Details of the Target

General Information of Target

Target ID LDTP13957
Target Name Ubiquitin-conjugating enzyme E2 J1 (UBE2J1)
Gene Name UBE2J1
Gene ID 51465
Synonyms
NCUBE1; Ubiquitin-conjugating enzyme E2 J1; EC 2.3.2.23; E2 ubiquitin-conjugating enzyme J1; Non-canonical ubiquitin-conjugating enzyme 1; NCUBE-1; Yeast ubiquitin-conjugating enzyme UBC6 homolog E; HsUBC6e
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSAQAQMRAMLDQLMGTSRDGDTTRQRIKFSDDRVCKSHLLNCCPHDVLSGTRMDLGECL
KVHDLALRADYEIASKEQDFFFELDAMDHLQSFIADCDRRTEVAKKRLAETQEEISAEVA
AKAERVHELNEEIGKLLAKVEQLGAEGNVEESQKVMDEVEKARAKKREAEEVYRNSMPAS
SFQQQKLRVCEVCSAYLGLHDNDRRLADHFGGKLHLGFIEIREKLEELKRVVAEKQEKRN
QERLKRREEREREEREKLRRSRSHSKNPKRSRSREHRRHRSRSMSRERKRRTRSKSREKR
HRHRSRSSSRSRSRSHQRSRHSSRDRSRERSKRRSSKERFRDQDLASCDRDRSSRDRSPR
DRDRKDKKRSYESANGRSEDRRSSEEREAGEI
Target Bioclass
Enzyme
Family
Ubiquitin-conjugating enzyme family
Subcellular location
Endoplasmic reticulum membrane
Function
Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD) and is essential for cells to recover from ER stress. Plays a role in MAPKAPK2-dependent translational control of TNF-alpha synthesis. Acts also as a platform for perinuclear positioning of the endosomal system by mediating ubiquitination of SQSTM1 through interaction with the E3 ubiquitin-protein ligase RNF26. Plays a role in male fecundity through the interaction with the E3 ubiquitin-protein ligase RNF133. {|PROSITE-ProRule:PRU00388}.; (Microbial infection) Promotes Dengue virus RNA replication by negatively regulating IFN-beta signaling and mediating 'Lys-48'-linked ubiquitination on IRF3.
Uniprot ID
Q9Y385
Ensemble ID
ENST00000435041.3
HGNC ID
HGNC:17598

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K8(9.55)  LDD0277  [1]
Probe 1
 Probe Info  		Y132(13.48)  LDD3495  [2]
DBIA
 Probe Info  		C148(0.99)  LDD0080  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [5]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [4]
AOyne
 Probe Info  		11.00  LDD0443  [6]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C218
 Probe Info  		11.88  LDD1892  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C148(0.79); C149(0.94); C152(0.94)  LDD0812  [3]
 LDCM0215  AC10 HCT 116 C148(1.08); C152(1.10)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C148(0.55); C149(0.58); C152(0.55)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C148(0.51); C149(0.55); C152(0.51)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C148(0.66); C149(0.58); C152(0.60)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C148(0.56); C149(0.54); C152(0.56)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C148(0.63); C149(0.60); C152(0.60)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C148(0.58); C149(0.58); C152(0.58)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C148(0.53); C149(0.54); C152(0.53)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C148(0.54); C149(0.61); C152(0.60)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C148(0.56); C149(0.68); C152(0.66)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C148(0.69); C149(0.90); C152(0.92)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C148(0.80); C152(0.84)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C148(0.57); C149(0.83); C152(0.81)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C148(0.59); C149(0.65); C152(0.63)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C148(0.55); C149(0.69); C152(0.61)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C148(1.14); C149(1.03); C152(1.04)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C148(0.80); C149(0.62); C152(0.77)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C148(0.71); C149(0.55); C152(0.75)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C148(0.73); C149(0.51); C152(0.80)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C148(0.91); C149(0.83); C152(1.20)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C148(0.86); C149(0.66); C152(0.91)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C148(0.86); C149(0.73); C152(0.87)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C148(1.05); C152(1.26)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C148(0.86); C149(0.67); C152(0.78)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C148(0.96); C149(0.87); C152(1.36)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C148(0.78); C149(0.61); C152(0.74)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C148(0.90); C149(0.71); C152(1.18)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C148(0.93); C149(0.84); C152(1.03)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C148(0.92); C149(0.79); C152(0.81)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C148(0.84); C149(0.59); C152(0.77)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C148(0.78); C149(0.53); C152(0.83)  LDD0562  [3]
 LDCM0246  AC128 HCT 116 C148(0.83); C149(0.83); C152(0.83)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C148(0.60); C149(0.67); C152(0.67)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C148(0.60); C149(0.64); C152(0.64)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C148(0.77); C149(0.67); C152(0.67)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C148(0.70); C149(0.67); C152(0.67)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C148(0.66); C149(0.64); C152(0.64)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C148(0.69); C149(0.70); C152(0.70)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C148(0.67); C149(0.67); C152(0.67)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C148(0.63); C149(0.65); C152(0.65)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C148(0.60); C149(0.63); C152(0.63)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C148(0.56); C149(0.62); C152(0.62)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C148(0.60); C149(0.61); C152(0.61)  LDD0575  [3]
 LDCM0259  AC14 HCT 116 C148(1.00); C152(1.12)  LDD0576  [3]
 LDCM0260  AC140 HCT 116 C148(0.58); C149(0.61); C152(0.61)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C148(0.58); C149(0.58); C152(0.58)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C148(0.58); C149(0.55); C152(0.55)  LDD0579  [3]
 LDCM0263  AC143 HCT 116 C152(0.75); C148(0.79); C149(0.83)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C152(0.67); C149(0.71); C148(0.79)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C152(0.79); C149(0.90); C148(0.98)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C149(0.73); C152(0.74); C148(0.86)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C152(0.65); C149(0.76); C148(0.83)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C152(0.67); C149(0.71); C148(0.76)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C149(0.67); C148(0.70); C152(0.81)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C148(1.16); C152(1.22)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C152(0.82); C149(0.96); C148(1.02)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C149(0.87); C148(0.90); C152(0.92)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C149(0.73); C152(0.76); C148(0.84)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C149(0.76); C152(0.83); C148(0.85)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C148(0.97); C149(0.85); C152(0.75)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C148(0.95); C149(0.85); C152(0.83)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C148(1.04); C149(1.13); C152(1.19)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C148(1.08); C149(1.02); C152(1.08)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C152(0.99); C149(1.04); C148(1.04)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C149(0.60); C152(0.67); C148(0.81)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C148(1.06); C152(1.13); C149(1.35)  LDD0595  [3]
 LDCM0279  AC2 HEK-293T C148(0.70); C149(0.81); C152(0.81)  LDD0877  [3]
 LDCM0280  AC20 HCT 116 C152(0.97); C149(0.99); C148(1.05)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C148(1.02); C149(1.06); C152(1.13)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C148(1.28); C149(1.39); C152(1.44)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C148(1.10); C152(1.17); C149(1.21)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C152(1.22); C148(1.22); C149(1.33)  LDD0601  [3]
 LDCM0285  AC25 HEK-293T C148(2.97); C149(2.03); C152(2.50)  LDD0883  [3]
 LDCM0286  AC26 HEK-293T C148(1.70); C149(1.20); C152(1.45)  LDD0884  [3]
 LDCM0287  AC27 HEK-293T C148(1.19); C149(1.45); C152(1.32)  LDD0885  [3]
 LDCM0288  AC28 HEK-293T C148(1.84); C149(1.58); C152(1.71)  LDD0886  [3]
 LDCM0289  AC29 HEK-293T C148(1.31); C149(1.30); C152(1.31)  LDD0887  [3]
 LDCM0290  AC3 HEK-293T C148(1.01); C149(1.00); C152(1.00)  LDD0888  [3]
 LDCM0291  AC30 HEK-293T C148(1.88); C149(1.27); C152(1.58)  LDD0889  [3]
 LDCM0292  AC31 HEK-293T C148(2.10); C149(1.62); C152(1.86)  LDD0890  [3]
 LDCM0293  AC32 HEK-293T C148(1.34); C149(1.51); C152(1.43)  LDD0891  [3]
 LDCM0294  AC33 HEK-293T C148(1.79); C149(1.50); C152(1.65)  LDD0892  [3]
 LDCM0295  AC34 HEK-293T C148(1.48); C149(1.40); C152(1.44)  LDD0893  [3]
 LDCM0296  AC35 HCT 116 C148(1.45); C149(1.45); C152(1.45)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C148(1.36); C149(1.36); C152(1.36)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C148(1.48); C149(1.48); C152(1.48)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C148(1.19); C149(1.19); C152(1.19)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C148(1.13); C149(1.13); C152(1.13)  LDD0617  [3]
 LDCM0301  AC4 HEK-293T C148(0.94); C149(1.02); C152(1.02)  LDD0899  [3]
 LDCM0302  AC40 HCT 116 C148(1.20); C149(1.20); C152(1.20)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C148(1.15); C149(1.15); C152(1.15)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C148(0.92); C149(0.92); C152(0.92)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C148(0.92); C149(0.92); C152(0.92)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C148(1.02); C149(1.02); C152(1.02)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C148(0.98); C149(0.98); C152(0.98)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C148(0.84); C149(0.84)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C148(0.90); C149(0.90)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C148(1.31); C149(1.31)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C148(0.90); C149(0.90)  LDD0628  [3]
 LDCM0312  AC5 HEK-293T C148(0.90); C149(0.96); C152(0.96)  LDD0910  [3]
 LDCM0313  AC50 HCT 116 C148(0.94); C149(0.94)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C148(0.91); C149(0.91)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C148(1.34); C149(1.34)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C148(1.05); C149(1.05)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C148(1.28); C149(1.28)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C148(1.08); C149(1.08)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C148(1.06); C149(1.06)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C148(0.35); C149(0.35); C152(0.35)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C148(0.34); C149(0.34); C152(0.34)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C148(0.43); C149(0.43); C152(0.43)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C152(0.88); C148(1.02)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C148(0.30); C149(0.30); C152(0.30)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C148(0.27); C149(0.27); C152(0.27)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C148(0.35); C149(0.35); C152(0.35)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C148(0.37); C149(0.37); C152(0.37)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C148(0.32); C149(0.32); C152(0.32)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C148(0.24); C149(0.24); C152(0.24)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C148(0.24); C149(0.24); C152(0.24)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C148(0.18); C149(0.18); C152(0.18)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C149(0.77); C148(0.89); C152(0.91)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C149(0.65); C148(0.76); C152(0.79)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C148(0.94); C152(0.98)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C149(0.85); C152(1.06); C148(1.10)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C149(0.81); C148(1.06); C152(1.08)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C149(0.65); C148(0.88); C152(0.93)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C149(0.61); C148(0.85); C152(0.88)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C149(0.58); C148(0.80); C152(0.84)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C149(0.69); C148(0.82); C152(0.85)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C149(0.56); C148(0.74); C152(0.75)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C149(0.58); C148(0.74); C152(0.77)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C149(0.65); C148(0.82); C152(0.84)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C149(0.76); C148(0.81); C152(0.88)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C148(0.95); C152(1.01)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C149(0.69); C148(0.81); C152(0.84)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C149(0.92); C148(0.95); C152(0.95)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C149(0.68); C148(0.78); C152(0.80)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C149(1.57); C152(1.57)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C149(1.36); C152(1.36)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C149(1.84); C152(1.84)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C149(1.57); C152(1.57)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C149(1.36); C152(1.36)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C149(1.27); C152(1.27)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C149(1.21); C152(1.21)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C149(1.17); C152(1.17)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C149(1.46); C152(1.46)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C149(1.48); C152(1.48)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C149(1.20); C152(1.20)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C149(2.14); C152(2.14)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C149(1.35); C152(1.35)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C149(1.73); C152(1.73)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C149(1.08); C152(1.08)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C148(0.48); C152(0.48); C149(0.49)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C149(0.56); C152(0.58); C148(0.58)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C148(0.95); C152(1.00)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C152(0.76); C148(0.86)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C148(1.15); C152(1.22)  LDD0592  [3]
 LDCM0367  CL1 HCT 116 C148(1.29); C149(1.29); C152(1.38)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C152(0.76); C148(0.81); C149(0.81)  LDD0685  [3]
 LDCM0369  CL100 HEK-293T C148(1.12); C149(1.29); C152(1.29)  LDD0967  [3]
 LDCM0370  CL101 HCT 116 C148(0.98); C152(1.00)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C148(0.95); C152(1.05)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C148(0.87); C152(0.92)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C148(1.00); C152(1.12)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C149(0.83); C152(0.92); C148(0.94)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C149(0.55); C152(0.63); C148(0.73)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C149(0.61); C152(0.74); C148(0.83)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C149(0.55); C152(0.65); C148(0.93)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C148(0.83); C152(0.84); C149(0.85)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C152(0.68); C148(0.83); C149(0.83)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C152(0.91); C148(0.94); C149(1.00)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C148(0.89); C152(0.92); C149(0.99)  LDD0698  [3]
 LDCM0382  CL112 HEK-293T C148(1.09); C149(1.20); C152(1.14)  LDD0980  [3]
 LDCM0383  CL113 HEK-293T C148(1.22); C149(1.61); C152(1.42)  LDD0981  [3]
 LDCM0384  CL114 HEK-293T C148(1.17); C149(1.48); C152(1.33)  LDD0982  [3]
 LDCM0385  CL115 HEK-293T C148(2.33); C149(1.43); C152(1.88)  LDD0983  [3]
 LDCM0386  CL116 HEK-293T C148(1.81); C149(1.71); C152(1.76)  LDD0984  [3]
 LDCM0387  CL117 HCT 116 C148(1.03); C149(1.03); C152(1.03)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C148(0.96); C149(0.96); C152(0.96)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C148(1.12); C149(1.12); C152(1.12)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C152(0.68); C148(0.82); C149(0.82)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C148(1.20); C149(1.20); C152(1.20)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C148(0.93); C149(0.93)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C148(1.02); C149(1.02)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C148(1.26); C149(1.26)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C148(1.19); C149(1.19)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C148(0.69); C149(0.69); C152(0.69)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C148(0.58); C149(0.58); C152(0.58)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C148(0.58); C149(0.58); C152(0.58)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C148(0.41); C149(0.41); C152(0.41)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C152(0.63); C148(0.86); C149(0.86)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C152(0.88); C148(0.89); C149(0.89)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C152(0.70); C148(0.84); C149(0.84)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C152(0.84); C149(0.87); C148(0.89)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C148(0.77); C149(0.77); C152(0.77)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C148(0.64); C149(0.64); C152(0.64)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C148(0.74); C149(0.74); C152(0.74)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C148(0.91); C149(0.91); C152(0.92)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C148(0.65); C149(0.65); C152(0.65)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C148(0.76); C149(0.76); C152(0.76)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C148(0.67); C149(0.67); C152(0.67)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C148(0.70); C149(0.70); C152(0.70)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C148(0.73); C149(0.73); C152(0.73)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C148(0.69); C149(0.69); C152(0.69)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C148(0.69); C149(0.69); C152(0.69)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C148(0.83); C149(0.83); C152(0.83)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C148(0.71); C149(0.71); C152(0.71)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C148(0.79); C149(0.79); C152(0.79)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C148(0.94); C149(0.94); C152(0.92)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C148(0.86); C149(0.86); C152(0.86)  LDD0736  [3]
 LDCM0420  CL31 HEK-293T C149(0.98); C152(0.98)  LDD1018  [3]
 LDCM0421  CL32 HCT 116 C148(1.05); C149(0.92); C152(0.80)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C148(0.87); C149(0.90); C152(0.93)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C148(1.09); C149(1.04); C152(1.00)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C148(1.23); C149(1.23); C152(1.22)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C148(1.14); C149(1.15); C152(1.16)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C148(1.38); C149(1.32); C152(1.26)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C148(1.08); C149(1.04); C152(1.01)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C148(1.19); C149(1.19); C152(1.30)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C148(0.88); C149(0.93); C152(0.97)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C148(1.07); C149(1.00); C152(0.93)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C148(0.85); C149(1.10); C152(1.35)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C148(1.09); C149(1.00); C152(0.91)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C148(1.25); C149(1.26); C152(1.27)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C148(1.24); C149(1.14); C152(1.04)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C148(1.73); C149(1.28); C152(1.28)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C148(1.57); C149(1.26); C152(1.26)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C148(1.71); C149(1.36); C152(1.36)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C148(1.29); C149(1.15); C152(1.15)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C148(0.90); C149(0.90); C152(0.85)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C148(1.19); C149(1.05); C152(1.05)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C148(1.68); C149(1.30); C152(1.30)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C148(1.56); C149(1.22); C152(1.22)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C148(1.56); C149(1.36); C152(1.36)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C148(2.08); C149(1.47); C152(1.47)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C148(1.73); C149(1.39); C152(1.39)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C148(1.26); C149(1.13); C152(1.13)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C148(1.77); C149(1.43); C152(1.43)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C148(1.64); C149(1.19); C152(1.19)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C148(1.58); C149(1.27); C152(1.27)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C148(0.78); C149(0.78); C152(0.67)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C148(1.47); C149(1.26); C152(1.26)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C148(0.95); C149(1.03); C152(1.10)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C148(0.86); C149(0.89); C152(0.92)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C148(0.75); C149(0.80); C152(0.75)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C148(0.78); C149(0.96); C152(0.78)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C148(0.84); C149(0.83); C152(0.84)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C148(0.69); C149(0.74); C152(0.65)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C148(0.75); C149(0.78); C152(0.75)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C148(0.81); C149(0.85); C152(0.89)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C148(0.70); C149(0.74); C152(0.70)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C148(0.90); C149(0.90); C152(0.75)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C148(0.78); C149(0.80); C152(0.78)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C148(0.86); C149(0.88); C152(0.89)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C148(0.97); C149(0.98); C152(0.97)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C148(0.84); C149(0.87); C152(0.84)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C148(0.75); C149(0.80); C152(0.75)  LDD0784  [3]
 LDCM0469  CL76 HEK-293T C149(1.01); C152(1.01)  LDD1067  [3]
 LDCM0470  CL77 HEK-293T C149(0.66); C152(0.66)  LDD1068  [3]
 LDCM0471  CL78 HEK-293T C149(0.69); C152(0.69)  LDD1069  [3]
 LDCM0472  CL79 HEK-293T C149(0.85); C152(0.85)  LDD1070  [3]
 LDCM0473  CL8 HCT 116 C148(0.69); C149(0.69); C152(0.66)  LDD0790  [3]
 LDCM0474  CL80 HEK-293T C149(0.76); C152(0.76)  LDD1072  [3]
 LDCM0475  CL81 HEK-293T C149(0.82); C152(0.82)  LDD1073  [3]
 LDCM0476  CL82 HEK-293T C149(0.61); C152(0.61)  LDD1074  [3]
 LDCM0477  CL83 HEK-293T C149(0.83); C152(0.83)  LDD1075  [3]
 LDCM0478  CL84 HEK-293T C149(0.73); C152(0.73)  LDD1076  [3]
 LDCM0479  CL85 HEK-293T C149(0.66); C152(0.66)  LDD1077  [3]
 LDCM0480  CL86 HEK-293T C149(0.75); C152(0.75)  LDD1078  [3]
 LDCM0481  CL87 HEK-293T C149(0.66); C152(0.66)  LDD1079  [3]
 LDCM0482  CL88 HEK-293T C149(0.77); C152(0.77)  LDD1080  [3]
 LDCM0483  CL89 HEK-293T C149(0.90); C152(0.90)  LDD1081  [3]
 LDCM0484  CL9 HCT 116 C148(0.85); C149(0.85); C152(0.77)  LDD0801  [3]
 LDCM0485  CL90 HEK-293T C149(0.68); C152(0.68)  LDD1083  [3]
 LDCM0486  CL91 HEK-293T C148(0.79); C149(1.08); C152(1.08)  LDD1084  [3]
 LDCM0487  CL92 HEK-293T C148(1.39); C149(1.13); C152(1.13)  LDD1085  [3]
 LDCM0488  CL93 HEK-293T C148(0.84); C149(0.89); C152(0.89)  LDD1086  [3]
 LDCM0489  CL94 HEK-293T C148(0.86); C149(0.82); C152(0.82)  LDD1087  [3]
 LDCM0490  CL95 HEK-293T C148(0.78); C149(0.79); C152(0.79)  LDD1088  [3]
 LDCM0491  CL96 HEK-293T C148(0.79); C149(0.77); C152(0.77)  LDD1089  [3]
 LDCM0492  CL97 HEK-293T C148(0.93); C149(0.85); C152(0.85)  LDD1090  [3]
 LDCM0493  CL98 HEK-293T C148(0.90); C149(0.92); C152(0.92)  LDD1091  [3]
 LDCM0494  CL99 HEK-293T C148(0.97); C149(0.90); C152(0.90)  LDD1092  [3]
 LDCM0495  E2913 HEK-293T C91(0.93)  LDD1698  [8]
 LDCM0625  F8 Ramos C91(1.32)  LDD2187  [9]
 LDCM0573  Fragment11 Ramos C91(0.11)  LDD2190  [9]
 LDCM0576  Fragment14 Ramos C91(0.67)  LDD2193  [9]
 LDCM0586  Fragment28 Ramos C91(4.89)  LDD2198  [9]
 LDCM0468  Fragment33 HCT 116 C148(0.87); C149(0.98); C152(0.87)  LDD0785  [3]
 LDCM0566  Fragment4 Ramos C91(0.68)  LDD2184  [9]
 LDCM0427  Fragment51 HCT 116 C148(1.01); C149(1.12); C152(1.22)  LDD0744  [3]
 LDCM0569  Fragment7 Ramos C91(0.57)  LDD2186  [9]
 LDCM0022  KB02 HCT 116 C148(0.99)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C148(1.09)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C148(1.37)  LDD0082  [3]
 LDCM0131  RA190 MM1.R C148(1.11); C152(1.11)  LDD0304  [10]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Phosphatidate cytidylyltransferase 1 (CDS1) CDS family Q92903
Palmitoyltransferase ZDHHC15 (ZDHHC15) DHHC palmitoyltransferase family Q96MV8
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) EBP family Q15125
Very long chain fatty acid elongase 4 (ELOVL4) ELO family Q9GZR5
Vesicle transport protein GOT1A (GOLT1A) GOT1 family Q6ZVE7
E3 ubiquitin-protein ligase synoviolin (SYVN1) HRD1 family Q86TM6
Phospholipid phosphatase-related protein type 2 (PLPPR2) PA-phosphatase related phosphoesterase family Q96GM1
Signal peptidase complex catalytic subunit SEC11C (SEC11C) Peptidase S26B family Q9BY50
TLC domain-containing protein 4 (TLCD4) TLCD4 family Q96MV1
Transmembrane ascorbate-dependent reductase CYB561 (CYB561) . P49447
Transporter and channel
Click To Hide/Show 14 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sodium-dependent organic anion transporter (SLC10A6) Bile acid:sodium symporter (BASS) family Q3KNW5
Collectrin (CLTRN) CLTRN family Q9HBJ8
Derlin-1 (DERL1) Derlin family Q9BUN8
Gastrokine-1 (GKN1) Gastrokine family Q9NS71
Transmembrane 4 L6 family member 18 (TM4SF18) L6 tetraspanin family Q96CE8
Transmembrane 4 L6 family member 19 (TM4SF19) L6 tetraspanin family Q96DZ7
Lysosomal-associated transmembrane protein 5 (LAPTM5) LAPTM4/LAPTM5 transporter family Q13571
Hippocampus abundant transcript-like protein 1 (MFSD14B) Major facilitator superfamily Q5SR56
Major facilitator superfamily domain-containing protein 3 (MFSD3) Major facilitator superfamily Q96ES6
Membrane-spanning 4-domains subfamily A member 6E (MS4A6E) MS4A family Q96DS6
Transmembrane protein 14B (TMEM14B) TMEM14 family Q9NUH8
Zinc transporter ZIP2 (SLC39A2) ZIP transporter (TC 2.A.5) family Q9NP94
Lymphatic vessel endothelial hyaluronic acid receptor 1 (LYVE1) . Q9Y5Y7
Thioredoxin-related transmembrane protein 2 (TMX2) . Q9Y320
GPCR
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Prokineticin receptor 2 (PROKR2) G-protein coupled receptor 1 family Q8NFJ6
Thyrotropin-releasing hormone receptor (TRHR) G-protein coupled receptor 1 family P34981
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
B-cell antigen receptor complex-associated protein alpha chain (CD79A) . P11912
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Receptor expression-enhancing protein 4 (REEP4) DP1 family Q9H6H4
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) ERGIC family Q9Y282
Protein FAM209A (FAM209A) FAM209 family Q5JX71
Protein FAM210B, mitochondrial (FAM210B) FAM210 family Q96KR6
Protein jagunal homolog 1 (JAGN1) Jagunal family Q8N5M9
Lymphocyte antigen 6 complex locus protein G6c (LY6G6C) . O95867
Transmembrane protein 51 (TMEM51) . Q9NW97

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
7 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
10 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.