Details of the Target

General Information of Target

Target ID LDTP00009
Target Name RNA-binding protein 47 (RBM47)
Gene Name RBM47
Gene ID 54502
Synonyms
RNA-binding protein 47; RNA-binding motif protein 47
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MTAEDSTAAMSSDSAAGSSAKVPEGVAGAPNEAALLALMERTGYSMVQENGQRKYGGPPP
GWEGPHPQRGCEVFVGKIPRDVYEDELVPVFEAVGRIYELRLMMDFDGKNRGYAFVMYCH
KHEAKRAVRELNNYEIRPGRLLGVCCSVDNCRLFIGGIPKMKKREEILEEIAKVTEGVLD
VIVYASAADKMKNRGFAFVEYESHRAAAMARRKLMPGRIQLWGHQIAVDWAEPEIDVDED
VMETVKILYVRNLMIETTEDTIKKSFGQFNPGCVERVKKIRDYAFVHFTSREDAVHAMNN
LNGTELEGSCLEVTLAKPVDKEQYSRYQKAARGGGAAEAAQQPSYVYSCDPYTLAYYGYP
YNALIGPNRDYFVKAGSIRGRGRGAAGNRAPGPRGSYLGGYSAGRGIYSRYHEGKGKQQE
KGYELVPNLEIPTVNPVAIKPGTVAIPAIGAQYSMFPAAPAPKMIEDGKIHTVEHMISPI
AVQPDPASAAAAAAAAAAAAAAVIPTVSTPPPFQGRPITPVYTVAPNVQRIPTAGIYGAS
YVPFAAPATATIATLQKNAAAAAAMYGGYAGYIPQAFPAAAIQVPIPDVYQTY
Target Bioclass
Other
Family
RRM RBM47 family
Subcellular location
Nucleus
Function
Single-stranded RNA-binding protein that functions in a variety of RNA processes, including alternative splicing, RNA stabilization, and RNA editing . Functions as an enzyme-substrate adapter for the cytidine deaminase APOBEC1. With APOBEC1 forms an mRNA editing complex involved into cytidine to uridine editing of a variety of mRNA molecules. Through the binding of their 3'UTR, also stabilizes a variety of mRNAs and regulates the expression of genes such as the interferon alpha/beta receptor and interleukin-10. Also involved in the alternative splicing of several genes including TJP1. Binds the pre-mRNA (U)GCAUG consensus sequences in downstream intronic regions of alternative exons, regulating their exclusion and inclusion into mRNAs. Independently of its RNA-binding activity, could negatively regulate MAVS by promoting its lysosomal degradation.
Uniprot ID
A0AV96
Ensemble ID
ENST00000295971.12
HGNC ID
HGNC:30358

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CHL1 SNV: p.A560P .
HCT15 SNV: p.A501V DBIA    Probe Info 
HEC1 SNV: p.R164H; p.A331V .
HEC1B SNV: p.R164H .
HT1376 SNV: p.E338K .
J82 Deletion: p.A501_A502del .
MFE319 SNV: p.G61V .
PC3 SNV: p.R137H .
RKO Deletion: p.A375QfsTer4 .
SHP77 SNV: p.R381G .
SISO Insertion: p.V313CfsTer26 .
SKMEL30 SNV: p.G400E .
SKOV3 SNV: p.R251H DBIA    Probe Info 
SNU1 SNV: p.R405C .
YSCCC SNV: p.R101H DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K329(2.14); K415(6.79)  LDD0277  [1]
IPM
 Probe Info  		N.A.  LDD0241  [2]
AHL-Pu-1
 Probe Info  		C349(5.03)  LDD0168  [3]
HPAP
 Probe Info  		5.15  LDD0063  [4]
DBIA
 Probe Info  		C349(1.05)  LDD0078  [5]
IA-alkyne
 Probe Info  		C349(0.00); C310(0.00); C71(0.00); C273(0.00)  LDD0162  [6]
NAIA_4
 Probe Info  		N.A.  LDD2226  [7]
WYneN
 Probe Info  		N.A.  LDD0021  [8]
WYneO
 Probe Info  		N.A.  LDD0022  [8]
Acrolein
 Probe Info  		N.A.  LDD0217  [9]
NAIA_5
 Probe Info  		C71(0.00); C119(0.00)  LDD2223  [7]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C347
 Probe Info  		5.24  LDD2008  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C349(5.03)  LDD0168  [3]
 LDCM0026  4SU-RNA+native RNA HEK-293T C349(7.10)  LDD0169  [3]
 LDCM0214  AC1 HCT 116 C145(1.05); C146(1.05); C273(1.04)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C145(1.01); C151(1.03)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C145(0.51); C151(0.51); C273(0.88)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C145(0.49); C151(0.49); C273(0.79)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C145(0.51); C151(0.51); C273(0.79)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C145(0.24); C151(0.24); C273(0.66)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C145(0.30); C151(0.30); C273(0.78)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C145(0.30); C151(0.30); C273(0.70)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C145(0.30); C151(0.30); C273(0.68)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C145(0.38); C151(0.56); C273(0.81)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C145(0.61); C151(0.43); C273(0.68)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C145(0.50); C151(0.35); C273(0.81)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C145(1.06); C151(1.13)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C145(0.52); C151(0.38); C273(0.72)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C145(0.45); C151(0.38); C273(0.66)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C145(0.39); C151(0.48); C273(0.74)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C273(1.05)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C273(1.14)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C273(0.93)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C273(1.15)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C273(0.99)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C273(1.05)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C273(1.30)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C145(1.03); C151(1.04)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C273(1.31)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C273(1.08)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C273(1.23)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C273(1.38)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C273(1.22)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C273(1.29)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C273(1.19)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C273(1.11)  LDD0562  [5]
 LDCM0259  AC14 HCT 116 C145(0.97); C151(1.05)  LDD0576  [5]
 LDCM0263  AC143 HCT 116 C145(0.99); C151(0.99); C146(1.01); C273(1.26)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C273(0.59); C145(0.77); C151(0.77); C146(1.24)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C145(0.94); C151(0.94); C273(1.02); C146(1.31)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C273(0.94); C145(1.05); C151(1.05); C146(1.33)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C273(0.59); C145(0.84); C151(0.84); C146(1.26)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C273(0.51); C145(0.82); C151(0.82); C146(1.09)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C273(0.56); C145(0.71); C151(0.71); C146(1.01)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C145(1.01); C151(1.06)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C145(0.95); C151(0.95); C273(1.17); C146(1.20)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C273(0.92); C145(1.02); C151(1.02); C146(1.25)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C273(0.46); C145(0.78); C151(0.78); C146(1.09)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C273(0.58); C145(0.97); C151(0.97); C146(1.21)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C145(0.88); C146(1.09); C151(0.88); C273(0.71)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C145(0.94); C146(1.31); C151(0.94); C273(0.68)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C145(1.21); C146(1.32); C151(1.21); C273(1.10)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C145(0.97); C146(1.43); C151(0.97); C273(0.97)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C273(0.76); C146(0.86); C145(0.89); C151(0.89)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C273(0.33); C145(0.52); C151(0.52); C146(1.12)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C273(0.72); C145(0.73); C151(0.73); C146(1.12)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C145(1.08); C146(1.08); C273(1.22)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C273(0.70); C145(0.85); C151(0.85); C146(1.00)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C273(0.65); C145(0.83); C151(0.83); C146(0.90)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C273(0.83); C145(0.96); C151(0.96); C146(1.05)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C273(0.71); C146(0.86); C145(1.07); C151(1.07)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C273(0.85); C145(1.00); C151(1.00); C146(1.20)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C273(1.00)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C273(1.04)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C273(0.87)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C273(0.90)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C273(1.02)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C273(1.04); C145(1.64); C146(1.64)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C273(0.96)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C273(0.90)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C273(0.83)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C273(0.71)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C273(0.65)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C146(0.76); C145(1.19); C151(1.27); C273(1.49)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C146(0.83); C273(1.18); C145(1.24); C151(1.26)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C146(0.71); C145(1.03); C273(1.11); C151(1.14)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C146(1.03); C145(1.10); C273(1.11); C151(1.11)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C146(0.89); C145(0.96); C273(0.98); C151(1.01)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C273(0.69); C145(1.39); C146(1.39)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C273(0.79); C146(0.88); C145(0.96); C151(1.04)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C273(1.27); C146(1.28); C151(1.28); C145(1.31)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C273(0.96); C146(1.20); C145(1.26); C151(1.29)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C273(1.10); C151(1.35); C145(1.61); C146(2.36)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C146(0.67); C273(0.80); C145(0.95); C151(1.04)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C146(0.70); C273(0.77); C145(0.83); C151(0.87)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C146(1.04); C145(1.11); C273(1.13); C151(1.17)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C273(0.93); C145(0.95); C151(0.97); C146(0.98)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C146(0.90); C145(1.05); C151(1.13); C273(1.49)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C273(0.67); C151(0.92); C145(0.97); C146(1.18)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C273(0.94); C145(1.44); C146(1.44)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C273(0.62); C151(0.78); C145(0.83); C146(0.95)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C146(1.06); C145(1.22); C151(1.33); C273(1.90)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C273(0.88); C146(0.96); C145(0.99); C151(1.05)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C273(0.70); C151(0.85); C145(0.87); C146(1.01)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C151(0.64); C273(0.67); C145(0.71); C146(0.89)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C273(0.65); C151(0.76); C145(0.86); C146(1.16)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C273(0.71); C146(0.98); C145(1.16); C151(1.31)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C273(0.54); C151(0.61); C145(0.67); C146(0.73)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C151(0.53); C273(0.61); C145(0.61); C146(0.70)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C151(0.46); C273(0.59); C145(0.61); C146(0.75)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C151(0.93); C145(0.95)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C273(0.66); C151(0.68); C145(0.70); C146(0.73)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C146(0.69); C145(0.72); C151(0.75); C273(1.05)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C151(0.53); C145(0.59); C273(0.63); C146(0.65)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C273(0.64); C146(0.65); C145(0.65); C151(0.65)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C151(0.46); C273(0.55); C145(0.56); C146(0.66)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C151(0.50); C273(0.63); C145(0.67); C146(0.84)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C151(0.53); C273(0.64); C145(0.70); C146(0.86)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C273(0.48); C151(0.66); C145(0.72); C146(0.77)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C151(0.68); C145(0.72); C146(0.85); C273(0.90)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C151(0.69); C273(0.72); C145(0.74); C146(0.88)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C145(0.98); C151(0.99)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C273(0.66); C151(0.69); C145(0.75); C146(0.83)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C151(0.84); C145(0.98); C146(1.02); C273(1.10)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C273(0.64); C151(0.68); C145(0.88); C146(1.14)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C273(0.72); C151(0.91); C146(1.11); C145(1.12)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C273(0.79); C151(0.90); C145(1.14); C146(1.14)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C273(0.77); C146(0.88); C151(1.05); C145(1.09)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C151(0.66); C273(0.66); C145(0.68); C146(0.88)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C151(0.61); C273(0.66); C145(0.74); C146(0.88)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C151(0.85); C146(0.92); C145(0.95); C273(1.15)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C151(0.75); C145(0.81); C273(0.89); C146(0.89)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C145(0.90); C151(0.93)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C151(0.67); C273(0.73); C145(0.74); C146(0.86)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C273(1.01); C146(1.02); C151(1.33); C145(1.44)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C273(0.92); C146(0.99); C151(1.60); C145(1.68)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C273(0.37); C145(0.82); C151(0.82)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C273(0.39); C145(0.81); C151(0.81)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C273(0.52); C145(0.97); C151(0.97)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C273(0.45); C145(0.88); C151(0.88)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C273(0.75); C145(0.93); C151(0.93)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C273(0.55); C145(0.79); C151(0.79)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C273(0.37); C145(0.70); C151(0.70)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C273(0.92); C145(0.95); C151(0.95)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C273(0.41); C145(0.72); C151(0.72)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C273(0.35); C145(0.70); C151(0.70)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C273(0.56); C145(0.77); C151(0.77)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C273(0.57); C145(0.95); C151(0.95)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C273(0.82); C145(0.98); C151(0.98)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C273(0.54); C145(0.81); C151(0.81)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C273(0.34); C145(0.68); C151(0.68)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C145(0.67); C151(0.67); C273(0.72)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C145(0.60); C151(0.60); C273(0.88)  LDD0683  [5]
 LDCM0248  AKOS034007472 HCT 116 C145(1.16); C151(1.24)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C145(1.14); C151(1.16)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C145(0.81); C151(0.86)  LDD0592  [5]
 LDCM0020  ARS-1620 HCC44 C349(1.05)  LDD0078  [5]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [9]
 LDCM0367  CL1 HCT 116 C273(1.26)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C273(0.85)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C273(0.80); C145(0.98); C146(0.98)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C145(0.93); C151(1.00)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C145(1.02); C151(1.15)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C145(1.15); C151(1.28)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C145(1.12); C151(1.20)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C273(0.54); C145(0.72); C151(0.72); C146(1.03)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C273(0.38); C145(0.55); C151(0.55); C146(1.13)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C273(0.38); C145(0.54); C151(0.54); C146(0.91)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C273(0.34); C145(0.47); C151(0.47); C146(0.90)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C273(0.51); C145(0.68); C151(0.68); C146(0.98)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C273(0.56)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C273(0.46); C145(0.74); C151(0.74); C146(1.06)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C273(0.57); C145(0.71); C151(0.71); C146(1.08)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C273(1.06)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C273(0.76)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C273(0.88)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C273(0.83)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C273(0.83)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C273(0.82); C146(1.14); C145(1.17); C151(1.18)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C273(1.01); C151(1.04); C145(1.07); C146(1.19)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C273(0.85); C151(1.01); C145(1.09); C146(1.49)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C273(0.64)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C151(1.20); C145(1.23); C146(1.25); C273(1.35)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C151(0.62); C273(0.67); C145(0.70); C146(0.95)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C146(0.90); C145(0.98); C273(0.98); C151(1.03)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C273(0.67); C151(0.77); C145(0.79); C146(0.85)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C273(0.62); C151(0.68); C145(0.74); C146(0.90)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C146(0.63); C273(0.74); C145(0.92); C151(1.21)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C273(0.72); C146(0.74); C145(0.77); C151(0.80)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C151(0.80); C145(0.82); C146(0.83); C273(0.99)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C151(0.47); C273(0.55); C145(0.61); C146(0.75)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C273(1.02)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C273(1.03)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C273(0.89)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C273(1.22)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C145(0.90); C146(0.90); C273(1.88)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C273(0.55); C145(1.00); C146(1.00)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C273(0.39); C145(0.99); C146(0.99)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C273(1.47)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C273(0.36); C145(1.04); C146(1.04)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C273(0.30); C145(1.02); C146(1.02)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C273(0.27); C145(1.27); C146(1.27)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C273(0.37); C145(0.86); C146(0.86)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C145(1.34); C146(1.34); C273(0.26)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C145(1.08); C146(1.08); C273(0.26)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C145(1.17); C146(1.17); C273(0.34)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C145(1.32); C146(1.32); C273(0.57)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C145(1.07); C146(1.07); C273(0.32)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C145(0.98); C146(0.98); C273(0.33)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C273(0.94)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C145(0.84); C146(0.84); C273(0.50)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C145(1.09); C146(1.09); C273(0.67)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C273(0.86)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C273(0.68)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C273(0.34)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C273(0.33)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C273(0.37)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C273(0.33)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C273(0.34)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C273(1.00)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C273(0.36)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C273(0.42)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C273(0.38)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C273(0.36)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C273(0.44)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C273(0.37)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C145(1.14); C146(1.17)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C145(1.10); C146(1.14)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C145(1.20); C146(1.10)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C145(1.05); C146(0.99)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C273(0.82)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C145(0.96); C146(0.85)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C145(0.95); C146(0.96)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C145(1.03); C146(0.98)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C145(0.96); C146(1.04)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C145(1.43); C146(1.01)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C145(1.09); C146(1.18)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C145(1.05); C146(0.95)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C145(0.92); C146(0.98)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C145(0.95); C146(0.99)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C145(1.17); C146(1.17)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C273(0.97)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C145(1.19); C146(1.03)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C145(1.22); C146(1.24); C273(0.85)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C145(1.17); C146(1.24); C273(0.76)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C145(1.15); C146(1.34); C273(0.57)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C145(1.16); C146(1.25); C273(0.55)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C145(1.01); C146(1.06); C273(0.86)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C145(1.16); C146(1.33); C273(0.33)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C145(0.96); C146(0.98); C273(0.42)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C145(1.07); C146(1.24); C273(0.65)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C145(1.12); C146(1.24); C273(0.94)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C273(0.66)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C145(0.93); C146(1.03); C273(0.91)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C145(1.19); C146(1.24); C273(0.65)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C145(1.31); C146(1.45); C273(0.86)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C145(1.03); C146(0.99); C273(0.52)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C145(1.11); C146(1.11); C273(0.56)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C145(1.06); C146(1.15); C273(0.90)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C145(1.01); C146(1.06); C273(0.70)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C145(0.98); C146(0.96); C273(0.76)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C145(1.23); C146(1.44); C273(0.49)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C273(0.64)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C145(1.21); C146(1.24); C273(0.79)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C145(1.08); C146(1.04); C273(0.59)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C145(1.32); C146(1.60); C273(0.47)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C145(1.03); C146(1.08); C273(0.46)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C145(1.18); C146(1.40); C273(0.42)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C145(1.03); C146(1.12); C273(0.67)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C145(0.99); C146(1.14); C273(0.76)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C145(0.98); C146(1.11); C273(0.57)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C145(1.04); C146(1.20); C273(0.43)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C145(1.14); C146(1.14); C273(0.53)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C273(0.64)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C145(1.00); C146(1.04); C273(0.93)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C145(1.42); C146(1.42); C273(0.96)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C145(0.85); C146(0.85); C273(0.82)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C145(0.70); C146(0.70); C273(0.98)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C145(0.69); C146(0.69); C273(0.83)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C145(1.05); C146(1.05); C273(0.75)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C145(1.27); C146(1.27); C273(0.86)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C145(1.06); C146(1.06); C273(0.95)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C145(1.49); C146(1.49); C273(0.77)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C145(1.42); C146(1.42); C273(0.88)  LDD0811  [5]
 LDCM0495  E2913 HEK-293T C349(0.89); C146(1.06)  LDD1698  [11]
 LDCM0468  Fragment33 HCT 116 C145(1.36); C146(1.62); C273(0.60)  LDD0785  [5]
 LDCM0427  Fragment51 HCT 116 C273(0.36)  LDD0744  [5]
 LDCM0022  KB02 HEK-293T C146(0.93)  LDD1492  [11]
 LDCM0023  KB03 HEK-293T C146(0.90)  LDD1497  [11]
 LDCM0024  KB05 COLO792 C71(4.01); C119(2.63); C273(1.81)  LDD3310  [12]
 LDCM0014  Panhematin K562 5.15  LDD0063  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Calcium/calmodulin-dependent protein kinase type II subunit alpha (CAMK2A) CAMK Ser/Thr protein kinase family Q9UQM7
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CUGBP Elav-like family member 5 (CELF5) CELF/BRUNOL family Q8N6W0
Proline-rich protein 13 (PRR13) . Q9NZ81
Uncharacterized protein C10orf55 (C10orf55) . Q5SWW7
Uncharacterized protein C1orf94 (C1orf94) . Q6P1W5

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
10 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840