Details of the Target

General Information of Target

Target ID LDTP06808
Target Name Vacuolar ATPase assembly integral membrane protein VMA21 (VMA21)
Gene Name VMA21
Gene ID 203547
Synonyms
MEAX; XMEA; Vacuolar ATPase assembly integral membrane protein VMA21; Myopathy with excessive autophagy protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MERPDKAALNALQPPEFRNESSLASTLKTLLFFTALMITVPIGLYFTTKSYIFEGALGMS
NRDSYFYAAIVAVVAVHVVLALFVYVAWNEGSRQWREGKQD
Target Bioclass
Other
Family
VMA21 family
Subcellular location
Endoplasmic reticulum membrane
Function Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum. {|HAMAP-Rule:MF_03058}.
Uniprot ID
Q3ZAQ7
Ensemble ID
ENST00000330374.7
HGNC ID
HGNC:22082

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HEC1B SNV: p.A7V .

Probe(s) Labeling This Target

PAL-AfBPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C055
 Probe Info  		16.11  LDD1752  [1]
C056
 Probe Info  		24.59  LDD1753  [1]
C091
 Probe Info  		10.27  LDD1782  [1]
C094
 Probe Info  		27.67  LDD1785  [1]
C159
 Probe Info  		7.67  LDD1839  [1]
C161
 Probe Info  		10.63  LDD1841  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Phosphatidylserine lipase ABHD16A (ABHD16A) ABHD16 family O95870
Diacylglycerol lipase-alpha (DAGLA) Lipase family Q9Y4D2
CDP-diacylglycerol--inositol 3-phosphatidyltransferase (CDIPT) CDP-alcohol phosphatidyltransferase class-I family O14735
Stearoyl-CoA desaturase (SCD) Fatty acid desaturase type 1 family O00767
Heme oxygenase 2 (HMOX2) Heme oxygenase family P30519
Very-long-chain enoyl-CoA reductase (TECR) Steroid 5-alpha reductase family Q9NZ01
V-type proton ATPase 21 kDa proteolipid subunit c'' (ATP6V0B) V-ATPase proteolipid subunit family Q99437
Transporter and channel
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Insulin-induced gene 2 protein (INSIG2) INSIG family Q9Y5U4
LHFPL tetraspan subfamily member 5 protein (LHFPL5) LHFP family Q8TAF8
Aquaporin-6 (AQP6) MIP/aquaporin (TC 1.A.8) family Q13520
Mitochondrial outer membrane protein SLC25A46 (SLC25A46) Mitochondrial carrier (TC 2.A.29) family Q96AG3
NIPA-like protein 3 (NIPAL3) NIPA family Q6P499
Vesicle-associated membrane protein 2 (VAMP2) Synaptobrevin family P63027
Solute carrier family 35 member E4 (SLC35E4) TPT transporter family Q6ICL7
Protein YIPF1 (YIPF1) YIP1 family Q9Y548
Transmembrane protein 60 (TMEM60) . Q9H2L4
Other
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ADP-ribosylation factor-like protein 6-interacting protein 1 (ARL6IP1) ARL6ip family Q15041
Plasmolipin (PLLP) MAL family Q9Y342
Ninjurin-2 (NINJ2) Ninjurin family Q9NZG7
ORM1-like protein 1 (ORMDL1) ORM family Q9P0S3
Vesicle transport protein SEC20 (BNIP1) SEC20 family Q12981
Receptor-transporting protein 2 (RTP2) TMEM7 family Q5QGT7
Protein YIF1A (YIF1A) YIF1 family O95070
Thrombospondin type-1 domain-containing protein 7A (THSD7A) . Q9UPZ6
Transmembrane protein 107 (TMEM107) . Q6UX40

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587