Details of the Target

General Information of Target

Target ID LDTP06928
Target Name Coiled-coil domain-containing protein 93 (CCDC93)
Gene Name CCDC93
Gene ID 54520
Synonyms
Coiled-coil domain-containing protein 93
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGLPRGPEGQGLPEVETREDEEQNVKLTEILELLVAAGYFRARIKGLSPFDKVVGGMTWC
ITTCNFDVDVDLLFQENSTIGQKIALSEKIVSVLPRMKCPHQLEPHQIQGMDFIHIFPVV
QWLVKRAIETKEEMGDYIRSYSVSQFQKTYSLPEDDDFIKRKEKAIKTVVDLSEVYKPRR
KYKRHQGAEELLDEESRIHATLLEYGRRYGFSRQSKMEKAEDKKTALPAGLSATEKADAH
EEDELRAAEEQRIQSLMTKMTAMANEESRLTASSVGQIVGLCSAEIKQIVSEYAEKQSEL
SAEESPEKLGTSQLHRRKVISLNKQIAQKTKHLEELRASHTSLQARYNEAKKTLTELKTY
SEKLDKEQAALEKIESKADPSILQNLRALVAMNENLKSQEQEFKAHCREEMTRLQQEIEN
LKAERAPRGDEKTLSSGEPPGTLTSAMTHDEDLDRRYNMEKEKLYKIRLLQARRNREIAI
LHRKIDEVPSRAELIQYQKRFIELYRQISAVHKETKQFFTLYNTLDDKKVYLEKEISLLN
SIHENFSQAMASPAARDQFLRQMEQIVEGIKQSRMKMEKKKQENKMRRDQLNDQYLELLE
KQRLYFKTVKEFKEEGRKNEMLLSKVKAKAS
Target Bioclass
Transporter and channel
Family
CCDC93 family
Subcellular location
Early endosome
Function
Component of the CCC complex, which is involved in the regulation of endosomal recycling of surface proteins, including integrins, signaling receptor and channels. The CCC complex associates with SNX17, retriever and WASH complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGA5:ITGB1. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes and is dependent on its interaction with WASHC2C.; (Microbial infection) The CCC complex, in collaboration with the heterotrimeric retriever complex, mediates the exit of human papillomavirus to the cell surface.
Uniprot ID
Q567U6
Ensemble ID
ENST00000376300.7
HGNC ID
HGNC:25611

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K516(4.31); K607(3.39); K610(3.59); K625(2.77)  LDD0277  [1]
Probe 1
 Probe Info  		Y137(25.77); Y141(5.78)  LDD3495  [2]
AHL-Pu-1
 Probe Info  		C282(2.57)  LDD0170  [3]
Acrolein
 Probe Info  		N.A.  LDD0222  [4]
DBIA
 Probe Info  		C282(0.98)  LDD0532  [5]
m-APA
 Probe Info  		N.A.  LDD2231  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [8]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [7]
NAIA_5
 Probe Info  		N.A.  LDD2225  [9]
TFBX
 Probe Info  		N.A.  LDD0027  [10]
IPM
 Probe Info  		N.A.  LDD2156  [11]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C112
 Probe Info  		30.06  LDD1799  [12]
C187
 Probe Info  		48.50  LDD1865  [12]
C201
 Probe Info  		26.17  LDD1877  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C282(2.57)  LDD0170  [3]
 LDCM0026  4SU-RNA+native RNA DM93 C282(2.21)  LDD0171  [3]
 LDCM0214  AC1 PaTu 8988t C282(0.46)  LDD1093  [5]
 LDCM0215  AC10 HCT 116 C282(0.98)  LDD0532  [5]
 LDCM0216  AC100 HEK-293T C282(0.66)  LDD0814  [5]
 LDCM0217  AC101 HEK-293T C282(1.02)  LDD0815  [5]
 LDCM0218  AC102 HEK-293T C282(1.14)  LDD0816  [5]
 LDCM0219  AC103 HEK-293T C282(0.66)  LDD0817  [5]
 LDCM0220  AC104 HEK-293T C282(0.73)  LDD0818  [5]
 LDCM0221  AC105 HEK-293T C282(0.61)  LDD0819  [5]
 LDCM0222  AC106 HEK-293T C282(0.65)  LDD0820  [5]
 LDCM0223  AC107 HEK-293T C282(0.62)  LDD0821  [5]
 LDCM0224  AC108 HEK-293T C282(0.64)  LDD0822  [5]
 LDCM0225  AC109 HEK-293T C282(0.67)  LDD0823  [5]
 LDCM0226  AC11 HCT 116 C282(0.88)  LDD0543  [5]
 LDCM0227  AC110 HEK-293T C282(1.01)  LDD0825  [5]
 LDCM0228  AC111 HEK-293T C282(1.14)  LDD0826  [5]
 LDCM0229  AC112 HEK-293T C282(0.89)  LDD0827  [5]
 LDCM0230  AC113 HEK-293T C282(1.00)  LDD0828  [5]
 LDCM0231  AC114 HEK-293T C282(0.99)  LDD0829  [5]
 LDCM0232  AC115 HEK-293T C282(1.34)  LDD0830  [5]
 LDCM0233  AC116 HEK-293T C282(1.51)  LDD0831  [5]
 LDCM0234  AC117 HEK-293T C282(1.35)  LDD0832  [5]
 LDCM0235  AC118 HEK-293T C282(1.48)  LDD0833  [5]
 LDCM0236  AC119 HEK-293T C282(1.20)  LDD0834  [5]
 LDCM0237  AC12 HCT 116 C282(0.83)  LDD0554  [5]
 LDCM0238  AC120 HEK-293T C282(2.35)  LDD0836  [5]
 LDCM0239  AC121 HEK-293T C282(1.40)  LDD0837  [5]
 LDCM0240  AC122 HEK-293T C282(1.89)  LDD0838  [5]
 LDCM0241  AC123 HEK-293T C282(1.66)  LDD0839  [5]
 LDCM0242  AC124 HEK-293T C282(1.47)  LDD0840  [5]
 LDCM0243  AC125 HEK-293T C282(1.85)  LDD0841  [5]
 LDCM0244  AC126 HEK-293T C282(1.90)  LDD0842  [5]
 LDCM0245  AC127 HEK-293T C282(2.49)  LDD0843  [5]
 LDCM0259  AC14 HCT 116 C282(1.11)  LDD0576  [5]
 LDCM0270  AC15 HCT 116 C282(1.25)  LDD0587  [5]
 LDCM0276  AC17 HEK-293T C282(1.47)  LDD0874  [5]
 LDCM0277  AC18 HEK-293T C282(1.34)  LDD0875  [5]
 LDCM0278  AC19 HEK-293T C282(1.35)  LDD0876  [5]
 LDCM0279  AC2 PaTu 8988t C282(0.47)  LDD1158  [5]
 LDCM0280  AC20 HEK-293T C282(1.23)  LDD0878  [5]
 LDCM0281  AC21 HEK-293T C282(1.83)  LDD0879  [5]
 LDCM0282  AC22 HEK-293T C282(0.85)  LDD0880  [5]
 LDCM0283  AC23 HEK-293T C282(1.37)  LDD0881  [5]
 LDCM0284  AC24 HEK-293T C282(1.11)  LDD0882  [5]
 LDCM0285  AC25 PaTu 8988t C282(0.97)  LDD1164  [5]
 LDCM0286  AC26 PaTu 8988t C282(1.14)  LDD1165  [5]
 LDCM0287  AC27 PaTu 8988t C282(1.02)  LDD1166  [5]
 LDCM0288  AC28 PaTu 8988t C282(0.93)  LDD1167  [5]
 LDCM0289  AC29 PaTu 8988t C282(0.84)  LDD1168  [5]
 LDCM0290  AC3 PaTu 8988t C282(0.50)  LDD1169  [5]
 LDCM0291  AC30 PaTu 8988t C282(1.08)  LDD1170  [5]
 LDCM0292  AC31 PaTu 8988t C282(0.96)  LDD1171  [5]
 LDCM0293  AC32 PaTu 8988t C282(0.98)  LDD1172  [5]
 LDCM0294  AC33 PaTu 8988t C282(0.98)  LDD1173  [5]
 LDCM0295  AC34 PaTu 8988t C282(0.96)  LDD1174  [5]
 LDCM0296  AC35 HEK-293T C282(1.02); C99(1.07)  LDD1535  [13]
 LDCM0297  AC36 HEK-293T C282(1.24); C99(0.89)  LDD1536  [13]
 LDCM0298  AC37 HEK-293T C282(1.06); C99(1.11)  LDD1537  [13]
 LDCM0299  AC38 HEK-293T C99(1.19)  LDD1538  [13]
 LDCM0300  AC39 HEK-293T C282(0.96); C99(0.96)  LDD1539  [13]
 LDCM0301  AC4 PaTu 8988t C282(0.44)  LDD1180  [5]
 LDCM0302  AC40 HEK-293T C282(1.04); C99(0.98)  LDD1541  [13]
 LDCM0303  AC41 HEK-293T C282(1.14); C99(0.94)  LDD1542  [13]
 LDCM0304  AC42 HEK-293T C282(1.05); C99(1.10)  LDD1543  [13]
 LDCM0305  AC43 HEK-293T C282(0.95); C99(1.01)  LDD1544  [13]
 LDCM0306  AC44 HEK-293T C282(1.08); C99(1.00)  LDD1545  [13]
 LDCM0307  AC45 HEK-293T C282(1.11); C99(1.08)  LDD1546  [13]
 LDCM0308  AC46 HCT 116 C282(1.15)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C282(0.97)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C282(1.06)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C282(1.14)  LDD0628  [5]
 LDCM0312  AC5 PaTu 8988t C282(0.46)  LDD1191  [5]
 LDCM0313  AC50 HCT 116 C282(1.11)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C282(1.15)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C282(1.03)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C282(1.02)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C282(1.10)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C282(0.97)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C282(1.05)  LDD0636  [5]
 LDCM0320  AC57 HEK-293T C282(1.08); C99(1.02)  LDD1559  [13]
 LDCM0321  AC58 HEK-293T C282(1.01); C99(1.08)  LDD1560  [13]
 LDCM0322  AC59 HEK-293T C282(1.05); C99(1.24)  LDD1561  [13]
 LDCM0323  AC6 HCT 116 C282(1.04)  LDD0640  [5]
 LDCM0324  AC60 HEK-293T C282(1.22); C99(1.07)  LDD1563  [13]
 LDCM0325  AC61 HEK-293T C282(0.99); C99(1.10)  LDD1564  [13]
 LDCM0326  AC62 HEK-293T C99(1.08)  LDD1565  [13]
 LDCM0327  AC63 HEK-293T C282(0.92); C99(1.08)  LDD1566  [13]
 LDCM0328  AC64 HEK-293T C282(1.00); C99(1.11)  LDD1567  [13]
 LDCM0332  AC68 HEK-293T C282(0.75)  LDD0930  [5]
 LDCM0333  AC69 HEK-293T C282(1.02)  LDD0931  [5]
 LDCM0334  AC7 HCT 116 C282(1.01)  LDD0651  [5]
 LDCM0335  AC70 HEK-293T C282(0.66)  LDD0933  [5]
 LDCM0336  AC71 HEK-293T C282(1.01)  LDD0934  [5]
 LDCM0337  AC72 HEK-293T C282(0.88)  LDD0935  [5]
 LDCM0338  AC73 HEK-293T C282(1.12)  LDD0936  [5]
 LDCM0339  AC74 HEK-293T C282(1.07)  LDD0937  [5]
 LDCM0340  AC75 HEK-293T C282(0.60)  LDD0938  [5]
 LDCM0341  AC76 HEK-293T C282(0.64)  LDD0939  [5]
 LDCM0342  AC77 HEK-293T C282(0.65)  LDD0940  [5]
 LDCM0343  AC78 HEK-293T C282(0.80)  LDD0941  [5]
 LDCM0344  AC79 HEK-293T C282(0.66)  LDD0942  [5]
 LDCM0345  AC8 HCT 116 C282(1.03)  LDD0662  [5]
 LDCM0346  AC80 HEK-293T C282(0.68)  LDD0944  [5]
 LDCM0347  AC81 HEK-293T C282(0.64)  LDD0945  [5]
 LDCM0348  AC82 HEK-293T C282(0.76)  LDD0946  [5]
 LDCM0349  AC83 HEK-293T C282(1.30)  LDD0947  [5]
 LDCM0350  AC84 HEK-293T C282(1.15)  LDD0948  [5]
 LDCM0351  AC85 HEK-293T C282(1.07)  LDD0949  [5]
 LDCM0352  AC86 HEK-293T C282(1.45)  LDD0950  [5]
 LDCM0353  AC87 HEK-293T C282(1.39)  LDD0951  [5]
 LDCM0354  AC88 HEK-293T C282(2.07)  LDD0952  [5]
 LDCM0355  AC89 HEK-293T C282(2.48)  LDD0953  [5]
 LDCM0357  AC90 HEK-293T C282(1.65)  LDD0955  [5]
 LDCM0358  AC91 HEK-293T C282(1.58)  LDD0956  [5]
 LDCM0359  AC92 HEK-293T C282(1.57)  LDD0957  [5]
 LDCM0360  AC93 HEK-293T C282(1.83)  LDD0958  [5]
 LDCM0361  AC94 HEK-293T C282(1.62)  LDD0959  [5]
 LDCM0362  AC95 HEK-293T C282(1.65)  LDD0960  [5]
 LDCM0363  AC96 HEK-293T C282(1.83)  LDD0961  [5]
 LDCM0364  AC97 HEK-293T C282(2.81)  LDD0962  [5]
 LDCM0365  AC98 HEK-293T C282(0.79)  LDD0963  [5]
 LDCM0366  AC99 HEK-293T C282(0.66)  LDD0964  [5]
 LDCM0248  AKOS034007472 HCT 116 C282(0.97)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C282(0.86)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C282(1.27)  LDD0592  [5]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [4]
 LDCM0632  CL-Sc Hep-G2 C282(0.26)  LDD2227  [9]
 LDCM0367  CL1 PaTu 8988t C282(0.97)  LDD1246  [5]
 LDCM0368  CL10 PaTu 8988t C282(0.90)  LDD1247  [5]
 LDCM0369  CL100 PaTu 8988t C282(0.46)  LDD1248  [5]
 LDCM0370  CL101 HCT 116 C282(1.17)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C282(0.93)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C282(0.81)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C282(0.92)  LDD0690  [5]
 LDCM0374  CL105 HEK-293T C282(1.01)  LDD0972  [5]
 LDCM0375  CL106 HEK-293T C282(0.90)  LDD0973  [5]
 LDCM0376  CL107 HEK-293T C282(1.15)  LDD0974  [5]
 LDCM0377  CL108 HEK-293T C282(1.14)  LDD0975  [5]
 LDCM0378  CL109 HEK-293T C282(0.99)  LDD0976  [5]
 LDCM0379  CL11 PaTu 8988t C282(1.16)  LDD1258  [5]
 LDCM0380  CL110 HEK-293T C282(1.14)  LDD0978  [5]
 LDCM0381  CL111 HEK-293T C282(1.01)  LDD0979  [5]
 LDCM0382  CL112 PaTu 8988t C282(0.89)  LDD1261  [5]
 LDCM0383  CL113 PaTu 8988t C282(0.93)  LDD1262  [5]
 LDCM0384  CL114 PaTu 8988t C282(0.71)  LDD1263  [5]
 LDCM0385  CL115 PaTu 8988t C282(0.88)  LDD1264  [5]
 LDCM0386  CL116 PaTu 8988t C282(0.86)  LDD1265  [5]
 LDCM0387  CL117 HEK-293T C282(1.01); C99(1.12)  LDD1591  [13]
 LDCM0388  CL118 HEK-293T C282(1.12); C99(1.08)  LDD1592  [13]
 LDCM0389  CL119 HEK-293T C282(0.99); C99(1.07)  LDD1593  [13]
 LDCM0390  CL12 PaTu 8988t C282(1.12)  LDD1269  [5]
 LDCM0391  CL120 HEK-293T C282(1.03); C99(0.94)  LDD1595  [13]
 LDCM0392  CL121 HCT 116 C282(1.06)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C282(0.93)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C282(0.97)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C282(1.06)  LDD0712  [5]
 LDCM0396  CL125 HEK-293T C282(1.05); C99(1.11)  LDD1600  [13]
 LDCM0397  CL126 HEK-293T C282(1.01); C99(1.27)  LDD1601  [13]
 LDCM0398  CL127 HEK-293T C282(0.94); C99(1.12)  LDD1602  [13]
 LDCM0399  CL128 HEK-293T C282(1.02); C99(1.05)  LDD1603  [13]
 LDCM0400  CL13 PaTu 8988t C282(0.99)  LDD1279  [5]
 LDCM0401  CL14 PaTu 8988t C282(1.07)  LDD1280  [5]
 LDCM0402  CL15 PaTu 8988t C282(0.98)  LDD1281  [5]
 LDCM0403  CL16 PaTu 8988t C282(1.10)  LDD1282  [5]
 LDCM0404  CL17 PaTu 8988t C282(1.03)  LDD1283  [5]
 LDCM0405  CL18 PaTu 8988t C282(0.96)  LDD1284  [5]
 LDCM0406  CL19 PaTu 8988t C282(1.19)  LDD1285  [5]
 LDCM0407  CL2 PaTu 8988t C282(1.04)  LDD1286  [5]
 LDCM0408  CL20 PaTu 8988t C282(1.00)  LDD1287  [5]
 LDCM0409  CL21 PaTu 8988t C282(1.05)  LDD1288  [5]
 LDCM0410  CL22 PaTu 8988t C282(1.20)  LDD1289  [5]
 LDCM0411  CL23 PaTu 8988t C282(1.13)  LDD1290  [5]
 LDCM0412  CL24 PaTu 8988t C282(1.01)  LDD1291  [5]
 LDCM0413  CL25 PaTu 8988t C282(0.84)  LDD1292  [5]
 LDCM0414  CL26 PaTu 8988t C282(1.05)  LDD1293  [5]
 LDCM0415  CL27 PaTu 8988t C282(0.96)  LDD1294  [5]
 LDCM0416  CL28 PaTu 8988t C282(1.10)  LDD1295  [5]
 LDCM0417  CL29 PaTu 8988t C282(1.24)  LDD1296  [5]
 LDCM0418  CL3 PaTu 8988t C282(0.96)  LDD1297  [5]
 LDCM0419  CL30 PaTu 8988t C282(0.97)  LDD1298  [5]
 LDCM0420  CL31 HCT 116 C282(1.03)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C282(0.98)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C282(0.90)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C282(0.80)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C282(1.51)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C282(1.16)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C282(1.15)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C282(1.06)  LDD0745  [5]
 LDCM0429  CL4 PaTu 8988t C282(1.02)  LDD1308  [5]
 LDCM0430  CL40 HCT 116 C282(1.05)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C282(1.02)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C282(1.03)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C282(0.97)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C282(0.92)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C282(0.90)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C282(0.77)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C282(0.83)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C282(0.85)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C282(0.57)  LDD0756  [5]
 LDCM0440  CL5 PaTu 8988t C282(0.98)  LDD1319  [5]
 LDCM0441  CL50 HCT 116 C282(0.91)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C282(0.82)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C282(0.86)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C282(0.98)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C282(0.80)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C282(0.87)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C282(0.95)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C282(1.18)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C282(0.83)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C282(0.85)  LDD0767  [5]
 LDCM0451  CL6 PaTu 8988t C282(1.01)  LDD1330  [5]
 LDCM0452  CL60 HCT 116 C282(0.70)  LDD0769  [5]
 LDCM0453  CL61 PaTu 8988t C282(1.15)  LDD1332  [5]
 LDCM0454  CL62 PaTu 8988t C282(1.07)  LDD1333  [5]
 LDCM0455  CL63 PaTu 8988t C282(0.94)  LDD1334  [5]
 LDCM0456  CL64 PaTu 8988t C282(1.02)  LDD1335  [5]
 LDCM0457  CL65 PaTu 8988t C282(1.04)  LDD1336  [5]
 LDCM0458  CL66 PaTu 8988t C282(1.26)  LDD1337  [5]
 LDCM0459  CL67 PaTu 8988t C282(0.97)  LDD1338  [5]
 LDCM0460  CL68 PaTu 8988t C282(1.12)  LDD1339  [5]
 LDCM0461  CL69 PaTu 8988t C282(1.08)  LDD1340  [5]
 LDCM0462  CL7 PaTu 8988t C282(1.17)  LDD1341  [5]
 LDCM0463  CL70 PaTu 8988t C282(1.03)  LDD1342  [5]
 LDCM0464  CL71 PaTu 8988t C282(0.99)  LDD1343  [5]
 LDCM0465  CL72 PaTu 8988t C282(1.15)  LDD1344  [5]
 LDCM0466  CL73 PaTu 8988t C282(1.05)  LDD1345  [5]
 LDCM0467  CL74 PaTu 8988t C282(1.13)  LDD1346  [5]
 LDCM0469  CL76 PaTu 8988t C282(1.15)  LDD1348  [5]
 LDCM0470  CL77 PaTu 8988t C282(1.04)  LDD1349  [5]
 LDCM0471  CL78 PaTu 8988t C282(1.11)  LDD1350  [5]
 LDCM0472  CL79 PaTu 8988t C282(1.32)  LDD1351  [5]
 LDCM0473  CL8 PaTu 8988t C282(1.11)  LDD1352  [5]
 LDCM0474  CL80 PaTu 8988t C282(1.34)  LDD1353  [5]
 LDCM0475  CL81 PaTu 8988t C282(1.25)  LDD1354  [5]
 LDCM0476  CL82 PaTu 8988t C282(1.08)  LDD1355  [5]
 LDCM0477  CL83 PaTu 8988t C282(1.11)  LDD1356  [5]
 LDCM0478  CL84 PaTu 8988t C282(1.19)  LDD1357  [5]
 LDCM0479  CL85 PaTu 8988t C282(1.18)  LDD1358  [5]
 LDCM0480  CL86 PaTu 8988t C282(1.13)  LDD1359  [5]
 LDCM0481  CL87 PaTu 8988t C282(1.28)  LDD1360  [5]
 LDCM0482  CL88 PaTu 8988t C282(1.17)  LDD1361  [5]
 LDCM0483  CL89 PaTu 8988t C282(1.17)  LDD1362  [5]
 LDCM0484  CL9 PaTu 8988t C282(1.04)  LDD1363  [5]
 LDCM0485  CL90 PaTu 8988t C282(1.25)  LDD1364  [5]
 LDCM0486  CL91 PaTu 8988t C282(0.44)  LDD1365  [5]
 LDCM0487  CL92 PaTu 8988t C282(0.47)  LDD1366  [5]
 LDCM0488  CL93 PaTu 8988t C282(0.43)  LDD1367  [5]
 LDCM0489  CL94 PaTu 8988t C282(0.47)  LDD1368  [5]
 LDCM0490  CL95 PaTu 8988t C282(0.49)  LDD1369  [5]
 LDCM0491  CL96 PaTu 8988t C282(0.46)  LDD1370  [5]
 LDCM0492  CL97 PaTu 8988t C282(0.45)  LDD1371  [5]
 LDCM0493  CL98 PaTu 8988t C282(0.48)  LDD1372  [5]
 LDCM0494  CL99 PaTu 8988t C282(0.45)  LDD1373  [5]
 LDCM0495  E2913 HEK-293T C282(0.92); C99(1.11)  LDD1698  [13]
 LDCM0468  Fragment33 PaTu 8988t C282(1.15)  LDD1347  [5]
 LDCM0427  Fragment51 HCT 116 C282(1.32)  LDD0744  [5]
 LDCM0022  KB02 HEK-293T C282(0.88); C99(0.98)  LDD1492  [13]
 LDCM0023  KB03 HEK-293T C282(1.00); C99(1.02)  LDD1497  [13]
 LDCM0024  KB05 MKN-1 C282(2.11)  LDD3331  [14]
 LDCM0109  NEM HeLa N.A.  LDD0224  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Coiled-coil domain-containing protein 22 (CCDC22) CCDC22 family O60826
WASH complex subunit 2A (WASHC2A) FAM21 family Q641Q2
Other
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
COMM domain-containing protein 1 (COMMD1) . Q8N668
COMM domain-containing protein 10 (COMMD10) . Q9Y6G5
COMM domain-containing protein 2 (COMMD2) . Q86X83
COMM domain-containing protein 3 (COMMD3) . Q9UBI1
COMM domain-containing protein 4 (COMMD4) . Q9H0A8
COMM domain-containing protein 5 (COMMD5) . Q9GZQ3
COMM domain-containing protein 6 (COMMD6) . Q7Z4G1
COMM domain-containing protein 8 (COMMD8) . Q9NX08
COMM domain-containing protein 9 (COMMD9) . Q9P000

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
12 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840