Details of the Target

General Information of Target

Target ID LDTP13034
Target Name Prostaglandin F2 receptor negative regulator (PTGFRN)
Gene Name PTGFRN
Gene ID 5738
Synonyms
CD9P1; EWIF; FPRP; KIAA1436; Prostaglandin F2 receptor negative regulator; CD9 partner 1; CD9P-1; Glu-Trp-Ile EWI motif-containing protein F; EWI-F; Prostaglandin F2-alpha receptor regulatory protein; Prostaglandin F2-alpha receptor-associated protein; CD antigen CD315
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAELQQLQEFEIPTGREALRGNHSALLRVADYCEDNYVQATDKRKALEETMAFTTQALAS
VAYQVGNLAGHTLRMLDLQGAALRQVEARVSTLGQMVNMHMEKVARREIGTLATVQRLPP
GQKVIAPENLPPLTPYCRRPLNFGCLDDIGHGIKDLSTQLSRTGTLSRKSIKAPATPASA
TLGRPPRIPEPVHLPVVPDGRLSAASSAFSLASAGSAEGVGGAPTPKGQAAPPAPPLPSS
LDPPPPPAAVEVFQRPPTLEELSPPPPDEELPLPLDLPPPPPLDGDELGLPPPPPGFGPD
EPSWVPASYLEKVVTLYPYTSQKDNELSFSEGTVICVTRRYSDGWCEGVSSEGTGFFPGN
YVEPSC
Target Bioclass
Immunoglobulin
Subcellular location
Endoplasmic reticulum membrane
Function
Inhibits the binding of prostaglandin F2-alpha (PGF2-alpha) to its specific FP receptor, by decreasing the receptor number rather than the affinity constant. Functional coupling with the prostaglandin F2-alpha receptor seems to occur. In myoblasts, associates with tetraspanins CD9 and CD81 to prevent myotube fusion during muscle regeneration.
Uniprot ID
Q9P2B2
Ensemble ID
ENST00000393203.3
HGNC ID
HGNC:9601

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
HDSF-alk
 Probe Info  		1.85  LDD0197  [1]
FBPP2
 Probe Info  		19.41  LDD0318  [2]
OPA-S-S-alkyne
 Probe Info  		K492(0.47); K522(2.13); K579(2.67); K576(2.67)  LDD3494  [3]
DBIA
 Probe Info  		C429(2.42)  LDD3314  [4]
5E-2FA
 Probe Info  		H206(0.00); H146(0.00)  LDD2235  [5]
m-APA
 Probe Info  		H206(0.00); H146(0.00)  LDD2231  [5]
IA-alkyne
 Probe Info  		C169(0.00); C655(0.00); C429(0.00)  LDD0165  [6]
Acrolein
 Probe Info  		H350(0.00); H116(0.00)  LDD0217  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C299(0.92)  LDD1507  [8]
 LDCM0237  AC12 HEK-293T C299(1.00)  LDD1510  [8]
 LDCM0259  AC14 HEK-293T C299(1.00); C119(0.58)  LDD1512  [8]
 LDCM0276  AC17 HEK-293T C299(1.04)  LDD1515  [8]
 LDCM0280  AC20 HEK-293T C299(0.97)  LDD1519  [8]
 LDCM0281  AC21 HEK-293T C299(0.99)  LDD1520  [8]
 LDCM0282  AC22 HEK-293T C299(0.80); C119(0.73)  LDD1521  [8]
 LDCM0285  AC25 HEK-293T C299(1.05)  LDD1524  [8]
 LDCM0288  AC28 HEK-293T C299(0.88)  LDD1527  [8]
 LDCM0289  AC29 HEK-293T C299(1.07)  LDD1528  [8]
 LDCM0291  AC30 HEK-293T C299(0.73); C119(0.90)  LDD1530  [8]
 LDCM0294  AC33 HEK-293T C299(1.23)  LDD1533  [8]
 LDCM0297  AC36 HEK-293T C299(1.02)  LDD1536  [8]
 LDCM0298  AC37 HEK-293T C299(0.90)  LDD1537  [8]
 LDCM0299  AC38 HEK-293T C299(0.82); C119(0.68)  LDD1538  [8]
 LDCM0301  AC4 HEK-293T C299(0.92)  LDD1540  [8]
 LDCM0303  AC41 HEK-293T C299(0.80)  LDD1542  [8]
 LDCM0306  AC44 HEK-293T C299(1.01)  LDD1545  [8]
 LDCM0307  AC45 HEK-293T C299(1.07)  LDD1546  [8]
 LDCM0308  AC46 HEK-293T C299(0.94); C119(0.91)  LDD1547  [8]
 LDCM0311  AC49 HEK-293T C299(0.94)  LDD1550  [8]
 LDCM0312  AC5 HEK-293T C299(0.93)  LDD1551  [8]
 LDCM0315  AC52 HEK-293T C299(0.92)  LDD1554  [8]
 LDCM0316  AC53 HEK-293T C299(1.02)  LDD1555  [8]
 LDCM0317  AC54 HEK-293T C299(0.97); C119(0.65)  LDD1556  [8]
 LDCM0320  AC57 HEK-293T C299(1.08)  LDD1559  [8]
 LDCM0323  AC6 HEK-293T C299(0.90); C119(0.87)  LDD1562  [8]
 LDCM0324  AC60 HEK-293T C299(0.91)  LDD1563  [8]
 LDCM0325  AC61 HEK-293T C299(0.89)  LDD1564  [8]
 LDCM0326  AC62 HEK-293T C299(0.85); C119(0.65)  LDD1565  [8]
 LDCM0248  AKOS034007472 HEK-293T C299(1.05)  LDD1511  [8]
 LDCM0356  AKOS034007680 HEK-293T C299(0.93)  LDD1570  [8]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [7]
 LDCM0368  CL10 HEK-293T C299(0.96); C119(0.70)  LDD1572  [8]
 LDCM0404  CL17 HEK-293T C299(0.77)  LDD1608  [8]
 LDCM0408  CL20 HEK-293T C299(0.93)  LDD1612  [8]
 LDCM0409  CL21 HEK-293T C299(0.90)  LDD1613  [8]
 LDCM0410  CL22 HEK-293T C299(1.03); C119(0.75)  LDD1614  [8]
 LDCM0417  CL29 HEK-293T C299(0.98)  LDD1621  [8]
 LDCM0421  CL32 HEK-293T C299(1.07)  LDD1625  [8]
 LDCM0422  CL33 HEK-293T C299(1.10)  LDD1626  [8]
 LDCM0423  CL34 HEK-293T C299(0.95); C119(0.93)  LDD1627  [8]
 LDCM0431  CL41 HEK-293T C299(0.91)  LDD1635  [8]
 LDCM0434  CL44 HEK-293T C299(0.94)  LDD1638  [8]
 LDCM0435  CL45 HEK-293T C299(0.99)  LDD1639  [8]
 LDCM0436  CL46 HEK-293T C299(0.91); C119(0.71)  LDD1640  [8]
 LDCM0440  CL5 HEK-293T C299(1.01)  LDD1644  [8]
 LDCM0444  CL53 HEK-293T C299(0.95)  LDD1647  [8]
 LDCM0447  CL56 HEK-293T C299(1.08)  LDD1650  [8]
 LDCM0448  CL57 HEK-293T C299(1.18)  LDD1651  [8]
 LDCM0449  CL58 HEK-293T C299(0.89); C119(0.90)  LDD1652  [8]
 LDCM0457  CL65 HEK-293T C299(0.93)  LDD1660  [8]
 LDCM0460  CL68 HEK-293T C299(1.05)  LDD1663  [8]
 LDCM0461  CL69 HEK-293T C299(1.15)  LDD1664  [8]
 LDCM0463  CL70 HEK-293T C299(0.99); C119(0.83)  LDD1666  [8]
 LDCM0470  CL77 HEK-293T C299(1.00)  LDD1673  [8]
 LDCM0473  CL8 HEK-293T C299(0.99)  LDD1676  [8]
 LDCM0474  CL80 HEK-293T C299(0.96)  LDD1677  [8]
 LDCM0475  CL81 HEK-293T C299(1.36)  LDD1678  [8]
 LDCM0476  CL82 HEK-293T C299(0.87); C119(0.71)  LDD1679  [8]
 LDCM0483  CL89 HEK-293T C299(0.90)  LDD1686  [8]
 LDCM0484  CL9 HEK-293T C299(0.94)  LDD1687  [8]
 LDCM0487  CL92 HEK-293T C299(0.92)  LDD1690  [8]
 LDCM0488  CL93 HEK-293T C299(1.15)  LDD1691  [8]
 LDCM0489  CL94 HEK-293T C299(1.06); C119(0.69)  LDD1692  [8]
 LDCM0107  IAA HeLa H350(0.00); H116(0.00)  LDD0221  [7]
 LDCM0022  KB02 HEK-293T C429(1.05)  LDD1492  [8]
 LDCM0023  KB03 HEK-293T C429(0.92)  LDD1497  [8]
 LDCM0024  KB05 IGR37 C429(2.42)  LDD3314  [4]
 LDCM0109  NEM HeLa N.A.  LDD0223  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CD9 antigen (CD9) Tetraspanin (TM4SF) family P21926

References

1 Fatty Acyl Sulfonyl Fluoride as an Activity-Based Probe for Profiling Fatty Acid-Associated Proteins in Living Cells. Chembiochem. 2022 Feb 16;23(4):e202100628. doi: 10.1002/cbic.202100628. Epub 2021 Dec 30.
2 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
3 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402