Details of the Target

General Information of Target

Target ID LDTP00358
Target Name Succinate dehydrogenase cytochrome b small subunit, mitochondrial (SDHD)
Gene Name SDHD
Gene ID 6392
Synonyms
SDH4; Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial; CybS; CII-4; QPs3; Succinate dehydrogenase complex subunit D; Succinate-ubiquinone oxidoreductase cytochrome b small subunit; Succinate-ubiquinone reductase membrane anchor subunit
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAVLWRLSAVCGALGGRALLLRTPVVRPAHISAFLQDRPIPEWCGVQHIHLSPSHHSGSK
AASLHWTSERVVSVLLLGLLPAAYLNPCSAMDYSLAAALTLHGHWGLGQVVTDYVHGDAL
QKAAKAGLLALSALTFAGLCYFNYHDVGICKAVAMLWKL
Target Type
Literature-reported
Target Bioclass
Transporter and channel
Family
CybS family
Subcellular location
Mitochondrion inner membrane
Function
Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
TTD ID
T39811
Uniprot ID
O14521
DrugMap ID
TTVH9W8
Ensemble ID
ENST00000375549.8
HGNC ID
HGNC:10683

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO792 SNV: p.S94F .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
HPAP
 Probe Info  		4.28  LDD0062  [2]
DBIA
 Probe Info  		C140(1.11); C150(1.11)  LDD1492  [3]
5E-2FA
 Probe Info  		N.A.  LDD2235  [4]
TFBX
 Probe Info  		N.A.  LDD0027  [5]
Acrolein
 Probe Info  		N.A.  LDD0217  [6]
AOyne
 Probe Info  		15.00  LDD0443  [7]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C112
 Probe Info  		29.45  LDD1799  [8]
BD-F
 Probe Info  		N.A.  LDD0024  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C150(0.94)  LDD1508  [3]
 LDCM0277  AC18 HEK-293T C150(0.85)  LDD1516  [3]
 LDCM0279  AC2 HEK-293T C150(0.84)  LDD1518  [3]
 LDCM0286  AC26 HEK-293T C150(0.84)  LDD1525  [3]
 LDCM0295  AC34 HEK-293T C150(0.87)  LDD1534  [3]
 LDCM0304  AC42 HEK-293T C150(0.72)  LDD1543  [3]
 LDCM0313  AC50 HEK-293T C150(0.81)  LDD1552  [3]
 LDCM0321  AC58 HEK-293T C150(0.91)  LDD1560  [3]
 LDCM0108  Chloroacetamide HeLa H56(0.00); H55(0.00)  LDD0222  [6]
 LDCM0367  CL1 HEK-293T C150(1.04)  LDD1571  [3]
 LDCM0369  CL100 HEK-293T C150(0.91)  LDD1573  [3]
 LDCM0370  CL101 HEK-293T C150(0.97)  LDD1574  [3]
 LDCM0373  CL104 HEK-293T C150(1.15)  LDD1577  [3]
 LDCM0374  CL105 HEK-293T C150(1.10)  LDD1578  [3]
 LDCM0377  CL108 HEK-293T C150(0.97)  LDD1581  [3]
 LDCM0378  CL109 HEK-293T C150(0.98)  LDD1582  [3]
 LDCM0382  CL112 HEK-293T C150(1.12)  LDD1586  [3]
 LDCM0383  CL113 HEK-293T C150(1.03)  LDD1587  [3]
 LDCM0386  CL116 HEK-293T C150(1.02)  LDD1590  [3]
 LDCM0387  CL117 HEK-293T C150(1.03)  LDD1591  [3]
 LDCM0391  CL120 HEK-293T C150(0.98)  LDD1595  [3]
 LDCM0392  CL121 HEK-293T C150(1.01)  LDD1596  [3]
 LDCM0395  CL124 HEK-293T C150(0.96)  LDD1599  [3]
 LDCM0396  CL125 HEK-293T C150(1.08)  LDD1600  [3]
 LDCM0399  CL128 HEK-293T C150(1.01)  LDD1603  [3]
 LDCM0400  CL13 HEK-293T C150(0.85)  LDD1604  [3]
 LDCM0403  CL16 HEK-293T C150(0.94)  LDD1607  [3]
 LDCM0405  CL18 HEK-293T C150(0.87)  LDD1609  [3]
 LDCM0413  CL25 HEK-293T C150(0.79)  LDD1617  [3]
 LDCM0416  CL28 HEK-293T C150(1.07)  LDD1620  [3]
 LDCM0419  CL30 HEK-293T C150(0.80)  LDD1623  [3]
 LDCM0426  CL37 HEK-293T C150(0.86)  LDD1630  [3]
 LDCM0429  CL4 HEK-293T C150(1.01)  LDD1633  [3]
 LDCM0430  CL40 HEK-293T C150(1.28)  LDD1634  [3]
 LDCM0432  CL42 HEK-293T C150(0.78)  LDD1636  [3]
 LDCM0439  CL49 HEK-293T C150(0.98)  LDD1643  [3]
 LDCM0443  CL52 HEK-293T C150(1.17)  LDD1646  [3]
 LDCM0445  CL54 HEK-293T C150(1.14)  LDD1648  [3]
 LDCM0451  CL6 HEK-293T C150(0.95)  LDD1654  [3]
 LDCM0453  CL61 HEK-293T C150(0.87)  LDD1656  [3]
 LDCM0456  CL64 HEK-293T C150(0.93)  LDD1659  [3]
 LDCM0458  CL66 HEK-293T C150(0.79)  LDD1661  [3]
 LDCM0466  CL73 HEK-293T C150(0.91)  LDD1669  [3]
 LDCM0469  CL76 HEK-293T C150(1.16)  LDD1672  [3]
 LDCM0471  CL78 HEK-293T C150(0.92)  LDD1674  [3]
 LDCM0479  CL85 HEK-293T C150(1.09)  LDD1682  [3]
 LDCM0482  CL88 HEK-293T C150(0.80)  LDD1685  [3]
 LDCM0485  CL90 HEK-293T C150(0.93)  LDD1688  [3]
 LDCM0492  CL97 HEK-293T C150(0.82)  LDD1695  [3]
 LDCM0107  IAA HeLa N.A.  LDD0221  [6]
 LDCM0022  KB02 HEK-293T C140(1.11); C150(1.11)  LDD1492  [3]
 LDCM0023  KB03 HEK-293T C140(0.81); C150(0.81)  LDD1497  [3]
 LDCM0024  KB05 HEK-293T C140(0.93); C150(0.93)  LDD1502  [3]
 LDCM0109  NEM HeLa N.A.  LDD0226  [6]
 LDCM0014  Panhematin HEK-293T 4.28  LDD0062  [2]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Hexachlorophene Small molecular drug DB00756
Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
2-hexyloxy-6-hydroxymethyl-tetrahydro-pyran-345-triol . DB04141
Ubiquinone Q1 . DB08689

References

1 Labeling Preferences of Diazirines with Protein Biomolecules. J Am Chem Soc. 2021 May 5;143(17):6691-6700. doi: 10.1021/jacs.1c02509. Epub 2021 Apr 20.
Mass spectrometry data entry: PXD025140
2 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
4 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
9 Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.
Mass spectrometry data entry: PXD025652