Details of the Target

General Information of Target

Target ID LDTP00874
Target Name Glutathione S-transferase LANCL1 (LANCL1)
Gene Name LANCL1
Gene ID 10314
Synonyms
GPR69A; Glutathione S-transferase LANCL1; EC 2.5.1.18; 40 kDa erythrocyte membrane protein; p40; LanC-like protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAQRAFPNPYADYNKSLAEGYFDAAGRLTPEFSQRLTNKIRELLQQMERGLKSADPRDGT
GYTGWAGIAVLYLHLYDVFGDPAYLQLAHGYVKQSLNCLTKRSITFLCGDAGPLAVAAVL
YHKMNNEKQAEDCITRLIHLNKIDPHAPNEMLYGRIGYIYALLFVNKNFGVEKIPQSHIQ
QICETILTSGENLARKRNFTAKSPLMYEWYQEYYVGAAHGLAGIYYYLMQPSLQVSQGKL
HSLVKPSVDYVCQLKFPSGNYPPCIGDNRDLLVHWCHGAPGVIYMLIQAYKVFREEKYLC
DAYQCADVIWQYGLLKKGYGLCHGSAGNAYAFLTLYNLTQDMKYLYRACKFAEWCLEYGE
HGCRTPDTPFSLFEGMAGTIYFLADLLVPTKARFPAFEL
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
LanC-like protein family
Subcellular location
Cytoplasm
Function
Functions as a glutathione transferase. Catalyzes conjugation of the glutathione (GSH) to artificial substrates 1-chloro-2,4-dinitrobenzene (CDNB) and p-nitrophenyl acetate. Mitigates neuronal oxidative stress during normal postnatal development and in response to oxidative stresses probably through GSH antioxidant defense mechanism. May play a role in EPS8 signaling. Binds glutathione.
TTD ID
T97637
Uniprot ID
O43813
DrugMap ID
TTZW8NS
Ensemble ID
ENST00000233714.8
HGNC ID
HGNC:6508

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 21 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		10.19  LDD0402  [1]
TH211
 Probe Info  		Y21(14.30)  LDD0260  [2]
IPM
 Probe Info  		N.A.  LDD0241  [3]
Probe 1
 Probe Info  		Y13(16.39); Y21(32.39)  LDD3495  [4]
BTD
 Probe Info  		C133(0.74)  LDD2117  [5]
AHL-Pu-1
 Probe Info  		C133(2.89)  LDD0168  [6]
DBIA
 Probe Info  		C363(41.25)  LDD0209  [7]
5E-2FA
 Probe Info  		H146(0.00); H178(0.00)  LDD2235  [8]
ATP probe
 Probe Info  		N.A.  LDD0199  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		C264(0.00); C322(0.00); C183(0.00); C252(0.00)  LDD0038  [10]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [11]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [12]
IPIAA_L
 Probe Info  		C355(0.00); C183(0.00)  LDD0031  [12]
Lodoacetamide azide
 Probe Info  		C276(0.00); C264(0.00); C322(0.00); C183(0.00)  LDD0037  [10]
TFBX
 Probe Info  		N.A.  LDD0148  [13]
1c-yne
 Probe Info  		N.A.  LDD0228  [14]
Acrolein
 Probe Info  		C252(0.00); C183(0.00); C264(0.00); C133(0.00)  LDD0217  [15]
Methacrolein
 Probe Info  		N.A.  LDD0218  [15]
W1
 Probe Info  		C252(0.00); C183(0.00); C264(0.00)  LDD0236  [3]
AOyne
 Probe Info  		10.00  LDD0443  [16]
NAIA_5
 Probe Info  		C183(0.00); C252(0.00); C133(0.00); C108(0.00)  LDD2223  [17]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-2
 Probe Info  		N.A.  LDD0138  [18]
BD-F
 Probe Info  		Y214(0.00); Q211(0.00); Y207(0.00)  LDD0024  [19]
STS-1
 Probe Info  		N.A.  LDD0068  [20]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C133(0.74)  LDD2117  [5]
 LDCM0025  4SU-RNA HEK-293T C133(2.89)  LDD0168  [6]
 LDCM0214  AC1 PaTu 8988t C264(0.39); C363(1.39)  LDD1093  [21]
 LDCM0215  AC10 HEK-293T C264(1.11)  LDD0813  [21]
 LDCM0216  AC100 PaTu 8988t C264(2.37)  LDD1095  [21]
 LDCM0217  AC101 PaTu 8988t C264(2.25)  LDD1096  [21]
 LDCM0218  AC102 PaTu 8988t C264(2.89)  LDD1097  [21]
 LDCM0219  AC103 PaTu 8988t C264(2.59)  LDD1098  [21]
 LDCM0220  AC104 PaTu 8988t C264(2.34)  LDD1099  [21]
 LDCM0221  AC105 PaTu 8988t C264(1.20)  LDD1100  [21]
 LDCM0222  AC106 PaTu 8988t C264(1.86)  LDD1101  [21]
 LDCM0223  AC107 PaTu 8988t C264(1.32)  LDD1102  [21]
 LDCM0224  AC108 PaTu 8988t C264(1.55)  LDD1103  [21]
 LDCM0225  AC109 PaTu 8988t C264(2.32)  LDD1104  [21]
 LDCM0226  AC11 HEK-293T C264(1.26)  LDD0824  [21]
 LDCM0227  AC110 PaTu 8988t C264(2.02)  LDD1106  [21]
 LDCM0228  AC111 PaTu 8988t C264(2.78)  LDD1107  [21]
 LDCM0229  AC112 PaTu 8988t C264(2.22)  LDD1108  [21]
 LDCM0230  AC113 PaTu 8988t C300(0.93)  LDD1109  [21]
 LDCM0231  AC114 PaTu 8988t C300(1.06)  LDD1110  [21]
 LDCM0232  AC115 PaTu 8988t C300(0.68)  LDD1111  [21]
 LDCM0233  AC116 PaTu 8988t C300(0.95)  LDD1112  [21]
 LDCM0234  AC117 PaTu 8988t C300(0.72)  LDD1113  [21]
 LDCM0235  AC118 PaTu 8988t C300(0.71)  LDD1114  [21]
 LDCM0236  AC119 PaTu 8988t C300(0.53)  LDD1115  [21]
 LDCM0237  AC12 HEK-293T C264(0.98)  LDD0835  [21]
 LDCM0238  AC120 PaTu 8988t C300(0.72)  LDD1117  [21]
 LDCM0239  AC121 PaTu 8988t C300(0.54)  LDD1118  [21]
 LDCM0240  AC122 PaTu 8988t C300(0.82)  LDD1119  [21]
 LDCM0241  AC123 PaTu 8988t C300(0.55)  LDD1120  [21]
 LDCM0242  AC124 PaTu 8988t C300(0.51)  LDD1121  [21]
 LDCM0243  AC125 PaTu 8988t C300(0.66)  LDD1122  [21]
 LDCM0244  AC126 PaTu 8988t C300(0.55)  LDD1123  [21]
 LDCM0245  AC127 PaTu 8988t C300(0.50)  LDD1124  [21]
 LDCM0246  AC128 PaTu 8988t C363(1.49)  LDD1125  [21]
 LDCM0247  AC129 PaTu 8988t C363(1.23)  LDD1126  [21]
 LDCM0249  AC130 PaTu 8988t C363(0.98)  LDD1128  [21]
 LDCM0250  AC131 PaTu 8988t C363(1.06)  LDD1129  [21]
 LDCM0251  AC132 PaTu 8988t C363(0.94)  LDD1130  [21]
 LDCM0252  AC133 PaTu 8988t C363(0.72)  LDD1131  [21]
 LDCM0253  AC134 PaTu 8988t C363(0.67)  LDD1132  [21]
 LDCM0254  AC135 PaTu 8988t C363(0.43)  LDD1133  [21]
 LDCM0255  AC136 PaTu 8988t C363(0.64)  LDD1134  [21]
 LDCM0256  AC137 PaTu 8988t C363(0.53)  LDD1135  [21]
 LDCM0257  AC138 PaTu 8988t C363(1.77)  LDD1136  [21]
 LDCM0258  AC139 PaTu 8988t C363(1.77)  LDD1137  [21]
 LDCM0259  AC14 HEK-293T C264(1.18)  LDD0857  [21]
 LDCM0260  AC140 PaTu 8988t C363(1.17)  LDD1139  [21]
 LDCM0261  AC141 PaTu 8988t C363(0.82)  LDD1140  [21]
 LDCM0262  AC142 PaTu 8988t C363(1.24)  LDD1141  [21]
 LDCM0263  AC143 PaTu 8988t C300(0.84); C363(1.15)  LDD1142  [21]
 LDCM0264  AC144 PaTu 8988t C300(0.68); C363(0.84)  LDD1143  [21]
 LDCM0265  AC145 PaTu 8988t C300(0.76); C363(1.08)  LDD1144  [21]
 LDCM0266  AC146 PaTu 8988t C300(0.77); C363(0.89)  LDD1145  [21]
 LDCM0267  AC147 PaTu 8988t C300(0.77); C363(1.50)  LDD1146  [21]
 LDCM0268  AC148 PaTu 8988t C300(0.72); C363(1.31)  LDD1147  [21]
 LDCM0269  AC149 PaTu 8988t C300(0.85); C363(1.52)  LDD1148  [21]
 LDCM0270  AC15 HEK-293T C264(1.08)  LDD0868  [21]
 LDCM0271  AC150 PaTu 8988t C300(0.63); C363(1.25)  LDD1150  [21]
 LDCM0272  AC151 PaTu 8988t C300(0.88); C363(1.74)  LDD1151  [21]
 LDCM0273  AC152 PaTu 8988t C300(0.52); C363(1.19)  LDD1152  [21]
 LDCM0274  AC153 PaTu 8988t C300(0.80); C363(0.92)  LDD1153  [21]
 LDCM0621  AC154 PaTu 8988t C300(0.59); C363(1.13)  LDD2166  [21]
 LDCM0622  AC155 PaTu 8988t C300(0.63); C363(1.04)  LDD2167  [21]
 LDCM0623  AC156 PaTu 8988t C300(0.40); C363(0.94)  LDD2168  [21]
 LDCM0624  AC157 PaTu 8988t C300(0.80); C363(0.94)  LDD2169  [21]
 LDCM0276  AC17 PaTu 8988t C363(2.56)  LDD1155  [21]
 LDCM0277  AC18 PaTu 8988t C363(1.65)  LDD1156  [21]
 LDCM0278  AC19 PaTu 8988t C363(1.32)  LDD1157  [21]
 LDCM0279  AC2 PaTu 8988t C264(0.40); C363(1.62)  LDD1158  [21]
 LDCM0280  AC20 PaTu 8988t C363(1.32)  LDD1159  [21]
 LDCM0281  AC21 PaTu 8988t C363(1.75)  LDD1160  [21]
 LDCM0282  AC22 PaTu 8988t C363(2.16)  LDD1161  [21]
 LDCM0283  AC23 PaTu 8988t C363(1.92)  LDD1162  [21]
 LDCM0284  AC24 PaTu 8988t C363(1.39)  LDD1163  [21]
 LDCM0285  AC25 PaTu 8988t C300(0.75)  LDD1164  [21]
 LDCM0286  AC26 PaTu 8988t C300(1.03)  LDD1165  [21]
 LDCM0287  AC27 PaTu 8988t C300(0.91)  LDD1166  [21]
 LDCM0288  AC28 PaTu 8988t C300(1.65)  LDD1167  [21]
 LDCM0289  AC29 PaTu 8988t C300(1.06)  LDD1168  [21]
 LDCM0290  AC3 PaTu 8988t C264(0.38); C363(1.28)  LDD1169  [21]
 LDCM0291  AC30 PaTu 8988t C300(1.02)  LDD1170  [21]
 LDCM0292  AC31 PaTu 8988t C300(0.85)  LDD1171  [21]
 LDCM0293  AC32 PaTu 8988t C300(0.56)  LDD1172  [21]
 LDCM0294  AC33 PaTu 8988t C300(1.29)  LDD1173  [21]
 LDCM0295  AC34 PaTu 8988t C300(0.65)  LDD1174  [21]
 LDCM0296  AC35 PaTu 8988t C264(1.37)  LDD1175  [21]
 LDCM0297  AC36 PaTu 8988t C264(1.40)  LDD1176  [21]
 LDCM0298  AC37 PaTu 8988t C264(1.05)  LDD1177  [21]
 LDCM0299  AC38 PaTu 8988t C264(1.12)  LDD1178  [21]
 LDCM0300  AC39 PaTu 8988t C264(1.45)  LDD1179  [21]
 LDCM0301  AC4 PaTu 8988t C264(0.41); C363(1.42)  LDD1180  [21]
 LDCM0302  AC40 PaTu 8988t C264(1.27)  LDD1181  [21]
 LDCM0303  AC41 PaTu 8988t C264(1.15)  LDD1182  [21]
 LDCM0304  AC42 PaTu 8988t C264(1.05)  LDD1183  [21]
 LDCM0305  AC43 PaTu 8988t C264(0.96)  LDD1184  [21]
 LDCM0306  AC44 PaTu 8988t C264(1.26)  LDD1185  [21]
 LDCM0307  AC45 PaTu 8988t C264(0.94)  LDD1186  [21]
 LDCM0308  AC46 HEK-293T C264(0.97); C252(1.01); C108(0.97); C133(0.94)  LDD1547  [22]
 LDCM0309  AC47 HEK-293T C264(1.06); C252(1.04); C183(1.26); C108(1.07)  LDD1548  [22]
 LDCM0310  AC48 HEK-293T C264(1.02); C252(1.03); C183(1.05); C108(1.09)  LDD1549  [22]
 LDCM0311  AC49 HEK-293T C264(0.95); C252(1.02); C183(0.98); C108(0.99)  LDD1550  [22]
 LDCM0312  AC5 PaTu 8988t C264(0.34); C363(1.30)  LDD1191  [21]
 LDCM0313  AC50 HEK-293T C264(0.85); C252(1.00); C183(1.23); C108(1.04)  LDD1552  [22]
 LDCM0314  AC51 HEK-293T C252(1.05); C183(1.04); C108(0.97); C276(0.87)  LDD1553  [22]
 LDCM0315  AC52 HEK-293T C264(0.99); C252(1.09); C183(1.02); C108(0.99)  LDD1554  [22]
 LDCM0316  AC53 HEK-293T C252(1.01); C183(0.95); C108(1.03); C276(0.86)  LDD1555  [22]
 LDCM0317  AC54 HEK-293T C264(1.18); C252(0.97); C108(0.99); C133(1.02)  LDD1556  [22]
 LDCM0318  AC55 HEK-293T C264(1.12); C252(1.05); C183(0.93); C108(1.01)  LDD1557  [22]
 LDCM0319  AC56 HEK-293T C264(1.05); C252(1.01); C183(1.01); C108(1.07)  LDD1558  [22]
 LDCM0320  AC57 PaTu 8988t C363(0.79)  LDD1199  [21]
 LDCM0321  AC58 PaTu 8988t C363(1.39)  LDD1200  [21]
 LDCM0322  AC59 PaTu 8988t C363(1.80)  LDD1201  [21]
 LDCM0323  AC6 HEK-293T C264(0.98)  LDD0921  [21]
 LDCM0324  AC60 PaTu 8988t C363(0.77)  LDD1203  [21]
 LDCM0325  AC61 PaTu 8988t C363(1.06)  LDD1204  [21]
 LDCM0326  AC62 PaTu 8988t C363(1.82)  LDD1205  [21]
 LDCM0327  AC63 PaTu 8988t C363(1.01)  LDD1206  [21]
 LDCM0328  AC64 PaTu 8988t C363(0.66)  LDD1207  [21]
 LDCM0329  AC65 PaTu 8988t C363(1.52)  LDD1208  [21]
 LDCM0330  AC66 PaTu 8988t C363(1.19)  LDD1209  [21]
 LDCM0331  AC67 PaTu 8988t C363(0.76)  LDD1210  [21]
 LDCM0334  AC7 HEK-293T C264(1.32)  LDD0932  [21]
 LDCM0345  AC8 HEK-293T C264(1.07)  LDD0943  [21]
 LDCM0349  AC83 HEK-293T C264(0.96)  LDD0947  [21]
 LDCM0350  AC84 HEK-293T C264(1.17)  LDD0948  [21]
 LDCM0351  AC85 HEK-293T C264(1.45)  LDD0949  [21]
 LDCM0352  AC86 HEK-293T C264(1.12)  LDD0950  [21]
 LDCM0353  AC87 HEK-293T C264(1.18)  LDD0951  [21]
 LDCM0354  AC88 HEK-293T C264(1.38)  LDD0952  [21]
 LDCM0355  AC89 HEK-293T C264(1.49)  LDD0953  [21]
 LDCM0357  AC90 HEK-293T C264(1.13)  LDD0955  [21]
 LDCM0358  AC91 HEK-293T C264(1.11)  LDD0956  [21]
 LDCM0359  AC92 HEK-293T C264(1.02)  LDD0957  [21]
 LDCM0360  AC93 HEK-293T C264(1.44)  LDD0958  [21]
 LDCM0361  AC94 HEK-293T C264(1.44)  LDD0959  [21]
 LDCM0362  AC95 HEK-293T C264(1.14)  LDD0960  [21]
 LDCM0363  AC96 HEK-293T C264(1.12)  LDD0961  [21]
 LDCM0364  AC97 HEK-293T C264(1.40)  LDD0962  [21]
 LDCM0365  AC98 PaTu 8988t C264(1.95)  LDD1244  [21]
 LDCM0366  AC99 PaTu 8988t C264(2.18)  LDD1245  [21]
 LDCM0248  AKOS034007472 HEK-293T C264(1.07)  LDD0846  [21]
 LDCM0356  AKOS034007680 HEK-293T C264(1.36)  LDD0954  [21]
 LDCM0275  AKOS034007705 HEK-293T C264(1.13)  LDD0873  [21]
 LDCM0156  Aniline NCI-H1299 10.36  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa C183(0.00); C252(0.00); C98(0.00)  LDD0222  [15]
 LDCM0367  CL1 PaTu 8988t C264(0.75); C363(1.00)  LDD1246  [21]
 LDCM0368  CL10 PaTu 8988t C264(0.93); C363(0.73)  LDD1247  [21]
 LDCM0369  CL100 PaTu 8988t C264(0.36); C363(1.08)  LDD1248  [21]
 LDCM0370  CL101 HEK-293T C264(1.13)  LDD0968  [21]
 LDCM0371  CL102 HEK-293T C264(1.12)  LDD0969  [21]
 LDCM0372  CL103 HEK-293T C264(1.20)  LDD0970  [21]
 LDCM0373  CL104 HEK-293T C264(1.16)  LDD0971  [21]
 LDCM0374  CL105 PaTu 8988t C363(1.47)  LDD1253  [21]
 LDCM0375  CL106 PaTu 8988t C363(1.42)  LDD1254  [21]
 LDCM0376  CL107 PaTu 8988t C363(1.77)  LDD1255  [21]
 LDCM0377  CL108 PaTu 8988t C363(0.75)  LDD1256  [21]
 LDCM0378  CL109 PaTu 8988t C363(1.56)  LDD1257  [21]
 LDCM0379  CL11 PaTu 8988t C264(0.88); C363(1.00)  LDD1258  [21]
 LDCM0380  CL110 PaTu 8988t C363(1.77)  LDD1259  [21]
 LDCM0381  CL111 PaTu 8988t C363(1.80)  LDD1260  [21]
 LDCM0382  CL112 PaTu 8988t C300(1.13)  LDD1261  [21]
 LDCM0383  CL113 PaTu 8988t C300(0.96)  LDD1262  [21]
 LDCM0384  CL114 PaTu 8988t C300(1.02)  LDD1263  [21]
 LDCM0385  CL115 PaTu 8988t C300(1.25)  LDD1264  [21]
 LDCM0386  CL116 PaTu 8988t C300(1.21)  LDD1265  [21]
 LDCM0387  CL117 PaTu 8988t C264(1.10)  LDD1266  [21]
 LDCM0388  CL118 PaTu 8988t C264(0.99)  LDD1267  [21]
 LDCM0389  CL119 PaTu 8988t C264(1.13)  LDD1268  [21]
 LDCM0390  CL12 PaTu 8988t C264(1.03); C363(0.95)  LDD1269  [21]
 LDCM0391  CL120 PaTu 8988t C264(1.31)  LDD1270  [21]
 LDCM0392  CL121 HEK-293T C264(0.86); C252(0.99); C183(1.12); C108(1.06)  LDD1596  [22]
 LDCM0393  CL122 HEK-293T C264(1.01); C252(1.02); C183(1.02); C108(0.93)  LDD1597  [22]
 LDCM0394  CL123 HEK-293T C264(1.06); C252(0.96); C183(1.02); C108(0.91)  LDD1598  [22]
 LDCM0395  CL124 HEK-293T C252(1.02); C183(0.96); C108(1.06); C276(1.00)  LDD1599  [22]
 LDCM0396  CL125 PaTu 8988t C363(0.99)  LDD1275  [21]
 LDCM0397  CL126 PaTu 8988t C363(1.71)  LDD1276  [21]
 LDCM0398  CL127 PaTu 8988t C363(1.34)  LDD1277  [21]
 LDCM0399  CL128 PaTu 8988t C363(1.65)  LDD1278  [21]
 LDCM0400  CL13 PaTu 8988t C264(1.18); C363(0.57)  LDD1279  [21]
 LDCM0401  CL14 PaTu 8988t C264(1.08); C363(0.46)  LDD1280  [21]
 LDCM0402  CL15 PaTu 8988t C264(0.99); C363(0.57)  LDD1281  [21]
 LDCM0403  CL16 HEK-293T C264(0.44)  LDD1001  [21]
 LDCM0404  CL17 HEK-293T C264(0.74)  LDD1002  [21]
 LDCM0405  CL18 HEK-293T C264(0.92)  LDD1003  [21]
 LDCM0406  CL19 HEK-293T C264(0.59)  LDD1004  [21]
 LDCM0407  CL2 PaTu 8988t C264(0.79); C363(0.75)  LDD1286  [21]
 LDCM0408  CL20 HEK-293T C264(0.59)  LDD1006  [21]
 LDCM0409  CL21 HEK-293T C264(0.87)  LDD1007  [21]
 LDCM0410  CL22 HEK-293T C264(0.68)  LDD1008  [21]
 LDCM0411  CL23 HEK-293T C264(0.47)  LDD1009  [21]
 LDCM0412  CL24 HEK-293T C264(0.58)  LDD1010  [21]
 LDCM0413  CL25 HEK-293T C264(0.63)  LDD1011  [21]
 LDCM0414  CL26 HEK-293T C264(0.70)  LDD1012  [21]
 LDCM0415  CL27 HEK-293T C264(0.69)  LDD1013  [21]
 LDCM0416  CL28 HEK-293T C264(0.63)  LDD1014  [21]
 LDCM0417  CL29 HEK-293T C264(0.55)  LDD1015  [21]
 LDCM0418  CL3 PaTu 8988t C264(1.03); C363(0.87)  LDD1297  [21]
 LDCM0419  CL30 HEK-293T C264(1.01)  LDD1017  [21]
 LDCM0420  CL31 HEK-293T C264(0.88)  LDD1018  [21]
 LDCM0421  CL32 HEK-293T C264(1.03)  LDD1019  [21]
 LDCM0422  CL33 HEK-293T C264(0.97)  LDD1020  [21]
 LDCM0423  CL34 HEK-293T C264(0.88)  LDD1021  [21]
 LDCM0424  CL35 HEK-293T C264(0.94)  LDD1022  [21]
 LDCM0425  CL36 HEK-293T C264(1.11)  LDD1023  [21]
 LDCM0426  CL37 HEK-293T C264(1.02)  LDD1024  [21]
 LDCM0428  CL39 HEK-293T C264(1.29)  LDD1026  [21]
 LDCM0429  CL4 PaTu 8988t C264(0.82); C363(1.19)  LDD1308  [21]
 LDCM0430  CL40 HEK-293T C264(1.06)  LDD1028  [21]
 LDCM0431  CL41 HEK-293T C264(1.26)  LDD1029  [21]
 LDCM0432  CL42 HEK-293T C264(1.40)  LDD1030  [21]
 LDCM0433  CL43 HEK-293T C264(1.25)  LDD1031  [21]
 LDCM0434  CL44 HEK-293T C264(0.94)  LDD1032  [21]
 LDCM0435  CL45 HEK-293T C264(1.16)  LDD1033  [21]
 LDCM0436  CL46 HEK-293T C264(1.22); C252(1.09); C108(1.03); C133(0.92)  LDD1640  [22]
 LDCM0437  CL47 HEK-293T C264(1.18); C252(1.15); C183(1.15); C108(1.04)  LDD1641  [22]
 LDCM0438  CL48 HEK-293T C264(1.42); C252(1.14); C183(1.04); C108(1.03)  LDD1642  [22]
 LDCM0439  CL49 HEK-293T C264(0.84); C252(1.01); C183(1.26); C108(1.10)  LDD1643  [22]
 LDCM0440  CL5 PaTu 8988t C264(0.91); C363(0.69)  LDD1319  [21]
 LDCM0441  CL50 HEK-293T C264(1.08); C252(1.00); C183(1.01); C108(0.94)  LDD1645  [22]
 LDCM0443  CL52 HEK-293T C252(1.01); C183(1.13); C108(1.17); C276(1.12)  LDD1646  [22]
 LDCM0444  CL53 HEK-293T C264(1.00); C252(0.98); C183(0.98); C108(0.92)  LDD1647  [22]
 LDCM0445  CL54 HEK-293T C264(0.87); C252(1.00); C183(1.82); C108(0.86)  LDD1648  [22]
 LDCM0446  CL55 HEK-293T C252(0.99); C183(0.88); C108(0.99); C276(1.01)  LDD1649  [22]
 LDCM0447  CL56 HEK-293T C264(1.07); C252(1.14); C183(0.89); C108(0.93)  LDD1650  [22]
 LDCM0448  CL57 HEK-293T C252(1.13); C183(0.82); C108(0.80); C276(1.19)  LDD1651  [22]
 LDCM0449  CL58 HEK-293T C264(1.40); C252(1.17); C108(0.93); C133(1.19)  LDD1652  [22]
 LDCM0450  CL59 HEK-293T C264(1.20); C252(1.15); C183(1.20); C108(1.11)  LDD1653  [22]
 LDCM0451  CL6 PaTu 8988t C264(0.98); C363(0.77)  LDD1330  [21]
 LDCM0452  CL60 HEK-293T C264(1.26); C252(1.16); C183(1.06); C108(1.17)  LDD1655  [22]
 LDCM0453  CL61 PaTu 8988t C300(1.07)  LDD1332  [21]
 LDCM0454  CL62 PaTu 8988t C300(1.36)  LDD1333  [21]
 LDCM0455  CL63 PaTu 8988t C300(1.46)  LDD1334  [21]
 LDCM0456  CL64 PaTu 8988t C300(1.18)  LDD1335  [21]
 LDCM0457  CL65 PaTu 8988t C300(1.26)  LDD1336  [21]
 LDCM0458  CL66 PaTu 8988t C300(1.48)  LDD1337  [21]
 LDCM0459  CL67 PaTu 8988t C300(1.41)  LDD1338  [21]
 LDCM0460  CL68 PaTu 8988t C300(1.14)  LDD1339  [21]
 LDCM0461  CL69 PaTu 8988t C300(1.47)  LDD1340  [21]
 LDCM0462  CL7 PaTu 8988t C264(1.15); C363(0.57)  LDD1341  [21]
 LDCM0463  CL70 PaTu 8988t C300(1.46)  LDD1342  [21]
 LDCM0464  CL71 PaTu 8988t C300(0.77)  LDD1343  [21]
 LDCM0465  CL72 PaTu 8988t C300(1.46)  LDD1344  [21]
 LDCM0466  CL73 PaTu 8988t C300(1.86)  LDD1345  [21]
 LDCM0467  CL74 PaTu 8988t C300(1.13)  LDD1346  [21]
 LDCM0469  CL76 HEK-293T C252(1.04); C183(1.21); C108(1.10); C276(1.06)  LDD1672  [22]
 LDCM0470  CL77 HEK-293T C264(0.88); C252(0.96); C183(0.82); C108(0.85)  LDD1673  [22]
 LDCM0471  CL78 HEK-293T C264(0.77); C252(1.04); C183(1.14); C108(0.96)  LDD1674  [22]
 LDCM0472  CL79 HEK-293T C252(1.01); C183(0.97); C108(1.09); C276(0.96)  LDD1675  [22]
 LDCM0473  CL8 PaTu 8988t C264(0.75); C363(0.90)  LDD1352  [21]
 LDCM0474  CL80 HEK-293T C264(1.12); C252(1.04); C183(0.95); C108(0.98)  LDD1677  [22]
 LDCM0475  CL81 HEK-293T C252(1.16); C183(0.97); C108(0.96); C276(1.16)  LDD1678  [22]
 LDCM0476  CL82 HEK-293T C264(1.27); C252(1.08); C108(0.98); C133(1.01)  LDD1679  [22]
 LDCM0477  CL83 HEK-293T C264(1.08); C252(1.15); C183(1.18); C108(1.01)  LDD1680  [22]
 LDCM0478  CL84 HEK-293T C264(1.26); C252(1.07); C183(0.96); C108(1.09)  LDD1681  [22]
 LDCM0479  CL85 HEK-293T C264(0.96); C252(1.03); C183(1.09); C108(1.32)  LDD1682  [22]
 LDCM0480  CL86 HEK-293T C264(1.03); C252(1.06); C183(1.04); C108(0.98)  LDD1683  [22]
 LDCM0481  CL87 HEK-293T C264(0.99); C252(1.08); C183(1.10); C108(1.00)  LDD1684  [22]
 LDCM0482  CL88 HEK-293T C252(1.03); C183(1.04); C108(1.13); C276(0.88)  LDD1685  [22]
 LDCM0483  CL89 HEK-293T C264(1.01); C252(1.03); C183(1.16); C108(1.00)  LDD1686  [22]
 LDCM0484  CL9 PaTu 8988t C264(0.78); C363(0.77)  LDD1363  [21]
 LDCM0485  CL90 HEK-293T C264(0.78); C252(1.02); C183(0.96); C108(0.84)  LDD1688  [22]
 LDCM0486  CL91 PaTu 8988t C264(0.38); C363(1.05)  LDD1365  [21]
 LDCM0487  CL92 PaTu 8988t C264(0.31); C363(0.87)  LDD1366  [21]
 LDCM0488  CL93 PaTu 8988t C264(0.35); C363(0.87)  LDD1367  [21]
 LDCM0489  CL94 PaTu 8988t C264(0.39); C363(0.84)  LDD1368  [21]
 LDCM0490  CL95 PaTu 8988t C264(0.33); C363(0.74)  LDD1369  [21]
 LDCM0491  CL96 PaTu 8988t C264(0.38); C363(0.90)  LDD1370  [21]
 LDCM0492  CL97 PaTu 8988t C264(0.49); C363(0.91)  LDD1371  [21]
 LDCM0493  CL98 PaTu 8988t C264(0.42); C363(1.35)  LDD1372  [21]
 LDCM0494  CL99 PaTu 8988t C264(0.30); C363(1.13)  LDD1373  [21]
 LDCM0495  E2913 HEK-293T C264(1.09); C252(1.02); C183(1.11); C108(1.18)  LDD1698  [22]
 LDCM0625  F8 Ramos C183(0.95)  LDD2187  [23]
 LDCM0572  Fragment10 Ramos C183(1.02)  LDD2189  [23]
 LDCM0573  Fragment11 Ramos C183(0.14)  LDD2190  [23]
 LDCM0574  Fragment12 Ramos C183(0.81)  LDD2191  [23]
 LDCM0575  Fragment13 Ramos C183(0.87)  LDD2192  [23]
 LDCM0576  Fragment14 Ramos C183(0.62)  LDD2193  [23]
 LDCM0579  Fragment20 Ramos C183(0.90)  LDD2194  [23]
 LDCM0580  Fragment21 Ramos C183(1.04)  LDD2195  [23]
 LDCM0582  Fragment23 Ramos C183(2.00)  LDD2196  [23]
 LDCM0578  Fragment27 Ramos C183(1.05)  LDD2197  [23]
 LDCM0586  Fragment28 Ramos C183(0.69)  LDD2198  [23]
 LDCM0588  Fragment30 Ramos C183(1.17)  LDD2199  [23]
 LDCM0589  Fragment31 Ramos C183(1.48)  LDD2200  [23]
 LDCM0590  Fragment32 Ramos C183(1.07)  LDD2201  [23]
 LDCM0468  Fragment33 PaTu 8988t C300(1.40)  LDD1347  [21]
 LDCM0596  Fragment38 Ramos C183(1.22)  LDD2203  [23]
 LDCM0566  Fragment4 Ramos C183(0.74)  LDD2184  [23]
 LDCM0427  Fragment51 HEK-293T C264(1.50)  LDD1025  [21]
 LDCM0610  Fragment52 Ramos C183(0.79)  LDD2204  [23]
 LDCM0614  Fragment56 Ramos C183(0.82)  LDD2205  [23]
 LDCM0569  Fragment7 Ramos C183(0.70)  LDD2186  [23]
 LDCM0571  Fragment9 Ramos C183(1.73)  LDD2188  [23]
 LDCM0107  IAA HeLa C183(0.00); C252(0.00); C98(0.00); H178(0.00)  LDD0221  [15]
 LDCM0022  KB02 HEK-293T C133(0.86); C264(1.10); C252(0.94); C183(0.94)  LDD1492  [22]
 LDCM0023  KB03 Jurkat C363(41.25)  LDD0209  [7]
 LDCM0024  KB05 COLO792 C264(1.07); C98(1.12)  LDD3310  [24]
 LDCM0109  NEM HeLa H146(0.00); H178(0.00)  LDD0223  [15]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C133(0.93); C98(0.81)  LDD2125  [5]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C133(0.93)  LDD2134  [5]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C133(0.98)  LDD2140  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAIAP2L1) . Q9UHR4

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
8 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
9 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
12 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
13 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
14 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
15 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
16 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
17 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
18 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
19 Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.
Mass spectrometry data entry: PXD025652
20 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
21 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
22 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
23 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
24 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840