Details of the Target

General Information of Target

Target ID LDTP00813
Target Name 5-hydroxymethyl-dUMP N-hydrolase (DNPH1)
Gene Name DNPH1
Gene ID 10591
Synonyms
C6orf108; RCL; 5-hydroxymethyl-dUMP N-hydrolase; EC 3.2.2.-; 2'-deoxynucleoside 5'-phosphate N-hydrolase 1; c-Myc-responsive protein RCL
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAAAMVPGRSESWERGEPGRPALYFCGSIRGGREDRTLYERIVSRLRRFGTVLTEHVAAA
ELGARGEEAAGGDRLIHEQDLEWLQQADVVVAEVTQPSLGVGYELGRAVAFNKRILCLFR
PQSGRVLSAMIRGAADGSRFQVWDYEEGEVEALLDRYFEADPPGQVAASPDPTT
Target Bioclass
Enzyme
Family
2'-deoxynucleoside 5'-phosphate N-hydrolase 1 family
Subcellular location
Cytoplasm
Function
Part of a nucleotide salvage pathway that eliminates epigenetically modified 5-hydroxymethyl-dCMP (hmdCMP) in a two-step process entailing deamination to cytotoxic 5-hydroxymethyl-dUMP (hmdUMP), followed by its hydrolysis into 5-hydroxymethyluracil (hmU) and 2-deoxy-D-ribose 5-phosphate (deoxyribosephosphate). Catalyzes the second step in that pathway, the hydrolysis of the N-glycosidic bond in hmdUMP, degrading this cytotoxic nucleotide to avoid its genomic integration.
Uniprot ID
O43598
Ensemble ID
ENST00000230431.11
HGNC ID
HGNC:21218
ChEMBL ID
CHEMBL3351218

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL33 SNV: p.R65S .
MFE319 SNV: p.L153R DBIA    Probe Info 
NCIH196 SNV: p.D88E .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C-Sul
 Probe Info  		27.55  LDD0066  [1]
DBIA
 Probe Info  		C26(2.15)  LDD3310  [2]
BTD
 Probe Info  		C26(0.26)  LDD2096  [3]
Acrolein
 Probe Info  		C117(0.00); H56(0.00)  LDD0221  [4]
5E-2FA
 Probe Info  		N.A.  LDD2235  [5]
m-APA
 Probe Info  		N.A.  LDD2231  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		C26(0.00); C117(0.00)  LDD0038  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [7]
Lodoacetamide azide
 Probe Info  		C26(0.00); C117(0.00)  LDD0037  [6]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [8]
Compound 10
 Probe Info  		N.A.  LDD2216  [9]
IPM
 Probe Info  		C26(0.00); C117(0.00)  LDD0147  [8]
NAIA_5
 Probe Info  		C26(0.00); C117(0.00)  LDD2223  [10]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C229
 Probe Info  		9.32  LDD1902  [11]
C278
 Probe Info  		48.17  LDD1948  [11]
C347
 Probe Info  		5.74  LDD2008  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C117(0.90); C26(1.04)  LDD1507  [12]
 LDCM0215  AC10 HEK-293T C117(0.88); C26(0.90)  LDD1508  [12]
 LDCM0226  AC11 HEK-293T C117(0.78); C26(0.95)  LDD1509  [12]
 LDCM0237  AC12 HEK-293T C117(0.78); C26(1.02)  LDD1510  [12]
 LDCM0259  AC14 HEK-293T C117(0.85); C26(1.08)  LDD1512  [12]
 LDCM0270  AC15 HEK-293T C117(0.84); C26(0.98)  LDD1513  [12]
 LDCM0276  AC17 HEK-293T C117(0.81); C26(0.95)  LDD1515  [12]
 LDCM0277  AC18 HEK-293T C117(0.84); C26(1.03)  LDD1516  [12]
 LDCM0278  AC19 HEK-293T C117(0.71); C26(0.83)  LDD1517  [12]
 LDCM0279  AC2 HEK-293T C117(0.94); C26(0.97)  LDD1518  [12]
 LDCM0280  AC20 HEK-293T C117(0.86); C26(0.93)  LDD1519  [12]
 LDCM0281  AC21 HEK-293T C117(0.94); C26(1.12)  LDD1520  [12]
 LDCM0282  AC22 HEK-293T C117(0.89); C26(0.95)  LDD1521  [12]
 LDCM0283  AC23 HEK-293T C117(0.85); C26(0.94)  LDD1522  [12]
 LDCM0284  AC24 HEK-293T C117(0.94); C26(1.02)  LDD1523  [12]
 LDCM0285  AC25 HEK-293T C117(0.86); C26(1.10)  LDD1524  [12]
 LDCM0286  AC26 HEK-293T C117(0.90); C26(1.00)  LDD1525  [12]
 LDCM0287  AC27 HEK-293T C117(0.82); C26(0.95)  LDD1526  [12]
 LDCM0288  AC28 HEK-293T C117(0.90); C26(1.02)  LDD1527  [12]
 LDCM0289  AC29 HEK-293T C117(0.88); C26(1.08)  LDD1528  [12]
 LDCM0290  AC3 HEK-293T C117(0.96); C26(0.97)  LDD1529  [12]
 LDCM0291  AC30 HEK-293T C117(0.92); C26(0.96)  LDD1530  [12]
 LDCM0292  AC31 HEK-293T C117(0.85); C26(1.04)  LDD1531  [12]
 LDCM0293  AC32 HEK-293T C117(0.96); C26(1.06)  LDD1532  [12]
 LDCM0294  AC33 HEK-293T C117(0.84); C26(0.96)  LDD1533  [12]
 LDCM0295  AC34 HEK-293T C117(0.88); C26(0.86)  LDD1534  [12]
 LDCM0296  AC35 HEK-293T C117(0.82); C26(0.94)  LDD1535  [12]
 LDCM0297  AC36 HEK-293T C117(0.92); C26(0.88)  LDD1536  [12]
 LDCM0298  AC37 HEK-293T C117(1.07); C26(1.17)  LDD1537  [12]
 LDCM0299  AC38 HEK-293T C117(0.95); C26(1.00)  LDD1538  [12]
 LDCM0300  AC39 HEK-293T C117(0.83); C26(0.95)  LDD1539  [12]
 LDCM0301  AC4 HEK-293T C117(0.93); C26(1.04)  LDD1540  [12]
 LDCM0302  AC40 HEK-293T C117(0.91); C26(1.06)  LDD1541  [12]
 LDCM0303  AC41 HEK-293T C117(0.82); C26(0.91)  LDD1542  [12]
 LDCM0304  AC42 HEK-293T C117(0.87); C26(0.87)  LDD1543  [12]
 LDCM0305  AC43 HEK-293T C117(0.77); C26(0.88)  LDD1544  [12]
 LDCM0306  AC44 HEK-293T C117(0.84); C26(0.99)  LDD1545  [12]
 LDCM0307  AC45 HEK-293T C117(0.99); C26(1.11)  LDD1546  [12]
 LDCM0308  AC46 HEK-293T C117(0.89); C26(1.11)  LDD1547  [12]
 LDCM0309  AC47 HEK-293T C117(0.86); C26(1.02)  LDD1548  [12]
 LDCM0310  AC48 HEK-293T C117(0.93); C26(1.08)  LDD1549  [12]
 LDCM0311  AC49 HEK-293T C117(0.89); C26(1.03)  LDD1550  [12]
 LDCM0312  AC5 HEK-293T C117(1.14); C26(1.04)  LDD1551  [12]
 LDCM0313  AC50 HEK-293T C117(0.95); C26(0.97)  LDD1552  [12]
 LDCM0314  AC51 HEK-293T C117(0.90); C26(0.94)  LDD1553  [12]
 LDCM0315  AC52 HEK-293T C117(0.85); C26(1.00)  LDD1554  [12]
 LDCM0316  AC53 HEK-293T C117(0.95); C26(1.15)  LDD1555  [12]
 LDCM0317  AC54 HEK-293T C117(0.89); C26(1.09)  LDD1556  [12]
 LDCM0318  AC55 HEK-293T C117(0.89); C26(0.86)  LDD1557  [12]
 LDCM0319  AC56 HEK-293T C117(0.90); C26(1.01)  LDD1558  [12]
 LDCM0320  AC57 HEK-293T C117(0.72); C26(0.99)  LDD1559  [12]
 LDCM0321  AC58 HEK-293T C117(0.88); C26(0.87)  LDD1560  [12]
 LDCM0322  AC59 HEK-293T C117(0.93); C26(0.92)  LDD1561  [12]
 LDCM0323  AC6 HEK-293T C117(0.96); C26(1.09)  LDD1562  [12]
 LDCM0324  AC60 HEK-293T C117(0.86); C26(0.94)  LDD1563  [12]
 LDCM0325  AC61 HEK-293T C117(1.00); C26(1.13)  LDD1564  [12]
 LDCM0326  AC62 HEK-293T C117(0.97); C26(0.96)  LDD1565  [12]
 LDCM0327  AC63 HEK-293T C117(0.88); C26(0.87)  LDD1566  [12]
 LDCM0328  AC64 HEK-293T C117(1.01); C26(0.99)  LDD1567  [12]
 LDCM0334  AC7 HEK-293T C117(0.95); C26(0.96)  LDD1568  [12]
 LDCM0345  AC8 HEK-293T C117(0.89); C26(0.96)  LDD1569  [12]
 LDCM0248  AKOS034007472 HEK-293T C117(0.98); C26(1.11)  LDD1511  [12]
 LDCM0356  AKOS034007680 HEK-293T C117(0.84); C26(1.04)  LDD1570  [12]
 LDCM0275  AKOS034007705 HEK-293T C117(0.89); C26(1.06)  LDD1514  [12]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [4]
 LDCM0367  CL1 HEK-293T C117(0.75); C26(0.96)  LDD1571  [12]
 LDCM0368  CL10 HEK-293T C117(0.55); C26(1.06)  LDD1572  [12]
 LDCM0369  CL100 HEK-293T C117(0.97)  LDD1573  [12]
 LDCM0370  CL101 HEK-293T C117(0.86); C26(1.02)  LDD1574  [12]
 LDCM0371  CL102 HEK-293T C117(0.92); C26(0.94)  LDD1575  [12]
 LDCM0372  CL103 HEK-293T C117(0.83); C26(0.90)  LDD1576  [12]
 LDCM0373  CL104 HEK-293T C117(0.91)  LDD1577  [12]
 LDCM0374  CL105 HEK-293T C117(0.88); C26(0.89)  LDD1578  [12]
 LDCM0375  CL106 HEK-293T C117(0.92); C26(0.94)  LDD1579  [12]
 LDCM0376  CL107 HEK-293T C117(0.90); C26(0.88)  LDD1580  [12]
 LDCM0377  CL108 HEK-293T C117(0.91)  LDD1581  [12]
 LDCM0378  CL109 HEK-293T C117(0.96); C26(1.00)  LDD1582  [12]
 LDCM0379  CL11 HEK-293T C117(0.57); C26(0.93)  LDD1583  [12]
 LDCM0380  CL110 HEK-293T C117(0.89); C26(0.93)  LDD1584  [12]
 LDCM0381  CL111 HEK-293T C117(0.82); C26(0.88)  LDD1585  [12]
 LDCM0382  CL112 HEK-293T C117(0.90)  LDD1586  [12]
 LDCM0383  CL113 HEK-293T C117(0.92); C26(0.95)  LDD1587  [12]
 LDCM0384  CL114 HEK-293T C117(0.93); C26(0.91)  LDD1588  [12]
 LDCM0385  CL115 HEK-293T C117(0.90); C26(0.91)  LDD1589  [12]
 LDCM0386  CL116 HEK-293T C117(0.92)  LDD1590  [12]
 LDCM0387  CL117 HEK-293T C117(0.95); C26(0.95)  LDD1591  [12]
 LDCM0388  CL118 HEK-293T C117(0.90); C26(0.94)  LDD1592  [12]
 LDCM0389  CL119 HEK-293T C117(0.88); C26(0.88)  LDD1593  [12]
 LDCM0390  CL12 HEK-293T C117(0.63); C26(1.02)  LDD1594  [12]
 LDCM0391  CL120 HEK-293T C117(0.86)  LDD1595  [12]
 LDCM0392  CL121 HEK-293T C117(0.90); C26(1.01)  LDD1596  [12]
 LDCM0393  CL122 HEK-293T C117(0.96); C26(0.97)  LDD1597  [12]
 LDCM0394  CL123 HEK-293T C117(0.81); C26(0.94)  LDD1598  [12]
 LDCM0395  CL124 HEK-293T C117(0.92)  LDD1599  [12]
 LDCM0396  CL125 HEK-293T C117(1.06); C26(1.04)  LDD1600  [12]
 LDCM0397  CL126 HEK-293T C117(0.90); C26(0.89)  LDD1601  [12]
 LDCM0398  CL127 HEK-293T C117(1.03); C26(0.87)  LDD1602  [12]
 LDCM0399  CL128 HEK-293T C117(0.99)  LDD1603  [12]
 LDCM0400  CL13 HEK-293T C117(0.78); C26(0.96)  LDD1604  [12]
 LDCM0401  CL14 HEK-293T C117(0.81); C26(0.93)  LDD1605  [12]
 LDCM0402  CL15 HEK-293T C117(0.70); C26(0.85)  LDD1606  [12]
 LDCM0403  CL16 HEK-293T C117(0.74)  LDD1607  [12]
 LDCM0404  CL17 HEK-293T C117(0.66); C26(1.01)  LDD1608  [12]
 LDCM0405  CL18 HEK-293T C117(0.60); C26(0.92)  LDD1609  [12]
 LDCM0406  CL19 HEK-293T C117(0.66); C26(1.16)  LDD1610  [12]
 LDCM0407  CL2 HEK-293T C117(0.81); C26(0.95)  LDD1611  [12]
 LDCM0408  CL20 HEK-293T C117(0.68); C26(1.16)  LDD1612  [12]
 LDCM0409  CL21 HEK-293T C117(0.54); C26(1.62)  LDD1613  [12]
 LDCM0410  CL22 HEK-293T C117(0.70); C26(1.18)  LDD1614  [12]
 LDCM0411  CL23 HEK-293T C117(0.57); C26(0.91)  LDD1615  [12]
 LDCM0412  CL24 HEK-293T C117(0.70); C26(1.07)  LDD1616  [12]
 LDCM0413  CL25 HEK-293T C117(0.96); C26(1.00)  LDD1617  [12]
 LDCM0414  CL26 HEK-293T C117(0.90); C26(1.03)  LDD1618  [12]
 LDCM0415  CL27 HEK-293T C117(0.82); C26(0.94)  LDD1619  [12]
 LDCM0416  CL28 HEK-293T C117(0.81)  LDD1620  [12]
 LDCM0417  CL29 HEK-293T C117(0.75); C26(1.04)  LDD1621  [12]
 LDCM0418  CL3 HEK-293T C117(0.71); C26(0.93)  LDD1622  [12]
 LDCM0419  CL30 HEK-293T C117(0.75); C26(0.98)  LDD1623  [12]
 LDCM0420  CL31 HEK-293T C117(0.62); C26(1.11)  LDD1624  [12]
 LDCM0421  CL32 HEK-293T C117(0.67); C26(1.13)  LDD1625  [12]
 LDCM0422  CL33 HEK-293T C117(0.60); C26(1.47)  LDD1626  [12]
 LDCM0423  CL34 HEK-293T C117(0.64); C26(1.22)  LDD1627  [12]
 LDCM0424  CL35 HEK-293T C117(0.60); C26(0.92)  LDD1628  [12]
 LDCM0425  CL36 HEK-293T C117(0.69); C26(0.97)  LDD1629  [12]
 LDCM0426  CL37 HEK-293T C117(0.92); C26(1.00)  LDD1630  [12]
 LDCM0428  CL39 HEK-293T C117(0.85); C26(1.01)  LDD1632  [12]
 LDCM0429  CL4 HEK-293T C117(0.80)  LDD1633  [12]
 LDCM0430  CL40 HEK-293T C117(0.86)  LDD1634  [12]
 LDCM0431  CL41 HEK-293T C117(0.67); C26(1.02)  LDD1635  [12]
 LDCM0432  CL42 HEK-293T C117(0.81); C26(1.06)  LDD1636  [12]
 LDCM0433  CL43 HEK-293T C117(0.69); C26(1.16)  LDD1637  [12]
 LDCM0434  CL44 HEK-293T C117(0.67); C26(1.05)  LDD1638  [12]
 LDCM0435  CL45 HEK-293T C117(0.71); C26(1.36)  LDD1639  [12]
 LDCM0436  CL46 HEK-293T C117(0.68); C26(1.13)  LDD1640  [12]
 LDCM0437  CL47 HEK-293T C117(0.60); C26(0.98)  LDD1641  [12]
 LDCM0438  CL48 HEK-293T C117(0.69); C26(0.97)  LDD1642  [12]
 LDCM0439  CL49 HEK-293T C117(1.03); C26(0.94)  LDD1643  [12]
 LDCM0440  CL5 HEK-293T C117(0.80); C26(1.21)  LDD1644  [12]
 LDCM0441  CL50 HEK-293T C117(0.87); C26(0.94)  LDD1645  [12]
 LDCM0443  CL52 HEK-293T C117(0.86)  LDD1646  [12]
 LDCM0444  CL53 HEK-293T C117(0.71); C26(0.98)  LDD1647  [12]
 LDCM0445  CL54 HEK-293T C117(0.70); C26(0.90)  LDD1648  [12]
 LDCM0446  CL55 HEK-293T C117(0.67); C26(1.06)  LDD1649  [12]
 LDCM0447  CL56 HEK-293T C117(0.66); C26(1.14)  LDD1650  [12]
 LDCM0448  CL57 HEK-293T C117(0.65); C26(1.54)  LDD1651  [12]
 LDCM0449  CL58 HEK-293T C117(0.66); C26(1.17)  LDD1652  [12]
 LDCM0450  CL59 HEK-293T C117(0.57); C26(0.87)  LDD1653  [12]
 LDCM0451  CL6 HEK-293T C117(0.58); C26(0.82)  LDD1654  [12]
 LDCM0452  CL60 HEK-293T C117(0.72); C26(1.03)  LDD1655  [12]
 LDCM0453  CL61 HEK-293T C117(1.08); C26(1.00)  LDD1656  [12]
 LDCM0454  CL62 HEK-293T C117(0.90); C26(0.97)  LDD1657  [12]
 LDCM0455  CL63 HEK-293T C117(0.86); C26(0.86)  LDD1658  [12]
 LDCM0456  CL64 HEK-293T C117(0.75)  LDD1659  [12]
 LDCM0457  CL65 HEK-293T C117(0.72); C26(0.96)  LDD1660  [12]
 LDCM0458  CL66 HEK-293T C117(0.76); C26(0.86)  LDD1661  [12]
 LDCM0459  CL67 HEK-293T C117(0.67); C26(1.08)  LDD1662  [12]
 LDCM0460  CL68 HEK-293T C117(0.65); C26(1.03)  LDD1663  [12]
 LDCM0461  CL69 HEK-293T C117(0.74); C26(1.35)  LDD1664  [12]
 LDCM0462  CL7 HEK-293T C117(0.70); C26(1.05)  LDD1665  [12]
 LDCM0463  CL70 HEK-293T C117(0.67); C26(1.08)  LDD1666  [12]
 LDCM0464  CL71 HEK-293T C117(0.62); C26(0.89)  LDD1667  [12]
 LDCM0465  CL72 HEK-293T C117(0.69); C26(0.99)  LDD1668  [12]
 LDCM0466  CL73 HEK-293T C117(1.08); C26(1.06)  LDD1669  [12]
 LDCM0467  CL74 HEK-293T C117(1.03); C26(1.03)  LDD1670  [12]
 LDCM0469  CL76 HEK-293T C117(0.88)  LDD1672  [12]
 LDCM0470  CL77 HEK-293T C117(0.73); C26(0.94)  LDD1673  [12]
 LDCM0471  CL78 HEK-293T C117(0.81); C26(0.99)  LDD1674  [12]
 LDCM0472  CL79 HEK-293T C117(0.82); C26(1.09)  LDD1675  [12]
 LDCM0473  CL8 HEK-293T C117(0.46); C26(0.80)  LDD1676  [12]
 LDCM0474  CL80 HEK-293T C117(0.80); C26(1.21)  LDD1677  [12]
 LDCM0475  CL81 HEK-293T C117(0.81); C26(1.61)  LDD1678  [12]
 LDCM0476  CL82 HEK-293T C117(0.75); C26(1.17)  LDD1679  [12]
 LDCM0477  CL83 HEK-293T C117(0.66); C26(0.95)  LDD1680  [12]
 LDCM0478  CL84 HEK-293T C117(0.77); C26(1.00)  LDD1681  [12]
 LDCM0479  CL85 HEK-293T C117(1.07); C26(0.96)  LDD1682  [12]
 LDCM0480  CL86 HEK-293T C117(0.86); C26(0.95)  LDD1683  [12]
 LDCM0481  CL87 HEK-293T C117(0.99); C26(0.89)  LDD1684  [12]
 LDCM0482  CL88 HEK-293T C117(0.88)  LDD1685  [12]
 LDCM0483  CL89 HEK-293T C117(0.78); C26(1.19)  LDD1686  [12]
 LDCM0484  CL9 HEK-293T C117(0.73); C26(1.68)  LDD1687  [12]
 LDCM0485  CL90 HEK-293T C117(0.68); C26(0.93)  LDD1688  [12]
 LDCM0486  CL91 HEK-293T C117(0.82); C26(1.10)  LDD1689  [12]
 LDCM0487  CL92 HEK-293T C117(0.66); C26(1.04)  LDD1690  [12]
 LDCM0488  CL93 HEK-293T C117(0.81); C26(1.43)  LDD1691  [12]
 LDCM0489  CL94 HEK-293T C117(0.68); C26(1.18)  LDD1692  [12]
 LDCM0490  CL95 HEK-293T C117(0.58); C26(0.87)  LDD1693  [12]
 LDCM0491  CL96 HEK-293T C117(0.70); C26(0.97)  LDD1694  [12]
 LDCM0492  CL97 HEK-293T C117(0.95); C26(0.95)  LDD1695  [12]
 LDCM0493  CL98 HEK-293T C117(0.90); C26(0.90)  LDD1696  [12]
 LDCM0494  CL99 HEK-293T C117(0.98); C26(0.98)  LDD1697  [12]
 LDCM0495  E2913 HEK-293T C117(0.74); C26(0.61)  LDD1698  [12]
 LDCM0625  F8 Ramos C117(0.41); C26(0.73)  LDD2187  [13]
 LDCM0572  Fragment10 Ramos C117(0.50); C26(0.25)  LDD2189  [13]
 LDCM0573  Fragment11 Ramos C117(0.10)  LDD2190  [13]
 LDCM0574  Fragment12 Ramos C117(0.49); C26(0.32)  LDD2191  [13]
 LDCM0575  Fragment13 Ramos C117(0.79); C26(1.05)  LDD2192  [13]
 LDCM0576  Fragment14 Ramos C117(0.90); C26(1.92)  LDD2193  [13]
 LDCM0579  Fragment20 Ramos C117(0.38); C26(0.21)  LDD2194  [13]
 LDCM0580  Fragment21 Ramos C117(0.74); C26(0.88)  LDD2195  [13]
 LDCM0582  Fragment23 Ramos C117(1.27); C26(1.27)  LDD2196  [13]
 LDCM0578  Fragment27 Ramos C117(0.86)  LDD2197  [13]
 LDCM0586  Fragment28 Ramos C117(0.78); C26(0.95)  LDD2198  [13]
 LDCM0588  Fragment30 Ramos C117(0.68); C26(0.59)  LDD2199  [13]
 LDCM0589  Fragment31 Ramos C117(0.86); C26(1.34)  LDD2200  [13]
 LDCM0590  Fragment32 Ramos C117(0.43); C26(0.29)  LDD2201  [13]
 LDCM0468  Fragment33 HEK-293T C117(0.92); C26(1.02)  LDD1671  [12]
 LDCM0596  Fragment38 Ramos C117(0.78)  LDD2203  [13]
 LDCM0566  Fragment4 Ramos C117(0.51); C26(0.57)  LDD2184  [13]
 LDCM0427  Fragment51 HEK-293T C117(0.86); C26(0.99)  LDD1631  [12]
 LDCM0610  Fragment52 Ramos C117(0.78)  LDD2204  [13]
 LDCM0614  Fragment56 Ramos C117(0.96); C26(2.37)  LDD2205  [13]
 LDCM0569  Fragment7 Ramos C117(0.28); C26(0.30)  LDD2186  [13]
 LDCM0571  Fragment9 Ramos C117(0.44); C26(0.18)  LDD2188  [13]
 LDCM0107  IAA HeLa C117(0.00); H56(0.00)  LDD0221  [4]
 LDCM0022  KB02 HEK-293T C26(1.04); C117(1.15)  LDD1492  [12]
 LDCM0023  KB03 Jurkat C26(8.07)  LDD0315  [7]
 LDCM0024  KB05 COLO792 C26(2.15)  LDD3310  [2]
 LDCM0109  NEM HeLa N.A.  LDD0223  [4]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C26(0.26)  LDD2096  [3]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C26(0.40)  LDD2145  [3]
 LDCM0131  RA190 MM1.R C26(1.19)  LDD0304  [14]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
5-hydroxymethyl-dUMP N-hydrolase (DNPH1) 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 family O43598
Histone acetyltransferase KAT5 (KAT5) MYST (SAS/MOZ) family Q92993
Protein kinase C alpha type (PRKCA) AGC Ser/Thr protein kinase family P17252
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein gamma (YWHAG) 14-3-3 family P61981
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA damage-inducible transcript 4-like protein (DDIT4L) DDIT4 family Q96D03
Telomeric repeat-binding factor 1 (TERF1) . P54274

References

1 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
13 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
14 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.