Details of the Target

General Information of Target

Target ID LDTP14108
Target Name Nucleoside diphosphate kinase homolog 7 (NME7)
Gene Name NME7
Gene ID 29922
Synonyms
Nucleoside diphosphate kinase homolog 7; NDK 7; NDP kinase homolog 7; 3'-5' exonuclease NME7; EC 3.1.-.-; Protein kinase NME7; EC 2.7.-.-; nm23-H7
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFRKARRVNVRKRNDSEEEERERDEEQEPPPLLPPPGTGEEAGPGGGDRAPGGESLLGPG
PSPPSALTPGLGAEAGGGFPGGAEPGNGLKPRKRPRENKEVPRASLLSFQDEEEENEEVF
KVKKSSYSKKIVKLLKKEYKEDLEKSKIKTELNSSAESEQPLDKTGHVKDTNQEDGVIIS
EHGEDEMDMESEKEEEKPKTGGAFSNALSSLNVLRPGEIPDAAFIHAARKKRQMARELGD
FTPHDNEPGKGRLVREDENDASDDEDDDEKRRIVFSVKEKSQRQKIAEEIGIEGSDDDAL
VTGEQDEELSRWEQEQIRKGINIPQVQASQPAEVNMYYQNTYQTMPYGSSYGIPYSYTAY
GSSDAKSQKTDNTVPFKTPSNEMTPVTIDLVKKQLKDRLDSMKELHKTNRQQHEKHLQSR
VDSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQRA
SRLVQRRQDDIKDESSEFSSHSNKALMAPNLDSFGRDRALYQEHAKRRIAEREARRTRRR
QAREQTGKMADHLEGLSSDDEETSTDITNFNLEKDRISKESGKVFEDVLESFYSIDCIKS
QFEAWRSKYYTSYKDAYIGLCLPKLFNPLIRLQLLTWTPLEAKCRDFENMLWFESLLFYG
CEEREQEKDDVDVALLPTIVEKVILPKLTVIAENMWDPFSTTQTSRMVGITLKLINGYPS
VVNAENKNTQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFFQRQFWSSVKLL
GNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQNVINCFPKQWFMNL
KGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLLASVRALDHAMS
VASDHNVKEFKSLIEGK
Target Bioclass
Enzyme
Family
NDK family
Subcellular location
Cytoplasm, cytoskeleton, cilium axoneme
Function
Possesses an intrinsic kinase activity. Displays 3'-5' exonuclease activity with a preference for single-stranded DNA. Does not seem to have nucleoside diphosphate kinase activity. Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. Functional component of the gamma-tubulin ring complex, implicated in the regulation of the microtubule-nucleating activity of the gamma-tubulin ring complex in centrosomes, in a kinase activity-dependent manner.
Uniprot ID
Q9Y5B8
Ensemble ID
ENST00000367811.8
HGNC ID
HGNC:20461

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HUH28 SNV: p.S129Ter .
REH SNV: p.A184T DBIA    Probe Info 
TCCSUP SNV: p.C228Y DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.84  LDD0402  [1]
Acrolein
 Probe Info  		N.A.  LDD0221  [2]
DBIA
 Probe Info  		C228(1.20)  LDD0080  [3]
ATP probe
 Probe Info  		N.A.  LDD0199  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		C356(0.00); C325(0.00); C228(0.00)  LDD0038  [5]
IA-alkyne
 Probe Info  		C325(0.00); C228(0.00); C356(0.00)  LDD0036  [5]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [6]
Lodoacetamide azide
 Probe Info  		C228(0.00); C356(0.00)  LDD0037  [5]
IPM
 Probe Info  		C228(0.00); C170(0.00)  LDD2156  [7]
AOyne
 Probe Info  		9.80  LDD0443  [8]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C196
 Probe Info  		16.22  LDD1872  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C170(1.09); C228(1.03)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C170(0.94); C228(1.14); C239(1.12); C241(1.12)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C170(0.87); C228(0.94); C239(0.48); C241(0.48)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C170(0.97); C228(1.02); C239(0.34); C241(0.34)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C170(0.88); C228(0.97); C239(0.42); C241(0.42)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C170(1.20); C228(0.97); C239(0.28); C241(0.28)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C170(1.05); C228(1.01); C239(0.64); C241(0.64)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C170(1.21); C228(0.98); C239(0.39); C241(0.39)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C170(1.17); C228(0.97); C239(0.33); C241(0.33)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C170(1.15); C228(1.05); C239(0.42); C241(0.42)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C170(0.79); C228(0.91); C239(0.44); C241(0.44)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C170(0.78); C228(0.91); C239(0.76); C241(0.76)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C170(0.94); C228(1.07); C239(1.48); C241(1.48)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C170(0.73); C228(0.89); C239(0.39); C241(0.39)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C170(0.79); C228(0.93); C239(0.32); C241(0.32)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C170(0.97); C228(1.10); C239(0.38); C241(0.38)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C228(0.85)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C228(0.84)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C228(0.94)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C228(0.91)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C228(1.09)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C228(1.07)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C228(0.91)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C170(0.81); C228(1.06); C239(1.25); C241(1.25)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C228(0.98)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C228(0.84)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C228(1.07)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C228(0.87)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C228(0.97)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C228(1.07)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C228(1.23)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C228(1.12)  LDD0562  [3]
 LDCM0246  AC128 HCT 116 C170(1.15); C228(1.05)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C170(1.02); C228(1.03)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C170(1.24); C228(1.12)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C170(1.05); C228(1.09)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C170(1.31); C228(1.05)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C170(1.23); C228(1.13)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C170(1.27); C228(1.17)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C170(1.23); C228(1.03)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C170(1.22); C228(1.04)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C170(1.17); C228(1.02)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C170(1.25); C228(1.04)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C170(1.39); C228(1.09)  LDD0575  [3]
 LDCM0259  AC14 HCT 116 C170(0.83); C228(1.02); C239(1.21); C241(1.21)  LDD0576  [3]
 LDCM0260  AC140 HCT 116 C170(1.40); C228(1.20)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C170(1.35); C228(1.10)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C170(1.24); C228(1.01)  LDD0579  [3]
 LDCM0263  AC143 HCT 116 C170(0.91); C239(1.01); C241(1.01); C242(1.01)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C239(0.82); C241(0.88); C242(1.04); C228(1.12)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C241(0.76); C170(0.94); C242(0.94); C239(1.07)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C241(1.08); C239(1.09); C170(1.09); C228(1.11)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C241(0.77); C242(0.89); C170(1.01); C239(1.08)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C241(0.83); C239(1.08); C170(1.15); C228(1.21)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C241(0.78); C170(1.06); C239(1.12); C242(1.17)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C170(0.87); C239(1.01); C241(1.01); C242(1.01)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C241(0.83); C170(0.88); C242(1.12); C239(1.12)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C241(0.89); C242(1.11); C239(1.12); C228(1.23)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C242(0.82); C241(0.88); C170(0.91); C239(1.05)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C241(0.86); C228(1.02); C170(1.12); C242(1.15)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C170(1.00); C228(1.12); C239(1.14); C241(0.84)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C170(1.09); C228(1.47); C239(1.06); C241(0.94)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C170(0.82); C228(1.05); C239(1.38); C241(1.07)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C170(0.80); C228(1.04); C239(1.02); C241(0.84)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C228(1.04)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C228(1.14)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C228(1.15)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C228(1.08); C170(1.11)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C228(1.08)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C228(1.07)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C228(1.06)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C228(1.00)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C228(1.00)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C228(0.95); C239(1.20); C241(1.20); C242(1.20)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C228(0.97); C239(1.03); C241(1.03); C242(1.03)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C239(1.00); C241(1.00); C242(1.00); C228(1.08)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C239(1.12); C241(1.12); C242(1.12); C228(1.15)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C239(0.51); C241(0.51); C242(0.51); C228(0.99)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C228(1.02); C170(1.12)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C239(0.46); C241(0.46); C242(0.46); C228(1.09)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C239(0.65); C241(0.65); C242(0.65); C228(1.02)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C239(0.49); C241(0.49); C242(0.49); C228(1.12)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C239(0.77); C241(0.77); C242(0.77); C228(1.09)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C239(0.94); C241(0.94); C242(0.94); C228(1.08)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C170(0.92); C228(0.93)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C170(0.90); C228(0.99)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C228(0.95); C170(0.98)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C170(0.82); C228(0.94)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C170(0.90); C228(1.02)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C228(1.08); C170(1.17)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C170(0.80); C228(1.04)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C170(0.89); C228(1.00)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C170(0.72); C228(1.11)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C170(0.89); C228(1.11)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C170(0.82); C228(1.14)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C170(0.87); C228(1.04)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C228(1.05); C170(1.38)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C170(0.98); C228(1.02)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C228(0.99); C170(1.20)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C228(0.99); C170(1.39)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C228(1.06); C170(1.19)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C228(0.97); C170(1.38)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C228(0.84); C170(1.06)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C228(1.00); C170(1.06)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C228(1.00); C170(1.05)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C228(1.01); C170(1.05)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C170(0.94); C228(1.05)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C170(0.98); C228(1.14)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C239(0.50); C241(0.50); C170(1.24)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C239(0.40); C241(0.40); C170(1.15)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C239(0.39); C241(0.39); C170(1.35)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C239(0.82); C241(0.82); C242(0.82); C170(0.96)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C239(0.51); C241(0.51); C170(1.28)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C239(0.41); C241(0.41); C170(1.26)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C239(0.32); C241(0.32); C170(1.50)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C239(0.48); C241(0.48); C170(1.22)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C239(0.40); C241(0.40); C170(1.53)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C239(0.63); C241(0.63); C170(1.47)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C239(0.58); C241(0.58); C170(1.36)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C239(0.19); C241(0.19); C170(1.49)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C170(0.79); C228(1.09)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C170(0.77); C228(0.90)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C170(0.89); C228(0.99); C239(1.04); C241(1.04)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C228(0.92); C170(1.18)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C170(0.90); C228(1.02)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C228(0.97); C170(1.06)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C228(0.92); C170(1.10)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C228(0.93); C170(0.98)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C228(0.93); C170(1.05)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C170(0.95); C228(0.96)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C170(0.73); C228(0.91)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C170(0.77); C228(0.89)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C170(1.00); C228(1.06)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C170(0.98); C239(1.01); C241(1.01); C242(1.01)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C228(1.09); C170(1.11)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C170(0.93); C228(1.01)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C228(0.87); C170(1.10)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C170(1.07); C228(1.21)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C170(1.10); C228(1.20)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C228(1.07); C170(1.39)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C228(1.10); C170(1.15)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C228(1.02); C170(1.14)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C170(0.97); C228(1.08)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C228(1.13); C170(1.20)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C228(0.98); C170(1.21)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C170(1.01); C228(1.15)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C170(0.93); C228(1.16)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C228(1.17); C170(1.24)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C228(1.04); C170(1.45)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C170(1.07); C228(1.11)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C228(1.06); C170(1.31)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C170(1.12); C228(1.14)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C239(0.31); C241(0.31); C242(0.31); C228(0.86)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C239(0.33); C241(0.33); C242(0.33); C228(0.83)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C170(0.93); C228(1.15); C239(1.22); C241(1.22)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C170(0.85); C228(1.16); C239(1.20); C241(1.20)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C239(0.89); C241(0.89); C242(0.89); C170(1.00)  LDD0592  [3]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [2]
 LDCM0367  CL1 HCT 116 C170(0.95); C228(1.10)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C228(1.06); C170(1.08)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C228(1.02); C170(1.09)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C170(0.98); C239(1.01); C241(1.01); C242(1.01)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C170(0.83); C228(1.01); C239(1.18); C241(1.18)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C228(0.92); C170(0.93); C239(1.42); C241(1.42)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C170(0.87); C228(1.02); C239(1.04); C241(1.04)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C228(1.15)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C228(1.20)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C228(1.29)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C228(1.27)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C228(1.16)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C228(0.99); C170(1.10)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C228(1.15)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C228(1.16)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C239(0.80); C241(0.80); C242(0.80); C228(1.02)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C239(0.39); C241(0.39); C242(0.39); C228(1.04)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C239(0.39); C241(0.39); C242(0.39); C228(0.93)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C239(0.54); C241(0.54); C242(0.54); C228(1.07)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C239(0.70); C241(0.70); C242(0.70); C228(1.11)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C170(0.59); C228(0.93)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C228(1.08); C170(1.16)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C228(1.07); C170(1.13)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C228(1.15); C170(1.49)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C228(1.04); C170(1.05)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C170(1.19); C228(1.26)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C170(1.02); C228(1.05)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C170(0.88); C228(1.11)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C228(1.07); C170(1.08)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C239(1.03); C241(1.03); C170(1.14)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C170(1.03); C239(1.04); C241(1.04)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C239(0.88); C241(0.88); C170(1.04)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C239(0.55); C241(0.55); C170(1.38)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C228(1.04); C170(1.18)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C170(1.03); C228(1.19)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C228(0.97); C170(1.17)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C239(0.82); C241(0.82); C242(0.82); C170(0.94)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C228(0.99); C170(1.16)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C170(1.18); C228(1.23)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C228(1.20); C170(1.28)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C170(0.95); C228(1.03)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C228(1.18); C170(1.43)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C228(1.16); C170(1.55)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C228(1.06); C170(1.64)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C170(1.28); C228(1.29)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C228(1.40); C170(1.47)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C170(1.18); C228(1.30)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C170(1.20); C228(1.16)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C170(1.48); C228(1.18)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C170(1.36); C228(1.33)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C170(1.32); C228(1.23)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C170(1.18); C228(0.94)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C170(1.15); C228(1.11)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C170(1.23); C228(1.13)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C170(1.06); C228(1.15); C239(0.40); C241(0.40)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C170(1.10); C228(0.96); C239(0.90); C241(0.90)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C170(1.21); C228(1.24); C239(0.69); C241(0.69)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C170(1.27); C228(1.12); C239(1.10); C241(1.10)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C170(0.98); C228(1.00); C239(0.89); C241(0.89)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C170(1.03); C228(1.23); C239(0.85); C241(0.85)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C170(1.16); C228(1.21); C239(0.85); C241(0.85)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C170(1.10); C228(1.00)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C170(0.99); C228(1.07); C239(0.93); C241(0.93)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C170(1.00); C228(1.05); C239(0.63); C241(0.63)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C170(0.96); C228(1.17); C239(0.83); C241(0.83)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C170(1.08); C228(1.04); C239(0.75); C241(0.75)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C170(1.15); C228(0.99); C239(0.99); C241(0.99)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C170(1.13); C228(1.11); C239(1.32); C241(1.32)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C170(1.46); C228(0.98)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C170(1.12); C228(0.86)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C170(1.19); C228(0.89)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C170(1.32); C228(0.89)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C170(1.14); C228(1.21)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C170(0.99); C228(0.88)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C170(1.32); C228(0.93)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C170(1.37); C228(0.88)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C170(0.95); C228(0.91)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C170(1.20); C228(0.79)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C170(1.19); C228(0.77)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C170(1.10); C228(0.88)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C170(1.10); C228(0.82)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C170(1.43); C228(0.81)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C170(1.15); C228(0.91)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C170(1.19); C228(1.04)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C170(1.53); C228(0.87)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C170(1.22); C228(1.10)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C170(1.23); C228(1.10)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C170(0.71); C228(1.15)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C170(1.20); C228(1.19)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C170(0.81); C228(1.13)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C170(0.97); C228(1.50)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C170(0.66); C228(1.21)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C170(0.62); C228(1.08)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C170(0.92); C228(0.97)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C170(1.30); C228(1.21)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C170(0.90); C228(1.07)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C170(0.76); C228(1.24)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C170(0.85); C228(1.09)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C170(0.80); C228(1.16)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C170(0.74); C228(1.14)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C170(1.00); C228(1.09)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C170(0.87); C228(0.89)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C170(1.02); C228(1.17)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C170(1.16); C228(1.21)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C170(1.35); C228(1.02)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C170(0.95); C228(0.98)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C170(1.04); C228(1.29)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C170(1.31); C228(1.29)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C170(1.26); C228(1.30)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C170(1.22); C228(1.16)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C170(1.13); C228(1.22)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C170(0.97); C228(1.14)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C170(1.19); C228(1.18)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C170(1.24); C228(1.33)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C170(1.29); C228(1.20)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C170(1.29); C228(0.88)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C170(0.95); C228(0.94)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C170(1.15); C228(1.08)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C170(0.97); C228(0.92)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C170(1.00); C228(0.91)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C170(1.01); C228(1.07)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C170(1.04); C228(1.05)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C170(1.08); C228(1.10)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C170(1.09); C228(0.97)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C170(1.21); C228(1.04)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C170(1.14); C228(1.09)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C170(1.03)  LDD1698  [10]
 LDCM0468  Fragment33 HCT 116 C170(0.91); C228(1.16)  LDD0785  [3]
 LDCM0427  Fragment51 HCT 116 C170(0.89); C228(1.07); C239(1.20); C241(1.20)  LDD0744  [3]
 LDCM0107  IAA HeLa N.A.  LDD0221  [2]
 LDCM0022  KB02 HCT 116 C228(1.20)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C228(1.17)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C228(1.22)  LDD0082  [3]
 LDCM0109  NEM HeLa N.A.  LDD0224  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cytosolic purine 5'-nucleotidase (NT5C2) 5'(3')-deoxyribonucleotidase family P49902
NIF3-like protein 1 (NIF3L1) GTP cyclohydrolase I type 2/NIF3 family Q9GZT8
Nucleoside diphosphate kinase, mitochondrial (NME4) NDK family O00746
Proteasome subunit alpha type-1 (PSMA1) Peptidase T1A family P25786
E3 ubiquitin-protein ligase TRIM48 (TRIM48) TRIM/RBCC family Q8IWZ4
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Flotillin-1 (FLOT1) Band 7/mec-2 family O75955
SNARE-associated protein Snapin (SNAPIN) SNAPIN family O95295
Sorting nexin-32 (SNX32) Sorting nexin family Q86XE0
AP-4 complex accessory subunit Tepsin (TEPSIN) . Q96N21
Transcription factor
Click To Hide/Show 16 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Fos-related antigen 1 (FOSL1) BZIP family P15407
Fos-related antigen 2 (FOSL2) BZIP family P15408
Zinc finger protein GLIS2 (GLIS2) GLI C2H2-type zinc-finger protein family Q9BZE0
Zinc finger protein Aiolos (IKZF3) Ikaros C2H2-type zinc-finger protein family Q9UKT9
Telomere zinc finger-associated protein (ZBTB48) Krueppel C2H2-type zinc-finger protein family P10074
Zinc finger protein 23 (ZNF23) Krueppel C2H2-type zinc-finger protein family P17027
Zinc finger protein 343 (ZNF343) Krueppel C2H2-type zinc-finger protein family Q6P1L6
Zinc finger protein 526 (ZNF526) Krueppel C2H2-type zinc-finger protein family Q8TF50
Zinc finger protein 620 (ZNF620) Krueppel C2H2-type zinc-finger protein family Q6ZNG0
Homeobox protein goosecoid-2 (GSC2) Paired homeobox family O15499
POU domain, class 6, transcription factor 2 (POU6F2) POU transcription factor family P78424
NF-kappa-B inhibitor-like protein 1 (NFKBIL1) . Q9UBC1
Proto-oncogene c-Rel (REL) . Q04864
THAP domain-containing protein 10 (THAP10) . Q9P2Z0
Transcription factor 4 (TCF4) . P15884
Transcriptional repressor p66-beta (GATAD2B) . Q8WXI9
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Myotilin (MYOT) Myotilin/palladin family Q9UBF9
Other
Click To Hide/Show 31 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Angiomotin-like protein 2 (AMOTL2) Angiomotin family Q9Y2J4
Cdc42 effector protein 2 (CDC42EP2) BORG/CEP family O14613
Coiled-coil domain-containing protein 88B (CCDC88B) CCDC88 family A6NC98
Centrosomal protein of 72 kDa (CEP72) CEP72 family Q9P209
DNA damage-inducible transcript 4-like protein (DDIT4L) DDIT4 family Q96D03
Dynein axonemal intermediate chain 7 (DNAI7) DNAI7 family Q6TDU7
Inactive peptidyl-prolyl cis-trans isomerase FKBP6 (FKBP6) FKBP6 family O75344
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
HAUS augmin-like complex subunit 8 (HAUS8) HAUS8 family Q9BT25
Protein INCA1 (INCA1) INCA family Q0VD86
Keratin, type I cytoskeletal 18 (KRT18) Intermediate filament family P05783
Keratin, type II cytoskeletal 75 (KRT75) Intermediate filament family O95678
Neurofilament light polypeptide (NEFL) Intermediate filament family P07196
Mediator of RNA polymerase II transcription subunit 11 (MED11) Mediator complex subunit 11 family Q9P086
Mediator of RNA polymerase II transcription subunit 30 (MED30) Mediator complex subunit 30 family Q96HR3
Meiosis-specific protein MEI4 (MEI4) MEI4L family A8MW99
NGFI-A-binding protein 2 (NAB2) NAB family Q15742
Centriole and centriolar satellite protein OFD1 (OFD1) OFD1 family O75665
Shootin-1 (SHTN1) Shootin family A0MZ66
Synaptonemal complex central element protein 1 (SYCE1) SYCE family Q8N0S2
Trichoplein keratin filament-binding protein (TCHP) TCHP family Q9BT92
Tektin-1 (TEKT1) Tektin family Q969V4
Troponin I, fast skeletal muscle (TNNI2) Troponin I family P48788
Caspase recruitment domain-containing protein 10 (CARD10) . Q9BWT7
Cilia- and flagella-associated protein 141 (CFAP141) . Q5VU69
EF-hand domain-containing family member C2 (EFHC2) . Q5JST6
PRKCA-binding protein (PICK1) . Q9NRD5
Proline and serine-rich protein 3 (PROSER3) . Q2NL68
Rho GTPase-activating protein 9 (ARHGAP9) . Q9BRR9
Run domain Beclin-1-interacting and cysteine-rich domain-containing protein (RUBCN) . Q92622
TNFAIP3-interacting protein 1 (TNIP1) . Q15025

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
7 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402