Details of the Target

General Information of Target

Target ID LDTP01589
Target Name CD2 antigen cytoplasmic tail-binding protein 2 (CD2BP2)
Gene Name CD2BP2
Gene ID 10421
Synonyms
KIAA1178; CD2 antigen cytoplasmic tail-binding protein 2; CD2 cytoplasmic domain-binding protein 2; CD2 tail-binding protein 2; U5 snRNP 52K protein; U5-52K
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPKRKVTFQGVGDEEDEDEIIVPKKKLVDPVAGSGGPGSRFKGKHSLDSDEEEDDDDGGS
SKYDILASEDVEGQEAATLPSEGGVRITPFNLQEEMEEGHFDADGNYFLNRDAQIRDSWL
DNIDWVKIRERPPGQRQASDSEEEDSLGQTSMSAQALLEGLLELLLPRETVAGALRRLGA
RGGGKGRKGPGQPSSPQRLDRLSGLADQMVARGNLGVYQETRERLAMRLKGLGCQTLGPH
NPTPPPSLDMFAEELAEEELETPTPTQRGEAESRGDGLVDVMWEYKWENTGDAELYGPFT
SAQMQTWVSEGYFPDGVYCRKLDPPGGQFYNSKRIDFDLYT
Target Bioclass
Other
Subcellular location
Cytoplasm
Function Involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome assembly.
Uniprot ID
O95400
Ensemble ID
ENST00000305596.8
HGNC ID
HGNC:1656

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K321(7.69)  LDD0277  [2]
ONAyne
 Probe Info  		N.A.  LDD0273  [2]
Probe 1
 Probe Info  		Y330(13.21)  LDD3495  [3]
IA-alkyne
 Probe Info  		C234(1.35)  LDD0304  [4]
DBIA
 Probe Info  		C234(1.71)  LDD3323  [5]
NAIA_5
 Probe Info  		C234(20.00)  LDD2227  [6]
AHL-Pu-1
 Probe Info  		C234(3.04)  LDD0168  [7]
HHS-475
 Probe Info  		Y340(0.77)  LDD0264  [8]
Acrolein
 Probe Info  		N.A.  LDD0227  [9]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [10]
NAIA_4
 Probe Info  		N.A.  LDD2226  [6]
IPM
 Probe Info  		N.A.  LDD2156  [11]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [12]
AOyne
 Probe Info  		14.00  LDD0443  [13]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C310
 Probe Info  		7.52  LDD1977  [14]
C347
 Probe Info  		5.21  LDD2008  [14]
FFF probe13
 Probe Info  		12.25  LDD0475  [15]
FFF probe2
 Probe Info  		20.00  LDD0463  [15]
FFF probe3
 Probe Info  		9.11  LDD0465  [15]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C234(3.04)  LDD0168  [7]
 LDCM0026  4SU-RNA+native RNA HEK-293T C234(3.52)  LDD0169  [7]
 LDCM0214  AC1 HEK-293T C234(1.01)  LDD1507  [16]
 LDCM0215  AC10 PaTu 8988t C234(1.33)  LDD1094  [17]
 LDCM0226  AC11 PaTu 8988t C234(1.95)  LDD1105  [17]
 LDCM0237  AC12 PaTu 8988t C234(1.50)  LDD1116  [17]
 LDCM0259  AC14 PaTu 8988t C234(1.20)  LDD1138  [17]
 LDCM0270  AC15 PaTu 8988t C234(1.32)  LDD1149  [17]
 LDCM0276  AC17 HEK-293T C234(1.23)  LDD1515  [16]
 LDCM0277  AC18 HEK-293T C234(1.13)  LDD1516  [16]
 LDCM0278  AC19 HEK-293T C234(0.88)  LDD1517  [16]
 LDCM0279  AC2 HEK-293T C234(1.10)  LDD1518  [16]
 LDCM0280  AC20 HEK-293T C234(1.15)  LDD1519  [16]
 LDCM0281  AC21 HEK-293T C234(1.01)  LDD1520  [16]
 LDCM0282  AC22 HEK-293T C234(1.08)  LDD1521  [16]
 LDCM0283  AC23 HEK-293T C234(1.00)  LDD1522  [16]
 LDCM0284  AC24 HEK-293T C234(1.10)  LDD1523  [16]
 LDCM0285  AC25 HEK-293T C234(1.03)  LDD1524  [16]
 LDCM0286  AC26 HEK-293T C234(1.19)  LDD1525  [16]
 LDCM0287  AC27 HEK-293T C234(1.15)  LDD1526  [16]
 LDCM0288  AC28 HEK-293T C234(1.21)  LDD1527  [16]
 LDCM0289  AC29 HEK-293T C234(1.12)  LDD1528  [16]
 LDCM0290  AC3 HEK-293T C234(0.97)  LDD1529  [16]
 LDCM0291  AC30 HEK-293T C234(1.05)  LDD1530  [16]
 LDCM0292  AC31 HEK-293T C234(0.99)  LDD1531  [16]
 LDCM0293  AC32 HEK-293T C234(1.08)  LDD1532  [16]
 LDCM0294  AC33 HEK-293T C234(0.98)  LDD1533  [16]
 LDCM0295  AC34 HEK-293T C234(1.04)  LDD1534  [16]
 LDCM0296  AC35 PaTu 8988t C234(1.30)  LDD1175  [17]
 LDCM0297  AC36 PaTu 8988t C234(1.47)  LDD1176  [17]
 LDCM0298  AC37 PaTu 8988t C234(1.27)  LDD1177  [17]
 LDCM0299  AC38 PaTu 8988t C234(1.29)  LDD1178  [17]
 LDCM0300  AC39 PaTu 8988t C234(1.42)  LDD1179  [17]
 LDCM0301  AC4 HEK-293T C234(1.05)  LDD1540  [16]
 LDCM0302  AC40 PaTu 8988t C234(1.37)  LDD1181  [17]
 LDCM0303  AC41 PaTu 8988t C234(1.34)  LDD1182  [17]
 LDCM0304  AC42 PaTu 8988t C234(1.32)  LDD1183  [17]
 LDCM0305  AC43 PaTu 8988t C234(1.13)  LDD1184  [17]
 LDCM0306  AC44 PaTu 8988t C234(1.35)  LDD1185  [17]
 LDCM0307  AC45 PaTu 8988t C234(1.37)  LDD1186  [17]
 LDCM0308  AC46 HEK-293T C234(1.02)  LDD1547  [16]
 LDCM0309  AC47 HEK-293T C234(0.99)  LDD1548  [16]
 LDCM0310  AC48 HEK-293T C234(1.24)  LDD1549  [16]
 LDCM0311  AC49 HEK-293T C234(1.11)  LDD1550  [16]
 LDCM0312  AC5 HEK-293T C234(0.94)  LDD1551  [16]
 LDCM0313  AC50 HEK-293T C234(1.09)  LDD1552  [16]
 LDCM0314  AC51 HEK-293T C234(0.95)  LDD1553  [16]
 LDCM0315  AC52 HEK-293T C234(1.11)  LDD1554  [16]
 LDCM0316  AC53 HEK-293T C234(1.21)  LDD1555  [16]
 LDCM0317  AC54 HEK-293T C234(1.08)  LDD1556  [16]
 LDCM0318  AC55 HEK-293T C234(1.10)  LDD1557  [16]
 LDCM0319  AC56 HEK-293T C234(1.20)  LDD1558  [16]
 LDCM0320  AC57 HEK-293T C234(1.20)  LDD1559  [16]
 LDCM0321  AC58 HEK-293T C234(1.16)  LDD1560  [16]
 LDCM0322  AC59 HEK-293T C234(0.91)  LDD1561  [16]
 LDCM0323  AC6 PaTu 8988t C234(1.67)  LDD1202  [17]
 LDCM0324  AC60 HEK-293T C234(1.06)  LDD1563  [16]
 LDCM0325  AC61 HEK-293T C234(0.99)  LDD1564  [16]
 LDCM0326  AC62 HEK-293T C234(1.01)  LDD1565  [16]
 LDCM0327  AC63 HEK-293T C234(0.98)  LDD1566  [16]
 LDCM0328  AC64 HEK-293T C234(1.04)  LDD1567  [16]
 LDCM0334  AC7 PaTu 8988t C234(1.42)  LDD1213  [17]
 LDCM0345  AC8 PaTu 8988t C234(1.47)  LDD1224  [17]
 LDCM0248  AKOS034007472 PaTu 8988t C234(1.76)  LDD1127  [17]
 LDCM0356  AKOS034007680 PaTu 8988t C234(1.91)  LDD1235  [17]
 LDCM0275  AKOS034007705 PaTu 8988t C234(1.98)  LDD1154  [17]
 LDCM0156  Aniline NCI-H1299 11.98  LDD0403  [1]
 LDCM0630  CCW28-3 231MFP C234(1.26)  LDD2214  [18]
 LDCM0632  CL-Sc Hep-G2 C234(20.00)  LDD2227  [6]
 LDCM0367  CL1 HEK-293T C234(0.90)  LDD1571  [16]
 LDCM0368  CL10 HEK-293T C234(0.96)  LDD1572  [16]
 LDCM0369  CL100 HEK-293T C234(1.22)  LDD1573  [16]
 LDCM0370  CL101 PaTu 8988t C234(1.18)  LDD1249  [17]
 LDCM0371  CL102 PaTu 8988t C234(1.70)  LDD1250  [17]
 LDCM0372  CL103 PaTu 8988t C234(1.68)  LDD1251  [17]
 LDCM0373  CL104 PaTu 8988t C234(1.96)  LDD1252  [17]
 LDCM0374  CL105 HEK-293T C234(1.00)  LDD1578  [16]
 LDCM0375  CL106 HEK-293T C234(0.98)  LDD1579  [16]
 LDCM0376  CL107 HEK-293T C234(0.91)  LDD1580  [16]
 LDCM0377  CL108 HEK-293T C234(1.15)  LDD1581  [16]
 LDCM0378  CL109 HEK-293T C234(1.01)  LDD1582  [16]
 LDCM0379  CL11 HEK-293T C234(1.07)  LDD1583  [16]
 LDCM0380  CL110 HEK-293T C234(1.00)  LDD1584  [16]
 LDCM0381  CL111 HEK-293T C234(1.03)  LDD1585  [16]
 LDCM0382  CL112 HEK-293T C234(1.25)  LDD1586  [16]
 LDCM0383  CL113 HEK-293T C234(1.12)  LDD1587  [16]
 LDCM0384  CL114 HEK-293T C234(0.91)  LDD1588  [16]
 LDCM0385  CL115 HEK-293T C234(1.02)  LDD1589  [16]
 LDCM0386  CL116 HEK-293T C234(1.16)  LDD1590  [16]
 LDCM0387  CL117 PaTu 8988t C234(1.38)  LDD1266  [17]
 LDCM0388  CL118 PaTu 8988t C234(1.05)  LDD1267  [17]
 LDCM0389  CL119 PaTu 8988t C234(1.39)  LDD1268  [17]
 LDCM0390  CL12 HEK-293T C234(1.04)  LDD1594  [16]
 LDCM0391  CL120 PaTu 8988t C234(1.39)  LDD1270  [17]
 LDCM0392  CL121 HEK-293T C234(1.07)  LDD1596  [16]
 LDCM0393  CL122 HEK-293T C234(0.95)  LDD1597  [16]
 LDCM0394  CL123 HEK-293T C234(0.88)  LDD1598  [16]
 LDCM0395  CL124 HEK-293T C234(0.88)  LDD1599  [16]
 LDCM0396  CL125 HEK-293T C234(0.93)  LDD1600  [16]
 LDCM0397  CL126 HEK-293T C234(0.98)  LDD1601  [16]
 LDCM0398  CL127 HEK-293T C234(1.01)  LDD1602  [16]
 LDCM0399  CL128 HEK-293T C234(1.07)  LDD1603  [16]
 LDCM0400  CL13 HEK-293T C234(0.98)  LDD1604  [16]
 LDCM0401  CL14 HEK-293T C234(1.04)  LDD1605  [16]
 LDCM0402  CL15 HEK-293T C234(0.93)  LDD1606  [16]
 LDCM0403  CL16 HEK-293T C234(1.15)  LDD1607  [16]
 LDCM0404  CL17 HEK-293T C234(0.95)  LDD1608  [16]
 LDCM0405  CL18 HEK-293T C234(1.12)  LDD1609  [16]
 LDCM0406  CL19 HEK-293T C234(1.00)  LDD1610  [16]
 LDCM0407  CL2 HEK-293T C234(0.99)  LDD1611  [16]
 LDCM0408  CL20 HEK-293T C234(1.20)  LDD1612  [16]
 LDCM0409  CL21 HEK-293T C234(1.31)  LDD1613  [16]
 LDCM0410  CL22 HEK-293T C234(1.10)  LDD1614  [16]
 LDCM0411  CL23 HEK-293T C234(1.15)  LDD1615  [16]
 LDCM0412  CL24 HEK-293T C234(1.08)  LDD1616  [16]
 LDCM0413  CL25 HEK-293T C234(0.93)  LDD1617  [16]
 LDCM0414  CL26 HEK-293T C234(0.98)  LDD1618  [16]
 LDCM0415  CL27 HEK-293T C234(1.02)  LDD1619  [16]
 LDCM0416  CL28 HEK-293T C234(1.03)  LDD1620  [16]
 LDCM0417  CL29 HEK-293T C234(1.17)  LDD1621  [16]
 LDCM0418  CL3 HEK-293T C234(0.92)  LDD1622  [16]
 LDCM0419  CL30 HEK-293T C234(1.07)  LDD1623  [16]
 LDCM0420  CL31 PaTu 8988t C234(1.21)  LDD1299  [17]
 LDCM0421  CL32 PaTu 8988t C234(1.29)  LDD1300  [17]
 LDCM0422  CL33 PaTu 8988t C234(1.43)  LDD1301  [17]
 LDCM0423  CL34 PaTu 8988t C234(1.57)  LDD1302  [17]
 LDCM0424  CL35 PaTu 8988t C234(1.65)  LDD1303  [17]
 LDCM0425  CL36 PaTu 8988t C234(1.69)  LDD1304  [17]
 LDCM0426  CL37 PaTu 8988t C234(1.38)  LDD1305  [17]
 LDCM0428  CL39 PaTu 8988t C234(1.61)  LDD1307  [17]
 LDCM0429  CL4 HEK-293T C234(1.05)  LDD1633  [16]
 LDCM0430  CL40 PaTu 8988t C234(1.10)  LDD1309  [17]
 LDCM0431  CL41 PaTu 8988t C234(1.30)  LDD1310  [17]
 LDCM0432  CL42 PaTu 8988t C234(1.26)  LDD1311  [17]
 LDCM0433  CL43 PaTu 8988t C234(1.36)  LDD1312  [17]
 LDCM0434  CL44 PaTu 8988t C234(1.44)  LDD1313  [17]
 LDCM0435  CL45 PaTu 8988t C234(1.89)  LDD1314  [17]
 LDCM0436  CL46 PaTu 8988t C234(0.90)  LDD1315  [17]
 LDCM0437  CL47 PaTu 8988t C234(1.14)  LDD1316  [17]
 LDCM0438  CL48 PaTu 8988t C234(1.05)  LDD1317  [17]
 LDCM0439  CL49 PaTu 8988t C234(1.55)  LDD1318  [17]
 LDCM0440  CL5 HEK-293T C234(1.06)  LDD1644  [16]
 LDCM0441  CL50 PaTu 8988t C234(0.89)  LDD1320  [17]
 LDCM0442  CL51 PaTu 8988t C234(1.28)  LDD1321  [17]
 LDCM0443  CL52 PaTu 8988t C234(1.60)  LDD1322  [17]
 LDCM0444  CL53 PaTu 8988t C234(1.66)  LDD1323  [17]
 LDCM0445  CL54 PaTu 8988t C234(1.44)  LDD1324  [17]
 LDCM0446  CL55 PaTu 8988t C234(1.01)  LDD1325  [17]
 LDCM0447  CL56 PaTu 8988t C234(0.98)  LDD1326  [17]
 LDCM0448  CL57 PaTu 8988t C234(1.18)  LDD1327  [17]
 LDCM0449  CL58 PaTu 8988t C234(1.08)  LDD1328  [17]
 LDCM0450  CL59 PaTu 8988t C234(0.91)  LDD1329  [17]
 LDCM0451  CL6 HEK-293T C234(1.00)  LDD1654  [16]
 LDCM0452  CL60 PaTu 8988t C234(1.12)  LDD1331  [17]
 LDCM0453  CL61 HEK-293T C234(0.99)  LDD1656  [16]
 LDCM0454  CL62 HEK-293T C234(1.03)  LDD1657  [16]
 LDCM0455  CL63 HEK-293T C234(1.04)  LDD1658  [16]
 LDCM0456  CL64 HEK-293T C234(1.09)  LDD1659  [16]
 LDCM0457  CL65 HEK-293T C234(1.14)  LDD1660  [16]
 LDCM0458  CL66 HEK-293T C234(1.10)  LDD1661  [16]
 LDCM0459  CL67 HEK-293T C234(1.05)  LDD1662  [16]
 LDCM0460  CL68 HEK-293T C234(1.47)  LDD1663  [16]
 LDCM0461  CL69 HEK-293T C234(1.14)  LDD1664  [16]
 LDCM0462  CL7 HEK-293T C234(1.02)  LDD1665  [16]
 LDCM0463  CL70 HEK-293T C234(1.12)  LDD1666  [16]
 LDCM0464  CL71 HEK-293T C234(1.03)  LDD1667  [16]
 LDCM0465  CL72 HEK-293T C234(1.12)  LDD1668  [16]
 LDCM0466  CL73 HEK-293T C234(1.02)  LDD1669  [16]
 LDCM0467  CL74 HEK-293T C234(1.16)  LDD1670  [16]
 LDCM0469  CL76 HEK-293T C234(1.05)  LDD1672  [16]
 LDCM0470  CL77 HEK-293T C234(1.03)  LDD1673  [16]
 LDCM0471  CL78 HEK-293T C234(1.09)  LDD1674  [16]
 LDCM0472  CL79 HEK-293T C234(0.90)  LDD1675  [16]
 LDCM0473  CL8 HEK-293T C234(0.88)  LDD1676  [16]
 LDCM0474  CL80 HEK-293T C234(1.06)  LDD1677  [16]
 LDCM0475  CL81 HEK-293T C234(1.10)  LDD1678  [16]
 LDCM0476  CL82 HEK-293T C234(1.03)  LDD1679  [16]
 LDCM0477  CL83 HEK-293T C234(1.01)  LDD1680  [16]
 LDCM0478  CL84 HEK-293T C234(1.14)  LDD1681  [16]
 LDCM0479  CL85 HEK-293T C234(0.93)  LDD1682  [16]
 LDCM0480  CL86 HEK-293T C234(0.92)  LDD1683  [16]
 LDCM0481  CL87 HEK-293T C234(0.96)  LDD1684  [16]
 LDCM0482  CL88 HEK-293T C234(0.99)  LDD1685  [16]
 LDCM0483  CL89 HEK-293T C234(1.01)  LDD1686  [16]
 LDCM0484  CL9 HEK-293T C234(0.91)  LDD1687  [16]
 LDCM0485  CL90 HEK-293T C234(0.85)  LDD1688  [16]
 LDCM0486  CL91 HEK-293T C234(0.94)  LDD1689  [16]
 LDCM0487  CL92 HEK-293T C234(1.09)  LDD1690  [16]
 LDCM0488  CL93 HEK-293T C234(1.07)  LDD1691  [16]
 LDCM0489  CL94 HEK-293T C234(1.05)  LDD1692  [16]
 LDCM0490  CL95 HEK-293T C234(0.94)  LDD1693  [16]
 LDCM0491  CL96 HEK-293T C234(0.90)  LDD1694  [16]
 LDCM0492  CL97 HEK-293T C234(0.98)  LDD1695  [16]
 LDCM0493  CL98 HEK-293T C234(0.97)  LDD1696  [16]
 LDCM0494  CL99 HEK-293T C234(1.14)  LDD1697  [16]
 LDCM0495  E2913 HEK-293T C234(1.14)  LDD1698  [16]
 LDCM0625  F8 Ramos C234(0.56)  LDD2187  [19]
 LDCM0573  Fragment11 Ramos C234(0.39)  LDD2190  [19]
 LDCM0576  Fragment14 Ramos C234(1.29)  LDD2193  [19]
 LDCM0586  Fragment28 Ramos C234(0.55)  LDD2198  [19]
 LDCM0468  Fragment33 HEK-293T C234(0.93)  LDD1671  [16]
 LDCM0427  Fragment51 PaTu 8988t C234(1.60)  LDD1306  [17]
 LDCM0569  Fragment7 Ramos C234(0.60)  LDD2186  [19]
 LDCM0116  HHS-0101 DM93 Y340(0.77)  LDD0264  [8]
 LDCM0117  HHS-0201 DM93 Y340(0.72)  LDD0265  [8]
 LDCM0118  HHS-0301 DM93 Y340(0.84)  LDD0266  [8]
 LDCM0119  HHS-0401 DM93 Y340(0.90)  LDD0267  [8]
 LDCM0120  HHS-0701 DM93 Y340(0.73)  LDD0268  [8]
 LDCM0022  KB02 HEK-293T C234(1.05)  LDD1492  [16]
 LDCM0023  KB03 HEK-293T C234(1.16)  LDD1497  [16]
 LDCM0024  KB05 SKMEL24 C234(1.71)  LDD3323  [5]
 LDCM0109  NEM HeLa N.A.  LDD0227  [9]
 LDCM0131  RA190 MM1.R C234(1.35)  LDD0304  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Acyl-CoA dehydrogenase family member 11 (ACAD11) Acyl-CoA dehydrogenase family Q709F0
Thioredoxin-like protein 4A (TXNL4A) DIM1 family P83876
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PPP1CA) PPP phosphatase family P62136
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PPP1CC) PPP phosphatase family P36873
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
T-cell surface antigen CD2 (CD2) . P06729
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Microtubule organization protein AKNA (AKNA) AKNA family Q7Z591
Proteasome inhibitor PI31 subunit (PSMF1) Proteasome inhibitor PI31 family Q92530
Small nuclear ribonucleoprotein-associated protein N (SNRPN) SnRNP SmB/SmN family P63162
Small nuclear ribonucleoprotein-associated proteins B and B' (SNRPB) SnRNP SmB/SmN family P14678
Melanoma-associated antigen D1 (MAGED1) . Q9Y5V3
Pre-mRNA-processing factor 6 (PRPF6) . O94906
WW domain-binding protein 11 (WBP11) . Q9Y2W2
Zinc finger HIT domain-containing protein 2 (ZNHIT2) . Q9UHR6

References

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Mass spectrometry data entry: PXD028270
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Mass spectrometry data entry: PXD047840
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Mass spectrometry data entry: PXD041264
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Mass spectrometry data entry: PXD044625
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Mass spectrometry data entry: PXD028853
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Mass spectrometry data entry: PXD031019
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Mass spectrometry data entry: PXD041587
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Mass spectrometry data entry: PXD044402
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Mass spectrometry data entry: PXD027578