Details of the Target

General Information of Target

Target ID LDTP03150
Target Name Methylmalonyl-CoA mutase, mitochondrial (MMUT)
Gene Name MMUT
Gene ID 4594
Synonyms
MUT; Methylmalonyl-CoA mutase, mitochondrial; MCM; EC 5.4.99.2; Methylmalonyl-CoA isomerase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLRAKNQLFLLSPHYLRQVKESSGSRLIQQRLLHQQQPLHPEWAALAKKQLKGKNPEDLI
WHTPEGISIKPLYSKRDTMDLPEELPGVKPFTRGPYPTMYTFRPWTIRQYAGFSTVEESN
KFYKDNIKAGQQGLSVAFDLATHRGYDSDNPRVRGDVGMAGVAIDTVEDTKILFDGIPLE
KMSVSMTMNGAVIPVLANFIVTGEEQGVPKEKLTGTIQNDILKEFMVRNTYIFPPEPSMK
IIADIFEYTAKHMPKFNSISISGYHMQEAGADAILELAYTLADGLEYSRTGLQAGLTIDE
FAPRLSFFWGIGMNFYMEIAKMRAGRRLWAHLIEKMFQPKNSKSLLLRAHCQTSGWSLTE
QDPYNNIVRTAIEAMAAVFGGTQSLHTNSFDEALGLPTVKSARIARNTQIIIQEESGIPK
VADPWGGSYMMECLTNDVYDAALKLINEIEEMGGMAKAVAEGIPKLRIEECAARRQARID
SGSEVIVGVNKYQLEKEDAVEVLAIDNTSVRNRQIEKLKKIKSSRDQALAERCLAALTEC
AASGDGNILALAVDASRARCTVGEITDALKKVFGEHKANDRMVSGAYRQEFGESKEITSA
IKRVHKFMEREGRRPRLLVAKMGQDGHDRGAKVIATGFADLGFDVDIGPLFQTPREVAQQ
AVDADVHAVGISTLAAGHKTLVPELIKELNSLGRPDILVMCGGVIPPQDYEFLFEVGVSN
VFGPGTRIPKAAVQVLDDIEKCLEKKQQSV
Target Type
Successful
Target Bioclass
Enzyme
Family
Methylmalonyl-CoA mutase family
Subcellular location
Mitochondrion matrix
Function
Catalyzes the reversible isomerization of methylmalonyl-CoA (MMCoA) (generated from branched-chain amino acid metabolism and degradation of dietary odd chain fatty acids and cholesterol) to succinyl-CoA (3-carboxypropionyl-CoA), a key intermediate of the tricarboxylic acid cycle.
TTD ID
T15569
Uniprot ID
P22033
DrugMap ID
TTCQ21Y
Ensemble ID
ENST00000274813.4
HGNC ID
HGNC:7526

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 23 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y587(20.00)  LDD0257  [1]
TH216
 Probe Info  		Y110(13.72)  LDD0259  [1]
STPyne
 Probe Info  		K223(1.04); K343(8.33); K621(6.78)  LDD0277  [2]
Probe 1
 Probe Info  		Y146(16.06); Y587(31.26)  LDD3495  [3]
DBIA
 Probe Info  		C433(1.25)  LDD3337  [4]
BTD
 Probe Info  		C471(1.18)  LDD2137  [5]
HHS-482
 Probe Info  		Y364(0.65)  LDD0286  [6]
HHS-475
 Probe Info  		Y364(2.61)  LDD0267  [7]
Acrolein
 Probe Info  		N.A.  LDD0222  [8]
5E-2FA
 Probe Info  		N.A.  LDD2235  [9]
ATP probe
 Probe Info  		K730(0.00); K741(0.00); K745(0.00)  LDD0199  [10]
1d-yne
 Probe Info  		N.A.  LDD0358  [11]
CY4
 Probe Info  		K457(0.00); M452(0.00); M455(0.00)  LDD0247  [12]
4-Iodoacetamidophenylacetylene
 Probe Info  		C351(0.00); C560(0.00); C471(0.00); C433(0.00)  LDD0038  [13]
IA-alkyne
 Probe Info  		C433(0.00); C351(0.00)  LDD0032  [14]
Lodoacetamide azide
 Probe Info  		C351(0.00); C560(0.00); C471(0.00); C433(0.00)  LDD0037  [13]
IPM
 Probe Info  		N.A.  LDD0147  [15]
NPM
 Probe Info  		N.A.  LDD0016  [16]
TFBX
 Probe Info  		N.A.  LDD0148  [15]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [8]
W1
 Probe Info  		N.A.  LDD0236  [17]
NAIA_5
 Probe Info  		C742(0.00); C560(0.00)  LDD2223  [18]
HHS-465
 Probe Info  		N.A.  LDD2240  [19]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C027
 Probe Info  		11.39  LDD1733  [20]
C094
 Probe Info  		26.17  LDD1785  [20]
C158
 Probe Info  		9.06  LDD1838  [20]
C347
 Probe Info  		5.62  LDD2008  [20]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C560(0.98); C540(0.80)  LDD1507  [21]
 LDCM0215  AC10 HEK-293T C560(0.98); C433(0.98); C540(0.99)  LDD1508  [21]
 LDCM0226  AC11 HEK-293T C540(1.07)  LDD1509  [21]
 LDCM0237  AC12 HEK-293T C560(0.99); C351(1.00); C540(1.06)  LDD1510  [21]
 LDCM0259  AC14 HEK-293T C560(0.98); C433(0.69); C351(0.94); C540(1.16)  LDD1512  [21]
 LDCM0270  AC15 HEK-293T C560(1.01); C540(0.88)  LDD1513  [21]
 LDCM0276  AC17 HEK-293T C560(0.89); C540(0.91)  LDD1515  [21]
 LDCM0277  AC18 HEK-293T C560(0.95); C433(1.03); C540(1.00)  LDD1516  [21]
 LDCM0278  AC19 HEK-293T C540(0.75)  LDD1517  [21]
 LDCM0279  AC2 HEK-293T C560(0.95); C433(1.01); C540(0.95)  LDD1518  [21]
 LDCM0280  AC20 HEK-293T C560(1.02); C351(0.98); C540(1.02)  LDD1519  [21]
 LDCM0281  AC21 HEK-293T C560(1.01); C351(1.04); C540(1.17)  LDD1520  [21]
 LDCM0282  AC22 HEK-293T C560(1.02); C433(0.66); C351(1.09); C540(0.92)  LDD1521  [21]
 LDCM0283  AC23 HEK-293T C560(1.04); C540(0.86)  LDD1522  [21]
 LDCM0284  AC24 HEK-293T C560(0.96); C540(0.85)  LDD1523  [21]
 LDCM0285  AC25 HEK-293T C560(0.93); C540(0.92)  LDD1524  [21]
 LDCM0286  AC26 HEK-293T C560(1.03); C433(0.90); C540(0.88)  LDD1525  [21]
 LDCM0287  AC27 HEK-293T C540(0.91)  LDD1526  [21]
 LDCM0288  AC28 HEK-293T C560(1.01); C351(1.06); C540(1.29)  LDD1527  [21]
 LDCM0289  AC29 HEK-293T C560(1.04); C351(1.35); C540(1.13)  LDD1528  [21]
 LDCM0290  AC3 HEK-293T C540(1.03)  LDD1529  [21]
 LDCM0291  AC30 HEK-293T C560(1.01); C433(0.77); C351(1.18); C540(0.83)  LDD1530  [21]
 LDCM0292  AC31 HEK-293T C560(1.04); C540(0.87)  LDD1531  [21]
 LDCM0293  AC32 HEK-293T C560(0.90); C540(1.04)  LDD1532  [21]
 LDCM0294  AC33 HEK-293T C560(0.91); C540(0.97)  LDD1533  [21]
 LDCM0295  AC34 HEK-293T C560(0.95); C433(1.24); C540(1.14)  LDD1534  [21]
 LDCM0296  AC35 HEK-293T C540(1.19)  LDD1535  [21]
 LDCM0297  AC36 HEK-293T C560(0.94); C351(1.02); C540(1.03)  LDD1536  [21]
 LDCM0298  AC37 HEK-293T C560(1.11); C351(1.74); C540(1.07)  LDD1537  [21]
 LDCM0299  AC38 HEK-293T C560(1.02); C433(0.81); C351(1.25); C540(1.08)  LDD1538  [21]
 LDCM0300  AC39 HEK-293T C560(1.14); C540(1.00)  LDD1539  [21]
 LDCM0301  AC4 HEK-293T C560(0.92); C351(0.87); C540(1.06)  LDD1540  [21]
 LDCM0302  AC40 HEK-293T C560(0.90); C540(1.04)  LDD1541  [21]
 LDCM0303  AC41 HEK-293T C560(0.83); C540(1.03)  LDD1542  [21]
 LDCM0304  AC42 HEK-293T C560(0.89); C433(0.89); C540(0.95)  LDD1543  [21]
 LDCM0305  AC43 HEK-293T C540(0.96)  LDD1544  [21]
 LDCM0306  AC44 HEK-293T C560(1.01); C351(0.84); C540(1.23)  LDD1545  [21]
 LDCM0307  AC45 HEK-293T C560(1.08); C351(1.10); C540(1.16)  LDD1546  [21]
 LDCM0308  AC46 HEK-293T C560(1.00); C433(0.79); C351(1.00); C540(1.01)  LDD1547  [21]
 LDCM0309  AC47 HEK-293T C560(1.11); C540(0.84)  LDD1548  [21]
 LDCM0310  AC48 HEK-293T C560(0.93); C540(1.08)  LDD1549  [21]
 LDCM0311  AC49 HEK-293T C560(0.93); C540(1.08)  LDD1550  [21]
 LDCM0312  AC5 HEK-293T C560(1.03); C351(1.11); C540(1.14)  LDD1551  [21]
 LDCM0313  AC50 HEK-293T C560(0.95); C433(0.97); C540(1.02)  LDD1552  [21]
 LDCM0314  AC51 HEK-293T C540(1.15)  LDD1553  [21]
 LDCM0315  AC52 HEK-293T C560(0.97); C351(1.13); C540(1.13)  LDD1554  [21]
 LDCM0316  AC53 HEK-293T C560(1.01); C351(1.04); C540(0.96)  LDD1555  [21]
 LDCM0317  AC54 HEK-293T C560(1.00); C433(0.84); C351(1.02); C540(1.01)  LDD1556  [21]
 LDCM0318  AC55 HEK-293T C560(1.17); C540(0.97)  LDD1557  [21]
 LDCM0319  AC56 HEK-293T C560(0.94); C540(0.94)  LDD1558  [21]
 LDCM0320  AC57 HEK-293T C560(0.83); C540(0.81)  LDD1559  [21]
 LDCM0321  AC58 HEK-293T C560(0.82); C433(0.94); C540(1.00)  LDD1560  [21]
 LDCM0322  AC59 HEK-293T C540(0.80)  LDD1561  [21]
 LDCM0323  AC6 HEK-293T C560(0.96); C433(1.11); C351(1.35); C540(0.95)  LDD1562  [21]
 LDCM0324  AC60 HEK-293T C560(0.89); C351(1.07); C540(0.97)  LDD1563  [21]
 LDCM0325  AC61 HEK-293T C560(0.94); C351(1.39); C540(1.06)  LDD1564  [21]
 LDCM0326  AC62 HEK-293T C560(0.89); C433(1.13); C351(1.02); C540(0.91)  LDD1565  [21]
 LDCM0327  AC63 HEK-293T C560(1.02); C540(0.94)  LDD1566  [21]
 LDCM0328  AC64 HEK-293T C560(0.95); C540(1.11)  LDD1567  [21]
 LDCM0334  AC7 HEK-293T C560(0.99); C540(0.85)  LDD1568  [21]
 LDCM0345  AC8 HEK-293T C560(0.94); C540(0.92)  LDD1569  [21]
 LDCM0248  AKOS034007472 HEK-293T C560(1.04); C351(1.24); C540(1.17)  LDD1511  [21]
 LDCM0356  AKOS034007680 HEK-293T C560(0.90); C540(0.90)  LDD1570  [21]
 LDCM0275  AKOS034007705 HEK-293T C560(1.08); C540(0.90)  LDD1514  [21]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [8]
 LDCM0367  CL1 HEK-293T C560(0.93)  LDD1571  [21]
 LDCM0368  CL10 HEK-293T C560(1.18); C433(0.70); C351(1.39); C540(1.03)  LDD1572  [21]
 LDCM0369  CL100 HEK-293T C560(1.07); C351(0.76); C540(1.19)  LDD1573  [21]
 LDCM0370  CL101 HEK-293T C560(1.00)  LDD1574  [21]
 LDCM0371  CL102 HEK-293T C560(0.89); C540(0.92)  LDD1575  [21]
 LDCM0372  CL103 HEK-293T C560(0.96); C540(1.06)  LDD1576  [21]
 LDCM0373  CL104 HEK-293T C560(1.05); C351(0.88); C540(1.32)  LDD1577  [21]
 LDCM0374  CL105 HEK-293T C560(0.94)  LDD1578  [21]
 LDCM0375  CL106 HEK-293T C560(0.97); C540(0.93)  LDD1579  [21]
 LDCM0376  CL107 HEK-293T C560(0.97); C540(0.88)  LDD1580  [21]
 LDCM0377  CL108 HEK-293T C560(1.00); C351(0.99); C540(1.22)  LDD1581  [21]
 LDCM0378  CL109 HEK-293T C560(1.05)  LDD1582  [21]
 LDCM0379  CL11 HEK-293T C560(1.19); C540(0.87)  LDD1583  [21]
 LDCM0380  CL110 HEK-293T C560(0.95); C540(0.64)  LDD1584  [21]
 LDCM0381  CL111 HEK-293T C560(0.94); C540(0.80)  LDD1585  [21]
 LDCM0382  CL112 HEK-293T C560(0.98); C351(0.85); C540(0.86)  LDD1586  [21]
 LDCM0383  CL113 HEK-293T C560(0.90)  LDD1587  [21]
 LDCM0384  CL114 HEK-293T C560(1.01); C540(0.94)  LDD1588  [21]
 LDCM0385  CL115 HEK-293T C560(0.99); C540(1.13)  LDD1589  [21]
 LDCM0386  CL116 HEK-293T C560(0.99); C351(0.87); C540(1.04)  LDD1590  [21]
 LDCM0387  CL117 HEK-293T C560(0.95)  LDD1591  [21]
 LDCM0388  CL118 HEK-293T C560(1.02); C540(1.01)  LDD1592  [21]
 LDCM0389  CL119 HEK-293T C560(1.04); C540(0.98)  LDD1593  [21]
 LDCM0390  CL12 HEK-293T C560(1.06); C540(0.98)  LDD1594  [21]
 LDCM0391  CL120 HEK-293T C560(1.00); C351(0.92); C540(1.04)  LDD1595  [21]
 LDCM0392  CL121 HEK-293T C560(1.00)  LDD1596  [21]
 LDCM0393  CL122 HEK-293T C560(1.01); C540(0.99)  LDD1597  [21]
 LDCM0394  CL123 HEK-293T C560(0.78); C540(1.16)  LDD1598  [21]
 LDCM0395  CL124 HEK-293T C560(1.03); C351(0.95); C540(1.06)  LDD1599  [21]
 LDCM0396  CL125 HEK-293T C560(0.87)  LDD1600  [21]
 LDCM0397  CL126 HEK-293T C560(0.94); C540(0.97)  LDD1601  [21]
 LDCM0398  CL127 HEK-293T C560(0.92); C540(0.90)  LDD1602  [21]
 LDCM0399  CL128 HEK-293T C560(0.95); C351(0.97); C540(1.04)  LDD1603  [21]
 LDCM0400  CL13 HEK-293T C560(0.97)  LDD1604  [21]
 LDCM0401  CL14 HEK-293T C560(1.06); C540(1.17)  LDD1605  [21]
 LDCM0402  CL15 HEK-293T C560(0.94); C540(0.88)  LDD1606  [21]
 LDCM0403  CL16 HEK-293T C560(1.21); C351(0.88); C540(1.13)  LDD1607  [21]
 LDCM0404  CL17 HEK-293T C560(0.89); C540(0.85)  LDD1608  [21]
 LDCM0405  CL18 HEK-293T C560(1.04); C433(0.95); C540(1.06)  LDD1609  [21]
 LDCM0406  CL19 HEK-293T C540(1.07)  LDD1610  [21]
 LDCM0407  CL2 HEK-293T C560(1.14); C540(0.96)  LDD1611  [21]
 LDCM0408  CL20 HEK-293T C560(1.20); C351(1.01); C540(1.09)  LDD1612  [21]
 LDCM0409  CL21 HEK-293T C560(1.29); C351(1.46); C540(0.83)  LDD1613  [21]
 LDCM0410  CL22 HEK-293T C560(1.36); C433(0.77); C351(1.49); C540(1.17)  LDD1614  [21]
 LDCM0411  CL23 HEK-293T C560(1.27); C540(0.96)  LDD1615  [21]
 LDCM0412  CL24 HEK-293T C560(1.40); C540(1.09)  LDD1616  [21]
 LDCM0413  CL25 HEK-293T C560(0.89)  LDD1617  [21]
 LDCM0414  CL26 HEK-293T C560(1.00); C540(1.07)  LDD1618  [21]
 LDCM0415  CL27 HEK-293T C560(1.02); C540(1.11)  LDD1619  [21]
 LDCM0416  CL28 HEK-293T C560(1.08); C351(0.84); C540(0.73)  LDD1620  [21]
 LDCM0417  CL29 HEK-293T C560(0.97); C540(1.04)  LDD1621  [21]
 LDCM0418  CL3 HEK-293T C560(1.00); C540(0.78)  LDD1622  [21]
 LDCM0419  CL30 HEK-293T C560(1.06); C433(2.39); C540(1.04)  LDD1623  [21]
 LDCM0420  CL31 HEK-293T C540(0.93)  LDD1624  [21]
 LDCM0421  CL32 HEK-293T C560(1.27); C351(1.23); C540(1.05)  LDD1625  [21]
 LDCM0422  CL33 HEK-293T C560(1.28); C351(1.17); C540(1.06)  LDD1626  [21]
 LDCM0423  CL34 HEK-293T C560(1.32); C433(1.05); C351(1.45); C540(1.07)  LDD1627  [21]
 LDCM0424  CL35 HEK-293T C560(1.17); C540(0.96)  LDD1628  [21]
 LDCM0425  CL36 HEK-293T C560(1.23); C540(0.95)  LDD1629  [21]
 LDCM0426  CL37 HEK-293T C560(0.94)  LDD1630  [21]
 LDCM0428  CL39 HEK-293T C560(0.93); C540(1.06)  LDD1632  [21]
 LDCM0429  CL4 HEK-293T C560(1.05); C351(0.60); C540(1.00)  LDD1633  [21]
 LDCM0430  CL40 HEK-293T C560(1.01); C351(1.02); C540(1.07)  LDD1634  [21]
 LDCM0431  CL41 HEK-293T C560(0.94); C540(0.94)  LDD1635  [21]
 LDCM0432  CL42 HEK-293T C560(1.09); C433(0.76); C540(1.02)  LDD1636  [21]
 LDCM0433  CL43 HEK-293T C540(0.86)  LDD1637  [21]
 LDCM0434  CL44 HEK-293T C560(1.17); C351(1.08); C540(0.91)  LDD1638  [21]
 LDCM0435  CL45 HEK-293T C560(1.16); C351(1.18); C540(0.93)  LDD1639  [21]
 LDCM0436  CL46 HEK-293T C560(1.28); C433(0.71); C351(1.06); C540(1.15)  LDD1640  [21]
 LDCM0437  CL47 HEK-293T C560(1.20); C540(0.89)  LDD1641  [21]
 LDCM0438  CL48 HEK-293T C560(1.51); C540(1.07)  LDD1642  [21]
 LDCM0439  CL49 HEK-293T C560(0.93)  LDD1643  [21]
 LDCM0440  CL5 HEK-293T C560(1.00); C540(1.14)  LDD1644  [21]
 LDCM0441  CL50 HEK-293T C560(1.02); C540(0.92)  LDD1645  [21]
 LDCM0443  CL52 HEK-293T C560(1.03); C351(1.09); C540(0.92)  LDD1646  [21]
 LDCM0444  CL53 HEK-293T C560(0.98); C540(0.93)  LDD1647  [21]
 LDCM0445  CL54 HEK-293T C560(1.11); C433(0.95); C540(0.79)  LDD1648  [21]
 LDCM0446  CL55 HEK-293T C540(1.12)  LDD1649  [21]
 LDCM0447  CL56 HEK-293T C560(1.27); C351(1.07); C540(1.07)  LDD1650  [21]
 LDCM0448  CL57 HEK-293T C560(1.27); C351(1.53); C540(1.10)  LDD1651  [21]
 LDCM0449  CL58 HEK-293T C560(1.28); C433(0.94); C351(1.22); C540(1.07)  LDD1652  [21]
 LDCM0450  CL59 HEK-293T C560(1.41); C540(0.93)  LDD1653  [21]
 LDCM0451  CL6 HEK-293T C560(0.95); C433(1.06); C540(0.95)  LDD1654  [21]
 LDCM0452  CL60 HEK-293T C560(1.52); C540(0.92)  LDD1655  [21]
 LDCM0453  CL61 HEK-293T C560(0.86)  LDD1656  [21]
 LDCM0454  CL62 HEK-293T C560(1.15); C540(0.94)  LDD1657  [21]
 LDCM0455  CL63 HEK-293T C560(0.95); C540(0.92)  LDD1658  [21]
 LDCM0456  CL64 HEK-293T C560(1.05); C351(0.68); C540(1.00)  LDD1659  [21]
 LDCM0457  CL65 HEK-293T C560(0.95); C540(1.04)  LDD1660  [21]
 LDCM0458  CL66 HEK-293T C560(0.94); C433(1.07); C540(0.93)  LDD1661  [21]
 LDCM0459  CL67 HEK-293T C540(1.18)  LDD1662  [21]
 LDCM0460  CL68 HEK-293T C560(1.20); C351(1.19); C540(0.97)  LDD1663  [21]
 LDCM0461  CL69 HEK-293T C560(1.27); C351(1.42); C540(1.10)  LDD1664  [21]
 LDCM0462  CL7 HEK-293T C540(1.10)  LDD1665  [21]
 LDCM0463  CL70 HEK-293T C560(1.29); C433(0.89); C351(1.45); C540(1.10)  LDD1666  [21]
 LDCM0464  CL71 HEK-293T C560(1.29); C540(0.83)  LDD1667  [21]
 LDCM0465  CL72 HEK-293T C560(1.37); C540(0.91)  LDD1668  [21]
 LDCM0466  CL73 HEK-293T C560(0.98)  LDD1669  [21]
 LDCM0467  CL74 HEK-293T C560(1.03); C540(1.04)  LDD1670  [21]
 LDCM0469  CL76 HEK-293T C560(1.11); C351(0.79); C540(1.34)  LDD1672  [21]
 LDCM0470  CL77 HEK-293T C560(0.91); C540(0.92)  LDD1673  [21]
 LDCM0471  CL78 HEK-293T C560(1.00); C433(1.13); C540(0.94)  LDD1674  [21]
 LDCM0472  CL79 HEK-293T C540(0.96)  LDD1675  [21]
 LDCM0473  CL8 HEK-293T C560(0.94); C351(1.01); C540(1.01)  LDD1676  [21]
 LDCM0474  CL80 HEK-293T C560(1.24); C351(1.44); C540(1.20)  LDD1677  [21]
 LDCM0475  CL81 HEK-293T C560(1.24); C351(1.40); C540(1.24)  LDD1678  [21]
 LDCM0476  CL82 HEK-293T C560(1.24); C433(0.90); C351(1.50); C540(1.27)  LDD1679  [21]
 LDCM0477  CL83 HEK-293T C560(1.37); C540(1.08)  LDD1680  [21]
 LDCM0478  CL84 HEK-293T C560(1.23); C540(0.89)  LDD1681  [21]
 LDCM0479  CL85 HEK-293T C560(0.90)  LDD1682  [21]
 LDCM0480  CL86 HEK-293T C560(1.03); C540(0.85)  LDD1683  [21]
 LDCM0481  CL87 HEK-293T C560(0.85); C540(0.94)  LDD1684  [21]
 LDCM0482  CL88 HEK-293T C560(0.99); C351(0.99); C540(0.86)  LDD1685  [21]
 LDCM0483  CL89 HEK-293T C560(0.87); C540(1.10)  LDD1686  [21]
 LDCM0484  CL9 HEK-293T C560(1.54); C351(1.48); C540(1.29)  LDD1687  [21]
 LDCM0485  CL90 HEK-293T C560(0.87); C433(0.94); C540(0.82)  LDD1688  [21]
 LDCM0486  CL91 HEK-293T C540(0.84)  LDD1689  [21]
 LDCM0487  CL92 HEK-293T C560(0.96); C351(0.94); C540(1.06)  LDD1690  [21]
 LDCM0488  CL93 HEK-293T C560(1.43); C351(1.04); C540(0.85)  LDD1691  [21]
 LDCM0489  CL94 HEK-293T C560(1.11); C433(0.69); C351(1.23); C540(1.03)  LDD1692  [21]
 LDCM0490  CL95 HEK-293T C560(1.14); C540(0.86)  LDD1693  [21]
 LDCM0491  CL96 HEK-293T C560(0.91); C540(0.70)  LDD1694  [21]
 LDCM0492  CL97 HEK-293T C560(0.92)  LDD1695  [21]
 LDCM0493  CL98 HEK-293T C560(0.99); C540(1.08)  LDD1696  [21]
 LDCM0494  CL99 HEK-293T C560(0.95); C540(1.01)  LDD1697  [21]
 LDCM0495  E2913 HEK-293T C560(0.93); C540(0.88)  LDD1698  [21]
 LDCM0468  Fragment33 HEK-293T C560(0.96); C540(1.05)  LDD1671  [21]
 LDCM0427  Fragment51 HEK-293T C560(1.11); C540(0.95)  LDD1631  [21]
 LDCM0119  HHS-0401 DM93 Y364(2.61)  LDD0267  [7]
 LDCM0124  JWB142 DM93 Y364(0.65)  LDD0286  [6]
 LDCM0127  JWB152 DM93 Y364(1.13)  LDD0289  [6]
 LDCM0130  JWB211 DM93 Y364(1.23)  LDD0292  [6]
 LDCM0022  KB02 HEK-293T C351(0.95)  LDD1492  [21]
 LDCM0023  KB03 HEK-293T C351(0.96)  LDD1497  [21]
 LDCM0024  KB05 MSTO-211H C433(1.25)  LDD3337  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C471(1.18)  LDD2137  [5]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C471(0.61)  LDD2141  [5]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C471(0.37)  LDD2145  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Methylmalonyl-CoA mutase, mitochondrial (MMUT) Methylmalonyl-CoA mutase family P22033
Methylmalonic aciduria type A protein, mitochondrial (MMAA) SIMIBI class G3E GTPase family Q8IVH4
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Cyanocobalamin Small molecular drug DB00115
Hydroxocobalamin Small molecular drug D0VF4H
Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Mrna-3704 mRNA therapy DJN3E2

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
7 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
8 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
9 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
10 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
11 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
12 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
13 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
14 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
15 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
16 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
17 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
18 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
19 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
20 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
21 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402