Details of the Target

General Information of Target

Target ID LDTP13163
Target Name Nuclear RNA export factor 1 (NXF1)
Gene Name NXF1
Gene ID 10482
Synonyms
TAP; Nuclear RNA export factor 1; Tip-associated protein; Tip-associating protein; mRNA export factor TAP
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAPKQDPKPKFQEGERVLCFHGPLLYEAKCVKVAIKDKQVKYFIHYSGWNKKSAVRPRRS
EKSLKTHEDIVALFPVPEGAPSVHHPLLTSSWDEWVPESRVLKYVDTNLQKQRELQKANQ
EQYAEGKMRGAAPGKKTSGLQQKNVEVKTKKNKQKTPGNGDGGSTSETPQPPRKKRARVD
PTVENEETFMNRVEVKVKIPEELKPWLVDDWDLITRQKQLFYLPAKKNVDSILEDYANYK
KSRGNTDNKEYAVNEVVAGIKEYFNVMLGTQLLYKFERPQYAEILADHPDAPMSQVYGAP
HLLRLFVRIGAMLAYTPLDEKSLALLLNYLHDFLKYLAKNSATLFSASDYEVAPPEYHRK
AV
Target Bioclass
Transporter and channel
Family
NXF family
Subcellular location
Nucleus
Function
Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex. ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export. Also involved in nuclear export of m6A-containing mRNAs: interaction between SRSF3 and YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export.
Uniprot ID
Q9UBU9
Ensemble ID
ENST00000294172.7
HGNC ID
HGNC:8071

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT116 Deletion: p.T368RfsTer16 DBIA    Probe Info 
HT115 SNV: p.A174T DBIA    Probe Info 
HUH28 SNV: p.E4K DBIA    Probe Info 
JURKAT SNV: p.A171V Compound 10    Probe Info 
KYSE410 SNV: p.V163L DBIA    Probe Info 
MOLT4 SNV: p.A549T IA-alkyne    Probe Info 
NALM6 SNV: p.R429Ter DBIA    Probe Info 
NUGC3 SNV: p.R38C DBIA    Probe Info 
OVK18 SNV: p.R219Ter DBIA    Probe Info 
P31FUJ SNV: p.E210D DBIA    Probe Info 
PEO1 SNV: p.P265H DBIA    Probe Info 
RD SNV: p.L469F DBIA    Probe Info 
SUPT1 Deletion: p.L257Ter DBIA    Probe Info 
SW620 SNV: p.D13N DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 21 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K178(1.12); K609(7.03)  LDD0277  [1]
BTD
 Probe Info  		C252(1.05)  LDD2091  [2]
DBIA
 Probe Info  		C252(0.93)  LDD0078  [3]
ATP probe
 Probe Info  		N.A.  LDD0199  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		C143(0.00); C328(0.00); C252(0.00); C528(0.00)  LDD0038  [5]
IA-alkyne
 Probe Info  		C373(0.00); C143(0.00)  LDD0032  [6]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [7]
Lodoacetamide azide
 Probe Info  		C143(0.00); C373(0.00); C252(0.00); C528(0.00)  LDD0037  [5]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [8]
NAIA_4
 Probe Info  		C143(0.00); C328(0.00)  LDD2226  [9]
TFBX
 Probe Info  		C143(0.00); C252(0.00)  LDD0027  [8]
Compound 10
 Probe Info  		N.A.  LDD2216  [10]
Compound 11
 Probe Info  		N.A.  LDD2213  [10]
IPM
 Probe Info  		N.A.  LDD0005  [11]
NHS
 Probe Info  		N.A.  LDD0010  [11]
SF
 Probe Info  		N.A.  LDD0028  [12]
Acrolein
 Probe Info  		C328(0.00); H11(0.00); C373(0.00); C528(0.00)  LDD0217  [13]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [13]
W1
 Probe Info  		N.A.  LDD0236  [14]
AOyne
 Probe Info  		5.60  LDD0443  [15]
NAIA_5
 Probe Info  		C143(0.00); C328(0.00); C373(0.00)  LDD2223  [9]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C196
 Probe Info  		11.96  LDD1872  [16]
FFF probe2
 Probe Info  		12.96  LDD0463  [17]
STS-2
 Probe Info  		1.00  LDD0139  [18]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C252(1.01)  LDD2117  [2]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C252(1.41)  LDD2152  [2]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C252(0.91)  LDD2131  [2]
 LDCM0214  AC1 HCT 116 C252(1.08); C328(0.83)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C252(1.18); C328(1.02)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C143(0.37); C252(0.91); C328(0.50)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C143(0.51); C252(1.03); C328(0.58)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C143(0.42); C252(0.93); C328(0.51)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C143(0.37); C252(1.15); C328(0.41)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C143(0.35); C252(1.07); C328(0.39)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C143(0.45); C252(1.03); C328(0.45)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C143(0.40); C252(0.98); C328(0.42)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C143(0.47); C252(1.01); C328(0.41)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C143(0.51); C252(0.88); C328(0.59)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C143(0.43); C252(0.84); C328(0.66)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C252(1.13); C328(0.89)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C143(0.35); C252(0.89); C328(0.55)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C143(0.37); C252(0.81); C328(0.63)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C143(0.39); C252(1.13); C328(0.42)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C143(1.20); C252(1.01); C328(0.89)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C143(0.82); C252(1.01); C328(0.60)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C143(0.70); C252(1.25); C328(0.66)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C143(0.73); C252(1.37); C328(0.58)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C143(0.93); C252(0.96); C328(0.59)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C143(0.89); C252(0.90); C328(0.75)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C143(0.77); C252(1.04); C328(0.77)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C252(1.09); C328(0.96)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C143(0.58); C252(0.97); C328(0.57)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C143(1.22); C252(0.94); C328(0.70)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C143(0.92); C252(1.18); C328(0.58)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C143(1.12); C252(0.96); C328(0.87)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C143(1.00); C252(0.78); C328(0.69)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C143(0.96); C252(1.14); C328(0.68)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C143(0.78); C252(1.23); C328(0.58)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C143(0.92); C252(0.99); C328(0.62)  LDD0562  [3]
 LDCM0246  AC128 HCT 116 C252(0.49); C328(0.85)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C252(0.59); C328(1.52)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C252(0.59); C328(1.04)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C252(0.50); C328(1.37)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C252(0.62); C328(1.07)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C252(0.49); C328(1.03)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C252(0.62); C328(1.02)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C252(0.45); C328(1.25)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C252(0.50); C328(1.14)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C252(0.45); C328(1.32)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C252(0.46); C328(1.13)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C252(0.67); C328(1.08)  LDD0575  [3]
 LDCM0259  AC14 HCT 116 C252(1.13); C328(1.12)  LDD0576  [3]
 LDCM0260  AC140 HCT 116 C252(0.68); C328(1.11)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C252(0.58); C328(1.16)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C252(0.63); C328(1.50)  LDD0579  [3]
 LDCM0263  AC143 HCT 116 C143(0.66); C328(1.11); C252(1.17)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C143(0.44); C328(0.61); C252(1.42)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C143(0.56); C328(0.59); C252(1.38)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C143(0.55); C328(0.60); C252(1.49)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C143(0.52); C328(0.65); C252(1.53)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C143(0.41); C328(0.60); C252(1.69)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C143(0.52); C328(0.60); C252(1.56)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C328(0.93); C252(1.08)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C143(0.68); C328(0.69); C252(1.19)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C143(0.47); C328(0.85); C252(1.13)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C143(0.42); C328(0.50); C252(1.81)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C328(0.48); C143(0.51); C252(1.98)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C143(0.45); C252(1.57); C328(0.76)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C143(0.44); C252(1.39); C328(0.74)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C143(0.58); C252(1.29); C328(0.97)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C143(0.62); C252(1.18); C328(0.61)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C252(0.96)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C252(1.11)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C252(0.96)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C328(1.06); C252(1.17)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C252(1.14)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C252(1.06)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C252(1.06)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C252(1.03)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C252(0.99)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C252(0.88)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C252(1.11)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C252(1.02)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C252(1.07)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C252(1.17)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C328(0.98); C252(1.12)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C252(1.09)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C252(0.99)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C252(1.28)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C252(0.99)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C252(0.92)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C252(0.96)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C252(0.89)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C252(0.88)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C252(1.02)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C252(1.18)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C328(0.85); C252(1.18)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C252(1.20)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C252(0.97)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C252(1.07)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C252(1.15)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C252(0.96)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C252(1.07)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C252(1.17); C143(1.50)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C252(1.11); C143(1.22)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C252(1.03); C143(1.12)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C143(1.05); C252(1.10)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C328(0.95); C252(1.26)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C252(0.95); C143(1.19)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C252(0.98); C143(1.17)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C252(0.99); C143(1.00)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C252(0.96); C143(0.98)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C252(0.99); C143(1.24)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C252(0.87); C143(1.12)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C252(0.96); C143(1.31)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C252(1.63)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C252(1.49)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C252(1.51)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C328(0.91); C252(1.33)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C252(1.65)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C252(1.60)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C252(1.64)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C252(1.61)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C252(1.75)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C252(1.75)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C252(1.59)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C252(1.74)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C328(0.77); C252(0.96); C143(0.99)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C328(0.62); C252(0.90); C143(1.07)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C328(0.98); C252(1.22)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C328(0.46); C143(0.91); C252(0.95)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C328(0.85); C252(0.92); C143(1.46)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C328(0.73); C252(1.00); C143(1.03)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C328(0.55); C252(1.07); C143(1.23)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C328(0.50); C252(0.99); C143(1.12)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C328(0.83); C252(0.97); C143(1.10)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C328(0.67); C252(0.89); C143(1.18)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C328(0.51); C252(0.99); C143(1.21)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C328(0.73); C252(0.93); C143(1.16)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C328(0.76); C252(1.04); C143(1.36)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C328(0.79); C252(1.16)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C328(0.75); C252(0.87); C143(1.01)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C328(0.53); C252(0.98); C143(1.04)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C328(0.44); C252(0.91); C143(1.33)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C252(1.56)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C252(1.21)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C252(1.19)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C252(1.14)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C252(1.07)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C252(1.21)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C252(1.36)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C252(1.25)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C252(1.32)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C252(1.23)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C252(1.23)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C252(1.16)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C252(1.19)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C252(1.18)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C252(1.23)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C328(0.30); C143(0.32); C252(1.22)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C143(0.53); C328(0.60); C252(0.91)  LDD0683  [3]
 LDCM0545  Acetamide MDA-MB-231 C252(0.84)  LDD2138  [2]
 LDCM0248  AKOS034007472 HCT 116 C252(1.15); C328(1.16)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C328(1.10); C252(1.23)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C328(0.78); C252(1.60)  LDD0592  [3]
 LDCM0020  ARS-1620 HCC44 C252(0.93)  LDD0078  [3]
 LDCM0498  BS-3668 MDA-MB-231 C252(1.05)  LDD2091  [2]
 LDCM0108  Chloroacetamide HeLa C328(0.00); C528(0.00); H11(0.00)  LDD0222  [13]
 LDCM0367  CL1 HCT 116 C252(1.01); C328(1.30)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C328(0.78); C252(1.66)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C328(0.83); C252(1.17)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C328(0.95); C252(1.09)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C252(0.97); C328(1.10)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C328(0.99); C252(1.27)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C252(1.12); C328(1.12)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C252(1.16)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C252(1.07)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C252(1.09)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C252(1.19)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C252(1.02)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C328(0.75); C252(1.54)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C252(1.11)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C252(1.13)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C252(0.90)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C252(1.10)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C252(0.97)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C252(0.94)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C252(1.03)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C252(1.28)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C252(1.11)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C252(1.17)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C328(0.83); C252(1.41)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C252(1.06)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C143(1.08); C252(1.11)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C143(1.09); C252(1.23)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C252(0.95); C143(1.13)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C143(1.12); C252(1.37)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C252(1.14)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C252(1.34)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C252(1.36)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C252(1.52)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C328(0.80); C252(1.25)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C328(1.00); C252(1.12)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C328(0.91); C252(1.18)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C252(0.58); C328(0.89)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C252(1.17); C328(1.24)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C328(0.89); C252(1.01)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C252(0.99); C328(1.35)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C328(1.04); C252(1.27)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C252(1.13); C328(1.29)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C328(0.82); C252(1.07)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C328(0.92); C252(1.02)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C252(1.04); C328(1.20)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C252(1.26); C328(1.27)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C252(1.05); C328(0.99)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C252(1.09); C328(0.87)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C252(1.03); C328(0.96)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C252(0.95); C328(1.09)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C252(1.08); C328(1.09)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C252(1.32); C328(0.96)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C252(0.93); C328(0.97)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C252(1.11)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C252(1.26)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C252(1.23)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C252(1.72)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C252(1.27)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C252(1.13)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C252(1.36)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C252(1.21)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C252(1.07); C328(0.87)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C252(1.24)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C252(1.41)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C252(2.03)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C252(1.48)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C252(1.24)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C252(1.40)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C252(1.07)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C252(1.00)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C252(0.91)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C252(0.98)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C252(1.18); C328(0.84)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C252(1.09)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C252(1.03)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C252(0.92)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C252(1.03)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C252(0.80)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C252(0.84)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C252(0.93)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C252(0.86)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C252(0.78)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C252(0.86)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C252(1.27); C328(0.81)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C252(0.91)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C252(0.98); C328(0.88)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C252(0.87); C328(1.30)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C252(1.17); C328(0.82)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C252(1.06); C328(1.49)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C252(0.89); C328(1.29)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C252(1.19); C328(1.10)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C252(1.03); C328(1.09)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C252(0.96); C328(1.52)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C252(0.86); C328(1.27)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C252(1.24); C328(0.76)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C252(1.09); C328(1.18)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C252(0.95); C328(1.28)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C252(1.01); C328(0.88)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C252(0.89); C328(1.27)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C252(0.90); C328(1.55)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C252(1.00); C328(0.81)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C252(1.14); C328(0.85)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C252(1.28); C328(0.73)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C252(1.08); C328(0.69)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C252(1.60); C328(0.62)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C252(1.11); C328(0.89)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C252(1.48); C328(0.79)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C252(1.83); C328(0.61)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C252(1.46); C328(0.63)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C252(2.02); C328(0.66)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C252(1.66); C328(0.79)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C252(1.08); C328(0.88)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C252(1.28); C328(0.79)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C252(1.47); C328(0.70)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C252(2.36); C328(0.69)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C252(1.32); C328(0.82)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C252(0.98); C328(1.13)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C252(1.28); C328(0.97)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C252(1.14); C328(0.85)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C252(0.99); C328(1.04)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C252(1.16); C328(0.75)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C252(1.17); C328(0.81)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C252(1.20); C328(0.79)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C252(1.14); C328(0.82)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C252(1.25); C328(0.87)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C252(1.09); C328(0.76)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C252(0.88); C373(1.04); C328(1.07); C528(0.93)  LDD1698  [19]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C252(1.13)  LDD1702  [2]
 LDCM0625  F8 Ramos C252(1.32); C143(0.95)  LDD2187  [20]
 LDCM0572  Fragment10 Ramos C252(0.90); C143(1.18)  LDD2189  [20]
 LDCM0573  Fragment11 Ramos C143(0.62)  LDD2190  [20]
 LDCM0574  Fragment12 Ramos C252(0.87); C143(1.76)  LDD2191  [20]
 LDCM0575  Fragment13 Ramos C252(0.81)  LDD2192  [20]
 LDCM0576  Fragment14 Ramos C252(0.97); C143(0.89)  LDD2193  [20]
 LDCM0579  Fragment20 Ramos C252(0.78); C143(1.15)  LDD2194  [20]
 LDCM0580  Fragment21 Ramos C252(0.97); C143(1.58)  LDD2195  [20]
 LDCM0582  Fragment23 Ramos C252(0.98); C143(1.61)  LDD2196  [20]
 LDCM0578  Fragment27 Ramos C252(0.92)  LDD2197  [20]
 LDCM0586  Fragment28 Ramos C252(0.86); C143(1.22)  LDD2198  [20]
 LDCM0588  Fragment30 Ramos C252(1.09); C143(2.03)  LDD2199  [20]
 LDCM0589  Fragment31 Ramos C252(0.98); C143(1.45)  LDD2200  [20]
 LDCM0590  Fragment32 Ramos C252(0.86); C143(1.42)  LDD2201  [20]
 LDCM0468  Fragment33 HCT 116 C252(1.03); C328(1.12)  LDD0785  [3]
 LDCM0596  Fragment38 Ramos C252(0.80)  LDD2203  [20]
 LDCM0566  Fragment4 Ramos C252(1.06); C143(0.76)  LDD2184  [20]
 LDCM0427  Fragment51 HCT 116 C252(2.26)  LDD0744  [3]
 LDCM0610  Fragment52 Ramos C252(1.12); C143(7.47)  LDD2204  [20]
 LDCM0614  Fragment56 Ramos C252(0.93); C143(1.76)  LDD2205  [20]
 LDCM0569  Fragment7 Ramos C252(1.35); C143(0.79)  LDD2186  [20]
 LDCM0571  Fragment9 Ramos C252(2.31); C143(1.28)  LDD2188  [20]
 LDCM0107  IAA HeLa C328(0.00); H11(0.00)  LDD0221  [13]
 LDCM0022  KB02 HCT 116 C252(1.19)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C252(0.98)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C252(2.95)  LDD0082  [3]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C252(1.26)  LDD2121  [2]
 LDCM0109  NEM HeLa N.A.  LDD0223  [13]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C252(0.91)  LDD2093  [2]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C252(1.24)  LDD2099  [2]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C252(0.85)  LDD2107  [2]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C252(0.96)  LDD2109  [2]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C252(1.13)  LDD2111  [2]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C252(0.68)  LDD2114  [2]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C252(0.67)  LDD2118  [2]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C252(1.70)  LDD2120  [2]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C252(1.11)  LDD2122  [2]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C252(0.96); C373(1.26)  LDD2123  [2]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C252(1.06)  LDD2125  [2]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C252(1.06)  LDD2126  [2]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C252(1.04)  LDD2127  [2]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C252(1.51)  LDD2129  [2]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C252(1.12)  LDD2135  [2]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C252(1.32)  LDD2136  [2]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C252(0.99)  LDD2137  [2]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C252(1.22)  LDD2140  [2]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C252(2.19)  LDD2144  [2]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C252(1.07)  LDD2146  [2]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C252(0.91)  LDD2148  [2]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C252(1.03)  LDD2150  [2]
 LDCM0131  RA190 MM1.R C252(1.12)  LDD0304  [21]
 LDCM0021  THZ1 HCT 116 C252(1.13)  LDD2173  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ATP-dependent RNA helicase DDX3X (DDX3X) DEAD box helicase family O00571
ATP-dependent RNA helicase A (DHX9) DEAD box helicase family Q08211
Baculoviral IAP repeat-containing protein 2 (BIRC2) IAP family Q13490
Nucleoside diphosphate kinase, mitochondrial (NME4) NDK family O00746
Bleomycin hydrolase (BLMH) Peptidase C1 family Q13867
Dual specificity protein kinase CLK2 (CLK2) CMGC Ser/Thr protein kinase family P49760
Dual specificity protein kinase CLK3 (CLK3) CMGC Ser/Thr protein kinase family P49761
GTP-binding protein 2 (GTPBP2) Classic translation factor GTPase family Q9BX10
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
THO complex subunit 4 (ALYREF) ALYREF family Q86V81
Beclin-1 (BECN1) Beclin family Q14457
Nuclear pore glycoprotein p62 (NUP62) Nucleoporin NSP1/NUP62 family P37198
Transcription factor
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-A1 (HOXA1) Antp homeobox family P49639
Transcription regulator protein BACH2 (BACH2) BZIP family Q9BYV9
Zinc finger protein 343 (ZNF343) Krueppel C2H2-type zinc-finger protein family Q6P1L6
Zinc finger protein 438 (ZNF438) Krueppel C2H2-type zinc-finger protein family Q7Z4V0
Other
Click To Hide/Show 44 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Aurora kinase A- and ninein-interacting protein (AUNIP) AUNIP family Q9H7T9
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 (TNFAIP1) BACURD family Q13829
Thyroid hormone receptor-associated protein 3 (THRAP3) BCLAF1/THRAP3 family Q9Y2W1
cAMP-dependent protein kinase type I-beta regulatory subunit (PRKAR1B) CAMP-dependent kinase regulatory chain family P31321
Segment polarity protein dishevelled homolog DVL-3 (DVL3) DSH family Q92997
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial (ECSIT) ECSIT family Q9BQ95
Endophilin-B2 (SH3GLB2) Endophilin family Q9NR46
Splicing factor ESS-2 homolog (ESS2) ESS2 family Q96DF8
Protein FAM9A (FAM9A) FAM9 family Q8IZU1
Golgin subfamily A member 6-like protein 9 (GOLGA6L9) GOLGA6 family A6NEM1
Glial fibrillary acidic protein (GFAP) Intermediate filament family P14136
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Peripherin (PRPH) Intermediate filament family P41219
Late cornified envelope protein 3E (LCE3E) LCE family Q5T5B0
Protein LDOC1 (LDOC1) LDOC1 family O95751
Methyl-CpG-binding domain protein 3-like 1 (MBD3L1) MBD3L family Q8WWY6
MRN complex-interacting protein (MRNIP) MRNIP family Q6NTE8
PIH1 domain-containing protein 2 (PIH1D2) PIH1 family Q8WWB5
SLAIN motif-containing protein 1 (SLAIN1) SLAIN motif-containing family Q8ND83
SNW domain-containing protein 1 (SNW1) SNW family Q13573
Serine/arginine-rich splicing factor 1 (SRSF1) Splicing factor SR family Q07955
Serine/arginine-rich splicing factor 3 (SRSF3) Splicing factor SR family P84103
Serine/arginine-rich splicing factor 7 (SRSF7) Splicing factor SR family Q16629
T-complex protein 10A homolog 1 (TCP10L) TCP10 family Q8TDR4
TRAF-interacting protein with FHA domain-containing protein A (TIFA) TIFA family Q96CG3
Vasculin (GPBP1) Vasculin family Q86WP2
Synaptonemal complex protein 3 (SYCP3) XLR/SYCP3 family Q8IZU3
Bridging integrator 3 (BIN3) . Q9NQY0
BTB/POZ domain-containing protein 18 (BTBD18) . B2RXH4
Chromatin target of PRMT1 protein (CHTOP) . Q9Y3Y2
Chromodomain Y-like protein 2 (CDYL2) . Q8N8U2
Coiled-coil domain-containing protein 120 (CCDC120) . Q96HB5
Heat shock factor 2-binding protein (HSF2BP) . O75031
KATNB1-like protein 1 (KATNBL1) . Q9H079
NTF2-related export protein 1 (NXT1) . Q9UKK6
Proline-rich protein 3 (PRR3) . P79522
Protein phosphatase 1 regulatory subunit 12C (PPP1R12C) . Q9BZL4
Regulator of DNA class I crossover intermediates 1 (REDIC1) . Q86WS4
TBC1 domain family member 14 (TBC1D14) . Q9P2M4
Testis-expressed protein 9 (TEX9) . Q8N6V9
Ubiquilin-1 (UBQLN1) . Q9UMX0
Uncharacterized protein C10orf55 (C10orf55) . Q5SWW7
Uncharacterized protein CCDC197 (CCDC197) . Q8NCU1
Uncharacterized protein NKAPD1 (NKAPD1) . Q6ZUT1

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
13 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
14 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
15 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
16 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
17 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
18 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
19 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
20 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
21 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.