Details of the Target

General Information of Target

Target ID LDTP01577
Target Name Tumor necrosis factor alpha-induced protein 8 (TNFAIP8)
Gene Name TNFAIP8
Gene ID 25816
Synonyms
Tumor necrosis factor alpha-induced protein 8; TNF alpha-induced protein 8; Head and neck tumor and metastasis-related protein; MDC-3.13; NF-kappa-B-inducible DED-containing protein; NDED; SCC-S2; TNF-induced protein GG2-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MHSEAEESKEVATDVFNSKNLAVQAQKKILGKMVSKSIATTLIDDTSSEVLDELYRVTRE
YTQNKKEAEKIIKNLIKTVIKLAILYRNNQFNQDELALMEKFKKKVHQLAMTVVSFHQVD
YTFDRNVLSRLLNECREMLHQIIQRHLTAKSHGRVNNVFDHFSDCEFLAALYNPFGNFKP
HLQKLCDGINKMLDEENI
Target Bioclass
Other
Family
TNFAIP8 family
Subcellular location
Cytoplasm
Function
Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation.
Uniprot ID
O95379
Ensemble ID
ENST00000274456.6
HGNC ID
HGNC:17260

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
IM95 SNV: p.R145H .
RKO SNV: p.T41A .
SW1271 SNV: p.S47T .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y55(10.27)  LDD0260  [1]
STPyne
 Probe Info  		K150(5.22); K27(5.88); K32(2.78)  LDD0277  [2]
DBIA
 Probe Info  		C198(3.61)  LDD3370  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		C186(0.00); C165(0.00)  LDD0038  [4]
IA-alkyne
 Probe Info  		C186(0.00); C165(0.00)  LDD0036  [4]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [5]
Lodoacetamide azide
 Probe Info  		C186(0.00); C165(0.00)  LDD0037  [4]
IPM
 Probe Info  		C186(0.00); C165(0.00)  LDD2156  [6]
NAIA_5
 Probe Info  		N.A.  LDD2223  [7]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C056
 Probe Info  		29.65  LDD1753  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C186(1.00); C165(1.09)  LDD1507  [9]
 LDCM0226  AC11 HEK-293T C186(0.96)  LDD1509  [9]
 LDCM0237  AC12 HEK-293T C186(0.98); C165(1.16)  LDD1510  [9]
 LDCM0259  AC14 HEK-293T C186(1.00)  LDD1512  [9]
 LDCM0270  AC15 HEK-293T C186(0.98)  LDD1513  [9]
 LDCM0276  AC17 HEK-293T C186(0.97); C165(1.08)  LDD1515  [9]
 LDCM0278  AC19 HEK-293T C186(0.87)  LDD1517  [9]
 LDCM0280  AC20 HEK-293T C186(0.99); C165(1.17)  LDD1519  [9]
 LDCM0281  AC21 HEK-293T C186(1.04); C165(1.02)  LDD1520  [9]
 LDCM0282  AC22 HEK-293T C186(0.95)  LDD1521  [9]
 LDCM0283  AC23 HEK-293T C186(0.97)  LDD1522  [9]
 LDCM0284  AC24 HEK-293T C186(0.97); C165(1.11)  LDD1523  [9]
 LDCM0285  AC25 HEK-293T C186(0.97); C165(1.09)  LDD1524  [9]
 LDCM0287  AC27 HEK-293T C186(0.95)  LDD1526  [9]
 LDCM0288  AC28 HEK-293T C186(1.01); C165(1.17)  LDD1527  [9]
 LDCM0289  AC29 HEK-293T C186(0.98); C165(1.04)  LDD1528  [9]
 LDCM0290  AC3 HEK-293T C186(0.94)  LDD1529  [9]
 LDCM0291  AC30 HEK-293T C186(1.01)  LDD1530  [9]
 LDCM0292  AC31 HEK-293T C186(1.05)  LDD1531  [9]
 LDCM0293  AC32 HEK-293T C186(0.95); C165(1.15)  LDD1532  [9]
 LDCM0294  AC33 HEK-293T C186(0.94); C165(1.08)  LDD1533  [9]
 LDCM0296  AC35 HEK-293T C186(0.95)  LDD1535  [9]
 LDCM0297  AC36 HEK-293T C186(0.97); C165(1.16)  LDD1536  [9]
 LDCM0298  AC37 HEK-293T C186(0.93); C165(1.11)  LDD1537  [9]
 LDCM0299  AC38 HEK-293T C186(1.03)  LDD1538  [9]
 LDCM0300  AC39 HEK-293T C186(1.00)  LDD1539  [9]
 LDCM0301  AC4 HEK-293T C186(0.95); C165(1.15)  LDD1540  [9]
 LDCM0302  AC40 HEK-293T C186(0.95); C165(1.15)  LDD1541  [9]
 LDCM0303  AC41 HEK-293T C186(1.00); C165(1.15)  LDD1542  [9]
 LDCM0305  AC43 HEK-293T C186(0.94)  LDD1544  [9]
 LDCM0306  AC44 HEK-293T C186(1.01); C165(0.95)  LDD1545  [9]
 LDCM0307  AC45 HEK-293T C186(0.92); C165(1.04)  LDD1546  [9]
 LDCM0308  AC46 HEK-293T C186(0.98)  LDD1547  [9]
 LDCM0309  AC47 HEK-293T C186(0.96)  LDD1548  [9]
 LDCM0310  AC48 HEK-293T C186(0.91); C165(1.04)  LDD1549  [9]
 LDCM0311  AC49 HEK-293T C186(0.98); C165(1.08)  LDD1550  [9]
 LDCM0312  AC5 HEK-293T C186(0.99); C165(0.99)  LDD1551  [9]
 LDCM0314  AC51 HEK-293T C186(0.96)  LDD1553  [9]
 LDCM0315  AC52 HEK-293T C186(0.97); C165(1.15)  LDD1554  [9]
 LDCM0316  AC53 HEK-293T C186(0.96); C165(1.08)  LDD1555  [9]
 LDCM0317  AC54 HEK-293T C186(0.99)  LDD1556  [9]
 LDCM0318  AC55 HEK-293T C186(0.96)  LDD1557  [9]
 LDCM0319  AC56 HEK-293T C186(0.96); C165(1.02)  LDD1558  [9]
 LDCM0320  AC57 HEK-293T C186(0.96); C165(0.99)  LDD1559  [9]
 LDCM0322  AC59 HEK-293T C186(0.96)  LDD1561  [9]
 LDCM0323  AC6 HEK-293T C186(0.98)  LDD1562  [9]
 LDCM0324  AC60 HEK-293T C186(0.97); C165(1.11)  LDD1563  [9]
 LDCM0325  AC61 HEK-293T C186(0.95); C165(1.01)  LDD1564  [9]
 LDCM0326  AC62 HEK-293T C186(1.03)  LDD1565  [9]
 LDCM0327  AC63 HEK-293T C186(0.98)  LDD1566  [9]
 LDCM0328  AC64 HEK-293T C186(0.90); C165(1.07)  LDD1567  [9]
 LDCM0334  AC7 HEK-293T C186(0.97)  LDD1568  [9]
 LDCM0345  AC8 HEK-293T C186(0.90); C165(0.98)  LDD1569  [9]
 LDCM0248  AKOS034007472 HEK-293T C186(0.92); C165(1.06)  LDD1511  [9]
 LDCM0356  AKOS034007680 HEK-293T C186(0.98); C165(1.16)  LDD1570  [9]
 LDCM0275  AKOS034007705 HEK-293T C186(0.97); C165(1.18)  LDD1514  [9]
 LDCM0367  CL1 HEK-293T C186(1.03); C165(1.07)  LDD1571  [9]
 LDCM0368  CL10 HEK-293T C186(0.84)  LDD1572  [9]
 LDCM0369  CL100 HEK-293T C186(0.90)  LDD1573  [9]
 LDCM0370  CL101 HEK-293T C186(1.06); C165(1.06)  LDD1574  [9]
 LDCM0371  CL102 HEK-293T C186(0.97)  LDD1575  [9]
 LDCM0372  CL103 HEK-293T C186(0.93)  LDD1576  [9]
 LDCM0373  CL104 HEK-293T C186(0.95)  LDD1577  [9]
 LDCM0374  CL105 HEK-293T C186(1.00); C165(1.20)  LDD1578  [9]
 LDCM0375  CL106 HEK-293T C186(0.97)  LDD1579  [9]
 LDCM0376  CL107 HEK-293T C186(1.03)  LDD1580  [9]
 LDCM0377  CL108 HEK-293T C186(1.00)  LDD1581  [9]
 LDCM0378  CL109 HEK-293T C186(0.99); C165(1.49)  LDD1582  [9]
 LDCM0379  CL11 HEK-293T C186(1.01)  LDD1583  [9]
 LDCM0380  CL110 HEK-293T C186(1.12)  LDD1584  [9]
 LDCM0381  CL111 HEK-293T C186(0.99)  LDD1585  [9]
 LDCM0382  CL112 HEK-293T C186(0.92)  LDD1586  [9]
 LDCM0383  CL113 HEK-293T C186(1.12); C165(0.98)  LDD1587  [9]
 LDCM0384  CL114 HEK-293T C186(1.00)  LDD1588  [9]
 LDCM0385  CL115 HEK-293T C186(0.90)  LDD1589  [9]
 LDCM0386  CL116 HEK-293T C186(0.95)  LDD1590  [9]
 LDCM0387  CL117 HEK-293T C186(1.16); C165(0.94)  LDD1591  [9]
 LDCM0388  CL118 HEK-293T C186(0.93)  LDD1592  [9]
 LDCM0389  CL119 HEK-293T C186(0.95)  LDD1593  [9]
 LDCM0390  CL12 HEK-293T C186(0.85); C165(1.55)  LDD1594  [9]
 LDCM0391  CL120 HEK-293T C186(0.98)  LDD1595  [9]
 LDCM0392  CL121 HEK-293T C186(1.01); C165(0.95)  LDD1596  [9]
 LDCM0393  CL122 HEK-293T C186(0.99)  LDD1597  [9]
 LDCM0394  CL123 HEK-293T C186(0.94)  LDD1598  [9]
 LDCM0395  CL124 HEK-293T C186(0.89)  LDD1599  [9]
 LDCM0396  CL125 HEK-293T C186(1.00); C165(0.86)  LDD1600  [9]
 LDCM0397  CL126 HEK-293T C186(0.90)  LDD1601  [9]
 LDCM0398  CL127 HEK-293T C186(0.93)  LDD1602  [9]
 LDCM0399  CL128 HEK-293T C186(1.00)  LDD1603  [9]
 LDCM0400  CL13 HEK-293T C186(1.00); C165(1.04)  LDD1604  [9]
 LDCM0401  CL14 HEK-293T C186(0.93)  LDD1605  [9]
 LDCM0402  CL15 HEK-293T C186(0.93)  LDD1606  [9]
 LDCM0403  CL16 HEK-293T C186(0.94)  LDD1607  [9]
 LDCM0404  CL17 HEK-293T C186(0.91); C165(1.88)  LDD1608  [9]
 LDCM0406  CL19 HEK-293T C186(0.86)  LDD1610  [9]
 LDCM0407  CL2 HEK-293T C186(0.97)  LDD1611  [9]
 LDCM0408  CL20 HEK-293T C186(1.06); C165(0.77)  LDD1612  [9]
 LDCM0409  CL21 HEK-293T C186(0.85); C165(1.10)  LDD1613  [9]
 LDCM0410  CL22 HEK-293T C186(0.90)  LDD1614  [9]
 LDCM0411  CL23 HEK-293T C186(1.09)  LDD1615  [9]
 LDCM0412  CL24 HEK-293T C186(0.95); C165(1.45)  LDD1616  [9]
 LDCM0413  CL25 HEK-293T C186(0.98); C165(1.43)  LDD1617  [9]
 LDCM0414  CL26 HEK-293T C186(1.01)  LDD1618  [9]
 LDCM0415  CL27 HEK-293T C186(0.96)  LDD1619  [9]
 LDCM0416  CL28 HEK-293T C186(0.93)  LDD1620  [9]
 LDCM0417  CL29 HEK-293T C186(1.05); C165(0.99)  LDD1621  [9]
 LDCM0418  CL3 HEK-293T C186(0.87)  LDD1622  [9]
 LDCM0420  CL31 HEK-293T C186(0.95)  LDD1624  [9]
 LDCM0421  CL32 HEK-293T C186(1.00); C165(0.73)  LDD1625  [9]
 LDCM0422  CL33 HEK-293T C186(0.88); C165(1.00)  LDD1626  [9]
 LDCM0423  CL34 HEK-293T C186(0.95)  LDD1627  [9]
 LDCM0424  CL35 HEK-293T C186(0.95)  LDD1628  [9]
 LDCM0425  CL36 HEK-293T C186(0.88); C165(1.57)  LDD1629  [9]
 LDCM0426  CL37 HEK-293T C186(0.98); C165(1.10)  LDD1630  [9]
 LDCM0428  CL39 HEK-293T C186(0.90)  LDD1632  [9]
 LDCM0429  CL4 HEK-293T C186(0.84)  LDD1633  [9]
 LDCM0430  CL40 HEK-293T C186(0.99)  LDD1634  [9]
 LDCM0431  CL41 HEK-293T C186(0.95); C165(1.43)  LDD1635  [9]
 LDCM0433  CL43 HEK-293T C186(1.00)  LDD1637  [9]
 LDCM0434  CL44 HEK-293T C186(0.98); C165(1.04)  LDD1638  [9]
 LDCM0435  CL45 HEK-293T C186(0.86); C165(1.18)  LDD1639  [9]
 LDCM0436  CL46 HEK-293T C186(1.00)  LDD1640  [9]
 LDCM0437  CL47 HEK-293T C186(0.91)  LDD1641  [9]
 LDCM0438  CL48 HEK-293T C186(0.93); C165(1.59)  LDD1642  [9]
 LDCM0439  CL49 HEK-293T C186(1.12); C165(0.98)  LDD1643  [9]
 LDCM0440  CL5 HEK-293T C186(0.97); C165(0.98)  LDD1644  [9]
 LDCM0441  CL50 HEK-293T C186(1.01)  LDD1645  [9]
 LDCM0443  CL52 HEK-293T C186(0.93)  LDD1646  [9]
 LDCM0444  CL53 HEK-293T C186(0.96); C165(1.82)  LDD1647  [9]
 LDCM0446  CL55 HEK-293T C186(0.94)  LDD1649  [9]
 LDCM0447  CL56 HEK-293T C186(0.97); C165(0.82)  LDD1650  [9]
 LDCM0448  CL57 HEK-293T C186(0.80); C165(1.25)  LDD1651  [9]
 LDCM0449  CL58 HEK-293T C186(0.89)  LDD1652  [9]
 LDCM0450  CL59 HEK-293T C186(0.88)  LDD1653  [9]
 LDCM0452  CL60 HEK-293T C186(0.87); C165(1.86)  LDD1655  [9]
 LDCM0453  CL61 HEK-293T C186(1.08); C165(0.89)  LDD1656  [9]
 LDCM0454  CL62 HEK-293T C186(0.98)  LDD1657  [9]
 LDCM0455  CL63 HEK-293T C186(0.94)  LDD1658  [9]
 LDCM0456  CL64 HEK-293T C186(0.93)  LDD1659  [9]
 LDCM0457  CL65 HEK-293T C186(0.97); C165(1.17)  LDD1660  [9]
 LDCM0459  CL67 HEK-293T C186(0.97)  LDD1662  [9]
 LDCM0460  CL68 HEK-293T C186(0.97); C165(0.82)  LDD1663  [9]
 LDCM0461  CL69 HEK-293T C186(0.93); C165(1.26)  LDD1664  [9]
 LDCM0462  CL7 HEK-293T C186(0.88)  LDD1665  [9]
 LDCM0463  CL70 HEK-293T C186(1.00)  LDD1666  [9]
 LDCM0464  CL71 HEK-293T C186(0.95)  LDD1667  [9]
 LDCM0465  CL72 HEK-293T C186(0.91); C165(1.54)  LDD1668  [9]
 LDCM0466  CL73 HEK-293T C186(0.97); C165(1.34)  LDD1669  [9]
 LDCM0467  CL74 HEK-293T C186(1.04)  LDD1670  [9]
 LDCM0469  CL76 HEK-293T C186(1.03)  LDD1672  [9]
 LDCM0470  CL77 HEK-293T C186(0.96); C165(1.48)  LDD1673  [9]
 LDCM0472  CL79 HEK-293T C186(0.95)  LDD1675  [9]
 LDCM0473  CL8 HEK-293T C186(2.24); C165(1.45)  LDD1676  [9]
 LDCM0474  CL80 HEK-293T C186(1.05); C165(0.79)  LDD1677  [9]
 LDCM0475  CL81 HEK-293T C186(0.92); C165(1.13)  LDD1678  [9]
 LDCM0476  CL82 HEK-293T C186(0.98)  LDD1679  [9]
 LDCM0477  CL83 HEK-293T C186(0.97)  LDD1680  [9]
 LDCM0478  CL84 HEK-293T C186(0.91); C165(1.98)  LDD1681  [9]
 LDCM0479  CL85 HEK-293T C186(1.12); C165(0.98)  LDD1682  [9]
 LDCM0480  CL86 HEK-293T C186(1.00)  LDD1683  [9]
 LDCM0481  CL87 HEK-293T C186(0.86)  LDD1684  [9]
 LDCM0482  CL88 HEK-293T C186(0.95)  LDD1685  [9]
 LDCM0483  CL89 HEK-293T C186(0.97); C165(0.93)  LDD1686  [9]
 LDCM0484  CL9 HEK-293T C186(0.88); C165(1.06)  LDD1687  [9]
 LDCM0486  CL91 HEK-293T C186(0.93)  LDD1689  [9]
 LDCM0487  CL92 HEK-293T C186(0.92); C165(0.95)  LDD1690  [9]
 LDCM0488  CL93 HEK-293T C186(0.87); C165(1.08)  LDD1691  [9]
 LDCM0489  CL94 HEK-293T C186(0.91)  LDD1692  [9]
 LDCM0490  CL95 HEK-293T C186(1.09)  LDD1693  [9]
 LDCM0491  CL96 HEK-293T C186(0.90); C165(2.26)  LDD1694  [9]
 LDCM0492  CL97 HEK-293T C186(1.16); C165(1.41)  LDD1695  [9]
 LDCM0493  CL98 HEK-293T C186(0.99)  LDD1696  [9]
 LDCM0494  CL99 HEK-293T C186(0.92)  LDD1697  [9]
 LDCM0495  E2913 HEK-293T C186(0.87)  LDD1698  [9]
 LDCM0625  F8 Ramos C186(0.76)  LDD2187  [10]
 LDCM0572  Fragment10 Ramos C186(1.66)  LDD2189  [10]
 LDCM0573  Fragment11 Ramos C165(3.62)  LDD2190  [10]
 LDCM0574  Fragment12 Ramos C186(2.72)  LDD2191  [10]
 LDCM0575  Fragment13 Ramos C186(0.76)  LDD2192  [10]
 LDCM0576  Fragment14 Ramos C186(0.40); C165(2.61)  LDD2193  [10]
 LDCM0579  Fragment20 Ramos C186(3.60)  LDD2194  [10]
 LDCM0580  Fragment21 Ramos C186(1.38)  LDD2195  [10]
 LDCM0582  Fragment23 Ramos C186(1.21)  LDD2196  [10]
 LDCM0578  Fragment27 Ramos C186(0.91)  LDD2197  [10]
 LDCM0586  Fragment28 Ramos C186(0.65); C165(5.51)  LDD2198  [10]
 LDCM0588  Fragment30 Ramos C186(0.99)  LDD2199  [10]
 LDCM0589  Fragment31 Ramos C186(1.29)  LDD2200  [10]
 LDCM0590  Fragment32 Ramos C186(1.59)  LDD2201  [10]
 LDCM0468  Fragment33 HEK-293T C186(0.95)  LDD1671  [9]
 LDCM0596  Fragment38 Ramos C186(1.08)  LDD2203  [10]
 LDCM0566  Fragment4 Ramos C186(1.46)  LDD2184  [10]
 LDCM0427  Fragment51 HEK-293T C186(1.03)  LDD1631  [9]
 LDCM0610  Fragment52 Ramos C186(0.97)  LDD2204  [10]
 LDCM0614  Fragment56 Ramos C186(0.96)  LDD2205  [10]
 LDCM0569  Fragment7 Ramos C186(1.39)  LDD2186  [10]
 LDCM0571  Fragment9 Ramos C186(4.95)  LDD2188  [10]
 LDCM0022  KB02 HEK-293T C186(1.03); C165(0.55)  LDD1492  [9]
 LDCM0023  KB03 HEK-293T C186(0.94); C165(0.80)  LDD1497  [9]
 LDCM0024  KB05 OCI-AML-2 C198(3.61)  LDD3370  [3]
 LDCM0627  NUDT7-COV-1 HEK-293T C165(0.59)  LDD2206  [11]
 LDCM0628  OTUB2-COV-1 HEK-293T C165(0.38)  LDD2207  [11]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Pleckstrin homology domain-containing family F member 1 (PLEKHF1) . Q96S99
Syntenin-1 (SDCBP) . O00560
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ELL-associated factor 1 (EAF1) EAF family Q96JC9
Mediator of RNA polymerase II transcription subunit 4 (MED4) Mediator complex subunit 4 family Q9NPJ6
TRAF-interacting protein with FHA domain-containing protein A (TIFA) TIFA family Q96CG3
E2F-associated phosphoprotein (EAPP) . Q56P03
INO80 complex subunit E (INO80E) . Q8NBZ0
Pleckstrin homology domain-containing family F member 2 (PLEKHF2) . Q9H8W4
Proline-rich protein 13 (PRR13) . Q9NZ81

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
6 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
10 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
11 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.