene ID 9556
Synonyms
ATP5MPL; C14orf2; MP68; ATP synthase subunit ATP5MJ, mitochondrial; 6.8 kDa mitochondrial proteolipid protein; MLQ; ATP synthase membrane subunit 6.8PL
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPQKDPCQKQACEIQKCLQANSYMESKCQAVIQELRKCCAQYPKGRSVVCSGFEKEEEEN
LTRKSASK
Target Bioclass
Other
Family
Small mitochondrial proteolipid family
Subcellular location
Mitochondrion membrane
Function
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). Minor subunit required to maintain the ATP synthase population in the mitochondria.
Uniprot ID
P56378
Ensemble ID
ENST00000286953.8
HGNC ID
HGNC:1188

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 Deletion: p.Y21TfsTer6 .
MCC13 Substitution: p.P15F .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K14(5.26); K49(6.08)  LDD0277  [1]
Acrolein
 Probe Info  		N.A.  LDD0221  [2]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [2]
Methacrolein
 Probe Info  		N.A.  LDD0218  [2]
PAL-AfBPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C055
 Probe Info  		20.25  LDD1752  [3]
C056
 Probe Info  		33.59  LDD1753  [3]
C091
 Probe Info  		13.83  LDD1782  [3]
C092
 Probe Info  		25.46  LDD1783  [3]
C094
 Probe Info  		35.75  LDD1785  [3]
C106
 Probe Info  		18.90  LDD1793  [3]
C112
 Probe Info  		24.59  LDD1799  [3]
C210
 Probe Info  		59.71  LDD1884  [3]
C231
 Probe Info  		22.94  LDD1904  [3]
C232
 Probe Info  		46.85  LDD1905  [3]
C235
 Probe Info  		29.65  LDD1908  [3]
C285
 Probe Info  		20.68  LDD1955  [3]
C289
 Probe Info  		35.75  LDD1959  [3]
C293
 Probe Info  		18.00  LDD1963  [3]
C296
 Probe Info  		11.88  LDD1966  [3]
C314
 Probe Info  		16.00  LDD1981  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [2]
 LDCM0107  IAA HeLa N.A.  LDD0221  [2]
 LDCM0109  NEM HeLa N.A.  LDD0225  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Mitochondrial carrier homolog 2 (MTCH2) Mitochondrial carrier (TC 2.A.29) family Q9Y6C9
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Apolipoprotein C-I (APOC1) Apolipoprotein C1 family P02654
Lipid transferase CIDEB (CIDEB) CIDE family Q9UHD4

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587