Details of the Target

General Information of Target

Target ID LDTP01198
Target Name Nuclear receptor corepressor 1 (NCOR1)
Gene Name NCOR1
Gene ID 9611
Synonyms
KIAA1047; Nuclear receptor corepressor 1; N-CoR; N-CoR1
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSSSGYPPNQGAFSTEQSRYPPHSVQYTFPNTRHQQEFAVPDYRSSHLEVSQASQLLQQQ
QQQQLRRRPSLLSEFHPGSDRPQERRTSYEPFHPGPSPVDHDSLESKRPRLEQVSDSHFQ
RVSAAVLPLVHPLPEGLRASADAKKDPAFGGKHEAPSSPISGQPCGDDQNASPSKLSKEE
LIQSMDRVDREIAKVEQQILKLKKKQQQLEEEAAKPPEPEKPVSPPPVEQKHRSIVQIIY
DENRKKAEEAHKIFEGLGPKVELPLYNQPSDTKVYHENIKTNQVMRKKLILFFKRRNHAR
KQREQKICQRYDQLMEAWEKKVDRIENNPRRKAKESKTREYYEKQFPEIRKQREQQERFQ
RVGQRGAGLSATIARSEHEISEIIDGLSEQENNEKQMRQLSVIPPMMFDAEQRRVKFINM
NGLMEDPMKVYKDRQFMNVWTDHEKEIFKDKFIQHPKNFGLIASYLERKSVPDCVLYYYL
TKKNENYKALVRRNYGKRRGRNQQIARPSQEEKVEEKEEDKAEKTEKKEEEKKDEEEKDE
KEDSKENTKEKDKIDGTAEETEEREQATPRGRKTANSQGRRKGRITRSMTNEAAAASAAA
AAATEEPPPPLPPPPEPISTEPVETSRWTEEEMEVAKKGLVEHGRNWAAIAKMVGTKSEA
QCKNFYFNYKRRHNLDNLLQQHKQKTSRKPREERDVSQCESVASTVSAQEDEDIEASNEE
ENPEDSEVEAVKPSEDSPENATSRGNTEPAVELEPTTETAPSTSPSLAVPSTKPAEDESV
ETQVNDSISAETAEQMDVDQQEHSAEEGSVCDPPPATKADSVDVEVRVPENHASKVEGDN
TKERDLDRASEKVEPRDEDLVVAQQINAQRPEPQSDNDSSATCSADEDVDGEPERQRMFP
MDSKPSLLNPTGSILVSSPLKPNPLDLPQLQHRAAVIPPMVSCTPCNIPIGTPVSGYALY
QRHIKAMHESALLEEQRQRQEQIDLECRSSTSPCGTSKSPNREWEVLQPAPHQVITNLPE
GVRLPTTRPTRPPPPLIPSSKTTVASEKPSFIMGGSISQGTPGTYLTSHNQASYTQETPK
PSVGSISLGLPRQQESAKSATLPYIKQEEFSPRSQNSQPEGLLVRAQHEGVVRGTAGAIQ
EGSITRGTPTSKISVESIPSLRGSITQGTPALPQTGIPTEALVKGSISRMPIEDSSPEKG
REEAASKGHVIYEGKSGHILSYDNIKNAREGTRSPRTAHEISLKRSYESVEGNIKQGMSM
RESPVSAPLEGLICRALPRGSPHSDLKERTVLSGSIMQGTPRATTESFEDGLKYPKQIKR
ESPPIRAFEGAITKGKPYDGITTIKEMGRSIHEIPRQDILTQESRKTPEVVQSTRPIIEG
SISQGTPIKFDNNSGQSAIKHNVKSLITGPSKLSRGMPPLEIVPENIKVVERGKYEDVKA
GETVRSRHTSVVSSGPSVLRSTLHEAPKAQLSPGIYDDTSARRTPVSYQNTMSRGSPMMN
RTSDVTISSNKSTNHERKSTLTPTQRESIPAKSPVPGVDPVVSHSPFDPHHRGSTAGEVY
RSHLPTHLDPAMPFHRALDPAAAAYLFQRQLSPTPGYPSQYQLYAMENTRQTILNDYITS
QQMQVNLRPDVARGLSPREQPLGLPYPATRGIIDLTNMPPTILVPHPGGTSTPPMDRITY
IPGTQITFPPRPYNSASMSPGHPTHLAAAASAEREREREREKERERERIAAASSDLYLRP
GSEQPGRPGSHGYVRSPSPSVRTQETMLQQRPSVFQGTNGTSVITPLDPTAQLRIMPLPA
GGPSISQGLPASRYNTAADALAALVDAAASAPQMDVSKTKESKHEAARLEENLRSRSAAV
SEQQQLEQKTLEVEKRSVQCLYTSSAFPSGKPQPHSSVVYSEAGKDKGPPPKSRYEEELR
TRGKTTITAANFIDVIITRQIASDKDARERGSQSSDSSSSLSSHRYETPSDAIEVISPAS
SPAPPQEKLQTYQPEVVKANQAENDPTRQYEGPLHHYRPQQESPSPQQQLPPSSQAEGMG
QVPRTHRLITLADHICQIITQDFARNQVSSQTPQQPPTSTFQNSPSALVSTPVRTKTSNR
YSPESQAQSVHHQRPGSRVSPENLVDKSRGSRPGKSPERSHVSSEPYEPISPPQVPVVHE
KQDSLLLLSQRGAEPAEQRNDARSPGSISYLPSFFTKLENTSPMVKSKKQEIFRKLNSSG
GGDSDMAAAQPGTEIFNLPAVTTSGSVSSRGHSFADPASNLGLEDIIRKALMGSFDDKVE
DHGVVMSQPMGVVPGTANTSVVTSGETRREEGDPSPHSGGVCKPKLISKSNSRKSKSPIP
GQGYLGTERPSSVSSVHSEGDYHRQTPGWAWEDRPSSTGSTQFPYNPLTMRMLSSTPPTP
IACAPSAVNQAAPHQQNRIWEREPAPLLSAQYETLSDSDD
Target Bioclass
Transcription factor
Family
N-CoR nuclear receptor corepressors family
Subcellular location
Nucleus
Function
Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation. Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression. The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver.
Uniprot ID
O75376
Ensemble ID
ENST00000268712.8
HGNC ID
HGNC:7672
ChEMBL ID
CHEMBL3038484

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL51 SNV: p.P1536S .
COLO678 SNV: p.A214G .
DETROIT562 Insertion: p.P1149_T1150insALWEAEAGRSQGTer; p.T1150_S1151insILAN .
HCT116 Deletion: p.V822GfsTer3
SNV: p.V889M;p.V1444A		 .
HCT15 SNV: p.D786G; p.P945S .
HEC1B SNV: p.Y1314Ter .
HGC27 SNV: p.F293I DBIA    Probe Info 
HT115 SNV: p.R498H .
HUH28 SNV: p.S1962C .
IGROV1 SNV: p.P132Q .
JHH4 SNV: p.D2126N .
JHH7 SNV: p.T1670S .
LOXIMVI SNV: p.R2118S .
MEWO Substitution: p.P813F .
MFE319 SNV: p.G1084R .
NALM6 Deletion: p.G1385AfsTer4 DBIA    Probe Info 
NCIH1155 SNV: p.C1274Y DBIA    Probe Info 
NCIH1793 SNV: p.K203R; p.V1935L DBIA    Probe Info 
NCIH716 SNV: p.Q566K .
OAW42 SNV: p.R244W .
OPM2 SNV: p.Q356E .
RKO Deletion: p.Q1833RfsTer17
Insertion: p.T525NfsTer11
SNV: p.P2133S		 .
SKMM2 SNV: p.P1665T .
SNU1 Deletion: p.E529KfsTer26 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 25 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
TH211
 Probe Info  		Y1646(6.00)  LDD0257  [2]
Probe 1
 Probe Info  		Y487(96.51); Y1604(6.24); Y1915(25.65)  LDD3495  [3]
AHL-Pu-1
 Probe Info  		C987(10.00); C2403(2.16); C943(2.00)  LDD0170  [4]
HHS-475
 Probe Info  		Y465(0.84); Y1212(1.04)  LDD0264  [5]
Acrolein
 Probe Info  		H131(0.00); H1448(0.00)  LDD0227  [6]
DBIA
 Probe Info  		C994(1.21)  LDD0078  [7]
ATP probe
 Probe Info  		K457(0.00); K482(0.00); K483(0.00)  LDD0199  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		C474(0.00); C2322(0.00)  LDD0038  [9]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [9]
Lodoacetamide azide
 Probe Info  		C474(0.00); C2056(0.00)  LDD0037  [9]
IPM
 Probe Info  		N.A.  LDD0025  [10]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [10]
NAIA_4
 Probe Info  		C1274(0.00); C2056(0.00)  LDD2226  [11]
NAIA_5
 Probe Info  		C2056(0.00); C2322(0.00)  LDD2224  [11]
TFBX
 Probe Info  		C1274(0.00); C2403(0.00)  LDD0027  [10]
Compound 10
 Probe Info  		N.A.  LDD2216  [12]
Compound 11
 Probe Info  		C1274(0.00); C2056(0.00)  LDD2213  [12]
SF
 Probe Info  		N.A.  LDD0028  [13]
VSF
 Probe Info  		N.A.  LDD0007  [14]
Phosphinate-6
 Probe Info  		C2403(0.00); C2056(0.00); C2322(0.00); C1274(0.00)  LDD0018  [15]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [6]
Methacrolein
 Probe Info  		N.A.  LDD0218  [6]
AOyne
 Probe Info  		12.50  LDD0443  [16]
HHS-465
 Probe Info  		N.A.  LDD2240  [17]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C112
 Probe Info  		33.13  LDD1799  [18]
C403
 Probe Info  		16.11  LDD2061  [18]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C987(10.00); C2403(2.16); C943(2.00)  LDD0170  [4]
 LDCM0026  4SU-RNA+native RNA DM93 C987(7.05)  LDD0171  [4]
 LDCM0214  AC1 PaTu 8988t C474(1.46)  LDD1093  [7]
 LDCM0215  AC10 PaTu 8988t C474(1.12)  LDD1094  [7]
 LDCM0216  AC100 PaTu 8988t C474(0.97)  LDD1095  [7]
 LDCM0217  AC101 PaTu 8988t C474(0.81)  LDD1096  [7]
 LDCM0218  AC102 PaTu 8988t C474(0.92)  LDD1097  [7]
 LDCM0219  AC103 PaTu 8988t C474(0.80)  LDD1098  [7]
 LDCM0220  AC104 PaTu 8988t C474(0.81)  LDD1099  [7]
 LDCM0221  AC105 PaTu 8988t C474(0.80)  LDD1100  [7]
 LDCM0222  AC106 PaTu 8988t C474(0.82)  LDD1101  [7]
 LDCM0223  AC107 PaTu 8988t C474(0.79)  LDD1102  [7]
 LDCM0224  AC108 PaTu 8988t C474(1.12)  LDD1103  [7]
 LDCM0225  AC109 PaTu 8988t C474(1.38)  LDD1104  [7]
 LDCM0226  AC11 PaTu 8988t C474(0.93)  LDD1105  [7]
 LDCM0227  AC110 PaTu 8988t C474(1.39)  LDD1106  [7]
 LDCM0228  AC111 PaTu 8988t C474(1.21)  LDD1107  [7]
 LDCM0229  AC112 PaTu 8988t C474(0.94)  LDD1108  [7]
 LDCM0230  AC113 HEK-293T C987(1.14)  LDD0828  [7]
 LDCM0231  AC114 HEK-293T C987(1.09)  LDD0829  [7]
 LDCM0232  AC115 HEK-293T C987(1.16)  LDD0830  [7]
 LDCM0233  AC116 HEK-293T C987(1.03)  LDD0831  [7]
 LDCM0234  AC117 HEK-293T C987(1.14)  LDD0832  [7]
 LDCM0235  AC118 HEK-293T C987(1.27)  LDD0833  [7]
 LDCM0236  AC119 HEK-293T C987(1.16)  LDD0834  [7]
 LDCM0237  AC12 PaTu 8988t C474(1.08)  LDD1116  [7]
 LDCM0238  AC120 HEK-293T C987(1.26)  LDD0836  [7]
 LDCM0239  AC121 HEK-293T C987(1.15)  LDD0837  [7]
 LDCM0240  AC122 HEK-293T C987(1.06)  LDD0838  [7]
 LDCM0241  AC123 HEK-293T C987(1.15)  LDD0839  [7]
 LDCM0242  AC124 HEK-293T C987(1.11)  LDD0840  [7]
 LDCM0243  AC125 HEK-293T C987(1.25)  LDD0841  [7]
 LDCM0244  AC126 HEK-293T C987(1.27)  LDD0842  [7]
 LDCM0245  AC127 HEK-293T C987(1.46)  LDD0843  [7]
 LDCM0246  AC128 PaTu 8988t C474(0.95)  LDD1125  [7]
 LDCM0247  AC129 PaTu 8988t C474(1.20)  LDD1126  [7]
 LDCM0249  AC130 PaTu 8988t C474(1.36)  LDD1128  [7]
 LDCM0250  AC131 PaTu 8988t C474(1.16)  LDD1129  [7]
 LDCM0251  AC132 PaTu 8988t C474(1.35)  LDD1130  [7]
 LDCM0252  AC133 PaTu 8988t C474(1.30)  LDD1131  [7]
 LDCM0253  AC134 PaTu 8988t C474(1.32)  LDD1132  [7]
 LDCM0254  AC135 PaTu 8988t C474(1.49)  LDD1133  [7]
 LDCM0255  AC136 PaTu 8988t C474(1.01)  LDD1134  [7]
 LDCM0256  AC137 PaTu 8988t C474(1.09)  LDD1135  [7]
 LDCM0257  AC138 PaTu 8988t C474(1.43)  LDD1136  [7]
 LDCM0258  AC139 PaTu 8988t C474(1.08)  LDD1137  [7]
 LDCM0259  AC14 PaTu 8988t C474(0.84)  LDD1138  [7]
 LDCM0260  AC140 PaTu 8988t C474(1.52)  LDD1139  [7]
 LDCM0261  AC141 PaTu 8988t C474(1.39)  LDD1140  [7]
 LDCM0262  AC142 PaTu 8988t C474(1.48)  LDD1141  [7]
 LDCM0270  AC15 PaTu 8988t C474(0.82)  LDD1149  [7]
 LDCM0276  AC17 HEK-293T C987(1.26)  LDD0874  [7]
 LDCM0277  AC18 HEK-293T C987(1.09)  LDD0875  [7]
 LDCM0278  AC19 HEK-293T C987(1.32)  LDD0876  [7]
 LDCM0279  AC2 PaTu 8988t C474(1.16)  LDD1158  [7]
 LDCM0280  AC20 HEK-293T C987(1.22)  LDD0878  [7]
 LDCM0281  AC21 HEK-293T C987(1.27)  LDD0879  [7]
 LDCM0282  AC22 HEK-293T C987(1.17)  LDD0880  [7]
 LDCM0283  AC23 HEK-293T C987(1.19)  LDD0881  [7]
 LDCM0284  AC24 HEK-293T C987(1.16)  LDD0882  [7]
 LDCM0285  AC25 PaTu 8988t C474(0.79)  LDD1164  [7]
 LDCM0286  AC26 PaTu 8988t C474(1.00)  LDD1165  [7]
 LDCM0287  AC27 PaTu 8988t C474(0.92)  LDD1166  [7]
 LDCM0288  AC28 PaTu 8988t C474(1.06)  LDD1167  [7]
 LDCM0289  AC29 PaTu 8988t C474(1.07)  LDD1168  [7]
 LDCM0290  AC3 PaTu 8988t C474(1.26)  LDD1169  [7]
 LDCM0291  AC30 PaTu 8988t C474(0.95)  LDD1170  [7]
 LDCM0292  AC31 PaTu 8988t C474(0.96)  LDD1171  [7]
 LDCM0293  AC32 PaTu 8988t C474(1.50)  LDD1172  [7]
 LDCM0294  AC33 PaTu 8988t C474(1.10)  LDD1173  [7]
 LDCM0295  AC34 PaTu 8988t C474(1.17)  LDD1174  [7]
 LDCM0296  AC35 PaTu 8988t C474(1.17)  LDD1175  [7]
 LDCM0297  AC36 PaTu 8988t C474(1.08)  LDD1176  [7]
 LDCM0298  AC37 PaTu 8988t C474(0.87)  LDD1177  [7]
 LDCM0299  AC38 PaTu 8988t C474(0.95)  LDD1178  [7]
 LDCM0300  AC39 PaTu 8988t C474(1.12)  LDD1179  [7]
 LDCM0301  AC4 PaTu 8988t C474(1.19)  LDD1180  [7]
 LDCM0302  AC40 PaTu 8988t C474(1.31)  LDD1181  [7]
 LDCM0303  AC41 PaTu 8988t C474(1.08)  LDD1182  [7]
 LDCM0304  AC42 PaTu 8988t C474(1.25)  LDD1183  [7]
 LDCM0305  AC43 PaTu 8988t C474(1.16)  LDD1184  [7]
 LDCM0306  AC44 PaTu 8988t C474(1.17)  LDD1185  [7]
 LDCM0307  AC45 PaTu 8988t C474(1.03)  LDD1186  [7]
 LDCM0308  AC46 PaTu 8988t C474(0.76)  LDD1187  [7]
 LDCM0309  AC47 PaTu 8988t C474(0.68)  LDD1188  [7]
 LDCM0310  AC48 PaTu 8988t C474(0.70)  LDD1189  [7]
 LDCM0311  AC49 PaTu 8988t C474(0.77)  LDD1190  [7]
 LDCM0312  AC5 PaTu 8988t C474(1.53)  LDD1191  [7]
 LDCM0313  AC50 PaTu 8988t C474(0.76)  LDD1192  [7]
 LDCM0314  AC51 PaTu 8988t C474(0.96)  LDD1193  [7]
 LDCM0315  AC52 PaTu 8988t C474(0.81)  LDD1194  [7]
 LDCM0316  AC53 PaTu 8988t C474(0.83)  LDD1195  [7]
 LDCM0317  AC54 PaTu 8988t C474(0.98)  LDD1196  [7]
 LDCM0318  AC55 PaTu 8988t C474(0.92)  LDD1197  [7]
 LDCM0319  AC56 PaTu 8988t C474(0.86)  LDD1198  [7]
 LDCM0320  AC57 HEK-293T C987(1.31)  LDD0918  [7]
 LDCM0321  AC58 HEK-293T C987(0.97)  LDD0919  [7]
 LDCM0322  AC59 HEK-293T C987(1.05)  LDD0920  [7]
 LDCM0323  AC6 PaTu 8988t C474(1.15)  LDD1202  [7]
 LDCM0324  AC60 HEK-293T C987(0.84)  LDD0922  [7]
 LDCM0325  AC61 HEK-293T C987(1.25)  LDD0923  [7]
 LDCM0326  AC62 HEK-293T C987(1.01)  LDD0924  [7]
 LDCM0327  AC63 HEK-293T C987(1.11)  LDD0925  [7]
 LDCM0328  AC64 HEK-293T C987(0.98)  LDD0926  [7]
 LDCM0329  AC65 HEK-293T C987(1.21)  LDD0927  [7]
 LDCM0330  AC66 HEK-293T C987(1.02)  LDD0928  [7]
 LDCM0331  AC67 HEK-293T C987(1.06)  LDD0929  [7]
 LDCM0334  AC7 PaTu 8988t C474(1.09)  LDD1213  [7]
 LDCM0345  AC8 PaTu 8988t C474(0.94)  LDD1224  [7]
 LDCM0349  AC83 PaTu 8988t C474(0.88)  LDD1228  [7]
 LDCM0350  AC84 PaTu 8988t C474(1.00)  LDD1229  [7]
 LDCM0351  AC85 PaTu 8988t C474(0.99)  LDD1230  [7]
 LDCM0352  AC86 PaTu 8988t C474(0.97)  LDD1231  [7]
 LDCM0353  AC87 PaTu 8988t C474(0.92)  LDD1232  [7]
 LDCM0354  AC88 PaTu 8988t C474(0.88)  LDD1233  [7]
 LDCM0355  AC89 PaTu 8988t C474(0.94)  LDD1234  [7]
 LDCM0357  AC90 PaTu 8988t C474(0.97)  LDD1236  [7]
 LDCM0358  AC91 PaTu 8988t C474(1.42)  LDD1237  [7]
 LDCM0359  AC92 PaTu 8988t C474(1.05)  LDD1238  [7]
 LDCM0360  AC93 PaTu 8988t C474(1.15)  LDD1239  [7]
 LDCM0361  AC94 PaTu 8988t C474(1.55)  LDD1240  [7]
 LDCM0362  AC95 PaTu 8988t C474(1.28)  LDD1241  [7]
 LDCM0363  AC96 PaTu 8988t C474(0.96)  LDD1242  [7]
 LDCM0364  AC97 PaTu 8988t C474(1.36)  LDD1243  [7]
 LDCM0365  AC98 PaTu 8988t C474(1.04)  LDD1244  [7]
 LDCM0366  AC99 PaTu 8988t C474(1.01)  LDD1245  [7]
 LDCM0248  AKOS034007472 PaTu 8988t C474(1.02)  LDD1127  [7]
 LDCM0356  AKOS034007680 PaTu 8988t C474(0.98)  LDD1235  [7]
 LDCM0275  AKOS034007705 PaTu 8988t C474(0.89)  LDD1154  [7]
 LDCM0156  Aniline NCI-H1299 11.92  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C994(1.21)  LDD0078  [7]
 LDCM0632  CL-Sc Hep-G2 C2322(0.51)  LDD2227  [11]
 LDCM0367  CL1 HEK-293T C2322(0.84); C1274(0.88); C474(0.99); C2403(0.83)  LDD1571  [19]
 LDCM0368  CL10 HEK-293T C2322(1.13); C1274(0.88); C474(1.07); C2403(1.15)  LDD1572  [19]
 LDCM0369  CL100 PaTu 8988t C474(1.30)  LDD1248  [7]
 LDCM0370  CL101 PaTu 8988t C474(1.07)  LDD1249  [7]
 LDCM0371  CL102 PaTu 8988t C474(1.07)  LDD1250  [7]
 LDCM0372  CL103 PaTu 8988t C474(1.00)  LDD1251  [7]
 LDCM0373  CL104 PaTu 8988t C474(1.16)  LDD1252  [7]
 LDCM0374  CL105 HEK-293T C987(1.07)  LDD0972  [7]
 LDCM0375  CL106 HEK-293T C987(0.99)  LDD0973  [7]
 LDCM0376  CL107 HEK-293T C987(0.94)  LDD0974  [7]
 LDCM0377  CL108 HEK-293T C987(1.33)  LDD0975  [7]
 LDCM0378  CL109 HEK-293T C987(1.15)  LDD0976  [7]
 LDCM0379  CL11 HEK-293T C2322(0.54); C1274(1.01); C474(1.13); C2403(0.96)  LDD1583  [19]
 LDCM0380  CL110 HEK-293T C987(1.14)  LDD0978  [7]
 LDCM0381  CL111 HEK-293T C987(0.92)  LDD0979  [7]
 LDCM0382  CL112 PaTu 8988t C474(0.87)  LDD1261  [7]
 LDCM0383  CL113 PaTu 8988t C474(0.97)  LDD1262  [7]
 LDCM0384  CL114 PaTu 8988t C474(1.19)  LDD1263  [7]
 LDCM0385  CL115 PaTu 8988t C474(1.06)  LDD1264  [7]
 LDCM0386  CL116 PaTu 8988t C474(1.43)  LDD1265  [7]
 LDCM0387  CL117 PaTu 8988t C474(1.21)  LDD1266  [7]
 LDCM0388  CL118 PaTu 8988t C474(1.68)  LDD1267  [7]
 LDCM0389  CL119 PaTu 8988t C474(1.25)  LDD1268  [7]
 LDCM0390  CL12 HEK-293T C2322(1.45); C1274(1.02); C474(1.17); C2403(1.30)  LDD1594  [19]
 LDCM0391  CL120 PaTu 8988t C474(1.30)  LDD1270  [7]
 LDCM0392  CL121 PaTu 8988t C474(0.78)  LDD1271  [7]
 LDCM0393  CL122 PaTu 8988t C474(0.76)  LDD1272  [7]
 LDCM0394  CL123 PaTu 8988t C474(0.68)  LDD1273  [7]
 LDCM0395  CL124 PaTu 8988t C474(0.71)  LDD1274  [7]
 LDCM0396  CL125 HEK-293T C987(1.15)  LDD0994  [7]
 LDCM0397  CL126 HEK-293T C987(1.08)  LDD0995  [7]
 LDCM0398  CL127 HEK-293T C987(1.18)  LDD0996  [7]
 LDCM0399  CL128 HEK-293T C987(0.99)  LDD0997  [7]
 LDCM0400  CL13 HEK-293T C2322(0.98); C1274(1.08); C474(1.08); C2403(1.08)  LDD1604  [19]
 LDCM0401  CL14 HEK-293T C2322(0.99); C1274(1.05); C474(0.97); C2403(1.22)  LDD1605  [19]
 LDCM0402  CL15 HEK-293T C2322(0.96); C1274(0.99); C474(1.06); C2403(1.04)  LDD1606  [19]
 LDCM0403  CL16 HEK-293T C2322(0.95); C1274(1.05); C474(0.95); C2403(1.02)  LDD1607  [19]
 LDCM0404  CL17 HEK-293T C2322(1.26); C1274(0.98); C474(1.04); C2403(1.11)  LDD1608  [19]
 LDCM0405  CL18 HEK-293T C2322(0.96); C1274(1.07); C474(1.21); C2403(0.93)  LDD1609  [19]
 LDCM0406  CL19 HEK-293T C2322(1.22); C1274(1.12); C474(0.96); C2403(1.11)  LDD1610  [19]
 LDCM0407  CL2 HEK-293T C2322(1.04); C1274(1.03); C474(0.99); C2403(1.04)  LDD1611  [19]
 LDCM0408  CL20 HEK-293T C2322(1.24); C1274(1.22); C474(1.05); C2403(1.14)  LDD1612  [19]
 LDCM0409  CL21 HEK-293T C2322(0.91); C1274(0.99); C474(0.99); C2403(0.99)  LDD1613  [19]
 LDCM0410  CL22 HEK-293T C2322(1.18); C1274(0.89); C474(1.00); C2403(1.10)  LDD1614  [19]
 LDCM0411  CL23 HEK-293T C2322(0.56); C1274(0.99); C474(0.97); C2403(1.20)  LDD1615  [19]
 LDCM0412  CL24 HEK-293T C2322(1.67); C1274(1.03); C474(1.10); C2403(1.09)  LDD1616  [19]
 LDCM0413  CL25 HEK-293T C2322(0.84); C1274(1.00); C474(1.04); C2403(0.98)  LDD1617  [19]
 LDCM0414  CL26 HEK-293T C2322(1.03); C1274(1.11); C474(0.98); C2403(1.15)  LDD1618  [19]
 LDCM0415  CL27 HEK-293T C2322(0.99); C1274(1.08); C474(0.92); C2403(1.08)  LDD1619  [19]
 LDCM0416  CL28 HEK-293T C2322(0.97); C1274(0.94); C474(0.95); C2403(0.90)  LDD1620  [19]
 LDCM0417  CL29 HEK-293T C2322(1.05); C1274(1.11); C474(0.83); C2403(0.95)  LDD1621  [19]
 LDCM0418  CL3 HEK-293T C2322(0.97); C1274(1.02); C474(1.20); C2403(1.00)  LDD1622  [19]
 LDCM0419  CL30 HEK-293T C2322(0.96); C1274(1.12); C474(1.15); C2403(0.99)  LDD1623  [19]
 LDCM0420  CL31 HEK-293T C987(0.65)  LDD1018  [7]
 LDCM0421  CL32 HEK-293T C987(1.03)  LDD1019  [7]
 LDCM0422  CL33 HEK-293T C987(0.86)  LDD1020  [7]
 LDCM0423  CL34 HEK-293T C987(1.11)  LDD1021  [7]
 LDCM0424  CL35 HEK-293T C987(0.93)  LDD1022  [7]
 LDCM0425  CL36 HEK-293T C987(1.04)  LDD1023  [7]
 LDCM0426  CL37 HEK-293T C987(1.19)  LDD1024  [7]
 LDCM0428  CL39 HEK-293T C987(1.27)  LDD1026  [7]
 LDCM0429  CL4 HEK-293T C2322(0.89); C1274(0.99); C474(0.91); C2403(0.88)  LDD1633  [19]
 LDCM0430  CL40 HEK-293T C987(0.90)  LDD1028  [7]
 LDCM0431  CL41 HEK-293T C987(1.11)  LDD1029  [7]
 LDCM0432  CL42 HEK-293T C987(1.14)  LDD1030  [7]
 LDCM0433  CL43 HEK-293T C987(1.39)  LDD1031  [7]
 LDCM0434  CL44 HEK-293T C987(0.86)  LDD1032  [7]
 LDCM0435  CL45 HEK-293T C987(0.97)  LDD1033  [7]
 LDCM0436  CL46 PaTu 8988t C474(0.77)  LDD1315  [7]
 LDCM0437  CL47 PaTu 8988t C474(0.99)  LDD1316  [7]
 LDCM0438  CL48 PaTu 8988t C474(1.29)  LDD1317  [7]
 LDCM0439  CL49 PaTu 8988t C474(0.93)  LDD1318  [7]
 LDCM0440  CL5 HEK-293T C2322(1.12); C1274(0.99); C474(1.12); C2403(1.18)  LDD1644  [19]
 LDCM0441  CL50 PaTu 8988t C474(1.06)  LDD1320  [7]
 LDCM0442  CL51 PaTu 8988t C474(1.01)  LDD1321  [7]
 LDCM0443  CL52 PaTu 8988t C474(0.85)  LDD1322  [7]
 LDCM0444  CL53 PaTu 8988t C474(0.56)  LDD1323  [7]
 LDCM0445  CL54 PaTu 8988t C474(0.64)  LDD1324  [7]
 LDCM0446  CL55 PaTu 8988t C474(0.96)  LDD1325  [7]
 LDCM0447  CL56 PaTu 8988t C474(0.92)  LDD1326  [7]
 LDCM0448  CL57 PaTu 8988t C474(0.89)  LDD1327  [7]
 LDCM0449  CL58 PaTu 8988t C474(1.08)  LDD1328  [7]
 LDCM0450  CL59 PaTu 8988t C474(1.21)  LDD1329  [7]
 LDCM0451  CL6 HEK-293T C2322(0.91); C1274(1.00); C474(1.16); C2403(0.81)  LDD1654  [19]
 LDCM0452  CL60 PaTu 8988t C474(1.02)  LDD1331  [7]
 LDCM0453  CL61 PaTu 8988t C474(1.05)  LDD1332  [7]
 LDCM0454  CL62 PaTu 8988t C474(1.19)  LDD1333  [7]
 LDCM0455  CL63 PaTu 8988t C474(0.81)  LDD1334  [7]
 LDCM0456  CL64 PaTu 8988t C474(1.06)  LDD1335  [7]
 LDCM0457  CL65 PaTu 8988t C474(0.92)  LDD1336  [7]
 LDCM0458  CL66 PaTu 8988t C474(0.81)  LDD1337  [7]
 LDCM0459  CL67 PaTu 8988t C474(1.21)  LDD1338  [7]
 LDCM0460  CL68 PaTu 8988t C474(0.84)  LDD1339  [7]
 LDCM0461  CL69 PaTu 8988t C474(0.95)  LDD1340  [7]
 LDCM0462  CL7 HEK-293T C2322(1.11); C1274(1.04); C474(1.03); C2403(1.01)  LDD1665  [19]
 LDCM0463  CL70 PaTu 8988t C474(0.64)  LDD1342  [7]
 LDCM0464  CL71 PaTu 8988t C474(1.07)  LDD1343  [7]
 LDCM0465  CL72 PaTu 8988t C474(0.81)  LDD1344  [7]
 LDCM0466  CL73 PaTu 8988t C474(1.20)  LDD1345  [7]
 LDCM0467  CL74 PaTu 8988t C474(0.84)  LDD1346  [7]
 LDCM0469  CL76 HEK-293T C2322(0.91); C1274(1.05); C474(0.96); C2403(0.97)  LDD1672  [19]
 LDCM0470  CL77 HEK-293T C2322(0.78); C1274(1.10); C474(0.98); C2403(1.11)  LDD1673  [19]
 LDCM0471  CL78 HEK-293T C2322(0.98); C1274(1.10); C474(1.04); C2403(1.08)  LDD1674  [19]
 LDCM0472  CL79 HEK-293T C2322(1.06); C1274(0.97); C474(1.06); C2403(1.03)  LDD1675  [19]
 LDCM0473  CL8 HEK-293T C2322(0.90); C1274(0.94); C474(1.34); C2403(1.01)  LDD1676  [19]
 LDCM0474  CL80 HEK-293T C2322(1.07); C1274(1.12); C474(0.99); C2403(1.23)  LDD1677  [19]
 LDCM0475  CL81 HEK-293T C2322(0.90); C1274(1.09); C474(0.94); C2403(1.09)  LDD1678  [19]
 LDCM0476  CL82 HEK-293T C2322(1.16); C1274(0.93); C474(0.99); C2403(1.11)  LDD1679  [19]
 LDCM0477  CL83 HEK-293T C2322(0.55); C1274(0.98); C474(0.90); C2403(0.95)  LDD1680  [19]
 LDCM0478  CL84 HEK-293T C2322(1.25); C1274(1.11); C474(0.90); C2403(0.94)  LDD1681  [19]
 LDCM0479  CL85 HEK-293T C2322(0.94); C1274(0.91); C474(1.17); C2403(1.01)  LDD1682  [19]
 LDCM0480  CL86 HEK-293T C2322(1.00); C1274(1.00); C474(0.97); C2403(1.08)  LDD1683  [19]
 LDCM0481  CL87 HEK-293T C2322(0.80); C1274(0.98); C474(1.05); C2403(1.05)  LDD1684  [19]
 LDCM0482  CL88 HEK-293T C2322(0.95); C1274(0.97); C474(1.05); C2403(0.99)  LDD1685  [19]
 LDCM0483  CL89 HEK-293T C2322(0.74); C1274(1.02); C474(0.86); C2403(0.98)  LDD1686  [19]
 LDCM0484  CL9 HEK-293T C2322(0.86); C1274(0.99); C474(1.10); C2403(0.90)  LDD1687  [19]
 LDCM0485  CL90 HEK-293T C2322(0.79); C1274(0.90); C474(1.52); C2403(0.77)  LDD1688  [19]
 LDCM0486  CL91 PaTu 8988t C474(1.27)  LDD1365  [7]
 LDCM0487  CL92 PaTu 8988t C474(1.31)  LDD1366  [7]
 LDCM0488  CL93 PaTu 8988t C474(1.21)  LDD1367  [7]
 LDCM0489  CL94 PaTu 8988t C474(2.71)  LDD1368  [7]
 LDCM0490  CL95 PaTu 8988t C474(1.84)  LDD1369  [7]
 LDCM0491  CL96 PaTu 8988t C474(1.26)  LDD1370  [7]
 LDCM0492  CL97 PaTu 8988t C474(1.02)  LDD1371  [7]
 LDCM0493  CL98 PaTu 8988t C474(1.37)  LDD1372  [7]
 LDCM0494  CL99 PaTu 8988t C474(1.26)  LDD1373  [7]
 LDCM0495  E2913 HEK-293T C2322(1.12); C1274(1.18); C474(0.92); C2403(1.24)  LDD1698  [19]
 LDCM0586  Fragment28 Ramos C1274(4.20)  LDD2198  [20]
 LDCM0468  Fragment33 PaTu 8988t C474(0.87)  LDD1347  [7]
 LDCM0427  Fragment51 HEK-293T C987(0.82)  LDD1025  [7]
 LDCM0569  Fragment7 Ramos C1274(1.90)  LDD2186  [20]
 LDCM0116  HHS-0101 DM93 Y465(0.84); Y1212(1.04)  LDD0264  [5]
 LDCM0117  HHS-0201 DM93 Y1212(0.81); Y465(0.85)  LDD0265  [5]
 LDCM0118  HHS-0301 DM93 Y465(0.88); Y1212(1.15)  LDD0266  [5]
 LDCM0119  HHS-0401 DM93 Y1212(0.81); Y465(1.80)  LDD0267  [5]
 LDCM0120  HHS-0701 DM93 Y1212(1.25); Y465(1.52)  LDD0268  [5]
 LDCM0022  KB02 HEK-293T C2322(0.96); C994(0.99); C2403(0.93); C1274(0.97)  LDD1492  [19]
 LDCM0023  KB03 HEK-293T C2322(1.00); C994(0.95); C2403(1.05); C1274(1.13)  LDD1497  [19]
 LDCM0024  KB05 SKMEL24 C2056(1.99)  LDD3323  [21]
 LDCM0109  NEM HeLa H131(0.00); H1448(0.00)  LDD0227  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Peptidyl-prolyl cis-trans isomerase A (PPIA) Cyclophilin-type PPIase family P62937
Histone deacetylase 3 (HDAC3) Histone deacetylase family O15379
Septin-5 (SEPTIN5) Septin GTPase family Q99719
Transcription intermediary factor 1-beta (TRIM28) TRIM/RBCC family Q13263
Transporter and channel
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Importin subunit alpha-3 (KPNA4) Importin alpha family O00629
Oxysterols receptor LXR-alpha (NR1H3) Nuclear hormone receptor family Q13133
Peroxisome proliferator-activated receptor alpha (PPARA) Nuclear hormone receptor family Q07869
Syntaxin-binding protein 1 (STXBP1) STXBP/unc-18/SEC1 family P61764
Transcription factor
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Dachshund homolog 1 (DACH1) DACH/dachshund family Q9UI36
Nuclear receptor subfamily 1 group D member 1 (NR1D1) Nuclear hormone receptor family P20393
Oxysterols receptor LXR-beta (NR1H2) Nuclear hormone receptor family P55055
Peroxisome proliferator-activated receptor gamma (PPARG) Nuclear hormone receptor family P37231
Retinoic acid receptor alpha (RARA) Nuclear hormone receptor family P10276
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein CBFA2T1 (RUNX1T1) CBFA2T family Q06455
Protein Hook homolog 1 (HOOK1) Hook family Q9UJC3
Ski oncogene (SKI) SKI family P12755

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
13 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
14 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
15 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
16 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
17 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
18 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
19 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
20 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
21 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840