Details of the Target

General Information of Target

Target ID LDTP06173
Target Name E3 ubiquitin-protein ligase TRIP12 (TRIP12)
Gene Name TRIP12
Gene ID 9320
Synonyms
KIAA0045; ULF; E3 ubiquitin-protein ligase TRIP12; EC 2.3.2.26; E3 ubiquitin-protein ligase for Arf; ULF; HECT-type E3 ubiquitin transferase TRIP12; Thyroid receptor-interacting protein 12; TR-interacting protein 12; TRIP-12
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSNRPNNNPGGSLRRSQRNTAGAQPQDDSIGGRSCSSSSAVIVPQPEDPDRANTSERQKT
GQVPKKDNSRGVKRSASPDYNRTNSPSSAKKPKALQHTESPSETNKPHSKSKKRHLDQEQ
QLKSAQSPSTSKAHTRKSGATGGSRSQKRKRTESSCVKSGSGSESTGAEERSAKPTKLAS
KSATSAKAGCSTITDSSSAASTSSSSSAVASASSTVPPGARVKQGKDQNKARRSRSASSP
SPRRSSREKEQSKTGGSSKFDWAARFSPKVSLPKTKLSLPGSSKSETSKPGPSGLQAKLA
SLRKSTKKRSESPPAELPSLRRSTRQKTTGSCASTSRRGSGLGKRGAAEARRQEKMADPE
SNQEAVNSSAARTDEAPQGAAGAVGMTTSGESESDDSEMGRLQALLEARGLPPHLFGPLG
PRMSQLFHRTIGSGASSKAQQLLQGLQASDESQQLQAVIEMCQLLVMGNEETLGGFPVKS
VVPALITLLQMEHNFDIMNHACRALTYMMEALPRSSAVVVDAIPVFLEKLQVIQCIDVAE
QALTALEMLSRRHSKAILQAGGLADCLLYLEFFSINAQRNALAIAANCCQSITPDEFHFV
ADSLPLLTQRLTHQDKKSVESTCLCFARLVDNFQHEENLLQQVASKDLLTNVQQLLVVTP
PILSSGMFIMVVRMFSLMCSNCPTLAVQLMKQNIAETLHFLLCGASNGSCQEQIDLVPRS
PQELYELTSLICELMPCLPKEGIFAVDTMLKKGNAQNTDGAIWQWRDDRGLWHPYNRIDS
RIIEQINEDTGTARAIQRKPNPLANSNTSGYSESKKDDARAQLMKEDPELAKSFIKTLFG
VLYEVYSSSAGPAVRHKCLRAILRIIYFADAELLKDVLKNHAVSSHIASMLSSQDLKIVV
GALQMAEILMQKLPDIFSVYFRREGVMHQVKHLAESESLLTSPPKACTNGSGSMGSTTSV
SSGTATAATHAAADLGSPSLQHSRDDSLDLSPQGRLSDVLKRKRLPKRGPRRPKYSPPRD
DDKVDNQAKSPTTTQSPKSSFLASLNPKTWGRLSTQSNSNNIEPARTAGGSGLARAASKD
TISNNREKIKGWIKEQAHKFVERYFSSENMDGSNPALNVLQRLCAATEQLNLQVDGGAEC
LVEIRSIVSESDVSSFEIQHSGFVKQLLLYLTSKSEKDAVSREIRLKRFLHVFFSSPLPG
EEPIGRVEPVGNAPLLALVHKMNNCLSQMEQFPVKVHDFPSGNGTGGSFSLNRGSQALKF
FNTHQLKCQLQRHPDCANVKQWKGGPVKIDPLALVQAIERYLVVRGYGRVREDDEDSDDD
GSDEEIDESLAAQFLNSGNVRHRLQFYIGEHLLPYNMTVYQAVRQFSIQAEDERESTDDE
SNPLGRAGIWTKTHTIWYKPVREDEESNKDCVGGKRGRAQTAPTKTSPRNAKKHDELWHD
GVCPSVSNPLEVYLIPTPPENITFEDPSLDVILLLRVLHAISRYWYYLYDNAMCKEIIPT
SEFINSKLTAKANRQLQDPLVIMTGNIPTWLTELGKTCPFFFPFDTRQMLFYVTAFDRDR
AMQRLLDTNPEINQSDSQDSRVAPRLDRKKRTVNREELLKQAESVMQDLGSSRAMLEIQY
ENEVGTGLGPTLEFYALVSQELQRADLGLWRGEEVTLSNPKGSQEGTKYIQNLQGLFALP
FGRTAKPAHIAKVKMKFRFLGKLMAKAIMDFRLVDLPLGLPFYKWMLRQETSLTSHDLFD
IDPVVARSVYHLEDIVRQKKRLEQDKSQTKESLQYALETLTMNGCSVEDLGLDFTLPGFP
NIELKKGGKDIPVTIHNLEEYLRLVIFWALNEGVSRQFDSFRDGFESVFPLSHLQYFYPE
ELDQLLCGSKADTWDAKTLMECCRPDHGYTHDSRAVKFLFEILSSFDNEQQRLFLQFVTG
SPRLPVGGFRSLNPPLTIVRKTFESTENPDDFLPSVMTCVNYLKLPDYSSIEIMREKLLI
AAREGQQSFHLS
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
UPL family, K-HECT subfamily
Subcellular location
Nucleus, nucleoplasm
Function
E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins. Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes. In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress. In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in different cell compartments, preventing isoform p19ARF/ARF ubiquitination and degradation. Does not mediate ubiquitination of isoform p16-INK4a of CDKN2A. Also catalyzes ubiquitination of NAE1 and SMARCE1, leading to their degradation. Ubiquitination and degradation of target proteins is regulated by interaction with proteins such as MYC, TRADD or SMARCC1, which disrupt the interaction between TRIP12 and target proteins. Mediates ubiquitination of ASXL1: following binding to N(6)-methyladenosine methylated DNA, ASXL1 is ubiquitinated by TRIP12, leading to its degradation and subsequent inactivation of the PR-DUB complex.
TTD ID
T24714
Uniprot ID
Q14669
DrugMap ID
TTG2CRH
Ensemble ID
ENST00000283943.9
HGNC ID
HGNC:12306

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 25 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		9.74  LDD0402  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
STPyne
 Probe Info  		K1001(7.72); K1090(10.00); K616(0.79); K751(5.24)  LDD0277  [3]
Probe 1
 Probe Info  		Y811(15.52)  LDD3495  [4]
BTD
 Probe Info  		C332(1.04)  LDD1700  [5]
AHL-Pu-1
 Probe Info  		C1538(7.54)  LDD0170  [6]
DBIA
 Probe Info  		CAmbiguous(14.33)  LDD0209  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		C1538(0.00); C1867(0.00); C1225(0.00)  LDD0038  [8]
IA-alkyne
 Probe Info  		C1867(0.00); C502(0.00); C1538(0.00)  LDD0036  [8]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [9]
Lodoacetamide azide
 Probe Info  		C1867(0.00); C535(0.00); C1225(0.00); C502(0.00)  LDD0037  [8]
NAIA_4
 Probe Info  		N.A.  LDD2226  [10]
WYneN
 Probe Info  		C332(0.00); C1538(0.00)  LDD0021  [11]
WYneO
 Probe Info  		C156(0.00); C332(0.00)  LDD0022  [11]
ENE
 Probe Info  		N.A.  LDD0006  [11]
IPM
 Probe Info  		N.A.  LDD0005  [11]
TFBX
 Probe Info  		N.A.  LDD0148  [12]
VSF
 Probe Info  		C332(0.00); C35(0.00)  LDD0007  [11]
Phosphinate-6
 Probe Info  		C332(0.00); C156(0.00); C1959(0.00); C35(0.00)  LDD0018  [13]
1c-yne
 Probe Info  		N.A.  LDD0228  [14]
Acrolein
 Probe Info  		H928(0.00); H115(0.00)  LDD0217  [15]
Methacrolein
 Probe Info  		N.A.  LDD0218  [15]
W1
 Probe Info  		C332(0.00); C1276(0.00); C1225(0.00)  LDD0236  [16]
AOyne
 Probe Info  		8.10  LDD0443  [17]
NAIA_5
 Probe Info  		C947(0.00); C1538(0.00)  LDD2223  [10]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		20.00  LDD0475  [18]
BD-F
 Probe Info  		Q531(0.00); I536(0.00); C535(0.00); Q541(0.00)  LDD0024  [19]
LD-F
 Probe Info  		Q534(0.00); D537(0.00); I536(0.00); C535(0.00)  LDD0015  [19]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C332(0.80)  LDD2117  [5]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C332(0.81)  LDD2152  [5]
 LDCM0025  4SU-RNA DM93 C1538(7.54)  LDD0170  [6]
 LDCM0026  4SU-RNA+native RNA DM93 C947(12.74); C1538(3.51)  LDD0171  [6]
 LDCM0214  AC1 HEK-293T C1276(0.95); C1538(0.92); C1959(1.04); C502(0.98)  LDD1507  [20]
 LDCM0215  AC10 HEK-293T C1276(0.94); C156(1.00); C1538(1.07); C1959(1.02)  LDD1508  [20]
 LDCM0226  AC11 HEK-293T C1276(1.05); C156(1.08); C1538(0.96); C1959(1.16)  LDD1509  [20]
 LDCM0237  AC12 HEK-293T C1276(1.00); C156(1.10); C35(1.28); C1538(1.16)  LDD1510  [20]
 LDCM0259  AC14 HEK-293T C1276(0.98); C156(1.12); C1538(1.11); C1959(0.98)  LDD1512  [20]
 LDCM0270  AC15 HEK-293T C1276(0.98); C156(1.20); C1538(0.96); C1959(0.86)  LDD1513  [20]
 LDCM0276  AC17 HEK-293T C1276(0.92); C1538(0.87); C1959(1.09); C502(1.01)  LDD1515  [20]
 LDCM0277  AC18 HEK-293T C1276(0.95); C156(1.01); C1538(0.96); C1959(1.00)  LDD1516  [20]
 LDCM0278  AC19 HEK-293T C1276(0.89); C156(1.69); C1538(0.86); C1959(1.10)  LDD1517  [20]
 LDCM0279  AC2 HEK-293T C1276(1.03); C156(0.96); C1538(1.06); C1959(1.09)  LDD1518  [20]
 LDCM0280  AC20 HEK-293T C1276(0.99); C156(1.08); C35(1.16); C1538(1.04)  LDD1519  [20]
 LDCM0281  AC21 HEK-293T C1276(0.94); C156(0.96); C1538(1.16); C1959(0.93)  LDD1520  [20]
 LDCM0282  AC22 HEK-293T C1276(0.92); C156(1.04); C1538(1.15); C1959(0.97)  LDD1521  [20]
 LDCM0283  AC23 HEK-293T C1276(1.02); C156(1.09); C1538(1.03); C1959(0.85)  LDD1522  [20]
 LDCM0284  AC24 HEK-293T C1276(1.08); C1538(1.03); C1959(1.07); C502(1.02)  LDD1523  [20]
 LDCM0285  AC25 HEK-293T C1276(0.96); C1538(1.03); C1959(1.12); C502(0.93)  LDD1524  [20]
 LDCM0286  AC26 HEK-293T C1276(0.99); C156(1.04); C1538(1.06); C1959(1.06)  LDD1525  [20]
 LDCM0287  AC27 HEK-293T C1276(0.97); C156(1.06); C1538(0.95); C1959(1.07)  LDD1526  [20]
 LDCM0288  AC28 HEK-293T C1276(0.96); C156(0.96); C35(1.24); C1538(1.02)  LDD1527  [20]
 LDCM0289  AC29 HEK-293T C1276(1.03); C156(1.01); C1538(1.07); C1959(0.95)  LDD1528  [20]
 LDCM0290  AC3 HEK-293T C1276(1.04); C156(1.06); C1538(0.94); C1959(1.10)  LDD1529  [20]
 LDCM0291  AC30 HEK-293T C1276(1.01); C156(0.99); C1538(0.99); C1959(1.02)  LDD1530  [20]
 LDCM0292  AC31 HEK-293T C1276(1.02); C156(0.98); C1538(1.02); C1959(0.95)  LDD1531  [20]
 LDCM0293  AC32 HEK-293T C1276(0.99); C1538(0.94); C1959(1.21); C502(1.06)  LDD1532  [20]
 LDCM0294  AC33 HEK-293T C1276(0.95); C1538(0.92); C1959(1.07); C502(0.91)  LDD1533  [20]
 LDCM0295  AC34 HEK-293T C1276(0.95); C156(1.02); C1538(1.09); C1959(1.06)  LDD1534  [20]
 LDCM0296  AC35 HEK-293T C1276(0.90); C156(1.13); C1538(0.93); C1959(1.08)  LDD1535  [20]
 LDCM0297  AC36 HEK-293T C1276(1.03); C156(1.05); C35(1.13); C1538(1.03)  LDD1536  [20]
 LDCM0298  AC37 HEK-293T C1276(1.06); C156(1.09); C1538(1.17); C1959(0.92)  LDD1537  [20]
 LDCM0299  AC38 HEK-293T C1276(0.94); C156(1.03); C1538(1.02); C1959(1.03)  LDD1538  [20]
 LDCM0300  AC39 HEK-293T C1276(0.97); C156(1.10); C1538(0.97); C1959(0.95)  LDD1539  [20]
 LDCM0301  AC4 HEK-293T C1276(0.99); C156(0.92); C35(1.03); C1538(1.10)  LDD1540  [20]
 LDCM0302  AC40 HEK-293T C1276(1.00); C1538(0.97); C1959(1.02); C502(0.92)  LDD1541  [20]
 LDCM0303  AC41 HEK-293T C1276(0.96); C1538(0.95); C1959(1.16); C502(0.90)  LDD1542  [20]
 LDCM0304  AC42 HEK-293T C1276(0.93); C156(1.07); C1538(1.02); C1959(1.06)  LDD1543  [20]
 LDCM0305  AC43 HEK-293T C1276(0.98); C156(1.07); C1538(0.94); C1959(1.15)  LDD1544  [20]
 LDCM0306  AC44 HEK-293T C1276(0.99); C156(1.09); C35(1.13); C1538(1.16)  LDD1545  [20]
 LDCM0307  AC45 HEK-293T C1276(0.94); C156(0.97); C1538(1.03); C1959(1.07)  LDD1546  [20]
 LDCM0308  AC46 HEK-293T C1276(1.03); C156(1.07); C1538(1.19); C1959(1.05)  LDD1547  [20]
 LDCM0309  AC47 HEK-293T C1276(1.03); C156(1.09); C1538(0.98); C1959(0.89)  LDD1548  [20]
 LDCM0310  AC48 HEK-293T C1276(1.13); C1538(1.04); C1959(1.27); C502(1.08)  LDD1549  [20]
 LDCM0311  AC49 HEK-293T C1276(0.93); C1538(0.91); C1959(0.97); C502(0.88)  LDD1550  [20]
 LDCM0312  AC5 HEK-293T C1276(0.92); C156(0.91); C1538(1.00); C1959(1.00)  LDD1551  [20]
 LDCM0313  AC50 HEK-293T C1276(1.02); C156(1.01); C1538(1.15); C1959(0.97)  LDD1552  [20]
 LDCM0314  AC51 HEK-293T C1276(1.11); C156(1.03); C1538(0.95); C1959(1.16)  LDD1553  [20]
 LDCM0315  AC52 HEK-293T C1276(1.05); C156(0.99); C35(0.93); C1538(1.08)  LDD1554  [20]
 LDCM0316  AC53 HEK-293T C1276(1.05); C156(0.97); C1538(1.01); C1959(0.98)  LDD1555  [20]
 LDCM0317  AC54 HEK-293T C1276(0.93); C156(1.04); C1538(1.00); C1959(1.00)  LDD1556  [20]
 LDCM0318  AC55 HEK-293T C1276(0.98); C156(1.22); C1538(0.99); C1959(0.94)  LDD1557  [20]
 LDCM0319  AC56 HEK-293T C1276(1.03); C1538(1.08); C1959(1.20); C502(1.01)  LDD1558  [20]
 LDCM0320  AC57 HEK-293T C1276(0.91); C1538(1.00); C1959(1.04); C502(1.01)  LDD1559  [20]
 LDCM0321  AC58 HEK-293T C1276(0.97); C156(0.96); C1538(1.19); C1959(1.04)  LDD1560  [20]
 LDCM0322  AC59 HEK-293T C1276(1.02); C156(1.03); C1538(0.95); C1959(1.08)  LDD1561  [20]
 LDCM0323  AC6 HEK-293T C1276(0.96); C156(0.99); C1538(0.98); C1959(1.05)  LDD1562  [20]
 LDCM0324  AC60 HEK-293T C1276(0.99); C156(1.04); C35(0.88); C1538(1.07)  LDD1563  [20]
 LDCM0325  AC61 HEK-293T C1276(0.92); C156(0.93); C1538(1.08); C1959(0.98)  LDD1564  [20]
 LDCM0326  AC62 HEK-293T C1276(0.93); C156(1.04); C1538(1.08); C1959(1.01)  LDD1565  [20]
 LDCM0327  AC63 HEK-293T C1276(0.97); C156(0.98); C1538(1.10); C1959(0.92)  LDD1566  [20]
 LDCM0328  AC64 HEK-293T C1276(1.02); C1538(1.04); C1959(0.86); C502(1.14)  LDD1567  [20]
 LDCM0334  AC7 HEK-293T C1276(1.02); C156(1.06); C1538(0.94); C1959(1.04)  LDD1568  [20]
 LDCM0345  AC8 HEK-293T C1276(1.02); C1538(0.99); C1959(1.02); C502(0.98)  LDD1569  [20]
 LDCM0248  AKOS034007472 HEK-293T C1276(1.05); C156(0.97); C1538(1.25); C1959(1.00)  LDD1511  [20]
 LDCM0356  AKOS034007680 HEK-293T C1276(0.94); C1538(1.00); C1959(1.04); C502(0.91)  LDD1570  [20]
 LDCM0275  AKOS034007705 HEK-293T C1276(1.01); C1538(0.91); C1959(1.31); C502(1.10)  LDD1514  [20]
 LDCM0630  CCW28-3 231MFP C535(1.12)  LDD2214  [21]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [15]
 LDCM0632  CL-Sc Hep-G2 C947(20.00); C1411(20.00)  LDD2227  [10]
 LDCM0367  CL1 HEK-293T C1276(1.02); C156(0.97); C1538(1.08); C1959(1.06)  LDD1571  [20]
 LDCM0368  CL10 HEK-293T C1276(0.87); C156(1.10); C1538(1.07); C1959(1.19)  LDD1572  [20]
 LDCM0369  CL100 HEK-293T C1276(1.00); C156(1.06); C1538(1.11); C1959(0.98)  LDD1573  [20]
 LDCM0370  CL101 HEK-293T C1276(0.98); C156(1.02); C1538(1.12); C1959(1.09)  LDD1574  [20]
 LDCM0371  CL102 HEK-293T C1276(0.95); C156(1.15); C1538(1.06); C1959(1.23)  LDD1575  [20]
 LDCM0372  CL103 HEK-293T C1276(1.00); C156(1.12); C1538(1.11); C1959(0.89)  LDD1576  [20]
 LDCM0373  CL104 HEK-293T C1276(1.01); C156(1.09); C1538(1.17); C1959(0.89)  LDD1577  [20]
 LDCM0374  CL105 HEK-293T C1276(0.93); C156(1.02); C1538(1.04); C1959(1.11)  LDD1578  [20]
 LDCM0375  CL106 HEK-293T C1276(0.97); C156(1.04); C1538(1.18); C1959(1.05)  LDD1579  [20]
 LDCM0376  CL107 HEK-293T C1276(0.97); C156(1.05); C1538(1.00); C1959(0.90)  LDD1580  [20]
 LDCM0377  CL108 HEK-293T C1276(0.98); C156(1.04); C1538(1.18); C1959(1.01)  LDD1581  [20]
 LDCM0378  CL109 HEK-293T C1276(0.93); C156(0.99); C1538(1.12); C1959(1.03)  LDD1582  [20]
 LDCM0379  CL11 HEK-293T C1276(0.95); C156(1.03); C1538(0.91); C1959(0.99)  LDD1583  [20]
 LDCM0380  CL110 HEK-293T C1276(0.95); C156(1.09); C1538(0.78); C1959(1.20)  LDD1584  [20]
 LDCM0381  CL111 HEK-293T C1276(1.00); C156(0.99); C1538(1.05); C1959(1.04)  LDD1585  [20]
 LDCM0382  CL112 HEK-293T C1276(0.99); C156(1.09); C1538(1.09); C1959(1.06)  LDD1586  [20]
 LDCM0383  CL113 HEK-293T C1276(0.99); C156(1.04); C1538(0.94); C1959(0.90)  LDD1587  [20]
 LDCM0384  CL114 HEK-293T C1276(0.92); C156(0.97); C1538(0.99); C1959(1.16)  LDD1588  [20]
 LDCM0385  CL115 HEK-293T C1276(1.04); C156(1.10); C1538(0.96); C1959(1.00)  LDD1589  [20]
 LDCM0386  CL116 HEK-293T C1276(0.98); C156(1.03); C1538(1.08); C1959(0.92)  LDD1590  [20]
 LDCM0387  CL117 HEK-293T C1276(1.03); C156(1.07); C1538(1.07); C1959(1.03)  LDD1591  [20]
 LDCM0388  CL118 HEK-293T C1276(0.99); C156(1.21); C1538(1.01); C1959(1.00)  LDD1592  [20]
 LDCM0389  CL119 HEK-293T C1276(1.08); C156(1.10); C1538(1.03); C1959(1.07)  LDD1593  [20]
 LDCM0390  CL12 HEK-293T C1276(1.03); C1538(1.06); C1959(1.20); C502(1.07)  LDD1594  [20]
 LDCM0391  CL120 HEK-293T C1276(0.99); C156(1.10); C1538(1.11); C1959(1.12)  LDD1595  [20]
 LDCM0392  CL121 HEK-293T C1276(1.01); C156(0.99); C1538(1.06); C1959(0.98)  LDD1596  [20]
 LDCM0393  CL122 HEK-293T C1276(0.97); C156(1.19); C1538(1.00); C1959(0.97)  LDD1597  [20]
 LDCM0394  CL123 HEK-293T C1276(0.99); C156(1.01); C1538(1.13); C1959(0.95)  LDD1598  [20]
 LDCM0395  CL124 HEK-293T C1276(0.92); C156(1.09); C1538(1.17); C1959(1.01)  LDD1599  [20]
 LDCM0396  CL125 HEK-293T C1276(0.97); C156(0.95); C1538(1.11); C1959(1.12)  LDD1600  [20]
 LDCM0397  CL126 HEK-293T C1276(0.95); C156(1.00); C1538(1.14); C1959(1.08)  LDD1601  [20]
 LDCM0398  CL127 HEK-293T C1276(1.00); C156(1.02); C1538(1.10); C1959(0.92)  LDD1602  [20]
 LDCM0399  CL128 HEK-293T C1276(0.95); C156(0.99); C1538(1.22); C1959(1.07)  LDD1603  [20]
 LDCM0400  CL13 HEK-293T C1276(1.03); C156(1.15); C1538(0.96); C1959(1.24)  LDD1604  [20]
 LDCM0401  CL14 HEK-293T C1276(0.96); C156(1.14); C1538(1.06); C1959(1.15)  LDD1605  [20]
 LDCM0402  CL15 HEK-293T C1276(0.98); C156(1.10); C1538(0.99); C1959(0.86)  LDD1606  [20]
 LDCM0403  CL16 HEK-293T C1276(1.01); C156(1.01); C1538(1.08); C1959(0.96)  LDD1607  [20]
 LDCM0404  CL17 HEK-293T C1276(0.85); C1538(1.01); C1959(1.13); C502(0.82)  LDD1608  [20]
 LDCM0405  CL18 HEK-293T C1276(1.01); C156(0.99); C1538(0.98); C1959(1.00)  LDD1609  [20]
 LDCM0406  CL19 HEK-293T C1276(0.96); C156(1.12); C1538(0.90); C1959(1.20)  LDD1610  [20]
 LDCM0407  CL2 HEK-293T C1276(1.01); C156(1.11); C1538(0.95); C1959(1.15)  LDD1611  [20]
 LDCM0408  CL20 HEK-293T C1276(1.00); C156(1.15); C35(2.46); C1538(0.90)  LDD1612  [20]
 LDCM0409  CL21 HEK-293T C1276(0.89); C156(0.91); C1538(1.22); C1959(1.04)  LDD1613  [20]
 LDCM0410  CL22 HEK-293T C1276(0.94); C156(1.16); C1538(1.00); C1959(1.02)  LDD1614  [20]
 LDCM0411  CL23 HEK-293T C1276(1.01); C156(1.06); C1538(0.93); C1959(0.93)  LDD1615  [20]
 LDCM0412  CL24 HEK-293T C1276(1.03); C1538(1.05); C1959(1.06); C502(1.17)  LDD1616  [20]
 LDCM0413  CL25 HEK-293T C1276(0.95); C156(0.91); C1538(1.01); C1959(0.94)  LDD1617  [20]
 LDCM0414  CL26 HEK-293T C1276(0.99); C156(1.31); C1538(0.91); C1959(1.02)  LDD1618  [20]
 LDCM0415  CL27 HEK-293T C1276(1.01); C156(1.06); C1538(0.99); C1959(0.94)  LDD1619  [20]
 LDCM0416  CL28 HEK-293T C1276(1.03); C156(1.06); C1538(1.01); C1959(1.04)  LDD1620  [20]
 LDCM0417  CL29 HEK-293T C1276(0.94); C1538(0.98); C1959(1.09); C502(1.00)  LDD1621  [20]
 LDCM0418  CL3 HEK-293T C1276(1.17); C156(1.09); C1538(0.88); C1959(0.95)  LDD1622  [20]
 LDCM0419  CL30 HEK-293T C1276(1.01); C156(1.00); C1538(1.02); C1959(1.04)  LDD1623  [20]
 LDCM0420  CL31 HEK-293T C1276(1.01); C156(1.06); C1538(0.84); C1959(1.12)  LDD1624  [20]
 LDCM0421  CL32 HEK-293T C1276(1.02); C156(0.98); C35(1.34); C1538(0.99)  LDD1625  [20]
 LDCM0422  CL33 HEK-293T C1276(0.92); C156(0.98); C1538(1.18); C1959(0.84)  LDD1626  [20]
 LDCM0423  CL34 HEK-293T C1276(1.02); C156(1.01); C1538(1.04); C1959(0.97)  LDD1627  [20]
 LDCM0424  CL35 HEK-293T C1276(0.96); C156(1.07); C1538(0.93); C1959(0.89)  LDD1628  [20]
 LDCM0425  CL36 HEK-293T C1276(1.05); C1538(0.92); C1959(0.98); C502(1.01)  LDD1629  [20]
 LDCM0426  CL37 HEK-293T C1276(1.05); C156(0.94); C1538(1.13); C1959(1.15)  LDD1630  [20]
 LDCM0428  CL39 HEK-293T C1276(0.96); C156(0.97); C1538(1.13); C1959(0.88)  LDD1632  [20]
 LDCM0429  CL4 HEK-293T C1276(1.00); C156(1.05); C1538(1.11); C1959(0.90)  LDD1633  [20]
 LDCM0430  CL40 HEK-293T C1276(1.01); C156(1.11); C1538(1.02); C1959(1.11)  LDD1634  [20]
 LDCM0431  CL41 HEK-293T C1276(0.97); C1538(0.96); C1959(0.97); C502(0.95)  LDD1635  [20]
 LDCM0432  CL42 HEK-293T C1276(1.04); C156(0.97); C1538(1.13); C1959(1.00)  LDD1636  [20]
 LDCM0433  CL43 HEK-293T C1276(0.96); C156(1.11); C1538(0.91); C1959(1.08)  LDD1637  [20]
 LDCM0434  CL44 HEK-293T C1276(0.96); C156(1.17); C35(1.16); C1538(0.94)  LDD1638  [20]
 LDCM0435  CL45 HEK-293T C1276(0.91); C156(1.00); C1538(0.98); C1959(1.13)  LDD1639  [20]
 LDCM0436  CL46 HEK-293T C1276(0.93); C156(1.03); C1538(1.05); C1959(1.01)  LDD1640  [20]
 LDCM0437  CL47 HEK-293T C1276(0.99); C156(1.12); C1538(1.04); C1959(0.96)  LDD1641  [20]
 LDCM0438  CL48 HEK-293T C1276(1.01); C1538(0.97); C1959(0.90); C502(1.09)  LDD1642  [20]
 LDCM0439  CL49 HEK-293T C1276(1.04); C156(0.97); C1538(1.05); C1959(0.89)  LDD1643  [20]
 LDCM0440  CL5 HEK-293T C1276(1.01); C1538(0.98); C1959(1.20); C502(0.93)  LDD1644  [20]
 LDCM0441  CL50 HEK-293T C1276(0.98); C156(1.01); C1538(1.10); C1959(1.20)  LDD1645  [20]
 LDCM0443  CL52 HEK-293T C1276(1.03); C156(1.05); C1538(1.07); C1959(1.01)  LDD1646  [20]
 LDCM0444  CL53 HEK-293T C1276(0.91); C1538(1.03); C1959(1.01); C502(0.95)  LDD1647  [20]
 LDCM0445  CL54 HEK-293T C1276(0.88); C156(1.10); C1538(1.18); C1959(1.04)  LDD1648  [20]
 LDCM0446  CL55 HEK-293T C1276(0.98); C156(1.12); C1538(0.93); C1959(1.21)  LDD1649  [20]
 LDCM0447  CL56 HEK-293T C1276(1.04); C156(0.94); C35(1.18); C1538(0.98)  LDD1650  [20]
 LDCM0448  CL57 HEK-293T C1276(0.91); C156(1.20); C1538(1.13); C1959(1.02)  LDD1651  [20]
 LDCM0449  CL58 HEK-293T C1276(0.99); C156(1.04); C1538(1.04); C1959(0.98)  LDD1652  [20]
 LDCM0450  CL59 HEK-293T C1276(0.95); C156(1.06); C1538(0.91); C1959(0.93)  LDD1653  [20]
 LDCM0451  CL6 HEK-293T C1276(0.90); C156(0.97); C1538(0.92); C1959(1.24)  LDD1654  [20]
 LDCM0452  CL60 HEK-293T C1276(1.05); C1538(1.10); C1959(1.39); C502(1.01)  LDD1655  [20]
 LDCM0453  CL61 HEK-293T C1276(1.02); C156(0.96); C1538(1.02); C1959(0.92)  LDD1656  [20]
 LDCM0454  CL62 HEK-293T C1276(0.98); C156(1.07); C1538(1.04); C1959(1.09)  LDD1657  [20]
 LDCM0455  CL63 HEK-293T C1276(1.08); C156(1.08); C1538(1.10); C1959(1.09)  LDD1658  [20]
 LDCM0456  CL64 HEK-293T C1276(0.98); C156(1.09); C1538(1.08); C1959(1.02)  LDD1659  [20]
 LDCM0457  CL65 HEK-293T C1276(0.99); C1538(0.95); C1959(1.08); C502(0.95)  LDD1660  [20]
 LDCM0458  CL66 HEK-293T C1276(0.97); C156(1.00); C1538(1.04); C1959(1.12)  LDD1661  [20]
 LDCM0459  CL67 HEK-293T C1276(0.95); C156(1.10); C1538(0.88); C1959(1.08)  LDD1662  [20]
 LDCM0460  CL68 HEK-293T C1276(1.07); C156(0.95); C35(0.99); C1538(1.06)  LDD1663  [20]
 LDCM0461  CL69 HEK-293T C1276(0.92); C156(0.95); C1538(1.15); C1959(1.01)  LDD1664  [20]
 LDCM0462  CL7 HEK-293T C1276(1.03); C156(1.04); C1538(0.90); C1959(1.17)  LDD1665  [20]
 LDCM0463  CL70 HEK-293T C1276(0.99); C156(1.04); C1538(1.18); C1959(1.04)  LDD1666  [20]
 LDCM0464  CL71 HEK-293T C1276(1.03); C156(1.29); C1538(1.06); C1959(0.98)  LDD1667  [20]
 LDCM0465  CL72 HEK-293T C1276(1.02); C1538(0.97); C1959(0.92); C502(1.12)  LDD1668  [20]
 LDCM0466  CL73 HEK-293T C1276(0.98); C156(0.96); C1538(1.18); C1959(0.94)  LDD1669  [20]
 LDCM0467  CL74 HEK-293T C1276(0.99); C156(1.11); C1538(0.97); C1959(0.98)  LDD1670  [20]
 LDCM0469  CL76 HEK-293T C1276(0.92); C156(1.03); C1538(1.02); C1959(0.94)  LDD1672  [20]
 LDCM0470  CL77 HEK-293T C1276(0.88); C1538(0.89); C1959(1.11); C502(0.89)  LDD1673  [20]
 LDCM0471  CL78 HEK-293T C1276(1.04); C156(0.99); C1538(1.00); C1959(0.91)  LDD1674  [20]
 LDCM0472  CL79 HEK-293T C1276(1.06); C156(1.17); C1538(0.95); C1959(1.13)  LDD1675  [20]
 LDCM0473  CL8 HEK-293T C1276(0.86); C156(0.90); C35(0.75); C1538(1.09)  LDD1676  [20]
 LDCM0474  CL80 HEK-293T C1276(1.12); C156(1.07); C35(0.97); C1538(0.98)  LDD1677  [20]
 LDCM0475  CL81 HEK-293T C1276(0.96); C156(0.99); C1538(1.19); C1959(0.91)  LDD1678  [20]
 LDCM0476  CL82 HEK-293T C1276(0.96); C156(1.04); C1538(0.98); C1959(0.99)  LDD1679  [20]
 LDCM0477  CL83 HEK-293T C1276(1.00); C156(1.22); C1538(0.95); C1959(0.88)  LDD1680  [20]
 LDCM0478  CL84 HEK-293T C1276(1.06); C1538(1.19); C1959(0.91); C502(1.15)  LDD1681  [20]
 LDCM0479  CL85 HEK-293T C1276(1.05); C156(0.97); C1538(1.09); C1959(1.14)  LDD1682  [20]
 LDCM0480  CL86 HEK-293T C1276(0.97); C156(0.91); C1538(0.99); C1959(1.13)  LDD1683  [20]
 LDCM0481  CL87 HEK-293T C1276(1.11); C156(1.04); C1538(1.10); C1959(1.11)  LDD1684  [20]
 LDCM0482  CL88 HEK-293T C1276(1.01); C156(0.98); C1538(1.12); C1959(0.95)  LDD1685  [20]
 LDCM0483  CL89 HEK-293T C1276(0.97); C1538(0.98); C1959(1.08); C502(0.92)  LDD1686  [20]
 LDCM0484  CL9 HEK-293T C1276(0.93); C156(0.95); C1538(1.12); C1959(0.95)  LDD1687  [20]
 LDCM0485  CL90 HEK-293T C1276(0.91); C156(1.06); C1538(1.10); C1959(1.06)  LDD1688  [20]
 LDCM0486  CL91 HEK-293T C1276(1.13); C156(1.06); C1538(0.93); C1959(1.17)  LDD1689  [20]
 LDCM0487  CL92 HEK-293T C1276(0.98); C156(1.10); C35(1.31); C1538(1.13)  LDD1690  [20]
 LDCM0488  CL93 HEK-293T C1276(0.92); C156(0.95); C1538(1.08); C1959(0.99)  LDD1691  [20]
 LDCM0489  CL94 HEK-293T C1276(0.92); C156(1.04); C1538(1.06); C1959(1.03)  LDD1692  [20]
 LDCM0490  CL95 HEK-293T C1276(0.90); C156(1.08); C1538(1.11); C1959(1.08)  LDD1693  [20]
 LDCM0491  CL96 HEK-293T C1276(0.93); C1538(1.22); C1959(1.28); C502(0.94)  LDD1694  [20]
 LDCM0492  CL97 HEK-293T C1276(1.04); C156(0.95); C1538(1.14); C1959(1.00)  LDD1695  [20]
 LDCM0493  CL98 HEK-293T C1276(0.99); C156(1.06); C1538(1.09); C1959(1.07)  LDD1696  [20]
 LDCM0494  CL99 HEK-293T C1276(0.91); C156(1.09); C1538(1.09); C1959(1.06)  LDD1697  [20]
 LDCM0495  E2913 HEK-293T C1276(0.95); C156(1.17); C1538(0.96); C1959(1.40)  LDD1698  [20]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C1538(4.20); C332(1.16); C1276(1.02)  LDD1702  [5]
 LDCM0625  F8 Ramos C35(1.61)  LDD2187  [22]
 LDCM0572  Fragment10 Ramos C35(0.81)  LDD2189  [22]
 LDCM0574  Fragment12 Ramos C35(0.36)  LDD2191  [22]
 LDCM0576  Fragment14 Ramos C35(1.05)  LDD2193  [22]
 LDCM0579  Fragment20 Ramos C35(0.28)  LDD2194  [22]
 LDCM0580  Fragment21 Ramos C35(0.52)  LDD2195  [22]
 LDCM0582  Fragment23 Ramos C35(0.50)  LDD2196  [22]
 LDCM0588  Fragment30 Ramos C35(0.63)  LDD2199  [22]
 LDCM0590  Fragment32 Ramos C35(0.85)  LDD2201  [22]
 LDCM0468  Fragment33 HEK-293T C1276(1.07); C156(1.04); C1538(1.08); C1959(1.04)  LDD1671  [20]
 LDCM0596  Fragment38 Ramos C35(0.30)  LDD2203  [22]
 LDCM0566  Fragment4 Ramos C35(0.78)  LDD2184  [22]
 LDCM0427  Fragment51 HEK-293T C1276(0.96); C156(1.12); C1538(0.97); C1959(0.96)  LDD1631  [20]
 LDCM0569  Fragment7 Ramos C35(0.86)  LDD2186  [22]
 LDCM0571  Fragment9 Ramos C35(0.54)  LDD2188  [22]
 LDCM0022  KB02 HEK-293T C332(0.97); C1276(0.98); C156(0.88); C1538(0.78)  LDD1492  [20]
 LDCM0023  KB03 Jurkat CAmbiguous(14.33)  LDD0209  [7]
 LDCM0024  KB05 COLO792 C1459(3.64); C1586(7.16)  LDD3310  [23]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C332(1.81)  LDD2102  [5]
 LDCM0109  NEM HeLa N.A.  LDD0223  [15]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C332(1.42)  LDD2090  [5]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C332(0.97)  LDD2093  [5]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C332(1.04)  LDD2098  [5]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C332(0.51)  LDD2099  [5]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C332(0.89)  LDD2100  [5]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C332(0.51)  LDD2101  [5]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C332(0.79)  LDD2107  [5]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C332(0.99)  LDD2108  [5]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C332(0.65)  LDD2109  [5]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C332(0.92)  LDD2111  [5]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C332(1.52)  LDD2118  [5]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C332(1.16)  LDD2119  [5]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C332(0.44)  LDD2123  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C332(0.62)  LDD2125  [5]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C332(1.22)  LDD2126  [5]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C332(0.69)  LDD2127  [5]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C332(0.56)  LDD2134  [5]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C332(0.87)  LDD2136  [5]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C332(0.82)  LDD2137  [5]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C332(1.04)  LDD1700  [5]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C332(0.61)  LDD2140  [5]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C332(0.64)  LDD2141  [5]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C332(2.50)  LDD2153  [5]
 LDCM0131  RA190 MM1.R C35(1.08)  LDD0304  [24]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ubiquitin carboxyl-terminal hydrolase 7 (USP7) Peptidase C19 family Q93009
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Myc proto-oncogene protein (MYC) . P01106
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Melatonin receptor type 1B (MTNR1B) G-protein coupled receptor 1 family P49286
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tumor suppressor ARF (CDKN2A) . Q8N726

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
14 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
15 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
16 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
17 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
18 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
19 Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.
Mass spectrometry data entry: PXD025652
20 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
21 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
22 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
23 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
24 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.