Details of the Target

General Information of Target

Target ID LDTP06072
Target Name Dedicator of cytokinesis protein 1 (DOCK1)
Gene Name DOCK1
Gene ID 1793
Synonyms
Dedicator of cytokinesis protein 1; 180 kDa protein downstream of CRK; DOCK180
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTRWVPTKREEKYGVAFYNYDARGADELSLQIGDTVHILETYEGWYRGYTLRKKSKKGIF
PASYIHLKEAIVEGKGQHETVIPGDLPLIQEVTTTLREWSTIWRQLYVQDNREMFRSVRH
MIYDLIEWRSQILSGTLPQDELKELKKKVTAKIDYGNRILDLDLVVRDEDGNILDPELTS
TISLFRAHEIASKQVEERLQEEKSQKQNIDINRQAKFAATPSLALFVNLKNVVCKIGEDA
EVLMSLYDPVESKFISENYLVRWSSSGLPKDIDRLHNLRAVFTDLGSKDLKREKISFVCQ
IVRVGRMELRDNNTRKLTSGLRRPFGVAVMDVTDIINGKVDDEDKQHFIPFQPVAGENDF
LQTVINKVIAAKEVNHKGQGLWVTLKLLPGDIHQIRKEFPHLVDRTTAVARKTGFPEIIM
PGDVRNDIYVTLVQGDFDKGSKTTAKNVEVTVSVYDEDGKRLEHVIFPGAGDEAISEYKS
VIYYQVKQPRWFETVKVAIPIEDVNRSHLRFTFRHRSSQDSKDKSEKIFALAFVKLMRYD
GTTLRDGEHDLIVYKAEAKKLEDAATYLSLPSTKAELEEKGHSATGKSMQSLGSCTISKD
SFQISTLVCSTKLTQNVDLLGLLKWRSNTSLLQQNLRQLMKVDGGEVVKFLQDTLDALFN
IMMENSESETFDTLVFDALVFIIGLIADRKFQHFNPVLETYIKKHFSATLAYTKLTKVLK
NYVDGAEKPGVNEQLYKAMKALESIFKFIVRSRILFNQLYENKGEADFVESLLQLFRSIN
DMMSSMSDQTVRVKGAALKYLPTIVNDVKLVFDPKELSKMFTEFILNVPMGLLTIQKLYC
LIEIVHSDLFTQHDCREILLPMMTDQLKYHLERQEDLEACCQLLSHILEVLYRKDVGPTQ
RHVQIIMEKLLRTVNRTVISMGRDSELIGNFVACMTAILRQMEDYHYAHLIKTFGKMRTD
VVDFLMETFIMFKNLIGKNVYPFDWVIMNMVQNKVFLRAINQYADMLNKKFLDQANFELQ
LWNNYFHLAVAFLTQESLQLENFSSAKRAKILNKYGDMRRQIGFEIRDMWYNLGQHKIKF
IPEMVGPILEMTLIPETELRKATIPIFFDMMQCEFHSTRSFQMFENEIITKLDHEVEGGR
GDEQYKVLFDKILLEHCRKHKYLAKTGETFVKLVVRLMERLLDYRTIMHDENKENRMSCT
VNVLNFYKEIEREEMYIRYLYKLCDLHKECDNYTEAAYTLLLHAKLLKWSEDVCVAHLTQ
RDGYQATTQGQLKEQLYQEIIHYFDKGKMWEEAIALGKELAEQYENEMFDYEQLSELLKK
QAQFYENIVKVIRPKPDYFAVGYYGQGFPTFLRGKVFIYRGKEYERREDFEARLLTQFPN
AEKMKTTSPPGDDIKNSPGQYIQCFTVKPKLDLPPKFHRPVSEQIVSFYRVNEVQRFEYS
RPIRKGEKNPDNEFANMWIERTIYTTAYKLPGILRWFEVKSVFMVEISPLENAIETMQLT
NDKINSMVQQHLDDPSLPINPLSMLLNGIVDPAVMGGFANYEKAFFTDRYLQEHPEAHEK
IEKLKDLIAWQIPFLAEGIRIHGDKVTEALRPFHERMEACFKQLKEKVEKEYGVRIMPSS
LDDRRGSRPRSMVRSFTMPSSSRPLSVASVSSLSSDSTPSRPGSDGFALEPLLPKKMHSR
SQDKLDKDDLEKEKKDKKKEKRNSKHQEIFEKEFKPTDISLQQSEAVILSETISPLRPQR
PKSQVMNVIGSERRFSVSPSSPSSQQTPPPVTPRAKLSFSMQSSLELNGMTGADVADVPP
PLPLKGSVADYGNLMENQDLLGSPTPPPPPPHQRHLPPPLPSKTPPPPPPKTTRKQASVD
SGIVQ
Target Bioclass
Other
Family
DOCK family
Subcellular location
Cytoplasm
Function
Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen. Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1.
Uniprot ID
Q14185
Ensemble ID
ENST00000280333.9
HGNC ID
HGNC:2987
ChEMBL ID
CHEMBL4523288

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K397(10.00)  LDD0277  [1]
BTD
 Probe Info  		C1600(0.43)  LDD2109  [2]
HHS-475
 Probe Info  		Y1468(3.39)  LDD0264  [3]
DBIA
 Probe Info  		C595(1.77)  LDD0080  [4]
IA-alkyne
 Probe Info  		C1157(0.00); C1224(0.00); C1404(0.00); C595(0.00)  LDD0165  [5]
IPM
 Probe Info  		C595(0.00); C1254(0.00)  LDD2156  [6]
HHS-465
 Probe Info  		K1469(0.00); Y1468(0.00)  LDD2240  [7]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C017
 Probe Info  		5.58  LDD1725  [8]
C056
 Probe Info  		25.81  LDD1753  [8]
C087
 Probe Info  		7.41  LDD1779  [8]
C138
 Probe Info  		7.36  LDD1820  [8]
C169
 Probe Info  		19.84  LDD1849  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C299(1.20)  LDD0812  [4]
 LDCM0215  AC10 HCT 116 C595(1.18)  LDD0532  [4]
 LDCM0216  AC100 HEK-293T C595(0.97)  LDD0814  [4]
 LDCM0217  AC101 HEK-293T C595(0.89)  LDD0815  [4]
 LDCM0218  AC102 HEK-293T C595(0.68)  LDD0816  [4]
 LDCM0219  AC103 HEK-293T C595(1.05)  LDD0817  [4]
 LDCM0220  AC104 HEK-293T C595(0.88)  LDD0818  [4]
 LDCM0221  AC105 HEK-293T C595(0.93)  LDD0819  [4]
 LDCM0222  AC106 HEK-293T C595(0.77)  LDD0820  [4]
 LDCM0223  AC107 HEK-293T C595(0.80)  LDD0821  [4]
 LDCM0224  AC108 HEK-293T C595(0.82)  LDD0822  [4]
 LDCM0225  AC109 HEK-293T C595(0.81)  LDD0823  [4]
 LDCM0226  AC11 HCT 116 C595(1.15)  LDD0543  [4]
 LDCM0227  AC110 HEK-293T C595(0.89)  LDD0825  [4]
 LDCM0228  AC111 HEK-293T C595(0.74)  LDD0826  [4]
 LDCM0229  AC112 HEK-293T C595(0.88)  LDD0827  [4]
 LDCM0230  AC113 HCT 116 C595(0.91)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C595(1.02)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C595(0.96)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C595(0.96)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C595(0.92)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C595(1.07)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C595(0.92)  LDD0553  [4]
 LDCM0237  AC12 HCT 116 C595(1.21)  LDD0554  [4]
 LDCM0238  AC120 HCT 116 C595(0.98)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C595(0.87)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C595(0.98)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C595(0.93)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C595(0.99)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C595(0.99)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C595(1.01)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C595(0.95)  LDD0562  [4]
 LDCM0246  AC128 HEK-293T C299(0.87)  LDD0844  [4]
 LDCM0247  AC129 HEK-293T C299(0.95)  LDD0845  [4]
 LDCM0249  AC130 HEK-293T C299(0.91)  LDD0847  [4]
 LDCM0250  AC131 HEK-293T C299(0.90)  LDD0848  [4]
 LDCM0251  AC132 HEK-293T C299(1.07)  LDD0849  [4]
 LDCM0252  AC133 HEK-293T C299(1.53)  LDD0850  [4]
 LDCM0253  AC134 HEK-293T C299(1.18)  LDD0851  [4]
 LDCM0254  AC135 HEK-293T C299(1.09)  LDD0852  [4]
 LDCM0255  AC136 HEK-293T C299(1.08)  LDD0853  [4]
 LDCM0256  AC137 HEK-293T C299(1.24)  LDD0854  [4]
 LDCM0257  AC138 HEK-293T C299(1.09)  LDD0855  [4]
 LDCM0258  AC139 HEK-293T C299(1.13)  LDD0856  [4]
 LDCM0259  AC14 HCT 116 C595(1.31)  LDD0576  [4]
 LDCM0260  AC140 HEK-293T C299(0.94)  LDD0858  [4]
 LDCM0261  AC141 HEK-293T C299(1.22)  LDD0859  [4]
 LDCM0262  AC142 HEK-293T C299(1.14)  LDD0860  [4]
 LDCM0263  AC143 HCT 116 C595(1.29)  LDD0580  [4]
 LDCM0264  AC144 HCT 116 C595(1.02)  LDD0581  [4]
 LDCM0265  AC145 HCT 116 C595(1.04)  LDD0582  [4]
 LDCM0266  AC146 HCT 116 C595(1.17)  LDD0583  [4]
 LDCM0267  AC147 HCT 116 C595(0.87)  LDD0584  [4]
 LDCM0268  AC148 HCT 116 C595(1.02)  LDD0585  [4]
 LDCM0269  AC149 HCT 116 C595(1.25)  LDD0586  [4]
 LDCM0270  AC15 HCT 116 C595(1.56)  LDD0587  [4]
 LDCM0271  AC150 HCT 116 C595(1.12)  LDD0588  [4]
 LDCM0272  AC151 HCT 116 C595(1.01)  LDD0589  [4]
 LDCM0273  AC152 HCT 116 C595(1.09)  LDD0590  [4]
 LDCM0274  AC153 HCT 116 C595(1.38)  LDD0591  [4]
 LDCM0621  AC154 HCT 116 C595(1.09)  LDD2158  [4]
 LDCM0622  AC155 HCT 116 C595(1.14)  LDD2159  [4]
 LDCM0623  AC156 HCT 116 C595(1.13)  LDD2160  [4]
 LDCM0624  AC157 HCT 116 C595(1.16)  LDD2161  [4]
 LDCM0276  AC17 HCT 116 C595(1.03)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C595(0.87)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C595(0.96)  LDD0595  [4]
 LDCM0279  AC2 HEK-293T C299(1.15)  LDD0877  [4]
 LDCM0280  AC20 HCT 116 C595(0.91)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C595(0.82)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C595(1.03)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C595(0.92)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C595(0.97)  LDD0601  [4]
 LDCM0285  AC25 HCT 116 C595(1.03)  LDD0602  [4]
 LDCM0286  AC26 HCT 116 C595(1.28)  LDD0603  [4]
 LDCM0287  AC27 HCT 116 C595(1.26)  LDD0604  [4]
 LDCM0288  AC28 HCT 116 C595(1.23)  LDD0605  [4]
 LDCM0289  AC29 HCT 116 C595(1.22)  LDD0606  [4]
 LDCM0290  AC3 HEK-293T C299(1.00)  LDD0888  [4]
 LDCM0291  AC30 HCT 116 C595(1.32)  LDD0608  [4]
 LDCM0292  AC31 HCT 116 C595(1.27)  LDD0609  [4]
 LDCM0293  AC32 HCT 116 C595(1.45)  LDD0610  [4]
 LDCM0294  AC33 HCT 116 C595(1.34)  LDD0611  [4]
 LDCM0295  AC34 HCT 116 C595(1.45)  LDD0612  [4]
 LDCM0296  AC35 HCT 116 C595(0.76)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C595(0.86)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C595(0.75)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C595(1.12)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C595(1.05)  LDD0617  [4]
 LDCM0301  AC4 HEK-293T C299(1.08)  LDD0899  [4]
 LDCM0302  AC40 HCT 116 C595(0.90)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C595(0.82)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C595(0.91)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C595(1.20)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C595(0.80)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C595(0.73)  LDD0624  [4]
 LDCM0308  AC46 HCT 116 C595(1.08)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C595(1.21)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C595(1.04)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C595(1.05)  LDD0628  [4]
 LDCM0312  AC5 HEK-293T C299(1.10)  LDD0910  [4]
 LDCM0313  AC50 HCT 116 C595(1.01)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C595(0.94)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C595(1.01)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C595(1.10)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C595(1.03)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C595(1.51)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C595(1.39)  LDD0636  [4]
 LDCM0320  AC57 HEK-293T C1230(1.16); C1404(1.16); C595(0.95)  LDD0918  [4]
 LDCM0321  AC58 HEK-293T C1230(1.14); C1404(1.14); C595(1.06)  LDD0919  [4]
 LDCM0322  AC59 HEK-293T C1230(1.03); C1404(1.03); C595(0.91)  LDD0920  [4]
 LDCM0323  AC6 HCT 116 C595(1.31)  LDD0640  [4]
 LDCM0324  AC60 HEK-293T C1230(1.52); C1404(1.52); C595(1.10)  LDD0922  [4]
 LDCM0325  AC61 HEK-293T C1230(1.27); C1404(1.27); C595(1.08)  LDD0923  [4]
 LDCM0326  AC62 HEK-293T C1230(1.08); C1404(1.08); C595(1.11)  LDD0924  [4]
 LDCM0327  AC63 HEK-293T C1230(1.69); C1404(1.69); C595(1.00)  LDD0925  [4]
 LDCM0328  AC64 HEK-293T C1230(1.23); C1404(1.23); C595(1.09)  LDD0926  [4]
 LDCM0329  AC65 HEK-293T C1230(1.34); C1404(1.34); C595(1.09)  LDD0927  [4]
 LDCM0330  AC66 HEK-293T C1230(1.18); C1404(1.18); C595(1.00)  LDD0928  [4]
 LDCM0331  AC67 HEK-293T C1230(1.31); C1404(1.31); C595(1.08)  LDD0929  [4]
 LDCM0332  AC68 HCT 116 C595(0.91)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C595(0.85)  LDD0650  [4]
 LDCM0334  AC7 HCT 116 C595(0.99)  LDD0651  [4]
 LDCM0335  AC70 HCT 116 C595(0.98)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C595(0.94)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C595(1.03)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C595(1.09)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C595(1.00)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C595(0.94)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C595(0.97)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C595(1.00)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C595(0.95)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C595(1.08)  LDD0661  [4]
 LDCM0345  AC8 HCT 116 C595(1.23)  LDD0662  [4]
 LDCM0346  AC80 HCT 116 C595(1.14)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C595(1.01)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C595(1.11)  LDD0665  [4]
 LDCM0349  AC83 HCT 116 C595(1.36)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C595(1.54)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C595(1.20)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C595(1.36)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C595(0.96)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C595(1.03)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C595(1.05)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C595(1.04)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C595(1.32)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C595(1.24)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C595(1.19)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C595(1.31)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C595(1.13)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C595(1.35)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C595(1.24)  LDD0681  [4]
 LDCM0365  AC98 HEK-293T C595(0.76)  LDD0963  [4]
 LDCM0366  AC99 HEK-293T C595(0.85)  LDD0964  [4]
 LDCM0248  AKOS034007472 HCT 116 C595(1.04)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C595(1.27)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C595(1.61)  LDD0592  [4]
 LDCM0367  CL1 HCT 116 C595(1.01)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C595(1.16)  LDD0685  [4]
 LDCM0369  CL100 HEK-293T C299(1.43)  LDD0967  [4]
 LDCM0370  CL101 HCT 116 C595(1.14)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C595(0.97)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C595(1.03)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C595(1.45)  LDD0690  [4]
 LDCM0374  CL105 HCT 116 C595(0.90)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C595(0.82)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C595(0.87)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C595(0.97)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C595(0.91)  LDD0695  [4]
 LDCM0379  CL11 HCT 116 C595(1.01)  LDD0696  [4]
 LDCM0380  CL110 HCT 116 C595(1.01)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C595(1.20)  LDD0698  [4]
 LDCM0382  CL112 HCT 116 C595(1.19)  LDD0699  [4]
 LDCM0383  CL113 HCT 116 C595(1.37)  LDD0700  [4]
 LDCM0384  CL114 HCT 116 C595(1.31)  LDD0701  [4]
 LDCM0385  CL115 HCT 116 C595(1.41)  LDD0702  [4]
 LDCM0386  CL116 HCT 116 C595(1.24)  LDD0703  [4]
 LDCM0387  CL117 HCT 116 C595(1.12)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C595(0.88)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C595(0.92)  LDD0706  [4]
 LDCM0390  CL12 HCT 116 C595(1.20)  LDD0707  [4]
 LDCM0391  CL120 HCT 116 C595(1.04)  LDD0708  [4]
 LDCM0392  CL121 HCT 116 C595(1.06)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C595(1.19)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C595(1.25)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C595(1.46)  LDD0712  [4]
 LDCM0396  CL125 HEK-293T C1230(1.31); C1404(1.31); C595(0.99)  LDD0994  [4]
 LDCM0397  CL126 HEK-293T C1230(1.19); C1404(1.19); C595(1.01)  LDD0995  [4]
 LDCM0398  CL127 HEK-293T C1230(1.17); C1404(1.17); C595(1.05)  LDD0996  [4]
 LDCM0399  CL128 HEK-293T C1230(1.17); C1404(1.17); C595(1.05)  LDD0997  [4]
 LDCM0400  CL13 HCT 116 C595(0.99)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C595(1.14)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C595(0.87)  LDD0719  [4]
 LDCM0403  CL16 HCT 116 C595(1.16)  LDD0720  [4]
 LDCM0404  CL17 HCT 116 C595(1.02)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C595(1.14)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C595(1.15)  LDD0723  [4]
 LDCM0407  CL2 HCT 116 C595(0.93)  LDD0724  [4]
 LDCM0408  CL20 HCT 116 C595(1.14)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C595(1.21)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C595(1.51)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C595(1.18)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C595(1.32)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C595(1.23)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C595(1.11)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C595(1.15)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C595(1.27)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C595(1.21)  LDD0734  [4]
 LDCM0418  CL3 HCT 116 C595(1.00)  LDD0735  [4]
 LDCM0419  CL30 HCT 116 C595(1.04)  LDD0736  [4]
 LDCM0420  CL31 HCT 116 C595(1.00)  LDD0737  [4]
 LDCM0421  CL32 HCT 116 C595(1.10)  LDD0738  [4]
 LDCM0422  CL33 HCT 116 C595(1.02)  LDD0739  [4]
 LDCM0423  CL34 HCT 116 C595(1.08)  LDD0740  [4]
 LDCM0424  CL35 HCT 116 C595(1.18)  LDD0741  [4]
 LDCM0425  CL36 HCT 116 C595(1.11)  LDD0742  [4]
 LDCM0426  CL37 HCT 116 C595(1.02)  LDD0743  [4]
 LDCM0428  CL39 HCT 116 C595(1.01)  LDD0745  [4]
 LDCM0429  CL4 HCT 116 C595(0.98)  LDD0746  [4]
 LDCM0430  CL40 HCT 116 C595(1.05)  LDD0747  [4]
 LDCM0431  CL41 HCT 116 C595(1.06)  LDD0748  [4]
 LDCM0432  CL42 HCT 116 C595(0.96)  LDD0749  [4]
 LDCM0433  CL43 HCT 116 C595(0.99)  LDD0750  [4]
 LDCM0434  CL44 HCT 116 C595(1.00)  LDD0751  [4]
 LDCM0435  CL45 HCT 116 C595(1.08)  LDD0752  [4]
 LDCM0436  CL46 HCT 116 C595(1.21)  LDD0753  [4]
 LDCM0437  CL47 HCT 116 C595(1.23)  LDD0754  [4]
 LDCM0438  CL48 HCT 116 C595(1.11)  LDD0755  [4]
 LDCM0439  CL49 HCT 116 C595(1.01)  LDD0756  [4]
 LDCM0440  CL5 HCT 116 C595(0.86)  LDD0757  [4]
 LDCM0441  CL50 HCT 116 C595(1.04)  LDD0758  [4]
 LDCM0442  CL51 HCT 116 C595(1.19)  LDD0759  [4]
 LDCM0443  CL52 HCT 116 C595(1.20)  LDD0760  [4]
 LDCM0444  CL53 HCT 116 C595(1.05)  LDD0761  [4]
 LDCM0445  CL54 HCT 116 C595(1.03)  LDD0762  [4]
 LDCM0446  CL55 HCT 116 C595(0.93)  LDD0763  [4]
 LDCM0447  CL56 HCT 116 C595(1.17)  LDD0764  [4]
 LDCM0448  CL57 HCT 116 C595(1.19)  LDD0765  [4]
 LDCM0449  CL58 HCT 116 C595(1.04)  LDD0766  [4]
 LDCM0450  CL59 HCT 116 C595(1.08)  LDD0767  [4]
 LDCM0451  CL6 HCT 116 C595(1.02)  LDD0768  [4]
 LDCM0452  CL60 HCT 116 C595(1.07)  LDD0769  [4]
 LDCM0453  CL61 HCT 116 C595(1.01)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C595(1.02)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C595(0.99)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C595(1.02)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C595(0.96)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C595(1.00)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C595(0.88)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C595(0.91)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C595(1.01)  LDD0778  [4]
 LDCM0462  CL7 HCT 116 C595(1.18)  LDD0779  [4]
 LDCM0463  CL70 HCT 116 C595(1.09)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C595(0.90)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C595(1.04)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C595(0.93)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C595(0.86)  LDD0784  [4]
 LDCM0469  CL76 PaTu 8988t C595(1.19)  LDD1348  [4]
 LDCM0470  CL77 PaTu 8988t C595(1.27)  LDD1349  [4]
 LDCM0471  CL78 PaTu 8988t C595(1.25)  LDD1350  [4]
 LDCM0472  CL79 PaTu 8988t C595(1.18)  LDD1351  [4]
 LDCM0473  CL8 HCT 116 C595(1.43)  LDD0790  [4]
 LDCM0474  CL80 PaTu 8988t C595(1.39)  LDD1353  [4]
 LDCM0475  CL81 PaTu 8988t C595(1.48)  LDD1354  [4]
 LDCM0476  CL82 PaTu 8988t C595(1.44)  LDD1355  [4]
 LDCM0477  CL83 PaTu 8988t C595(1.22)  LDD1356  [4]
 LDCM0478  CL84 PaTu 8988t C595(1.66)  LDD1357  [4]
 LDCM0479  CL85 PaTu 8988t C595(1.21)  LDD1358  [4]
 LDCM0480  CL86 PaTu 8988t C595(1.49)  LDD1359  [4]
 LDCM0481  CL87 PaTu 8988t C595(1.90)  LDD1360  [4]
 LDCM0482  CL88 PaTu 8988t C595(1.71)  LDD1361  [4]
 LDCM0483  CL89 PaTu 8988t C595(1.67)  LDD1362  [4]
 LDCM0484  CL9 HCT 116 C595(1.12)  LDD0801  [4]
 LDCM0485  CL90 PaTu 8988t C595(1.66)  LDD1364  [4]
 LDCM0486  CL91 HEK-293T C299(1.15)  LDD1084  [4]
 LDCM0487  CL92 HEK-293T C299(1.01)  LDD1085  [4]
 LDCM0488  CL93 HEK-293T C299(1.02)  LDD1086  [4]
 LDCM0489  CL94 HEK-293T C299(1.33)  LDD1087  [4]
 LDCM0490  CL95 HEK-293T C299(1.35)  LDD1088  [4]
 LDCM0491  CL96 HEK-293T C299(1.08)  LDD1089  [4]
 LDCM0492  CL97 HEK-293T C299(1.22)  LDD1090  [4]
 LDCM0493  CL98 HEK-293T C299(1.03)  LDD1091  [4]
 LDCM0494  CL99 HEK-293T C299(1.05)  LDD1092  [4]
 LDCM0495  E2913 HEK-293T C595(0.90); C1113(0.85); C1230(1.03); C881(1.07)  LDD1698  [9]
 LDCM0468  Fragment33 HCT 116 C595(1.11)  LDD0785  [4]
 LDCM0427  Fragment51 HCT 116 C595(1.18)  LDD0744  [4]
 LDCM0116  HHS-0101 DM93 Y1468(3.39)  LDD0264  [3]
 LDCM0118  HHS-0301 DM93 Y1468(1.39)  LDD0266  [3]
 LDCM0119  HHS-0401 DM93 Y1468(0.96)  LDD0267  [3]
 LDCM0120  HHS-0701 DM93 Y1468(0.86)  LDD0268  [3]
 LDCM0022  KB02 HCT 116 C595(1.77)  LDD0080  [4]
 LDCM0023  KB03 HCT 116 C595(1.39)  LDD0081  [4]
 LDCM0024  KB05 HCT 116 C595(1.57)  LDD0082  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C1600(0.43)  LDD2109  [2]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C1600(1.72)  LDD2136  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ras-related C3 botulinum toxin substrate 1 (RAC1) Rho family P63000
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Adapter molecule crk (CRK) CRK family P46108
Growth factor receptor-bound protein 2 (GRB2) GRB2/sem-5/DRK family P62993
Engulfment and cell motility protein 1 (ELMO1) . Q92556
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A (ANKRD28) . O15084

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
7 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
8 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402