Details of the Target

General Information of Target

Target ID LDTP07913
Target Name GPI inositol-deacylase (PGAP1)
Gene Name PGAP1
Gene ID 80055
Synonyms
GPI inositol-deacylase; EC 3.1.-.-; Post-GPI attachment to proteins factor 1; hPGAP1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFLHSVNLWNLAFYVFMVFLATLGLWDVFFGFEENKCSMSYMFEYPEYQKIELPKKLAKR
YPAYELYLYGEGSYAEEHKILPLTGIPVLFLPGNAGSYKQVRSIGSIALRKAEDIDFKYH
FDFFSVNFNEELVALYGGSLQKQTKFVHECIKTILKLYKGQEFAPKSVAIIGHSMGGLVA
RALLTLKNFKHDLINLLITQATPHVAPVMPLDRFITDFYTTVNNYWILNARHINLTTLSV
AGGFRDYQVRSGLTFLPKLSHHTSALSVVSSAVPKTWVSTDHLSIVWCKQLQLTTVRAFF
DLIDADTKQITQNSKKKLSVLYHHFIRHPSKHFEENPAIISDLTGTSMWVLVKVSKWTYV
AYNESEKIYFTFPLENHRKIYTHVYCQSTMLDTNSWIFACINSTSMCLQGVDLSWKAELL
PTIKYLTLRLQDYPSLSHLVVYVPSVRGSKFVVDCEFFKKEKRYIQLPVTHLFSFGLSSR
KVVLNTNGLYYNLELLNFGQIYQAFKINVVSKCSAVKEEITSIYRLHIPWSYEDSLTIAQ
APSSTEISLKLHIAQPENNTHVALFKMYTSSDCRYEVTVKTSFSQILGQVVRFHGGALPA
YVVSNILLAYRGQLYSLFSTGCCLEYATMLDKEAKPYKVDPFVIIIKFLLGYKWFKELWD
VLLLPELDAVILTCQSMCFPLISLILFLFGTCTAYWSGLLSSASVRLLSSLWLALKRPSE
LPKDIKMISPDLPFLTIVLIIVSWTTCGALAILLSYLYYVFKVVHLQASLTTFKNSQPVN
PKHSRRSEKKSNHHKDSSIHHLRLSANDAEDSLRMHSTVINLLTWIVLLSMPSLIYWLKN
LRYYFKLNPDPCKPLAFILIPTMAILGNTYTVSIKSSKLLKTTSQFPLPLAVGVIAFGSA
HLYRLPCFVFIPLLLHALCNFM
Target Bioclass
Enzyme
Family
GPI inositol-deacylase family
Subcellular location
Endoplasmic reticulum membrane
Function Involved in inositol deacylation of GPI-anchored proteins. GPI inositol deacylation may important for efficient transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi.
Uniprot ID
Q75T13
Ensemble ID
ENST00000354764.9
HGNC ID
HGNC:25712

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
G361 SNV: p.T280I .
MOLT4 SNV: p.P434S .
SW837 Insertion: p.N605KfsTer7 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
HDSF-alk
 Probe Info  		2.64  LDD0197  [1]
DBIA
 Probe Info  		C455(2.52)  LDD3393  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C455(1.18)  LDD1507  [3]
 LDCM0215  AC10 HEK-293T C455(1.22)  LDD1508  [3]
 LDCM0276  AC17 HEK-293T C455(0.91)  LDD1515  [3]
 LDCM0277  AC18 HEK-293T C455(1.03)  LDD1516  [3]
 LDCM0279  AC2 HEK-293T C455(0.95)  LDD1518  [3]
 LDCM0285  AC25 HEK-293T C455(1.33)  LDD1524  [3]
 LDCM0286  AC26 HEK-293T C455(0.87)  LDD1525  [3]
 LDCM0294  AC33 HEK-293T C455(1.16)  LDD1533  [3]
 LDCM0295  AC34 HEK-293T C455(1.28)  LDD1534  [3]
 LDCM0303  AC41 HEK-293T C455(1.06)  LDD1542  [3]
 LDCM0304  AC42 HEK-293T C455(2.48)  LDD1543  [3]
 LDCM0311  AC49 HEK-293T C455(0.99)  LDD1550  [3]
 LDCM0313  AC50 HEK-293T C455(1.05)  LDD1552  [3]
 LDCM0320  AC57 HEK-293T C455(0.91)  LDD1559  [3]
 LDCM0321  AC58 HEK-293T C455(0.90)  LDD1560  [3]
 LDCM0356  AKOS034007680 HEK-293T C455(0.98)  LDD1570  [3]
 LDCM0369  CL100 HEK-293T C455(1.11)  LDD1573  [3]
 LDCM0373  CL104 HEK-293T C455(1.07)  LDD1577  [3]
 LDCM0377  CL108 HEK-293T C455(0.99)  LDD1581  [3]
 LDCM0382  CL112 HEK-293T C455(0.96)  LDD1586  [3]
 LDCM0386  CL116 HEK-293T C455(0.99)  LDD1590  [3]
 LDCM0391  CL120 HEK-293T C455(1.25)  LDD1595  [3]
 LDCM0395  CL124 HEK-293T C455(1.12)  LDD1599  [3]
 LDCM0399  CL128 HEK-293T C455(1.02)  LDD1603  [3]
 LDCM0403  CL16 HEK-293T C455(1.02)  LDD1607  [3]
 LDCM0404  CL17 HEK-293T C455(1.99)  LDD1608  [3]
 LDCM0405  CL18 HEK-293T C455(1.69)  LDD1609  [3]
 LDCM0416  CL28 HEK-293T C455(1.33)  LDD1620  [3]
 LDCM0417  CL29 HEK-293T C455(1.18)  LDD1621  [3]
 LDCM0419  CL30 HEK-293T C455(1.00)  LDD1623  [3]
 LDCM0429  CL4 HEK-293T C455(1.32)  LDD1633  [3]
 LDCM0430  CL40 HEK-293T C455(1.35)  LDD1634  [3]
 LDCM0431  CL41 HEK-293T C455(1.25)  LDD1635  [3]
 LDCM0432  CL42 HEK-293T C455(0.96)  LDD1636  [3]
 LDCM0440  CL5 HEK-293T C455(1.29)  LDD1644  [3]
 LDCM0443  CL52 HEK-293T C455(1.15)  LDD1646  [3]
 LDCM0444  CL53 HEK-293T C455(1.68)  LDD1647  [3]
 LDCM0445  CL54 HEK-293T C455(0.77)  LDD1648  [3]
 LDCM0451  CL6 HEK-293T C455(1.18)  LDD1654  [3]
 LDCM0456  CL64 HEK-293T C455(0.92)  LDD1659  [3]
 LDCM0457  CL65 HEK-293T C455(1.47)  LDD1660  [3]
 LDCM0458  CL66 HEK-293T C455(0.82)  LDD1661  [3]
 LDCM0469  CL76 HEK-293T C455(0.89)  LDD1672  [3]
 LDCM0470  CL77 HEK-293T C455(1.50)  LDD1673  [3]
 LDCM0471  CL78 HEK-293T C455(1.00)  LDD1674  [3]
 LDCM0482  CL88 HEK-293T C455(1.53)  LDD1685  [3]
 LDCM0483  CL89 HEK-293T C455(0.90)  LDD1686  [3]
 LDCM0485  CL90 HEK-293T C455(1.20)  LDD1688  [3]
 LDCM0022  KB02 A673 C455(2.91)  LDD2261  [2]
 LDCM0023  KB03 A673 C455(4.62)  LDD2678  [2]
 LDCM0024  KB05 PaTu 8988t C455(2.52)  LDD3393  [2]

References

1 Fatty Acyl Sulfonyl Fluoride as an Activity-Based Probe for Profiling Fatty Acid-Associated Proteins in Living Cells. Chembiochem. 2022 Feb 16;23(4):e202100628. doi: 10.1002/cbic.202100628. Epub 2021 Dec 30.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402