Details of the Target

General Information of Target

Target ID LDTP15946
Target Name Nascent polypeptide-associated complex subunit alpha-2 (NACA2)
Gene Name NACA2
Gene ID 342538
Synonyms
NACAL; Nascent polypeptide-associated complex subunit alpha-2; Alpha-NAC-like; Hom s 2.01; Nascent polypeptide-associated complex subunit alpha-like; NAC-alpha-like
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSSYLEYVSCSSSGGVGGDVLSLAPKFCRSDARPVALQPAFPLGNGDGAFVSCLPLAAAR
PSPSPPAAPARPSVPPPAAPQYAQCTLEGAYEPGAAPAAAAGGADYGFLGSGPAYDFPGV
LGRAADDGGSHVHYATSAVFSGGGSFLLSGQVDYAAFGEPGPFPACLKASADGHPGAFQT
ASPAPGTYPKSVSPASGLPAAFSTFEWMKVKRNASKKGKLAEYGAASPSSAIRTNFSTKQ
LTELEKEFHFNKYLTRARRIEIANCLHLNDTQVKIWFQNRRMKQKKREREGLLATAIPVA
PLQLPLSGTTPTKFIKNPGSPSQSQEPS
Target Bioclass
Transcription factor
Family
NAC-alpha family
Subcellular location
Cytoplasm
Function
Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites).
Uniprot ID
Q9H009
Ensemble ID
ENST00000521764.3
HGNC ID
HGNC:23290

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
HHS-475
 Probe Info  		Y112(6.85)  LDD0264  [1]
HHS-465
 Probe Info  		N.A.  LDD2240  [2]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BD-F
 Probe Info  		L131(0.00); Q129(0.00)  LDD0024  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0116  HHS-0101 DM93 Y112(6.85)  LDD0264  [1]
 LDCM0117  HHS-0201 DM93 Y112(7.03)  LDD0265  [1]
 LDCM0118  HHS-0301 DM93 Y112(5.50)  LDD0266  [1]
 LDCM0119  HHS-0401 DM93 Y112(13.56)  LDD0267  [1]
 LDCM0120  HHS-0701 DM93 Y112(10.12)  LDD0268  [1]

References

1 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
2 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
3 Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.
Mass spectrometry data entry: PXD025652