Details of the Target

General Information of Target

Target ID LDTP10567
Target Name Regulator of microtubule dynamics protein 2 (RMDN2)
Gene Name RMDN2
Gene ID 151393
Synonyms
FAM82A; FAM82A1; Regulator of microtubule dynamics protein 2; RMD-2; hRMD-2; Protein FAM82A1
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MGNEASYPAEMCSHFDNDEIKRLGRRFKKLDLDKSGSLSVEEFMSLPELRHNPLVRRVID
VFDTDGDGEVDFKEFILGTSQFSVKGDEEQKLRFAFSIYDMDKDGYISNGELFQVLKMMV
GNNLTDWQLQQLVDKTIIILDKDGDGKISFEEFSAVVRDLEIHKKLVLIV
Target Bioclass
Other
Family
RMDN family
Subcellular location
Membrane
Uniprot ID
Q96LZ7
Ensemble ID
ENST00000354545.8
HGNC ID
HGNC:26567

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HEC1 SNV: p.E104G .
NCIH1155 SNV: p.A138T .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C491(2.44)  LDD3314  [1]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C055
 Probe Info  		14.83  LDD1752  [2]
C056
 Probe Info  		30.06  LDD1753  [2]
A-DA
 Probe Info  		2.06  LDD0142  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C381(0.94)  LDD1508  [4]
 LDCM0226  AC11 HEK-293T C353(0.98)  LDD1509  [4]
 LDCM0237  AC12 HEK-293T C381(0.89)  LDD1510  [4]
 LDCM0259  AC14 HEK-293T C381(0.77)  LDD1512  [4]
 LDCM0270  AC15 HEK-293T C381(0.91)  LDD1513  [4]
 LDCM0277  AC18 HEK-293T C381(1.09)  LDD1516  [4]
 LDCM0278  AC19 HEK-293T C353(1.00)  LDD1517  [4]
 LDCM0279  AC2 HEK-293T C381(0.94)  LDD1518  [4]
 LDCM0280  AC20 HEK-293T C381(1.11)  LDD1519  [4]
 LDCM0282  AC22 HEK-293T C381(0.93)  LDD1521  [4]
 LDCM0283  AC23 HEK-293T C381(0.72)  LDD1522  [4]
 LDCM0284  AC24 HEK-293T C381(1.03)  LDD1523  [4]
 LDCM0286  AC26 HEK-293T C381(1.07)  LDD1525  [4]
 LDCM0287  AC27 HEK-293T C353(1.27)  LDD1526  [4]
 LDCM0288  AC28 HEK-293T C381(0.90)  LDD1527  [4]
 LDCM0290  AC3 HEK-293T C353(1.24)  LDD1529  [4]
 LDCM0291  AC30 HEK-293T C381(0.84)  LDD1530  [4]
 LDCM0292  AC31 HEK-293T C381(1.04)  LDD1531  [4]
 LDCM0293  AC32 HEK-293T C381(1.24)  LDD1532  [4]
 LDCM0295  AC34 HEK-293T C381(1.01)  LDD1534  [4]
 LDCM0296  AC35 HEK-293T C353(0.95)  LDD1535  [4]
 LDCM0297  AC36 HEK-293T C381(0.97)  LDD1536  [4]
 LDCM0299  AC38 HEK-293T C381(1.26)  LDD1538  [4]
 LDCM0300  AC39 HEK-293T C381(1.14)  LDD1539  [4]
 LDCM0301  AC4 HEK-293T C381(1.08)  LDD1540  [4]
 LDCM0302  AC40 HEK-293T C381(1.15)  LDD1541  [4]
 LDCM0304  AC42 HEK-293T C381(1.29)  LDD1543  [4]
 LDCM0305  AC43 HEK-293T C353(1.03)  LDD1544  [4]
 LDCM0306  AC44 HEK-293T C381(1.10)  LDD1545  [4]
 LDCM0308  AC46 HEK-293T C381(0.99)  LDD1547  [4]
 LDCM0309  AC47 HEK-293T C381(1.20)  LDD1548  [4]
 LDCM0310  AC48 HEK-293T C381(1.02)  LDD1549  [4]
 LDCM0313  AC50 HEK-293T C381(1.07)  LDD1552  [4]
 LDCM0314  AC51 HEK-293T C353(1.14)  LDD1553  [4]
 LDCM0315  AC52 HEK-293T C381(0.89)  LDD1554  [4]
 LDCM0317  AC54 HEK-293T C381(0.91)  LDD1556  [4]
 LDCM0318  AC55 HEK-293T C381(1.01)  LDD1557  [4]
 LDCM0319  AC56 HEK-293T C381(1.15)  LDD1558  [4]
 LDCM0321  AC58 HEK-293T C381(1.08)  LDD1560  [4]
 LDCM0322  AC59 HEK-293T C353(1.04)  LDD1561  [4]
 LDCM0323  AC6 HEK-293T C381(1.09)  LDD1562  [4]
 LDCM0324  AC60 HEK-293T C381(0.94)  LDD1563  [4]
 LDCM0326  AC62 HEK-293T C381(0.91)  LDD1565  [4]
 LDCM0327  AC63 HEK-293T C381(1.07)  LDD1566  [4]
 LDCM0328  AC64 HEK-293T C381(1.36)  LDD1567  [4]
 LDCM0334  AC7 HEK-293T C381(0.90)  LDD1568  [4]
 LDCM0345  AC8 HEK-293T C381(1.22)  LDD1569  [4]
 LDCM0275  AKOS034007705 HEK-293T C381(1.10)  LDD1514  [4]
 LDCM0083  Avasimibe A-549 4.94  LDD0143  [3]
 LDCM0367  CL1 HEK-293T C313(1.13)  LDD1571  [4]
 LDCM0368  CL10 HEK-293T C381(0.63)  LDD1572  [4]
 LDCM0370  CL101 HEK-293T C313(0.99)  LDD1574  [4]
 LDCM0371  CL102 HEK-293T C313(0.95); C353(1.04)  LDD1575  [4]
 LDCM0372  CL103 HEK-293T C313(1.03); C353(1.02)  LDD1576  [4]
 LDCM0374  CL105 HEK-293T C313(1.04)  LDD1578  [4]
 LDCM0375  CL106 HEK-293T C313(1.13); C353(1.17)  LDD1579  [4]
 LDCM0376  CL107 HEK-293T C313(0.96); C353(1.12)  LDD1580  [4]
 LDCM0378  CL109 HEK-293T C313(1.10)  LDD1582  [4]
 LDCM0379  CL11 HEK-293T C381(0.89)  LDD1583  [4]
 LDCM0380  CL110 HEK-293T C313(0.98); C353(1.12)  LDD1584  [4]
 LDCM0381  CL111 HEK-293T C313(0.91); C353(0.99)  LDD1585  [4]
 LDCM0383  CL113 HEK-293T C313(0.98)  LDD1587  [4]
 LDCM0384  CL114 HEK-293T C313(1.06); C353(0.99)  LDD1588  [4]
 LDCM0385  CL115 HEK-293T C313(0.89); C353(1.13)  LDD1589  [4]
 LDCM0387  CL117 HEK-293T C313(0.93)  LDD1591  [4]
 LDCM0388  CL118 HEK-293T C313(1.03); C353(1.17)  LDD1592  [4]
 LDCM0389  CL119 HEK-293T C313(0.92); C353(1.00)  LDD1593  [4]
 LDCM0390  CL12 HEK-293T C381(1.09)  LDD1594  [4]
 LDCM0392  CL121 HEK-293T C313(1.06)  LDD1596  [4]
 LDCM0393  CL122 HEK-293T C313(1.13); C353(1.04)  LDD1597  [4]
 LDCM0394  CL123 HEK-293T C313(1.00); C353(0.95)  LDD1598  [4]
 LDCM0396  CL125 HEK-293T C313(1.27)  LDD1600  [4]
 LDCM0397  CL126 HEK-293T C313(1.04); C353(1.08)  LDD1601  [4]
 LDCM0398  CL127 HEK-293T C313(1.02); C353(1.08)  LDD1602  [4]
 LDCM0400  CL13 HEK-293T C313(1.03)  LDD1604  [4]
 LDCM0401  CL14 HEK-293T C313(1.22); C353(1.03)  LDD1605  [4]
 LDCM0402  CL15 HEK-293T C313(1.02); C353(0.90)  LDD1606  [4]
 LDCM0405  CL18 HEK-293T C381(1.14)  LDD1609  [4]
 LDCM0406  CL19 HEK-293T C353(0.92)  LDD1610  [4]
 LDCM0407  CL2 HEK-293T C313(1.25); C353(1.20)  LDD1611  [4]
 LDCM0408  CL20 HEK-293T C381(0.86)  LDD1612  [4]
 LDCM0410  CL22 HEK-293T C381(0.72)  LDD1614  [4]
 LDCM0411  CL23 HEK-293T C381(0.80)  LDD1615  [4]
 LDCM0412  CL24 HEK-293T C381(0.82)  LDD1616  [4]
 LDCM0413  CL25 HEK-293T C313(1.14)  LDD1617  [4]
 LDCM0414  CL26 HEK-293T C313(0.93); C353(1.09)  LDD1618  [4]
 LDCM0415  CL27 HEK-293T C313(0.96); C353(0.99)  LDD1619  [4]
 LDCM0418  CL3 HEK-293T C313(1.09); C353(1.09)  LDD1622  [4]
 LDCM0419  CL30 HEK-293T C381(1.09)  LDD1623  [4]
 LDCM0420  CL31 HEK-293T C353(1.06)  LDD1624  [4]
 LDCM0421  CL32 HEK-293T C381(0.83)  LDD1625  [4]
 LDCM0423  CL34 HEK-293T C381(0.73)  LDD1627  [4]
 LDCM0424  CL35 HEK-293T C381(0.68)  LDD1628  [4]
 LDCM0425  CL36 HEK-293T C381(0.95)  LDD1629  [4]
 LDCM0426  CL37 HEK-293T C313(1.20)  LDD1630  [4]
 LDCM0428  CL39 HEK-293T C313(1.15); C353(1.06)  LDD1632  [4]
 LDCM0432  CL42 HEK-293T C381(0.98)  LDD1636  [4]
 LDCM0433  CL43 HEK-293T C353(1.08)  LDD1637  [4]
 LDCM0434  CL44 HEK-293T C381(0.83)  LDD1638  [4]
 LDCM0436  CL46 HEK-293T C381(1.01)  LDD1640  [4]
 LDCM0437  CL47 HEK-293T C381(0.89)  LDD1641  [4]
 LDCM0438  CL48 HEK-293T C381(0.75)  LDD1642  [4]
 LDCM0439  CL49 HEK-293T C313(1.33)  LDD1643  [4]
 LDCM0441  CL50 HEK-293T C313(1.20); C353(1.23)  LDD1645  [4]
 LDCM0445  CL54 HEK-293T C381(1.02)  LDD1648  [4]
 LDCM0446  CL55 HEK-293T C353(1.07)  LDD1649  [4]
 LDCM0447  CL56 HEK-293T C381(0.81)  LDD1650  [4]
 LDCM0449  CL58 HEK-293T C381(0.78)  LDD1652  [4]
 LDCM0450  CL59 HEK-293T C381(0.86)  LDD1653  [4]
 LDCM0451  CL6 HEK-293T C381(0.83)  LDD1654  [4]
 LDCM0452  CL60 HEK-293T C381(0.89)  LDD1655  [4]
 LDCM0453  CL61 HEK-293T C313(1.14)  LDD1656  [4]
 LDCM0454  CL62 HEK-293T C313(1.04); C353(1.17)  LDD1657  [4]
 LDCM0455  CL63 HEK-293T C313(1.01); C353(1.07)  LDD1658  [4]
 LDCM0458  CL66 HEK-293T C381(1.03)  LDD1661  [4]
 LDCM0459  CL67 HEK-293T C353(0.95)  LDD1662  [4]
 LDCM0460  CL68 HEK-293T C381(0.83)  LDD1663  [4]
 LDCM0462  CL7 HEK-293T C353(1.04)  LDD1665  [4]
 LDCM0463  CL70 HEK-293T C381(0.86)  LDD1666  [4]
 LDCM0464  CL71 HEK-293T C381(0.99)  LDD1667  [4]
 LDCM0465  CL72 HEK-293T C381(1.10)  LDD1668  [4]
 LDCM0466  CL73 HEK-293T C313(1.18)  LDD1669  [4]
 LDCM0467  CL74 HEK-293T C313(1.13); C353(1.14)  LDD1670  [4]
 LDCM0471  CL78 HEK-293T C381(1.05)  LDD1674  [4]
 LDCM0472  CL79 HEK-293T C353(1.04)  LDD1675  [4]
 LDCM0473  CL8 HEK-293T C381(0.90)  LDD1676  [4]
 LDCM0474  CL80 HEK-293T C381(1.05)  LDD1677  [4]
 LDCM0476  CL82 HEK-293T C381(1.13)  LDD1679  [4]
 LDCM0477  CL83 HEK-293T C381(0.90)  LDD1680  [4]
 LDCM0478  CL84 HEK-293T C381(0.96)  LDD1681  [4]
 LDCM0479  CL85 HEK-293T C313(1.24)  LDD1682  [4]
 LDCM0480  CL86 HEK-293T C313(1.18); C353(1.13)  LDD1683  [4]
 LDCM0481  CL87 HEK-293T C313(0.97); C353(1.01)  LDD1684  [4]
 LDCM0485  CL90 HEK-293T C381(0.56)  LDD1688  [4]
 LDCM0486  CL91 HEK-293T C353(1.05)  LDD1689  [4]
 LDCM0487  CL92 HEK-293T C381(0.94)  LDD1690  [4]
 LDCM0489  CL94 HEK-293T C381(0.79)  LDD1692  [4]
 LDCM0490  CL95 HEK-293T C381(0.65)  LDD1693  [4]
 LDCM0491  CL96 HEK-293T C381(1.04)  LDD1694  [4]
 LDCM0492  CL97 HEK-293T C313(1.19)  LDD1695  [4]
 LDCM0493  CL98 HEK-293T C313(1.13); C353(1.13)  LDD1696  [4]
 LDCM0494  CL99 HEK-293T C313(1.03); C353(1.10)  LDD1697  [4]
 LDCM0495  E2913 HEK-293T C313(1.10); C353(1.15)  LDD1698  [4]
 LDCM0082  FK866 A-549 2.06  LDD0142  [3]
 LDCM0468  Fragment33 HEK-293T C313(1.07); C353(1.17)  LDD1671  [4]
 LDCM0427  Fragment51 HEK-293T C313(0.94); C353(1.09)  LDD1631  [4]
 LDCM0022  KB02 HEK-293T C353(0.99)  LDD1492  [4]
 LDCM0023  KB03 HEK-293T C353(0.79)  LDD1497  [4]
 LDCM0024  KB05 IGR37 C491(2.44)  LDD3314  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Peroxynitrite isomerase THAP4 (THAP4) Nitrobindin family Q8WY91
Retinol dehydrogenase 10 (RDH10) Short-chain dehydrogenases/reductases (SDR) family Q8IZV5
Estradiol 17-beta-dehydrogenase 11 (HSD17B11) Short-chain dehydrogenases/reductases (SDR) family Q8NBQ5
GTP-binding protein SAR1a (SAR1A) SAR1 family Q9NR31
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Syntaxin-1A (STX1A) Syntaxin family Q16623
Vesicle-associated membrane protein-associated protein A (VAPA) VAMP-associated protein (VAP) (TC 9.B.17) family Q9P0L0
Vesicle-associated membrane protein-associated protein B/C (VAPB) VAMP-associated protein (VAP) (TC 9.B.17) family O95292
Cytokine and receptor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CKLF-like MARVEL transmembrane domain-containing protein 5 (CMTM5) Chemokine-like factor family Q96DZ9
Tumor necrosis factor receptor superfamily member 10D (TNFRSF10D) . Q9UBN6
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Diablo IAP-binding mitochondrial protein (DIABLO) . Q9NR28
Type-1 angiotensin II receptor-associated protein (AGTRAP) . Q6RW13

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
3 A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells. Cell. 2015 Jun 18;161(7):1668-80. doi: 10.1016/j.cell.2015.05.045.
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402